Personnel Information

写真a

KIMURA Tsuyoshi


Job title

Associate Professor

Laboratory Address

2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo

Mail Address

The inquiry by e-mail is 《here

Research Areas, Keywords

Gene delivery, Tissue engineering, Nanotechnology, High-pressure, decellularized tissue

Graduating School 【 display / non-display

  • Kyoto Institute of Technology, Faculty of Textile Science and Technology, 1997, Graduated

Graduate School 【 display / non-display

  • Kyoto Institute of Technology, Graduate School, Division of Engineering and Design Science, Doctor's Course, 2003.03, Completed

Degree 【 display / non-display

  • ph.D, Kyoto Institute of Technology

Campus Career 【 display / non-display

  • 2013.04
    -
    2023.03
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Biofunctional Restoration, Material-based Medical Engineering, Associate Professor
  • 2013.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Functional Material, Associate Professor
  • 2013.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Material-Based Medical Engineering, Associate Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, -, -, Associate Professor

External Career 【 display / non-display

  • 2003.04
    -
    2004.09
    National Caridiovascular Research Institute, Department of Medical Engineering, Postdctral Fellow
  • 2004.10
    -
    2007.03
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Assistant Prof
  • 2007.04
    -
    2013.03
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Assistant Professor
  • 2008.06
    -
    2008.12
    Stanford University, Department of Material Science and Engineering,
  • 2013.04
    -
    Now
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Associate Professor

Academic Society Affiliations 【 display / non-display

  • Japan Society for Biomaterials

  • The Society of Life Support Engineering

Research Areas 【 display / non-display

  • Biomedical engineering

 

Research Theme 【 display / non-display

  • Study for relationship between macrophage polarization and biomaterial using a novel polarization evaluation method, 2022.04 - 2026.03

  • Development of a device for capturing lymphocytes selectively, 2016.04 - 2019.03

  • Oligonucleotide delivery using high-pressurized lipoplex, 2009 - Now

  • Gene delivery using high pressure compacted DNA, 2008 - Now

Published Papers & Misc 【 display / non-display

  1. Say sreypich, Mika Suzuki, Yoshihide Hashimoto, Tsuyoshi Kimura, Akio Kishida. Effect of multi arm-PEG-NHS (polyethylene glycol n-hydroxysuccinimide) branching on cell adhesion to modified decellularized bovine and porcine pericardium Journal of Materials chemistry B. 2024.12; (5): 1244-1256. ( DOI )

  2. Shota Toda, Yoshihide Hashimoto, Naoko Nakamura, Masahiro Yamada, Ryusuke Nakaoka, Wataru Nomura, Masaya Yamamoto, Tsuyoshi Kimura, Akio Kishida. Characteristics of macrophage aggregates prepared by rotation culture and their response to polymeric materials Journal of Artificial Organs. 2024.01;

  3. Kohei Yabuuchi, Toru Katsumata, Tsuyoshi Shimoboji, Yoshihide Hashimoto, Tsuyoshi Kimura, Kazunari Akiyoshi, Akio Kishida. Variable swelling behavior of and drug encapsulation in a maleimide-modified hyaluronic acid nanogel-based hydrogel Polymer Journal. 2024.01;

  4. Tsuyoshi Kimura, Hanako Maeda, Moeko Hagiwara, Yoshihide Hashimoto, Naoko Nakamura, Wataru Nomura, Tadao Tanabe, Mako Kobayashi, Masaya Yamamoto, Takahide Matsushima, Hiroshi Asahara, Akio Kishida. Evaluation of Proinflammatory Response to Polymeric Materials Using a Macrophage Cell Line Genetically Tagged with a Luminescent Peptide Advanced Biomedical Engineering. 2024; 13 43-51.

  5. Naoto Washihira, Mika Murakami, Miho Nakamura, Sho Fujii, Takahide Matsushima, Hiroshi Asahara, Akio Kishida, Tadao Tanabe, Tsuyoshi Kimura, Mako Kobayashi, Masaya Yamamoto. Application of a genetically engineered macrophage cell line for evaluating cellular effects of UV/US-treated poly(ethylene terephthalate) microplastics. Colloids Surf B Biointerfaces. 2023.12; 234 113735. ( PubMed, DOI )

  6. Suphatra Hiranphinyophat, Tomoki Hiraoka, Mako Kobayashi, Sho Fujii, Akio Kishida, Tadao Tanabe, Tsuyoshi Kimura, Masaya Yamamoto. Fabrication of Polypropylene Nanoplastics Via Thermal Oxidation Reaction for Human Cells Responsiveness Studies. Langmuir. 2023.11; 39 (44): 15563-15571. ( PubMed, DOI )

  7. Kohei Yabuuchi, Mika Suzuki, Chen Liang, Yoshihide Hashimoto, Tsuyoshi Kimura, Kazunari Akiyoshi, Akio Kishida. Preparation of Cholesterol-Modified Hyaluronic Acid Nanogel-Based Hydrogel and the Inflammatory Evaluation Using Macrophage-like Cells. Gels. 2023.10; 9 (11): ( PubMed, DOI )

  8. Kohei Yabuuchi, Mika Suzuki, Chen Liang, Yoshihide Hashimoto, Tsuyoshi Kimura, Kazunari Akiyoshi, Akio Kishida.. Preparation of Cholesterol-Modified Hyaluronic Acid Nanogel-Based Hydrogel and the Inflammatory Evaluation Using Macrophage-like Cells. Gels. 2023.10; 9 (866): ( DOI )

  9. Dongzhe Wang,Narintadeach Charoensombut,Kinyoshi Kawabata,Tsuyoshi Kimura,Akio Kishida,Takashi Ushida,Katsuko S. Furukawa. Effect of Pressure Conditions in Uterine Decellularization Using Hydrostatic Pressure on Structural Protein Preservation Bioengineering. 2023.07; 10 (7): ( DOI )

  10. Kosuke Sugawa, Arisa Suzuki, Jotaro Honda, Taiku Yabuki, Hironobu Tahara, Yutaro Hayakawa, Masato Furuya, Hiroki Ikake, Tsuyoshi Kimura, Yasuhiro Kosuge, Satoshi Kurumi, Kouichi Takase, Joe Otsuki. Photothermal Therapeutic Ability of Copper Open-Shell Nanostructures that are Effective in Second Biological Transparency Window Based on Symmetry Breakinginduced Plasmonic Properties Journal of Materials Chemistry B. 2023.06; ( DOI )

  11. Ikuna Kanehara, Hiromasa Yamashita, Sho Fujii, Tsuyoshi Kimura, Masaya Yamamoto and Tadao Tanabe. Nano-sized polyethylene particles produced by nano-second UV laser ablation Lasers in Manufacturing and Materials Processing. 2023.06; ( DOI )

  12. Watcharaphol Tiskratok, Masahiro Yamada, Jun Watanabe, Qu Pengyu, Tsuyoshi Kimura, Hiroshi Egusa. Mechanoregulation of Osteoclastogenesis-inducing Potentials of Fibrosarcoma Cell Line by Substrate Stiffness International Journal of Molecular Sciences. 2023.05; 24 (10): 8959. ( DOI )

  13. Mika Suzuki, Tsuyoshi Kimura, Yuta Nakano, Mako Kobayashi, Masahiro Okada, Takuya Matsumoto, Naoko Nakamura, Yoshihide Hashimoto, Akio Kishida. Preparation of mineralized pericardium by alternative soaking for soft-hard interregional tissue application. J Biomed Mater Res A. 2023.02; 111 (2): 198-208. ( PubMed, DOI )

  14. Watcharaphol Tiskratok, Masahiro Yamada, Jun Watanabe, Nadia Kartikasari, Tsuyoshi Kimura, Hiroshi Egusa. Substrate stiffness controls proinflammatory responses in human gingival fibroblasts. Scientific Reports. 2023.01; 13 (1): 1358. ( PubMed, DOI )

  15. Wen-Jin Ho, Mako Kobayashi, Kozue Murata, Yoshihide Hashimoto, Kenji Izumi, Tsuyoshi Kimura, Hideo Kanemitsu, Kazuhiro Yamazaki, Tadashi Ikeda, Kenji Minatoya, Akio Kishida, Hidetoshi Masumoto. A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture. Scientific Reports. 2022.12; 12 (1): 22294. ( PubMed, DOI )

  16. Anri Koyanagi, Iichiroh Onishi, Karin Muraoka, Ikue Sato, Shingo Sato, Tsuyoshi Kimura, Akio Kishida, Kouhei Yamamoto, Masanobu Kitagawa, Morito Kurata. Identification of the Factor That Leads Human Mesenchymal Stem Cell Lines into Decellularized Bone. Bioengineering (Basel). 2022.09; 9 (10): ( PubMed, DOI )

  17. Mako Kobayashi, Naoki Ishida, Yoshihide Hashimoto, Jun Negishi, Hideki Saga, Yoshihiro Sasaki, Kazunari Akiyoshi, Tsuyoshi Kimura, Akio Kishida. Extraction and biological evaluation of atrix-bound nanovesicles (MBVs) from high-hydrostatic pressure-decellularized tissues. Int J Mol Sci. 2022.08; 23 (16): ( PubMed, DOI )

  18. Yutaro Hayakawa, Masato Furuya, Hironobu Tahara, Yasuhiro Kosuge, Tsuyoshi Kimura, Kosuke Sugawa, Joe Otsuki. Modulation technique of localized surface plasmon resonance of palladium nanospheres by coating with titanium dioxide shell for application to photothermal therapy agent Nanoscale Research Letters. 2022.06; 17 60. ( DOI )

