Personnel Information

写真a

MIKI Yoshio


Job title

Visiting Lecturer

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JAPAN

Mail Address

The inquiry by e-mail is 《here

Homepage URL

http://www.tmd.ac.jp/mri/mgen/index_j.html

Research Areas, Keywords

Carcinogenesis, Breast Cancer, Genome Medicine, Hereditary Cancer, Genome Stability Research

Graduating School 【 display / non-display

  • Wakayama Medical University, Faculty of Medicine, 1981.03, Graduated

Graduate School 【 display / non-display

  • Hyogo College of Medicine, Graduate School, Division of Medicine, Doctor's Course, Completed

Campus Career 【 display / non-display

  • 2002.04
    -
    2022.03
    Tokyo Medical and Dental University, Medical Research Institute, Medical Genomics, Molecular Genetics, Professor
  • 2002.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Applied Gene Medicine, Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Public Health, Life Sciences and Bioethics, Visiting Lecturer

External Career 【 display / non-display

  • , Trainee Resident

Academic Society Affiliations 【 display / non-display

  • Japanese Organization of Hereditary Breast and Ovarian Cancer(JOHBOC)

Research Areas 【 display / non-display

  • Tumor biology

  • Pathological biochemistry

  • Medical biochemistry

  • Genome biology

Qualification Acquired 【 display / non-display

  • Doctor

 

Research Theme 【 display / non-display

  • Molecular Mechanisms of Breast Cancer Progression

  • Cancer Genome Research

  • Cell Death Signaling in Cancer

  • DNA Damage Repair and Genome Instability in Cancer

  • Hormone-Dependent Breast Cancer Cell Growth

  • Cancer Microenvironment

▼display all

Published Papers & Misc 【 display / non-display

  1. Inazawa J, Miki Y, Nakamura Y. Integrative cancer genomics in the era of precision cancer medicine. Journal of human genetics. 2021.09; 66 (9): 843. ( PubMed, DOI )

  2. Sunada S, Saito H, Zhang D, Xu Z, Miki Y. CDK1 inhibitor controls G2/M phase transition and reverses DNA damage sensitivity. Biochemical and biophysical research communications. 2021.04; 550 56-61. ( PubMed, DOI )

  3. Enkhbat Gerelmaa, Uetake Hiroyuke, Nakanishi Akira, Miki Yoshio. Elucidation of the regulation mechanism of BRCA2 protein level in cell cycle CANCER SCIENCE. 2021.02; 112 653.

  4. Deng Yu, Otsuka Nao, Nakanishi Akira, Miki Yoshio. The role of BRCA2 in H3K4 methylation mediated by MLL CANCER SCIENCE. 2021.02; 112 676.

  5. Tojo Yo, Nakanishi Akira, Miki Yoshio. The physiological role of centrosome pairs during S phase CANCER SCIENCE. 2021.02; 112 306.

  6. Miki Yoshio, Sunada Shigeaki, Nakanishi Akira. Targeting DNA repair pathways for new cancer treatment CANCER SCIENCE. 2021.02; 112 157.

  7. Miki Yoshio, Sugimura Haruhiko. Hereditary Cancer Research -Recent Updates and Future Directions CANCER SCIENCE. 2021.02; 112 1068.

  8. Yoshida R, Hagio T, Kaneyasu T, Gotoh O, Osako T, Tanaka N, Amino S, Yaguchi N, Nakashima E, Kitagawa D, Ueno T, Ohno S, Nakajima T, Nakamura S, Miki Y, Hirota T, Takahashi S, Matsuura M, Noda T, Mori S. Pathogenicity Assessment of Variants for Breast Cancer Susceptibility Genes Based on BRCAness of Tumor Sample. Cancer science. 2021.01; ( PubMed, DOI )

  9. Chin YM, Takahashi Y, Chan HT, Otaki M, Fujishima M, Shibayama T, Miki Y, Ueno T, Nakamura Y, Low SK. Ultradeep targeted sequencing of circulating tumor DNA in plasma of early and advanced breast cancer. Cancer science. 2020.10; 112 (1): 454-464. ( PubMed, DOI )

  10. Gao Y, Nihira NT, Bu X, Chu C, Zhang J, Kolodziejczyk A, Fan Y, Chan NT, Ma L, Liu J, Wang D, Dai X, Liu H, Ono M, Nakanishi A, Inuzuka H, North BJ, Huang YH, Sharma S, Geng Y, Xu W, Liu XS, Li L, Miki Y, Sicinski P, Freeman GJ, Wei W. Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nature cell biology. 2020.09; 22 (9): 1064-1075. ( PubMed, DOI )

  11. Ishiba Tohiyuki, Aruga Tomoyuki, Nara Miyako, Yabe Sakiko, Saita Chiaki, Onishi Mai, Iwamoto Naoko, Yonekura Rika, Miyamoto Hiromi, Honda Yayoi, Oda Goshi, Nakagawa Tsuyoshi, Nakanishi Akira, Uetake Hiroyuki, Miki Yoshio. Calretinin can be the specific marker for phyllodes tumor CANCER RESEARCH. 2020.08; 80 (16): ( DOI )

  12. Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T, Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nature genetics. 2020.07; 52 (7): 669-679. ( PubMed, DOI )

  13. Deng Y, Miki Y, Nakanishi A. Estradiol/GPER affects the integrity of mammary duct-like structures in vitro. Scientific reports. 2020.01; 10 (1): 1386. ( PubMed, DOI )

  14. Kaneyasu T, Mori S, Yamauchi H, Ohsumi S, Ohno S, Aoki D, Baba S, Kawano J, Miki Y, Matsumoto N, Nagasaki M, Yoshida R, Akashi-Tanaka S, Iwase T, Kitagawa D, Masuda K, Hirasawa A, Arai M, Takei J, Ide Y, Gotoh O, Yaguchi N, Nishi M, Kaneko K, Matsuyama Y, Okawa M, Suzuki M, Nezu A, Yokoyama S, Amino S, Inuzuka M, Noda T, Nakamura S. Prevalence of disease-causing genes in Japanese patients with <i>BRCA1/2</i>-wildtype hereditary breast and ovarian cancer syndrome. NPJ breast cancer. 2020; 6 25. ( PubMed, DOI )

