Ayako Arai. Chronic Active Epstein-Barr Virus Infection: The Elucidation of the Pathophysiology and the Development of Therapeutic Methods. Microorganisms. 2021.01; 9 (1): ( PubMed, DOI )

Ichiro Yonese, Chizuko Sakashita, Ken-Ichi Imadome, Tohru Kobayashi, Masahide Yamamoto, Akihisa Sawada, Yoshinori Ito, Noriko Fukuhara, Asao Hirose, Yusuke Takeda, Masanori Makita, Tomoyuki Endo, Shun-Ichi Kimura, Masataka Ishimura, Osamu Miura, Shouichi Ohga, Hiroshi Kimura, Shigeyoshi Fujiwara, Ayako Arai. Nationwide survey of systemic chronic active EBV infection in Japan in accordance with the new WHO classification. Blood Adv. 2020.07; 4 (13): 2918-2926. ( PubMed, DOI )

Misako Nagasaka, Makoto Yamagishi, Naoko Yagishita, Natsumi Araya, Seiichiro Kobayashi, Junya Makiyama, Miyuki Kubokawa, Junji Yamauchi, Daisuke Hasegawa, Ariella L G Coler-Reilly, Shuntaro Tsutsumi, Yu Uemura, Ayako Arai, Ayako Takata, Eisuke Inoue, Yasuhiro Hasegawa, Toshiki Watanabe, Yutaka Suzuki, Kaoru Uchimaru, Tomoo Sato, Yoshihisa Yamano. Mortality and risk of progression to adult T cell leukemia/lymphoma in HTLV-1-associated myelopathy/tropical spastic paraparesis. Proc Natl Acad Sci U S A. 2020.05; 117 (21): 11685-11691. ( PubMed, DOI )

Ayako Arai, Hiroshi Takase, Mayumi Yoshimori, Kouhei Yamamoto, Manabu Mochizuki, Osamu Miura. Gene expression profiling of primary vitreoretinal lymphoma. Cancer Sci. 2020.04; 111 (4): 1417-1421. ( PubMed, DOI )

Azuchi Masuda, Yasushi Isobe, Koichi Sugimoto, Mayumi Yoshimori, Ayako Arai, Norio Komatsu. Efficient recruitment of c-FLIP L to the death-inducing signaling complex leads to Fas resistance in natural killer-cell lymphoma. Cancer Sci. 2020.03; 111 (3): 807-816. ( PubMed, DOI )

Tomoka Ishida, Hiroshi Takase, Ayako Arai, Kyoko Ohno-Matsui. Multimodal imaging of secondary vitreoretinal lymphoma with optic neuritis and retinal vasculitis Am J Ophthalmol Case Rep. 2020; in press.

Takashi Nagaishi, Daiki Yamada, Kohei Suzuki, Ryosuke Fukuyo, Eiko Saito, Masayoshi Fukuda, Taro Watabe, Naoya Tsugawa, Kengo Takeuchi, Kouhei Yamamoto, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe. Indolent T cell lymphoproliferative disorder with villous atrophy in small intestine diagnosed by single-balloon enteroscopy. Clin J Gastroenterol. 2019.10; 12 (5): 434-440. ( PubMed, DOI )

Hiroyuki Takahashi, Hiroshi Takase, Ayako Arai, Manabu Mochizuki, Kyoko Ohno-Matsui. Bilateral granulomatous panuveitis in two patients with T-cell type of chronic active Epstein-Barr virus infection. BMC Ophthalmol. 2019.03; 19 (1): 83. ( PubMed, DOI )

Arai A.. Advances in the Study of Chronic Active Epstein-Barr Virus Infection: Clinical Features Under the 2016 WHO Classification and Mechanisms of Development Frontiers Pediatrics. 2019.02;

Arai A.. Chronic active Epstein–Barr virus infection: a bi-faceted disease with inflammatory and neoplastic elements Immunological Medicine. 2019.01;

Yonese I, Takase H, Yoshimori M, Onozawa E, Tsuzura A, Miki T, Mochizuki M, Miura O, Arai A. CD79B mutations in primary vitreoretinal lymphoma: Diagnostic and prognostic potential. European journal of haematology. 2018.11; ( PubMed, DOI )

Onozawa E, Shibayama H, Takada H, Imadome KI, Aoki S, Yoshimori M, Shimizu N, Fujiwara S, Koyama T, Miura O, Arai A. STAT3 is constitutively activated in chronic active Epstein-Barr virus infection and can be a therapeutic target. Oncotarget. 2018.07; 9 (57): 31077-31089. ( PubMed, DOI )

