Sasano Tetsuo, Yamazoe Masahiro, Ihara Kensuke, Mieda Ryota, Kobayashi Kazuma, Hamamoto Ryuji, Furukawa Tetsushi. Precision Medicine Targeting Atrial Fibrillation and Cardiogenic Embolism　Novel Risk Stratification for Atrial Fibrillation Focusing on Atrial Remodeling(和訳中) 日本循環器学会学術集会抄録集. 2020.07; 84回 Symposium10-3. ( ichushi )

Higashijima Yoshiki, Matsui Yusuke, Shimamura Teppei, Nakaki Ryo, Nagai Nao, Tsutsumi Shuichi, Abe Yohei, Link Verena M., Osaka Mizuko, Yoshida Masayuki, Watanabe Ryo, Tanaka Toshihiro, Taguchi Akashi, Miura Mai, Ruan Xiaoan, Li Guoliang, Inoue Tsuyoshi, Nangaku Masaomi, Kimura Hiroshi, Furukawa Tetsushi, Aburatani Hiroyuki, Wada Youichiro, Ruan Yijun, Glass Christopher K., Kanki Yasuharu. Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells EMBO JOURNAL. 2020.04; 39 (7):

Ihara Kensuke, Sasano Tetsuo, Takahashi Kentaro, Yamazoe Masahiro, Furukawa Tetsushi. Cardiac mechano-physiology: physiology and pathophysiology of the mechano-electrical coupling　Pannexin-1 Contributes to Maintenance of Cardiac Function against Acute Pressure-overload and Rapid Ventricular Pacing(和訳中) The Journal of Physiological Sciences. 2020.03; 70 (Suppl.1): S26. ( ichushi )

Kodama M, Furutani K, Kimura R, Ando T, Sakamoto K, Nagamori S, Ashihara T, Kurachi Y, Sekino Y, Furukawa T, Kanda Y, Kurokawa J. Systematic expression analysis of genes related to generation of action potentials in human iPS cell-derived cardiomyocytes J Pharmacol Sci. 2019.09; ( DOI )

Ebana Y, Sun Y, Yang X, Watanabe T, Makita S, Ozaki K, Tanaka T, Arai H, Furukawa T. Pathway analysis with genome-wide association study (GWAS) data detected the association of atrial fibrillation with the mTOR signaling pathway Int J Cardiol Heart Vasc.. 2019.09; 2019 (24): 100383. ( DOI )

Sugiura Seiryo, Okada Jun-Ichi, Yoshinaga Takashi, Kurokawa Junko, Washio Takumi, Furukawa Tetsushi, Sawada Kohei, Hisada Toshiaki. Physiome for organ function(KPS, Korea)　In silico screening system for drug-induced arrhythmogenic risk(和訳中) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S85. ( ichushi )

Yamada Noriaki, Asano Yoshihiro, Fujita Masashi, Yamazaki Satoru, Inanobe Atsushi, Matsuura Norio, Kobayashi Hatasu, Ohno Seiko, Ebana Yusuke, Tsukamoto Osamu, Ishino Saki, Takuwa Ayako, Kioka Hidetaka, Yamashita Toru, Hashimoto Norio, Zankov Dimitar P., Shimizu Akio, Asakura Masanori, Asanuma Hiroshi, Kato Hisakazu, Nishida Yuya, Miyashita Yohei, Shinomiya Haruki, Naiki Nobu, Hayashi Kenshi, Makiyama Takeru, Ogita Hisakazu, Miura Katsuyuki, Ueshima Hirotsugu, Komuro Issei, Yamagishi Masakazu, Hone Minoru, Kawakami Koichi, Furukawa Tetsushi, Koizumi Akio, Kurachi Yoshihisa, Sakata Yasushi, Minamino Tetsuo, Kitakaze Masafumi, Takashima Seiji. Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation CIRCULATION. 2019.04; 139 (18): 2157-2169. ( DOI )

井原 健介, 笹野 哲郎, 山添 正博, 古川 哲史. Intolerance to Rapid Ventricular Pacing and Coronary Hypoplasty in Pannexin-1 Knockout Mouse Heart(和訳中) 日本循環器学会学術集会抄録集. 2019.03; 83回 PJ113-2. ( ichushi )

古川 哲史, Ihara Kensuke, Abe Keiko, Yamazoe Masahiro, Takeuchi Jun, Sasano Tetsuo. Role of Gap-Junctional Channel, Pannexin, in I/R Pre-conditioning and Arrhythmias(和訳中) 日本循環器学会学術集会抄録集. 2019.03; 83回 SS04-2. ( ichushi )

Yamazoe Masahiro, Sasano Tetsuo, Nakamura Wakana, Ihara Kensuke, Takahashi Naomi, Hirao Kenzo, Furukawa Tetsushi. Rare Methylated Cell-free DNA Released from Cardiomyocytes Contributes to Systemic Inflammatory Response Accompanied with Atrial Fibrillation(和訳中) 日本循環器学会学術集会抄録集. 2019.03; 83回 FRS11-2. ( ichushi )

Asano Yoshihiro, Yamada Noriaki, Fujita Masashi, Kioka Hidetaka, Ohno Seiko, Furukawa Tetsushi, Sakata Yasushi, Kitakaze Masafumi, Takashima Seiji. Precision Medicine in Inherited Arrhythmias　New Insights into the Therapeutic Potential of a KACh Channel in Hereditary Sinus Bradycardia(和訳中) 日本循環器学会学術集会抄録集. 2019.03; 83回 SY17-5. ( ichushi )

千葉 里沙子, 山添 正博, 井原 健介, 小室 博明, 永井 亜希子, 古川 哲史, 笹野 哲郎. Local Injection of Charged Hydroxyapatite Nanoparticle Attenuates the Myocardial Injury in Murine Myocardial Infarction Model(和訳中) 日本循環器学会学術集会抄録集. 2019.03; 83回 PJ001-6. ( ichushi )

Hamada S, Hasegawa Y, Oono A, Suzuki A, Takahashi N, Nishimura T, Koyama T, Hagihara M, Tohda S, Furukawa T, Hirao K, Sasano T. Author Correction: Differential Assessment of Factor Xa Activity and Global Blood Coagulability Utilizing Novel Dielectric Coagulometry. Scientific reports. 2019.03; 9 (1): 4957. ( PubMed, DOI )

Ebana Y, Furukawa T. Networking analysis on superior vena cava arrhythmogenicity in atrial fibrillation Int J Cardiol Heart Vasc. 2019.02; 22 150-153. ( DOI )

Hori Yutaro, Tanimoto Yoko, Takahashi Satoru, Furukawa Tetsushi, Koshiba-Takeuchi Kazuko, Takeuchi Jun K.. Important cardiac transcription factor genes are accompanied by bidirectional long non-coding RNAs BMC GENOMICS. 2018.12; 19 (1): 967. ( PubMed, DOI )

Hori Y, Tanimoto Y, Takahashi S, Furukawa T, Koshiba-Takeuchi K, Takeuchi JK. Important cardiac transcription factor genes are accompanied by bidirectional long non-coding RNAs BMC Genomics. 2018.12; 19 (1): 867. ( DOI )

Hamada Satomi, Hasegawa Yuki, Oono Ai, Suzuki Anna, Takahashi Naomi, Nishimura Takuro, Koyama Takatoshi, Hagihara Michio, Tohda Shuji, Furukawa Tetsushi, Hirao Kenzo, Sasano Tetsuo. Differential Assessment of Factor Xa Activity and Global Blood Coagulability Utilizing Novel Dielectric Coagulometry SCIENTIFIC REPORTS. 2018.10; 8 (1): 16129. ( PubMed, DOI )

Jun-Ichi Okada, Takashi Yoshinaga, Junko Kurokawa, Takumi Washio, Tetsushi Furukawa, Kohei Sawada, Seiryo Sugiura, Toshiaki Hisada. Arrhythmic hazard map for a 3D whole-ventricle model under multiple ion channel block. Br. J. Pharmacol.. 2018.09; 175 (17): 3435-3452. ( PubMed, DOI )