  15. Low SK, Chin YM, Ito H, Matsuo K, Tanikawa C, Matsuda K, Saito H, Sakurai-Yageta M, Nakaya N, Shimizu A, Nishizuka SS, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Takezaki T, Suzuki S, Naito M, Wakai K, Kamatani Y, Momozawa Y, Murakami Y, Inazawa J, Nakamura Y, Kubo M, Katagiri T, Miki Y. Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population. Scientific reports. 2019.11; 9 (1): 17332. ( PubMed, DOI )

  16. Osumi H, Shinozaki E, Wakatsuki T, Suenaga M, Ichimura T, Ogura M, Takahari D, Ooki A, Suzuki T, Ota Y, Nakayama I, Chin K, Miki Y, Yamaguchi K. Non-V600E BRAF mutations and EGFR signaling pathway in colorectal cancer. International journal of cancer. 2019.04; ( PubMed, DOI )

  17. Miki Yoshio, Tomita Naohiro. An update on hereditary tumors CANCER SCIENCE. 2018.12; 109 777.

  18. Sunada Shigeaki, Miki Yoshio. DNA-PK inhibition releases PARP inhibitor-induced DNA replication stress CANCER SCIENCE. 2018.12; 109 833.

  19. Tojo Yo, Sato Ami, Saito Hiroko, Nakanishi Akira, Miki Yoshio. Analysis of the function of estrogen-mediated BRCA2 CANCER SCIENCE. 2018.12; 109 1136.

  20. Deng Yu, Nakanishi Akira, Miki Yoshio. Analysis of disruption mechanism of the breast duct and basement membrane by estradiol CANCER SCIENCE. 2018.12; 109 1161.

  21. Momozawa Y, Iwasaki Y, Parsons MT, Kamatani Y, Takahashi A, Tamura C, Katagiri T, Yoshida T, Nakamura S, Sugano K, Miki Y, Hirata M, Matsuda K, Spurdle AB, Kubo M. Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls. Nature communications. 2018.10; 9 (1): 4083. ( PubMed, DOI )

  22. Egi Moritoki, Kataoka Jun, Ito Takashi, Nishida Osamu, Yasuda Hideto, Okamaoto Hiroshi, Shimoyama Akira, Izawa Masayo, Matsumoto Shinsaku, Furushima Nana, Yamashita Shigeki, Takada Koji, Ohtsuka Masahide, Fujisaki Noritomo, Shime Nobuaki, Inagaki Nobuhiro, Taira Yasuhiko, Yatabe Tomoaki, Nitta Kenichi, Yokoyama Takeshi, Kushimoto Shigeki, Tokunaga Kentaro, Doi Matsuyuki, Masuda Takahiro, Miki Yasuo, Matsuda Kenichi, Asaga Takehiko, Hazama Keita, Matsuyama Hiroki, Nishimura Masaji, Mizobuchi Satoshi. Oxygen management in mechanically ventilated patients: A multicenter prospective observational study JOURNAL OF CRITICAL CARE. 2018.08; 46 1-5. ( DOI )

  23. Hiroki Osumi, Eiji Shinozaki, Tetsuo Mashima, Takeru Wakatsuki, Mitsukuni Suenaga, Takashi Ichimura, Mariko Ogura, Yumiko Ota, Izuma Nakayama, Daisuke Takahari, Keisho Chin, Yoshio Miki, Kensei Yamaguchi. Phase II trial of biweekly cetuximab and irinotecan as third-line therapy for pretreated KRAS exon 2 wild-type colorectal cancer. Cancer Sci.. 2018.06; ( PubMed, DOI )

  24. Shigeaki Sunada, Akira Nakanishi, Yoshio Miki. Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer. Cancer Sci.. 2018.04; 109 (4): 893-899. ( PubMed, DOI )

  25. Miho Takaoka, Yoshio Miki. BRCA1 gene: function and deficiency. Int. J. Clin. Oncol.. 2018.02; 23 (1): 36-44. ( PubMed, DOI )

  26. Takaoka Miho, Miki Yoshio. BRCA1遺伝子 機能および欠損(BRCA1 gene: function and deficiency) International Journal of Clinical Oncology. 2018.02; 23 (1): 36-44. ( ichushi )

  27. Takahashi Yasuko, Matsushita Yosuke, Komatsu Masato, Yoshimaru Tetsuro, Honda Junko, Osumi Syozo, Miki Yoshio, Imoto Issei, Miyoshi Yasuo, Sasa Mitsunori, Katagiri Toyomasa. Identification of novel susceptibility genes in Japanese hereditary breast cancer families by whole exome sequencing CANCER SCIENCE. 2018.01; 109 997.

  28. Takaoka Miho, Nakanishi Akira, Miki Yoshio. FKBP51 regulates cell motility and invasion via RhoA signaling CANCER SCIENCE. 2018.01; 109 866.

  29. Yamada Shota, Takaoka Miho, Nakanishi Akira, Miki Yoshio. Microtubule stabilization by the loss of BRCA2 is attributed to MAP4 assembly CANCER SCIENCE. 2018.01; 109 998.