  19. Masahiro Yamada, Tsuyoshi Kimura, Naoko Nakamura, Jun Watanabe, Ndia Kartikasari, Xindie He, Watcharaphol Tiskratok, Hayato Yoshioka, Hidenori Shinno, Hiroshi Egusa. The titanium nanosurface with biomimetic physical microenvironment to induce endogenous regeneration of the periodontium ACS Applied Materials & Interfaces. 2022.06; 14 (24): 27703-27719. ( DOI )

  20. Mika Suzuki, Tsuyoshi Kimura, Yukina Yoshida, Mako Kobayashi, Yoshihide Hashimoto, Hironobu Takahashi, Tatsuya Shimizu, Shota Anzai, Naoko Nakamura, Akio Kishida. In Vitro Tissue Reconstruction Using Decellularized Pericardium Cultured with Cells for Ligament Regeneration Polymers. 2022.06; 14 (12): 2351. ( DOI )

  21. Mika Suzuki, Tsuyoshi Kimura, Yukina Yoshida, Mako Kobayashi, Yoshihide Hashimoto, Hironobu Takahashi, Tatsuya Shimizu, Shota Anzai, Naoko Nakamura, Akio Kishida. In vitro tissue reconstruction using decellularized pericardium cultured with cells for ligament regeneration Polymers. 2022.06; 14 (12): 2351. ( DOI )

  22. Yoshihide Hashimoto, Akitatsu Yamashita, Jun Negishi, Tsuyoshi Kimura, Seiichi Funamoto, and Akio Kishida. 4-Arm PEG-Functionalized Decellularized Pericardium for Effective Prevention of Postoperative Adhesion in Cardiac Surgery ACS Biomaterials Science & Engineering . 2022.01; 8 (1): 261-272. ( DOI )

  23. Hiroki Tsutsumi, Ryota Kurimoto, Ryo Nakamichi, Tomoki Chiba, Takahide Matsushima, Yuta Fujii, Risa Sanada, Tomomi Kato, Kana Shishido, Yuriko Sakamaki, Tsuyoshi Kimura, Akio Kishida, Hiroshi Asahara. Generation of a tendon-like tissue from human iPS cells. J Tissue Eng. 2022.01; 13 20417314221074018. ( PubMed, DOI )

  24. Narintadeach Charoensombut, Kinyoshi Kawabata, Jeonghyun Kim, Minki Chang, Tsuyoshi Kimura, Akio Kishida, Takashi Ushida, Katsuko S Furukawa. Internal radial perfusion bioreactor promotes decellularization and recellularization of rat uterine tissue Journal of Bioscience and Bioengineering. 2022.01; 133 (1): 83-88. ( DOI )

  25. Tsuyoshi Kimura, Rino Tokunaga, Yoshihide Hashimoto, Naoko Nakamura, Akio Kishida. Tumor growth suppression by implantation of an anti-CD25 antibody-immobilized material near the tumor via regulatory T cell capture Science and Technology of Advanced Materials. 2021.06; 22 (1): 607-615.

  26. Mako Kobayashi,Masako Ohara,Yoshihide Hashimoto,Naoko Nakamura,Toshiya Fujisato,Tsuyoshi Kimura,Akio Kishida. Effect of luminal surface structure of decellularized aorta on thrombus formation and cell behavior PLOS ONE. 2021.05; ( DOI )

  27. Mako Kobayashi,Masao Ohara,Yoshihide Hashimoto,Naoko Nakamura,Toshiya Fujisato,Tsuyoshi Kimura,Akio Kishida. In vitro evaluation of surface biological properties of decellulaized cardiovasucular use J Mater.Chem.B. 2020.12; 2020 (48): 10977-10989. ( DOI )

  28. Masaki Watanabe,Hanao Maedam,Yoshihide Hashimoto,Tsuyorhi Kimura,Akio Kishida. protein adsorption and cell adhension behavior of engineering plastics plasticized by supercritical carbon dioxide Dental Materials Journal. 2020.12; 39 (6): 1033-1038. ( DOI )

  29. Naoko Nakamura,Kazuki Saito,Tsuyoshi Kimura,Akio Kishida. Recellularization of decellularized cancellous bone scaffolds using lowtemperature cell seeding Tissue and Cell. 2020.10; 66 ( DOI )

  30. Yongwei Zhang,Kwangwoo Nam,Tsuyoshi Kimura,Pingli Wu,Naoko Nakamura,Yoshihide Hashimoto,Seiichi Funamoto,Akio Kishida. Preparation of gradient-type biological tissue–polymer complex for interlinking device Mater. Sci. Eng. C-Mater. Biol. Appl. . 2020.09; 114 ( DOI )

  31. Mako Kobayashi,Junpei Kadota,Yoshihide Hashimoto,Toshiya Fujisato,Naoko Nakamura,Tsuyoshi Kimura,Akio Kishida. Elastic Modulus of ECM Hydrogels Derived from Decellularized Tissue A ects Capillary Network Formation in Endothelial Cells International Journal of Molecular Sciences. 2020.09; 21 (17): ( DOI )

  32. Masaki Watanabe,Yoshihide Hashimoto,Tsuyoshi Kimura,Akio Kishida. Characterization of Engineering Plactis Plasticized Using Supercritical Co2 polymers. 2020.01; 12 (1): ( DOI )

  33. Nakamura Naoko, Harukaze Hiroki, Kato Yoki, Kimura Tsuyoshi, Kishida Akio. 歯周靱帯再構築を目指した脱細胞化靱帯および腱シートの調製(Preparation of decellularized ligament and tendon sheets for reconstruction of periodontal ligament) 人工臓器. 2019.10; 48 (2): S-140. ( ichushi )

  34. Kimura Tsuyoshi, Tokunaga Rino, Hashimoto Yoshihide, Nakamura Naoko, Kishida Akio. 癌治療への応用を目指した細胞移動に基づく移植可能な免疫調節材料の開発(Development of an implantable immunomodulatory material based on cell moving for cancer treatment) 人工臓器. 2019.10; 48 (2): S-144. ( ichushi )

  35. Yoshihide Hashimoto, Seiichi Funamoto, Shuji Sasaki, Jun Negishi, Shynya Hattori, Takako Honda, Tsuyoshi Kimura, Hisatoshi Kobayashi, Akio Kishida. Re-epithelialization and remodeling of decellularized corneal matrix in a rabbit corneal epithelial wound model Mater Sci Eng C-Mater Biol App. 2019.09; 102 238-246. ( DOI )

  36. Naoko Nakamura, Ai Ito, Tsuyoshi Kimura, Akio Kishida. Extracellular matrix induces periodontal ligament reconstruction in vivo International Journal of Molecular Sciences. 2019.07; 20 (13): 3277. ( DOI )

  37. N. Watanabe, M. Mizuno, J. Matsuda, N. Nakamura, K. Otabe, H. Katano, N. Ozeki, Y. Kohno, T. Kimura, K. Tsuji, H. Koga, A. Kishida, I. Sekiya. Comparison of high‐hydrostatic‐pressure decellularized versus freeze‐thawed porcine menisci J Orthop Res. 2019.06; 37 (11): 2466-2475. ( DOI )

  38. Kengo Iwasaki, Keiko Akazawa, Mizuki Nagata, Motohiro Komaki, Izumi Honda, Chikako Morioka, Naoki Yokoyama, Hirohito Ayame, Kazumasa Yamaki, Yuichi Tanaka, Tsuyoshi Kimura, Akio Kishida, Tetsuro Watabe, Ikuo Morita. The Fate of Transplanted Periodontal Ligament Stem Cells in Surgically Created Periodontal Defects in Rats International Journal of Molecular Sciences. 2019.01; 20 (1): ( DOI )

  39. Pingli Wu, Naoko Nakamura, Hiroko Morita, Kwangwoo Nam, Toshiya Fujisato, Tsuyoshi Kimura, Akio Kishida. A hybrid small‐diameter tube fabricated from decellularized aortic intima‐media and electrospun fiber for artificial small‐diameter blood vessel Journal of Biomedical Materials Research Part A. 2019; ( DOI )

  40. Tsuyoshi Kimura, Mayuka Kondo, Yoshihide Hashimoto, Toshiya Fujisato, Naoko Nakamura, Akio Kishida. Surface Topography of PDMS Replica Transferred from Various Decellularized Aortic Lumens Affects Cellular Orientation ACS Biomater Sci Eng. 2019; ( DOI )

  41. Yongwei Zhang, Takuya Iwata, Kwangwoo Nam, Tsuyoshi Kimura, Pingli Wu, Naoko Nakamura, Yoshihide Hashimoto, Akio Kishida. Water absorption by decellularized dermis Heliyon. 2018.04; 4 (4): 1-17. ( DOI )

  42. K. Akazawa, K. Iwasaki, M. Nagata, N. Yokoyama, H. Ayame, K. Yamaki, Y. Tanaka, I. Honda, C. Morioka, T. Kimura, M. Komaki, A. Kishida, Y. Izumi, I. Morita. Cell transfer technology for tissue engineering Inflammation and Regeneration. 2017.10; 37 (21): 1-6. ( DOI )

