Personnel Information

写真a

TSUBATA Takeshi


Job title

Visiting Lecturer

Laboratory Address

1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan

Mail Address

The inquiry by e-mail is 《here

Research Areas, Keywords

immune response, antibody, glycan antigens, autoimmunity, infection immunity, apoptosis, vesicular transport, ROS

Graduating School 【 display / non-display

  • Kyoto University, Faculty of Medicine, 1981, Graduated

Graduate School 【 display / non-display

  • Kyoto University, Graduate School, Division of Medicine, Doctor's Course, 1987, Completed

Degree 【 display / non-display

  • Doctor, Kyoto University

Campus Career 【 display / non-display

  • 1996.07
    -
    2003.03
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Immunology, Professor
  • 2003.04
    -
    2010.03
    Tokyo Medical and Dental University, Director
  • 2010.04
    -
    2022.03
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Immunology, Professor
  • 2012.04
    -
    2014.12
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Immunology, Professor
  • 2012.04
    -
    2021.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Immunology, Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Immunology, Visiting Lecturer

▼display all

External Career 【 display / non-display

  • , Associate Professor
  • , Associate Professor

Research Areas 【 display / non-display

  • Immunology

  • Medical biochemistry

 

Published Papers & Misc 【 display / non-display

  1. Li Y, Tang Y, Liu J, Meng X, Wang Y, Min Q, Hong R, Tsubata T, Hase K, Wang JY. Glia maturation factor-γ is involved in S1P-induced marginal zone B cell chemotaxis and optimal T-independent type II antigen-induced IgM production. International immunology. 2021.12; in press ( PubMed, DOI )

  2. Tsubata, T. Role of inhibitory B cell co-receptors in B cell self-tolerance to non-protein antigens Immunological Reviews. 2021.12; in press ( DOI )

  3. Long, W., Kunitake, S., Sawada, S., Akiyoshi, K. and Tsubata, T. Protein antigen conjugated with cholesteryl amino-pullulan nanogel shows delayed degradation in dendritic cells and augmented immunogenicity. Vaccine. 2021.12; 39 7526-7530. ( PubMed, DOI )

  4. Akatsu, C., Alborzian Deh Sheikh, A., Matsubara, N., Takematsu, H., Schweizer, A., Abdu-Allah, H. H. M., Tedder, T. F., Nitschke, L., Ishida, H. and Tsubata, T. Inhibitory co-receptor CD22 restores B cell signaling by developmentally regulating Cd45-/- immunodeficient B cells. Sci. Signal. 2021.12; in press

  5. Alborzian Deh Sheikh, A, Akatsu, C., Abdu-Allah, H. H. M., Suganuma, Y., Imamura, A., Ando, H., Takematsu, H., Ishida, H. and Tsubata, T. The protein tyrosine phosphatase SHP-1 (PTPN-6) but not CD45 (PTPR-C) is essential for the ligand-mediated regulation of CD22 in BCR-ligated B cells J. Immunol. 2021.06; 206 (11): 2544-2551. ( PubMed, DOI )

  6. Ballet, R., Brennan, M., Brandl, C., Feng, N., Berri, J., Cheng, J., Ocón, B., Alborzian Deh Sheikh, A., Marki, A., Bi,Y., Abram, C. L., Lowell, C. A., Tsubata, T., Greenberg, H. B., Macauley, M. S., Ley, K., Nitschke, L., Butcher. E. C. CD22-Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity Nature Immunology. 2021.02; 22 381-390.

  7. Tsugawa, N., Yamada, D., Watabe, T., Onizawa, M., Wang, S., Nemoto, Y., Oshima, S., Tsubata, T., Adachi, T., Kawano, Y., Watanabe, M., Blumberg, RS., Okamoto, R., Nagaishi, T. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation. Biochemical and Biophysical Research Communications. 2021.01; 535 99-105. ( PubMed, DOI )

  8. Alborzian Deh Sheikh, A., Gomaa, S., Li, X., Routledge, M., Saigoh, K., Numoto, N., Angata, T., Hitomi, Y., Takematsu, H., Tsuiji, M., Ito, N., Kusunoki, S., Tsubata, T. A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides. Journal of Autoimmunity. 2021.01; 116 102571. ( PubMed, DOI )

  9. Alborzian Deh Sheikh, A., Akatsu, C. and Tsubata, T. . Identification of Siglec Cis-ligands by Proximity Labeling Methods. Mol. Biol. 2020.04; 2132 75-83. ( PubMed, DOI )

  10. Hong, R., Lai, N., Xiong, E., Ouchida, R., Sun, J., Zhou, Y., Tang, Y., Hikida, M., Tsubata, T., Tagawa, M., Wang, Y. and Wang, J.-y. Distinct roles of BCNP1 in B cell development and activation. International Immunology. 2020.01; 32 (1): 17-26. ( DOI )

  11. Tsubata, T. Involvement of reactive oxygen species (ROS) in BCR signaling as a second messenger. 2020; 1254 37-46. ( DOI )

  12. Tang Yue, Lai Nannan, Xiong Ermeng, Ouchida Rika, Sun Jiping, Hikida Masaki, Tsubata Takeshi, Wang Yanqing, Wang Ji-Yang. Regulation of B cell development, activation, and function Distinct roles of B cell novel protein 1 in B cell development and activation 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 2-F. ( ichushi )

  13. Nishida Kyoko, Kimura Akihiro, Tsubata Takeshi, Suzuki Harumi. T cell response Anti-oxidative enzyme NAD(P)H quinone oxidoreductase1 promotes Th17 cells differentiation by protecting oxidative stress 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 1-C. ( ichushi )

  14. Akatsu Chizuru, Li Quan-Zhen, Sekine Hideharu, Fujita Teizo, Tsubata Takeshi. Systemic lupus erythematosus and other systemic autoimmune diseases The inhibitory B cell co-receptor CD72 recognizes various lupus self-antigens including C1q and inhibits B cell responses to these self-antigen 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 2-B. ( ichushi )

  15. Tsubata Takeshi. Regulation of B cells and autoimmune diseases 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): OT11. ( ichushi )

  16. Liu Jun, Qian Jiawen, Xiong Ermeng, Zhang Lumin, Wang Yanqing, Chu Yiwei, Tsubata Takeshi, Wang Ji-Yang. Regulation of B cell development, activation, and function Role of the IgM Fc receptor in marginal zone B cell development and function 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 2-F. ( ichushi )

  17. Xiong Ermeng, Cao Chaoqun, Min Qing, Liu Jun, Lai Nannan, Wang Ying, Matsumoto Ryohtaroh, Takahashi Daisuke, Hase Koji, Shinkura Reiko, Tsubata Takeshi, Wang Ji-Yang. Regulation of B cell development, activation, and function MZB1 promotes the secretion of J chain-containing IgA and is critical for the suppression of gut inflammation 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 2-F. ( ichushi )

  18. Wang Ying, Liu Jun, Xiong Ermeng, Akatsu Chizuru, Tsubata Takeshi, Wang Ji-Yang. Regulation of B cell development, activation, and function LAPTM5 mediates anti-IgM-induced apoptosis in immature B cells 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 2-F. ( ichushi )

  19. Feng Yang-Yang, Liu Jun, Wang Ji-Yang, Tsubata Takeshi. Regulation of B cell development, activation, and function Essential role of late redoxosome in BCR ligation-induced B cell activation 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 2-F. ( ichushi )

  20. Tsubata Takeshi. Inhibitory B cell co-receptors and autoimmune diseases Immunological Medicine. 2019.09; 42 (3): 108-116. ( ichushi )

  21. Xiong Ermeng, Li Yingqian, Min Qing, Cui Chaoqun, Liu Jun, Hong Rongjian, Lai Nannan, Wang Ying, Sun Jiping, Matsumoto Ryohtaroh, Takahashi Daisuke, Hase Koji, Shinkura Reiko, Tsubata Takeshi, Wang Ji-Yang. MZB1 promotes the secretion of J-chain-containing dimeric IgA and is critical for the suppression of gut inflammation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019.07; 116 (27): 13480-13489. ( PubMed, DOI )

  22. Feng Yang-Yang, Tang Miao, Suzuki Mitsuhiro, Gunasekara Chinthika, Anbe Yuki, Hiraoka Yuichi, Liu Jun, Grasberger Helmut, Ohkita Mamoru, Matsumura Yasuo, Wang Ji-Yang, Tsubata Takeshi. Essential Role of NADPH Oxidase-Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation JOURNAL OF IMMUNOLOGY. 2019.05; 202 (9): 2546-2557. ( DOI )

  23. Hong R, Lai N, Ouchida R, Xiong E, Zhou Y, Min Q, Liu J, Tang Y, Hikida M, Tsubata T, Wang Y, Wang JY. The B cell novel protein 1 (BCNP1) regulates BCR signaling and B cell apoptosis. European journal of immunology. 2019.03; 49 911-917. ( PubMed, DOI )

  24. Tsubata T. CD72 is a Negative Regulator of B Cell Responses to Nuclear Lupus Self-antigens and Development of Systemic Lupus Erythematosus. Immune network. 2019.02; 19 (1): e1. ( PubMed, DOI )

  25. Hong Rongjian, Lai Nannan, Xiong Ermeng, Ouchida Rika, Sun Jiping, Zhou Yang, Tang Yue, Hikida Masaki, Tsubata Takeshi, Tagawa Masatoshi, Wang Yanqing, Wang Ji-Yang. Distinct roles of BCNP1 in B-cell development and activation International Immunology. 2019; 32 (1): 17-26. ( ichushi )

  26. Tsubata Takeshi. Ligand Recognition Determines the Role of Inhibitory B Cell Co-receptors in the Regulation of B Cell Homeostasis and Autoimmunity. Frontiers in Immunology. 2018.10; 9 2276. ( PubMed, DOI )

  27. Lino, A. C., Dang, V. D., Lampropoulou, V., Welle, A., Joedicke, J., Pohar, J., Simon, Q., Thalmensi, J., Baures, A., Fluehler, V., Sakwa, I., Stervbo, U., Ries, S., Jouneau, L., Boudinot., P., Tsubata, T. Adachi, T., Hutloff, A., Doener, T., Zimber-Strobl, U., de Vos, A. F., Dahlke, K., Loh, G., Komiotis, S., Goosmann, C., Weill, J.-C., Raynaud, C.-A., Kaufmann, S. H. E., Walter, J. and Fillatreau, S. . LAG-3 expression identifies immunosuppressive natural regulatory plasma cells. 2018.07; 49 (1): 120-133. ( DOI )

  28. Li Shuyin, Liu Jun, Min Qing, Ikawa Tomokatsu, Yasuda Shoya, Yang Yang, Wang Yan-Qing, Tsubata Takeshi, Zhao Yaofeng, Wang Ji-Yang. Ketch-like protein 14 promotes B-1a but suppresses B-1b cell development. International Immunology. 2018.07; 30 (7): 311-318. ( PubMed, DOI )

  29. Matsubara, N., Imamura, A., Yonemizu, T., Akatsu, C., Yang, H., Ueki, A., Watanabe, N., Abdu-Allah, H., Numoto, N., Takematsu, H., Kitazume, S., Tedder, T. F., Marth, J. D., Ito, N., Ando, H., Ishida, H., Kiso, M. and Tsubata, T. . CD22-binding synthetic sialosides regulate B lymphocyte proliferation through CD22 ligand-dependent and independent pathways, and enhance antibody production in mice. Front. Immunol. . 2018.04; 9 830. ( DOI )

  30. Liu, J., Zhu, H., Qian, J., Xiong, E., Zhang, L., Chu, Y., Kubagawa, H., Tsubata, T. and Wang, J.-Y. . Fcμ Receptor promotes the survival and activation of marginal zone B cells and protects mice against bacterial sepsis. Front. Immunol. 2018.02; 9 160-169. ( PubMed, DOI )

  31. Tsubata, T. Negative regulation of B cell responses and self-tolerance to RNA-related lupus self-antigen. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 2018.01; 94 (1): 35-44.