  30. Katsutoshi Sato, Mio Koyasu, Sachio Nomura, Yuri Sato, Mizuho Kita, Yuumi Ashihara, Yasue Adachi, Shinji Ohno, Takuji Iwase, Dai Kitagawa, Eri Nakashima, Reiko Yoshida, Yoshio Miki, Masami Arai. Mutation status of RAD51C, PALB2 and BRIP1 in 100 Japanese familial breast cancer cases without BRCA1 and BRCA2 mutations. Cancer Sci.. 2017.11; 108 (11): 2287-2294. ( PubMed, DOI )

  31. Sato Katsutoshi, Koyasu Mio, Nomura Sachio, Sato Yuri, Kita Mizuho, Ashihara Yuumi, Adachi Yasue, Ohno Shinji, Iwase Takuji, Kitagawa Dai, Nakashima Eri, Yoshida Reiko, Miki Yoshio, Arai Masami. Mutation status of RAD51C, PALB2 and BRIP1 in 100 Japanese familial breast cancer cases without BRCA1 and BRCA2 mutations Cancer Science. 2017.11; 108 (11): 2287-2294. ( ichushi )

  32. Kazuhisa Hosoya, Satoshi Matsusaka, Tomomi Kashiwada, Koichi Suzuki, Norio Ureshino, Akemi Sato, Yoshio Miki, Kazuki Kitera, Mitsuharu Hirai, Kiyohiko Hatake, Shinya Kimura, Naoko Sueoka-Aragane. Detection of KRAS Mutations in Plasma DNA Using a fully Automated Rapid Detection System in Colorectal Cancer Patients. Pathol. Oncol. Res.. 2017.10; 23 (4): 737-744. ( PubMed, DOI )

  33. 中村 清吾, 藤原 康弘,三木 義男. がんゲノム医療 臨床における課題と将来展望 カレントテラピー. 2017.09; 35 (9): 894-901.

  34. Koshi Nakamura, Emiko Okada, Shigekazu Ukawa, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Yutaka Kiyohara, Kaori Muto, Yoichiro Kamatani, Toshiharu Ninomiya, Koichi Matsuda, Michiaki Kubo, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Rai Shimoyama, Koichi Maekawa, Kiyoshi Kaneko, Hiromasa Harada, Shiro Minami, Hiroyuki Takei, Mitsue Saito, Yasuhisa Terao, Satoru Takeda, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Hajime Abe, Tomoharu Shimizu, Yukihiro Koretsune, Norikazu Masuda, Yasutaka Takeda), Akiko Tamakoshi. Characteristics and prognosis of Japanese female breast cancer patients: The BioBank Japan project. J Epidemiol. 2017.03; 27 (3S): S58-S64. ( PubMed, DOI )

  35. Chi Thi Kim Nguyen, Takeshi Okamura, Kei-Ichi Morita, Satoshi Yamaguchi, Hiroyuki Harada, Yoshio Miki, Toshiyuki Izumo, Kou Kayamori, Akira Yamaguchi, Kei Sakamoto. LAMC2 is a predictive marker for the malignant progression of leukoplakia. J. Oral Pathol. Med.. 2017.03; 46 (3): 223-231. ( PubMed, DOI )

  36. Miho Takaoka, Shun Ito, Yoshio Miki, Akira Nakanishi. FKBP51 regulates cell motility and invasion via RhoA signaling. Cancer Sci.. 2017.03; 108 (3): 380-389. ( PubMed, DOI )

  37. Jun Hata, Akiko Nagai, Makoto Hirata, Yoichiro Kamatani, Akiko Tamakoshi, Zentaro Yamagata, Kaori Muto, Koichi Matsuda, Michiaki Kubo, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Shigeru Saito, Hideki Shimomura, Sinichi Higashiue, Kazuo Misumi, Shiro Minami, Masahiro Yasutake, Hitoshi Takano, Kazunori Shimada, Hakuoh Konishi, Nobukazu Miyamoto, SatoshiAsai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Yoshihisa Sugimoto, Takashi Ashihara, Yukihiro Koretsune, Sachiko Ikeda, Ryozo Yano), Yutaka Kiyohara, Toshiharu Ninomiya. Risk prediction models for mortality in patients with cardiovascular disease: The BioBank Japan project. J Epidemiol. 2017.03; 27 (3S): S71-S76. ( PubMed, DOI )

  38. Hiroshi Yokomichi, Akiko Nagai, Makoto Hirata, Yutaka Kiyohara, Kaori Muto, Toshiharu Ninomiya, Koichi Matsuda, Yoichiro Kamatani, Akiko Tamakoshi, Michiaki Kubo, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Sunao Matsubayashi, Hiromasa Harada, Kazuo Misumi, Rieko Komi, Shiro Minami, Hitoshi Sugihara, Naoya Emoto, Akio Kanazawa, Yusuke Suzuki, Yoshimune Hiratsuka, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Satoshi Ugi, Hiroshi Maegawa, Yukihiro Koretsune, Hideki Taki, Takeshi Osawa), Zentaro Yamagata. Serum glucose, cholesterol and blood pressure levels in Japanese type 1 and 2 diabetic patients: BioBank Japan. J Epidemiol. 2017.03; 27 (3S): S92-S97. ( PubMed, DOI )

  39. Akiko Nagai, Makoto Hirata, Yoichiro Kamatani, Kaori Muto, Koichi Matsuda, Yutaka Kiyohara, Toshiharu Ninomiya, Akiko Tamakoshi, Zentaro Yamagata, Taisei Mushiroda, Yoshinori Murakami, Koichiro Yuji, Yoichi Furukawa, Hitoshi Zembutsu, Toshihiro Tanaka, Yozo Ohnishi, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Masaki Shiono, Kazuo Misumi, Reiji Kaieda, Hiromasa Harada, Shiro Minami, Mitsuru Emi, Naoya Emoto, Hiroyuki Daida, Katsumi Miyauchi, Akira Murakami, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Hiromu Kutsumi, Yoshihisa Sugimoto, Yukihiro Koretsune, Hideo Kusuoka, Hideki Yanai), Michiaki Kubo. Overview of the BioBank Japan Project: Study design and profile. J Epidemiol. 2017.03; 27 (3S): S2-S8. ( PubMed, DOI )

  40. Makoto Hirata, Yoichiro Kamatani, Akiko Nagai, Yutaka Kiyohara, Toshiharu Ninomiya, Akiko Tamakoshi, Zentaro Yamagata, Michiaki Kubo, Kaori Muto, Taisei Mushiroda, Yoshinori Murakami, Koichiro Yuji, Yoichi Furukawa, Hitoshi Zembutsu, Toshihiro Tanaka, Yozo Ohnishi, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Masaki Shiono, Kazuo Misumi, Reiji Kaieda, Hiromasa Harada, Shiro Minami, Mitsuru Emi, Naoya Emoto, Hajime Arai, Ken Yamaji, Yoshimune Hiratsuka, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Hiromu Kutsumi, Yoshihisa Sugimoto, Yukihiro Koretsune, Hideo Kusuoka, Takashi Yoshiyama), Koichi Matsuda. Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases. J Epidemiol. 2017.03; 27 (3S): S9-S21. ( PubMed, DOI )