  43. Akazawa Keiko, Iwasaki Kengo, Nagata Mizuki, Yokoyama Naoki, Ayame Hirohito, Yamaki Kazumasa, Tanaka Yuichi, Honda Izumi, Morioka Chikako, Kimura Tsuyoshi, Komaki Motohiro, Kishida Akio, Izumi Yuichi, Morita Ikuo. 組織工学における細胞移植技術(Cell transfer technology for tissue engineering) Inflammation and Regeneration. 2017.10; 37 (October): 1-6. ( ichushi )

  44. Tsuyoshi Kimura, Naoko Nakamura, Kanji Umeda, Yoshihide Hashimoto, Akio Kishida. Capture and release of cells using a temperature-responsive surface that immobilizes an antibody through DNA duplex formation Journal of Biomaterials Science: Polymer Edition. 2017.03; 28 (10-12): 1172-1182. ( DOI )

  45. Jun Negishi, Yoshihide Hashimoto, Akitasu Yamashita, YoungWei Zhang, Tsuyoshi Kimura, Akio Kishida, Seiichi Funamoto. Evaluation of small-diameter vascular grafts reconstructed from decellularized aorta sheets Journal of Biomedical Materials Research Part A. 2017.01; 105 (5): 1293-1298. ( DOI )

  46. Jun Negishi, Yoshihide Hashimoto, Akitatsu Yamashita, Tsuyoshi Kimura, Akio Kishida, Seiichi Funamoto. Histological structure affects recellularization of decellularized arteries Materials Science and Engineering C. 2017.01; 70 450-455.

  47. Tsuyoshi Kimura*, Naoko Nakamura, Nao Sasaki, Yoshihide Hashimoto, Shimon Sakaguchi, Shunsaku Kimura, and Akio Kishida. Capture and release of target cells using a surface that immobilizes an antibody via desthiobiotin–avidin interaction Sensor and Materials. 2016.12; 28 (12): 1255-1263.

  48. Naoko Nakamura, Tsuyoshi Kimura, Akio Kishida. Overview of the Development, Applications, and Future Perspectives of Decellularized Tissues and Organs ACS Biomaterials Science and Engineering. 2016.11; 3 (7): 1236-1244. ( DOI )

  49. Keiko Akazawa, Kengo Iwasaki*, Mizuki Nagata, Naoki Yokoyama, Hirohito Ayame, Kazumasa Yamaki, Yuichi Tanaka, Izumi Honda, Chikako Morioka, Tsuyoshi Kimura, Motohiro Komaki, Akio Kishida, Yuichi Izumi, and Ikuo Morita. Double-layered cell transfer technology for bone regeneration Scientific Report. 2016.09; 6 33286.

  50. Yoshihide Hashimoto, Shinya Hattori, Shuji Sasaki, Takako Honda, Tsuyoshi Kimura, Seiichi Funamoto, Hisatoshi Kobayashi and Akio Kishida. Ultrastructural analysis of the decellularized cornea after interlamellar keratoplasty and microkeratome-assisted anterior lamellar keratoplasty in a rabbit model Scientific Reports. 2016.06; 6 27734.

  51. Y. Suwa, K. Nam, K. Ozeki, T. Kimura, A. Kishida, T. Masuzawa. Thermal denaturation behavior of collagen fibrils in wet and dry environment J Biomed Mater Res Part B: Appl Biomater. 2016.04; 104 (3): 538-545. ( DOI )

  52. Jun Negishi, Seiichi Funamoto,Tsuyoshi Kimura, Kwangwoo Nam, Tetsuya Higami, Akio Kishida. Porcine radial artery decellularization by high hydrostatic pressure. J Tissue Eng Regen Med. 2015.11; 9 E114-E151. ( PubMed, DOI )

  53. Pingli Wu, Naoko Nakamura, Tsuyoshi Kimura, Kwangwoo Nam, Toshiya Fujisato, Seiichi Funamoto, Tetsuya Higami, Akio Kishida. Decellularized porcine aortic intima-media as a potential cardiovascular biomaterial Interact Cardiovasc Thorac Surg. 2015.08; 21 (2): 189-194. ( DOI )

  54. Yoshihide Hashimoto, Seiichi Funamoto, Shuji Sasaki, Jun Negishi, Takako Honda, Shinya Hattori, Kwangwoo Nam, Tsuyoshi Kimura, Manabu Mochizuki, Hisatoshi Kobayashi, Akio Kishida. Corneal Regeneration by Deep Anterior Lamellar Keratoplasty (DALK) Using Decellularized Corneal Matrix PLOS ONE. 2015.07; 10 (7): e0131989. ( DOI )

  55. Aki Matsuhashi, Kwangwoo Nam, Tsuyoshi Kimura, Akio Kishida. Fabrication of fibrillized collagen microspheres with microstructure resembling extracellular matrix Soft Matter. 2015.04; 11 (14): 2844-2851. ( DOI )

  56. Aki Matsuhashi, Kwangwoo Nam, Tsuyoshi Kimura, Akio Kishida. Fundamental study on controlling preparative condisition of fibrillized collagen microsphere resembling the extracellular matrix mcrostructure Annual Reports of the Institute of Biomaterials and Bioengineering. 2014.12; 48 17-21.

  57. Kwangwoo Nam, Rie Matsushima, Tsuyoshi Kimura, Toshiya Fujisato, Akio Kishida. In vivo characterization of a decellularized dermis-polymer complex for use in percutaneous devices. Artif Organs. 2014.12; 38 (12): 1060-1065. ( PubMed, DOI )

  58. Kwangwoo Nam, Ji-Hun Seo, Tsuyoshi Kimura, Nobuhiko Yui, Akio Kishida. Relationships between molecular mobility, fibrillogenesis of collagen molecules, and the inflammatory response: An experimental study in vitro and in vivo Journal of Colloid and Interface Science . 2014.11; 433 16-25.

  59. Kwangwoo Nam, Yukiko shimatsu, Rie Matsushima, Tsuyoshi Kimura, Akio Kishida. In-situ polymerization of PMMA inside decellularized dermis using UV photopolymerization European Polymer Journal. 2014.11; 60 163-171.

  60. Jun Negishi, Kwangwoo Nam, Tsuyoshi Kimura, Yoshihide Hashimoto, Seiichi Funamoto, Tetsuya Higami, Toshiya Fujisato, Akio Kishida. Fabrication of a heparin-PVA complex hydrogel for application as a vascular access. J Biomed Mater Res B Appl Biomater. 2014.10; 102 (7): 1426-1433. ( PubMed, DOI )

  61. Tsuyoshi Kimura, Akira Okuno, Yuichi Ohya, Akio Kishida. Assembly of poly(vinyl alcohol) and DNA via Hydrogen Bonds Induced by High Hydrostatic Pressurization Sensors and Materials. 2014.10; 26 (8): 607-614.

  62. Kwangwoo Nam, Takuya Iwata, Tsuyoshi Kimura, Hiroki Ikake, Shigeru Shimizu, Toru Masuzawa, Akio Kishida. Adhesion Between Polymer Surface Modified by Graft Polymerization and Tissue During Surgery Using an Ultrasonically Activated Scalpel Device Journal of Applied Polymer Science . 2014.10; 131 (20): ( DOI )

  63. Ping Li Wu, Tsuyoshi Kimura, Hiroko Tadokoro, Kwangwoo Nam, Toshiya Fujisato, Akio Kishida. Relation between the tissue structure and protein permeability of decellularized porcine aorta. Mater Sci Eng C Mater Biol Appl. 2014.10; 43 465-471. ( PubMed, DOI )

  64. Jun Negishi, Yoshihide Hashimoto, Kwangwoo Nam, Tsuyoshi Kimura, Seiichi Funamoto, Akio Kishida. Application of a vacuum pressure impregnation technique for rehydrating decellularized tissues. Tissue Eng Part C Methods. 2014.09; 20 (9): 724-730. ( PubMed, DOI )

  65. Yuki Nagaoka, Hiroshi Yamada, Tsuyoshi Kimura, Akio Kishida, Toshiya Fujisato, Kazuo Takakuda. Reconstruction of small diameter arteries using decellularized vascular scaffolds. J Med Dent Sci. 2014.03; 61 (1): 33-40. ( PubMed )

  66. Rie Matsushima, Kwangwoo Nam, Yukiko Shimatsu, Tsuyoshi Kimura, Toshiya Fujisato, Akio Kishida. Decellularized dermis-polymer complex provides a platform for soft-to-hard tissue interfaces. Mater Sci Eng C Mater Biol Appl. 2014.02; 35 354-362. ( PubMed, DOI )

  67. Naoko Nakamura, Kiriko Sugano, Kwangwoo Nam, Tsuyoshi Kimura, Toshiya Fujisato, Akio Kishida. A Basic Study of Osteogenesis between Decellularized Cortical Bone Pieces for Bone Graft Construction Advanced Biomedical Engineering. 2014.01; 2 95-100.

  68. Tsuyoshi Kimura, Asami Sano, Kwangwoo Nam, Kazunari Akiyoshi, Yoshihiro Sasaki, Akio Kishida. Improvement of Antisense Oligonucleotides Delivery Using High Hydrostatic Pressurized Lipoplex Proceedings of 2012 MRS fall meeting MRS Proceedings. 2013.04; 1498 ( DOI )

  69. 12. Kwangwoo Nam*, Kenji Yamamoto, Kosuke Kasahara, Tsuyoshi Kimura, Seiicihi Funamoto, Shigeru Shimizu, Tetsuya Higami, Toru Masuzawa, Akio Kishida. Fundamental study on the development of a surgical device for polymer-tissue adhesion using vibration damping of polymeric materials Journal of Applied Polymer Science. 2013; 130 (4): 2532-2537.