  32. Amin Alborzian Deh Sheikh, Akatsu Chizuru, Imamura Akihiro, Abdu-Allah Hajjaj H. M., Takematsu Hiromu, Ando Hiromune, Ishida Hideharu, Tsubata Takeshi. Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise alpha 2,6 sialic acid-dependent and -independent interactions. Biochemical and biophysical research communications. 2018.01; 495 (1): 854-859. ( PubMed, DOI )

  33. Feng Yangyang, Rengarajan Sundararaman, Tang Miao, Tsubata Takeshi. B cell development and function Role of NADPH oxidases in BCR ligation-induced ROS production and activation(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-E. ( ichushi )

  34. Tsubata Takeshi, Yang Hongrui, Akatsu Chizuru. Innate Immune Sensors and Diseases CD72 recognizes RNA-related self-antigens and prevents autoimmunity(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): S2-4. ( ichushi )

  35. NISHIDA Kyoko, KIMURA Akihiro, TSUBATA Takeshi, SUZUKI Harumi. Helper T cells NQO1 play a pathogenic role in autoimmune diseases through the suppression of IL-10 production in Th17 cells(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 1-I. ( ichushi )

  36. Liu, J., Xiong, E., Zhu, H., Mori, H., Yasuda, S., Kinoshita, K., Tsubata, T. and Wang, J.-Y. . Efficient induction of Ig gene hypermutation in ex vivo-activated primary B cells J. Immunol. 2017.11; 199 (9): 3023-3030.

  37. Alborzian Deh Sheikh, A., Akatsu, C., Imamura, A., Abdu-Allah, H. H. M., Takematsu, H., Ando, H., Ishida, H. and Tsubata, T.. Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise α2,6 sialic acid-dependent and -independent interactions. Biochem. Biophys. Res. Comm. (Epub). 2017.11; 495 854-859.

  38. Liu Jun, Xiong Ermeng, Zhu Hanying, Mori Hiromi, Yasuda Shoya, Kinoshita Kazuo, Tsubata Takeshi, Wang Ji-Yang. Efficient Induction of Ig Gene Hypermutation in Ex Vivo-Activated Primary B Cells JOURNAL OF IMMUNOLOGY. 2017.11; 199 (9): 3023-3030. ( PubMed, DOI )

  39. Numoto Nobutaka, Akatsu Chizuru, Shinagawa Kenro, Tsubata Takeshi, Ito Nobutoshi. B細胞抑制性因子CD72の分子表面電荷分布によるリガンド結合制御機構(Charge distribution regulates the ligand-binding affinity of B cell inhibitory receptor CD72) 生物物理. 2017.08; 57 (Suppl.1-2): S276. ( ichushi )

  40. Tsubata, T. B cell tolerance and autoimmunity F1000Research. 2017.03; 6 391.

  41. Tsubata T.. CD22 and CD72 are inhibitory receptors dominantly expressed in B lymphocytes and regulate systemic autoimmune diseases English version ZEITSCHRIFT FUR RHEUMATOLOGIE. 2017.03; 76 10-13. ( DOI )

  42. Tsubata T. B-cell tolerance and autoimmunity. F1000Research. 2017; 6 391. ( PubMed, DOI )

  43. Akatsu Chizuru, Shinagawa Kenro, Numoto Nobutaka, Liu Zhihong, Ucar Ayse Konuskan, Aslam Mohammad, Phoon Shirly, Adachi Takahiro, Furukawa Koji, Ito Nobutoshi, Tsubata Takeshi. CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP JOURNAL OF EXPERIMENTAL MEDICINE. 2016.11; 213 (12): 2691-2706. ( PubMed, DOI )

  44. Li Yingqian, Takahashi Yoshimasa, Fujii Shin-ichiro, Zhou Yang, Hong Rongjian, Suzuki Akari, Tsubata Takeshi, Hase Koji, Wang Ji-Yang. EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity NATURE COMMUNICATIONS. 2016.03; 7 10836. ( PubMed, DOI )

  45. Li, Y., Takahashi, Y., Fujii, S., Suzuki, A., Tsubata, T., Hase, K. and Wang, J-Y.. EAF2 mediates germinal center B cell apoptosis to suppress excessive immune responses and prevent autoimmunity Nature Communications. 2016; 7 (10836):

  46. Tsubata, T.. CD22 and CD72 are inhibitory receptors dominantly expressed in B lymphocytes and regulate systemic autoimmune diseases. Z. Rheumatol.. 2016; 75 86-89.

  47. Ouchida. R., Lu. Q., Liu. J., Li. Y., Chu. Y., Tsubata. T. and Wang, J.-Y.. FcμR interacts and cooperates with the B cell receptor to promote B cell survival J. Immunol. 2015.04; 194 3096-3101. ( PubMed )

  48. Muro. R., Nitta. T., Okada. T., Ideta. H., Tsubata. T. and Suzuki. H.. The Ras GTPase-activating protein Rasal3 supports survival of naive T cells PLoS ONE. 2015.03; 10 (3): e0119898. ( PubMed, DOI )

  49. Ouchida. R., Lu. Q., Liu. J., Li. Y., Chu. Y., Tsubata. T. and Wang, J.Y.. FcμR interacts and cooperates with the B cell receptor to promote B cell survival. J. Immunol. . 2014.12; 194 3096-3101.

  50. Muro R, Nitta T, Okada T, Ideta H, Tsubata T, Suzuki H.. The Ras GTPase-Activating Protein Rasal3 Supports Survival of Naive T Cells. PLoS One.. 2014.12; 10 e0119898..

  51. Takematsu Hiromu, Naito-Matsui Yuko, Tsubata Takeshi, Oka Shogo. Functional evaluation of sialoglycans expressed in activated T cells GLYCOBIOLOGY. 2014.11; 24 (11): 1091-1092.

  52. Miyata Yoshihiko, Shibata Takeshi, Aoshima Masato, Tsubata Takuichi, Nishida Eisuke. The Molecular Chaperone TRiC/CCT Binds to the Trp-Asp 40 (WD40) Repeat Protein WDR68 and Promotes Its Folding, Protein Kinase DYRK1A Binding, and Nuclear Accumulation JOURNAL OF BIOLOGICAL CHEMISTRY. 2014.11; 289 (48): 33320-33332. ( DOI )

  53. Kawai, Y., Ouchida, R., Yamasaki, S., Dragone, L., Tsubata, T. and Wang, J.-Y.. LAPTM5 promotes lysosomal degradation of intracellular CD3zeta but not of cell surface CD3ζ. Immunol. Cell Biol. . 2014.07; 92 527-534.

  54. Kawai Yohei, Ouchida Rika, Yamasaki Sho, Dragone Leonard, Tsubata Takeshi, Wang Ji-Yang. LAPTM5 promotes lysosomal degradation of intracellular CD3 zeta but not of cell surface CD3 zeta IMMUNOLOGY AND CELL BIOLOGY. 2014.07; 92 (6): 527-534. ( PubMed, DOI )

  55. Tsubata, T. . Siglecs and B cell regulation. In: Taniguchi N., Endo T., Hart G., Seeberger P., Wong C. (Ed.) Glycoscience: Biology and Medicine SpringerReference (www.springerreference.com). Springer-Verlag Berlin Heidelberg. . 2014.04;

  56. Aslam, M., Kishi, Y. and Tsubata, T. . Excess CD40L does not rescue anti-DNA B cells from clonal anergy. F1000Res. 2014.01; 2 218.

  57. Naito-Matsui Yuko, Takada Shuhei, Kano Yoshinobu, Iyoda Tomonori, Sugai Manabu, Shimizu Akira, Inaba Kayo, Nitschke Lars, Tsubata Takeshi, Oka Shogo, Kozutsumi Yasunori, Takematsu Hiromu. Functional Evaluation of Activation-dependent Alterations in the Sialoglycan Composition of T Cells JOURNAL OF BIOLOGICAL CHEMISTRY. 2014.01; 289 (3): 1564-1579. ( PubMed, DOI )

  58. Naito-Matsui, Y., Takada, S., Kano, Y., Iyoda, T., Sugai, M, Shimizu, A., Inaba, K., Nitschke, L., Tsubata, T., Oka, S., Kozutsumi, Y. and Takematsu, H. . Functional evaluation of activation-dependent alterations in the sialogylcan composition of T cells. J. Biol. Chem. . 2014; 289 1564-1579.

  59. Maeno, E., Tsubata, T. and Okada, Y . Apoptotic volume decrease (AVD) is independent of mitochondrial dysfunction and initiator caspase activation. Cells. 2013.11; (1): 1156-1167.

  60. Xu Miduo, Hou Rong, Sato-Hayashizaki Aya, Man Rongyong, Zhu Chenghua, Wakabayashi Chisato, Hirose Sachiko, Adachi Takahiro, Tsubata Takeshi. Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease. J Immunol. 2013.06; 190 (11): 5436-5445. ( PubMed, DOI )

  61. Koni Pandelakis A, Bolduc Anna, Takezaki Mayuko, Ametani Yutetsu, Huang Lei, Lee Jeffrey R, Nutt Stephen L, Kamanaka Masahito, Flavell Richard A, Mellor Andrew L, Tsubata Takeshi, Shimoda Michiko. Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction. J Immunol. 2013.04; 190 (7): 3189-3196. ( PubMed, DOI )

  62. Kishi, Y., Higuchi, T., Phoon, S., Kamiya, K., Riemekasten, G., Akiyoshi, K., Weigert, M. and Tsubata, T.. Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells. Proc. Natl. Acad. Sci. USA . 2012.06; (109): 7811-7816.