S Tokoro, T Namiki, K Miura, K Watanabe, A Arai, K Imadome, H Yokozeki. Chronic active Epstein-Barr virus infection with cutaneous lymphoproliferation: haemophagocytosis in the skin and haemophagocytic syndrome. J Eur Acad Dermatol Venereol. 2017.10; [Epub ahead of print] ( PubMed, DOI )

Akira Toriihara, Ayako Arai, Masashi Nakadate, Kouhei Yamamoto, Ken-Ichi Imadome, Osamu Miura, Ukihide Tateishi. FDG-PET/CT findings of chronic active Epstein-Barr virus infection. Leuk. Lymphoma. 2017.10; 1-4. ( PubMed, DOI )

Akira Toriihara, Reiko Nakajima, Ayako Arai, Masashi Nakadate, Koichiro Abe, Kazunori Kubota, Ukihide Tateishi. Pathogenesis and FDG-PET/CT findings of Epstein-Barr virus-related lymphoid neoplasms. Ann Nucl Med. 2017.07; 31 (6): 425-436. ( PubMed, DOI )

Ayano Imai, Hiroshi Takase, Ken-Ichi Imadome, Go Matsuda, Iichiro Ohnishi, Kouhei Yamamoto, Takumi Kudo, Yoji Tanaka, Taketoshi Maehara, Osamu Miura, Ayako Arai. Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis. Intern. Med.. 2017.05; 56 (11): 1409-1414. ( PubMed, DOI )

Yujin Sekinaka, Noriko Mitsuiki, Kohsuke Imai, Miharu Yabe, Hiromasa Yabe, Kanako Mitsui-Sekinaka, Kenichi Honma, Masatoshi Takagi, Ayako Arai, Kenichi Yoshida, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Hideki Muramatsu, Seiji Kojima, Asuka Hira, Minoru Takata, Osamu Ohara, Seishi Ogawa, Tomohiro Morio, Shigeaki Nonoyama. Common Variable Immunodeficiency Caused by FANC Mutations. J. Clin. Immunol.. 2017.05; ( PubMed, DOI )

Honami Takada, Ken-Ichi Imadome, Haruna Shibayama, Mayumi Yoshimori, Ludan Wang, Yasunori Saitoh, Shin Uota, Shoji Yamaoka, Takatoshi Koyama, Norio Shimizu, Kouhei Yamamoto, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai. EBV induces persistent NF-κB activation and contributes to survival of EBV-positive neoplastic T- or NK-cells. PLoS ONE. 2017.03; 12 (3): e0174136. ( PubMed, DOI )

Hiroki Akiyama, Hiroshi Takase, Fumito Kubo, Tohru Miki, Masahide Yamamoto, Makoto Tomita, Manabu Mochizuki, Osamu Miura, Ayako Arai. High-dose methotrexate following intravitreal methotrexate administration in preventing central nervous system involvement of primary intraocular lymphoma. Cancer Science. 2016.10; 107 (10): 1458-1464. ( PubMed, DOI )

Shunsuke Yui, Hiroki Yamaguchi, Ken-ichi Imadome, Ayako Arai, Mikiko Takahashi, Ryuji Ohashi, Hayato Tamai, Keiichi Moriya, Kazutaka Nakayama, Akira Shimizu, Koiti Inokuchi. Epstein-Barr Virus-positive T-cell Lymphoproliferative Disease Following Umbilical Cord Blood Transplantation for Acute Myeloid Leukemia. J Nippon Med Sch. 2016.02; 83 (1): 35-42. ( PubMed, DOI )

Arai A, Sakashita C, Hirose C, Imadome K, Yamamoto M, Jinta M, Fujiwara S, Tomita M, Shimizu N, Morio T, and Miura O.. Hematopoietic stem cell transplantation for adults with EBV-positive T- or NK-cell lymphoproliferative disorders: efficacy and predictive markers Bone Marrow Transplantation. 2016.02; ( DOI )

Kudo D, Ohashi K, Komeno K, Nakamura Y, Shinagawa A, Yoshida C, Katsura Y, Ota I, Kakihana K, Kobayashi T, Kawai N, Kato A, Arai A, Yamamoto K, Toyota S, Kumagai T, Ohwada A, Miki T, Hori M, Okoshi Y, Kojima H, and Sakamaki H. Efficacy and safety of bortezomib-containing induction chemotherapy for autologous stem cell transplantation-eligible Japanese multiple myeloma patients —A phase 2 multicenter trial— International Journal of Myeloma. 2015.12; 5 (3): 15-22.

