Personnel Information

写真a

ISHIKAWA Kinya


Job title

Professor

Laboratory Address

Yushima 1-5-45, Bunkyo-ku 113-8519, Tokyo, Japan.

Research Areas, Keywords

Personalized preventive medicine

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Graduating School 【 display / non-display 】

  • University of Tsukuba, School of Medicine, The University of Tsukuba, Medical School, 1989, Graduated

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Graduate School 【 display / non-display 】

  • University of Tsukuba, Graduate School, Division of Medicine, Doctor's Course, 1996, Completed

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Degree 【 display / non-display 】

  • Doctor of Medicine

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Campus Career 【 display / non-display 】

  • 2002.05
    -
    2014.12
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Junior Associate Professor
  • 2015.01
    -
    2016.02
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Professor
  • 1999.04
    -
    2017.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Central Clinical Facilities， Center for Personalized Medicine for Healthy Aging， Professor
  • 2017.04
    -
    2018.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Central Clinical Facilities， Center for Personalized Medicine for Healthy Aging， Professor
  • 2018.04
    -
    2021.09
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Central Clinical Facilities， Center for Personalized Medicine for Healthy Aging， Professor
  • 2018.04
    -
    Now
    Institute of Science Tokyo， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Advanced Therapeutic Sciences， Department of Personalized Genomic Medicine for Health， Professor
  • 2021.10
    -
    2023.10
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Integrated Facilities， Center for Personalized Medicine for Healthy Aging， Professor
  • 2023.11
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Advanced Therapeutic Sciences， Department of Personalized Genomic Medicine for Health， Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Advanced Therapeutic Sciences， Department of Personalized Genomic Medicine for Health， Professor

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Academic Society Affiliations 【 display / non-display 】

  • American Academy of Neurology, American Society of Human Genetics

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Research Areas 【 display / non-display 】

  • Personalized genomic medicine

  • Neurology

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Research Theme 【 display / non-display 】

  • Personalized genomic medicine, 2015.01 - Now

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Published Papers & Misc 【 display / non-display 】

  1. Takahashi S, Ono D, Shintaku H, Oyama J, Nishida Y, Ishikawa K, Yokota T. Cryptogenic New-onset Refractory Status Epilepticus with Hyperintensity of T1-weighted Magnetic Resonance Imaging in the Bilateral Basal Ganglia: An Autopsy Report. Internal medicine (Tokyo, Japan). 2024.09; ( PubMed, DOI )

  2. Chikada Ayaka, Orimo Kenta, Mitsui Jun, Matsukawa Takashi, Ishiura Hiroyuki, Toda Tatsushi, Mizusawa Hidehiro, Takahashi Yuji, Katsuno Masahisa, Hara Kazuhiro, Onodera Osamu, Ishihara Tomohiko, Tada Masayoshi, Kuwabara Satoshi, Sugiyama Atsuhiko, Yamanaka Yoshitaka, Takahashi Ryosuke, Sawamoto Nobukatsu, Sakato Yusuke, Ishimoto Tomoyuki, Hanajima Ritsuko, Watanabe Yasuhiro, Takigawa Hiroshi, Adachi Tadashi, Abe Koji, Yamashita Toru, Takashima Hiroshi, Higashi Keiko, Kira Junichi, Yabe Ichiro, Matsushima Masaaki, Ogata Katsuhisa, Ishikawa Kinya, Nishida Yoichiro, Ishiguro Taro, Ozaki Kokoro, Nagata Tetsuya, Tsuji Shoji. The Japan MSA registry: A multicenter cohort study of multiple system atrophy(タイトル和訳中) Neurology and Clinical Neuroscience. 2024.09; 12 (5): 271-277. ( ichushi )

  3. Honda T, Matsumura K, Hashimoto Y, Yokota T, Mizusawa H, Nagao S, Ishikawa K. Temporal Relationship between Impairment of Cerebellar Motor Learning and Deterioration of Ataxia in Patients with Cerebellar Degeneration. Cerebellum (London, England). 2024.08; 23 (4): 1280-1292. ( PubMed, DOI )

  4. Wang D, Honda S, Shin MK, Watase K, Mizusawa H, Ishikawa K, Shimizu S. Subcellular localization and ER-mediated cytotoxic function of α1A and α1ACT in spinocerebellar ataxia type 6. Biochemical and biophysical research communications. 2024.02; 695 149481. ( PubMed, DOI )