  63. Shimoda Michiko, Bolduc Anna, Powell Domonica, Ametani Yutetsu, Takezaki Mayuko, Nutt Stephen, Kamanaka Masahito, Flavell Richard, Mellor Andrew, Tsubata Takeshi, Koni Pandelakis. A critical role of dendritic cells in CD8 T cell IL-10 expression during inflammatory response triggered by CD40-activated B cells JOURNAL OF IMMUNOLOGY. 2012.05; 188

  64. Klionsky Daniel J, Abdalla Fabio C, Abeliovich Hagai, Abraham Robert T,Tsubata T. et al.. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012.04; 8 (4): 445-544. ( PubMed )

  65. Tsubata T. Role Of Inhibitory Bcr Co-Receptors In Immunity. Infect Disord Drug Targets. 2012.03; ( PubMed )

  66. Hitomi Yuki, Adachi Takahiro, Tsuchiya Naoyuki, Honda Zen-Ichiro, Tokunaga Katsushi, Tsubata Takeshi. Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum. BMC Immunol. 2012; 13 72. ( PubMed, DOI )

  67. Watanabe K, Tsuchiya Y, Kawaguchi Y, Sawada S, Ayame H, Akiyoshi K, Tsubata T. The use of cationic nanogels to deliver proteins to myeloma cells and primary T lymphocytes that poorly express heparan sulfate. Biomaterials. 2011.09; 32 (25): 5900-5905. ( PubMed, DOI )

  68. Abdu-Allah Hajjaj H. M., Watanabe Kozo, Daikoku Shusaku, Kanie Osamu, Tsubata Takeshi, Ando Hiromune, Ishida Hideharu, Kiso Makoto. Design and Synthesis of a Multivalent Heterobifunctional CD22 Ligand as a Potential Immunomodulator SYNTHESIS-STUTTGART. 2011.09; (18): 2968-2974. ( DOI )

  69. Abdu-Allah HH, Watanabe K, Completo GC, Sadagopan M, Hayashizaki K, Takaku C, Tamanaka T, Takematsu H, Kozutsumi Y, Paulson JC, Tsubata T, Ando H, Ishida H, Kiso M. CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold. Bioorg Med Chem. 2011.03; 19 (6): 1966-1971. ( PubMed, DOI )

  70. Poe JC, Smith SH, Haas KM, Yanaba K, Tsubata T, Matsushita T, Tedder TF. Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. PLoS One. 2011; 6 (7): e22464. ( PubMed, DOI )

  71. Magesh S, Ando H, Tsubata T, Ishida H, Kiso M. High-affinity ligands of Siglec receptors and their therapeutic potentials. Curr Med Chem. 2011; 18 (23): 3537-3550. ( PubMed )

  72. Kishi Y, Aiba Y, Higuchi T, Furukawa K, Tokuhisa T, Takemori T, Tsubata T. Augmented antibody response with premature germinal center regression in CD40L transgenic mice. J Immunol. 2010.07; 185 (1): 211-219. ( PubMed, DOI )

  73. Bolduc A, Long E, Stapler D, Cascalho M, Tsubata T, Koni PA, Shimoda M. Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas. J Immunol. 2010.07; 185 (1): 220-230. ( PubMed, DOI )

  74. Ishiura N, Nakashima H, Watanabe R, Kuwano Y, Adachi T, Takahashi Y, Tsubata T, Okochi H, Tamaki K, Tedder TF, Fujimoto M. Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. Eur J Immunol. 2010.04; 40 (4): 1192-1204. ( PubMed, DOI )

  75. Man RY, Onodera T, Komatsu E, Tsubata T. Augmented B lymphocyte response to antigen in the absence of antigen-induced B lymphocyte signaling in an IgG-transgenic mouse line. PLoS One. 2010; 5 (1): e8815. ( PubMed, DOI )

  76. Tanaka Mai, Imai Nori, Tsubata Takeshi, Tsuiji Makoto. The Immune Responses during the Primary Phase Against Cupsular Polysaccharides of Streptococcus Pneumoniae GLYCOBIOLOGY. 2009.11; 19 (11): 1358.

  77. Abdu-Allah HH, Watanabe K, Hayashizaki K, Takaku C, Tamanaka T, Takematsu H, Kozutsumi Y, Tsubata T, Ishida H, Kiso M. Potent small molecule mouse CD22-inhibitors: exploring the interaction of the residue at C-2 of sialic acid scaffold. Bioorg Med Chem Lett. 2009.10; 19 (19): 5573-5575. ( PubMed, DOI )

  78. Engels N, Konig LM, Heemann C, Lutz J, Tsubata T, Griep S, Schrader V, Wienands J. Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells. Nat Immunol. 2009.09; 10 (9): 1018-1025. ( PubMed, DOI )

  79. Hombach J, Tsubata T, Leclercq L, Stappert H, Reth M. Molecular components of the B-cell antigen receptor complex of the IgM class. 1990. J Immunol. 2009.08; 183 (3): 1505-1507. ( PubMed )

  80. Abdu-Allah Hajjaj H. M., Watanabe Kozo, Hayashizaki Koji, Iwayama Yuki, Takematsu Hiromu, Kozutsumi Yasunori, Tsubata Takeshi, Ishida Hideharu, Kiso Makoto. Synthesis of biotinylated sialoside to probe CD22-ligand interactions TETRAHEDRON LETTERS. 2009.08; 50 (31): 4488-4491. ( DOI )

  81. Yanaba K, Bouaziz JD, Matsushita T, Tsubata T, Tedder TF. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol. 2009.06; 182 (12): 7459-7472. ( PubMed, DOI )

  82. Kishi Y, Tsubata T. Apoptosis of marginal zone B-cells in unimmunized mice. J Med Dent Sci. 2009.03; 56 (1): 49-54. ( PubMed )

  83. Hou R, Ohtsuji M, Ohtsuji N, Zhang L, Adachi T, Hirose S, Tsubata T. Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72b congenic mice. Biochem Biophys Res Commun. 2009.02; 380 (1): 193-197. ( PubMed, DOI )

  84. Toda M, Hisano R, Yurugi H, Akita K, Maruyama K, Inoue M, Adachi T, Tsubata T, Nakada H. Ligation of tumour-produced mucins to CD22 dramatically impairs splenic marginal zone B-cells. Biochem J. 2009.02; 417 (3): 673-683. ( PubMed, DOI )

  85. Watanabe K, Tsubata T. Autophagy connects antigen receptor signaling to costimulatory signaling in B lymphocytes. Autophagy. 2009.01; 5 (1): 108-110. ( PubMed )

  86. Higuchi T., Tsubata T.. Ectopic expression of CD40 ligand on B cells abrogates clonal deletion of double-stranded DNA-reactive B Cells and induces lupus-like autoimmune disease ARCHIVES OF DERMATOLOGICAL RESEARCH. 2009.01; 301 (1): 46.

  87. Abdu-Allah HH, Tamanaka T, Yu J, Zhuoyuan L, Sadagopan M, Adachi T, Tsubata T, Kelm S, Ishida H, Kiso M. Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors. J Med Chem. 2008.11; 51 (21): 6665-6681. ( PubMed, DOI )

  88. Watanabe K, Ichinose S, Hayashizaki K, Tsubata T. Induction of autophagy by B cell antigen receptor stimulation and its inhibition by costimulation. Biochem Biophys Res Commun. 2008.09; 374 (2): 274-281. ( PubMed, DOI )

  89. Engels N., Heemann C., Koenig L., Tsubata T., Griep S., Schrader V., Wienands J.. Antigen receptor tail clue of class-switched memory B cells WIENER KLINISCHE WOCHENSCHRIFT. 2008.08; 120 51.

  90. Fujimoto Manabu, Ishiura Nobuko, Adachi Takahiro, Tsubata Takeshi, Tedder Thomas F., Tamaki Kunihiko. Distinctive tyrosine phosphorylation pattern of CD19 during BCR and CD40 signaling FASEB JOURNAL. 2008.04; 22

  91. Adachi T, Tsubata T. FRET-based Ca2+ measurement in B lymphocyte by flow cytometry and confocal microscopy. Biochem Biophys Res Commun. 2008.03; 367 (2): 377-382. ( PubMed, DOI )

  92. Yan BC, Adachi T, Tsubata T. ER stress is involved in B cell antigen receptor ligation-induced apoptosis. Biochem Biophys Res Commun. 2008.01; 365 (1): 143-148. ( PubMed, DOI )

  93. Onodera T, Poe JC, Tedder TF, Tsubata T. CD22 regulates time course of both B cell division and antibody response. J Immunol. 2008.01; 180 (2): 907-913. ( PubMed )

  94. Zhu C, Sato M, Yanagisawa T, Fujimoto M, Adachi T, Tsubata T. Novel binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in CD22 activated by B lymphocyte stimulation with antigen. J Biol Chem. 2008.01; 283 (3): 1653-1659. ( PubMed, DOI )

  95. Adachi T, Wienands J, Tsubata T, Kurosaki T. Interdomain A is crucial for ITAM-dependent and -independent regulation of Syk. Biochem Biophys Res Commun. 2007.12; 364 (1): 111-117. ( PubMed, DOI )

  96. Yu J, Sawada T, Adachi T, Gao X, Takematsu H, Kozutsumi Y, Ishida H, Kiso M, Tsubata T. Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts. Biochem Biophys Res Commun. 2007.09; 360 (4): 759-764. ( PubMed, DOI )

  97. Ono Y, Hayashi C, Doi N, Kitamura F, Shindo M, Kudo K, Tsubata T, Yanagida M, Sorimachi H. Comprehensive survey of p94/calpain 3 substrates by comparative proteomics--possible regulation of protein synthesis by p94. Biotechnol J. 2007.05; 2 (5): 565-576. ( PubMed, DOI )

  98. Sato M, Adachi T, Tsubata T. Augmentation of signaling through BCR containing IgE but not that containing IgA due to lack of CD22-mediated signal regulation. J Immunol. 2007.03; 178 (5): 2901-2907. ( PubMed )

  99. Akagawa M, Ito S, Toyoda K, Ishii Y, Tatsuda E, Shibata T, Yamaguchi S, Kawai Y, Ishino K, Kishi Y, Adachi T, Tsubata T, Takasaki Y, Hattori N, Matsuda T, Uchida K. Bispecific abs against modified protein and DNA with oxidized lipids. Proc Natl Acad Sci U S A. 2006.04; 103 (16): 6160-6165. ( PubMed, DOI )

  100. Tsubata T. B cell abnormality and autoimmune disorders. Autoimmunity. 2005.08; 38 (5): 331-337. ( PubMed )

  101. Kawamura T, Kanai T, Dohi T, Uraushihara K, Totsuka T, Iiyama R, Taneda C, Yamazaki M, Nakamura T, Higuchi T, Aiba Y, Tsubata T, Watanabe M. Ectopic CD40 ligand expression on B cells triggers intestinal inflammation. J Immunol. 2004.05; 172 (10): 6388-6397. ( PubMed )

  102. Hirai H, Adachi T, Tsubata T. Involvement of cell cycle progression in survival signaling through CD40 in the B-lymphocyte line WEHI-231. Cell Death Differ. 2004.03; 11 (3): 261-269. ( PubMed, DOI )

  103. Hokazono Y, Adachi T, Wabl M, Tada N, Amagasa T, Tsubata T. Inhibitory coreceptors activated by antigens but not by anti-Ig heavy chain antibodies install requirement of costimulation through CD40 for survival and proliferation of B cells. J Immunol. 2003.08; 171 (4): 1835-1843. ( PubMed )