Natsume Yu, Oaku Kasumi, Takahashi Kentaro, Nakamura Wakana, Oono Ai, Hamada Satomi, Yamazoe Masahiro, Ihara Kensuke, Sasaki Takeshi, Goya Masahiko, Hirao Kenzo, Furukawa Tetsushi, Sasano Tetsuo. ヒト由来試料と実験マウス由来試料の統合解析により心房細動のバイオマーカーとして新たな循環microRNAを特定した(Combined Analysis of Human and Experimental Murine Samples Identified Novel Circulating MicroRNAs as Biomarkers for Atrial Fibrillation) Circulation Journal. 2018.03; 82 (4): 965-973. ( ichushi )

Yamazoe Masahiro, Sasano Tetsuo, Nakamura Wakana, Takahashi Kentaro, Ihara Kensuke, Hirao Kenzo, Furukawa Tetsushi. 心房細動患者における無細胞DNAはマクロファージにおける炎症性サイトカインの発現を促進する(Cell Free DNA in Patients with Atrial Fibrillation Promotes Pro-Inflammatory Cytokine Expression in Macrophages) 日本循環器学会学術集会抄録集. 2018.03; 82回 FRS1-4. ( ichushi )

Ihara Kensuke, Sasano Tetsuo, Takahashi Kentaro, Yamazoe Masahiro, Furukawa Tetsushi. マウスではpannexin-1が電気的ペーシングおよび/または低酸素症下の心機能を維持する(Pannexin-1 Maintains Cardiac Function under the Electrical Pacing and/or Hypoxia in Mice) 日本循環器学会学術集会抄録集. 2018.03; 82回 PE033-7. ( ichushi )

Yu Natsume, Kasumi Oaku, Kentaro Takahashi, Wakana Nakamura, Ai Oono, Satomi Hamada, Masahiro Yamazoe, Kensuke Ihara, Takeshi Sasaki, Masahiko Goya, Kenzo Hirao, Tetsushi Furukawa, Tetsuo Sasano. Combined Analysis of Human and Experimental Murine Samples Identified Novel Circulating MicroRNAs as Biomarkers for Atrial Fibrillation. Circ. J.. 2018.02; ( PubMed, DOI )

Kensuke Ihara, Koji Sugiyama, Kentaro Takahashi, Masahiro Yamazoe, Tetsuo Sasano, Tetsushi Furukawa. Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping Journal of Visualized Experiments. 2018.02;

Ihara Kensuke, Sugiyama Koji, Takahashi Kentaro, Yamazoe Masahiro, Sasano Tetsuo, Furukawa Tetsushi. Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2018.02; (132): ( PubMed, DOI )

Yoshioka K, Kuroda S, Takahashi K, Sasano T, Furukawa T, Matsumura A. Calcification of joints and arteries with novel NT5E mutations with involvement of upper extremity arteries Vascular Medicine. 2017.12; 22 (6): 541-543.

Yusuke Ebana, Junichi Nitta, Yoshihide Takahashi, Shinsuke Miyazaki, Masahito Suzuki, Lian Liu, Kenzo Hirao, Eiichiro Kanda, Mitsuaki Isobe, Tetsushi Furukawa. Association of the Clinical and Genetic Factors With Superior Vena Cava Arrhythmogenicity in Atrial Fibrillation. Circ. J.. 2017.12; 82 (1): 71-77. ( PubMed, DOI )

Yoshioka Kenji, Kuroda Shunsuke, Takahashi Kentaro, Sasano Tetsuo, Furukawa Tetsushi, Matsumura Akihiko. Calcification of joints and arteries with novel NT5E mutations with involvement of upper extremity arteries VASCULAR MEDICINE. 2017.12; 22 (6): 541-543. ( PubMed, DOI )

Ebana Yusuke, Nitta Junichi, Takahashi Yoshihide, Miyazaki Shinsuke, Suzuki Masahito, Liu Lian, Hirao Kenzo, Kanda Eiichiro, Isobe Mitsuaki, Furukawa Tetsushi. 心房細動における上大静脈催不整脈性と臨床的・遺伝的因子との関連(Association of the Clinical and Genetic Factors With Superior Vena Cava Arrhythmogenicity in Atrial Fibrillation) Circulation Journal. 2017.12; 82 (1): 71-77. ( ichushi )

東島 佳毅, 神吉 康晴, 井上 剛, 南学 正臣, 古川 哲史, 和田 洋一郎. 血管内皮細胞における炎症性刺激に応じたmiRNA-ヒストン修飾ネットワーク機構 生命科学系学会合同年次大会. 2017.12; 2017年度 [4LT14-05(3P. ( ichushi )

Ebana Y, Ozaki K, Liu L, Hachiya H, Hirao K, Isobe M, Kubo M, Tanaka T, Furukawa T. Clinical utility and functional analysis of variants in atrial fibrillation-associated locus 4q25 Journal of Cardiology. 2017.10; 70 (4): 366-373.

Miyazaki S, Ebana Y, Liu L, Nakamura H, Hachiya H, Taniguchi H, Takagi T, Kajiyama T, Watanabe T, Igarashi M, Kusa S, Niida T, Iesaka Y, Furukawa T. Chromosome 4q25 variants and recurrence after second-generation cryoballoon ablation in patients with paroxysmal atrial fibrillation International Journal of Cardiology. 2017.10; 244 151-157.

Miyazaki Shinsuke, Ebana Yusuke, Liu Lian, Nakamura Hiroaki, Hachiya Hitoshi, Taniguchi Hiroshi, Takagi Takamitsu, Kajiyama Takatsugu, Watanabe Tomonori, Igarashi Miyako, Kusa Shigeki, Niida Takashi, Iesaka Yoshito, Furukawa Tetsushi. Chromosome 4q25 variants and recurrence after second-generation cryoballoon ablation in patients with paroxysmal atrial fibrillation INTERNATIONAL JOURNAL OF CARDIOLOGY. 2017.10; 244 151-157. ( PubMed, DOI )

Ebana Yusuke, Ozaki Kouichi, Liu Lian, Hachiya Hitoshi, Hirao Kenzo, Isobe Mitsuaki, Kubo Michiaki, Tanaka Toshihiro, Furukawa Tetsushi. 心房細動関連遺伝子座4q25におけるバリアントの臨床的有用性と機能解析(Clinical utility and functional analysis of variants in atrial fibrillation-associated locus 4q25) Journal of Cardiology. 2017.10; 70 (3-4): 366-373. ( ichushi )

Zaw KTT, Sato N, Ikeda S, Thu KS, Mieno MN, Arai T, Mori S, Furukawa T, Sasano T, Sawabe M, Tanaka M, Muramatsu M. Association of ZFHX3 gene variant with atrial fibrillation, cerebral infarction, and lung thromboembolism:An autopsy study Journal of Cardiology. 2017.08; 70 (2): 180-184.

Khin Thet Thet Zaw , Sato Noriko, Ikeda Shinobu, Kaung Si Thu , Naka Mieno Makiko, Arai Tomio, Mori Seijiro, Furukawa Tetsushi, Sasano Tetsuo, Sawabe Motoji, Tanaka Masashi, Muramatsu Masaaki. ZFHX3遺伝子変異と心房細動、脳梗塞、肺血栓塞栓症との関連　剖検研究(Association of ZFHX3 gene variation with atrial fibrillation, cerebral infarction, and lung thromboembolism: An autopsy study) Journal of Cardiology. 2017.08; 70 (1-2): 180-184. ( ichushi )

Li M, Kanda Y, Ashihara T, Sasano T, Nakai Y, Kodama M, Hayashi E, Sekino Y, Furukawa T, Kurokawa J. Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs Journal of Pharmacological Science. 2017.06; 134 (2): 75-85.

Low SK, Takahashi A, Ebana Y, Ozaki K, Christophersen IE, Ellinor PT; AFGen Consortium., Ogishima S, Yamamoto M, Satoh M, Sasaki M, Yamaji T, Iwasaki M, Tsugane S, Tanaka K, Naito M, Wakai K, Tanaka H, Furukawa T, Kubo M, Ito K, Kamatani Y, Tanaka . Identification of six new genetic loci associated with atrial fibrillation in the Japanese population Nature Genetics. 2017.06; 49 (6): 953-958.