Yoshimori M, Takada H, Imadome K, Kurata M, Yamamoto K, Koyama T, Shimizu N, Fujiwara S, Miura O, Arai A.. P-glycoprotein is expressed and causes resistance to chemotherapy in EBV-positive T-cell lymphoproliferative diseases. Cancer Medicine. 2015.10; 4 (10): 1494-1504. ( DOI )

Makoto Hirokawa, Kenichi Sawada, Naohito Fujisima, Masanao Teramura, Masami, Bessho, Kazuo Dan, Hisashi Tsurumi, Shinji Nakao, Akio Urabe, Shin Fujisawa, Yuji Yonemura, Fumio Kawano, Kazuo Oshimi, Koichi Sugimoto, Akira Matsuda, Masamitsu Karasawa, Ayako Arai, Norio Komatsu, Hideo Harigae, Mitsuhiro Omine, Keiya Ozawa, Mineo Kurokawa for the PRCA Collaborative Study Group.. Long-term outcome of patients with acquired chronic pure red cell aplasia following immunosuppressive therapy Br J Haematol. 2015.06; 169 (6): 879-886. ( DOI )

Jinta M, Imadome K, Komatsu H, Yoshimori M, Kurata M, Fujiwara S, Miura O, Arai A.. L-Asparaginase monotherapy for EBV-positive T/NK lymphoproliferative diseases: A pilot Study. Journal of Medical and Dental Sciences. 2015.03; 62 (1): 1-9. ( DOI )

Takaaki Hattori, Ayako Arai, Takanori Yokota, Ken-Ichi Imadome, Hiroyuki Tomimitsu, Osamu Miura, Hidehiro Mizusawa. Immune-mediated neuropathy with Epstein-Barr virus-positive T-cell lymphoproliferative disease. Intern. Med.. 2015.01; 54 (1): 69-73. ( PubMed, DOI )

Makoto Arai, Ayako Arai, Shun-ichiro Izumi. Postgraduate education of traditional Japanese (Kampo) medicine: a current survey on the training hospitals in Kanagawa prefecture. Tokai J. Exp. Clin. Med.. 2014.12; 39 (4): 186-192. ( PubMed )

Mayumi Yoshimori, Ken-Ichi Imadome, Honami Komatsu, Ludan Wang, Yasunori Saitoh, Shoji Yamaoka, Tetsuya Fukuda, Morito Kurata, Takatoshi Koyama, Norio Shimizu, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai. CD137 expression is induced by Epstein-Barr virus infection through LMP1 in T or NK cells and mediates survival promoting signals. PLoS ONE. 2014.11; 9 (11): e112564. ( PubMed, DOI )

Nakatani K, Imai K, Shigeno M, Sato H, Tezuka M, Okawa T, Mitsuiki N, Isoda T, Tomizawa D, Takagi M, Nagasawa M, Kajiwara M, Yamamoto M, Arai A, Miura O, Kamae C, Nakagawa N, Honma K, Nonoyama S, Mizutani S, Morio T.. Cord blood transplantation is associated with rapid B cell neogenesis compared with bone marrow transplantation. Bone Marrow Transplant.. 2014.09; 49 1155-1161. ( DOI )

K Nakatani, K Imai, M Shigeno, H Sato, M Tezuka, T Okawa, N Mitsuiki, T Isoda, D Tomizawa, M Takagi, M Nagasawa, M Kajiwara, M Yamamoto, A Arai, O Miura, C Kamae, N Nakagawa, K Honma, S Nonoyama, S Mizutani, T Morio. Cord blood transplantation is associated with rapid B-cell neogenesis compared with BM transplantation. Bone Marrow Transplant.. 2014.09; 49 (9): 1155-1161. ( PubMed, DOI )

Ludan Wang, Aiko Sato-Otsubo, Sunao Sugita, Hiroshi Takase, Manabu Mochizuki, Yoshihiko Usui, Hiroshi Goto, Takatoshi Koyama, Hiroki Akiyama, Osamu Miura, Seishi Ogawa, Ayako Arai. High-resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays. Cancer Sci.. 2014.05; 105 (5): 592-599. ( PubMed, DOI )

Fujiwara S, Kimura H, Imadome K, Arai A, Kodama, E, Morio T, Shimizu N, and Wakiguchi H. . Current research on chronic active Epstein-Barr virus infection in Japan. Pediatrics International. 2014.04; 56 159-166. ( DOI )

