Personnel Information



Job title


Laboratory Address

1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan

Mail Address

The inquiry by e-mail is 《here

Research Areas, Keywords

immune response, antibody, glycan antigens, autoimmunity, infection immunity, apoptosis, vesicular transport, ROS

Graduating School 【 display / non-display

  • Kyoto University, Faculty of Medicine, 1981, Graduated

Graduate School 【 display / non-display

  • Kyoto University, Graduate School, Division of Medicine, Doctor's Course, 1987, Completed

Degree 【 display / non-display

  • Doctor, Kyoto University

Campus Career 【 display / non-display

  • 1996.07
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Immunology, Professor
  • 2003.04
    Tokyo Medical and Dental University, Director
  • 2010.04
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Immunology, Professor
  • 2012.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Immunology, Professor
  • 2012.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Immunology, Professor

External Career 【 display / non-display

  • , Associate Professor
  • , Associate Professor

Research Areas 【 display / non-display

  • Immunology

  • General medical chemistry


Published Papers & Misc 【 display / non-display

  • 128. Alborzian Deh Sheikh, A, Akatsu, C., Abdu-Allah, H. H. M., Suganuma, Y., Imamura, A., Ando, H., Takematsu, H., Ishida, H. and Tsubata, T.. The protein tyrosine phosphatase SHP-1 (PTPN-6) but not CD45 (PTPR-C) is essential for the ligand-mediated regulation of CD22 in BCR-ligated B cells J. Immunol. 2021.06; 206 (11): 2544-2551. ( PubMed, DOI )

  • Ballet, R., Brennan, M., Brandl, C., Feng, N., Berri, J., Cheng, J., Ocón, B., Alborzian Deh Sheikh, A., Marki, A., Bi,Y., Abram, C. L., Lowell, C. A., Tsubata, T., Greenberg, H. B., Macauley, M. S., Ley, K., Nitschke, L., Butcher. E. C. A CD22-Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity Nature Immunology. 2021.02; 22 381-390.

  • Tsugawa, N., Yamada, D., Watabe, T., Onizawa, M., Wang, S., Nemoto, Y., Oshima, S., Tsubata, T., Adachi, T., Kawano, Y., Watanabe, M., Blumberg, RS., Okamoto, R., Nagaishi, T. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation. Biochemical and Biophysical Research Communications. 2021.01; 535 99-105. ( PubMed, DOI )

  • Alborzian Deh Sheikh, A., Gomaa, S., Li, X., Routledge, M., Saigoh, K., Numoto, N., Angata, T., Hitomi, Y., Takematsu, H., Tsuiji, M., Ito, N., Kusunoki, S., Tsubata, T. A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides. Journal of Autoimmunity. 2020.11; 116 102571. ( PubMed, DOI )

  • Alborzian Deh Sheikh, A., Akatsu, C. and Tsubata, T. . Identification of Siglec Cis-ligands by Proximity Labeling Methods. Mol. Biol. 2020.04; 2132 75-83. ( PubMed, DOI )

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Books etc 【 display / non-display

  • Alborzian Deh Sheikh, A., Akatsu, C. and Tsubata, T.. Identification of Siglec Cis-ligands by Proximity Labeling. In “Lectin Purification and Analysis: Methods and Protocols” ed. by Jun Hirabayashi. Springer, 2020 (ISBN : 978-1-0716-0430-4)

  • Tsubata, T.. Involvement of reactive oxygen species (ROS) in BCR signaling as a second messenger. In “B Cells in Immunity and Tolerance” ed. by Ji-Yang Wang. Springer, 2020 (ISBN : 978-981-15-3531-4)

  • Takeshi Tsubata. Development of Siglec Regulators. In “Glycoscience: Basic Science to Applications” (ed. by Naoyuki Taniguchi, Tamao Endo, Jun Hirabayashi, Shoko Nishihara, Kenji Kadomatsu, Kazunari Akiyoshi and Kiyoko F. Aoki-Kinoshita). Springer, 2019.09 (ISBN : 9811358559)

  • Siglec-2 is a key molecule for immune response. In “Experimental Glycoscience, Glycobiology” . Springer. , 2008

  • Regulation of B cell antigen receptor signaling by CD72. In “Activating and Inhibitory Immunoglobulin-like Receptors”. Sprnger-Verlag Tokyo, 2001

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Conference Activities & Talks 【 display / non-display

  • P. A. Koni., Ren, M., Tsubata, T., Khleif, S., Maverakis, E. and Shimoda, M.. A mouse model for chronic inflammatory diseases spontaneously develops CD4/CD8 double-positive T cell leukemia/lymphoma. . The 54th Midwinter Conference of Immunologists at Asilomar. 2015.01.24 Big Bear Lake, California (USA)

  • Matsubara, N., Ishida, H. and Tsubata, T.. CD22-binding synthetic sialosides as a tool to elucidate the role of CD22 cis-ligand and as a novel immunostimulan. Medical Research Institute 40th Anniversary, 13th Surugadai International Symposium & Joint Usage/Research Program of Medical Research Institute International Symposium. 2014.11.28 Tokyo

  • Matsubara, N., Takematsu, H., Ishida, H., Tsubata, T.. Role of CD22/Siglec2 and its ligand in B lymphocyte activation. . Joint annual meeting of SFG &JSCR, Integrating Glycoscience from Biology and Chemistry to Medicine. 2014.11.16 Honolulu, Hawaii (USA)

  • Matsubara, N., Ishida, H. and Tsubata, T.. Synthetic sialosides that regulate CD22/Siglec-2, a B lymphocyte membrane molecule activating SH2-containing phosphatases.. 11th International Conference on Protein Phosphatase. 2014.11.12 Sendai

  • Xu. M., Hou. R., Sato-Hayashizaki. A., Man. R-Y., Zhu. C., Wakabayashi. C., Hirose. S., Adachi. T. and Tsubata. T.. Cd72c is a modifier gene that regulates Faslpr-induced autoimmune disease.. Annual Meeting of the Japanese Society for Immunology 2013.12.11 Chiba.

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Patents 【 display / non-display

  • Method for promoting immune response comprising inhibiting CD22 function in B cells

    Patent Number: US 9,018,245 B2

Awards & Honors 【 display / non-display

  • Best Presentation Award (Xuexin, Li),Japanese Society for Immunology,2018.12

  • Eugen-und-Ilse-Seibold-Preis, Eugen and Ilse Seibold Prize,Deutsche Forschungsgemeinschaft,2017.10

  • Phillip Franz von Siebold Prize,President of Federal Republic of Germany,2005


Performance of duties 【 display / non-display

  • ,1996.07 - Now

  • ,1991.05 - 1995.04

  • ,1987.06 - 1991.04

  • ,1986.05