Low Siew-Kee, Takahashi Atsushi, Ebana Yusuke, Ozaki Kouichi, Christophersen- Ingrid E., Ellinor Patrick T., Ogishima Soichi, Yamamoto Masayuki, Satoh Mamoru, Sasaki Makoto, Yamaji Taiki, Iwasaki Motoki, Tsugane Shoichiro, Tanaka Keitaro, Naito Mariko, Wakai Kenji, Tanaka Hideo, Furukawa Tetsushi, Kubo Michiaki, Ito Kaoru, Kamatani Yoichiro, Tanaka Toshihiro. Identification of six new genetic loci associated with atrial fibrillation in the Japanese population NATURE GENETICS. 2017.06; 49 (6): 953-+. ( PubMed, DOI )

Li Min, Kanda Yasunari, Ashihara Takashi, Sasano Tetsuo, Nakai Yuji, Kodama Masami, Hayashi Erina, Sekino Yuko, Furukawa Tetsushi, Kurokawa Junko. QT延長薬の評価に関する、多能性幹細胞由来心筋細胞におけるKCNJ2の過剰発現(Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs) Journal of Pharmacological Sciences. 2017.06; 134 (2): 75-85. ( ichushi )

Li Min, Kanda Yasunari, Ashihara Takashi, Sasano Tetsuo, Nakai Yuji, Kodama Masami, Hayashi Erina, Sekino Yuko, Furukawa Tetsushi, Kurokawa Junko. Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017.06; 134 (2): 75-85. ( PubMed, DOI )

Liu L, Ebana Y, Nitta J, Takahashi Y, Miyazaki S, Tanaka T, Komura M, Isobe M, Furukawa T. Genetic variants associated with susceptibility to atrial fibrillation in Japanese population Canadian Journal of Cardiology. 2017.04; 33 443-449.

Liu Lian, Ebana Yusuke, Nitta Jun-ichi, Takahashi Yoshihide, Miyazaki Shinsuke, Tanaka Toshihiro, Komura Masatoshi, Isobe Mitsuaki, Furukawa Tetsushi. Genetic Variants Associated With Susceptibility to Atrial Fibrillation in a Japanese Population CANADIAN JOURNAL OF CARDIOLOGY. 2017.04; 33 (4): 443-449. ( PubMed, DOI )

Ihara Kensuke, Sasano Tetsuo, Sugiyama Koji, Takahashi Kentaro, Furukawa Tetsushi. CRISPR/Cas9ベースのin vivoゲノム編集による生物学的ペースメーカーの作成(Generating Biological Pacemaker by CRISPR/Cas9 Based in Vivo Genome Editing) 日本循環器学会学術集会抄録集. 2017.03; 81回 PE-036. ( ichushi )

Kodama Masami, Fukuda Shun, Nagamori Shushi, Isozumi Noriyoshi, Fujizuka Miki, Kanai Yoshikatsu, Furukawa Tetsushi, Kurokawa Junko. 遅延整流性カリウムチャネルのカルシウム感受性における分子複合体形成の役割(Roles of macromolecular complex formation in calcium-sensitivity of the cardiac IKs channel) The Journal of Physiological Sciences. 2017.03; 67 (Suppl.1): S156. ( ichushi )

Fukuda Shun, Kodama Masami, Nagamori Shushi, Isozumi Noriyoshi, Fujizuka Miki, Kita Satomi, Iwamoto Takahiro, Kanai Yoshikatsu, Furukawa Tetsushi, Kurokawa Junko. 心臓IKsチャネルのカルシウム感受性における高分子複合体の役割(Roles of macromolecular complexes in calcium-sensitivity of the cardiac IKs channel) Journal of Pharmacological Sciences. 2017.03; 133 (3Suppl.): S166. ( ichushi )

古川 哲史, Liu Lian, Ebana Yusuke, Nitta Jun-ichi, Takahashi Yoshihida, Miyazaki Shinsuke, Komura Masatoshi, Tanaka Toshihiro, Isobe Mitsuaki. 心房細動の遺伝的背景(Genetic Background of Atrial Fibrillation) 日本循環器学会学術集会抄録集. 2017.03; 81回 TP2-1. ( ichushi )

Fukuda Shun, Kodama Masami, Nagamori Shushi, Isozumi Noriyoshi, Fujizuka Miki, Kita Satomi, Iwamoto Takahiro, Kanai Yoshikatsu, Furukawa Tetsushi, Kurokawa Junko. Roles of macromolecular complexes in calcium-sensitivity of the cardiac I-Ks channel JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017.03; 133 (3): S166.

Takahashi Kentaro, Sasano Tetsuo, Ihara Kensuke, Isobe Mitsuaki, Furukawa Tetsushi. Pannexin-1は「機械受容器」として急性圧負荷に対する心機能の維持に寄与する(Pannexin-1 Contributes to the Maintenance of Cardiac Function against Acute Pressure-overload as a 'Mechanosensor') 日本循環器学会学術集会抄録集. 2017.03; 81回 PE-439. ( ichushi )

Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Hattori T, Ohno S, Kodaira M, Suzuki T, Hashimoto H, Okata S, Tanaka A, Aizawa Y, Murata M, Aiba T, Makita N, Furukawa T, Shimizu W, Kodama I, Ogawa S, Kokubun N, Horigome H, Hoeir M, Kamiya K, Fukuda K. Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell derived cardiomyocytes Biochemical Biophysical Reports. 2017.01; 9 245-256. ( PubMed )

Kimura Y, Aiba T, Sasano T, Furukawa T, Kusano K, Shimizu W. IRX3 variant as a modifier of Brugada syndrome with frequent ventricular fibrillation. Heart Rhythm Case Report. 2016.11; 2 (6): 465-468.

Okata S, Yuasa S, Suzuki T, Ito S, Makita N, Yoshida T, Li M, Kurokawa J, Seki T, Egashira T, Aizawa Y, Kodaira M, Motoda C, Yozu G, Shimojima M, Hayashiji N, Hashimoto H, Kuroda Y, Tanaka A, Murata M, Aiba T, Shimizu W, Horie M, Kamiya K, Furukawa T, Fukuda K. Embryonic type Na+ channel -subunit, SCN3B masks the disease phenotype of Brugada syndrome Science Reports. 2016.09; 6 34198. ( DOI )

Yamazoe M, Furukawa T. Long-Term Prognosis of Catecholaminergic Polymorphic Ventricular Tachycardia Patients With Ryanodine Receptor (RYR2) Mutations Circulation Journal. 2016.08; 80 (9): 1892-1894.

Hasegawa Y, Hamada S, Nishimura T, Sasaki T, Ebana Y, Kawabata M, Goya M, Isobe M, Koyama T, Furukawa T, Hirao K, Sasano T. Novel dielectric coagulation identifies hypercoagulability in patients with a high CHADS2 score without atrial fibrillation PLoS One. 2016.06; 11 (6): e0156557. ( DOI )

Sugiyama K, Sasano T, Kurokawa J, Takahashi K, Okamura T, Kato N, Isobe M, Furukawa T. Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice International Heart Journal. 2016.05; 57 (3): 341-349.

Akiko Koizumi, Tetsuo Sasano, Wataru Kimura, Yoshihiro Miyamoto, Takeshi Aiba, Taisuke Ishikawa, Akihiko Nogami, Seiji Fukamizu, Harumizu Sakurada, Yoshihide Takahashi, Hiroaki Nakamura, Tomoyuki Ishikura, Haruhiko Koseki, Takuro Arimura, Akinori Kimura, Kenzo Hirao, Mitsuaki Isobe, Wataru Shimizu, Naoyuki Miura, Tetsushi Furukawa. Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. European Heart Journal. 2016.05; 37 (18): 1469-1475. ( PubMed, DOI )

Lopez-Redondo F, Kurokawa J, Nomura F, Kaneko T, Hamada T, Furukawa T, Yasuda K.. A distribution analysis of action potential parameters obtained from patch-clamped human stem cell-derived cardiomyocytes. Journal Pharmacological Science. 2016.04; 8613 (16): 30032-30039. ( PubMed, DOI )

Takahashi K, Sasano T, Sugiyama K, Kurokawa J, Tamura N, Soejima Y, Sawabe M, Isobe M, Furukawa T. High-fat diet increases vulnerability to atrial arrhythmia by conduction disturbance via miR-27b Journal of Molecular Cellular cardiology. 2016.01; 90 38-46. ( DOI )

Yoshioka S, Usami T, Kikuta J, Ishii M, Sasano T, Sugiyama K, Furukawa T, Nakasho E, Takayanagi H, Tedder T, Karasuyama H, Kiyawami A, Adachi T.. Intravital imaging of Ca2+ signals in lymphocytes of Ca2+ biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Science Reports. 2016.01; 6 18738. ( PubMed, DOI )

Kurokawa J, Kodama M, Clancy CE and Furukawa T. Sex hormonal regulation of cardiac ion channels in drug-induced QT syndromes Pharmacology & Therapeutics. 2016; 168 23-28.