  104. Suzuki A, Kaisho T, Ohishi M, Tsukio-Yamaguchi M, Tsubata T, Koni PA, Sasaki T, Mak TW, Nakano T. Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med. 2003.03; 197 (5): 657-667. ( PubMed )

  105. Wakabayashi C, Adachi T, Wienands J, Tsubata T. A distinct signaling pathway used by the IgG-containing B cell antigen receptor. Science. 2002.12; 298 (5602): 2392-2395. ( PubMed, DOI )

  106. Tsubata T. [Regulation of B lymphocyte activation and tolerance by costimulation and co-receptors] Tanpakushitsu Kakusan Koso. 2002.12; 47 (16 Suppl): 2248-2253. ( PubMed )

  107. Higuchi T, Aiba Y, Nomura T, Matsuda J, Mochida K, Suzuki M, Kikutani H, Honjo T, Nishioka K, Tsubata T. Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. J Immunol. 2002.01; 168 (1): 9-12. ( PubMed )

  108. Adachi T, Wienands J, Wakabayashi C, Yakura H, Reth M, Tsubata T. SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. J Biol Chem. 2001.07; 276 (28): 26648-26655. ( PubMed, DOI )

  109. Suzuki A, Yamaguchi MT, Ohteki T, Sasaki T, Kaisho T, Kimura Y, Yoshida R, Wakeham A, Higuchi T, Fukumoto M, Tsubata T, Ohashi PS, Koyasu S, Penninger JM, Nakano T, Mak TW. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 2001.05; 14 (5): 523-534. ( PubMed )

  110. Tsubata T. Molecular mechanisms for apoptosis induced by signaling through the B cell antigen receptor. Int Rev Immunol. 2001; 20 (6): 791-803. ( PubMed )

  111. Tsubata T, Wienands J. B cell signaling. Introduction. Int Rev Immunol. 2001; 20 (6): 675-678. ( PubMed )

  112. Nagaoka H, Takahashi Y, Hayashi R, Nakamura T, Ishii K, Matsuda J, Ogura A, Shirakata Y, Karasuyama H, Sudo T, Nishikawa S, Tsubata T, Mizuochi T, Asano T, Sakano H, Takemori T. Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage. J Exp Med. 2000.07; 192 (2): 171-182. ( PubMed )

  113. Yoshida T, Higuchi T, Hagiyama H, Strasser A, Nishioka K, Tsubata T. Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice. Int Immunol. 2000.04; 12 (4): 517-526. ( PubMed )

  114. Adachi T, Wakabayashi C, Nakayama T, Yakura H, Tsubata T. CD72 negatively regulates signaling through the antigen receptor of B cells. J Immunol. 2000.02; 164 (3): 1223-1229. ( PubMed )

  115. Tsubata T, Honjo T. B cell tolerance and autoimmunity. Rev Immunogenet. 2000; 2 (1): 18-25. ( PubMed )

  116. Hagiyama H, Adachi T, Yoshida T, Nomura T, Miyasaka N, Honjo T, Tsubata T. Signaling through the antigen receptor of B lymphocytes activates a p53-independent pathway of c-Myc-induced apoptosis ONCOGENE. 1999.07; 18 (28): 4091-4098.

  117. Tsubata T. Co-receptors on B lymphocytes. Curr Opin Immunol. 1999.06; 11 (3): 249-255. ( PubMed )

  118. Tsubata T. Apotosis of mature B cells. Int Rev Immunol. 1999; 18 (4): 347-365. ( PubMed )

  119. Watanabe N, Nomura T, Takai T, Chiba T, Honjo T, Tsubata T. Antigen receptor cross-linking by anti-immunoglobulin antibodies coupled to cell surface membrane induces rapid apoptosis of normal spleen B cells SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1998.06; 47 (6): 541-547.

  120. Adachi T, Flaswinkel H, Yakura H, Reth M, Tsubata T. Cutting edge: The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation JOURNAL OF IMMUNOLOGY. 1998.05; 160 (10): 4662-4665.

  121. Tsubata T. [Mechanisms for B cell tolerance and their defects in systemic autoimmune diseases] Nippon Rinsho. 1997.06; 55 (6): 1351-1355. ( PubMed )

  122. Tsubata T. [Regulatory mechanisms for B lymphocyte apoptosis] Seikagaku. 1997.05; 69 (5): 299-310. ( PubMed )

  123. Han H, Nomura T, Honjo T, Tsubata T. Involvement of the cyclin-dependent kinase inhibitor p27Kip1 in negative signaling through the antigen-receptor of B lymphocytes. Leukemia. 1997.04; 11 Suppl 3 367-369. ( PubMed )

  124. Tsubata T. Regulatory mechanisms for B lymphocyte apoptosis SEIKAGAKU. 1997; 69 (5): 299-310.

  125. Tsubata T. [Abnormality in B cell apoptosis in mice with spontaneous systemic autoimmune disease] Nihon Rinsho Meneki Gakkai Kaishi. 1996.12; 19 (6): 603-604. ( PubMed )

  126. Furukawa M, Sakamoto A, Kita Y, Ohishi Y, Matsumura R, Tsubata R, Tsubata T, Iwamoto I, Saito Y, Sumida T. T-cell receptor repertoire of infiltrating T cells in lachrymal glands, salivary glands and kidneys from alymphoplasia (aly) mutant mice: a new model for Sjogren's syndrome. Br J Rheumatol. 1996.12; 35 (12): 1223-1230. ( PubMed )

  127. Tsubata R, Tsubata T, Hiai H, Shinkura R, Matsumura R, Sumida T, Miyawaki S, Ishida H, Kumagai S, Nakao K, Honjo T. Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sjogren's syndrome. Eur J Immunol. 1996.11; 26 (11): 2742-2748. ( PubMed )

  128. Han H, Nomura T, Honjo T, Tsubata T. Differential modulation of cyclin-dependent kinase inhibitor p27Kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40. Eur J Immunol. 1996.10; 26 (10): 2425-2432. ( PubMed )

  129. Han H, Nomura T, Honjo T, Tsubata T. Differential modulation of cyclin-dependent kinase inhibitor p27(Kip1) by negative signaling via the antigen receptor of B cells and positive signaling via CD40 EUROPEAN JOURNAL OF IMMUNOLOGY. 1996.10; 26 (10): 2425-2432.

  130. Shinkura R, Matsuda F, Sakiyama T, Tsubata T, Hiai H, Paumen M, Miyawaki S, Honjo T. Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice. Int Immunol. 1996.07; 8 (7): 1067-1075. ( PubMed )

  131. Nomura T, Han H, Howard MC, Yagita H, Yakura H, Honjo T, Tsubata T. Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice. Int Immunol. 1996.06; 8 (6): 867-875. ( PubMed )

  132. Agata Y, Kawasaki A, Nishimura H, Ishida Y, Tsubata T, Yagita H, Honjo T. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol. 1996.05; 8 (5): 765-772. ( PubMed )

  133. Nisitani S, Tsubata T, Murakami M, Honjo T. Administration of interleukin-5 or -10 activates peritoneal B-1 cells and induces autoimmune hemolytic anemia in anti-erythrocyte autoantibody-transgenic mice. Eur J Immunol. 1995.11; 25 (11): 3047-3052. ( PubMed )

  134. NISITANI S, TSUBATA T, MURAKAMI M, HONJO T. ADMINISTRATION OF INTERLEUKIN-5 OR INTERLEUKIN-10 ACTIVATES PERITONEAL B-1 CELLS AND INDUCES AUTOIMMUNE HEMOLYTIC-ANEMIA IN ANTIERYTHROCYTE AUTOANTIBODY-TRANSGENIC MICE EUROPEAN JOURNAL OF IMMUNOLOGY. 1995.11; 25 (11): 3047-3052.

  135. Murakami M, Yoshioka H, Shirai T, Tsubata T, Honjo T. Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells. Int Immunol. 1995.05; 7 (5): 877-882. ( PubMed )

  136. Li H, Akamizu T, Okuda J, Sugawa H, Matsuda F, Tsubata T, Mori T. Isolation of Epstein-Barr-virus-transformed lymphocytes producing IgG class monoclonal antibodies using a magnetic cell separator (MACS): preparation of thyroid-stimulating IgG antibodies from patients with Graves' disease. Biochem Biophys Res Commun. 1995.02; 207 (3): 985-993. ( PubMed, DOI )

  137. LI H, AKAMIZU T, OKUDA J, SUGAWA H, MATSUDA F, TSUBATA T, MORI T. ISOLATION OF EPSTEIN-BARR-VIRUS-TRANSFORMED LYMPHOCYTES PRODUCING IGG CLASS MONOCLONAL-ANTIBODIES USING A MAGNETIC CELL SEPARATOR (MACS) - PREPARATION OF THYROID-STIMULATING IGG ANTIBODIES FROM PATIENTS WITH GRAVES-DISEASE BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1995.02; 207 (3): 985-993.

  138. Tsubata T, Nomura T, Nishitani S. [B lymphocyte antigen CD40 and its ligand, CD40L] Seikagaku. 1995.01; 67 (1): 51-55. ( PubMed )

  139. Tsubata T, Murakami M, Nisitani S, Honjo T. Molecular mechanisms for B lymphocyte selection: induction and regulation of antigen-receptor-mediated apoptosis of mature B cells in normal mice and their defect in autoimmunity-prone mice. Philos Trans R Soc Lond B Biol Sci. 1994.08; 345 (1313): 297-301. ( PubMed, DOI )

  140. TSUBATA T, MURAKAMI M, NISITANI S, HONJO T. MOLECULAR MECHANISMS FOR B-LYMPHOCYTE SELECTION - INDUCTION AND REGULATION OF ANTIGEN-RECEPTOR-MEDIATED APOPTOSIS OF MATURE B-CELLS IN NORMAL MICE AND THEIR DEFECT IN AUTOIMMUNITY-PRONE MICE PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES. 1994.08; 345 (1313): 297-301.

  141. Murakami M, Tsubata T, Shinkura R, Nisitani S, Okamoto M, Yoshioka H, Usui T, Miyawaki S, Honjo T. Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. J Exp Med. 1994.07; 180 (1): 111-121. ( PubMed )

  142. Nisitani S, Tsubata T, Honjo T. Lineage marker-negative lymphocyte precursors derived from embryonic stem cells in vitro differentiate into mature lymphocytes in vivo. Int Immunol. 1994.06; 6 (6): 909-916. ( PubMed )

  143. Tsubata T, Murakami M, Honjo T. Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice. Curr Biol. 1994.01; 4 (1): 8-17. ( PubMed )

  144. TSUBATA T, WU J, HONJO T. B-CELL APOPTOSIS INDUCED BY ANTIGEN RECEPTOR CROSS-LINKING IS BLOCKED BY T-CELL SIGNAL THROUGH CD40 JOURNAL OF CELLULAR BIOCHEMISTRY. 1994; 435.

