Published Papers & Misc - Yokota Takanori

Division display >> ／  All the affair displays  1 - 215 of about 215

  1. Matsubayashi T, Yokoyama K, Tateishi U, Yokota T, Sanjo N. Specifically Decreased Thalamic Blood Flow Following COVID-19 Infection. Clinical nuclear medicine. 2024.11; 49 (11): 1041-1043. ( PubMed, DOI )

  2. Yokote H, Miyazaki Y, Fujimori J, Nishida Y, Toru S, Niino M, Nakashima I, Miura Y, Yokota T. Slowly expanding lesions are associated with disease activity and gray matter loss in relapse-onset multiple sclerosis. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2024.10; ( PubMed, DOI )

  3. Hasegawa J, Nagata T, Ihara K, Tanihata J, Ebihara S, Yoshida-Tanaka K, Yanagidaira M, Ohara M, Sasaki A, Nakayama M, Yamamoto S, Ishii T, Iwata-Hara R, Naito M, Miyata K, Sakaue F, Yokota T. Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model. Nature communications. 2024.09; 15 (1): 7530. ( PubMed, DOI )

  4. Ohara M, Nagata T, Hara RI, Yoshida-Tanaka K, Toide N, Takagi K, Sato K, Takenaka T, Nakakariya M, Miyata K, Maeda Y, Toh K, Wada T, Yokota T. DNA/RNA heteroduplex technology with cationic oligopeptide reduces class-related adverse effects of nucleic acid drugs. Molecular therapy. Nucleic acids. 2024.09; 35 (3): 102289. ( PubMed, DOI )

  5. Takahashi S, Ono D, Shintaku H, Oyama J, Nishida Y, Ishikawa K, Yokota T. Cryptogenic New-onset Refractory Status Epilepticus with Hyperintensity of T1-weighted Magnetic Resonance Imaging in the Bilateral Basal Ganglia: An Autopsy Report. Internal medicine (Tokyo, Japan). 2024.09; ( PubMed, DOI )

  6. Hirata K, Matsuoka K, Tagai K, Endo H, Tatebe H, Ono M, Kokubo N, Kataoka Y, Oyama A, Shinotoh H, Takahata K, Obata T, Dehghani M, Near J, Kawamura K, Zhang MR, Shimada H, Shimizu H, Kakita A, Yokota T, Tokuda T, Higuchi M, Takado Y. In Vivo Assessment of Astrocyte Reactivity in Patients with Progressive Supranuclear Palsy. Annals of neurology. 2024.08; 96 (2): 247-261. ( PubMed, DOI )

  7. Takahashi Sunao, Sanjo Nobuo, Koike Ryuji, Yokota Takanori. Eculizumab administration for myasthenia gravis also stabilizes thrombogenicity of catastrophic antiphospholipid syndrome Clinical and Experimental Neuroimmunology. 2024.08; 15 (3): 143-145. ( ichushi )

  8. Ohara M, Hattori T, Chen Q, Shimano K, Hirata K, Matsui M, Yokota T. Is there a spinal tap responder in progressive supranuclear palsy? The first prospective study. Journal of neurology. 2024.07; 271 (7): 4473-4484. ( PubMed, DOI )

  9. Ohara M, Hirata K, Matsubayashi T, Chen Q, Shimano K, Hanazawa R, Hirakawa A, Yokota T, Hattori T. Circular walking is useful for assessing the risk of falls in early progressive supranuclear palsy. Journal of neurology. 2024.07; ( PubMed, DOI )

  10. Yokote H, Miyazaki Y, Fujimori J, Nishida Y, Toru S, Niino M, Nakashima I, Miura Y, Yokota T. Characterization of Japanese multiple sclerosis patients with progression independent of relapse activity: A 2-year multicenter cohort study. Journal of neuroimmunology. 2024.07; 394 578407. ( PubMed, DOI )

  11. Sakurai K, Tokumaru AM, Yoshida M, Saito Y, Wakabayashi K, Komori T, Hasegawa M, Ikeuchi T, Hayashi Y, Shimohata T, Murayama S, Iwasaki Y, Uchihara T, Sakai M, Yabe I, Tanikawa S, Takigawa H, Adachi T, Hanajima R, Fujimura H, Hayashi K, Sugaya K, Hasegawa K, Sano T, Takao M, Yokota O, Miki T, Kobayashi M, Arai N, Ohkubo T, Yokota T, Mori K, Ito M, Ishida C, Idezuka J, Toyoshima Y, Kanazawa M, Aoki M, Hasegawa T, Watanabe H, Hashizume A, Niwa H, Yasui K, Ito K, Washimi Y, Kubota A, Toda T, Nakashima K, Aiba I, J-VAC study group. Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study. Neuroradiology. 2024.07; ( PubMed, DOI )

  12. Matsubayashi T, Yoshioka K, Lei Mon SS, Katsuyama M, Jia C, Yamaguchi T, Hara RI, Nagata T, Nakagawa O, Obika S, Yokota T. Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine. Molecular therapy. Nucleic acids. 2024.06; 35 (2): 102161. ( PubMed, DOI )

  13. Sano T, Nagata T, Ebihara S, Yoshida-Tanaka K, Nakamura A, Sasaki A, Shimozawa A, Mochizuki H, Uchihara T, Hasegawa M, Yokota T. Effects of local reduction of endogenous α-synuclein using antisense oligonucleotides on the fibril-induced propagation of pathology through the neural network in wild-type mice. Acta neuropathologica communications. 2024.05; 12 (1): 75. ( PubMed, DOI )

  14. Ono D, Kawai H, Kuwahara H, Yokota T. Automated whole slide morphometry of sural nerve biopsy using machine learning. Neuropathology and applied neurobiology. 2024.04; 50 (2): e12967. ( PubMed, DOI )

  15. Amano E, Sato W, Kimura Y, Kimura A, Lin Y, Okamoto T, Sato N, Yokota T, Yamamura T. CD11c(high) B Cell Expansion Is Associated With Severity and Brain Atrophy in Neuromyelitis Optica. Neurology(R) neuroimmunology & neuroinflammation. 2024.03; 11 (2): e200206. ( PubMed, DOI )

  16. Sanjo N, Suzuki M, Yoshihama R, Toyoshima Y, Mizuta I, Fujita N, Usuda H, Uchiyama Y, Yasuda R, Yoshida T, Yamada M, Yokota T. Substitution of Glu to Lys at Codon 332 on the GFAP Gene Alone Is Causative for Adult-onset Alexander Disease. Internal medicine (Tokyo, Japan). 2024.01; 63 (2): 309-313. ( PubMed, DOI )