Ayako Arai, Takeshi Yamaguchi, Honami Komatsu, Ken-Ichi Imadome, Morito Kurata, Kaoru Nagata, Osamu Miura. Infectious mononucleosis accompanied by clonal proliferation of EBV-infected cells and infection of CD8-positive cells. Int. J. Hematol.. 2014.03; 99 (5): 671-675. ( PubMed, DOI )

Keiko Yagi, Kouhei Yamamoto, Shigeaki Umeda, Shinya Abe, Shiho Suzuki, Iichiroh Onishi, Susumu Kirimura, Masashi Fukayama, Ayako Arai, Masanobu Kitagawa, Morito Kurata. Expression of multidrug resistance 1 gene in B-cell lymphomas: association with follicular dendritic cells. Histopathology. 2013.02; 62 (3): 414-420. ( PubMed, DOI )

Ayako Arai, Ayako Nogami, Ken-Ichi Imadome, Morito Kurata, Naomi Murakami, Shigeyoshi Fujiwara, Osamu Miura. Sequential monitoring of serum IL-6, TNF-α, and IFN-γ levels in a CAEBV patient treated by plasma exchange and immunochemotherapy. Int. J. Hematol.. 2012.11; 96 (5): 669-673. ( PubMed, DOI )

Ayako Arai, Ken-ichi Imadome, Ludan Wang, Nan Wu, Tetsuya Kurosu, Atsushi Wake, Hisashi Yamamoto, Yasunori Ota, Masayoshi Harigai, Shigeyoshi Fujiwara, Osamu Miura. Recurrence of chronic active Epstein-Barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation. Intern. Med.. 2012.04; 51 (7): 777-782. ( PubMed )

Ken-ichi Imadome, Misako Yajima, Ayako Arai, Atsuko Nakazawa, Fuyuko Kawano, Sayumi Ichikawa, Norio Shimizu, Naoki Yamamoto, Tomohiro Morio, Shouichi Ohga, Hiroyuki Nakamura, Mamoru Ito, Osamu Miura, Jun Komano, Shigeyoshi Fujiwara. Novel mouse xenograft models reveal a critical role of CD4+ T cells in the proliferation of EBV-infected T and NK cells. PLoS Pathog.. 2011.10; 7 (10): e1002326. ( PubMed, DOI )

Ayako Arai, Ken-Ichi Imadome, Yuko Watanabe, Mayumi Yoshimori, Takatoshi Koyama, Takeharu Kawaguchi, Chiaki Nakaseko, Shigeyoshi Fujiwara, Osamu Miura. Clinical features of adult-onset chronic active Epstein-Barr virus infection: a retrospective analysis. Int. J. Hematol.. 2011.05; 93 (5): 602-609. ( PubMed, DOI )

Yasunori Nakagawa, Kenshi Suzuki, Takayuki Hirose, Takaaki Chou, Shin Fujisawa, Michiko Kida, Kensuke Usuki, Yoji Ishida, Shuichi Taniguchi, Yasuji Kouzai, Shigeru Tomoyasu, Koji Miyazaki, Masaaki Higashihara, Kiyoshi Ando, Sadao Aoki, Ayako Arai, Nobu Akiyama, Kiyohiko Hatake, Shinichiro Okamoto, Kazuo Dan, Kazuma Ohyashiki, Akio Urabe. Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases: a multi-institutional study. J. Infect. Chemother.. 2011.02; 17 (1): 58-67. ( PubMed, DOI )

Yuki Okuhashi, Mai Itoh, Ayako Arai, Nobuo Nara, Shuji Tohda. Gamma-secretase inhibitors induce erythroid differentiation in erythroid leukemia cell lines. Anticancer Res.. 2010.10; 30 (10): 4071-4074. ( PubMed )

Yusuke Nakauchi, Hiroshi Takase, Sunao Sugita, Manabu Mochizuki, Satoko Shibata, Yasuyoshi Ishiwata, Yuka Shibuya, Masato Yasuhara, Osamu Miura, Ayako Arai. Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement. Int. J. Hematol.. 2010.07; 92 (1): 179-185. ( PubMed, DOI )

Gaku Oshikawa, Tetsuya Kurosu, Ayako Arai, Naomi Murakami, Osamu Miura. Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation. Cancer Genet. Cytogenet.. 2010.05; 199 (1): 56-61. ( PubMed, DOI )

