Personnel Information

写真a

ISHIKAWA Kinya


Job title

Professor

Laboratory Address

Yushima 1-5-45, Bunkyo-ku 113-8519, Tokyo, Japan.

Research Areas, Keywords

Personalized preventive medicine

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Graduating School 【 display / non-display 】

  • University of Tsukuba, School of Medicine, The University of Tsukuba, Medical School, 1989, Graduated

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Graduate School 【 display / non-display 】

  • University of Tsukuba, Graduate School, Division of Medicine, Doctor's Course, 1996, Completed

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Degree 【 display / non-display 】

  • Doctor of Medicine

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Campus Career 【 display / non-display 】

  • 2002.05
    -
    2014.12
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurology， Junior Associate Professor
  • 2015.01
    -
    2016.02
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Professor
  • 1999.04
    -
    2017.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Central Clinical Facilities， Center for Personalized Medicine for Healthy Aging， Professor
  • 2017.04
    -
    2018.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Central Clinical Facilities， Center for Personalized Medicine for Healthy Aging， Professor
  • 2018.04
    -
    2021.09
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Central Clinical Facilities， Center for Personalized Medicine for Healthy Aging， Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Advanced Therapeutic Sciences， Department of Personalized Genomic Medicine for Health， Professor
  • 2021.10
    -
    2023.10
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Integrated Facilities， Center for Personalized Medicine for Healthy Aging， Professor
  • 2023.11
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Advanced Therapeutic Sciences， Department of Personalized Genomic Medicine for Health， Professor

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Academic Society Affiliations 【 display / non-display 】

  • American Academy of Neurology, American Society of Human Genetics

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Research Areas 【 display / non-display 】

  • Personalized genomic medicine

  • Neurology

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Research Theme 【 display / non-display 】

  • Personalized genomic medicine, 2015.01 - Now

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Published Papers & Misc 【 display / non-display 】

  1. Ishikawa K, Nagai Y. Molecular Mechanisms and Future Therapeutics for Spinocerebellar Ataxia Type 31 (SCA31). Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2019.11; ( PubMed, DOI )

  2. Hashiguchi Shunta, Doi Hiroshi, Kunii Misako, Nakamura Yukihiro, Shimuta Misa, Suzuki Etsuko, Koyano Shigeru, Okubo Masaki, Kishida Hitaru, Shiina Masaaki, Ogata Kazuhiro, Hirashima Fumiko, Inoue Yukichi, Kubota Shun, Hayashi Noriko, Nakamura Haruko, Takahashi Keita, Katsumoto Atsuko, Tada Mikiko, Tanaka Kenichi, Sasaoka Toshikuni, Miyatake Satoko, Miyake Noriko, Saitsu Hirotomo, Sato Nozomu, Ozaki Kokoro, Ohta Kiyobumi, Yokota Takanori, Mizusawa Hidehiro, Mitsui Jun, Ishiura Hiroyuki, Yoshimura Jun, Morishita Shinichi, Tsuji Shoji, Takeuchi Hideyuki, Ishikawa Kinya, Matsumoto Naomichi, Ishikawa Taro, Tanaka Fumiaki. Ataxic phenotype with altered Ca(v)3.1 channel property in a mouse model for spinocerebellar ataxia 42 NEUROBIOLOGY OF DISEASE. 2019.10; 130 104516. ( PubMed, DOI )

  3. Ozaki Kokoro, Ansai Ayaka, Nobuhara Kouji, Araki Toshihiko, Kubodera Takayuki, Ishii Takashi, Higashi Miwa, Sato Nozomu, Soga Kazumasa, Mizusawa Hidehiro, Ishikawa Kinya, Yokota Takanori. Prevalence and clinicoradiological features of spinocerebellar ataxia type 34 in a Japanese ataxia cohort PARKINSONISM & RELATED DISORDERS. 2019.08; 65 238-242. ( PubMed, DOI )

  4. Guo Long, Bertola Debora Romeo, Takanohashi Asako, Saito Asuka, Segawa Yuko, Yokota Takanori, Ishibashi Satoru, Nishida Yoichiro, Yamamoto Guilherme Lopes, da Silva Franco Jose Francisco, Honjo Rachel Sayuri, Kim Chong Ae, Musso Camila Manso, Timmons Margaret, Pizzino Amy, Taft Ryan J., Lajoie Bryan, Knight Melanie A., Fischbeck Kenneth H., Singleton Andrew B., Ferreira Carlos R., Wang Zheng, Yan Li, Garbern James Y., Simsek-Kiper Pelin O., Ohashi Hirofumi, Robey Pamela G., Boyde Alan, Matsumoto Naomichi, Miyake Noriko, Spranger Juergen, Schiffmann Raphael, Vanderver Adeline, Nishimura Gen, dos Santos Passos-Bueno Maria Rita, Simons Cas, Ishikawa Kinya, Ikegawa Shiro. Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation AMERICAN JOURNAL OF HUMAN GENETICS. 2019.05; 104 (5): 925-935. ( PubMed, DOI )