  70. Tsuyoshi Kimura, Yukie Kanda, Kimio Kurita, Kwangwoo Nam, Akio Kishida. High hydrostatic pressurized lipoplex enhanced the transfection efficiency in vitro Advanced Biomedical Engineering. 2013; 2 80-83.

  71. Kwangwoo Nam, Yuuki Sakai, Yoshihide Hashimoto, Tsuyoshi Kimura, Akio Kishida. Fabrication of a heterostructural fibrillated collagen matrix for the regeneration of soft tissue function. Soft Matter. 2012; 8 472-480.

  72. Takahiro Kawashima, Yuhei Yamada, Yuuta Matsuzawa, Moeto Nagai, Takayuki Shibata, Toru Masuzawa, Tsuyoshi Kimura, Akio Kishida,. Development of Cell Culture Microdevice Integrated with Piezoelectric Thin Film Actuator for On-Chip Regulation of Cell Functions, Japanese Journal of Applied Physics. 2012; 51 10721.

  73. Negishi Jun, Funamoto Seiichi, Kimura Tsuyoshi, Nam Kwangoo, Higami Tetsuya, Kishida Akio. Effect of treatment temperature on collagen structures of the decellularized carotid artery using high hydrostatic pressure. J Artif Organs. 2011.09; 14 (3): 223-231. ( PubMed, DOI )

  74. Yamamoto Kenji, Kimura Tsuyoshi, Nam Kwangwoo, Funamoto Seiichi, Ito Yukiko, Shiba Kumiko, Katoh Ayako, Shimizu Shigeru, Kurita Kimio, Higami Tetsuya, Masuzawa Toru, Kishida Akio. Synthetic polymer-tissue adhesion using an ultrasonic scalpel. Surg Endosc. 2011.04; 25 (4): 1270-1275. ( PubMed, DOI )

  75. Yukiko Ito, Tsuyoshi Kimura, Kwangwoo Nam, Ayako Katoh, Toru Masuzawa, Akio Kishida. Effects of vibration on differentiation of cultured PC12 cells. Biotechnol Bioeng. 2011.03; 108 (3): 592-599. ( PubMed, DOI )

  76. Kwangwoo Nam, Yuuki Sakai, Seiichi Funamoto, Tsuyoshi Kimura, Akio Kishida, ,. Engineering a Collagen Matrix that Replicates the Biological Properties of Native Extracellular Matrix. Journal of Biomaterials Science-Polymer Edition. 2011;

  77. Shingo Mutsuo, Kazuya Yamamoto, Tsutomu Furuzono, Tsuyoshi Kimura, Tsutomu Ono, Akio Kishida. Release behavior from hydrogen-bonded polymer gels prepared by pressurization. Journal of Applied Polymer Science. 2011; 119 (5): 2725-2729.

  78. Kenji Yamamoto, Tsuyoshi Kimura, Kwangwoo Nam, Seiichi Funamoto, Yukiko Ito, Kumiko Shiba, Ayako Kato, Shigeru Shimizu, Kimio Kurita, Tetsuya Higami, Toru Masuzawa, Akio Kishida. Synthetic polymer-tissue adhesion using an ultrasonic scalpel. Surgical Endoscopy. 2011; 25 1270-1275.

  79. Yoshihide Hashimoto, Seiichi Funamoto, Tsuyoshi Kimura, Kwangwoo Nam, Toshiya Fujisato, Akio Kishida,. The effect of decellularized bone/bone marrow produced by high-hydrostatic pressurization on the osteogenic differentiation of mesenchymal stem cells. Biomaterials. 2011; 32 (29): 7060-7067. ( DOI )

  80. Tsuyoshi Kimura, Yoichi Nibe, Seiichi Funamoto, Masahiro Okada, Tsutomu Furuzono, Tsutomu Ono, Hidekazu Yoshizawa, Toshiya Fujisato, Kwangwoo Nam, Akio Kishida. Preparation of a nano-scaled poly (vinyl alcohol)/hydroxyapatite/DNA complex using high hydrostatic pressure technology and in vitro and in vivo gene delivery. Journal of Drug Delivery. 2011; 2011 ( DOI )

  81. Kwangwoo Nam, Yuusuke Tsutsumi, Chiaki Yoshikawa, Yuuko Tanaka, Rie Fukaya, Tsuyoshi Kimura, Hisatoshi Kobayashi, Takao Hanawa, Akio Kishida. Preparation of novel polymer-metal oxide nanocomposites with nanophase separated hierarchical structure. Bull. Mater. Sci.. 2011; 34 (7): 1289-1296. ( DOI )

  82. Yukiko Ito, Tsuyoshi Kimura, Yusuke Ago, Kwangwoo Nam, Kaori Hiraku, Kozo Miyazaki, Toru Masuzawa, Akio Kishida. Nano-vibration effect on cell adhesion and its shape. Bio-Medical Materials and Engineering. 2011; 21 (3): 149-158. ( DOI )

  83. Nam Kwangwoo, Sakai Yuuki, Funamoto Seiichi, Kimura Tsuyoshi, Kishida Akio. Engineering a collagen matrix that replicates the biological properties of native extracellular matrix. J Biomater Sci Polym Ed. 2011; 22 (15): 1963-1982. ( PubMed, DOI )

  84. Negishi Jun, Nam Kwangwoo, Kimura Tsuyoshi, Fujisato Toshiya, Kishida Akio. High-hydrostatic pressure technique is an effective method for the preparation of PVA-heparin hybrid gel. Eur J Pharm Sci. 2010.12; 41 (5): 617-622. ( PubMed, DOI )

  85. Oya Kei, Tanaka Yuta, Moriyama Yoshihisa, Yoshioka Yuki, Kimura Tsuyoshi, Tsutsumi Yusuke, Doi Hisashi, Nomura Naoyuki, Noda Kazuhiko, Kishida Akio, Hanawa Takao. Differences in the bone differentiation properties of MC3T3-E1 cells on polished bulk and sputter-deposited titanium specimens. J Biomed Mater Res A. 2010.08; 94 (2): 611-618. ( PubMed, DOI )

  86. Katoh Ayako, Masuzawa Toru, Ozeki Kazuhide, Kishida Akio, Kimura Tsuyoshi, Higami Tetsuya. Development of tissue adhesion method using integrated low-level energies. Med Eng Phys. 2010.05; 32 (4): 304-311. ( PubMed, DOI )

  87. Kwangwoo Nam, Tsuyoshi Kimura, Seiichi Funamoto, Akio Kishida. Preparation of a collagen/polymer hybrid gel designed for tissue membranes. Part I: controlling the polymer-collagen cross-linking process using an ethanol/water co-solvent. Acta Biomater. 2010.02; 6 (2): 403-408. ( PubMed, DOI )

  88. Nam Kwangwoo, Kimura Tsuyoshi, Funamoto Seiichi, Kishida Akio. Preparation of a collagen/polymer hybrid gel for tissue membranes. Part II: in vitro and in vivo biological properties of the collagen gels. Acta Biomater. 2010.02; 6 (2): 409-417. ( PubMed, DOI )

  89. Yoshihide Hashimoto, Seiichi Funamoto, Shuji Sasaki, Takako Honda, Shinya Hattori, Kwangwoo Nam, Tsuyoshi Kimura, Manabu Mochizuki, Toshiya Fujisato, Hisatoshi Kobayashi, Akio Kishida. Preparation and characterization of decellularized cornea using high-hydrostatic pressurization for corneal tissue engineering. Biomaterials. 2010; 31 (14): 3941-3948.

  90. Takahiro Kawashima, Tsuyoshi Kimura, Takayuki Shibata, Akio Kishida, Takashi Mineta, Eiji Makino. Feasibility study on cellular network analysis with patterned cell culture microdevice. Microelectronic Engineering. 2010; 87 (5-8): 704-707.

  91. Akio Kishida, Seiichi Funamoto, Jun Negishi, Yoshihide Hashimoto, Kwangwoo Nam, Tsuyoshi Kimura, Toshiya Fujisato, Hisatoshi Kobayashi. Tissue Engineering with Natural Tissue Matrices. Advances in Science and Technology,. 2010; 76 125-132.

  92. Kei Oya, Yuta Tanaka, Yoshihisa Moriyama, Yuki Yoshioka, Tsuyoshi Kimura, Yusuke Tsutsumi, Hisashi Doi, Naoyuki Nomura, Kazuhiko Noda, Akio Kishida, Takao Hanawa. Differences in the bone differentiation properties of MC3T3-E1 cells on polished bulk and sputter-deposited titanium specimens. Journal of Biomedical Materials Research Part A: Applied Biomaterials. 2010; 94A (2): 611-618.

  93. Kwangwoo Nam, Rie Fukaya, Yoshihide Hashimoto, Yukiko Ito, Tsuyoshi Kimura, Akio Kishida. Human Mesenchymal Stem Cell Behavior on Concentrated Polymer Burudhes Presenting Different Surface Stiffness. Chemistry Letters. 2010; 39 (11): 1164-1165.

