Graduating School 【 display / non-display 】

Graduating School 【 display / non-display 】

• The University of Tokyo, Faculty of Science, Biochemistry and biophysiology, 1986, Graduated

Graduate School 【 display / non-display 】

Graduate School 【 display / non-display 】

• The University of Tokyo, Graduate School, Division of Science, Biochemistry and biophysiology, Doctor's Course, 1986, Completed

Degree 【 display / non-display 】

Degree 【 display / non-display 】

• PhD, The University of Tokyo

Campus Career 【 display / non-display 】

Campus Career 【 display / non-display 】

• 1900.01

  -

  2018.03

  Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Biochemistry， Associate Professor
• 2018.04

  -

  2021.03

  Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Biochemistry， Associate Professor
• 2021.04

  -

  Now

  Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， -， Department of Biochemistry， Associate Professor

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

• Functional basic dentistry

• Structural biochemistry

• Functional biochemistry

Research Theme 【 display / non-display 】

Research Theme 【 display / non-display 】

• Cell-surface assembly of proteins, 2010

  Keyword： Protein Assembly, structural analysis, membrane
  State： Collaboration in Japan
  Summary： Investigations of protein assembly on the membrane are important to understand various cell-surface events. When an extracellular domain is isolatable, as in the case of single-transmembrane proteins or lipid-modified proteins, the intermolecular interaction can be precisely demonstrated by crystallographic analysis. However, since the motion of membrane proteins is restricted within a plane, it is necessary to confirm whether the interaction detected by the analysis of the extracellular domain is actually applicable to that occurring on the cell surface.We combined a crystallographic analysis with a newly developed site-specific crosslinking method applicable to mammalian cells.
  

Published Papers & Misc 【 display / non-display 】

Published Papers & Misc 【 display / non-display 】

• Daisuke Yamamoto, Kou Kayamori, Kei Sakamoto, Maiko Tsuchiya, Tohru Ikeda, Hiroyuki Harada, Tetsuya Yoda, Tetsuro Watabe, Miki Hara-Yokoyama. Intracellular claudin-1 at the invasive front of tongue squamous cell carcinoma is associated with lymph node metastasis. Cancer Sci.. 2020.02; 111 (2): 700-712. ( PubMed, DOI )

• Yuji Kato, Satoko Arakawa, Kazue Terasawa, Jin-Ichi Inokuchi, Takanori Iwata, Shigeomi Shimizu, Tetsuro Watabe, Miki Hara-Yokoyama. The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. Bioorg. Med. Chem. Lett.. 2020; 30 (3): 126891. ( PubMed, DOI )

• Hara-Yokoyama M, Kurihara H, Ichinose S, Matsuda H, Ichinose S, Kurosawa M, Tada N, Iwahara C, Terasawa K, Podyma-Inoue KA, Furukawa K, Iwabuchi K. KIF11 as a Potential Marker of Spermatogenesis Within Mouse Seminiferous Tubule Cross-sections. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2019.08; 22155419871027. ( PubMed, DOI )

• Jin-Ichi Inokuchi, Takashi Ode, Miki Hara-Yokoyama. Pharmacological Modulation of Glycosphingolipid Metabolism. Methods Mol. Biol.. 2018; 1804 401-410. ( PubMed, DOI )

• 井上 カタジナ・アンナ, 高橋 和樹, 松田 匠源, 吉松 康裕, 横山 三紀, 渡部 徹郎. TGF-β誘発性上皮間葉転換中の口腔扁平上皮癌細胞が分泌するエキソソーム(Exosomes secreted by oral squamous carcinoma cells undergoing TGF-β-induced epithelial to mesenchymal transition) 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-0028]. ( ichushi )

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Conference Activities & Talks 【 display / non-display 】

Conference Activities & Talks 【 display / non-display 】

• Kazue Terasawa, Seisuke Kusano, Shigeyuki Yokoyama, Tetsuro Watabe, Miki Yokoyama. LAMP-1 and LAMP-2 with tandem b-prism domains assemble via distinct modes. The 37th Annual Meetings of Japanesease Society of Carbohydrate Research 2018.08.29 Sendai

• Miki Hara-Yokoyama, Shizuko Ichinose, Kumiko Ishii, Hidetake Kurihara, Shozo Ichinose, Keiko Tadano-Aritomi, Norihiro Tada, Kazue Terasawaa, Katarzyna A. Podyma-Inoue, Toshihide Kobayashi, Koichi Furukawa, Masaki Yanagishita, and Kazuhisa Iwabuchi. Very-long chain polyenoic glycosphingolipids are required for remodeling of blood testis barrier . The 87th annual meeting of Japanese Biochemistry Society 2014.10.17 Kyoto

• Kazue Terasawa, Yuji Kato, Yuta Ikami, Kensaku Sakamoto, Kazumasa Ohtake, Tetsuro Watabe, Shigeyuki Yokoyama, and Miki Hara-Yokoyama. Homophilic interaction of the luminal domain of LAMP-2 is important for chaperone-mediated autophagy. The 93rd Annual Meeting of the Japanese Biochemical Society 2020.09.14 Web holding

• Yuji Kato, Satoko Arakawa, Kazue Terasawa, Jin-ichi Inokuchi, Takanori Iwata, Shigeomi Shimizu, Tetsuro Watabe, and Miki Hara-Yokoyama. The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. The 62nd Japan Lipid Chemistry Society 2020.05.14 Funabori

• Kato.Y, Terasawa.K, Watabe.T, Aoki.A, Iwata.T, Yokoyama.M. Role of LAMP-2 assembly in Autolysosome formation. 2019.05.24

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