Nobuo Kuninaka, Morito Kurata, Kouhei Yamamoto, Shiho Suzuki, Shigeaki Umeda, Susumu Kirimura, Ayako Arai, Yasunori Nakagawa, Kenshi Suzuki, Masanobu Kitagawa. Expression of Toll-like receptor 9 in bone marrow cells of myelodysplastic syndromes is down-regulated during transformation to overt leukemia. Exp. Mol. Pathol.. 2010.04; 88 (2): 293-298. ( PubMed, DOI )

Ayako Arai, Ken-Ichi Imadome, Shigeyoshi Fujiwara, Osamu Miura. Autoimmune hemolytic anemia accompanied by reactivation of an Epstein-Barr virus infection with suppressed CTL response to EBV-infected cells in an elderly man. Intern. Med.. 2010.02; 49 (4): 325-329. ( PubMed )

Shihoko Wakabayashi, Ayako Arai, Gaku Oshikawa, Akihiro Araki, Mamoru Watanabe, Naoyuki Uchida, Shuichi Taniguchi, Osamu Miura. Extranodal NK/T cell lymphoma, nasal type, of the small intestine diagnosed by double-balloon endoscopy. Int. J. Hematol.. 2009.12; 90 (5): 605-610. ( PubMed, DOI )

Sunao Sugita, Hiroshi Takase, Yoshiharu Sugamoto, Ayako Arai, Osamu Miura, Manabu Mochizuki. Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid. Jpn. J. Ophthalmol.. 2009.05; 53 (3): 209-214. ( PubMed, DOI )

Makoto Hirokawa, Ken-ichi Sawada, Naohito Fujishima, Fumio Kawano, Akiro Kimura, Takashi Watanabe, Ayako Arai, Toshimitsu Matsui, Shinji Nakao, Akio Urabe, Mitsuhiro Omine, Keiya Ozawa. Acquired pure red cell aplasia associated with malignant lymphomas: a nationwide cohort study in Japan for the PRCA Collaborative Study Group. Am. J. Hematol.. 2009.03; 84 (3): 144-148. ( PubMed, DOI )

Mizuho Nonaka, Shin Uota, Yasunori Saitoh, Mayumi Takahashi, Haruyo Sugimoto, Tohti Amet, Ayako Arai, Osamu Miura, Naoki Yamamoto, Shoji Yamaoka. Role for protein geranylgeranylation in adult T-cell leukemia cell survival. Exp. Cell Res.. 2009.01; 315 (2): 141-150. ( PubMed, DOI )

Naohito Fujishima, Ken-ichi Sawada, Makoto Hirokawa, Kazuo Oshimi, Koichi Sugimoto, Akira Matsuda, Masanao Teramura, Masamitsu Karasawa, Ayako Arai, Yuji Yonemura, Shinji Nakao, Akio Urabe, Mitsuhiro Omine, Keiya Ozawa, . Long-term responses and outcomes following immunosuppressive therapy in large granular lymphocyte leukemia-associated pure red cell aplasia: a Nationwide Cohort Study in Japan for the PRCA Collaborative Study Group. Haematologica. 2008.10; 93 (10): 1555-1559. ( PubMed, DOI )

H Tamai, H Yamaguchi, S Takahashi, A Tojo, H Hamaguchi, T Kobayashi, H Akiyama, H Sakamaki, H Okumura, Si Nakao, A Arai, O Miura, K Tajika, K Inokuchi, K Dan. Treatment of adult AML with t(6;11)(q27;q23) by allogeneic hematopoietic SCT in the first CR. Bone Marrow Transplant.. 2008.10; 42 (8): 553-554. ( PubMed, DOI )

Hayato Tamai, Hiroki Yamaguchi, Hiroyuki Hamaguchi, Fumiharu Yagasaki, Masami Bessho, Takeshi Kobayashi, Hideki Akiyama, Hisashi Sakamaki, Satoshi Takahashi, Arinobu Tojo, Ken Ohmine, Keiya Ozawa, Hirokazu Okumura, Shinji Nakao, Ayako Arai, Osamu Miura, Shigeo Toyota, Seiji Gomi, Yoshiro Murai, Noriko Usui, Keisuke Miyazawa, Kazuma Ohyashiki, Naoto Takahashi, Kenichi Sawada, Atsushi Kato, Kazuo Oshimi, Koiti Inokuchi, Kazuo Dan. Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study. Int. J. Hematol.. 2008.03; 87 (2): 195-202. ( PubMed, DOI )

Ayako Arai, Weihua Yan, Shihoko Wakabayashi, Shin Hayashi, Johji Inazawa, Osamu Miura. Successful imatinib treatment of cardiac involvement of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia followed by severe hepatotoxicity. Int. J. Hematol.. 2007.10; 86 (3): 233-237. ( PubMed, DOI )