  17. Okamoto T, Ishizuka T, Shimizu R, Asahina Y, Nakamura H, Shimizu Y, Nishida Y, Yokota T, Lin Y, Sato W, Yamamura T. Efficacy and Safety of the Natural Killer T Cell-Stimulatory Glycolipid OCH-NCNP1 for Patients With Relapsing Multiple Sclerosis: Protocol for a Randomized Placebo-Controlled Clinical Trial. JMIR research protocols. 2024.01; 13 e46709. ( PubMed, DOI )

  18. Nishina K, Yoshioka K, Yokota T, Hara RI. Comparison of interaction between antimiR and microRNA versus HDO-antimiR and microRNA by molecular dynamics simulation. Nucleosides, nucleotides & nucleic acids. 2024.01; 1-16. ( PubMed, DOI )

  19. Yum J, Aulia F, Kamiya K, Hori M, Qiao N, Kim BS, Naito M, Ogura S, Nagata T, Yokota T, Uchida S, Obika S, Kim HJ, Miyata K. Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery. Bioconjugate chemistry. 2024.01; 35 (2): 125-131. ( PubMed, DOI )

  20. Sanjo Nobuo, Suzuki Motohiro, Yoshihama Rei, Toyoshima Yasuko, Mizuta Ikuko, Fujita Nobuya, Usuda Hiroyuki, Uchiyama Yumiko, Yasuda Rei, Yoshida Tomokatsu, Yamada Masahito, Yokota Takanori. GFAP遺伝子コドン332におけるGluのLysへの置換は単独で成人発症アレキサンダー病の原因となる(Substitution of Glu to Lys at Codon 332 on the GFAP Gene Alone Is Causative for Adult-onset Alexander Disease) Internal Medicine. 2024.01; 63 (2): 309-313. ( ichushi )

  21. Rayle Mamuti, Sato Nozomu, Ozaki Kokoro, Higashi Miwa, Okita Michi, Yajima Reiko, Amano Akiko, Mizusawa Hidehiro, Yokota Takanori, Ishikawa Kinya. Analysis of the polymorphic SCA37 locus in a cohort of 167 Japanese patients with degenerative ataxia Journal of Medical and Dental Sciences. 2024; 71 11-17. ( ichushi )

  22. Maruoka H, Hattori T, Hase T, Takahashi K, Ohara M, Orimo S, Yokota T. Aberrant morphometric networks in Alzheimer's disease have hemispheric asymmetry and age dependence. The European journal of neuroscience. 2023.12; ( PubMed, DOI )

  23. Kawai H, Matsubayashi T, Yokota T, Sanjo N. Serial changes in regional cerebral blood flow in Gerstmann-Sträussler-Scheinker disease caused by a Pro-to-Leu mutation at codon 105 in the prion protein gene. Prion. 2023.12; 17 (1): 138-140. ( PubMed, DOI )

  24. Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G, Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group. Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients. Journal of neurology, neurosurgery, and psychiatry. 2023.10; 94 (10): 816-824. ( PubMed, DOI )

  25. Hirata K, Matsuoka K, Tagai K, Endo H, Tatebe H, Ono M, Kokubo N, Oyama A, Shinotoh H, Takahata K, Obata T, Dehghani M, Near J, Kawamura K, Zhang MR, Shimada H, Yokota T, Tokuda T, Higuchi M, Takado Y. Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease. Annals of neurology. 2023.09; ( PubMed, DOI )

  26. Hattori T, Ohara M, Yuasa T, Azuma R, Chen Q, Hanazawa R, Hirakawa A, Orimo S, Yokota T. Correlation of callosal angle at the splenium with gait and cognition in normal pressure hydrocephalus. Journal of neurosurgery. 2023.08; 139 (2): 481-491. ( PubMed, DOI )

  27. Iida S, Kanouchi T, Hattori T, Kanai K, Nakazato T, Hattori N, Yokota T. Verification of propagation hypothesis in patients with sporadic hand onset amyotrophic lateral sclerosis. Acta neurologica Belgica. 2023.08; 123 (4): 1511-1517. ( PubMed, DOI )

  28. Noda K, Hattori Y, Hori M, Nakaoku Y, Tanaka A, Yoshimoto T, Nishimura K, Yokota T, Harada-Shiba M, Ihara M. Amplified Risk of Intracranial Artery Stenosis/Occlusion Associated With RNF213 p.R4810K in Familial Hypercholesterolemia. JACC. Asia. 2023.08; 3 (4): 625-633. ( PubMed, DOI )

  29. Miura M, Sakaue F, Matsuno H, Morita K, Yoshida A, Hara RI, Nishimura R, Nishida Y, Yokogawa M, Osawa M, Yokota T. TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate. FEBS letters. 2023.06; 597 (12): 1667-1676. ( PubMed, DOI )

  30. Mitsui J, Matsukawa T, Uemura Y, Kawahara T, Chikada A, Porto KJL, Naruse H, Tanaka M, Ishiura H, Toda T, Kuzuyama H, Hirano M, Wada I, Ga T, Moritoyo T, Takahashi Y, Mizusawa H, Ishikawa K, Yokota T, Kuwabara S, Sawamoto N, Takahashi R, Abe K, Ishihara T, Onodera O, Matsuse D, Yamasaki R, Kira JI, Katsuno M, Hanajima R, Ogata K, Takashima H, Matsushima M, Yabe I, Sasaki H, Tsuji S. High-dose ubiquinol supplementation in multiple-system atrophy: a multicentre, randomised, double-blinded, placebo-controlled phase 2 trial. EClinicalMedicine. 2023.05; 59 101920. ( PubMed, DOI )

  31. Honda T, Matsumura K, Hashimoto Y, Yokota T, Mizusawa H, Nagao S, Ishikawa K. Temporal Relationship between Impairment of Cerebellar Motor Learning and Deterioration of Ataxia in Patients with Cerebellar Degeneration. Cerebellum (London, England). 2023.04; 23 (4): 1280-1292. ( PubMed, DOI )

  32. Li F, Ichinose K, Ishibashi S, Yamamoto S, Iwasawa E, Suzuki M, Yoshida-Tanaka K, Yoshioka K, Nagata T, Hirabayashi H, Mogushi K, Yokota T. Preferential delivery of lipid-ligand conjugated DNA/RNA heteroduplex oligonucleotide to ischemic brain in hyperacute stage. Molecular therapy : the journal of the American Society of Gene Therapy. 2023.04; 31 (4): 1106-1122. ( PubMed, DOI )