  5. Ishikawa Kinya. Calcium channel protein aggregations and role of lysozomes in SCA6 BRAIN PATHOLOGY. 2019.02; 29 8.

  6. Furukawa Fumiko, Ishikawa Kinya, Yokota Takanori, Sanjo Nobuo. Cross-Sectional Area Analysis of the Head of the Caudate Nucleus in Huntington's Disease EUROPEAN NEUROLOGY. 2019; 81 (1-2): 13-18. ( PubMed, DOI )

  7. Ishikawa Kinya, Ishiguro Taro, Nagai Yoshitaka. 神経疾患の克服を目指して　SCA31　分子病態とRNAシャペロンの役割(SCA31: molecular pathogenesis and role of RNA chaperone) 臨床神経学. 2018.12; 58 (Suppl.): S28. ( ichushi )

  8. Honda Takeru, Nagao Soichi, Hashimoto Yuji, Ishikawa Kinya, Yokota Takanori, Mizusawa Hidehiro, Ito Masao. Tandem internal models execute motor learning in the cerebellum PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018.07; 115 (28): 7428-7433. ( PubMed, DOI )

  9. Itaya Sakiko, Kobayashi Zen, Ozaki Kokoro, Sato Nozomu, Numasawa Yoshiyuki, Ishikawa Kinya, Yokota Takanori, Matsuda Hiroshi, Shintani Shuzo. 眼瞼痙攣を伴う脊髄小脳失調症31型(Spinocerebellar Ataxia Type 31 with Blepharospasm) Internal Medicine. 2018.06; 57 (11): 1651-1654. ( ichushi )

  10. Higashi Miwa, Ozaki Kokoro, Hattori Takaaki, Ishii Takashi, Soga Kazumasa, Sato Nozomu, Tomita Makoto, Mizusawa Hidehiro, Ishikawa Kinya, Yokota Takanori. A diagnostic decision tree for adult cerebellar ataxia based on pontine magnetic resonance imaging JOURNAL OF THE NEUROLOGICAL SCIENCES. 2018.04; 387 187-195. ( PubMed, DOI )

  11. Itaya Sakiko, Kobayashi Zen, Ozaki Kokoro, Sato Nozomu, Numasawa Yoshiyuki, Ishikawa Kinya, Yokota Takanori, Matsuda Hiroshi, Shintani Shuzo. Spinocerebellar Ataxia Type 31 with Blepharospasm INTERNAL MEDICINE. 2018; 57 (11): 1651-1654. ( PubMed, DOI )

  12. Hu Yajun, Hashimoto Yuji, Ishii Takashi, Rayle Mamut, Soga Kazumasa, Sato Nozomu, Okita Michi, Higashi Miwa, Ozaki Kokoro, Mizusawa Hidehiro, Ishikawa Kinya, Yokota Takanori. Sequence configuration of spinocerebellar ataxia type 8 repeat expansions in a Japanese cohort of 797 ataxia subjects JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.11; 382 87-90.

  13. Hu Y, Hashimoto Y, Ishii T, Rayle M, Soga K, Sato N, Okita M, Higashi M, Ozaki K, Mizusawa H, Ishikawa K, Yokota T. Sequence configuration of spinocerebellar ataxia type 8 repeat expansions in a Japanese cohort of 797 ataxia subjects. Journal of the neurological sciences. 2017.11; 382 87-90. ( PubMed, DOI )

  14. Ishiguro T., Sato N., Ueyama M., Fujikake N., Sellier C., Tokuda E., Zamiri B., Gall-Duncan T., Mirceta M., Furukawa Y., Yokota T., Wada K., Taylor P., Pearson C. E., Charlet-Berguerand N., Mizusawa H., Nagai Y., Ishikawa K.. Balance between RNA binding proetin TDP-43 and an RNA UGGAA repeat underlies pathogenesis of spinocerebellar ataxia type 31 (SCA31) and motor neuron disease fly models JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 56. ( DOI )

  15. Shimmura Mitsunori, Uehara Taira, Yamashita Kenichiro, Shigeto Hiroshi, Yamasaki Ryo, Ishikawa Kinya, Kira Jun-Ichi. Slowed abduction during smooth pursuit eye movement in episodic ataxia type 2 with a novel CACNA1A mutation JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 4-6. ( PubMed, DOI )

  16. Ueyama M., Ishiguro T., Konno T., Koyama A., Wada K., Ishikawa K., Onodera O., Nagai Y.. Repeat associated non-atg translation and its regulation in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal dementia model fly JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 717. ( DOI )

  17. Sato N., Yokota T., Mizusawa H., Ishikawa K.. Pentanucleotide-repeat-associated unconventional translation is observed in spinocerebellar ataxia type 31 JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 893-894. ( DOI )

  18. Takahashi Y., Ishikawa K., Ugawa Y., Onodera O., Kira J. I., Kuwabara S., Sasaki H., Sobue G., Takashima H., Takiyama Y., Takeda A., Tsuji S., Nakashima K., Miyai I., Yoshida K., Mizusawa H.. Japan Consortium of Ataxias (J-Cat): A Cloud -Based national registry for degenerative ataxias providing framework for genetic diagnosis and Prospective Natural History Researches JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 55. ( DOI )