Yamakawa H, Muraoka N, Miyamoto K, Sadahiro T, Isomi M, Haginiwa S, Kojima H, Umei T, Akiyama M, Kuishi Y, Kurokawa J, Furukawa T, Fukuda K, Ieda M. Fibroblast growth factors and vascular endothelial growth factor promote cardiac reprogramming under defined conditions Stem Cell Reports. 2015.12; 5 (6): 1128-1142. ( PubMed, DOI )

Saito Y, Nakamura K, Yoshida M, Sugiyama H, Ohe T, Kurokawa J, Furukawa T, Takano M, Nagase S, Morita H, Kusano KF, Ito H. Enhancement of spontaneous activity by HCN4 overexpression in mouse embryonic stem cell-derived cardiomyocytes – A possible biological pacemaker. PLoS ONE. 2015.09; 10 (9): e0138193. ( PubMed, DOI )

2. Okada J, Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T. Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator Science Advance. 2015.05; 1 e1400142.

Kurokawa J, Sasano T, Kodama M, Li M, Ebana Y, Harada N, Honda S, Nakaya H, Furukawa T. Aromatase knockout mice reveal an impact of estrogen on drug-induced alternation of murine electrocardiography parameters The Journal of Toxicological Sciences. 2015.03; 40 (3): 339-348. ( DOI )

Kawabata M, Yokoyama Y, Sasaki T, Tao S, Ihara K, Shirai Y, Sasano T, Goya M, Furukawa T, Isobe M, Hirao K. Severe istrogenic bradycardiac related to the combined use of beta-blocking agents and sodium channel blockers Clinical Pharmacology. 2015.02; 7 29-36. ( DOI )

Atsushi Tanaka, Shinsuke Yuasa, Giulia Mearini, Toru Egashira, Tomohisa Seki, Masaki Kodaira, Dai Kusumoto, Yusuke Kuroda, Shinichiro Okata, Tomoyuki Suzuki, Taku Inohara, Takuro Arimura, Shinji Makino, Kensuke Kimura, Akinori Kimura, Tetsushi Furukawa, Lucie Carrier, Koichi Node, Keiichi Fukuda. Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes. J Am Heart Assoc. 2014.12; 3 (6): e001263. ( PubMed, DOI )

Tomohiro Hayakawa, Takeshi Kunihiro, Tomoko Ando, Seiji Kobayashi, Eriko Matsui, Hiroaki Yada, Yasunari Kanda, Junko Kurokawa, Tetsushi Furukawa. Image-based evaluation of contraction-relaxation kinetics of human-induced pluripotent stem cell-derived cardiomyocytes: Correlation and complementarity with extracellular electrophysiology. J. Mol. Cell. Cardiol.. 2014.12; 77 178-191. ( PubMed, DOI )

Moritz F Sinner, Nathan R Tucker, Kathryn L Lunetta, Kouichi Ozaki, J Gustav Smith, Stella Trompet, Joshua C Bis, Honghuang Lin, Mina K Chung, Jonas B Nielsen, Steven A Lubitz, Bouwe P Krijthe, Jared W Magnani, Jiangchuan Ye, Michael H Gollob, Tatsuhiko Tsunoda, Martina Müller-Nurasyid, Peter Lichtner, Annette Peters, Elena Dolmatova, Michiaki Kubo, Jonathan D Smith, Bruce M Psaty, Nicholas L Smith, J Wouter Jukema, Daniel I Chasman, Christine M Albert, Yusuke Ebana, Tetsushi Furukawa, Peter W Macfarlane, Tamara B Harris, Dawood Darbar, Marcus Dörr, Anders G Holst, Jesper H Svendsen, Albert Hofman, Andre G Uitterlinden, Vilmundur Gudnason, Mitsuaki Isobe, Rainer Malik, Martin Dichgans, Jonathan Rosand, David R Van Wagoner, , , Emelia J Benjamin, David J Milan, Olle Melander, Susan R Heckbert, Ian Ford, Yongmei Liu, John Barnard, Morten S Olesen, Bruno H C Stricker, Toshihiro Tanaka, Stefan Kääb, Patrick T Ellinor. Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Circulation. 2014.10; 130 (15): 1225-1235. ( PubMed, DOI )

Shinichiro Okata, Shinsuke Yuasa, Teiichi Yamane, Tetsushi Furukawa, Keiichi Fukuda. The generation of induced pluripotent stem cells from a patient with KCNH2 G603D, without LQT2 disease associated symptom. J. Med. Dent. Sci.. 2013; 60 (1): 17-22. ( PubMed )

Mahoko Asayama, Junko Kurokawa, Kiyoshi Shirakawa, Hisashi Okuyama, Toshiki Kagawa, Jun-ichi Okada, Seiryo Sugiura, Toshiaki Hisada, Tetsushi Furukawa. Effects of an hERG activator, ICA-105574, on electrophysiological properties of canine hearts. J. Pharmacol. Sci.. 2013; 121 (1): 1-8. ( PubMed )

Junko Kurokawa, Tetsushi Furukawa. Non-genomic action of sex steroid hormones and cardiac repolarization. Biol. Pharm. Bull.. 2013; 36 (1): 8-12. ( PubMed )

Toru Egashira, Shinsuke Yuasa, Tomoyuki Suzuki, Yoshiyasu Aizawa, Hiroyuki Yamakawa, Tomohiro Matsuhashi, Yohei Ohno, Shugo Tohyama, Shinichiro Okata, Tomohisa Seki, Yusuke Kuroda, Kojiro Yae, Hisayuki Hashimoto, Tomofumi Tanaka, Fumiyuki Hattori, Toshiaki Sato, Shunichiro Miyoshi, Seiji Takatsuki, Mitsushige Murata, Junko Kurokawa, Tetsushi Furukawa, Naomasa Makita, Takeshi Aiba, Wataru Shimizu, Minoru Horie, Kaichiro Kamiya, Itsuo Kodama, Satoshi Ogawa, Keiichi Fukuda. Disease characterization using LQTS-specific induced pluripotent stem cells. Cardiovasc. Res.. 2012.09; 95 (4): 419-429. ( PubMed, DOI )

Patrick T Ellinor, Kathryn L Lunetta, Christine M Albert, Nicole L Glazer, Marylyn D Ritchie, Albert V Smith, Dan E Arking, Martina Müller-Nurasyid, Bouwe P Krijthe, Steven A Lubitz, Joshua C Bis, Mina K Chung, Marcus Dörr, Kouichi Ozaki, Jason D Roberts, J Gustav Smith, Arne Pfeufer, Moritz F Sinner, Kurt Lohman, Jingzhong Ding, Nicholas L Smith, Jonathan D Smith, Michiel Rienstra, Kenneth M Rice, David R Van Wagoner, Jared W Magnani, Reza Wakili, Sebastian Clauss, Jerome I Rotter, Gerhard Steinbeck, Lenore J Launer, Robert W Davies, Matthew Borkovich, Tamara B Harris, Honghuang Lin, Uwe Völker, Henry Völzke, David J Milan, Albert Hofman, Eric Boerwinkle, Lin Y Chen, Elsayed Z Soliman, Benjamin F Voight, Guo Li, Aravinda Chakravarti, Michiaki Kubo, Usha B Tedrow, Lynda M Rose, Paul M Ridker, David Conen, Tatsuhiko Tsunoda, Tetsushi Furukawa, Nona Sotoodehnia, Siyan Xu, Naoyuki Kamatani, Daniel Levy, Yusuke Nakamura, Babar Parvez, Saagar Mahida, Karen L Furie, Jonathan Rosand, Raafia Muhammad, Bruce M Psaty, Thomas Meitinger, Siegfried Perz, H-Erich Wichmann, Jacqueline C M Witteman, W H Linda Kao, Sekar Kathiresan, Dan M Roden, Andre G Uitterlinden, Fernando Rivadeneira, Barbara McKnight, Marketa Sjögren, Anne B Newman, Yongmei Liu, Michael H Gollob, Olle Melander, Toshihiro Tanaka, Bruno H Ch Stricker, Stephan B Felix, Alvaro Alonso, Dawood Darbar, John Barnard, Daniel I Chasman, Susan R Heckbert, Emelia J Benjamin, Vilmundur Gudnason, Stefan Kääb. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat. Genet.. 2012.06; 44 (6): 670-675. ( PubMed, DOI )