  5. Rayle Mamuti, Sato Nozomu, Ozaki Kokoro, Higashi Miwa, Okita Michi, Yajima Reiko, Amano Akiko, Mizusawa Hidehiro, Yokota Takanori, Ishikawa Kinya. Degenerative ataxiaの日本人患者167名のコホートを対象とした、多型性を示すSCA37遺伝子座の解析(Analysis of the polymorphic SCA37 locus in a cohort of 167 Japanese patients with degenerative ataxia) Journal of Medical and Dental Sciences. 2024; 71 11-17. ( ichushi )

  6. Ishikawa K. How Certain Are You When Making the Diagnosis of Multiple System Atrophy? Neurology. 2023.12; 101 (24): 1081-1082. ( PubMed, DOI )

  7. Chang S, Torii S, Inamo J, Ishikawa K, Kochi Y, Shimizu S. Uncovering the Localization and Function of a Novel Read-Through Transcript 'TOMM40-APOE'. Cells. 2023.12; 13 (1): ( PubMed, DOI )

  8. Inoue K, Asaka M, Lee S, Ishikawa K, Yanagihara D. Gait disorders induced by photothrombotic cerebellar stroke in mice. Scientific reports. 2023.09; 13 (1): 15805. ( PubMed, DOI )

  9. Shiwaku, H; Katayama, S; Gao, MX; Kondo, K; Nakano, Y; Motokawa, Y; Toyoda, S; Yoshida, F; Hori, H; Kubota, T; Ishikawa, K; Kunugi, H; Ikegaya, Y; Okazawa, H; Takahashi, H. Analyzing schizophrenia-related phenotypes in mice caused by autoantibodies against NRXN1? in schizophrenia BRAIN BEHAVIOR AND IMMUNITY. 2023.07; 111 32-45. ( PubMed, DOI )

  10. Fujino Y, Ueyama M, Ishiguro T, Ozawa D, Ito H, Sugiki T, Murata A, Ishiguro A, Gendron T, Mori K, Tokuda E, Taminato T, Konno T, Koyama A, Kawabe Y, Takeuchi T, Furukawa Y, Fujiwara T, Ikeda M, Mizuno T, Mochizuki H, Mizusawa H, Wada K, Ishikawa K, Onodera O, Nakatani K, Petrucelli L, Taguchi H, Nagai Y. FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD. eLife. 2023.07; 12 ( PubMed, DOI )

  11. Mitsui, J; Matsukawa, T; Uemura, Y; Kawahara, T; Chikada, A; Porto, KJL; Naruse, H; Tanaka, M; Ishiura, H; Toda, T; Kuzuyama, H; Hirano, M; Wada, I; Ga, T; Moritoyo, T; Takahashi, Y; Mizusawa, H; Ishikawa, K; Yokota, T; Kuwabara, S; Sawamoto, N; Takahashi, R; Abe, K; Ishihara, T; Onodera, O; Matsuse, D; Yamasaki, R; Kira, JI; Katsuno, M; Hanajima, R; Ogata, K; Takashima, H; Matsushima, M; Yabe, I; Sasaki, H; Tsuji, S. High-dose ubiquinol supplementation in multiple-system atrophy: a multicentre, randomised, double-blinded, placebo controlled phase 2 trial ECLINICALMEDICINE. 2023.05; 59 101920. ( PubMed, DOI )

  12. Hamanaka K, Yamauchi D, Koshimizu E, Watase K, Mogushi K, Ishikawa K, Mizusawa H, Tsuchida N, Uchiyama Y, Fujita A, Misawa K, Mizuguchi T, Miyatake S, Matsumoto N. Genome-wide identification of tandem repeats associated with splicing variation across 49 tissues in humans. Genome research. 2023.03; 33 (3): 435-447. ( PubMed, DOI )

  13. Ishikawa Kinya. 【神経・精神疾患の遺伝学】脊髄小脳失調症31型(SCA31)(【Genetics of neurological and psychiatric disorders】Spinocerebellar ataxia type 31(SCA31)) Journal of Human Genetics. 2023.03; 68 (3): 153-156. ( ichushi )