  94. Jun Negishi, Kwangwoo Nam, Tsuyoshi Kimura, Toshiya Fujisato, Akio Kishida. High-hydrostatic pressure technique is an effective method for the preparation of PVA-heparin hybrid gel. European Journal of Pharmaceutical Sciences. 2010; 41 (5): 617-622.

  95. Ayako Katoh, Toru Masuzawa, Kazuhide Ozeki, Akio Kishida, Tsuyoshi Kimura, Tetsuya Higami. Development of tissue adhesion method using integrated low-level energies. Medical Engineering & Physics. 2010; 32 (4): 304-311.

  96. Seiichi Funamoto, Kwangwoo Nam, Tsuyoshi Kimura, Ayako Murakoshi, Yoshihide Hashimoto, Kazuo Niwaya, Soichiro Kitamura, Toshiya Fujisato, Akio Kishida. The use of high-hydrostatic pressure treatment to decellularize blood vessels. Biomaterials. 2010; 31 (13): 3590-3595.

  97. Shuji Sasaki, Seiichi Funamoto, Yoshihide Hashimoto, Tsuyoshi Kimura, Takako Honda, Shinya Hattori, Hisatoshi Kobayashi, Akio Kishida, Manabu Mochizuki. In vivo evaluation of a novel scaffold for artificial corneas prepared by using ultra-high hydrostatic pressure to decellularize porcine corneas. Molecular Vision. 2009; 15 2022-2028.

  98. Kimura Tsuyoshi, Konno Hokuto, Fujisato Toshiya, Kishida Akio. Expression behavior of high-pressure-compacted plasmid DNA in mammalian cell. Nucleic Acids Symp Ser (Oxf). 2009; (53): 313-314. ( PubMed, DOI )

  99. Nam Kwangwoo, Murakoshi Ayako, Kimura Tsuyoshi, Fujisato Toshiya, Kitamura Soichiro, Kishida Akio. Study on the physical properties of tissue-engineered blood vessels made by chemical cross-linking and polymer-tissue cross-linking. J Artif Organs. 2009; 12 (1): 47-54. ( PubMed, DOI )

  100. Nam Kwangwoo, Kimura Tsuyoshi, Kishida Akio. Controlling coupling reaction of EDC and NHS for preparation of collagen gels using ethanol/water co-solvents. Macromol Biosci. 2008.01; 8 (1): 32-37. ( PubMed, DOI )

  101. Shingo Mutsuo, Kazuya Yamamoto, Tsutomu Furuzono, Tsuyoshi Kimura, Tsutomu Ono, Akio Kihida. Pressure-induced molecular assembly of hydrogen-bonded polymers. Journal of Polymer Science: Part B: Polymer Physics,. 2008; 46 743-750.

  102. Kwangwoo Nam, Tsuyoshi Kimura, Akio Kishida. Controlling Coupling Reaction of EDC and NHS for Preparation of Collagen Gels Using Ethanol/Water Co-Solvents. Macromolecular Bioscience. 2008; 8 32-37.

  103. Nam Kwangwoo, Kimura Tsuyoshi, Kishida Akio. Physical and biological properties of collagen-phospholipid polymer hybrid gels. Biomaterials. 2007.07; 28 (20): 3153-3162. ( PubMed, DOI )

  104. Tsuyoshi Kimura, Seiichi Funamoto, Akio Kishida. Gene transfection on the tissue engineered bone decellularized by ultra high hydrostatic pressurization. Controlled Release Society Newsletter. 2007; 24 (2): 10-11.

  105. Kwangwoo Nam, Tsuyoshi Kimura, Akio Kishida. Preparation and cheracterization of cross-linked collagen-phospholid polymer hybrid gel. Biomaterials. 2007; 28 (1): 1-8.

  106. Kwangwoo Nam, Tsuyoshi Kimura, Akio Kishida. Physical and biological properties of collagen-phospholipid polymer hybrid gels. Biomaterials. 2007; 28 3153-3162.

  107. Kimura Tsuyoshi, Horiuchi Kana, Kurita Kimio, Ono Tsutomu, Yoshizawa Hidekazu, Fujisato Toshiya, Kishida Akio. Characteristics of compacted plasmid DNA by high pressurization. Nucleic Acids Symp Ser (Oxf). 2007; (51): 343-344. ( PubMed, DOI )

  108. Kimura Tsuyoshi, Iwai Sayaka, Moritan Toshiyuki, Nam Kwangwoo, Mutsuo Shingo, Yoshizawa Hidekazu, Okada Masahiro, Furuzono Tsutomu, Fujisato Tosihya, Kishida Akio. Preparation of poly(vinyl alcohol)/DNA hydrogels via hydrogen bonds formed on ultra-high pressurization and controlled release of DNA from the hydrogels for gene delivery. J Artif Organs. 2007; 10 (2): 104-108. ( PubMed, DOI )

  109. Okada Masahiro, Yasuda Shoji, Kimura Tsuyoshi, Iwasaki Mitsunobu, Ito Seishiro, Kishida Akio, Furuzono Tsutomu. Optimization of amino group density on surfaces of titanium dioxide nanoparticles covalently bonded to a silicone substrate for antibacterial and cell adhesion activities. J Biomed Mater Res A. 2006.01; 76 (1): 95-101. ( PubMed, DOI )

  110. Kwangwoo Nam, Tsuyoshi Kimura, Akio Kishida. Influence of cross-linking on physochemical and biological properties of collagen-phospholipid hybrid gel. Trans. Mater. Res. Soc. Jpn.. 2006; 31 (2): 735-738.

  111. Masahiro Okada, Syoji Yasuda, Tsuyoshi Kimrua, Mitsunobu Iwasaki, Seishiro Ito, Akio Kishida, Tsutomu Furuzono. Optimization of amino group density on surfaces of titanium dioxide nanoparticles covalently bonded to a silicone substrate for antibacterial and cell adhesion activities. Journal of Biomedical Materials Research Part A. 2006; 76A 95-101.

  112. Chiaki Yoshikawa, Atsushi Goto, Yoshinobu Tsujii, Takeshi Fukuda, Tsuyoshi Kimura, Kazuya Yamamoto, Akio Kishida. Protein Repellency of Well-Defined, Concentrated Poly(2-hydroxyethyl methacrylate) Brushes by the Size-Exclusion Effect. Macromolecules. 2006; 39 2284-2290.

  113. Tsuyoshi Kimura, Akira Okuno, Kozo Miyazaki, Tsutomu Furuzono, Yuichi Ohya, Tatsuro Ouchi, Shingo Mutsuo, Hidekazu Yoshizawa, Yoshiro Kitamura, Toshiya Fujisato, Akio Kishida,. Novel PVA-DNA nanoparticles prepared by ultra high pressure technology for gene delivery. Materials Science & Engineering C. 2004; 24 797-801.

  114. Furuzono Tsutomu, Yasuda Shoji, Kimura Tsuyoshi, Kyotani Singo, Tanaka Junzo, Kishida Akio. Nano-scaled hydroxyapatite/polymer composite IV. Fabrication and cell adhesion properties of a three-dimensional scaffold made of composite material with a silk fibroin substrate to develop a percutaneous device. J Artif Organs. 2004; 7 (3): 137-144. ( PubMed, DOI )

  115. Tsuyoshi Kimura, Tetsuji Yamaoka, Reiko Iwase, Akira Murakami. Effect of chemical features and stability of polyplexes on their gene transfer efficiency. Nucleic Acids Research Suppl.. 2002; (2): 107-108.

  116. Tsuyoshi Kimura, Tetsuji Yamaoka, Reiko Iwase, Akira Murakami. Effect of physicochemical properties of polyplexes composed of chemically modified PL derivatives on transfection efficiency in vitro. Macromolecular Bioscience. 2002; 2 437-446.

  117. Tsuyoshi Kimura, Tetsuji Yamaoka, Reiko Iwase, Akira Murakami. Structure/function relationship in the polyplexes containing cationic polypeptides for gene delivery. Nucleic Acids Research Suppl.. 2001; (1): 203-204.

  118. Yoshiyuki Koyama, Tomoko Ito, Tsuyoshi Kimura, Akira Murakami, Tetsuji Yamaoka. Effect of cholesteryl side chain and complexing with cholic acid on gene transfection by cationic poly(ethylene glycol) derivatives. Journal of Controlled Release. 2001; 77 357-364.

  119. Tsuyoshi Kimura, Tetsuji Yamaoka, Reiko Iwase, Akira Murakami. Effect of serine residue on the effectiveness of cationic polypeptide-based gene delivery. Nucleic Acids Symposium Series. 2000; 44 299-300.

  120. Tetsuji Yamaoka, Tsuyoshi Kimura, Reiko Iwase, Akira Murakami,. Enhanced expression of foreign gene transferred to mammalian cells in vitro using chemically modified Poly(L-lysine)s as gene carriers. Chemistry Letters. 2000; 118-119.