  41. Emiko Okada, Shigekazu Ukawa, Koshi Nakamura, Makoto Hirata, Akiko Nagai, Koichi Matsuda, Toshiharu Ninomiya, Yutaka Kiyohara, Kaori Muto, Yoichiro Kamatani, Zentaro Yamagata, Michiaki Kubo, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Rai Shimoyama, Shinichiro Makimoto, Hiromasa Harada, Tomoaki Fujikawa, Shiro Minami, Eiji Uchida, Masao Miyashita, Yoshiaki Kajiyama, Natsumi Tomita, Akihito Nagahara, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Hiromitsu Ban, Satoshi Murata, Yukihiro Koretsune, Motohiro Hirao, Hideo Ogata), Akiko Tamakoshi. Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer: The Biobank Japan Project. J Epidemiol. 2017.03; 27 (3S): S29-S35. ( PubMed, DOI )

  42. Makoto Hirata, Akiko Nagai, Yoichiro Kamatani, Toshiharu Ninomiya, Akiko Tamakoshi, Zentaro Yamagata, Michiaki Kubo, Kaori Muto, Yutaka Kiyohara, Taisei Mushiroda, Yoshinori Murakami, Koichiro Yuji, Yoichi Furukawa, Hitoshi Zembutsu, Toshihiro Tanaka, Yozo Ohnishi, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Masaki Shiono, Kazuo Misumi, Reiji Kaieda, Hiromasa Harada, Shiro Minami, Atsushi Watanabe, Naoya Emoto, Kazuhisa Takahashi, Satoru Takeda, Toshinari Funaki, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Hiromu Kutsumi, Yoshihisa Sugimoto, Yukihiro Koretsune, Hideo Kusuoka, Kozo Yoshimori), Koichi Matsuda. Overview of BioBank Japan follow-up data in 32 diseases. J Epidemiol. 2017.03; 27 (3S): S22-S28. ( PubMed, DOI )

  43. Hiroshi Yokomichi, Akiko Nagai, Makoto Hirata, Akiko Tamakoshi, Yutaka Kiyohara, Yoichiro Kamatani, Kaori Muto, Toshiharu Ninomiya, Koichi Matsuda, Michiaki Kubo, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Kazuo Misumi, Nobuyoshi Higa, Sunao Matsubayashi, Kei Matsuura, Shiro Minami, Hitoshi Sugihara, Naoya Emoto, Hirotoshi Ohmura, Akihiro Inui, Michihiro Ogasawara, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Satoshi Ugi, Hiroshi Maegawa, Yukihiro Koretsune, Hideo Kusuoka, Masako Ueyama), Zentaro Yamagata. Statin use and all-cause and cancer mortality: BioBank Japan cohort. J Epidemiol. 2017.03; 27 (3S): S84-S91. ( PubMed, DOI )

  44. Hiroshi Yokomichi, Hokuto Noda, Akiko Nagai, Makoto Hirata, Akiko Tamakoshi, Yoichiro Kamatani, Yutaka Kiyohara, Koichi Matsuda, Kaori Muto, Toshiharu Ninomiya, Michiaki Kubo, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Kazuo Misumi, Kiyoshi Iha, Sunao Matsubayashi, Kei Matsuura, Shiro Minami, Hitoshi Sugihara, Eitaro Kodani, Naoto Tamura, Masakazu Matsushita, Akihiko Gotoh, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, SeijiroMori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Satoshi Ugi, Hiroshi Maegawa, Yukihiro Koretsune, Hideo Kusuoka, Masao Okumura), Zentaro Yamagata. Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities: BioBank Japan. J Epidemiol. 2017.03; 27 (3S): S77-S83. ( PubMed, DOI )

  45. Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Toshiharu Ninomiya, Kaori Muto, Yutaka Kiyohara, Koichi Matsuda, Yoichiro Kamatani, Michiaki Kubo, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Hiromasa Harada, Makoto Hibino, Atsushi Okuyama, Nobuyasu Kano, Shiro Minami, Akihiko Genma, Jitsuo Usuda, Kenji Suzuki, Mitsuaki Sekiya, Satoru Takeda, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Noriaki Tezuka, Yasutaka Nakano, Yukihiro Koretsune, Mitsumasa Ogawara, Kazunari Yamana), Akiko Tamakoshi. Characteristics and prognosis of Japanese male and female lung cancer patients: The BioBank Japan Project. J Epidemiol. 2017.03; 27 (3S): S49-S57. ( PubMed, DOI )

  46. Hiroshi Yokomichi, Akiko Nagai, Makoto Hirata, Yutaka Kiyohara, Kaori Muto, Toshiharu Ninomiya, Koichi Matsuda, Yoichiro Kamatani, Akiko Tamakoshi, Michiaki Kubo, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Hiromasa Harada, Sunao Matsubayashi, Rieko Komi, Kazuo Misumi, Shiro Minami, Hitoshi Sugihara, Eitaro Kodani, Akio Kanazawa, Hiromasa Gotoh, Hidenori Haruna, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Satoshi Ugi, Shinichi Araki, Yukihiro Koretsune, Hideki Taki, Takayuki Nakagawa), Zentaro Yamagata. Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan cohort. J Epidemiol. 2017.03; 27 (3S): S98-S106. ( PubMed, DOI )