  14. Ishikawa, K. Spinocerebellar ataxia type 31 (SCA31) JOURNAL OF HUMAN GENETICS. 2023.03; 68 (3): 153-156. ( PubMed, DOI )

  15. Aoki H, Higashi M, Okita M, Ando N, Murayama S, Ishikawa K, Yokota T. Thymidine Kinase 2 and Mitochondrial Protein COX I in the Cerebellum of Patients with Spinocerebellar Ataxia Type 31 Caused by Penta-nucleotide Repeats (TTCCA)(n). Cerebellum (London, England). 2023.02; 22 (1): 70-84. ( PubMed, DOI )

  16. Saucier J, Al-Qadi M, Amor MB, Ishikawa K, Chamard-Witkowski L. Spinocerebellar ataxia type 31: A clinical and radiological literature review. Journal of the neurological sciences. 2023.01; 444 120527. ( PubMed, DOI )

  17. Zeniya Satoshi, Sanjo Nobuo, Kuwahara Hiroya, Ishikawa Kinya, Higashi Miwa, Matsunaga Akiko, Yoneda Makoto, Mizusawa Hidehiro, Yokota Takanori. 抗アミノ末端α-エノラーゼ自己抗体による脊髄小脳失調症31型の増悪(Spinocerebellar Ataxia Type 31 Exacerbated by Anti-amino Terminal of Alpha-enolase Autoantibodies) Internal Medicine. 2022.09; 61 (18): 2793-2796. ( ichushi )

  18. Winklehner M, Bauer J, Endmayr V, Schwaiger C, Ricken G, Motomura M, Yoshimura S, Shintaku H, Ishikawa K, Tsuura Y, Iizuka T, Yokota T, Irioka T, Höftberger R. Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies. Neurology(R) neuroimmunology & neuroinflammation. 2022.07; 9 (4): ( PubMed, DOI )

  19. Shiwaku, H; Katayama, S; Kondo, K; Nakano, Y; Tanaka, H; Yoshioka, Y; Fujita, K; Tamaki, H; Takebayashi, H; Terasaki, O; Nagase, Y; Nagase, T; Kubota, T; Ishikawa, K; Okazawa, H; Takahashi, H. Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice CELL REPORTS MEDICINE. 2022.04; 3 (4): 100597. ( PubMed, DOI )

  20. Zeniya S, Sanjo N, Kuwahara H, Ishikawa K, Higashi M, Matsunaga A, Yoneda M, Mizusawa H, Yokota T. Spinocerebellar Ataxia Type 31 Exacerbated by Anti-amino Terminal of Alpha-enolase Autoantibodies. Internal medicine (Tokyo, Japan). 2022; 61 (18): 2793-2796. ( PubMed, DOI )

  21. Kubota Tomoya, Hama Manami, Sugiura Yoshihiro, Takahashi Yuji, Ishikawa Kinya, Mizusawa Hidehiro, Takahashi Masanori P.. 日本における発作性運動失調症の全国調査(A nationwide survey of episodic ataxia in Japan) Neurology and Clinical Neuroscience. 2021.11; 9 (6): 443-451. ( ichushi )

  22. Ozaki K, Irioka T, Uchihara T, Yamada A, Nakamura A, Majima T, Igarashi S, Shintaku H, Yakeishi M, Tsuura Y, Okazaki Y, Ishikawa K, Yokota T. Neuropathology of SCA34 showing widespread oligodendroglial pathology with vacuolar white matter degeneration: a case study. Acta neuropathologica communications. 2021.10; 9 (1): 172. ( PubMed, DOI )

  23. Shibata T, Nagano K, Ueyama M, Ninomiya K, Hirose T, Nagai Y, Ishikawa K, Kawai G, Nakatani K. Small molecule targeting r(UGGAA)(n) disrupts RNA foci and alleviates disease phenotype in Drosophila model. Nature communications. 2021.01; 12 (1): 236. ( PubMed, DOI )

  24. Ishiguro T, Nagai Y, Ishikawa K. Insight Into Spinocerebellar Ataxia Type 31 (SCA31) From Drosophila Model. Frontiers in neuroscience. 2021; 15 648133. ( PubMed, DOI )

  25. Ishikawa, K. Molecular Pathogenesis in Spinocerebellar Ataxia Type 31 (SCA31) CEREBELLUM AS A CNS HUB. 2021; 507-516. ( DOI )