  145. NISITANI S, TSUBATA T, MURAKAMI M, OKAMOTO M, HONJO T. THE BCL-2 GENE-PRODUCT INHIBITS CLONAL DELETION OF SELF-REACTIVE B-LYMPHOCYTES IN THE PERIPHERY BUT NOT IN THE BONE-MARROW JOURNAL OF EXPERIMENTAL MEDICINE. 1993.10; 178 (4): 1247-1254.

  146. TSUBATA T, WU J, HONJO T. B-CELL APOPTOSIS INDUCED BY ANTIGEN RECEPTOR CROSS-LINKING IS BLOCKED BY A T-CELL SIGNAL THROUGH CD40 NATURE. 1993.08; 364 (6438): 645-648.

  147. Hashimoto T, Amagai M, Ebihara T, Gamou S, Shimizu N, Tsubata T, Hasegawa A, Miki K, Nishikawa T. Further analyses of epitopes for human monoclonal anti-basement membrane zone antibodies produced by stable human hybridoma cell lines constructed with Epstein-Barr virus transformants. J Invest Dermatol. 1993.03; 100 (3): 310-315. ( PubMed )

  148. TSUBATA T, WU J, HONJO T. T-CELL-DERIVED COSTIMULATORY SIGNAL THROUGH THE CD40 MOLECULE RESCUES B-CELLS FROM SURFACE IMMUNOGLOBULIN-MEDIATED CELL-DEATH JOURNAL OF CELLULAR BIOCHEMISTRY. 1993.01; 215.

  149. Tsubata T, Tsubata R, Reth M. Crosslinking of the cell surface immunoglobulin (mu-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin kappa locus. Int Immunol. 1992.06; 4 (6): 637-641. ( PubMed )

  150. Murakami M, Tsubata T, Okamoto M, Shimizu A, Kumagai S, Imura H, Honjo T. Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature. 1992.05; 357 (6373): 77-80. ( PubMed, DOI )

  151. Okamoto M, Murakami M, Shimizu A, Ozaki S, Tsubata T, Kumagai S, Honjo T. A transgenic model of autoimmune hemolytic anemia. J Exp Med. 1992.01; 175 (1): 71-79. ( PubMed )

  152. Iwai K, Tsubata T, Katsura Y, Kumagai S, Imura H. Qualitative difference of anti-DNA antibody-producing cell precursors in the pre-immune B cell repertoire between normal and lupus-prone mice. Clin Exp Immunol. 1991.10; 86 (1): 106-111. ( PubMed )

  153. Tanaka M, Hashimoto T, Amagai M, Shimizu N, Ikeguchi N, Tsubata T, Hasegawa A, Miki K, Nishikawa T. Characterization of bullous pemphigoid antibodies by use of recombinant bullous pemphigoid antigen proteins. J Invest Dermatol. 1991.10; 97 (4): 725-728. ( PubMed )

  154. Tsubata T, Tsubata R, Reth M. Cell surface expression of the short immunoglobulin mu chain (D mu protein) in murine pre-B cells is differently regulated from that of the intact mu chain. Eur J Immunol. 1991.06; 21 (6): 1359-1363. ( PubMed )

  155. Tsubata T, Nishikawa S. Molecular and cellular aspects of early B-cell development. Curr Opin Immunol. 1991.04; 3 (2): 186-192. ( PubMed )

  156. Reth M, Wienands J, Tsubata T, Hombach J. Identification of components of the B cell antigen receptor complex. Adv Exp Med Biol. 1991; 292 207-214. ( PubMed )

  157. Tsubata T, Reth M. The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. J Exp Med. 1990.09; 172 (3): 973-976. ( PubMed )

  158. Hombach J, Tsubata T, Leclercq L, Stappert H, Reth M. Molecular components of the B-cell antigen receptor complex of the IgM class. Nature. 1990.02; 343 (6260): 760-762. ( PubMed, DOI )

  159. Kumagai S, Ishida H, Iwai K, Tsubata T, Umehara H, Ozaki S, Suginoshita T, Araya S, Imura H. Possible different mechanisms of B cell activation in systemic lupus erythematosus and rheumatoid arthritis: opposite expression of low-affinity receptors for IgE (CD23) on their peripheral B cells. Clin Exp Immunol. 1989.12; 78 (3): 348-353. ( PubMed )

  160. Tsubata T, Takahashi K. Limited proteolysis of bovine myelin basic protein by calcium-dependent proteinase from bovine spinal cord. J Biochem. 1989.01; 105 (1): 23-28. ( PubMed )

  161. Kinashi T, Inaba K, Tsubata T, Tashiro K, Palacios R, Honjo T. Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro. Proc Natl Acad Sci U S A. 1988.06; 85 (12): 4473-4477. ( PubMed )

  162. Tsubata T, Nishikawa S, Katsura Y, Kumagai S, Imura H. B cell repertoire for anti-DNA antibody in normal and lupus mice: differential expression of precursor cells for high and low affinity anti-DNA antibodies. Clin Exp Immunol. 1988.01; 71 (1): 50-55. ( PubMed )

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Books etc 【 display / non-display

  1. Alborzian Deh Sheikh, A., Akatsu, C. and Tsubata, T.. Identification of Siglec Cis-ligands by Proximity Labeling. In “Lectin Purification and Analysis: Methods and Protocols” ed. by Jun Hirabayashi. Springer, 2020 (ISBN : 978-1-0716-0430-4)

  2. Tsubata, T.. Involvement of reactive oxygen species (ROS) in BCR signaling as a second messenger. In “B Cells in Immunity and Tolerance” ed. by Ji-Yang Wang. Springer, 2020 (ISBN : 978-981-15-3531-4)

  3. Takeshi Tsubata. Development of Siglec Regulators. In “Glycoscience: Basic Science to Applications” (ed. by Naoyuki Taniguchi, Tamao Endo, Jun Hirabayashi, Shoko Nishihara, Kenji Kadomatsu, Kazunari Akiyoshi and Kiyoko F. Aoki-Kinoshita). Springer, 2019.09 (ISBN : 9811358559)

  4. Siglec-2 is a key molecule for immune response. In “Experimental Glycoscience, Glycobiology” . Springer. , 2008

  5. Regulation of B cell antigen receptor signaling by CD72. In “Activating and Inhibitory Immunoglobulin-like Receptors”. Sprnger-Verlag Tokyo, 2001

  6. Molecular mechanisms for apoptosis induced by siganling through the B cell antigen receptor. . Int. Rev. Immunol., 20, 2001

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Conference Activities & Talks 【 display / non-display

  1. P. A. Koni., Ren, M., Tsubata, T., Khleif, S., Maverakis, E. and Shimoda, M.. A mouse model for chronic inflammatory diseases spontaneously develops CD4/CD8 double-positive T cell leukemia/lymphoma. . The 54th Midwinter Conference of Immunologists at Asilomar. 2015.01.24 Big Bear Lake, California (USA)

  2. Matsubara, N., Ishida, H. and Tsubata, T.. CD22-binding synthetic sialosides as a tool to elucidate the role of CD22 cis-ligand and as a novel immunostimulan. Medical Research Institute 40th Anniversary, 13th Surugadai International Symposium & Joint Usage/Research Program of Medical Research Institute International Symposium. 2014.11.28 Tokyo

  3. Matsubara, N., Takematsu, H., Ishida, H., Tsubata, T.. Role of CD22/Siglec2 and its ligand in B lymphocyte activation. . Joint annual meeting of SFG &JSCR, Integrating Glycoscience from Biology and Chemistry to Medicine. 2014.11.16 Honolulu, Hawaii (USA)

  4. Matsubara, N., Ishida, H. and Tsubata, T.. Synthetic sialosides that regulate CD22/Siglec-2, a B lymphocyte membrane molecule activating SH2-containing phosphatases.. 11th International Conference on Protein Phosphatase. 2014.11.12 Sendai

  5. Mohammad, A. and Tsubata, T.. Distinct tolerance mechanisms for anti-DNA and anti-Sm B cells. . Annual Meeting of the Japanese Society for Immunology 2013.12.11 Chiba.

  6. Xu. M., Hou. R., Sato-Hayashizaki. A., Man. R-Y., Zhu. C., Wakabayashi. C., Hirose. S., Adachi. T. and Tsubata. T.. Cd72c is a modifier gene that regulates Faslpr-induced autoimmune disease.. Annual Meeting of the Japanese Society for Immunology 2013.12.11 Chiba.

  7. Chizuru Akatsu, Quan-Zhen Li, Hideharu Sekine, Teizo Fujita, Takeshi Tsubata. CD72 inhibits lupus-specific B cell autoimmunity caused by response to apoptotic cells through recognition of lupus-specific self-antigens. The 50th Annual Meeting of the Japanese Society for Immunology 2021.12.09 Nara+WEB

  8. Kana Matsumura, Takeshi Tsubata. Persistence of antigens in endosome/lysosome is essential for B cell response to TI-2 polysaccharide antigens. The 50th Annual Meeting of the Japanese Society for Immunology 2021.12.09 Nara+WEB

  9. Takeshi Tsubata. Immunogenic Peptides Derived from SARS-CoV2. 19th Surugadai Symposium 2021.09.03 WEB

  10. N. Numoto, K. Hirata, C. Akatsu, T. Tsubata, N. Ito. Molecular mechanism of self-antigen recognition by the ligand binding domain of B cell inhibitory co-receptor CD72. 25TH Congress and General Assembly of the International Union of Crystallography 2021.08.14 WEB

  11. Amin Alborzian Deh Sheikh, Takeshi Tsubata, et al.. A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides. The 85th Annual Meeting of the Japanese Society of Interferon & Cytokine Research 2021.05.21 WEB

  12. Takeshi Tsubata. The SHP-1-activating inhibitory co-receptor CD22 paradoxically augments BCR signaling in immunodeficient B cells. The 14th International Conference on Protein Phosphatase 2020.12.10 Kobe + WEB

  13. Takeshi Tsubata. Regulation of B cells and autoimmune diseases. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.13 Hamamatsu, SHIZUOKA

  14. Kyoko Nishida, Akihiro Kimura, Takeshi Tsubata, Harumi Suzuki. The anti-oxidative enzyme NAD(P)H quinone oxidoreductase1 promotes Th17 cells differentiation by protecting oxidative stress. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

  15. Chizuru Akatsu, Quan-Zhen Li, Hideharu Sekine, Teizo Fujita, Takeshi Tsubata. The inhibitory B cell co-receptor CD72 recognizes various lupus self-antigens including C1q and inhibits B cell responses to these self-antigen . The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

  16. Yang-Yang Feng, Jun Liu, Ji-Yang Wang, Takeshi Tsubata . Essential role of late redoxosome in BCR ligation-induced B cell activation. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

  17. Ying Wang, Jun Liu, Ermeng Xiong, Chizuru Akatsu, Takeshi Tsubata, Ji-Yang Wang. LAPTM5 mediates anti-IgM-induced apoptosis in immature B cells. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