S Horibe, M Takagi, J Unno, M Nagasawa, T Morio, A Arai, O Miura, M Ohta, M Kitagawa, S Mizutani. DNA damage check points prevent leukemic transformation in myelodysplastic syndrome. Leukemia. 2007.10; 21 (10): 2195-2198. ( PubMed, DOI )

Ayako Arai, Asako Kitano, Etsuko Sawabe, Hirokazu Kanegane, Toshio Miyawaki, Osamu Miura. Relapsing Campylobacter coli bacteremia with reactive arthritis in a patient with X-linked agammaglobulinemia. Intern. Med.. 2007.05; 46 (9): 605-609. ( PubMed )

Weihua Yan, Ayako Arai, Mae Aoki, Hidenori Ichijo, Osamu Miura. ASK1 is activated by arsenic trioxide in leukemic cells through accumulation of reactive oxygen species and may play a negative role in induction of apoptosis. Biochem. Biophys. Res. Commun.. 2007.04; 355 (4): 1038-1044. ( PubMed, DOI )

Ayako Arai, Mae Aoki, Yan Weihua, Aishun Jin, Osamu Miura. CrkL plays a role in SDF-1-induced activation of the Raf-1/MEK/Erk pathway through Ras and Rac to mediate chemotactic signaling in hematopoietic cells. Cell. Signal.. 2006.12; 18 (12): 2162-2171. ( PubMed, DOI )

A Jin, T Kurosu, K Tsuji, D Mizuchi, A Arai, H Fujita, M Hattori, N Minato, O Miura. BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion. Oncogene. 2006.07; 25 (31): 4332-4340. ( PubMed, DOI )

Ken-Ichi Imadome, Norio Shimizu, Ayako Arai, Osamu Miura, Ken Watanabe, Hiroyuki Nakamura, Shigeaki Nonoyama, Kohtaro Yamamoto, Shigeyoshi Fujiwara. Coexpression of CD40 and CD40 ligand in Epstein-Barr virus-infected T and NK cells and their role in cell survival. J. Infect. Dis.. 2005.10; 192 (8): 1340-1348. ( PubMed, DOI )

Ayako Arai, Asako Kitano, Tetsuya Kurosu, Koh Yamamoto, Tohru Miki, Naomi Murakami, Osamu Miura. Fluid retention during arsenic trioxide treatment in acute promyelocytic leukemia. Am. J. Hematol.. 2005.07; 79 (3): 247-248. ( PubMed, DOI )

Ayako Arai, Aishun Jin, Weihua Yan, Daisuke Mizuchi, Koh Yamamoto, Toshihiro Nanki, Osamu Miura. SDF-1 synergistically enhances IL-3-induced activation of the Raf-1/MEK/Erk signaling pathway through activation of Rac and its effector Pak kinases to promote hematopoiesis and chemotaxis. Cell. Signal.. 2005.04; 17 (4): 497-506. ( PubMed, DOI )

Zhen-Hua Jin, Tetsuya Kurosu, Mitsuko Yamaguchi, Ayako Arai, Osamu Miura. Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis. Oncogene. 2005.03; 24 (12): 1973-1981. ( PubMed, DOI )

Daisuke Mizuchi, Tetsuya Kurosu, Aiko Kida, Zhen-Hua Jin, Aishun Jin, Ayako Arai, Osamu Miura. BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells. Biochem. Biophys. Res. Commun.. 2005.01; 326 (3): 645-651. ( PubMed, DOI )

Eiichiro Kanda, Zhen-Hua Jin, Daisuke Mizuchi, Ayako Arai, Osamu Miura. Activation of Rac and tyrosine phosphorylation of cytokine receptors induced by cross-linking of integrin alpha4beta1 and cell adhesion in hematopoietic cells. Biochem. Biophys. Res. Commun.. 2003.02; 301 (4): 934-940. ( PubMed )

Ayako Arai, Eiichiro Kanda, Osamu Miura. Rac is activated by erythropoietin or interleukin-3 and is involved in activation of the Erk signaling pathway. Oncogene. 2002.04; 21 (17): 2641-2651. ( PubMed, DOI )

A Arai, E Kanda, Y Nosaka, N Miyasaka, O Miura. CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. J. Biol. Chem.. 2001.08; 276 (35): 33282-33290. ( PubMed, DOI )