  26. Toru S, Ishida S, Uchihara T, Hirokawa K, Kitagawa M, Ishikawa K. Comorbid argyrophilic grain disease in an 87-year-old male with spinocerebellar ataxia type 31 with dementia: a case report. BMC neurology. 2020.04; 20 (1): 136. ( PubMed, DOI )

  27. Ishikawa K, Nagai Y. Molecular Mechanisms and Future Therapeutics for Spinocerebellar Ataxia Type 31 (SCA31). Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2019.11; 16 (4): 1106-1114. ( PubMed, DOI )

  28. Hashiguchi Shunta, Doi Hiroshi, Kunii Misako, Nakamura Yukihiro, Shimuta Misa, Suzuki Etsuko, Koyano Shigeru, Okubo Masaki, Kishida Hitaru, Shiina Masaaki, Ogata Kazuhiro, Hirashima Fumiko, Inoue Yukichi, Kubota Shun, Hayashi Noriko, Nakamura Haruko, Takahashi Keita, Katsumoto Atsuko, Tada Mikiko, Tanaka Kenichi, Sasaoka Toshikuni, Miyatake Satoko, Miyake Noriko, Saitsu Hirotomo, Sato Nozomu, Ozaki Kokoro, Ohta Kiyobumi, Yokota Takanori, Mizusawa Hidehiro, Mitsui Jun, Ishiura Hiroyuki, Yoshimura Jun, Morishita Shinichi, Tsuji Shoji, Takeuchi Hideyuki, Ishikawa Kinya, Matsumoto Naomichi, Ishikawa Taro, Tanaka Fumiaki. Ataxic phenotype with altered Ca(v)3.1 channel property in a mouse model for spinocerebellar ataxia 42 NEUROBIOLOGY OF DISEASE. 2019.10; 130 104516. ( PubMed, DOI )

  29. Ozaki Kokoro, Ansai Ayaka, Nobuhara Kouji, Araki Toshihiko, Kubodera Takayuki, Ishii Takashi, Higashi Miwa, Sato Nozomu, Soga Kazumasa, Mizusawa Hidehiro, Ishikawa Kinya, Yokota Takanori. Prevalence and clinicoradiological features of spinocerebellar ataxia type 34 in a Japanese ataxia cohort PARKINSONISM & RELATED DISORDERS. 2019.08; 65 238-242. ( PubMed, DOI )

  30. Guo Long, Bertola Debora Romeo, Takanohashi Asako, Saito Asuka, Segawa Yuko, Yokota Takanori, Ishibashi Satoru, Nishida Yoichiro, Yamamoto Guilherme Lopes, da Silva Franco Jose Francisco, Honjo Rachel Sayuri, Kim Chong Ae, Musso Camila Manso, Timmons Margaret, Pizzino Amy, Taft Ryan J., Lajoie Bryan, Knight Melanie A., Fischbeck Kenneth H., Singleton Andrew B., Ferreira Carlos R., Wang Zheng, Yan Li, Garbern James Y., Simsek-Kiper Pelin O., Ohashi Hirofumi, Robey Pamela G., Boyde Alan, Matsumoto Naomichi, Miyake Noriko, Spranger Juergen, Schiffmann Raphael, Vanderver Adeline, Nishimura Gen, dos Santos Passos-Bueno Maria Rita, Simons Cas, Ishikawa Kinya, Ikegawa Shiro. Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation AMERICAN JOURNAL OF HUMAN GENETICS. 2019.05; 104 (5): 925-935. ( PubMed, DOI )

  31. Ishikawa Kinya. Calcium channel protein aggregations and role of lysozomes in SCA6 BRAIN PATHOLOGY. 2019.02; 29 8.

  32. Furukawa Fumiko, Ishikawa Kinya, Yokota Takanori, Sanjo Nobuo. Cross-Sectional Area Analysis of the Head of the Caudate Nucleus in Huntington's Disease EUROPEAN NEUROLOGY. 2019; 81 (1-2): 13-18. ( PubMed, DOI )

  33. Bando K, Honda T, Ishikawa K, Takahashi Y, Mizusawa H, Hanakawa T. Impaired Adaptive Motor Learning Is Correlated With Cerebellar Hemispheric Gray Matter Atrophy in Spinocerebellar Ataxia Patients: A Voxel-Based Morphometry Study. Frontiers in neurology. 2019; 10 1183. ( PubMed, DOI )