  18. Liu, J., Qian, J., Xiong, E., Zhang, L., Wang, Y., Chu, Y., Tsubata, T. and Wang, J.-Y.. Role of the IgM Fc receptor in marginal zone B cell development and function. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

  19. Tang, Y., Lai, N., Xiong, E., Ouchida, R., Sun, J., Hikida, M., Tsubata, T., Wang, Y. and Wang, J.-Y.. Distinct roles of B cell novel protein 1 in B cell development and activation. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

  20. Xiong, E., Cui, C., Min, Q., Liu, J., Lai, N., Wang, Y., Matsumoto, R., Takahashi, D., Hase, K., Shinkura, R., Tsubata, T. and Wang, J.-Y.. MZB1 promotes the secretion of J chain-containing IgA and is critical for the suppression of gut inflammation. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

  21. Takeshi Tsubata. Regulation of the immune response to nucleic acids and systemic lupuserythematosus. The 1st “Wuxi talents” Symposium of Experimental Research Center of the First People’s Hospital of Huaihua 2019.11.29 Huaihua, CHINA

  22. Takeshi Tsubata. SHP-1 (PTPN6) regulates development of SLE through CD72. The 4th Taiwan-Japan Bilateral Conference on Protein Phosphatase 2019.11.15 Taipei,TAIWAN

  23. Takeshi Tsubata. Inhibitory B cell co-receptors and autoimmune diseases. Mini-symposium on Protein Structure and Function 2019.10.03 Taipei,TAIWAN

  24. YangYang Feng, Miao Tang, Mitsuhiro Suzuki, Chinthika Gunasekara, Yuki Anbe, Yuichi Hiraoka, Jun Liu, JiYang Wang, Takeshi Tsubata. Essential role of NOX3-mediated endosomal production of ROS in maintenance of sustained B cell receptor signaling and B cell proliferation. The 92nd Annual Meeting of the Japanese Biochemical Society 2019.09.18 Yokohama, KANAGAWA

  25. Yang-Yang Feng, Miao Tang, Mitsuhiro Suzuki, Chinthika Gunasekara, Yuki Anbe, Yuichi Hiraoka, Jun Liu, Helmut Grasberger, Mamoru Ohkita, Yasuo Matsumura, Ji-Yang Wang, and Takeshi Tsubata. Essential role of NADPH oxidase-dependent production of reactive oxygen species in maintenance of sustained B cell receptor signaling and B cell proliferation. The 28th Annual Meeting of the Japanese Society for Cell Death Research 2019.07.13 TOKYO

  26. Long Wang、Endo Ayaka、Takematsu Hiromu、Fedder Thomas、Tsubata Takeshi. Development of anti-CD22 antibody that inhibits ligand binding of CD22. The Regular Meeting of the Japanese Biochemical Society Kanto Branch 2019.06.22 Yokohama, KANAGAWA

  27. Kyoko Nishida, Akihiro Kimura, Takeshi Tsubata, Harumi Suzuki. NQO1 regulates pathogenisity of Th17 cells by suppressing IL-10 production. The 47th Annual Meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

  28. Chizuru Akatsu, Xuexin Li, Susumu Kusunoki, Takeshi Tsuabta. SHP-1-activating B lymphocyte co-receptors and autoimmune diseases. The 47th Annual Meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

  29. Chizuru Akatsu, Quan-Zhen Li, and Takeshi Tsubata. Roles of CD72 in the regulation of autoantibody production and type 1 interferon production in autoimmune disease. The 47th Annual Meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

  30. Xuexin Li, Soha Gomaa Ramadan Abdel Salam, Matthew Routledge, Yuki Hitomi, Susumu Kusunoki, Takeshi Tsubata. Significant associations of human SIGLEC10 polymorphisms with susceptibility to Guillain-Barré syndrome. The 47th Annual Meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

  31. Yangyang Feng, Jun Liu, Helmut Grasberger, Ji-Yang Wang, Takeshi Tsubata. Essential role of NADPH oxidase-dependent production of reactive oxygen species in maintenance of sustained B cell receptor signaling and B cell proliferation . The 47th Annual Meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

  32. Takeshi Tsuabta. Ligand recognition determines functional properties of inhibitory B cell co-receptors. International Symposium on B cells 2018.12.07 Shanghai,China

  33. Chinthika Gunasekara、Kozo Watanabe、Takeshi Tsubata. Reactive oxygen species play a role in endosomal B cell antigen receptor signaling. 7th Federation of Immunological Societies of Asia-Oceania (FIMSA) Congress 2018 2018.11.10 Bangkok,Thailand

  34. Chizuru Akatsu, Xuexin Li, Susumu Kusunoki, Takeshi Tsuabta. SHP-1-activating B lymphocyte co-receptors and autoimmune diseases. Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13) 2018.10.23 Tokyo

  35. Yang-Yang Feng, Miao Tang, Mitsuhiro Suzuki, Jun Liu, Helmut Grasberger, Ji-Yang Wang and Takeshi Tsubata. Essential role of NADPH oxidases in BCR signaling and B cell proliferation. Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13) 2018.10.23 Tokyo

  36. Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata. The role of ligand recognition of SHP-1 activating receptor CD22 in the regulation of B cell tonic signaling. Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13) 2018.10.23 Tokyo

  37. Moe Endo, Chizuru Akatsu, Quan-Zhen Li, Chengsong Zhu, Teizo Fujita, Hideharu Sekine, Takeshi Tsubata. Ligand recognition of the SHP-1-activating inhibitory B cell co-receptor CD72. Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13) 2018.10.23 Tokyo

  38. Takeshi Tsubata. Essential role of NADPH oxidase-dependent production of reactive oxygen species in maintenance of sustained B cell receptor signaling and B cell proliferation. 2018.06.25 Freiburg, Germany

  39. Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata. The role of CD22 glycan cis-ligands in the regulation of B cell tonic signaling. The Regular Meeting of the Japanese Biochemical Society Kanto Branch 2018.06.23 Saitama

  40. Yang-Yang Feng, Miao Tang, Mitsuhiro Suzuki, Jun Liu, Helmut Grasberger, Mamoru Ohkita, Yasuo Matsumura, Ji-Yang Wang, and Takeshi Tsubata. Role of NADPH oxidases in BCR signaling and B cell proliferation. The Regular Meeting of the Japanese Biochemical Society Kanto Branchranch 2018.06.23 Saitama

  41. Takeshi Tsubata. The Inhibitory B Cell Co-Receptor CD72 Regulates Tolerance to Self Nucleic Acids Crucial for Development of Systemic Lupus Erythematosus. Keystone Symposia, B cells: Mechanisms in Immunity and Autoimmunity 2018.06.21 Dresden, Germany

  42. Takeshi Tsubata. Endogenous ligands of inhibitory B cell co-receptors. 2018.06.15 Berlin, Germany

  43. Takeshi Tsubata. Endogenous ligands of inhibitory B lymphocyte co-receptors. 2018.06.14 Zürich, Switzerland

  44. Takeshi Tsubata. Inhibitory B cell co-receptors and autoimmune diseases. 45th IMSUT Founding Commemorative Symposium "A new era of medical researches created by disease models" 2018.06.01 Tokyo

  45. Feng Yangyang, Rengarajan Sundararaman, Tang Miao, Tsubata Takeshi. Role of NADPH oxidases in BCR ligation-induced ROS production and activation. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai

  46. MEDZHIDOV Nazim, TAKATA Toshitaro, SUZUKI Mitsuhiro, ICHINOSE Shizuko, YAMAGUCHI Hirofumi, ARAKAWA Satoko, SHIMIZU Shigeomi, TSUBATA Takeshi.. Role of poor B cell receptor ubiquitination in efficient antigen presentation. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai

  47. Takeshi Tsubata, Hongrui Yang, Chizuru Akatsu. CD72 recognizes RNA-related self-antigens and prevents autoimmunity. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai

  48. Kyoko Nishida, Akihiro Kimura, Takeshi Tsubata, Harumi Suzuki. NQO1 play a pathogenic role in autoimmune diseases through the suppression of IL-10 production in Th17 cells. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai

  49. Chizuru Akatsu, Amin Alborzian Deh Sheikh, Takeshi Tsubata. Role of CD45 (PTPRC) in the regulation of SHP-1 (PTPN6)-activating receptor CD22. The 3rd Japan-Taiwan Bilateral Conference on Protein Phosphatase 2017.11.19 Sendai

  50. Chizuru Akatsu, Hongrui Yang and Takeshi Tsubata,. The Inhibitory B Cell Co-Receptor CD72 Regulates B Cell Response to Self Nucleic Acids Crucial for Development of SLE. Korean Association of Immunologists (KAI) International Meeting 2017 2017.11.10 Seoul

  51. Takeshi Tsubata. Inhibitory B cell co-receptor and autoimmunity. Seoul National University School of Dentistry 2017.11.08 Seoul

  52. Takeshi Tsubata. Inhibitory B cell co-receptor CD72 regulates self-tolerance through SHP-1 activation. University of Freiburg 2017.10.11 Freiburg, Germany

  53. Nobutaka Numoto,Chizuru Akatsu,Kenro Shinagawa,Takeshi Tsubata,Nobutoshi Ito. Charge distribution regulates the ligand-binding affinity of B cell inhibitory receptor CD72. The 55th Annual Meeting of the Biophysical Society of Japan 2017.09.20 Kumamoto

  54. Feng Yangyang, Rengarajan Sundararaman, Tang Miao, Tsubata Takeshi. Role of prolonged ROS in B cell receptor signaling. The Regular Meeting of the Japanese Biochemical Society, Kanto Branch 2017 2017.06.17 Tokyo

  55. MEDZHIDOV Nazim, TAKATA Toshitaro, SUZUKI Mitsuhiro, ICHINOSE Shizuko, TSUBATA Takeshi. Distinct ubiquitination level and sorting of the B cell receptor. The Regular Meeting of the Japanese Biochemical Society, Kanto Branch 2017 2017.06.17 Tokyo

  56. Amin Alborzian-Deh-Sheikh, Chizuru Akatsu, Hideharu Ishida2, and Takeshi Tsubata. Cis-ligand dependent and independent interaction of receptor type protein tyrosine phosphatase CD45 with B cell inhibitory receptor CD22. The Regular Meeting of the Japanese Biochemical Society, Kanto Branch 2017 2017.06.17 Tokyo

  57. Mohammad Aslam, Martin Weigert and Takeshi Tsubata. Regulation of self-reactive B cells by CD72 and Fas . 11th International Symposium of The Institute Network"Frontiers in Biomedical Sciences" 2017.01.26 Tokushima

  58. Medzhidov Nazim, Takata toshitaro, Suzuki Mitsuhiro, Ichinose Shizuko, Tsubata Takeshi. Distinct ubiquitination level and sorting of B cell receptor. The 45th Annual Meeting of The Japanese Society for Immunology (JSI) 2016.12.06 OKINAWA

  59. Takeshi Tsubata. Development of a novel glycomimetic with unique immunological activity. . 15th Surugadai International Symposium "Current Status and Future of Drug Discovery" 2016.11.29 TOKYO