Junko Kurokawa, Masami Kodama, Tetsushi Furukawa, Colleen E Clancy. Sex and gender aspects in antiarrhythmic therapy. Handb Exp Pharmacol. 2012; (214): 237-263. ( PubMed, DOI )

Sakiko Oishi, Tetsuo Sasano, Yumiko Tateishi, Noriko Tamura, Mitsuaki Isobe, Tetsushi Furukawa. Stretch of atrial myocytes stimulates recruitment of macrophages via ATP released through gap-junction channels. J. Pharmacol. Sci.. 2012; 120 (4): 296-304. ( PubMed )

Junko Kurokawa, Tetsushi Furukawa. Region- and condition-dependence of the membrane and Ca2+ clocks in the sinus node. Circ. J.. 2012; 76 (2): 293-294. ( PubMed )

Hiroki Sugiyama, Kazufumi Nakamura, Hiroshi Morita, Satoshi Akagi, Yoshinori Tani, Yusuke Katayama, Nobuhiro Nishii, Toru Miyoshi, Satoshi Nagase, Kunihisa Kohno, Kengo Fukushima Kusano, Tohru Ohe, Junko Kurokawa, Tetsushi Furukawa, Hiroshi Ito. Circulating KCNH2 current-activating factor in patients with heart failure and ventricular tachyarrhythmia. PLoS ONE. 2011; 6 (5): e19897. ( PubMed, DOI )

Kenji Yamashiro, Tetsuo Sasano, Katsuyoshi Tojo, Iyuki Namekata, Junko Kurokawa, Naoki Sawada, Takayoshi Suganami, Yasutomi Kamei, Hikaru Tanaka, Naoko Tajima, Kazunori Utsunomiya, Yoshihiro Ogawa, Tetsushi Furukawa. Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages. Biochem. Biophys. Res. Commun.. 2010.07; 398 (2): 284-289. ( PubMed, DOI )

Tokuhisa Uejima, Akira Koike, Hitoshi Sawada, Tadanori Aizawa, Shigeo Ohtsuki, Motonao Tanaka, Tetsushi Furukawa, Alan G Fraser. A new echocardiographic method for identifying vortex flow in the left ventricle: numerical validation. Ultrasound Med Biol. 2010.05; 36 (5): 772-788. ( PubMed, DOI )

Pei-Chi Yang, Junko Kurokawa, Tetsushi Furukawa, Colleen E Clancy. Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study. PLoS Comput. Biol.. 2010.01; 6 (1): e1000658. ( PubMed, DOI )

Kaihara A, Sunami A, Kurokawa J, Furukawa T. A genetically encoded bioluminescent indicator for the sodium channel activity in living cells J Am Chem Soc. 2009; 131 (12): 4188-4189. ( PubMed, DOI )

Asada K, Kurokawa J, Furukawa T. Redox- and calmodulin-dependent S-nitrosylation of the KCNQ1 channel J Biol Chem. 2009; 284 (9): 6014-6020. ( PubMed, DOI )

Kurokawa J, Suzuki T, Furukawa T. New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles: acute effects of female hormones on cardiac ion channels and cardiac repolarization J Pharmacol Sci. 2009; 109 (3): 334-340. ( PubMed )

Kakusaka S, Asayama M, Kaihara A, Sasano T, Suzuki T, Kurokawa J, Furukawa T. A receptor-independent effect of estrone sulfate on the HERG channel J Pharmacol Sci. 2009; 109 (1): 152-156. ( PubMed )

Kurokawa J, Bankston JR, Kaihara A, Chen L, Furukawa T, Kass RS. KCNE variants reveal a critical role of the beta subunit carboxyl terminus in PKA-dependent regulation of the IKs potassium channel Channels (Austin). 2009; 3 (1): 16-24. ( PubMed )

Kaihara A, Umezawa Y, Furukawa T. Bioluminescent indicators for Ca2+ based on split Renilla luciferase complementation in living cells Anal Sci. 2008; 24 (11): 1405-1408. ( PubMed )

Kurokawa J, Tamagawa M, Harada N, Honda S, Bai CX, Nakaya H, Furukawa T. Acute effects of oestrogen on the guinea pig and human IKr channels and drug-induced prolongation of cardiac repolarization J Physiol (Lond). 2008; 586 (Pt 12): 2961-2973. ( PubMed, DOI )

Furukawa T, Kurokawa J. Non-genomic regulation of cardiac ion channels by sex hormones Cardiovascular & hematological disorders drug targets. 2008; 8 (4): 245-251. ( PubMed )

Tani Y, Miura D, Kurokawa J, Nakamura K, Ouchida M, Shimizu K, Ohe T, Furukawa T. T75M-KCNJ2 mutation causing Andersen-Tawil syndrome enhances inward rectification by changing Mg2+ sensitivity J Mol Cell Cardiol. 2007; 43 (2): 187-196. ( PubMed, DOI )

Nakamura H, Kurokawa J, Bai CX, Asada K, Xu J, Oren RV, Zhu ZI, Clancy CE, Isobe M, Furukawa T. Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study Circulation. 2007; 116 (25): 2913-2922. ( PubMed, DOI )

Asaoka H, Kurokawa J, Furukawa T, Shimokado K. High glucose concentrations impair the activation of K+ channels and proteases in undifferentiated THP-1 monocytes J Med Dent Sci. 2007; 54 (1): 97-102. ( PubMed )

Nakamura K, Katayama Y, Kusano KF, Haraoka K, Tani Y, Nagase S, Morita H, Miura D, Fujimoto Y, Furukawa T, Ueda K, Aizawa Y, Kimura A, Kurachi Y, Ohe T. Anti-KCNH2 antibody-induced long QT syndrome: novel acquired form of long QT syndrome J Am Coll Cardiol. 2007; 50 (18): 1808-1809. ( PubMed, DOI )

Furukawa T, Kurokawa J. Regulation of cardiac ion channels via non-genomic action of sex steroid hormones: implication for the gender difference in cardiac arrhythmias Pharmacol Ther. 2007; 115 (1): 106-115. ( PubMed, DOI )

Furukawa T, Kurokawa J. Potassium channel remodeling in cardiac hypertrophy J Mol Cell Cardiol. 2006; 41 (5): 753-761. ( PubMed, DOI )

Furukawa T, Bai CX, Kaihara A, Ozaki E, Kawano T, Nakaya Y, Awais M, Sato M, Umezawa Y, Kurokawa J. Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones Mol Pharmacol. 2006; 70 (6): 1916-1924. ( PubMed, DOI )

Bai CX, Kurokawa J, Tamagawa M, Nakaya H, Furukawa T. Nontranscriptional regulation of cardiac repolarization currents by testosterone Circulation. 2005; 112 (12): 1701-1710. ( PubMed, DOI )

Bai CX, Namekata I, Kurokawa J, Tanaka H, Shigenobu K, Furukawa T. Role of nitric oxide in Ca2+ sensitivity of the slowly activating delayed rectifier K+ current in cardiac myocytes Circ Res. 2005; 96 (1): 64-72. ( PubMed, DOI )

Kurokawa J, Furukawa T. [Protein modification of cardiac potassium channels and lethal arrhythmias] Nippon Yakurigaku Zasshi. 2005; 126 (4): 273-279. ( PubMed )

Yoneda K, Furukawa T, Zheng YJ, Momoi T, Izawa I, Inagaki M, Manabe M, Inagaki N. An autocrine/paracrine loop linking keratin 14 aggregates to tumor necrosis factor alpha-mediated cytotoxicity in a keratinocyte model of epidermolysis bullosa simplex J Biol Chem. 2004; 279 (8): 7296-7303. ( PubMed, DOI )

Bai CX, Takahashi K, Masumiya H, Sawanobori T, Furukawa T. Nitric oxide-dependent modulation of the delayed rectifier K+ current and the L-type Ca2+ current by ginsenoside Re, an ingredient of Panax ginseng, in guinea-pig cardiomyocytes Br J Pharmacol. 2004; 142 (3): 567-575. ( PubMed, DOI )

Hori K, Takahashi Y, Horikawa N, Furukawa T, Tsukada K, Takeguchi N, Sakai H. Is the ClC-2 chloride channel involved in the Cl- secretory mechanism of gastric parietal cells? FEBS Lett. 2004; 575 (1-3): 105-108. ( PubMed, DOI )