  34. Ishikawa Kinya, Ishiguro Taro, Nagai Yoshitaka. 神経疾患の克服を目指して　SCA31　分子病態とRNAシャペロンの役割(SCA31: molecular pathogenesis and role of RNA chaperone) 臨床神経学. 2018.12; 58 (Suppl.): S28. ( ichushi )

  35. Honda Takeru, Nagao Soichi, Hashimoto Yuji, Ishikawa Kinya, Yokota Takanori, Mizusawa Hidehiro, Ito Masao. Tandem internal models execute motor learning in the cerebellum PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018.07; 115 (28): 7428-7433. ( PubMed, DOI )

  36. Itaya Sakiko, Kobayashi Zen, Ozaki Kokoro, Sato Nozomu, Numasawa Yoshiyuki, Ishikawa Kinya, Yokota Takanori, Matsuda Hiroshi, Shintani Shuzo. 眼瞼痙攣を伴う脊髄小脳失調症31型(Spinocerebellar Ataxia Type 31 with Blepharospasm) Internal Medicine. 2018.06; 57 (11): 1651-1654. ( ichushi )

  37. Higashi Miwa, Ozaki Kokoro, Hattori Takaaki, Ishii Takashi, Soga Kazumasa, Sato Nozomu, Tomita Makoto, Mizusawa Hidehiro, Ishikawa Kinya, Yokota Takanori. A diagnostic decision tree for adult cerebellar ataxia based on pontine magnetic resonance imaging JOURNAL OF THE NEUROLOGICAL SCIENCES. 2018.04; 387 187-195. ( PubMed, DOI )

  38. Itaya Sakiko, Kobayashi Zen, Ozaki Kokoro, Sato Nozomu, Numasawa Yoshiyuki, Ishikawa Kinya, Yokota Takanori, Matsuda Hiroshi, Shintani Shuzo. Spinocerebellar Ataxia Type 31 with Blepharospasm INTERNAL MEDICINE. 2018; 57 (11): 1651-1654. ( PubMed, DOI )

  39. Hu Yajun, Hashimoto Yuji, Ishii Takashi, Rayle Mamut, Soga Kazumasa, Sato Nozomu, Okita Michi, Higashi Miwa, Ozaki Kokoro, Mizusawa Hidehiro, Ishikawa Kinya, Yokota Takanori. Sequence configuration of spinocerebellar ataxia type 8 repeat expansions in a Japanese cohort of 797 ataxia subjects JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.11; 382 87-90.

  40. Hu Y, Hashimoto Y, Ishii T, Rayle M, Soga K, Sato N, Okita M, Higashi M, Ozaki K, Mizusawa H, Ishikawa K, Yokota T. Sequence configuration of spinocerebellar ataxia type 8 repeat expansions in a Japanese cohort of 797 ataxia subjects. Journal of the neurological sciences. 2017.11; 382 87-90. ( PubMed, DOI )

  41. Ishiguro T., Sato N., Ueyama M., Fujikake N., Sellier C., Tokuda E., Zamiri B., Gall-Duncan T., Mirceta M., Furukawa Y., Yokota T., Wada K., Taylor P., Pearson C. E., Charlet-Berguerand N., Mizusawa H., Nagai Y., Ishikawa K.. Balance between RNA binding proetin TDP-43 and an RNA UGGAA repeat underlies pathogenesis of spinocerebellar ataxia type 31 (SCA31) and motor neuron disease fly models JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 56. ( DOI )

  42. Ueyama M., Ishiguro T., Konno T., Koyama A., Wada K., Ishikawa K., Onodera O., Nagai Y.. Repeat associated non-atg translation and its regulation in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal dementia model fly JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 717. ( DOI )

  43. Sato N., Yokota T., Mizusawa H., Ishikawa K.. Pentanucleotide-repeat-associated unconventional translation is observed in spinocerebellar ataxia type 31 JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 893-894. ( DOI )

  44. Takahashi Y., Ishikawa K., Ugawa Y., Onodera O., Kira J. I., Kuwabara S., Sasaki H., Sobue G., Takashima H., Takiyama Y., Takeda A., Tsuji S., Nakashima K., Miyai I., Yoshida K., Mizusawa H.. Japan Consortium of Ataxias (J-Cat): A Cloud -Based national registry for degenerative ataxias providing framework for genetic diagnosis and Prospective Natural History Researches JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 55. ( DOI )