  60. Takeshi Tsubata. B lymphocytes and autoimmunity. Fudan University School of Basic Medical Sciences, China 2016.11.07 SHANGHAI,CHINA

  61. Chizuru Akatsu,Kenro Shinagawa, Nobutaka Numoto, Zhihong Liu, Mohommad Aslam, Nobutoshi Ito, Takeshi Tsubata. B cells reactive to Sm/RNP, a lupus-related self-antigen. 12th International Conference on Protein Phosphatase (ICPP12) 2016.10.28 OSAKA

  62. Tsubata, T.. B lymphocyte co-receptors and systemic lupus erythematosis. Fudan University 2015.12.16 Shainghai

  63. Akatsu, C., Aslam, M., Adachi, T. and Tsubata, T.. Interaction of CD72 and SLE-related antigen negatively regulates self-reactive B cells. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.20 Sapporo

  64. Aslam, M., Adachi, T. and Tsubata, T.. CD72 regulates self-reactive B cells to nuclear antigens. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.20 Sapporo

  65. Onodera, T., Adachi, T., Tsubata, T., Ato, M. and Takahashi, Y.. Visualization of anti-nuclear Ab producing B cells by flow-cytometry in a SLE mouse model. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.18 Sapporo

  66. Aslam, M., Adachi, T., Weigert, M. G. and Tsubata, T.. CD72 regulates self-reactive B cells to nuclear antigens. The 30th Autoimmune Conference 2015.07.11 Tokyo

  67. Tsubata, T.. CD22-binding synthetic sialosides as a tool to elucidate the role of CD22 cis-ligand and as a novel immunostimulant. 2015.03.23 Freiburg

  68. Tsubata, T.. CD22-binding synthetic sialosides as a tool to elucidate the role of CD22 cis-ligand and as a novel immunostimulant. TRR130 2015.03.18 Erlangen

  69. Tsubata, T.. CD22-binding synthetic sialosides as a tool to elucidate the role of CD22 cis-ligand and as a novel immunostimulant. DRFZ 2015.03.16 Berlin

  70. Li, Y., Hase, K., Tsubata, T. and Wang, J-Y.. Glia maturation factor-γ regulates marginal zone B cell migration and humoral immune responses.. Annual Meeting of the Japanese Society for Immunology 2013.12.11 Chiba.

  71. Tsubata, T.. Regulation of B lymphocyte responses and sialic acid-binding immunoglobulin-like lectins (Siglecs). . Glyco Medicine Seminar, IBMS, Academia Sinica, 2013.11.27 Taipei.

  72. Tsubata, T.. SHP-1-activating Receptors in B lymphocytes. . The 2nd Taiwan-Japan Bilateral Conference on Protein Phosphatase 2013.11.27 Hsinchu.

  73. Tsubata, T.. Sialic acids and immune responses. Molecular Frontier Science Conference for Humboltians and DAAD Alumni 2013.09.20 上海

  74. Shimoda. M., Bolduc. A., Takezaki. M., Tsubata. T. and Koni. P-A. . Excess B cell CD40/CD40L signaling promotes CD4 T cell-mediated encephalomyelitis in mice. . Immunology 2013 AAI Annual meeting. 2013.05.03 Honolulu.

  75. Tsubata, T.. CD72c a hapolotype encoding the SHP-1-binding B lymphocyte molecule is a modifier gene for murine lupus. the 10th International Conference on Protein Phosphatase 2013.02.07 東京

  76. Tsubata, T.. CD72C , a hapolotype encoding the SHP-1-binding B lymphocyte molecule, is a modifier gene for murine lupus. the 10th International Conference on Protein Phosphatase 2013.02.07 東京

  77. Tang, M., Takata, T., Tsubata, T.. Time, place and pathway-specific involvement of reactive oxygen species in B cell antigen receptor signaling. . 日本免疫学会学術総会 2013.02.05 神戸

  78. Suganuma, Y., Matsubara, N., Iwayama, Y., Ueki, A., Imamura, A., Ando, H., Tsubata, T., Ishida, H. and Kiso, M.. Synthesis and biological evaluation of the mimics of cis ligand for CD22. The 4th Asian Communication for Glycobiology and Glycotechnology (ACGG) 2012.10.28 Jeju, Korea

  79. Tsubata, T.. Screening of chemical compounds that regulate antibody responses. . 中国医学科学院/北京協和医科大学 2012.03.14 北京、中国

  80. Tsubata, T.. Molecular and Cellular aspects of Autoimmune Diseases. . 中国医科大学 2012.01.09 瀋陽、中国

  81. Tang Miao、高田俊太朗、鍔田武志. Role of Reactive Oxygen Species in B Cell Antigen Receptor Signaling. 第40回日本免疫学会学術集会 2011.11.27 幕張

  82. Tsubata, T.. Development of chemial compounds that regulate specific antibody production.. 中国医学科学院/北京協和医科大学 2011.03.17 北京、中国

  83. Tsubata, T.. Apoptotic deletion of self-reactive B cells in the splenic marginal zone. . The Gwen Knapp Symposium “the Antigen Targets of Autoimmune Disease”, The University of Chicago 2010.10.08 Chicago, USA.

  84. Tsubata, T.. Excess CD40L and autoimmunity.. Immunotherapy Center, Medical College of Georgia 2010.10.06 Augusta, USA.

  85. Tsubata, T.. Apoptotic deletion of marginal zone B cells: a novel tolerance mechanism of pathogenic self-reactive B cells.. Deutsches Rheuma-Forschungszentrum Berlin (DRFZ) 2010.10.04 Berlin, Germany.

  86. Tsubata, T.. Control of infectious diseases by functional modulation of B lymphocytes. . The 8th German-Japanese Immunology Symposium ”Regulation of Immune Response and Disease” 2010.09.26 Cuxhaven, Germany.

  87. Tsubata, T.. Membrane-bound lectins and humoral immunity. International Summer Program 2010 ”Infection and Immunity”, Tokyo Medical and Dental University 2010.09.05 Tokyo.

  88. Hou, R., Sato, A., Lin, Q., Ohtsuji, M., Adachi, T., Hirose, S., Tsubata, T.. Effect of CD72c allotype on SLE susceptibility.. 15th International Congress of Immunology 2010.08.22 Kobe

  89. Kishi, Y., Higuchi, T., Sakamaki, Y., Tsubata, T.. Overexpression of CD40L (CD154) breaks down self-tolerance in spleen in autoantibody-transgenic mice. . 14th International Congress of Immunology 2010.08.22 Kobe

  90. Man, R.-Y., Onodera, T., Komatsu, E., Tsubata, T.. Augmented B Lymphocyte Response to Antigen in the Absence of Antigen-Induced B lymphocyte Signaling in an IgG-Transgenic Mouse Line. . 14th International Congress of Immunology 2010.08.22 Kobe

  91. Abdu-Allah, H. H. M., Ishida, H., Tsubata, T., Kelm, S., Paulson, J. C., Ando, H., Kiso, M.. Design and Synthesis of Novel Sialosides as potent and selective CD22-Inhibitors. . Sialoglyco Meeting 2010 2010.08.21 Potsdam, Germany.

  92. Tsuiji. M., Tanaka. M., Imai. N., Hayashizaki. K., Tsubata. T.. The Immune Response against Capsular Polysaccharides of Streptococcus pneumoniae. . The 28th Naito Conference on ”Glycan Expression and Regulation [I]:Functions and Disease Mechanisms” 2010.07.27 Kanagawa.

  93. Tsubata, T.. Control of Infectious Diseases by Functional Modulation of B Lymphocyte Lectins. . The 28th Naito Conference on ”Glycan Expression and Regulation [I]:Functions and Disease Mechanisms” 2010.07.27 Kanagawa.

  94. Miduo Xu, Rong Hou, Mareki Ohtsuji, Naomi Ohtsuji, Takahiro Adachi, Sachiko Hirose, Takeshi Tsubata. CD72 modulates the development of lupus-like disease in B61pr/pr mice. 第39回日本免疫学会 2009.12.02 大阪

  95. Rong Hou, Mareki Ohtsuji, Naommi Ohtsuji, Li Zhang, Takahiro Adachi, Sachiko Hirose, Takeshi Tsubata. Centromeric interval of chromosome4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72b congenic mice. 第39回日本免疫学会 2009.12.02 大阪

  96. Man Rong-Yong, Taishi Onodera, Takeshi Tsubata. Ligand-independent high tonic signaling through IgG-BCR induces B-cell receptor signaling defect and enhances B cell response. 第39回日本免疫学会 2009.12.02 大阪

  97. 満栄勇、小野寺大志、鍔田武志. Increased tonic B cell antigen receptor signaling but reduced antigen-induced B cell response in transgenic B cells expressing IgG. 第38回日本免疫学会総会・学術集会 2009.12.01 京都

  98. Tsubata, T.. B cell response augmentation by expression of IgG and deficiency in CD22. Annual Symposium of the Korean Association of Immunologists 2009.11.09 Seoul, Korea

  99. Tsubata, T.. Inhibitory B lymphocyte co-receptor CD72 and autoimmunity. C. M. U. (ジュネーブ大学医療センター) 2009.09.18 Geneva, Switzerland

  100. N. Engels, L. M. Koening, C. Heemann, J. Lutz, Tsubata, T., S.Griep, V. Schrader, J. Wienands. The immunoglobulin tail tyrosine of surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells. 2ndEuropean Congress of Immunology 2009.09.13 Berlin, Germany

  101. Tsubata, T.. Membrane-bound lectins and humoral immunity. 2ndEuropean Congress of Immunology 2009.09.13 Berlin, Germany

  102. Tsubata, T.. How unresponse, slow response and rapid response of humoral immunity is determined? . ZIBI International Summer School on Pathogen-Host-Interplay 2009.07.19 Berlin, Germany

  103. Tsubata, T.. Membrane-bound lectins and humoral immunity. CREST International Symposium “Acquired Immunity and Glycobiology” 2009.03.23 Kazusa, Japan

  104. Wtanabe, K., Tsuchiya, Y., Kawaguchi, Y., Ayame, H., sawada, S., Akiyoshi, K., Tsubata, T.. Self-assembled cationic nanogel-mediated efficient protein delivery in mouse primary T cells. The 5th international Workshop of Kyoto Tcell conference 2009.01.01 Kyoto, Japan

  105. Tsubata, T.. Molecular and cellular aspects of antibody production and its abnormality. China Medical University 2008.11.27 Shenyang, China

  106. Tsubata, T.. Cell death, autophagy, cell senescence and their roles in diseases. 7th Surugadai International Symposium 2008.11.16 Tokyo

  107. Tsubata, T.. Endoplasmic reticulum stress and autoimmune diseases. Kongress der Deutschen Gesellschaft fur Rheumatologie 2008.09.24 Berlin, Germany

  108. Tsubata, T.. Regulation of the B cell response by BCR and its co-receptors: Idling BCR engine model. Georg August University of Goettingen 2008.09.23 Goettingen, Germany