  33. Yanagidaira M, Yoshioka K, Nagata T, Nakao S, Miyata K, Yokota T. Effects of combinations of gapmer antisense oligonucleotides on the target reduction. Molecular biology reports. 2023.04; 50 (4): 3539-3546. ( PubMed, DOI )

  34. Miyashita A, Kobayashi M, Yokota T, Zochodne DW. Diabetic Polyneuropathy: New Strategies to Target Sensory Neurons in Dorsal Root Ganglia. International journal of molecular sciences. 2023.03; 24 (6): ( PubMed, DOI )

  35. Jia C, Lei Mon SS, Yang Y, Katsuyama M, Yoshida-Tanaka K, Nagata T, Yoshioka K, Yokota T. Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route. Molecular therapy. Nucleic acids. 2023.03; 31 182-196. ( PubMed, DOI )

  36. Ohara M, Hirata K, Hallett M, Matsubayashi T, Chen Q, Kina S, Shimano K, Hirakawa A, Yokota T, Hattori T. Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients. Parkinsonism & related disorders. 2023.03; 108 105322. ( PubMed, DOI )

  37. Koide T, Mandai S, Kitaoka R, Matsuki H, Chiga M, Yamamoto K, Yoshioka K, Yagi Y, Suzuki S, Fujiki T, Ando F, Mori T, Susa K, Iimori S, Naito S, Sohara E, Rai T, Yokota T, Uchida S. Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease. Circulation research. 2023.02; 132 (4): 415-431. ( PubMed, DOI )

  38. Amano A, Sanjo N, Araki W, Anraku Y, Nakakido M, Matsubara E, Tomiyama T, Nagata T, Tsumoto K, Kataoka K, Yokota T. Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain. Journal of nanobiotechnology. 2023.01; 21 (1): 36. ( PubMed, DOI )

  39. Aiba I, Hayashi Y, Shimohata T, Yoshida M, Saito Y, Wakabayashi K, Komori T, Hasegawa M, Ikeuchi T, Tokumaru AM, Sakurai K, Murayama S, Hasegawa K, Uchihara T, Toyoshima Y, Saito Y, Yabe I, Tanikawa S, Sugaya K, Hayashi K, Sano T, Takao M, Sakai M, Fujimura H, Takigawa H, Adachi T, Hanajima R, Yokota O, Miki T, Iwasaki Y, Kobayashi M, Arai N, Ohkubo T, Yokota T, Mori K, Ito M, Ishida C, Tanaka M, Idezuka J, Kanazawa M, Aoki K, Aoki M, Hasegawa T, Watanabe H, Hashizume A, Niwa H, Yasui K, Ito K, Washimi Y, Mukai E, Kubota A, Toda T, Nakashima K, J-VAC study group. Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome. Brain communications. 2023; 5 (6): fcad296. ( PubMed, DOI )

  40. Matsuda H, Okita K, Motoi Y, Mizuno T, Ikeda M, Sanjo N, Murakami K, Kambe T, Takayama T, Yamada K, Suehiro T, Matsunaga K, Yokota T, Tateishi U, Shigemoto Y, Kimura Y, Chiba E, Kawashima T, Tomo Y, Tachimori H, Kimura Y, Sato N. Clinical impact of amyloid PET using (18)F-florbetapir in patients with cognitive impairment and suspected Alzheimer's disease: a multicenter study. Annals of nuclear medicine. 2022.12; 36 (12): 1039-1049. ( PubMed, DOI )

  41. Matsuda Hiroshi, Okita Kyoji, Motoi Yumiko, Mizuno Toshiki, Ikeda Manabu, Sanjo Nobuo, Murakami Koji, Kambe Taiki, Takayama Toshiki, Yamada Kei, Suehiro Takashi, Matsunaga Keiko, Yokota Takanori, Tateishi Ukihide, Shigemoto Yoko, Kimura Yukio, Chiba Emiko, Kawashima Takahiro, Tomo Yui, Tachimori Hisateru, Kimura Yuichi, Sato Noriko. 認知障害およびAlzheimer病疑い患者への18F-florbetapirによるアミロイドPET検査が臨床に及ぼす影響　多施設共同研究(Clinical impact of amyloid PET using 18F-florbetapir in patients with cognitive impairment and suspected Alzheimer's disease: a multicenter study) Annals of Nuclear Medicine. 2022.12; 36 (12): 1039-1049. ( ichushi )

  42. Ohara M, Sanjo N, Kanouchi T, Yokota T. Entrapment partly participates in the longitudinal progression of neuropathy with anti-MAG antibodies. Revue neurologique. 2022.11; 179 (1-2): 118-122. ( PubMed, DOI )

  43. Chen Q, Hattori T, Tomisato H, Ohara M, Hirata K, Yokota T, Alzheimer's Disease Neuroimaging Initiative. Turning and multitask gait unmask gait disturbance in mild-to-moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage. Human brain mapping. 2022.11; 44 (3): 1193-1208. ( PubMed, DOI )

  44. Goto A, Yamamoto S, Igari T, Matsumoto SI, Chisaki I, Iida K, Nakayama M, Oda A, Kakoi Y, Uchida A, Miyata K, Nishikawa M, Nagata T, Kusuhara H, Yokota T, Hirabayashi H. Quantitative Model Analysis and Simulation of Pharmacokinetics and Malat1 RNA Knockdown Effect After Systemic Administration of Cholesterol-conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood-Brain Barrier of Mice. The Journal of pharmacology and experimental therapeutics. 2022.10; 384 (1): 197-204. ( PubMed, DOI )

  45. Zeniya S, Sanjo N, Kuwahara H, Ishikawa K, Higashi M, Matsunaga A, Yoneda M, Mizusawa Ho, Yokota T. Spinocerebellar Ataxia Type 31 Exacerbated by Anti-amino Terminal of Alpha-enolase Autoantibodies Internal Medicine. 2022.09; 61 (18): 2793-2796. ( ichushi )

  46. Winklehner M, Bauer J, Endmayr V, Schwaiger C, Ricken G, Motomura M, Yoshimura S, Shintaku H, Ishikawa K, Tsuura Y, Iizuka T, Yokota T, Irioka T, Höftberger R. Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies. Neurology(R) neuroimmunology & neuroinflammation. 2022.07; 9 (4): e200006. ( PubMed, DOI )