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Books etc 【 display / non-display

  1. Yoshihide Hashimoto, Seiichi Funamoto, Shuji Sasaki, Tsuyoshi Kimura, Hisatoshi Kobayashi, Akio Kishida. Decellularized matrix for corneal tissue engineering: Recent advances in development and clinical potential. RSC publishing, 2019.12 Chapter 12 (ISBN : 978-1-78801-467-0)

  2. Akio Kishida,Seiichi Funamoto,Jun Negishi,Yoshihide Hashmoto,Kwangoo Nam,Tsuyoshi Kimura,Toshiya Fujisato,Hisatoshi Kobayashi. Advances in Science and Technology. Trans Tech Publications, Switzerland, 2010.10 Tissue Engineering with Natural Tissue Matrics

  3. T. Kimura,S. Funamoto,A. Kishida. Controlled Release Society Newsletter. 2007.11 Gene transfection on the tissue engineered bone decellularized by ultra high hydrostatic pressurization

Conference Activities & Talks 【 display / non-display

  1. Mika Suzuki, Tsuyoshi Kimura, Varja cuculuvic, Ruri Ishigaki, Yoshihide Hashimoto, Takahide Matsushima, Hiroshi Asahara, Wataru Nomura, Kishida Akio. Evaluation of immunogenicity of various treated decellularized tissue using gene-modified THP-1. Materials Research Meeting (MRM) 2023 2023.12.16 Kyoto

  2. Masaya Yamamoto,Suphatra Hiranphinyophat,Tomoki Hiraoka,Naoto Washihira,Akio Kishida,Sho Fujii,Mako Kobayashi,Tadao Tanabe,Tsuyoshi Kimura. Fabrication of polypropylene nanoplastics via thermal oxidation reaction for human cells responsiveness studies. The 11th Pacific Rim International Conference on Advanced Materials and Processing 2023.11.19 Korea

  3. Tsuyoshi Kimura,Cehn Liang,Mika Suzuki,Yoshihide Hashimoto,Tadao Tanabe,Masaya Yamamoto,Akio Kishida. Evaluation of biological response to materials using intestinal epithelial cells and macrophages. The 11th Pacific Rim International Conference on Advanced Materials and Processing 2023.11.19 Korea

  4. Mako Kobayashi,Jun Negishi,Yoshihide Hashimoto,Masaya Yamamoto,Yoshihiro Sasaki,Kazunari Akiyoshi,Tsuyoshi Kimura,Akio Kishida. The 11th Pacific Rim International Conference on Advanced Materials and Processing. The 11th Pacific Rim International Conference on Advanced Materials and Processing 2023.11.19 Korea

  5. 鈴木美加,木村剛,岡田正弘,松本卓也,山田将博,江草宏, 中村奈緒子,岸田晶夫. 硬-軟境界組織応用を目指した石灰化dECM膜のin vivo骨親和性評価. バイオマテリアル学会 2023.11.06 神戸

  6. Akio Kishida, Hanako Maeda, Moeko Hagiwara, Yoshihide Hashimoto, Mako Kobayashi, Tsuyoshi Kimura. Pro-inflammatory characterization of biomaterials using genetically modified THP-1 cells. 33rd Annual Conference of European Society for Biomaterials 2023.09.04 Davos, Switzerland.

  7. Tsuyoshi KIMURA, Mika SUZUKI, Yoshihide HASHIMOTO, Masahiro OKADA, Takuya MATSUMOTO, Naoko NAKAMURA, Akio KISHIDA. Development of soft-hard internal tissue by mineralization of decellularized membrane. Biomaterials International 2023 2023.08.01

  8. M.Yamamoto, M. Murakami, N. Washihira, M. Nakamura, T. Matsushima, H. Asahara, A. Kishida,M. Kobayashi, S. Fujii, T. Tanabe, T. Kimura. Evaluation of cellular responses to oxidized poly(ethylene terephthalate) microplastics using a genetically engineered macrophage. Biomaterials International 2023 2023.07.30 Hokkaido, Japan

  9. T. Kimura, M.Suzuki, Y. Hashimoto, M. Okada, T. Matsumoto, N. Nakamura, Akio Kishida. Development of soft-hard interregional tissue by mineralization of decellularized membrane. Biomaterials International 2023 2023.07.30 Hokkaido, Japan

  10. Masaya Yamamoto,Tomoki Hiraoka,Suphatra Hiranphinyophat,Naoto,Washihira,Mako Kobayashi,Akio Kishida,Sho Fujii,Tadao Tanabe,Tsuyoshi Kimura. Fabrication of PP nanoparticles as nano- and microplastic models for cytotoxicity testing. The 13th SPSJ International Polymer Conference 2023.07.18 Hokkaido, Japan

  11. Sreypich SAY、Yoshihide HASHIMOTO、Tsuyoshi KIMURA、Akio KISHIDA. Fabrication and characterization of linear and branch PEGNHS to modify the porcine and bovine pericardium. 第72回高分子学会年次大会 2023.05.24 群馬県

  12. Tsuyoshi KIMURA, Mika SUZUKI, Yoshihide HASHIMOTO, Masahiro OKADA, Takuya MATSUMOTO, Naoko NAKAMURA, Akio KISHIDA. Development of soft-hard interregional tissue using a mineralized dECM membrane. Society For Biomaterials 2023 2023.04.19

  13. 木村剛、徳野陽子、内田健哉、萩原萌子、橋本良秀、岸田晶夫. 生体組織を模擬した 3D 配向コラーゲンナノファイバ構造体の皮膚フラップモデル評価. 第22回日本再生医療学会総会 2023.03.23 京都府

  14. Mako Kobayashi, Tsuyoshi Kimura, Akio Kishida, Masaya Yamamoto . he effect of decellularized tissue-derived hydrogels on cancer cell behavior. The 7th International Symposium on Biomedical Engineering (ISBE2022) 2022.11.25

  15. WenJin Ho, Hidetoshi Masumoto, Mako Kobayashi, Kozue Murata, Tadashi Ikeda, Yoshihide Hashimoto, Tsuyoshi Kimura, Kenji Minatoya, Akio Kishida. A novel approach for pre-implant endothelialization of xenogeneic decellularized vascular tissues by human endothelial cells utilizing tissue surface modification and dynamic culture. American Heart Association 2022 Scientific Sessions 2022.11.04

  16. Yoshihide Hashimoto, Takuya Akizawa, Moeko Hagiwara, Mako Kobayashi, Tsuyoshi Kimura, Akio Kishida. Cellular behaviors of human skeletal muscle satellite cells on tissue specific extracellular matrix coating and hydrogels. Visual-JW 2022 2022.10.25

  17. Mako Kobayashi、Naoki Ishida、Yoshihide Hashimoto、Jun Negishi、Hideki Saga、Takehiro Iwanaga、Yoshihiro Sasaki、Kazunari Akiyoshi、Tsuyoshi Kimura、Akio Kishida. The effects of matrix-bound nanovesicles(MBVs) derived from high-hydrostatic pressure decellularized tissued on neural regeneration. TERMIS-AP 2022 2022.10.05 South Korea

  18. Tsuyoshi Kimura、Mika Suzuki、Mako Kobayashi、Masahiro Okada、Takuya Matsumoto、Naoko Nakamura、Yoshihide Hashimoto、Akio Kishida. Development of a mineralized decellularized tissue for soft-hard inter-regional tissue application. TERMIS-AP 2022 2022.10.05 South Korea

  19. Mika Suzuki、Yuta Nakano、Yoshihide Hashimoto、Hironobu Takahashi、Tatsuya Shimizu、Noko Nakamura、Tsuyoshi Kimura、Akio Kishida. Recellularization of partially mineralized membranous decellularized tissue for locomotor regeneration. MRM2021 2021.12.13 神奈川

  20. Tsuyohi Kimura、Rino Tokunaga、Yoshihide Hashimoto、Naoko Nakamura、Akio Kishida. Tumor growth suppression by releasing cancer immune suppression using an anti-CD25 antibody-immobilized material. MRM2021 2021.12.13 神奈川

  21. Mika Suzuki, Yuta Nakano, Yoshihide Hashimoto, Hironobu Takahashi, Tatsuya Shimizu, Naoko Nakamura,Tsuyoshi Kimura, Akio Kishida . Preparation of a mineralized decellularized pericardium by alternate soaking for enhancing bone affinity. ISBE2021 2021.12.02 Web

  22. Tsuyoshi Kimura, Eri Yasuda, Yoshihide Hashimoto, Ikuro Suzuki, Naoko Nakamura, Akio Kishida. Classification of HHP and SDS decellularized tissue histology images using artificial intelligence. ISBE2021 2021.12.02 Web

  23. Yoshihide Hashimoto, Akitatsu Yamashita, Jun Negishi, Tsuyoshi Kimura, Seiichi Funamoto, Akio Kishida. Four-arm PEG-functionalized decellularized pericardium as an effective post-operative pericardial adhesion barrier. ISBE2021 2021.12.02 Web

  24. Tsuyoshi Kimura、Mika Suzuki、Yoshihide Hashimoto、Hironobu Takahashi、Tatsuya Shimizu、Naoko Nakamura、Akio Kishida. In vitro tissue reconstruction using decellularized pericardium cultured with cells for ligament regeneration. 2021 6th TERMIS-WC 2021.11.15 WEB開催

  25. Mako Kobayashi、Naoki Ishida、Yoshihide Hashimoto、Jun Negishi、Hideki Saga、Yoshihiro Sasaki、Kazunari Akiyoshi、Tsuyoshi Kimura、Akio Kishida. Extraction of matrix-bound nanovesicles (MBVs) from high-hydrostatic pressure decellularized tissue and evaluation on vascular endothelial cells. 2021 6th TERMIS-WC 2021.11.15 WEB開催

  26. Shota Toda、Yoshihide Hashimoto、Tsuyoshi Kimura、Akio Kishida. Preparation of macrophage adhering particles for immunological evaluation of biomaterials . 2021 6th TERMIS-WC 2021.11.15 WEB開催