Y Nosaka, A Arai, E Kanda, T Akasaki, H Sumimoto, N Miyasaka, O Miura. Rac is activated by tumor necrosis factor alpha and is involved in activation of Erk. Biochem. Biophys. Res. Commun.. 2001.07; 285 (3): 675-679. ( PubMed, DOI )

A Arai, Y Nosaka, E Kanda, K Yamamoto, N Miyasaka, O Miura. Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion. J. Biol. Chem.. 2001.03; 276 (13): 10453-10462. ( PubMed, DOI )

Y Nosaka, A Arai, N Miyasaka, O Miura. CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3. J. Biol. Chem.. 1999.10; 274 (42): 30154-30162. ( PubMed )

A Arai, Y Nosaka, H Kohsaka, N Miyasaka, O Miura. CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G. Blood. 1999.06; 93 (11): 3713-3722. ( PubMed )

H Chin, A Arai, H Wakao, R Kamiyama, N Miyasaka, O Miura. Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. Blood. 1998.05; 91 (10): 3734-3745. ( PubMed )

K Yamamoto, H Kobayashi, A Arai, O Miura, S Hirosawa, N Miyasaka. cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3. Cytogenet. Cell Genet.. 1997.12; 77 (3-4): 207-210. ( PubMed )

H Chin, T Saito, A Arai, K Yamamoto, R Kamiyama, N Miyasaka, O Miura. Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells. Biochem. Biophys. Res. Commun.. 1997.10; 239 (2): 412-417. ( PubMed, DOI )

T Miki, N Kawamata, A Arai, K Ohashi, Y Nakamura, A Kato, S Hirosawa, N Aoki. Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias. Blood. 1994.01; 83 (1): 217-222. ( PubMed )

新井文子、細井広子、氏家一知、桃井優、松田正樹、末永松彦、田中耕、星野正信. 維持透析中に肝膿瘍を合併した１例 日本透析療法学会雑誌. 1993.05; 26 (5): 685-688.

Arai A, Yonese I, Sakashita C, Imadome KI, Kobayashi T, Sawada A, Itoh Y, Ohga S, Kimura H, Fujiwara S. Nationwide survey of chemotherapy for CAEBV in Japan. The 59th American Society of Hematology Annual Meeting & Exposition 2018.12.01 San Diego

Arai A, Yonese I, Sakashita C, Imadome KI, Kobayashi T, Sawada A, Itoh Y, Ohga S, Kimura H, Fujiwara S. Nationwide survey of chemotherapy for CAEBV in Japan. 2018 International Conference on EBV and KSHV 2018.07.29 Madison, U.S.A

Akiho Tsuzura, Mayumi Yoshimori,Kanoko Konno, Ken-Ichi Imadome, Erika Onozawa, Ryunosuke Ohkawa, Minoru Tozuka, Osamu Miura, Ayako Arai. Tumor Cells from EBV-Positive T- or NK-Cell Neoplasms Induce Differentiation and Activation of Macrophages by Secreting Humoral Factors. The 59th American Society of Hematology Annual Meeting 2017.12.11 Atlanta

Tomoko Yamashita, Hiroki Tsutsumi, Kota Yoshifuji, Tatsuya Saito, Yoshihiro Umezawa, Ayako Nogami, Ken Watanabe, Toshikage Nagao, Chizduko Sakashita, Masahide Yamamoto, Ayako Arai, Norihiko Kawamata, Osamu Miura, Tetsuya Fukuda. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with 11q Deletion. 第79回日本血液学会学術集会 2017.10.22

Erika Onozawa, Haruna Shibayama, Sho Aoki, Akiho Tuzura, Ken-ich Imadome, Takatoshi Koyama, Osamu Miura, Ayako Arai. STAT3 is constitutively activated and can be a therapeutic target of JAK inhibitors in chronic active Epstein-Barr virus infection. The 22th Congress of European society of Hematology 2017.06.23 Madrid

Haruna Shibayama, Ken-ichi Imadome, Chizuko Sakashita, Ken Watanabe, Fuyuko Kawano, Norio Shimizu, Takatoshi Koyama, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai. In vitro and in vivo effects of bortezomib on EBV-T/NK-LPDs. The 78th Annual Meeting of the Japanese Society of Hematology 2016.10.14 Yokohama

Yujin Sekinaka, Noriko Mitsuiki, Kohsuke Imai, Miharu Yabe, Hiromasa Yabe, Masatoshi Takagi, Ayako Arai, Kenichi Yoshida, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seiji Kojima, Asuka Hira, Minoru Takata, Osamu Ohara, Seishi Ogawa, Tomohiro Morio, and Shigeaki Nonoyama.. Common variable immunodeficiency caused by FANC mutations.. 17th Biennial Meeting of European Society for Immunodeficiencie. 2016.09 Barcelona