  45. Ozaki K., Doi H., Mitsui J., Sato N., Yamane K., Majima T., Irioka T., Ishiura H., Doi K., Morishita S., Koyama K., Miura Y., Matsumoto N., Tanaka F., Tsuji S., Mizusawa H., Yokota T., Ishikawa K.. Clinicoradiological characteristics of SCA34 patients with the hot cross bun sign caused by the P.TRP246GLY mutation in ELOVL4 JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 891. ( DOI )

  46. Higashi M., Ozaki K., Hattori T., Ishii T., Soga K., Sato N., Tomita M., Mizusawa H., Ishikawa K., Yokota T.. Cerebellar ataxia subgroups can be differentiated by pontine magnetic resonance imaging JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 305. ( DOI )

  47. Shimmura Mitsunori, Uehara Taira, Yamashita Kenichiro, Shigeto Hiroshi, Yamasaki Ryo, Ishikawa Kinya, Kira Jun-Ichi. Slowed abduction during smooth pursuit eye movement in episodic ataxia type 2 with a novel CACNA1A mutation JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 4-6. ( PubMed, DOI )

  48. Ishiguro Taro, Sato Nozomu, Ueyama Morio, Fujikake Nobuhiro, Sellier Chantal, Kanegami Akemi, Tokuda Eiichi, Zamiri Bita, Gall-Duncan Terence, Mirceta Mila, Furukawa Yoshiaki, Yokota Takanori, Wada Keiji, Taylor J. Paul, Pearson Christopher E., Charlet-Berguerand Nicolas, Mizusawa Hidehiro, Nagai Yoshitaka, Ishikawa Kinya. Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31 NEURON. 2017.04; 94 (1): 108-+. ( PubMed, DOI )

  49. Soga Kazumasa, Ishikawa Kinya, Furuya Tokuro, Iida Tadatsune, Yamada Tetsuo, Ando Noboru, Ota Kiyobumi, Kanno-Okada Hiromi, Tanaka Shinya, Shintaku Masayuki, Eishi Yoshinobu, Mizusawa Hidehiro, Yokota Takanori. Gene dosage effect in spinocerebellar ataxia type 6 homozygotes: A clinical and neuropathological study JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.02; 373 321-328. ( PubMed, DOI )

  50. Chikazawa Sakiko, Hanafusa Takaaki, Ozaki Kokoro, Namiki Takeshi, Amano Maki, Ueno Makiko, Tokoro Shown, Igawa Ken, Sato Takefumi, Ishikawa Kinya, Yokota Takanori, Yokozeki Hiroo. Incomplete Behc, et's disease with calf mus-cle pain and MRI hyperintensity due to possible thrombophlebitis EUROPEAN JOURNAL OF DERMATOLOGY. 2017; 27 (1): 76-77. ( PubMed, DOI )

  51. Kokoro Ozaki, Takashi Irioka, Kinya Ishikawa, Hidehiro Mizusawa. CADASIL with a Novel NOTCH3 Mutation (Cys478Tyr). J Stroke Cerebrovasc Dis. 2015.01; ( PubMed, DOI )

  52. Kokoro Ozaki, Nobuo Sanjo, Kinya Ishikawa, Miwa Higashi, Takaaki Hattori, Naoyuki Tanuma, Rie Miyata, Masaharu Hayashi, Takanori Yokota, Atsushi Okawa, Hidehiro Mizusawa. Elevation of 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of three patients with superficial siderosis Neurology and Clinical Neuroscience. 2015; ( DOI )

  53. Masato Obayashi, Giovanni Stevanin, Matthis Synofzik, Marie-Lorraine Monin, Charles Duyckaerts, Nozomu Sato, Nathalie Streichenberger, Alain Vighetto, Virginie Desestret, Christelle Tesson, H-Erich Wichmann, Thomas Illig, Johanna Huttenlocher, Yasushi Kita, Yuishin Izumi, Hidehiro Mizusawa, Ludger Schöls, Thomas Klopstock, Alexis Brice, Kinya Ishikawa, Alexandra Dürr. Spinocerebellar ataxia type 36 exists in diverse populations and can be caused by a short hexanucleotide GGCCTG repeat expansion. J. Neurol. Neurosurg. Psychiatr.. 2014.12; ( PubMed, DOI )