  27. Tsuyoshi Kimura,Junpei Kadota,Naoko Nakamura,Yoshihide Hashimoto,Akio Kishida. Network formation of endothelial cells on decellularized ECM hydrogels. MRM2019 2019.12.10 Kanagawa,Japan

  28. A.kishida,J.kadota,N.nakamura,Y.hashimoto,T.kimura. Network formation of endothelial cells on hydrogels derived from decellurarized matrices. TERMIS-AM Annual Congress and Exhibition 2019.12.02 Orland,USA

  29. M.kobayashi,M,ohara,Y.hashimoto,N.nakamura,T.fujisato,T.kimura,A.kishida. Effect of basement membrane structure on cell behavior and function on decellularized aorta. TERMIS-AM Annual Congress and Exhibition 2019.12.02 Orland,USA

  30. Y. Yoshida, M. Suzuki, S. Anzai, N. Nakamura, T. Kimura, A. Kishida. Preparation of ligament-like tissue using decellularized pericardium. 2nd G'L'owing Polymer Symposium in KANTO 2019.11.30 Tokyo, Japan

  31. 中村奈緒子, 赤岩拓未, 石山雄大, 中根貴道, 木村剛, 岸田晶夫. がん治療を目指した流れの中における選択的細胞捕獲の検討. 第57回日本人工臓器学会大会 (JSAO2019) 2019.11.15 大阪

  32. Naoko Nakamura, Hiroki Harukaze, Yoki Kato, Tsuyoshi Kimura, Akio Kishida. Preparation of decellularized ligament and tendon sheets for reconstruction of periodontal ligament. International Federation for Artificial Organs (IFAO) 2019 2019.11.13 Osaka

  33. Tsuyoshi Kimura, Rino Tokunaga, Yoshihide Hashimoto, Naoko Nakamura, Akio Kishida. Development of an implantable immunomodulatory material basaed on cell moving for cancer treatment. International Federation for Artificial Organs (IFAO) 2019 2019.11.13

  34. Tsuyoshi Kimura, Rino Tokunaga, Yoshihide Hashimoto, Naoko Nakamura, Akio Kishida. Development of an immunomodulatory biomaterial for cancer. International Conference on Materials and Systems for Sustainability (ICMaSS) 2019.11.02 Nagoya

  35. T.Kimura,J.Kadota,N.Nakamura,Y.Hashimoto,A.Kishida. Network formation of endothelial cells on Hydrogels Deriverd from Decellularized Matrices. TERMIS-AP 2019 2019.10.14 AUSTRALIA

  36. Tsuvoshi Kimura,Yukina Yoshida,Shota Anzai,Hironobu Takahashi,Tatsuya Shimizu,Naoko Nakamura,Akio Kishida. Cell culture on various decellularized pericardiums. iLIM-4 2019.10.03 Miyagi,Japan

  37. Akio Kishida,Rino Tokunaga,Yoshihide Hashimoto,Naoko Nakamura,Tsuyoshi Kimura. Development of an antibody-immobilized filter for capturing target Cells. ESB2019 2019.09.09 Dresden,Germany

  38. Tsuyoshi Kimura、Mako Kobayashi、Yoshihide Hashimoto、Toshiya Fujisato、Naoko Nakamura、Akio Kishida. A synthetic replica having surface morphology of decellularized tissue regulated orientation and shape of cells. SFB2019 Annual Meeting and Exposition 2019.04.03 Seattle,USA

  39. Naoko Nakamura、Hiroki Harukaze、Ryota Ohira、Masahiro Yamada、Toshiya Fujisato、Tsuyoshi Kimura、Akio Kishida. Integration of decellularized ligament and artificial material through recellularization for periodontal reconstruction. SFB2019 Annual Meeting and Exposition 2019.04.03 Seattle,USA

  40. Mako Kobayashi、Mayuka Kondo、Ayano Tamura、Yoshihide Hashimoto、Toshiya Fujisat、Tsuyoshi Kimura、Akio Kishid. The effect of decellularization method on cell behavior on the decellularized aorta. SFB2019 Annual Meeting and Exposition 2019.04.03 Seattle,USA

  41. Junpei Kadota, Yoshihide Hashimoto, Toshiya Fujisato, Tsuyoshi Kimura, Akio Kishida. Characterization of ECM hydrogels prepared by different decellularization methods. 1st G’L’owing Polymer Symposium in KANTO 2018.12.15 Tokyo

  42. Mako Kobayashi, Mayuka Kondo, Ayano Tamura, Yoshihide Hashimoto,Toshiya Fujisato, Tsuyoshi Kimura, Akio Kishida. Cell behavior on the decellularized aorta with various basement membrane structures. 1st G’L’owing Polymer Symposium in KANTO 2018.12.15 Tokyo

  43. Tsuyoshi Kimura, Mayuka Kondo, Yoshihide Hashimoto, Toshiya Fujisato, Naoko Nakamura, Akio Kishida. Bio-surface replicated from decellularized tissue. 3rd International Sympodium on Creation of Life Innovation Materials for Interdiciplinary and International Researcher Development (iLIM-3) 2018.09.25 Tokyo

  44. Junpei Kadota, Yoshihide Hashimoto, Tsuyoshi Kimura, Akio Kishida. Preparation and characterization of ECM hydrogels derived from acellular urinary bladder matrix (UBM) and small intestinal submucosa (SIS). 3rd International Sympodium on Creation of Life Innovation Materials for Interdiciplinary and International Researcher Development (iLIM-3) 2018.09.25 Tokyo

  45. Tsuyoshi Kimura, Mayuka Kondo, Yoshihide Hashimoto, Toshiya Fujisato, Naoko Nakamura, Akio Kishida. Cellular behavior on decellularized tissue and its replica. Frontier 2018 2018.09.19 lausanne, Switzerland

  46. Junpei Kadota, Yoshihide Hashimoto, Tsuyoshi Kimura, Akio Kishida. In vitro microvascular network formation in/on hydrogels derived from decellularized tissues. Frontier 2018 2018.09.19 lausanne, Switzerland

  47. Tsuyoshi Kimura. Development of a synthetic replica having surface morphology of aortic lumen. Polymer minisympo in Tsukuba 2018.09.14

  48. Tsuyoshi Kimura, Mayuka Kondo, Yoshihide Hashimoto, Naoko Nakamura, Akio Kishida. Basement membrane topology of decellularized aorta and its synthetic replica affected endothelial cell behavior. 5Th TERMIS World Congress 2018.09.05 Kyoto

  49. Tsuyoshi Kimura, Mayuka Kondo, Yoshihide Hashimoto, Naoko Nakamura, Akio Kishida. Surface topology of decellularized aorta and its synthetic replica affected cell behavior. 5Th TERMIS World Congress 2018.09.04 Kyoto

  50. Naoko Nakamura, Shunya Shiba, Satoshi Shinohara, Shogo Suzuki, Tsuyoshi Kimura, Akio Kishida. An adipose tissue extraction method from decellularized cancerous bone for exploring hematopoietic-related extracellular matrix. 5Th TERMIS World Congress 2018.09.04 Kyoto

  51. Junpei Kadota, Yoshihide Hashimoto, Tsuyoshi Kimura, Akio Kishida. Preparation and characterization of hydrogels derived fromdecellularized urinary bladder matrix (UBM) and small intestinal submucosa (SIS). 5Th TERMIS World Congress 2018.09.04 Kyoto

  52. Naoko Nakamura, Tsuyoshi Kimura, Masahiro Okada, Toshiya Fujisato, Akio Kishida. Surface Modification of Artificial Tooth Root for Periodontal Tissue Reconstruction. 5Th TERMIS World Congress 2018.09.04 Kyoto

  53. Akio Kishida, Mayuka Kondo, Yoshihide Hashimoto, Toshiya Fujisato, Naoko Nakamura, Tsuyoshi Kimura.. Topological study of basement membrane of decellularized aorta using its synthetic replica. Finland-Japan Workshop: The next generation medical engineering in biomaterials 2018.06.17 Oulu, Finland

  54. Tsuyoshi Kimura, Naoko Nakamura, Shimon Sakaguchi, Shunsaku Kimura, Akio Kishida. Development of an antibody immobilizing device for label-free selective capture of target cells. Finland-Japan Workshop: The next generation medical engineering in biomaterials 2018.06.17 Oulu, Finland

  55. Tsuyoshi Kimura, Naoko Nakamra, Yoshihide Hashimoto, Akio Kishida. Induction of immunogenic cell death of cancer cell by using chemical detergent treatment and its activation of immune system. Experimental Biology 2018 2018.04.21 SanDiego, USA

  56. Tsuyoshi Kimura, Naoko Nakamura, Yoshihide Hashimoto, Akio Kishida. Development of an antibody immobilizing device for label-free selective capture and collection of stem cells. TERMIS-AM 2017 2017.12.03

  57. Masahiro Okada, Takuya Matsumoto, Akio Kishida, Tsuyoshi Kimura. Brush-like hydroxyapatite coating on biodegradable polymer substrate at low temperature. The 2nd international symposium on biomedical engineering 2017.11.09

  58. Ikuro Suzuki,Aoi Odawara,Naoko Nakamura,Akio Kishida,Tsuyoshi Kimura. Reconstruction of Brain Circuit on Decellularized Brain Tissue. 第2回生体医歯工学共同研究拠点国際シンポジウム 2017.11.09 東京都