  47. Yokote H, Miyazaki Y, Toru S, Nishida Y, Hattori T, Niino M, Sanjo N, Yokota T. High-efficacy therapy reduces subcortical grey matter volume loss in Japanese patients with relapse-onset multiple sclerosis: A 2-year cohort study. Mult Scler Relat Disord. 2022.07; 67 104077. ( PubMed, DOI )

  48. Kaburagi H, Nagata T, Enomoto M, Hirai T, Ohyagi M, Ihara K, Yoshida-Tanaka K, Ebihara S, Asada K, Yokoyama H, Okawa A, Yokota T. Systemic DNA/RNA heteroduplex oligonucleotide administration for regulating the gene expression of dorsal root ganglion and sciatic nerve. Molecular therapy. Nucleic acids. 2022.06; 28 910-919. ( PubMed, DOI )

  49. Tamaki Kana, Nishida Yoichiro, Sanjo Nobuo, Yokota Takanori. A patient with generalized myasthenia gravis facing an impending crisis triggered by early fast-acting treatment Clinical and Experimental Neuroimmunology. 2022.05; 13 (2): 99-101. ( ichushi )

  50. Matsubayashi T, Akaza M, Hayashi Y, Hamaguchi T, Satoh K, Kosami K, Ae R, Kitamoto T, Yamada M, Shimohata T, Yokota T, Sanjo N. Specific electroencephalogram features in the very early phases of sporadic Creutzfeldt-Jakob disease. J Neurol Sci. 2022.04; 437 120265. ( PubMed, DOI )

  51. Uematsu M, Mikami K, Nakamura A, Takahashi R, Yokota T, Hirokawa K, Uchihara T. Parallel gold enhancement of quantum dots 565/655 for double-labelling correlative light and electron microscopy on human autopsied samples. Sci Rep. 2022.04; 12 (1): 6113. ( PubMed, DOI )

  52. Bannawongsil T, Yamada A, Nakamura A, Uchihara T, Yokota T. Neuronal internalization of immunoglobulin G injected into the mouse brain by a novel absorption strategy to avoid unwanted interaction with immune complex using centrifugal filtration. Histochemistry and cell biology. 2022.04; ( PubMed, DOI )

  53. Noda Kotaro, Nosaka Nobuyuki, Hara Nobuhiro, Yokota Takanori, Shigemitsu Hidenobu, Takahashi Hideo. 「関連痛」に注意する必要がある　食道穿孔の診断を隠し遅延させた急性心筋梗塞の1症例(We Should Pay Attention to "Referred Pain": A Case of Acute Myocardial Infarction That Masked and Delayed the Diagnosis of Esophageal Perforation) Internal Medicine. 2022.04; 61 (8): 1295-1298. ( ichushi )

  54. Taniguchi K, Yamamoto F, Amamo A, Tamaoka A, Sanjo N, Yokota T, Kametani F, Araki W. Amyloid-β oligomers interact with NMDA receptors containing GluN2B subunits and metabotropic glutamate receptor 1 in primary cortical neurons: Relevance to the synapse pathology of Alzheimer's disease. Neurosci Res. 2022.03; ( PubMed, DOI )

  55. Iwase R, Kanouchi T, Yoshii T, Ishiguro T, Hirai T, Okawa A, Yokota T, Sanjo N. Diverging pathophysiology in superficial siderosis with proximal upper limb amyotrophy. J Neurol Sci. 2022.03; 436 120248. ( PubMed, DOI )

  56. Miyashita A, Kobayashi M, Ishibashi S, Nagata T, Chandrasekahr A, Zochodne DW, Yokota T. The Role of Long Non-coding RNA MALAT1 in Diabetic Polyneuropathy and the Impact of its Silencing in the Dorsal Root Ganglion by a DNA/RNA Heteroduplex Oligonucleotide. Diabetes. 2022.03; 71 (6): 1299-1312. ( PubMed, DOI )

  57. Yamada A, Nishida Y, Wake K, Nakamura A, Sakamaki Y, Kuwahara H, Uchihara T, Yokota T. Serial ultrathin sections to identify ultrastructural localization of GLUT1 molecules in vesicles in brain endothelial cells-correlative light and electron microscopy in depth. Microscopy (Oxford, England). 2022.02; 71 (2): 124-131. ( PubMed, DOI )

  58. Nishi R, Ohyagi M, Nagata T, Mabuchi Y, Yokota T. Regulation of activated microglia and macrophages by systemically administered DNA/RNA heteroduplex oligonucleotides. Mol Ther. 2022.02; 30 (6): 2210-23. ( PubMed, DOI )

  59. Aoki H, Higashi M, Okita M, Ando N, Murayama S, Ishikawa K, Yokota T. Thymidine Kinase 2 and Mitochondrial Protein COX I in the Cerebellum of Patients with Spinocerebellar Ataxia Type 31 Caused by Penta-nucleotide Repeats (TTCCA)<sub>n</sub>. Cerebellum . 2022.01; 22 (1): 70-84. ( PubMed, DOI )

  60. Yoshii T, Hirai T, Egawa S, Hashimoto M, Matsukura Y, Inose H, Sanjo N, Yokota T, Okawa A. Case Report: Dural Dissection With Ventral Spinal Fluid-Filled Collection in Superficial Siderosis: Insights Into the Pathology From Anterior-Approached Surgical Cases. Front Neurol. 2022; 13 919280. ( PubMed, DOI )

  61. Zeniya S, Sanjo N, Kuwahara H, Ishikawa K, Higashi M, Matsunaga A, Yoneda M, Mizusawa H, Yokota T. Spinocerebellar Ataxia Type 31 Exacerbated by Anti-amino Terminal of Alpha-enolase Autoantibodies. Internal medicine (Tokyo, Japan). 2022; 61 (18): 2793-2796. ( PubMed, DOI )

  62. Eiichiro Amano, Tomokatsu Yoshida, Ikuko Mizuta, Jun Oyama, Shingo Sakashita, Syunsuke Ueyama, Akira Machida, Takanori Yokota. Activation of a Cryptic Splice Site of GFAP in a Patient With Adult-Onset Alexander Disease. Neurol Genet. 2021.12; 7 (6): e626. ( PubMed, DOI )

  63. Masaki Ohyagi, Tetsuya Nagata,Kensuke Ihara, Kie Yoshida-Tanaka, Rieko Nishi, Haruka Miyata, Aya Abe,Yo Mabuchi, Chihiro Akazawa, Takanori Yokota. DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo. Nat Commun. 2021.12; 12 (1): 7344. ( PubMed, DOI )