Noda Y, Horikawa S, Furukawa T, Hirai K, Katayama Y, Asai T, Kuwahara M, Katagiri K, Kinashi T, Hattori M, Minato N, Sasaki S. Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1 FEBS Lett. 2004; 568 (1-3): 139-145. ( PubMed, DOI )

Hiramatsu M, Wu LM, Hirano Y, Kawano S, Furukawa T, Hiraoka M. Block of HERG current expressed in HEK293 cells by the Na+-channel blocker cibenzoline Heart Vessels. 2004; 19 (3): 137-143. ( PubMed, DOI )

Bai CX, Sunami A, Namiki T, Sawanobori T, Furukawa T. Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes Eur J Pharmacol. 2003; 476 (1-2): 35-44. ( PubMed )

Zheng YJ, Furukawa T, Tajimi K, Inagaki N. Cl- channel blockers inhibit transition of quiescent (G0) fibroblasts into the cell cycle J Cell Physiol. 2003; 194 (3): 376-383. ( PubMed, DOI )

Furukawa T. [Various functions of ClC-type Cl- channels] Nippon Yakurigaku Zasshi. 2003; 122 (5): 375-383. ( PubMed )

Masumiya H, Yamamoto H, Hemberger M, Tanaka H, Shigenobu K, Chen SR, Furukawa T. The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors FEBS Lett. 2003; 553 (1-2): 141-144. ( PubMed )

Hiramatsu M, Furukawa T, Sawanobori T, Hiraoka M. Ion channel remodeling in cardiac hypertrophy is prevented by blood pressure reduction without affecting heart weight increase in rats with abdominal aortic banding J Cardiovasc Pharmacol. 2002; 39 (6): 866-874. ( PubMed )

Ogura T, Furukawa T, Toyozaki T, Yamada K, Zheng YJ, Katayama Y, Nakaya H, Inagaki N. ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC FASEB J. 2002; 16 (8): 863-865. ( PubMed, DOI )

Zheng YJ, Furukawa T, Ogura T, Tajimi K, Inagaki N. M phase-specific expression and phosphorylation-dependent ubiquitination of the ClC-2 channel J Biol Chem. 2002; 277 (35): 32268-32273. ( PubMed, DOI )

Furukawa T, Ogura T, Zheng YJ, Tsuchiya H, Nakaya H, Katayama Y, Inagaki N. Phosphorylation and functional regulation of ClC-2 chloride channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase J Physiol (Lond). 2002; 540 (Pt 3): 883-893. ( PubMed )

Furukawa T, Ono Y, Tsuchiya H, Katayama Y, Bang ML, Labeit D, Labeit S, Inagaki N, Gregorio CC. Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system J Mol Biol. 2001; 313 (4): 775-784. ( PubMed, DOI )

Nakajima T, Kurabayashi M, Ohyama Y, Kaneko Y, Furukawa T, Itoh T, Taniguchi Y, Tanaka T, Nakamura Y, Hiraoka M, Nagai R. Characterization of S818L mutation in HERG C-terminus in LQT2. Modification of activation-deactivation gating properties FEBS Lett. 2000; 481 (2): 197-203. ( PubMed )

Nakajima T, Furukawa T, Hirano Y, Tanaka T, Sakurada H, Takahashi T, Nagai R, Itoh T, Katayama Y, Nakamura Y, Hiraoka M. Voltage-shift of the current activation in HERG S4 mutation (R534C) in LQT2 Cardiovasc Res. 1999; 44 (2): 283-293. ( PubMed )

Nakajima T, Furukawa T, Tanaka T, Katayama Y, Nagai R, Nakamura Y, Hiraoka M. Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivation Circ Res. 1998; 83 (4): 415-422. ( PubMed )

Furukawa T, Ogura T, Katayama Y, Hiraoka M. Characteristics of rabbit ClC-2 current expressed in Xenopus oocytes and its contribution to volume regulation Am J Physiol. 1998; 274 (2 Pt 1): C500-12. ( PubMed )

Hiraoka M, Furukawa T. Functional Modulation of Cardiac ATP-Sensitive K(+) Channels News Physiol Sci. 1998; 13 131-137. ( PubMed )

Hiraoka M, Kawano S, Hirano Y, Furukawa T. Role of cardiac chloride currents in changes in action potential characteristics and arrhythmias Cardiovasc Res. 1998; 40 (1): 23-33. ( PubMed )

Furukawa T, Yamane T, Terai T, Katayama Y, Hiraoka M. Functional linkage of the cardiac ATP-sensitive K+ channel to the actin cytoskeleton Pflugers Arch. 1996; 431 (4): 504-512. ( PubMed )

Hiraoka M, Sawanobori T, Kawano S, Hirano Y, Furukawa T. Functions of cardiac ion channels under normal and pathological conditions Jpn Heart J. 1996; 37 (5): 693-707. ( PubMed )

Yamane T, Furukawa T, Hiraoka M. 4-Aminopyridine block of the noninactivating cloned K+ channel Kv1.5 expressed in Xenopus oocytes Am J Physiol. 1995; 269 (2 Pt 2): H556-64. ( PubMed )

Yamane T, Furukawa T, Hiraoka M. [Molecular structure and function of voltage-dependent K channels] Tanpakushitsu Kakusan Koso. 1995; 40 (15): 2280-2287. ( PubMed )

Furukawa T, Horikawa S, Terai T, Ogura T, Katayama Y, Hiraoka M. Molecular cloning and characterization of a novel truncated from (ClC-2 beta) of ClC-2 alpha (ClC-2G) in rabbit heart FEBS Lett. 1995; 375 (1-2): 56-62. ( PubMed )

Furukawa T, Virág L, Furukawa N, Sawanobori T, Hiraoka M. Mechanism for reactivation of the ATP-sensitive K+ channel by MgATP complexes in guinea-pig ventricular myocytes J Physiol (Lond). 1994; 479 ( Pt 1) 95-107. ( PubMed )

Nitta J, Furukawa T, Marumo F, Sawanobori T, Hiraoka M. Subcellular mechanism for Ca(2+)-dependent enhancement of delayed rectifier K+ current in isolated membrane patches of guinea pig ventricular myocytes Circ Res. 1994; 74 (1): 96-104. ( PubMed )

Uchida S, Sasaki S, Furukawa T, Hiraoka M, Imai T, Hirata Y, Marumo F. Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla J Biol Chem. 1994; 269 (29): 19192. ( PubMed )

Furukawa T, Myerburg RJ, Furukawa N, Kimura S, Bassett AL. Metabolic inhibition of ICa,L and IK differs in feline left ventricular hypertrophy Am J Physiol. 1994; 266 (3 Pt 2): H1121-31. ( PubMed )

Furukawa T, Fan Z, Sawanobori T, Hiraoka M. Modification of the adenosine 5'-triphosphate-sensitive K+ channel by trypsin in guinea-pig ventricular myocytes J Physiol (Lond). 1993; 466 707-726. ( PubMed )

Virág L, Furukawa T, Hiraoka M. Modulation of the effect of glibenclamide on KATP channels by ATP and ADP Mol Cell Biochem. 1993; 119 (1-2): 209-215. ( PubMed )

Furukawa T, Virág L, Sawanobori T, Hiraoka M. Stilbene disulfonates block ATP-sensitive K+ channels in guinea pig ventricular myocytes J Membr Biol. 1993; 136 (3): 289-302. ( PubMed )

Fan Z, Furukawa T, Sawanobori T, Makielski JC, Hiraoka M. Cytoplasmic acidosis induces multiple conductance states in ATP-sensitive potassium channels of cardiac myocytes J Membr Biol. 1993; 136 (2): 169-179. ( PubMed )

Hiraoka M, Fan Z, Furukawa T, Nakayama K, Sawanobori T. Activation and reactivation of the ATP-sensitive K+ channel of the heart can be modified by drugs Cardiovasc Drugs Ther. 1993; 7 Suppl 3 593-598. ( PubMed )

Furukawa T, Bassett AL, Furukawa N, Kimura S, Myerburg RJ. The ionic mechanism of reperfusion-induced early afterdepolarizations in feline left ventricular hypertrophy J Clin Invest. 1993; 91 (4): 1521-1531. ( PubMed, DOI )

