Personnel Information

写真a

MIKI Yoshio


Job title

Professor

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JAPAN

Mail Address

The inquiry by e-mail is 《here

Homepage URL

http://www.tmd.ac.jp/mri/mgen/index_j.html

Research Areas, Keywords

Carcinogenesis, Breast Cancer, Genome Medicine, Hereditary Cancer, Genome Stability Research

Graduating School 【 display / non-display

  • Wakayama Medical University, Faculty of Medicine, 1981.03, Graduated

Graduate School 【 display / non-display

  • Hyogo College of Medicine, Graduate School, Division of Medicine, Doctor's Course, Completed

Campus Career 【 display / non-display

  • 2002.04
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Medical Genomics, Molecular Genetics, Professor
  • 2002.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Applied Gene Medicine, Professor

External Career 【 display / non-display

  • , Trainee Resident

Academic Society Affiliations 【 display / non-display

  • Japanese Organization of Hereditary Breast and Ovarian Cancer(JOHBOC)

Research Areas 【 display / non-display

  • Tumor biology

  • Pathological medical chemistry

  • Human genetics

  • Medical genome science

Qualification Acquired 【 display / non-display

  • Doctor

 

Research Theme 【 display / non-display

  • Molecular Mechanisms of Breast Cancer Progression

  • Cancer Genome Research

  • Cell Death Signaling in Cancer

  • DNA Damage Repair and Genome Instability in Cancer

  • Hormone-Dependent Breast Cancer Cell Growth

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Published Papers & Misc 【 display / non-display

  • Yoshida R, Hagio T, Kaneyasu T, Gotoh O, Osako T, Tanaka N, Amino S, Yaguchi N, Nakashima E, Kitagawa D, Ueno T, Ohno S, Nakajima T, Nakamura S, Miki Y, Hirota T, Takahashi S, Matsuura M, Noda T, Mori S. Pathogenicity Assessment of Variants for Breast Cancer Susceptibility Genes Based on BRCAness of Tumor Sample. Cancer science. 2021.01; ( PubMed, DOI )

  • Chin YM, Takahashi Y, Chan HT, Otaki M, Fujishima M, Shibayama T, Miki Y, Ueno T, Nakamura Y, Low SK. Ultradeep targeted sequencing of circulating tumor DNA in plasma of early and advanced breast cancer. Cancer science. 2020.10; 112 (1): 454-464. ( PubMed, DOI )

  • Gao Y, Nihira NT, Bu X, Chu C, Zhang J, Kolodziejczyk A, Fan Y, Chan NT, Ma L, Liu J, Wang D, Dai X, Liu H, Ono M, Nakanishi A, Inuzuka H, North BJ, Huang YH, Sharma S, Geng Y, Xu W, Liu XS, Li L, Miki Y, Sicinski P, Freeman GJ, Wei W. Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nature cell biology. 2020.09; 22 (9): 1064-1075. ( PubMed, DOI )

  • Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T, Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nature genetics. 2020.07; 52 (7): 669-679. ( PubMed, DOI )

  • Deng Y, Miki Y, Nakanishi A. Estradiol/GPER affects the integrity of mammary duct-like structures in vitro. Scientific reports. 2020.01; 10 (1): 1386. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • XU ZEYU, GUO QIANQIAN, 斉藤 広子, 砂田 成章, 三木 義男. 遺伝性乳がん卵巣がんの原因遺伝子のVUSに対する相同組み換え活性に関する研究(Study on homologous recombination activities of VUSs in hereditary breast and ovarian cancer susceptibility genes). 日本癌学会総会記事 2019.09.01

  • 三木 義男. 家族性腫瘍発生の分子基盤と臨床(Familial cancer: Molecular basis and its implications for clinical practice). 日本癌学会総会記事 2019.09.01

  • Gerelmaa Enkhbat, Uetake Hiroyuki, 中西 啓, 三木 義男. 細胞周期におけるBRCA2タンパク質レベル調節機構の解明(Elucidation of the regulation mechanism of BRCA2 protein levels in the cell cycle). 日本癌学会総会記事 2019.09.01

  • 石場 俊之, 有賀 智之, 中西 啓, 三木 義男. カルレチニンは乳腺葉状腫瘍における特異的マーカーとなりうる(Calretinin can be the specific marker for breast phyllodes tumor). 日本癌学会総会記事 2019.09.01

  • DENG YU, 中西 啓, 三木 義男. エストロゲンによる乳管及び基底膜崩壊機構の解析(Mechanism of breast duct and basement membrane disruption caused by estradiol). 日本癌学会総会記事 2019.09.01

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