Haruna Shibayama, Ken-ichi Imadome, Chizuko Sakashita, Ken Watanabe, Norio Shimizu, Takatoshi Koyama, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai. In vitro and in vivo effects of proteasome inhibitor bortezomib on Epstein-Barr virus-positive T- or NK-cell lymphoproliferative diseases. 17th International Symposium on Epstein-Barr virus (EBV) and Associated Diseases 2016.08.10 Zurich

鈴木　さやか,田中　圭祐,迎　純一,渡邉　健,坂下　千瑞子,押川　学,山本　正英,福田　哲也,新井　文子,三浦　修. 染色体異常i(X)(p10)を伴う非定型慢性骨髄性白血病. 第4回日本血液学会関東甲信越地方会 2016.03.19 東京

Ayako Arai, Hiroshi Takase, Kouhei Yamamoto, Hiroki Akiyama, Manabu Mochizuki, Osamu Miura. Gene expression profiling of primary vitreoretinal lymphoma. 57th ASH Annual Meeting and Exposition 2015.12.05 Orlando

Akira Toriihara, Reiko Nakajima, Ayako Arai, Masashi Nakadate, Koichiro Abe, Kazunori Kubota, Ukihide Tateishi. FDG-PET/CT of Epstein-Barr virus-related lymphoproliferative disorders: knowledge for rapid and appropriate diagnosis.. 102nd Scientific Assembly and Annual Meeting of Radiological Society of North America 2015.11.29 Chicago

渡邉健　他. Short chemotherapy prior to 90Y-ibritumomab tiuxetan for relapsed FL in a single institution.. 第77回日本血液学会学術集会 2015.10.18 石川県金沢市

Emi Uchida, Shunichirou Yasuda, Ken Watanabe, Gaku Oshikawa, Masahide Yamamoto, Tetsuya Kurosu, Ayako Arai, Osamu Miura, Tetsuya Fukuda. A retrospective analysis of CLL treated with the FCR regimen.. 第77回日本血液学会学術集会 2015.10

Makoto Arai, Ayako Arai, Shun-ichiro Izumi. Postgraduate education in Kampo (traditional Japanese) medicine: A current survey of clinical training hospitals. An International Association of Medical Education (AMEE) 2015.09.08 Glasgow

Komatsu H, Imadome K, Shibayama H. Yada T, Yamada M, Yamamoto K, Koyama T, Fujiwara S, Miura O, Arai A. STAT3 is activated by EBV in T or NK cells leading to development of EBV-T/NK-lymphoproliferative disorders. 56th ASH Annual Meeting and Exposition 2014.12.06 San Francisco

Hiroki Akiyama, Hiroshi Takase, Fumito Kubo, Tohru Miki, Masahidde Yamamoto, Makoto Tomita, Manabu Mochizuki, Osamu Miura, Ayako Arai . Systemic following intravitreal MTX administration prevents CNS infiltration of Primary intraocular lymphoma. 56th ASH Annual Meeting and Exposition 2014.12 San Francisco

Toriihara A, Arai A, Kubota K, Makino T, Shibuya H. FDG-PET/CT findings of adult-onset Epstein-Barr virus positive T- or NK-cell lymphoproliferative disease. Annual meeting of Radiological Society of North America 2014.11.30 Chicago

Makoto Arai, Ayako Arai, Shun-ichiro Izumi. Postgraduate education in Kampo (traditional Japanese) medicine: A current survey of clinical training hospitals. The Association for Medical Education in Europe 2014.09 Milan

Ken-Ichi Imadome1, Go Matsuda1, Fuyuko Kawano1, Eiichi Kodama2, Ayako Arai3, Norio Shimizu4, and Shigeyoshi Fujiwara. Applications of mouse models of EBV-associated diseases for the evaluation of novel therapies. 16th International Symposium on EBV and Associated Diseases 2014.08 Brisbane

Ken-Ichi Imadome1, Go Matsuda1, Fuyuko Kawano1, Eiichi Kodama2, Ayako Arai3, Norio Shimizu4, and Shigeyoshi Fujiwara1. Preclinical studies of novel therapies for Epstein-Barr virus-associated diseases in humanized mouse models. 39th Annual International Herpesvirus Workshop (IHW) 2014.07 Kobe