  47. Shigekazu Ukawa, Emiko Okada, Koshi Nakamura, Makoto Hirata, Akiko Nagai, Koichi Matsuda, Zentaro Yamagata, Yoichiro Kamatani, Toshiharu Ninomiya, Yutaka Kiyohara, Kaori Muto, Michiaki Kubo, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Hiromasa Harada, Kiyoshi Kaneko, Shuichi Matsumoto, Masaki Shiono, Shiro Minami, Hiroshi Yoshida, Nobuhiko Taniai, Sumio Watanabe, Noriko Fujiwara, Atsuyuki Yamataka, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito,Satoshi Nagayama and Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Shigeyuki Naka, Yoshihiro Endo, Yukihiro Koretsune, Eiji Mita, Kozo Morimoto), Akiko Tamakoshi. Characteristics of patients with liver cancer in the BioBank Japan project. J Epidemiol. 2017.03; 27 (3S): S43-S48. ( PubMed, DOI )

  48. Tamakoshi A, Nakamura K, Ukawa S, Okada E, Hirata M, Nagai A, Matsuda K, Kamatani Y, Muto K, Kiyohara Y, Yamagata Z, Ninomiya T, Kubo M, Nakamura Y, BioBank Japan Cooperative Hospital Group (Wataru Ono, Hiromasa Harada, Shunji Kawamoto, Nobuaki Shinozaki, Shiro Minami, Takeshi Yamada, Hideyuki Suzuki, Kazuhiro Sakamoto, Kazuo Kaneko, Shinichi Ohba, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Tomoharu Shimizu, Shigeyuki Naka, Yukihiro Koretsune, Mitsugu Sekimoto, Hiroyuki Kokuto). Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project. J Epidemiol. 2017.03; 27 (3S): S36-S42. ( PubMed, DOI )

  49. Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Kaori Muto, Koichi Matsuda, Toshiharu Ninomiya, Yutaka Kiyohara, Yoichiro Kamatani, Michiaki Kubo, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group (Ichiro Miura, Katsuhiko Takatama, Yoshiyuki Nabeshima, Kazuo Misumi, Shiro Minami, Yukihiro Kondo, Go Kimura, Shigeo Horie, Shinichi Ohba, Shigaku Ikeda, Satoshi Asai, Mitsuhiko Moriyama, Yasuo Takahashi, Tomoaki Fujioka, Wataru Obara, Seijiro Mori, Hideki Ito, Satoshi Nagayama, Yoshio Miki, Akihide Masumoto, Akira Yamada, Yasuko Nishizawa, Ken Kodama, Keisei Okamoto, Susumu Kageyama, Yukihiro Koretsune, Yuko Nishigaki, Tsutomu Yoshida), Akiko Tamakoshi. Clinical and histopathological characteristics of patients with prostate cancer in the BioBank Japan project. J Epidemiol. 2017.03; 27 (3S): S65-S70. ( PubMed, DOI )

  50. Rumana Khanom, Chi Thi Kim Nguyen, Kou Kayamori, Xin Zhao, Keiichi Morita, Yoshio Miki, Ken-Ichi Katsube, Akira Yamaguchi, Kei Sakamoto. Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth. PLoS ONE. 2016.08; 11 (8): e0161163. ( PubMed, DOI )

  51. Sadiya Malik, Hiroko Saito, Miho Takaoka, Yoshio Miki, Akira Nakanishi. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Cell Cycle. 2016.08; 15 (16): 2145-2156. ( PubMed, DOI )

  52. 青木 大輔, 冨田 尚裕, 中村 清吾, 三木 義男, 武藤 香織. 遺伝性腫瘍 本邦における診療基盤の確立を考える 日本医師会雑誌. 2016.07; 145 (4): 677-689.

  53. Hiroki Osumi, Eiji Shinozaki, Mitsukuni Suenaga, Satoshi Matsusaka, Tsuyoshi Konishi, Takashi Akiyoshi, Yoshiya Fujimoto, Satoshi Nagayama, Yosuke Fukunaga, Masashi Ueno, Yoshihiro Mise, Takeaki Ishizawa, Yosuke Inoue, Yu Takahashi, Akio Saiura, Hirohumi Uehara, Mingyon Mun, Sakae Okumura, Nobuyuki Mizunuma, Yoshio Miki, Toshiharu Yamaguchi. RAS mutation is a prognostic biomarker in colorectal cancer patients with metastasectomy. Int. J. Cancer. 2016.03; ( PubMed, DOI )

  54. Junhui Wang, Qianshan Ding, Hiroaki Fujimori, Akira Motegi, Yoshio Miki, Mitsuko Masutani. Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors. Oncotarget. 2016.02; 7 (7): 7701-7714. ( PubMed, DOI )

  55. Samir Kumar Pal, Chi Thi Kim Nguyen, Kei-Ichi Morita, Yoshio Miki, Kou Kayamori, Akira Yamaguchi, Kei Sakamoto. THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma. J. Oral Pathol. Med.. 2016.02; ( PubMed, DOI )

  56. Toshiyuki Ishiba, Makoto Nagahara, Tsuyoshi Nakagawa, Takanobu Sato, Toshiaki Ishikawa, Hiroyuki Uetake, Kenichi Sugihara, Yoshio Miki, Akira Nakanishi. Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion. Sci Rep. 2014.11; 4 7069. ( PubMed, DOI )

  57. Tan Tuan Zea, Miow Qing Hao, Miki Yoshio, Noda Tetsuo, Mori Seiichi, Huang Ruby Yun-Ju, Thiery Jean Paul. Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients. EMBO Mol Med. 2014.10; 6 (10): 1279-1293. ( PubMed, DOI )

  58. Kimura Hitomi, Miki Yoshio, Nakanishi Akira. Centrosomes at M phase act as a scaffold for the accumulation of intracellular ubiquitinated proteins. Cell Cycle. 2014.04; 13 (12): 1928-1937. ( PubMed, DOI )

  59. Takaoka Miho, Saito Hiroko, Takenaka Katsuya, Miki Yoshio, Nakanishi Akira. BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC. Cancer Res. 2014.03; 74 (5): 1518-1528. ( PubMed, DOI )

  60. Wada Yusaku, Matsuura Masaaki, Sugawara Minoru, Ushijima Masaru, Miyata Satoshi, Nagasaki Koichi, Noda Tetsuo, Miki Yoshio. Development of detection method for novel fusion gene using GeneChip exon array. J Clin Bioinforma. 2014.02; 4 (1): 3. ( PubMed, DOI )