  64. Tohnai G, Nakamura R, Atsuta N, Nakatochi M, Hayashi N, Ito D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Taniguchi A, Kanai K, Morita M, Kano O, Kuwabara S, Oda M, Abe K, Aoki M, Aiba I, Okamoto K, Mizoguchi K, Ishihara T, Kawata A, Yokota T, Hasegawa K, Nagano I, Yabe I, Tanaka F, Kuru S, Hattori N, Nakashima K, Kaji R, Sobue G, Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS).. Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 2021.12; 113 131-136. ( PubMed, DOI )

  65. Yoichiro Nishida,Taro Ishiguro, Takanori Yokota. Tap-Elicited Clonus of the Biceps and Triceps Brachii. JAMA Neurol. 2021.11; 79 (2): 194. ( PubMed, DOI )

  66. Yagi Yohsuke, Asami Yutaro, Kyoya Mitsuki, Yokota Takanori. Cerebral venous sinus thrombosis after mRNA-based COVID-19 vaccination. Neurol　Sci. 2021.11; ( PubMed, DOI )

  67. Takayuki Kuroda, Miho Akaza, Kazunori Miki, Shoko Fujii, Yousuke Yagi, Tadashi Kanouchi, Nobuo Sanjo, Kazutaka Sumita, Takanori Yokota. Sacral dural arteriovenous fistula mimicking multiple mononeuropathy. Clin Neurol Neurosurg. 2021.10; 210 106993. ( PubMed, DOI )

  68. Yurie Nose, Ikuko Uwano, Ukihide Tateishi, Makoto Sasaki, Takanori Yokota, Nobuo Sanjo. Quantitative clinical and radiological recovery in post-operative patients with superficial siderosis by an iron chelator. J Neurol. 2021.10; 269 (5): 2539-2548. ( PubMed, DOI )

  69. Kokoro Ozaki, Takashi Irioka, Toshiki Uchihara, Akane Yamada, Ayako Nakamura, Takamasa Majima, Susumu Igarashi, Hiroshi Shintaku, Mayumi Yakeishi, Yukio Tsuura, Yasushi Okazaki, Kinya Ishikawa, Takanori Yokota. Neuropathology of SCA34 showing widespread oligodendroglial pathology with vacuolar white matter degeneration: a case study. Acta neuropathol commun. 2021.10; 9 (1): 172. ( PubMed, DOI )

  70. Kotaro Noda, Nobuyuki Nosaka, Nobuhiro Hara, Takanori Yokota, Hidenobu Shigemitsu, Hideo Takahashi. We Should Pay Attention to "Referred Pain" - A Case of Acute Myocardial Infarction that Masked and Delayed the Diagnosis of Esophageal Perforation. Intern Med. 2021.09; 61 (8): 1295-1298. ( PubMed, DOI )

  71. Tetsuya Nagata, Chrissa A. Dwyer, Kie Yoshida-Tanaka, Kensuke Ihara, Masaki Ohyagi, Hidetoshi Kaburagi, Haruka Miyata, Satoe Ebihara, Kotaro Yoshioka, Takashi Ishii, Kanjiro Miyata, Kenichi Miyata, Berit Powers, Tomoko Igari, Syunsuke Yamamoto, Naoto Arimura, Hideki Hirabayashi, Toshiki Uchihara, Rintaro Iwata Hara, Takeshi Wada, C. Frank Bennett, Punit P. Seth, Frank Rigo and Takanori Yokota. Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS. Nat Biotechnol. 2021.08; ( PubMed, DOI )

  72. Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian Jf Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa. DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. Life Sci Alliance. 2021.07; 4 (7): ( PubMed, DOI )

  73. Motohiro Suzuki, Satoru Ishibashi, Eri Iwasawa , Takahiro Oguma, Yasuhiro Saito, Fuying Li, Shinichi Otsu, Keiko Ichinose, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota. Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol-conjugated heteroduplex oligonucleotide in mice. Sci Rep. 2021.07; 11 (1): 14237. ( PubMed, DOI )

  74. Kazumasa Kawata, Hideyuki Koga, Kunikazu Tsuji, Kazumasa Miyatake, Yusuke Nakagawa, Takanori Yokota, Ichiro Sekiya, Hiroki Katagiri . Extracellular vesicles derived from mesenchymal stromal cells mediate endogenous cell growth and migration via the CXCL5 and CXCL6/CXCR2 axes and repair menisci. Stem cell research & therapy. 2021.07; 12 (1): 414. ( PubMed, DOI )

  75. Shinya Akiko, Takahashi Makoto, Sato Nozomu, Nishida Yoichiro, Inaba Akira, Inaji Motoki, Yokota Takanori, Orimo Satoshi. Oculo-dento-digital Dysplasia Presenting as Spastic Paraparesis Which Was Successfully Treated by Intrathecal Baclofen Therapy Internal Medicine. 2021.07; 60 (14): 2301-2305. ( ichushi )

  76. Ken Asada, Fumika Sakaue, Tetsuya Nagata, Ji-Chun Zhang, Kie Yoshida-Tanaka, Aya Abe, Makiko Nawa, Kazutaka Nishina , Takanori Yokota. Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing. Nucleic Acids Res.. 2021.05; 49 (9): 4864-4876. ( PubMed, DOI )

  77. Yoichiro Nishida, Takanori Yokota. Reversible reduction of dopamine transporter uptake in a case of hydrocephalus. Ann Neurol. 2021.05; ( PubMed, DOI )

  78. Kotaro Noda,Yosuke Yagi, Takanori Yokota. Evaluation of the risk factors predicting thrombotic complications associated with intravenous immunoglobulin therapy in neuroimmunological diseases Neurol Sci.. 2021.04; 42 (12): 5321-5326. ( PubMed, DOI )

  79. Nobuo Sanjo, Yurie Nose, Shouhei Miyamoto, Yukiko Shishido-Hara, Tatsuya Saito, Tetsuya Fukuda, Kurara Yamamoto, Daisuke Kobayashi, Takanori Yokota. Early pathological JC virus lesions in a patient without any MRI-based indications Inten Med. 2021.04; 60 (8): 1279-1282. ( ichushi )

  80. Ono D, Asada K, Yui D, Sakaue F, Yoshioka K, Nagata T, Yokota T. Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking. Molecular therapy. Nucleic acids. 2021.03; 23 1360-1370. ( PubMed, DOI )