  19. Ozaki K., Doi H., Mitsui J., Sato N., Yamane K., Majima T., Irioka T., Ishiura H., Doi K., Morishita S., Koyama K., Miura Y., Matsumoto N., Tanaka F., Tsuji S., Mizusawa H., Yokota T., Ishikawa K.. Clinicoradiological characteristics of SCA34 patients with the hot cross bun sign caused by the P.TRP246GLY mutation in ELOVL4 JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 891. ( DOI )

  20. Higashi M., Ozaki K., Hattori T., Ishii T., Soga K., Sato N., Tomita M., Mizusawa H., Ishikawa K., Yokota T.. Cerebellar ataxia subgroups can be differentiated by pontine magnetic resonance imaging JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 305. ( DOI )

  21. Ishiguro Taro, Sato Nozomu, Ueyama Morio, Fujikake Nobuhiro, Sellier Chantal, Kanegami Akemi, Tokuda Eiichi, Zamiri Bita, Gall-Duncan Terence, Mirceta Mila, Furukawa Yoshiaki, Yokota Takanori, Wada Keiji, Taylor J. Paul, Pearson Christopher E., Charlet-Berguerand Nicolas, Mizusawa Hidehiro, Nagai Yoshitaka, Ishikawa Kinya. Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31 NEURON. 2017.04; 94 (1): 108-+. ( PubMed, DOI )

  22. Soga Kazumasa, Ishikawa Kinya, Furuya Tokuro, Iida Tadatsune, Yamada Tetsuo, Ando Noboru, Ota Kiyobumi, Kanno-Okada Hiromi, Tanaka Shinya, Shintaku Masayuki, Eishi Yoshinobu, Mizusawa Hidehiro, Yokota Takanori. Gene dosage effect in spinocerebellar ataxia type 6 homozygotes: A clinical and neuropathological study JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.02; 373 321-328. ( PubMed, DOI )

  23. Chikazawa Sakiko, Hanafusa Takaaki, Ozaki Kokoro, Namiki Takeshi, Amano Maki, Ueno Makiko, Tokoro Shown, Igawa Ken, Sato Takefumi, Ishikawa Kinya, Yokota Takanori, Yokozeki Hiroo. Incomplete Behc, et's disease with calf mus-cle pain and MRI hyperintensity due to possible thrombophlebitis EUROPEAN JOURNAL OF DERMATOLOGY. 2017; 27 (1): 76-77. ( PubMed, DOI )

  24. Kokoro Ozaki, Takashi Irioka, Kinya Ishikawa, Hidehiro Mizusawa. CADASIL with a Novel NOTCH3 Mutation (Cys478Tyr). J Stroke Cerebrovasc Dis. 2015.01; ( PubMed, DOI )

  25. Kokoro Ozaki, Nobuo Sanjo, Kinya Ishikawa, Miwa Higashi, Takaaki Hattori, Naoyuki Tanuma, Rie Miyata, Masaharu Hayashi, Takanori Yokota, Atsushi Okawa, Hidehiro Mizusawa. Elevation of 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of three patients with superficial siderosis Neurology and Clinical Neuroscience. 2015; ( DOI )

  26. Masato Obayashi, Giovanni Stevanin, Matthis Synofzik, Marie-Lorraine Monin, Charles Duyckaerts, Nozomu Sato, Nathalie Streichenberger, Alain Vighetto, Virginie Desestret, Christelle Tesson, H-Erich Wichmann, Thomas Illig, Johanna Huttenlocher, Yasushi Kita, Yuishin Izumi, Hidehiro Mizusawa, Ludger Schöls, Thomas Klopstock, Alexis Brice, Kinya Ishikawa, Alexandra Dürr. Spinocerebellar ataxia type 36 exists in diverse populations and can be caused by a short hexanucleotide GGCCTG repeat expansion. J. Neurol. Neurosurg. Psychiatr.. 2014.12; ( PubMed, DOI )

  27. Chikara Yamashita, Hiroyuki Tomiyama, Manabu Funayama, Saeko Inamizu, Maya Ando, Yuanzhe Li, Hiroyo Yoshino, Takehisa Araki, Tadashi Ichikawa, Yoshiro Ehara, Kinya Ishikawa, Hidehiro Mizusawa, Nobutaka Hattori. Evaluation of polyglutamine repeats in autosomal dominant Parkinson's disease. Neurobiol. Aging. 2014.07; 35 (7): 1779.e17-1779.e21. ( PubMed, DOI )

  28. Kiyobumi Ota, Masato Obayashi, Kokoro Ozaki, Shizuko Ichinose, Akiyoshi Kakita, Mari Tada, Hitoshi Takahashi, Noboru Ando, Yoshinobu Eishi, Hidehiro Mizusawa, Kinya Ishikawa. Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy. Acta Neuropathol Commun. 2014; 2 136. ( PubMed, DOI )

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