Yamane T, Furukawa T, Horikawa S, Hiraoka M. External pH regulates the slowly activating potassium current IsK expressed in Xenopus oocytes FEBS Lett. 1993; 319 (3): 229-232. ( PubMed )

Uchida S, Sasaki S, Furukawa T, Hiraoka M, Imai T, Hirata Y, Marumo F. Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla J Biol Chem. 1993; 268 (6): 3821-3824. ( PubMed )

Myerburg RJ, Kozlovskis PL, Kimura S, Furukawa T, Bassett AL. Studies of autonomic properties after healing of experimental myocardial infarction G Ital Cardiol. 1992; 22 (5): 623-628. ( PubMed )

Furukawa T, Kimura S, Furukawa N, Bassett AL, Myerburg RJ. Potassium rectifier currents differ in myocytes of endocardial and epicardial origin Circ Res. 1992; 70 (1): 91-103. ( PubMed )

Furukawa T, Ito H, Nitta J, Tsujino M, Adachi S, Hiroe M, Marumo F, Sawanobori T, Hiraoka M. Endothelin-1 enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes Circ Res. 1992; 71 (5): 1242-1253. ( PubMed )

Nitta J, Sunami A, Furukawa T, Marumo F, Sawanobori T, Hiraoka M. Combined class I antiarrhythmic agents have differential effects on tonic and use dependent block of maximum rate of depolarisation of action potentials in guinea pig cardiac muscle Cardiovasc Res. 1992; 26 (5): 462-469. ( PubMed )

Furukawa T, Myerburg RJ. Mechanisms of arrhythmias in chronic ischemic heart disease Cardiovasc Clin. 1992; 22 (1): 19-43. ( PubMed )

Furukawa T, Moroe K, Mayrovitz HN, Sampsell R, Furukawa N, Myerburg RJ. Arrhythmogenic effects of graded coronary blood flow reductions superimposed on prior myocardial infarction in dogs Circulation. 1991; 84 (1): 368-377. ( PubMed )

Furukawa N, Bassett AL, Furukawa T, Myerburg RJ, Kimura S. Hypertrophy alters effect of Ins(1,4,5)P3 on Ca2+ release in skinned rat heart muscle Am J Physiol. 1991; 260 (5 Pt 2): H1612-8. ( PubMed )

Cuevas J, Bassett AL, Cameron JS, Furukawa T, Myerburg RJ, Kimura S. Effect of H+ on ATP-regulated K+ channels in feline ventricular myocytes Am J Physiol. 1991; 261 (3 Pt 2): H755-61. ( PubMed )

Kimura S, Bassett AL, Furukawa T, Furukawa N, Myerburg RJ. Differences in the effect of metabolic inhibition on action potentials and calcium currents in endocardial and epicardial cells Circulation. 1991; 84 (2): 768-777. ( PubMed )

Furukawa T, Kimura S, Furukawa N, Bassett AL, Myerburg RJ. Role of cardiac ATP-regulated potassium channels in differential responses of endocardial and epicardial cells to ischemia Circ Res. 1991; 68 (6): 1693-1702. ( PubMed )

Furukawa T, Myerburg RJ, Furukawa N, Bassett AL, Kimura S. Differences in transient outward currents of feline endocardial and epicardial myocytes Circ Res. 1990; 67 (5): 1287-1291. ( PubMed )

Furukawa T, Kimura S, Catstellanos A, Bassett AL, Myerburg RJ. In vivo induction of "focal" triggered ventricular arrhythmias and responses to overdrive pacing in the canine heart Circulation. 1990; 82 (2): 549-559. ( PubMed )

Kimura S, Bassett AL, Furukawa T, Furukawa N, Myerburg RJ. Effect of acidosis on contractile system in skinned fibers of hypertrophied rat heart Am J Physiol. 1990; 259 (4 Pt 2): H1044-9. ( PubMed )

Kimura S, Bassett AL, Furukawa T, Cuevas J, Myerburg RJ. Electrophysiological properties and responses to simulated ischemia in cat ventricular myocytes of endocardial and epicardial origin Circ Res. 1990; 66 (2): 469-477. ( PubMed )

Furukawa T, Rozanski JJ, Moroe K, Gosselin AJ, Lister JW. Efficacy of procainamide on ventricular tachycardia: relation to prolongation of refractoriness and slowing of conduction Am Heart J. 1989; 118 (4): 702-708. ( PubMed )

Furukawa T, Herscovici H, Desai T, Sampsell R, Nogami A, Moroe K, Rozanski JJ, Lister JW. Rapid assessment of rate and antiarrhythmic drug effect on the myocardium using asymmetric biphasic pulse stimulation Pacing Clin Electrophysiol. 1989; 12 (1 Pt 1): 52-64. ( PubMed )

Furukawa T, Rozanski JJ, Nogami A, Moroe K, Gosselin AJ, Lister JW. Time-dependent risk of and predictors for cardiac arrest recurrence in survivors of out-of-hospital cardiac arrest with chronic coronary artery disease Circulation. 1989; 80 (3): 599-608. ( PubMed )

Nogami A, Rozanski JJ, Furukawa T, Gosselin AJ, Lister JW. Triphasic time dependence of prognostic markers in patients with sustained ventricular tachyarrhythmias and coronary artery disease Jpn Circ J. 1989; 53 (9): 1061-1071. ( PubMed )

Furukawa T, Rozanski JJ, Moroe K, Gosselin AJ, Lister JW. Predictors of sustained ventricular tachycardia inducibility in patients with nonsustained ventricular tachycardia and chronic coronary artery disease Am Heart J. 1989; 117 (5): 1050-1059. ( PubMed )

Furukawa T, Taniguchi K, Takeuchi J. The use of evoked endocardial response for assessment of antiarrhythmic drug effects on myocardium Bull Tokyo Med Dent Univ. 1988; 35 (3): 33-44. ( PubMed )

Tetsushi Furukawa. Mechanisms of arrhythmias in heart failure and new advances in its management. Annual Meeting of the Japanese Heart Rhythm Society 2016 2016.07.16 Sapporo, Hokkaido

Lian Liu, Yusuke Ebana, Jun-ichi Nitta, Yoshihide Takahashi, Shinsuke Miyazaki, Toshihiro Tanaka, Masatoshi Komura, Mitsuaki Isobe, Tetsushi Furukawa. Common genetic variants indicate the risk of atrial fibrillation in Japanese population.. The 63th Annual Meeting of the Japanese Heart Rhythm Society 2016.07.16 Sapporo

Tetsushi Furukawa. Add-on type cardiac development and arrhythmias. Annual Meeting of the Japanese Heart Rhythm Society 2016 July 15, 2016 2016.07.15 Sapporo, Hokkaido

Sasano T, Sugiyama K, Kurokawa J, Takahashi K, Okamura T, Kato N, Isobe M, Furukawa T. Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice. The 9th international conference on the biology, chemistry, and therapeutic approach of Nitric Oxide 2016.05.22

Furukawa T, Liu L, Ebana Y, Nitta J, Takahashi Y, Miyazaki M, Isobe M, Tanaka T . Gene-Guided Therapy in AF. Heart Rhythm Society's 37th Annual Scientific Sessions 2016.05.06 San Francisco

Hamada S, Hasegawa Y, Nishimura T, Furukawa T, Isobe M, Hirao K, Sasano T. Novel dielectric blood coagulometry can evaluate factor Xa and thrombin activity individually. The 80th Annual Scientific Meeting of the Japanese Circulation Society 2016.03.20 Sendai

Hayashi Y, Nitta J, Iwasaki T, Lee K, Watanabe K, Hirao T, Kato N, Inamura Y, Suzuki M, Negi K, Satoh A, Yamato T, Matsumurea Y, Asakawa K, Ebana Y, Furukawa T, Gohya M, Hirao K, Isobe M. The occurrence of ectopy from pulmonary veins in atrial fibrillation in middle-aged women. The 80th Annual Scientific Meeting of the Japanese Circulation Society 2016.03.19 Sendai

Hayashi Y, Nitta J, Iwasaki T, Lee K, Watanabe K, Hirao T, Kato N, Inamura Y, Suzuki M, Negi K, Satoh A, Yamato T, Matsumurea Y, Asakawa K, Ebana Y, Furukawa T, Gohya M, Hirao K, Isobe M. The genotype of SNPs related whether ectopy is from pulmonary vein or others in atrial fibrillation. The 80th Annual Scientific Meeting of the Japanese Circulation Society 2016.03.19 Sendai