  81. Hiroaki Yokote, Shuta Toru, Yoichiro Nishida, Takaaki Hattori, Nobuo Sanjo, Takanori Yokota . Serum amyloid A level correlates with T2 lesion volume and cortical volume in patients with multiple sclerosis. J Neuroimmunol. 2021.02; 351 577466. ( PubMed, DOI )

  82. Akiko Shinya, Makoto Takahashi, Nozomu Sato, Yoichiro Nishida, Akira Inaba, Motoki Inaji, Takanori Yokota, Satoshi Orimo. A case of oculo-dento-digital dysplasia presenting as spastic paraparesis which was successfully treated by intrathecal baclofen therapy. Intern Med. 2021.02; 60 (14): 2301-2305. ( PubMed, DOI )

  83. Asami Yutaro, Nagata Tetsuya, Yoshioka Kotaro, Kunieda Taiki, Yoshida-Tanaka Kie, Bennett C. Frank, Seth Punit P., Yokota Takanori. Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo. Mol Ther. 2021.02; 29 (2): 838-847. ( PubMed, DOI )

  84. Mitsuru Watanabe, Yuri Nakamura, Shinya Sato, Masaaki Niino, Hikoaki Fukaura, Masami Tanaka, Hirofumi Ochi, Takashi Kanda, Yukio Takeshita, Takanori Yokota, Yoichiro Nishida, Makoto Matsui, Shigemi Nagayama, Susumu Kusunoki, Katsuichi Miyamoto, Masanori Mizuno, Izumi Kawachi, Etsuji Saji, Takashi Ohashi, Shun Shimohama, Shin Hisahara, Kazutoshi Nishiyama, Takahiro Iizuka, Yuji Nakatsuji, Tatsusada Okuno, Kazuhide Ochi, Akio Suzumura, Ken Yamamoto, Yuji Kawano, Shoji Tsuji, Makoto Hirata, Ryuichi Sakate, Tomonori Kimura, Yuko Shimizu, Akiko Nagaishi, Kazumasa Okada, Fumie Hayashi, Ayako Sakoda, Katsuhisa Masaki, Koji Shinoda, Noriko Isobe, Takuya Matsushita, Jun-Ichi Kira . HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data. Sci rep. 2021.01; 11 (1): 607. ( PubMed, DOI )

  85. Mitsuru Naito, Hiroyuki Chaya, Kazuko Toh, Beob Soo Kim, Kotaro Hayashi, Shigeto Fukushima, Tetsuya Nagata, Takanori Yokota, Kazunori Kataoka, Kanjiro Miyata. Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(l-lysine). J control Release . 2021.01; 330 812-820. ( PubMed, DOI )

  86. Matsubayashi T, Akaza M, Hayashi Y, Hamaguchi T, Yamada M, Shimohata T, Yokota T, Sanjo N. Focal sharp waves are a specific early-stage marker of the MM2-cortical form of sporadic Creutzfeldt-Jakob disease. Prion. 2020.12; 14 (1): 207-213. ( PubMed, DOI )

  87. Takahashi S, Sanjo N, Miyamoto S, Hattori T, Oyama J, Tateishi U, Yokota T. Width of the third ventricle as a highly-sensitive biomarker in chronic progressive neuro-Behçet's disease. J Neurol Sci. 2020.12; 421 117284. ( PubMed, DOI )

  88. Akaza M, Kawabata S, Ozaki I, Miyano Y, Watanabe T, Adachi Y, Sekihara K, Sumi Y, Yokota T. Noninvasive measurement of sensory action currents in the cervical cord by magnetospinography. Clin Neurophysiol. 2020.12; 132 (2): 382-391. ( PubMed, DOI )

  89. Sugita Y, Nishida Y, Ishibashi S, Yokota T. Convexity Subarachnoid Hemorrhage Soon after Starting a Direct Oral Anticoagulant in 2 Patients with Acute Infarction. J Stroke Cerebrovasc Dis .. 2020.11; 29 (11): 105216. ( PubMed, DOI )

  90. Sanjo N, Nose Y, Miyamoto S, Shishido-Hara Y, Saito T, Fukuda T, Yamamoto K, Kobayashi D, Yokota T. Early Pathological JC Virus Lesions in a Patient without any MRI-based Indications. Intern Med. 2020.11; 60 (8): 1279-1282. ( PubMed, DOI )

  91. Hirata K, Yokota T, Miura Y. Teaching-Neuroimages: Parkinsonism secondary to a metastatic lesion involving the substantia nigra. Neurology. 2020.11; 96 (13): e1800-e1801. ( PubMed, DOI )

  92. Yokoyama H, Hirai T, Nagata T, Enomoto M, Kaburagi H, Leiyo L, Motoyoshi T, Yoshii T, Okawa A, Yokota T. DNA Microarray Analysis of Differential Gene Expression in the Dorsal Root Ganglia of Four Different Neuropathic Pain Mouse Models. J Pain Res. 2020.11; 13 3031-3043. ( PubMed, DOI )

  93. Yuko Yamagishi, Motoi Kuwahara, Hidekazu Suzuki, Masahiro Sonoo, Satoshi Kuwabara, Takanori Yokota, Kyoichi Nomura, Atsuro Chiba, Ryuji Kaji, Takashi Kanda, Ken-Ichi Kaida, Tatsuro Mutoh, Ryo Yamasaki, Hiroshi Takashima, Makoto Matsui, Kazutoshi Nishiyama, Gen Sobue, Susumu Kusunoki. Serum IgG anti-GD1a antibody and mEGOS predict outcome in Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry. 2020.10; 91 (12): 1339-1342. ( PubMed, DOI )

  94. Kishimoto Y, Nakagawa O, Fujii A, Yoshioka K, Nagata T, Yokota T, Hari Y, Obika S. 2',4'-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance*. Chemistry . 2020.10; 27 (7): 2427-2438. ( PubMed, DOI )

  95. Abe T, Yokota T, Fukushima A, Kakutani N, Katayama T, Shirakawa R, Maekawa S, Nambu H, Obata Y, Yamanashi K, Nakano I, Takada S, Yokota I, Okita K, Kinugawa S, Anzai T. Type 2 diabetes is an independent predictor of lowered peak aerobic capacity in heart failure patients with non-reduced or reduced left ventricular ejection fraction. Cardiovascular diabetology. 2020.09; 19 (1): 142. ( PubMed, DOI )

  96. Iwase R, Irioka T, Igarashi S, Ayabe J, Yokota T. Intracranial dural arteriovenous fistula mimicking neuromyelitis optica spectrum disorder: A case report. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2020.08; 29 (8): 105007. ( PubMed, DOI )