  61. Wali Nadila, Hosokawa Kana, Malik Sadiya, Saito Hiroko, Miyaguchi Ken, Imajoh-Ohmi Shinobu, Miki Yoshio, Nakanishi Akira. Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP). Biochem Biophys Res Commun. 2014.01; 443 (4): 1148-1154. ( PubMed, DOI )

  62. Nakamura Seigo, Takahashi Masato, Tozaki Mitsuhiro, Nakayama Takahiro, Nomizu Tadashi, Miki Yoshio, Murakami Yoshie, Aoki Daisuke, Iwase Takuji, Nishimura Seiichiro, Yamauchi Hideko, Ohsumi Shozo, Baba Shinichi, Shimizu Tadao. Prevalence and differentiation of hereditary breast and ovarian cancers in Japan. Breast Cancer. 2013.11; ( PubMed, DOI )

  63. Low Siew-Kee, Takahashi Atsushi, Ashikawa Kyota, Inazawa Johji, Miki Yoshio, Kubo Michiaki, Nakamura Yusuke, Katagiri Toyomasa. Genome-wide association study of breast cancer in the Japanese population. PLoS One. 2013.10; 8 (10): e76463. ( PubMed, DOI )

  64. Mimoto Rei, Taira Naoe, Takahashi Hiroyuki, Yamaguchi Tomoko, Okabe Masataka, Uchida Ken, Miki Yoshio, Yoshida Kiyotsugu. DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail. Cancer Lett. 2013.10; 339 (2): 214-225. ( PubMed, DOI )

  65. Kawazu Masahito, Ueno Toshihide, Kontani Kenji, Ogita Yoshitaka, Ando Mizuo, Fukumura Kazutaka, Yamato Azusa, Soda Manabu, Takeuchi Kengo, Miki Yoshio, Yamaguchi Hiroyuki, Yasuda Takahiko, Naoe Tomoki, Yamashita Yoshihiro, Katada Toshiaki, Choi Young Lim, Mano Hiroyuki. Transforming mutations of RAC guanosine triphosphatases in human cancers. Proc Natl Acad Sci U S A. 2013.02; 110 (8): 3029-3034. ( PubMed, DOI )

  66. Elgazzar Seham, Zembutsu Hitoshi, Takahashi Atsushi, Kubo Michiaki, Aki Fuminori, Hirata Koichi, Takatsuka Yuichi, Okazaki Minoru, Ohsumi Shozo, Yamakawa Takashi, Sasa Mitsunori, Katagiri Toyomasa, Miki Yoshio, Nakamura Yusuke. A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese. J Hum Genet. 2012.12; 57 (12): 766-771. ( PubMed, DOI )

  67. Satoh Yukitoshi, Sugai Sachiko, Uehara Hirofumi, Mun Mingyon, Sakao Yukinori, Okumura Sakae, Nakagawa Ken, Ishikawa Yuichi, Miki Yoshio, Miyata Satoshi. Clinical impact of intraoperative detection of carcinoembryonic antigen mRNA in pleural lavage specimens from nonsmall cell lung cancer patients. Thorac Cardiovasc Surg. 2012.12; 60 (8): 533-540. ( PubMed, DOI )

  68. Suzuki Kazuho, Dashzeveg Nurmaa, Lu Zheng-Guang, Taira Naoe, Miki Yoshio, Yoshida Kiyotsugu. Programmed cell death 6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage. Cancer Sci. 2012.10; 103 (10): 1788-1794. ( PubMed, DOI )

  69. Khanom Rumana, Sakamoto Kei, Pal Samir Kumar, Shimada Yasuyuki, Morita Kei-ichi, Omura Ken, Miki Yoshio, Yamaguchi Akira. Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies. Histol Histopathol. 2012.07; 27 (7): 949-959. ( PubMed )

  70. Sakamoto Kei, Fujii Takuma, Kawachi Hiroshi, Miki Yoshio, Omura Ken, Morita Kei-ichi, Kayamori Kou, Katsube Ken-ichi, Yamaguchi Akira. Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest. 2012.05; 92 (5): 688-702. ( PubMed, DOI )

  71. Taira Naoe, Mimoto Rei, Kurata Morito, Yamaguchi Tomoko, Kitagawa Masanobu, Miki Yoshio, Yoshida Kiyotsugu. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. J Clin Invest. 2012.03; 122 (3): 859-872. ( PubMed, DOI )

  72. Wang Linghua, Tsutsumi Shuichi, Kawaguchi Tokuichi, Nagasaki Koichi, Tatsuno Kenji, Yamamoto Shogo, Sang Fei, Sonoda Kohtaro, Sugawara Minoru, Saiura Akio, Hirono Seiko, Yamaue Hiroki, Miki Yoshio, Isomura Minoru, Totoki Yasushi, Nagae Genta, Isagawa Takayuki, Ueda Hiroki, Murayama-Hosokawa Satsuki, Shibata Tatsuhiro, Sakamoto Hiromi, Kanai Yae, Kaneda Atsushi, Noda Tetsuo, Aburatani Hiroyuki. Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res. 2012.02; 22 (2): 208-219. ( PubMed, DOI )

  73. Iyevleva Aglaya G, Kuligina Ekatherina Sh, Mitiushkina Nathalia V, Togo Alexandr V, Miki Yoshio, Imyanitov Evgeny N. High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas. Breast Cancer Res Treat. 2012.02; 131 (3): 1049-1059. ( PubMed, DOI )

  74. Hew Hoi Chin, Liu Hanshao, Miki Yoshio, Yoshida Kiyotsugu. PKCdelta regulates Mdm2 independently of p53 in the apoptotic response to DNA damage. Mol Carcinog. 2011.09; 50 (9): 719-731. ( PubMed, DOI )