  54. Chikara Yamashita, Hiroyuki Tomiyama, Manabu Funayama, Saeko Inamizu, Maya Ando, Yuanzhe Li, Hiroyo Yoshino, Takehisa Araki, Tadashi Ichikawa, Yoshiro Ehara, Kinya Ishikawa, Hidehiro Mizusawa, Nobutaka Hattori. Evaluation of polyglutamine repeats in autosomal dominant Parkinson's disease. Neurobiol. Aging. 2014.07; 35 (7): 1779.e17-1779.e21. ( PubMed, DOI )

  55. Kiyobumi Ota, Masato Obayashi, Kokoro Ozaki, Shizuko Ichinose, Akiyoshi Kakita, Mari Tada, Hitoshi Takahashi, Noboru Ando, Yoshinobu Eishi, Hidehiro Mizusawa, Kinya Ishikawa. Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy. Acta Neuropathol Commun. 2014; 2 136. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Higashi Miwa, Okita Michi, Ishii Takashi, Aoki Hanako, Shoji Takao, Onishi Yoshiyuki, Nagata Tetsuya, Koizumi Makoto, Ishikawa Kinya, Yokota Takanori. Antisense oligonucleotide for spinocerebellar ataxia type 31(タイトル和訳中). 臨床神経学 2024.10.01

  2. Ishikawa Kinya. Toward establishing disease-modifying therapy against SCA31(タイトル和訳中). 臨床神経学 2024.10.01

  3. Ishihara Tomohiko, Ikenaka Kensuke, Takahashi Yuji, Yokota Takanori, Ishikawa Kinya, Hirano Makito, Nagai Yoshitaka, Onodera Osamu. Double-blind L-arginine trial against SCA6(タイトル和訳中). 臨床神経学 2024.10.01

  4. Aoki Hanako, Honda Takeru, Amano Akiko, Higashi Miwa, Nagata Tetsuya, Yokota Takanori, Ishikawa Kinya. Clinical biomarker discovery for potential disease-modifying drug of Spinocerebellar ataxia type 31(タイトル和訳中). 臨床神経学 2024.10.01

  5. Ishihara Tomohiko, Ikenaka Kensuke, Takahashi Yuji, Yokota Takanori, Ishikawa Kinya, Hirano Makito, Nagai Yoshitaka, Onodera Osamu. AJA030-002　ポリグルタミン病に対するタンパク質凝集阻害剤の第II相試験(AJA030-002:Phase II Study of a Protein Aggregation Inhibitor for Polyglutamine Disease). 臨床神経学 2023.09.01

  6. Wang Di, Shin Minkyou, Honda Shiya, Mizusaw Hidehiro, Watase Kei, Shimizu Shigeomi, Ishikawa Kinya. SCA6ノックインマウスにおけるSCA6 PolyQ封入体の局在解析(Analysis of localization of SCA6 polyQ inclusions in SCA6 knock-in mouse model). 臨床神経学 2023.09.01

  7. Fujino Yuzo, Ueyama Morio, Ishiguro Taro, Ozawa Daisaku, Ito Hayato, Murata Asako, Tokuda Eiichi, Furukawa Yoshiaki, Mizuno Toshiki, Mochizuki Hideki, Mizusawa Hidehiro, Wada Keiji, Ishikawa Kinya, Onodera Osamu, Nakatani Kazuhiko, Taguchi Hideki, Nagai Yoshitaka. FUSはRNAシャペロンとしてC9orf72関連ALS/FTDのRAN翻訳と神経変性を抑制する(FUS suppresses RAN translation and neurodegeneration as an RNA chaperone in C9orf72-linked ALS/FTD). 臨床神経学 2023.09.01

  8. 常 詩晨, 田中 敏博, 稲澤 譲治, 水澤 英洋, 三條 伸夫, 横田 隆徳, 石川 欽也. 神経疾患の遺伝的リスク評価. 臨床神経学 2023.09.01

  9. Aoki Hanako, Higashi Miwa, Okita Michi, Ishikawa Kinya, Yokota Takanori. Pentanucleotide repeat(TTCCA)nによるSCA31の小脳におけるTK2の発現と機能(Expression and function of TK2 in the cerebellum of SCA31 caused by pentanucleotide repeat (TTCCA)n). 臨床神経学 2022.10.01