  109. Tsubata, T.. Regulation of the B cell response by BCR and its co-receptors: Idling BCR engine model. Nikolaus Fiebiger Centre for Molecular Medicine, University of Erlangen-Nurnberg 2008.09.17 Erlangen, Germany,

  110. Tsubata, T.. Regulation of the time course of B cell response by BCR and its co-receptors. Deutsches Rheuma-Forschungszentrum 2008.09.01 Berlin, Germany,

  111. Tsubata, T.. Regulation of the B cell response by BCR and its co-receptors. MPI Immunobiology 2008.08.25 Freiburg, Germany,

  112. Tsubata, T.. Functional role of inhibitory BCR co-receptors CD22 and CD72. 1st International Singapore symposium of immunology 2008.01.14 Singapore

  113. Zhu, C., Adachi, T., Sato, M., Fujimoto, M., Tsubata, T. . An ITAM-like motif containing tyrosine 817 in CD22 together with an ITIM containing tyrosine 783 is sufficient for negative regulation of BCR signaling. . 第37回日本免疫学会総会・学術集会 2007.11.20 東京

  114. Yu, J., Adachi, T., Gao, X., Takematsu, H., Tsubata, T. . 合成糖鎖リガンドによるCD22のB細胞受容体とのリピッドラフトでの共局在の阻害/ Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts. . 第37回日本免疫学会総会・学術集会 2007.11.20 東京

  115. Yan, B., Adachi, T., Tsubata, T.. 小胞体ストレスがB細胞抗原受容体を介したアポトーシスに関与する/ Unfolded protein response is involved in B cell antgen receptor-mediated apoptosis.. 第37回日本免疫学会総会・学術集会 2007.11.20 東京

  116. Mohamed, A, A, H, H., Tsubata, T., Ishida, H. and Kiso, M. . Design and synthesis of novel sialosides as potential CD22-specific inhibitors. . XIX International Symposium on Glycoconjugates. (Glyco-19) 2007.07.15 Cairns, Australia.

  117. Yu, J. and Tsubata, T.. 糖鎖リガンド類似化合物によるBリンパ球活性化制御分子CD22の機能制御. 日本ケミカルバイオロジー研究会第2回年会 2007.05.09 京都

  118. A, A, H, H, Mohamed., Tsubata, T., Ishida, H. and Kiso, M.. Design and synthesis of novel sialosides as potential CD22-specific inhibitors. . The 2nd Annual meeting of Japanese society for chemical biology 2007.05.09 Kyoto

  119. Tsubata, T.. Functional role of inhibitory BCR Co-receptors CD22 and CD72. . 1st International Singapore Symposium of Immunology. 2007.01.12 Biopolis, Singapore.

  120. Yu J, Adachi T, Gao X, Tsubata T.. Establishment of the screening for mouse CD22 inhibitors. . 第36回日本免疫学会総会学術集会 2006.12.11 大阪

  121. 厳斌成、安達貴弘、鍔田武志. B細胞抗原受容体を介したアポトーシスにおけるROSの役割. 第36回日本免疫学会総会学術集会 2006.12.11 大阪

  122. Zhu C, Sato M, Fujimoto M and Tsubata T. . The signal immunoreceptor tyrosine-based inhibition motif containing the tyrosine 783 in CD22 is sufficient for negative regulation of BCR signaling.. 第36回日本免疫学会総会学術集会 2006.12.11 大阪

  123. Tsubata, T.. Immunoglobulin isotype-dependent regulation of B cell antigen receptor signaling mediated by Siglec2/CD22. . The 5th Sialoglycoscience 2006 International Conference 2006.08.27 Mishima

  124. Zhu C, Tsubata T and Adachi T. . The single immunoreceptor tyrosine-based inhibition motif surrounding the tyrosine 783 in CD22 (siglec2) is sufficient for negative regulation of BCR signaling.. 20th IUBMB International Congless of Biochemistry and Molecular Biology and 11th FAOBMB Congress. 2006.06.18 Kyoto

  125. Toda M, Takeuchi N, Inoue M, Adachi T, Matsubara J, Taketani S, Tsubata T, Murata T and Nakada H.. Immunosuppressive effect of mucin on B cell function in tumor-bearing state. . 20th IUBMB International Congless of Biochemistry and Molecular Biology and 11th FAOBMB Congress. 2006.06.18 Kyoto

  126. 于潔、澤田敏彦、安達貴弘、Xiaoming Gao, 石田秀治、木曾真、鍔田武志. マウスCD22阻害剤のスクリーニング系の構築. 日本ケミカルバイオロジー研究会第一回年会 2006.05.08 東京

  127. 厳斌成、安達貴弘、鍔田武志. B細胞抗原受容体を介したアポトーシスにおけるROSの解析. 日本ケミカルバイオロジー研究会第一回年会 2006.05.08 東京

  128. Tsubata, T.. B cell tolerance and autoimmunity. . FIMSA/IIS Advanced Course on Immunology 2006.03.01 New Delhi, India

  129. Adachi, T., Bin-Cheng Yan., Tsubata, T.. Screening of the genes related to the cell cycle arrest-induced apoptosis. . International Symposium on Life of Proteins 2005.10.30 Awajishi

  130. Tsubata, T.. Cell cycle control of lymphocyte apoptosis. . Conference on “Cell Death, Cell Cycle and Cell Senescence” 2004.11.17 Kisarazu,

  131. Tsubata, T.. Molecular switches regulating activation of naive and memory B lymphocytes. The Japan-China Cooperative Life Science Symposium in Kumamoto 2004.11.12 Kumamoto

  132. Tsubata, T.. Molecular switches governing activation of naive and memory B lymphocytes.. National Center for AIDS/STD Control and Prevention (NCAIDS) 2004.09.22 Beijing

  133. 鍔田武志. Molecular switches determining activation vs. apoptosis of antigen-stimulated B lymphocytes. 理化学研究所和光本所 2004.09.02 和光市

  134. Tsubata, T.. Isotype-specific regulation of B lymphocyte activation by siglec 2/CD22.. 21st International Lectin Meeting 2004.05.23 Shonan

  135. Tsubata, T.. The level of c-Myc determines survival vs. apoptosis upon cell cycling.. UK-Japan Cell Cycle Workshop 2004.05.13 Nara

  136. Tsubata, T.. From BCR signal regulation to better vaccination strategies. . China-Japan Planning Meeting for Cooperative Study on SARS 2004.02.21 Tokyo

  137. Adachi, T., Hokazono, Y., Matthias Wabl, Tsubata, T.. Inhibitory co-receptors activated by antigens but not by Anti-immunoglobulin heavy chain antibodies Install requirement of co-stimulation through CD40 for survival and proliferation of B cells. Keystone Symposia 2004 “Lymphocyte activation and signaling” 2004.01.08 Steamboat Springs

  138. Tsubata, T.. Immunoglobulin isotype-specific regulation of B cell antigen receptor signaling.. Keystone Symposia 2004 “Lymphocyte activation and signaling” 2004.01.08 Steamboat Springs

  139. Tsubata, T.. Immunoglobulin isotype-specific regulation of B cell antigen receptor signaling. Keystone Symposia 2004.01.08 Steamboat Springs

  140. Tsubata, T.. Regulation of antigen receptor signaling in B lymphocytes –Towards understanding of the molecular basis of vaccination-. . Symposium “From Genome Science to Medicine” 2003.11.29 東京

  141. Tsubata, T.. Regulation of B lymphocyte activation by inhibitory BCR co-receptors CD22 and CD72. University of Bielefeld, 2003.11.11 Bielefeld

  142. Tsubata, T.. Immunoglobulin isotype-specific regulation of B cell antigen receptor signaling. . Joint Meeting of STS and FZI 2003.11.06 Weimar

  143. Tsubata, T.. Regulation of B lymphocyte activation by inhibitory BCR co-receptors CD22 and CD72. DRFZ 2003.11.04 Berlin

  144. Tsubata, T.. CD40 signaling perturbs peripheral deletion of self-reactive B cells.. Workshop on the Genetics and Mechanisms of Autoimmunity, Princeton 2003.03.21 Princeton

  145. 饗場祐一、樋口哲也、西岡清、鍔田武志. CD40リガンドの異所性発現による末梢B細胞トレランス破綻機構の解析 . 第36回日本免疫学会総会 2002.12.04 東京

  146. Y. Aiba, T. Higuch and T. Tsubata . Role of CD40 signaling in selection and maturation of B cells in vivo . 12th KTCC 2002.08.03 京都

  147. Tsubata ,T.. CD40 signaling abrogates clonal deletion of dsDNA-reactive B cells and induces lupus-like autoimmune disease.. The 7th International Workshop on Autoantibodies and Autoimmunity. 2001.09.26 Awaji

  148. Tsubata, T., Aiba, Y., Higuchi, T., Furukawa, k., Honjo, T.. CD40 signaling regulates selection of selfreactive B cells and maturation of gerninal center B cells in vivo. . 11th international congress of immunology. 2001.07.22 Stockholm,

  149. Tsubata ,T.. Regulation of self-reactive B cells by CD40 signaling.. 17th DGfI spring meeting. 2001.01.21 Innsbruck

  150. Tsubata, T.. Studies on B cell selection in CD40 ligand-transgenic mice.. South Florida University 2001.01.18 USA

  151. Tsubata, T.. Studies on B cell selection in CD40 ligand-transgenic mice.. Duke University 2001.01.17 USA

  152. Tsubata ,T., Higuchi,T., Aiba, Y., Honjo, T., and Martin Weigert. . Ectopic expression of CD40L on B cells abrogates self-tolerance and induces lupus-like autoimmune disease. . Keystone Symposia, Regulation of Immunity and Autoimminity. 2001.01.10 Keystone,

  153. Aiba, Y., Higuchi, T., Takamori, T., Honjo,T., and Tsubata, T.. Transgenic expression of CD40 ligand promotes maturation of germinal center B cells in vibvo. Keystone Symposia. Regulation of Immunity and Autoimminity. 2001.01.10 Keystone,

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Patents 【 display / non-display

  • Method for promoting immune response comprising inhibiting CD22 function in B cells

    Patent Number: US 9,018,245 B2

Awards & Honors 【 display / non-display

  • Best Presentation Award (Xuexin, Li),Japanese Society for Immunology,2018.12

  • Eugen-und-Ilse-Seibold-Preis, Eugen and Ilse Seibold Prize,Deutsche Forschungsgemeinschaft,2017.10

  • Phillip Franz von Siebold Prize,President of Federal Republic of Germany,2005

Others 【 display / non-display

  • Two-faced protein both inhibits and activates B cell receptor signaling,2022.04

    AAAS EurekAlert! The Global Source for Science News

  • A subtle change in the DNA may predispose to polyneuropathy after gut infection,2021.01

    AAAS EurekAlert! The Global Source for Science News

 

Performance of duties 【 display / non-display

  • ,1996.07 - Now

  • ,1991.05 - 1995.04

  • ,1987.06 - 1991.04

  • ,1986.05