  75. Hew Hoi Chin, Liu Hanshao, Lu Zheng-Guang, Kimura Junko, Miki Yoshio, Yoshida Kiyotsugu. Identification of Evi-1 as a novel effector of PKCdelta in the apoptotic response to DNA damage. Biochim Biophys Acta. 2011.07; 1809 (7): 285-294. ( PubMed, DOI )

  76. Kimura Junko, Kudoh Takuya, Miki Yoshio, Yoshida Kiyotsugu. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage. Int J Cancer. 2011.04; 128 (7): 1524-1531. ( PubMed, DOI )

  77. Sakamoto Kei, Aragaki Tadanobu, Morita Kei-ichi, Kawachi Hiroshi, Kayamori Kou, Nakanishi Shoichi, Omura Ken, Miki Yoshio, Okada Norihiko, Katsube Ken-Ichi, Takizawa Toichiro, Yamaguchi Akira. Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis. Histopathology. 2011.03; 58 (4): 531-542. ( PubMed, DOI )

  78. Wang Hui-Feng, Takenaka Katsuya, Nakanishi Akira, Miki Yoshio. BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2. Cancer Res. 2011.01; 71 (1): 68-77. ( PubMed, DOI )

  79. Ito Yoshinori, Nagasaki Koichi, Miki Yoshio, Iwase Takuji, Akiyama Futoshi, Matsuura Masaaki, Horii Rie, Makita Masujiro, Tokudome Nahomi, Ushijima Masaru, Yoshimoto Masataka, Takahashi Shunji, Noda Tetsuo, Hatake Kiyohiko. Prospective randomized phase II study determines the clinical usefulness of genetic biomarkers for sensitivity to primary chemotherapy with paclitaxel in breast cancer. Cancer Sci. 2011.01; 102 (1): 130-136. ( PubMed, DOI )

  80. Kudoh Takuya, Kimura Junko, Lu Zheng-Guang, Miki Yoshio, Yoshida Kiyotsugu. D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage. Exp Cell Res. 2010.10; 316 (17): 2849-2858. ( PubMed, DOI )

  81. Yamaguchi Tomoko, Miki Yoshio, Yoshida Kiyotsugu. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage. Apoptosis. 2010.08; 15 (8): 927-935. ( PubMed, DOI )

  82. Yun Xia, Wang Lihong, Cao Lei, Okada Norihiko, Miki Yoshio. Immunohistochemical study of beta-catenin and functionally related molecular markers in tongue squamous cell carcinoma and its correlation with cellular proliferation. Oncol Lett. 2010.05; 1 (3): 437-443. ( PubMed, DOI )

  83. Miki Yoshio. Gene expression-based diagnosis of efficacy of chemotherapy for breast cancer. Breast Cancer. 2010.04; 17 (2): 97-102. ( PubMed, DOI )

  84. Yoshida Kiyotsugu, Miki Yoshio. The cell death machinery governed by the p53 tumor suppressor in response to DNA damage. Cancer Sci. 2010.04; 101 (4): 831-835. ( PubMed, DOI )

  85. Tanaka Shinji, Mogushi Kaoru, Yasen Mahmut, Noguchi Norio, Kudo Atsushi, Nakamura Noriaki, Ito Koji, Miki Yoshio, Inazawa Johji, Tanaka Hiroshi, Arii Shigeki. Gene-expression phenotypes for vascular invasiveness of hepatocellular carcinomas. Surgery. 2010.03; 147 (3): 405-414. ( PubMed, DOI )

  86. Ogi Tomoo, Limsirichaikul Siripan, Overmeer Rene M, Volker Marcel, Takenaka Katsuya, Cloney Ross, Nakazawa Yuka, Niimi Atsuko, Miki Yoshio, Jaspers Nicolaas G, Mullenders Leon H F, Yamashita Shunichi, Fousteri Maria I, Lehmann Alan R. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Mol Cell. 2010.03; 37 (5): 714-727. ( PubMed, DOI )

  87. Kayamori Kou, Sakamoto Kei, Nakashima Tomoki, Takayanagi Hiroshi, Morita Kei-Ichi, Omura Ken, Nguyen Su Tien, Miki Yoshio, Iimura Tadahiro, Himeno Akiko, Akashi Takumi, Yamada-Okabe Hisafumi, Ogata Etsuro, Yamaguchi Akira. Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells. Am J Pathol. 2010.02; 176 (2): 968-980. ( PubMed, DOI )

  88. Taira Naoe, Yamamoto Hiroyuki, Yamaguchi Tomoko, Miki Yoshio, Yoshida Kiyotsugu. ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. J Biol Chem. 2010.02; 285 (7): 4909-4919. ( PubMed, DOI )

  89. Hirono Seiko, Yamaue Hiroki, Hoshikawa Yutaka, Ina Shinomi, Tani Masaji, Kawai Manabu, Ushijima Masaru, Matsuura Masaaki, Saiki Yuriko, Saiura Akio, Yamamoto Junji, Miki Yoshio, Noda Tetsuo. Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling. Cancer Sci. 2010.01; 101 (1): 259-266. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Yoshida Reiko, Hagio Taichi, Kaneyasu Tomoko, Gotoh Osamu, Osako Tomo, Tanaka Norio, Amino Sayuri, Yaguchi Noriko, Nakashima Eri, Kitagawa Dai, Ueno Takayuki, Ohno Shinji, Nakajima Takeshi, Nakamura Seigo, Miki Yoshio, Hirota Toru, Takahashi Shunji, Matsuura Masaaki, Noda Tetsuo, Mori Seiichi. Pathogenicity assessment of variants for breast cancer susceptibility genes based on BRCAness of tumor sample(和訳中). Cancer Science 2021.03.01

  2. Chin Yoon Ming, Takahashi Yoko, Chan Hiu Ting, Otaki Masumi, Fujishima Makoto, Shibayama Tomoko, Miki Yoshio, Ueno Takayuki, Nakamura Yusuke, Low Siew-Kee. 早期および進行乳癌の血漿中の循環腫瘍DNAのウルトラディープ標的シーケンシング(Ultradeep targeted sequencing of circulating tumor DNA in plasma of early and advanced breast cancer). Cancer Science 2021.01.01