Ito S, Ebana Y, Furukawa T. Neurl, ubiquitin E3 ligase, contributes to the maintenance of sarcomere structure and the regulation of autophagy. The 80th Annual Scientific Meeting of the Japanese Circulation Society 2016.03.19 Sendai

Takahashi K, Sasano T, Sugiyama K, Isobe M, Furukawa T. Contribution of pannexin-1 to cardioprotection and arrhythmogenicity induced by ischemia/reperfusion injury. The 80th Annual Scientific Meeting of the Japanese Circulation Society 2016.03.18 Sendai

Takahashi K, Sasano T, Sugiyama K, Orui Y, Isobe M, Furukawa T. Contribution of pannexin-1 to cardioprotection and arrhythmogenicity induced by preconditioning against ischemia/reperfusion injury. The 80th Annual Scientific Meeting of the Japanese Circulation Society 2016.03.18 Sendai

1. Sasano T, Sugiyama K, Kurokawa J, Takahashi K, Okamura T, Kato N, Isobe M, Furukawa T. Genetic deletion of Nos1ap induced ventricular arrhythmia and impairment of cardiac function under oxidative stress condition. 5th International Conference of Cardiovascular Medicine 2016.03.05 Taichung, Taiwan

Furukawa T. iPS cells and arrhythmia mechanism. 2015 8th APHRS 2015.11.22 Melbourne

Sugiyama K, Sasano T, Furukawa T. Oxidative stress induced ventricular arrhythmia and impairment cardiac function in Nos1ap deleted mice. 2015 8th APHRS 2015.11.19

Kurokawa J, Okada J, Hayashi E, Ashihara T, Yoshinaga T, Sugiura S, Li M, Kanda Y, Sekino Y, Sawada K, Hisada T, Furukawa T. A multidisciplinary approach for evaluation of drug-induced QT prolongation using human induced pluripotent stem cell-derived cardiomyocytes. 59th Biophysical Society Annual Meeting 2015.02.07 Baltimore

Sato Y, Satoh A, Nitta J, Honda Y, Kuroda S, Sekigawa M, Kanoh M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Asakawa K, Ebana Y, Furukawa T, Hirao K, Isobe M. Impact of SNP on 1q24 (rsrs593479) in PRRX1 for the age at onset of atrial fibrillation. The 78th Annual Scientific Meeting of the Japanese Circulation Society 2014.03.22 Tokyo

Takahashi Y, Ebana Y, Hayashi T, Miwa N, Masumura M, Goto K, Sakakibara A, Itoh J, Ohmi T, Ohno M, Katoh R, Nozato T, Satoh Y, Furukawa T, Hirao K, Isobe M. Arrhythmogenicity of the superior vena cava and common single nucleotide polymorphisms in patients with paroxysmal atrial fibrillation. The 78th Annual Scientific Meeting of the Japanese Circulation Society 2014.03.22 Tokyo

Sato Y, Satoh A, Nitta J, Honda Y, Kuroda S, Sekigawa M, Kanoh M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Asakawa K, Ebana Y, Furukawa T, Hirao K, Isobe M. Impact of SNP on IL6R (rs7514452) for age at onset of atrial fibrillation. The 78th Annual Scientific Meeting of the Japanese Circulation Society 2014.03.22 Tokyo

Okata S, Yuasa S, Suzuki T, Egashira T, Kuroda Y, Tanaka A, Makita N, Kurokawa J, Furukawa T, Fukuda K. Na+ channel beta-subunit affects the phenotype in long QT syndrome type 3 and Brugada syndrome induced pluripotent stem cell-derived cardiomyocytes. The 78th Annual Scientific Meeting of the Japanese Circulation Society 2014.03.22 Tokyo

Sato A, Honda Y, Sato Y, Kuroda S, Kanoh M, Sekigawa M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Nitta J, Asakawa K, Ebana Y, Furukawa T. The relationship between the single nucleotide polymorphism rs2634073 and arrhythmogenic superior vena cava in the patients with atrial fibrillation. The 78th Annual Scientific Meeting of the Japanese Circulation Society 2014.03.22 Tokyo

Takahashi K, Sasano T, Koizumi A, Sugiyama K, Furukawa T, Isobe M. High-fat diet increases vulnerability to atrial arrhythmia by conduction disturbance via microRNA. The 78th Annual Scientific Meeting of the Japanese Circulation Society 2014.03.21 Tokyo

Furukawa T, Ebana Y, Nogami A, Nitta J, Kobayashi K, Mokura M, Takahashi Y, Hachiya H, Miyazaki S, Nakamura H, Hirao K, Isobe M, Ozaki K, Kubo M, Tanaka T. Genome-wide association study (GWAS) for a cardiac arrhythmia, atrial fibrillation. The 78th Annual Scientific Meeting of the Japanese Circulation Society 2014.03.21 Tokyo

Furukawa T. Sex hormones on ventricular electrophysiology. The 2014 Annual Scientific Meeting of Taiwan HRS 2014.03.08 Taipei

Hayakawa T, Kunihiro T, Ando T, Unno H, Kobayashi S, Matsui E, Yada H, Kanda Y, Kurokawa J, Furukawa T. Contractile behaviors of human-induced pluripotent stem cell-derived cardiomyocyte monolayers evaluated with an image-based analysis using motion vector prediction technique: A comparison with extracellular electrophysiology. 13th annual meeting of Safety Pharmacology Society 2013.09.16 Rotterdam, Netherlands

Kodama M, Goryoda S, Tomida T, Furukawa T, Kurokawa J. Localized cAMP signaling in the heart regarding a cross-talk with a non-genomic pathway of progesterone receptors. The 2ndHD Physiology International Symposium 2013.06.29 Tokyo

Min L, Kanda Y, Ashihara T, Sekino Y, Furukawa T, Kurokawa J. Functional optimization of commercially available human induced pluripotent stem cell-derived cardiomyocytes for evaluation of drug-induced QT prolongation. The 2ndHD Physiology International Symposium 2013.06.29 Tokyo

Ebana Y, Ozaki K, Isobe M, Tanaka T, Furukawa T. A SNP in 4p15.2 was Identified as a Novel Atrial Fibrillation Associated Locus Through the GWAS in Japanese Population. 第77回日本循環器学会総会 2013.03.17 横浜

Ebana Y, Ozaki K, Nitta J, Takahashi Y, Hirao K, Isobe M, Tanaka T, Furukawa T. During the transdifferentiation from mesenchyme to cardiomyocyte, atrial fibrillation associated locus 4q25 enhanced PITX2c expression to interact with its promoter. 第77回日本循環器学会総会 2013.03.15

Kurokawa J, Kodama M, Goryoda S, T Furukawa. Involvement of PDE2 in a localized regulation of the L-type Ca2+ channels by progesterone. 57th Biophysical Society Annual Meeting 2013.02.04 Philadelphia

Lopez-Redondo F, Kurokawa J, Nomura F, Kaneko T, Hamada T, Yasuda K, Furukawa T. A comparative electrophysiological study. 57th Biophysical Society Annual Meeting 2013.02.04 Philadelphia

Furukawa T, Okata S, Yuasa S, Suzuki T, Makita N, Kurokawa J, Egashira T, Yamakawa H, Seki T, Aizawa T, Hashimoto H, Kuroda Y, Tanaka A, Yae K, Murata M, Aiba T, Shimizu W, Horie M, Kodama I, Ogawa S, Fukuda K. Disease modeling using iPS cells. The 78th Annual Scientific Meeting of the Japanese Circulation Society Tokyo

Sato Y, Satoh A, Nitta J, Honda Y, Kuroda S, Sekigawa M, Kanoh M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Asakawa K, Ebana Y, Furukawa T, Hirao K, Isobe M. Impact of SNP on IL6R (rs7514452) for age at onset of atrial fibrillation. The 78th Annual Scientific Meeting of the Japanese Circulation Society Tokyo

Sekigawa M, Satoh A, Nitta J, Sato Y, Honda Y, Kuroda S, Kanoh M, Suzuki M, Inaba O, Muramatsu K, Yamato T, Matsumura Y, Asakawa K, Ebana Y, Furukawa T, Hirao K, Isobe M. Effect of SNP on 9q22 (rs6479562) on the progression from paroxysmal atrial fibrillation to persistent atrial fibrillation. The 78th Annual Scientific Meeting of the Japanese Circulation Society Tokyo