  10. Ishihara Tomohiko, Ikenaka Kensuke, Takahashi Yuji, Yokota Takanori, Ishikawa Kinya, Hirano Makito, Nagai Yoshitaka, Onodera Osamu. ポリグルタミン病に対するタンパク質凝集阻害剤の第II相試験(Phase II Study of a Protein Aggregation Inhibitor for Polyglutamine Disease). 臨床神経学 2022.10.01

  11. Higashi Miwa, Okita Michi, Sato Nozomu, Aoki Hanako, Komatsu Takumi, Asaka Meiko, Yanagihara Dai, Yokota Takanori, Ishikawa Kinya. SCA31ペンタヌクレオチド反復配列BACトランスジェニックマウスの運動表現型(Motor phenotype of BAC transgenic mice with SCA31 pentanucleotide repeats). 臨床神経学 2022.10.01

  12. Higashi Miwa, Okita Michi, Aoki Hanako, Ishii Takashi, Nagata Tetsuya, Ishiguro Taro, Yokota Takanori, Ishikawa Kinya. SCA31における双方向性転写産物としてのTGGAAペンタヌクレオチドリピートの役割とは?(What are the roles of TGGAA penta-nucleotide repeats as bidirectional transcripts in SCA31?). 臨床神経学 2021.09.01

  13. Aoki Hanako, Higashi Miwa, Okita Michi, Yokota Takanori, Ishikawa Kinya. ヒトSCA31小脳におけるチミジンキナーゼ2遺伝子の発現状況(Expression of thymidine kinase 2 gene in human SCA31 cerebellum). 臨床神経学 2021.09.01

  14. Higashi Miwa, Okita Michi, Sato Nozomu, Asaka Meiko, Ishii Takashi, Aoki Hanako, Ishiguro Taro, Yanagihara Dai, Yokota Takanori, Ishikawa Kinya. SCA31トランスジェニックマウスはヒトの患者と類似した病理学的特徴を示す(SCA31 transgenic mice show pathologic features similar to human patients). 臨床神経学 2020.11.01

  15. Ishikawa Kinya, Higashi Miwa, Okita Michi, Aoki Hanako, Asaka Meiko, Ishiguro Taro, Sato Nozomu, Nagai Yoshitaka, Yanagihara Dai, Yokota Takanori. 日本から世界へのSCAに関する最初の発見や治療　脊髄小脳失調症31型(SCA31)の病状形成機序(Original discovery and therapy for SCA from Japan to the world　Pathogenesis of spinocerebellar ataxia type 31(SCA31)). 臨床神経学 2020.11.01

  16. Aoki Hanako, Higashi Miwa, Okita Michi, Yokota Takanori, Ishikawa Kinya. 脊髄小脳失調症31型のヒトの脳におけるチミジンキナーゼ2とミトコンドリアタンパク質の発現状況(Expression of thymidine kinase 2 and mitochondrial proteins in SCA31 human brains). 臨床神経学 2020.11.01

  17. Irioka Takashi, Motomura Masakatsu, Uchihara Toshiki, Shintaku Hiroshi, Ishikawa Kinya, Igarashi Susumu, Majima Takamasa, Takahashi Yuko K., Iwase Ryo, Otani Tai, Kitanosono Hiroko, Shiraishi Hirokazu, Tsuura Yukio, Yokota Takanori. カルシウムチャネル抗体関連小脳失調症患者の臨床病理学的研究(Clinicopathological study of a patient with calcium channels antibody-associated cerebellar ataxia). 臨床神経学 2019.11.01

  18. Ishikawa Kinya. リピート病の最前線　SCA31の病因(Frontier of repeat disease　Pathogenesis of SCA31). 臨床神経学 2019.11.01

  19. Ishiguro Taro, Yokota Takanori, Ishikawa Kinya, Nagai Yoshitaka, Petrucelli Leonard. ショウジョウバエのSpt4ノックダウンはSCA31関連の伸長UGGAAリピート誘発毒性を抑制する(Spt4 knockdown suppressed SCA31-linked expanded UGGAA repeat-induced toxicity in Drosophila). 臨床神経学 2019.11.01

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