  3. 郭 倩倩, 徐 澤宇, 斉藤 広子, 砂田 成章, 三木 義男. 臨床的意義不明なBRCA2バリアントの相同組換え活性. 日本癌学会総会記事 2020.10.01

  4. Enkhbat Gerelmaa, Uetake Hiroyuke, 中西 啓, 三木 義男. 細胞周期におけるBRCA2タンパク質レベルの制御メカニズムの解明(Elucidation of the regulation mechanism of BRCA2 protein level in cell cycle). 日本癌学会総会記事 2020.10.01

  5. 三木 義男, 砂田 成章, 中西 啓. 乳がん微小環境の特性と全身性応答、新しい治療展開 遺伝子修復を標的とする新しい治療法の開発. 日本癌学会総会記事 2020.10.01

  6. 趙 ニン, 砂田 成章, 三木 義男. ステロイドホルモンはトポイソメラーゼ2機能不全に伴う毒性を増強する. 日本癌学会総会記事 2020.10.01

  7. 張 抖抖, 砂田 成章, 三木 義男. Tioxoloneによる新たな合成致死療法の開発. 日本癌学会総会記事 2020.10.01

  8. 東條 陽, 中西 啓, 三木 義男. S期中心体対の生理的役割. 日本癌学会総会記事 2020.10.01

  9. Deng Yu, 大塚 菜央, 中西 啓, 三木 義男. MLLを介したH3K4メチル化におけるBRCA2の役割. 日本癌学会総会記事 2020.10.01

  10. 三木 義男, 砂田 成章, 中西 啓. 遺伝子異常を標的とした乳癌の治療戦略 BRCA1/2変異 基礎から臨床へ. 日本癌治療学会学術集会抄録集 2020.10.01

  11. 張 抖抖, Zhao Ying, 砂田 成章, 三木 義男. 遺伝性乳がんにおけるPARP阻害剤耐性機構の獲得を克服する新たな合成致死療法の開発(Development of novel synthetic lethality for PARP inhibitor-resistant hereditary breast cancer). 日本放射線影響学会大会講演要旨集 2019.11.01

  12. XU ZEYU, GUO QIANQIAN, 斉藤 広子, 砂田 成章, 三木 義男. 遺伝性乳がん卵巣がんの原因遺伝子のVUSに対する相同組み換え活性に関する研究(Study on homologous recombination activities of VUSs in hereditary breast and ovarian cancer susceptibility genes). 日本癌学会総会記事 2019.09.01

  13. DENG YU, 中西 啓, 三木 義男. エストロゲンによる乳管及び基底膜崩壊機構の解析(Mechanism of breast duct and basement membrane disruption caused by estradiol). 日本癌学会総会記事 2019.09.01

  14. 東條 陽, 斉藤 広子, 中西 啓, 三木 義男. エストロゲン誘導性BRCA2の働き(Action of estrogen-mediated BRCA2). 日本癌学会総会記事 2019.09.01

  15. 石場 俊之, 有賀 智之, 中西 啓, 三木 義男. カルレチニンは乳腺葉状腫瘍における特異的マーカーとなりうる(Calretinin can be the specific marker for breast phyllodes tumor). 日本癌学会総会記事 2019.09.01

  16. 三木 義男. 家族性腫瘍発生の分子基盤と臨床(Familial cancer: Molecular basis and its implications for clinical practice). 日本癌学会総会記事 2019.09.01

  17. Gerelmaa Enkhbat, Uetake Hiroyuki, 中西 啓, 三木 義男. 細胞周期におけるBRCA2タンパク質レベル調節機構の解明(Elucidation of the regulation mechanism of BRCA2 protein levels in the cell cycle). 日本癌学会総会記事 2019.09.01

  18. 三木 義男. HBOC(遺伝性乳癌卵巣癌症候群) 遺伝子パネルによる乳がん発症危険度の遺伝学的検査 有効性・課題・展望. 日本癌治療学会学術集会抄録集 2018.10.01

  19. 砂田 成章, 三木 義男. DNA-PK阻害はPARP阻害剤誘発のDNA複製ストレスを回避させる(DNA-PK inhibition releases PARP inhibitor-induced DNA replication stress). 日本癌学会総会記事 2018.09.01

  20. 東條 陽, 佐藤 亜美, 斉藤 広子, 中西 啓, 三木 義男. エストロゲン誘導性BRCA2の機能解析(Analysis of the function of estrogen-mediated BRCA2). 日本癌学会総会記事 2018.09.01

  21. Deng Yu, 中西 啓, 三木 義男. エストロゲンによる乳管及び基底膜崩壊機構の解析(Analysis of disruption mechanism of the breast duct and basement membrane by estradiol). 日本癌学会総会記事 2018.09.01

  22. Osumi Hiroki, Shinozaki Eiji, Mashima Tetsuo, Wakatsuki Takeru, Suenaga Mitsukuni, Ichimura Takashi, Ogura Mariko, Ota Yumiko, Nakayama Izuma, Takahari Daisuke, Chin Keisho, Miki Yoshio, Yamaguchi Kensei. Phase II trial of biweekly cetuximab and irinotecan as third-line therapy for pretreated KRAS exon 2 wild-type colorectal cancer(和訳中). Cancer Science 2018.08.01

  23. Sunada Shigeaki, Nakanishi Akira, Miki Yoshio. 乳癌感受性遺伝子1/2変異癌のポリ(ADP-リボース)ポリメラーゼ阻害薬治療におけるDNA二重鎖切断修復経路のクロストーク(Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerise inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer). Cancer Science 2018.04.01

  24. Takaoka Miho, Ito Shun, Miki Yoshio, Nakanishi Akira. FKBP51 regulates cell motility and invasion via RhoA signaling. Cancer Science 2017.03.01

  25. Hiroko Saito, Miho Takaoka, Akira Nakanishi, Yoshio Miki. Loss of BRCA2 enhances microtubules more stabilization with PTX treatment. Tenth AACR-JCA Joint Conference 2016.02.16 USA

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