  97. Tai Otani, Takashi Irioka, Susumu Igarashi, Kimihiko Kaneko, Toshiyuki Takahashi, Takanori Yokota. Self-remitting cerebral cortical encephalitis associated with myelin oligodendrocyte glycoprotein antibody mimicking acute viral encephalitis: A case report. Mult Scler Relat Disord. 2020.06; 41 102033. ( PubMed, DOI )

  98. Kosei Hirata, Takaaki Hattori, Satoko Kina, Qingmeng Chen, Masahiro Ohara, Takanori Yokota. Striatal Dopamine Denervation Impairs Gait Automaticity in Drug-Naïve Parkinson's Disease Patients. Mov. Disord.. 2020.06; 35 (6): 1037-1045. ( PubMed, DOI )

  99. Ryo Iwase, Taro Ishiguro, Kyohei Fujita, Satoru Ishibashi, Takanori Yokota. Dupilumab for Atopic Dermatitis, a Possible Risk Factor of Juvenile Ischemic Stroke: A Case Report. J Stroke Cerebrovasc Dis. 2020.06; 29 (6): 104763. ( PubMed, DOI )

  100. Hirata K, Kobayashi M, Miyashita A, Yokota T. Steroid-responsive myositis in a patient with Sjögren's syndrome and refractory peripheral neuropathy. Neurological sciences . 2020.05; 41 (5): 1303-1305. ( PubMed, DOI )

  101. Jinbing Xie, Daniel Gonzalez-Carter, Theofilus A Tockary, Noriko Nakamura, Yonger Xue, Makoto Nakakido, Hiroki Akiba, Anjaneyulu Dirisala, Xueying Liu, Kazuko Toh, Tao Yang, Zengtao Wang, Shigeto Fukushima, Junjie Li, Sabina Quader, Kouhei Tsumoto, Takanori Yokota, Yasutaka Anraku, Kazunori Kataoka. Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain. ACS Nano. 2020.05; 14 (6): 6729-6742. ( PubMed, DOI )

  102. Masahiro Ohara, Takaaki Hattori, Takanori Yokota. Progressive supranuclear palsy often develops idiopathic normal pressure hydrocephalus-like MRI features. Eur. J. Neurol.. 2020.05; 27 (10): 1930-1936. ( PubMed, DOI )

  103. Teruhiko Sekiguchi, Satoru Ishibashi, Jo Sasame, Jun-Ichi Mukae, Kotaro Noda, Hiroaki Tanaka, Koh Yamamoto, Yasunori Takemoto, Jiro Kumagai, Takanori Yokota. Recurrent stroke due to quasi-moyamoya disease associated with POEMS syndrome: An autopsy case. J. Neurol. Sci.. 2020.02; 412 116738. ( PubMed, DOI )

  104. Nishida Y, Takahashi YK, Kanai T, Nose Y, Ishibashi S, Sanjo N, Uzawa A, Oda F, Ozawa Y, Kuwabara S, Noguchi E, Suzuki S, Nakahara J, Suzuki N, Ogawa T, Yokoyama K, Hattori N, Konno S, Fujioka T, Kawaguchi N, Hatanaka Y, Sonoo M, Kaneko J, Ogino M, Nishiyama K, Nomura K, Yokota T. Safety of tapering tacrolimus dose in patients with well-controlled anti-acetylcholine receptor antibody-positive myasthenia gravis. European journal of neurology. 2020.01; 27 (1): 100-104. ( PubMed, DOI )

  105. Lei Mon SS, Yoshioka K, Jia C, Kunieda T, Asami Y, Yoshida-Tanaka K, Piao W, Kuwahara H, Nishina K, Nagata T, Yokota T. Highly efficient gene silencing in mouse brain by overhanging-duplex oligonucleotides via intraventricular route. FEBS letters. 2020.01; 594 (9): 1413-1423. ( PubMed, DOI )

  106. Rintaro Iwata Hara, Kotaro Yoshioka, Takanori Yokota. DNA-RNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing. Methods Mol. Biol.. 2020; 2176 113-119. ( PubMed, DOI )

  107. Yanagidaira M, Nishida Y, Yokota T. Temporal correlation between serum CH<sub>50</sub> level and symptom severity of myasthenia gravis during eculizumab therapy. Clinical neurology and neurosurgery. 2019.12; 189 105630. ( PubMed, DOI )

  108. Masaki Ohyagi, Takashi Irioka, Takuya Ohkubo, Satoru Ishibashi, Yuko K Takahashi, Eiichiro Amano, Akira Machida, Hiroya Kuwahara, Takanori Yokota. Intrathecal IgG Synthesis and Persistent Inflammation Are Associated with White Matter Lesions in HIV-negative Patients with Cryptococcal Meningoencephalitis. Intern. Med.. 2019.11; 58 (21): 3077-3082. ( PubMed, DOI )

  109. Yanagidaira M, Hattori T, Emoto H, Kiyosawa M, Yokota T. Optic perineuritis with anti-myelin oligodendrocyte glycoprotein antibody. Multiple sclerosis and related disorders. 2019.10; 38 101444. ( PubMed, DOI )

  110. Ohara M, Sanjo N, Hattori T, Oyama J, Hamada M, Ozaki K, Yokota T. Olivary hypertrophy improved by steroid treatment: Two case reports with unique presentations. Journal of neuroimmunology. 2019.09; 334 577003. ( PubMed, DOI )

  111. Yoshioka K, Kunieda T, Asami Y, Guo H, Miyata H, Yoshida-Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Hara RI, Nagata T, Wada T, Obika S, Yokota T. Highly efficient silencing of microRNA by heteroduplex oligonucleotides. Nucleic acids research. 2019.08; 47 (14): 7321-7332. ( PubMed, DOI )

  112. Momoko Ebashi, Shuta Toru, Ayako Nakamura, Satoshi Kamei, Takanori Yokota, Katsuiku Hirokawa, Toshiki Uchihara. Detection of AD-specific four repeat tau with deamidated asparagine residue 279-specific fraction purified from 4R tau polyclonal antibody Acta Neuropathologica. 2019.07; 138 (1): 163-166.