  59. Naoko Nakamura,Tsuyoshi Kimura,Masahiro Yamada,Toshiya Fujisato,Takashi Tsuji,Akio Kishida. Periodontal Tissue Reconstruction Using Artificial Tooth and Decellularized PDL Matrix. 第2回生体医歯工学共同研究拠点国際シンポジウム 2017.11.09 東京都

  60. Hironobu Takahashi,Tsuyoshi Kimura,Akio kishida, Tatsuya Shimizu. 3D Construction of Anisotropic Cell Sheets Combined with Membranous Structures. 第2回生体医歯工学共同研究拠点国際シンポジウム 2017.11.09 東京都

  61. Naoko Nakamura, Tsuyoshi Kimura, Yoshihide Hashimoto, Shimon Sakaguchi, Shunsaku Kimura, Akio Kishida. Label-free Capture and Collection of Target Cells Using a Surface Immobilizing Antibody Via Desthiobiotin-avidin Interaction. 第2回生体医歯工学共同研究拠点国際シンポジウム 2017.11.09 東京都

  62. Masaya Yamamoto,Tsuyoshi Kimura,Akio kishida. Raman Spectroscopic Imaging Analysis of Decellularized Joint Tissue. 第2回生体医歯工学共同研究拠点国際シンポジウム 2017.11.09 東京都

  63. N. Nakamura, T. Kimura, Y. Hashimoto, T. Fujisato, T. Tsuji, A. Kishida . Periodontal tissue reconstruction using decellularized PDL matrix and 3D-printed tooth. 2016 TERMIS-Americas Conference & Exhibition 2016.12.11 San Diego,USA

  64. T. Kimura, N. Nakamura, Y. Hashimoto, S. Sakaguchi, S. Kimura, A. Kishida . Label-free capture and collection of target cells using a surface immobilizing antibody. 2016 TERMIS-Americas Conference & Exhibition 2016.12.11 San Diego,USA

  65. T. Kimura, N. Nakamura, Y. Hashimoto, S. Sakaguchi, S. Kimura, A. Kishida. Capture and release of lymphocyte on an antibody-immobilized surface. ICBS2016 2016.11.28 Tokyo,Japan

  66. T. Kimura, Y. Hashimoto, N. Nakamura, Y. Igari, T. Kubota, M. Kondo, S. Higashino, A. Kishida. Development of decellularaized tissues for controlling stem cell functions. The International Symposium on Visualization in Joining & Welding Science through Advanced Measurements and Simulation 2016.10.17 Osaka,Japan

  67. T. Kimura, P. Wu, H. Morita, N. Nakamura, Y. Hashimoto, A. Yamashita, S. Funamoto, T. Fujisato, A. Kishida. Mechanical and biological properties of small-diameter decellularized vascular graft covered by electrospun fibers. 9th International Conference on Fiber and Polymer Biotechnology 2016.09.07 osaka,Japan

  68. T. Kimura, P. Wu, N. Nakamura, Y. Hashimoto, A. Yamashita, S. Funamoto, T. Fujisato, A. Kishida. Development of small-diameter decellularized vascular graft combined with electrospun fibers. 2016 Annual Conference of the Asia-Pacific Society for Artificial Organs 2016.08.27 Tianjin,China

  69. N. Nakamura, T. Kimura, Y. Hashimoto, T. Fujisato, T. Tsuji, A. Kishida. Preparation of decellularized periodontal ligament for periodontal reconstruction. 2016 Annual Conference of the Asia-Pacific Society for Artificial Organs 2016.08.27 Tianjin,China

  70. A. Kishida. Reconstruction of periodontal tissue using decellularized biological tissue. 2nd Bone and Biomaterials Workshop 2016.08.07 Inari, Finland

  71. A. Kishida, Y. Zhang, K. Nam, T. Kimura. Preparation of gradient-type decellularized tissue/polymer complex for soft tissue-polymer interlinking device. CIMTEC2016 2016.06.05 Perugia, Italy

  72. T. Kimura, H. Morita, P. Wu, N. Nakamura, T. Fujisato, A. Kishida. Electrospun fibers covering of small-diameter decellularized vascular graft for compliance matching. 10th World Biomaterials Congress 2016.05.17 Montreal,Canada

  73. T. Kimura. Fabrication of decellularized aorta with electrospun fibers for small diameter vascular grafts. Pacifichem 2015 2015.12.15 Hawaii

  74. Tsuyoshi Kimura,Naoko Nakamura,Nao Sasaki,Shimon Sakaguchi,Shunsaku Kimura,Akio Kishida. Preparation of interface for specific capture of targets cells. BioMedical Devices, BioMEMS/NEMS and Applications 2015 2015.12.09 Fukuoka,Japan

  75. A.Kishida,N.Nakamura,A.Ito,K.Nam,T.Kimura,T.Fujisato,T.Tsuji. Periodontal reconstruction using decellularized periodontal tissue combined with artificial tooth. 4th TERMIS World Congress 2015.09.08 Boston,USA

  76. N.Nakamura,T.Kimura,K.Nam,T.Fujisato,T.Tsuji,H.Iwata,A.Kishida. Artificial Microenvironment of Decellularized Bone Marrow Induced Hematopoiesis. 2015 4th TERMIS WORLD CONGRESS 2015.09.08 Boston,USA

  77. T.Kimura,H.Morita,P.Wu,N.Nakamura,K.Nam,T.Fujisato,A.Kishida. A Small-diameter Decellularized Vascular Graft Covered with Electrospun Fibers. 2015 4th TERMIS WORLD CONGRESS 2015.09.08 Boston,USA

  78. Y.Zhang,K.Nam,T.Kimura,A.Kishida. Preparation of gradient decellullarized dermis-polymer complex for tissue interlinking device. 2015 4th TERMIS WORLD CONGRESS 2015.09.08 Boston,USA

  79. Naoko Nakamura,Tsuyoshi Kimura,Ai Ito,Toshiya Fujisato,Takashi Tsuji,Akio Kishida. Acellular Periodontal Ligament Matrix for Artificial Tooth Implant. 27th European Conference on Biomaterials 2015.08.30 Krakow,Poland

  80. T. Kimura,H. Morita,P.L. Wu,N. Nakamura,K. Nam,T. Fujisato,A. Kishida. Preparation of a Small Diameter Decellularized Blood Vessel Covered with Electrospun Nanofibers. Biomaterials International 2015 2015.06.01 Kenting,Taiwan

  81. Hiroko Morita,Tsuyoshi Kimura,PingLi Wu,Naoko Nakamura,Kwangwoo Nam,Toshiya Fujisato,Akio Kishida. Preparation of a small diameter decellularized blood vessel hybridized with nanofiber . 第64回高分子学会年次大会 2015.05.27 北海道

  82. Kimura T,Morita H,Wu P,Nakamura N,Fujisato T,Kishida A. Preparation of a small diameter decellularized blood vessel coverd with nanofibers by electrospinning. The 5th Asian Biomaterials Congress 2015.05.06 Taipei,Taiwan

  83. N. Nakamura,A. Ito,K. Nam,T. Kimura,T. Fujisato,T. Tsuji,A. Kishida. Preparation of Decellularized Mandible Bone with Periodontal Membrane for Periodontal Reconstruction. SFB 2015 ANNUAL MEETING AND EXPOSITION 2015.04.15 Charlotte, USA

  84. T.Kimura,H.Morita,P. Wu,N. Nakamura,K. Nam,T. Fujisato,A. Kishida. Preparation and Physical Properties of a Small Diameter Decellularized Vascular Graft Covered with Electrospun Fibers. SFB 2015 ANNUAL MEETING AND EXPOSITION 2015.04.15 Charlotte, USA

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Patents 【 display / non-display

  • METHOD FOR PRODUCING PARTICULATE DECELLULARIZED TISSUE

    Patent Number: EP3556406

  • ANTI-ADHESION MATERIAL AND ARTIFICIAL BIOLOGICAL MEMBRANE EACH COMPRISING DECELLULARIZED TISSUE

    Patent Number: KR 2376321

  • ANTI-ADHESION MATERIAL AND ARTIFICIAL BIOLOGICAL MEMBRANE EACH COMPRISING DECELLULARIZED TISSUE

    Patent Number: US11033661

  • ANTI-ADHESION MATERIAL AND SUBSTITUTE BIOMEMBRANE USING DECELLULARIZED TISSUE

    Patent Number: BR112017018772-8

  • ANTI-ADHESION MATERIAL AND SUBSTITUTE BIOMEMBRANE USING DECELLULARIZED TISSUE

    Patent Number: CA 2978401

  • HYBRID GEL CONTAINING PARTICULATE DECELLULARIZED TISSUE

    Patent Number: KR2339700

  • METHOD FOR PRODUCING PARTICULATE DECELLULARIZED TISSUE

    Patent Number: KR2240373

  • HYBRID GEL CONTAINING PARTICULATE DECELLULARIZED TISSUE

    Patent Number: CA2911592

  • METHOD FOR PRODUCING PARTICULATE DECELLULARIZED TISSUE

    Patent Number: EP2995325

  • HYBRID GEL CONTAINING PARTICULATE DECELLULARIZED TISSUE

    Patent Number: 201480038295.X

  • HYBRID GEL CONTAINING PARTICULATE DECELLULARIZED TISSUE

    Patent Number: 2995326

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Awards & Honors 【 display / non-display

  • TMDU-WISE Award Excellence Award,2023.02