  113. Fujita K, Tanaka K, Yamagami H, Ide T, Ishiyama H, Sonoda K, Satow T, Takahashi JC, Ihara M, Koga M, Yokota T, Toyoda K. Detrimental Effect of Chronic Hypertension on Leptomeningeal Collateral Flow in Acute Ischemic Stroke. Stroke. 2019.07; 50 (7): 1751-1757. ( PubMed, DOI )

  114. Shintaku H, Yamaguchi M, Toru S, Kitagawa M, Hirokawa K, Yokota T, Uchihara T. . Three-dimensional surface models of autopsied human brains constructed from multiple photographs by photogrammetry. PLoS One. 2019.07; 14 (7): ( DOI )

  115. Head and Neck Cancer Study Group (HNCSG), Monden N, Asakage T, Kiyota N, Homma A, Matsuura K, Hanai N, Kodaira T, Zenda S, Fujii H, Tahara M, Yokota T, Akimoto T, Iwae S, Onitsuka T, Ogawa T, Okano S, Takahashi S, Shimizu Y, Yonezawa K, Hayashi R. A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition). Japanese journal of clinical oncology. 2019.07; 49 (7): 589-595. ( PubMed, DOI )

  116. Otsu S, Ishibashi S, Ozaki K, Yokota T. Elevated lipid peaks during the recovery phase of Baló's concentric sclerosis: A case report. eNeurologicalSci. 2019.06; 15 100191. ( PubMed, DOI )

  117. Ono D, Shishido-Hara Y, Mizutani S, Mori Y, Ichinose K, Watanabe M, Tanizawa T, Yokota T, Uchihara T, Fujigasaki H. Development of demyelinating lesions in progressive multifocal leukoencephalopathy (PML): Comparison of magnetic resonance images and neuropathology of post-mortem brain. Neuropathology : official journal of the Japanese Society of Neuropathology. 2019.06; 39 (4): 294-306. ( PubMed, DOI )

  118. Hashiguchi S, Doi H, Kunii M, Nakamura Y, Shimuta M, Suzuki E, Koyano S, Okubo M, Kishida H, Shiina M, Ogata K, Hirashima F, Inoue Y, Kubota S, Hayashi N, Nakamura H, Takahashi K, Katsumoto A, Tada M, Tanaka K, Sasaoka T, Miyatake S, Miyake N, Saitsu H, Sato N, Ozaki K, Ohta K, Yokota T, Mizusawa H, Mitsui J, Ishiura H, Yoshimura J, Morishita S, Tsuji S, Takeuchi H, Ishikawa K, Matsumoto N, Ishikawa T, Tanaka F. Ataxic phenotype with altered Ca<sub>V</sub>3.1 channel property in a mouse model for spinocerebellar ataxia 42. Neurobiology of disease. 2019.06; 130 104516. ( PubMed, DOI )

  119. Guo L, Bertola DR, Takanohashi A, Saito A, Segawa Y, Yokota T, Ishibashi S, Nishida Y, Yamamoto GL, Franco JFDS, Honjo RS, Kim CA, Musso CM, Timmons M, Pizzino A, Taft RJ, Lajoie B, Knight MA, Fischbeck KH, Singleton AB, Ferreira CR, Wang Z, Yan L, Garbern JY, Simsek-Kiper PO, Ohashi H, Robey PG, Boyde A, Matsumoto N, Miyake N, Spranger J, Schiffmann R, Vanderver A, Nishimura G, Passos-Bueno MRDS, Simons C, Ishikawa K, Ikegawa S. Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation. American journal of human genetics. 2019.05; 104 (5): 925-935. ( PubMed, DOI )

  120. Uehara T, Choong CJ, Nakamori M, Hayakawa H, Nishiyama K, Kasahara Y, Baba K, Nagata T, Yokota T, Tsuda H, Obika S, Mochizuki H. Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease. Scientific reports. 2019.05; 9 (1): 7567. ( PubMed, DOI )

  121. Ozaki K, Ansai A, Nobuhara K, Araki T, Kubodera T, Ishii T, Higashi M, Sato N, Soga K, Mizusawa H, Ishikawa K, Yokota T. Prevalence and clinicoradiological features of spinocerebellar ataxia type 34 in a Japanese ataxia cohort. Parkinsonism & related disorders. 2019.05; 65 238-242. ( PubMed, DOI )

  122. Nico J. Diedrich, James Surmeier, Toshiki Uchihara, Sten Grillner, Christopher G. Goetz. Parkinson's disease: Is it a consequence of human brain evolution? Movement Disorders. 2019.04; ３４ (４): ４５３-1531. ( PubMed, DOI )

  123. Hirata K, Numasawa Y, Kobayashi Z, Yokota T. Bilateral Optic Tract Hyperintensity due to Pituitary Apoplexy. Internal medicine (Tokyo, Japan). 2019.04; 58 (8): 1185-1186. ( PubMed, DOI )

  124. Rashaun S. Wilson, Navin Rauniyar, Fumika Sakaue, TuKiet T. Lam, Kenneth R. Williams, Angus C. Nairn. Development of Targeted Mass Spectrometry-Based Approaches for Quantitation of Proteins Enriched in the Postsynaptic Density (PSD) proteomes. 2019.04; 7 (2): ( PubMed, DOI )

  125. Hashimoto S, Inaji M, Nariai T, Kobayashi D, Sanjo N, Yokota T, Ishii K, Taketoshi M. Usefulness of [<sup>11</sup>C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma. Neurologia medico-chirurgica. 2019.04; 59 (5): 176-183. ( PubMed, DOI )

  126. Ebashi M, Toru S, Nakamura A, Kamei S, Yokota T, Hirokawa K, Uchihara T. Detection of AD-specific four repeat tau with deamidated asparagine residue 279-specific fraction purified from 4R tau polyclonal antibody. Acta neuropathologica. 2019.04; 138 (1): 163-166. ( PubMed, DOI )

  127. Furukawa F, Ishikawa K, Yokota T, Sanjo N. Cross-Sectional Area Analysis of the Head of the Caudate Nucleus in Huntington's Disease. European neurology. 2019.04; 81 (1-2): 13-18. ( PubMed, DOI )

  128. Sanjo N, Nose Y, Shishido-Hara Y, Mizutani S, Sekijima Y, Aizawa H, Tanizawa T, Yokota T. A controlled inflammation and a regulatory immune system are associated with more favorable prognosis of progressive multifocal leukoencephalopathy. Journal of neurology. 2019.02; 266 (2): 369-377. ( PubMed, DOI )

  129. Suzuki S, Naito S, Numasawa Y, Asada M, Shoji N, Zeniya M, Takahashi D, Sato H, Iimori S, Nomura N, Sohara E, Okado T, Ishiwata Y, Nagata M, Rai T, Yokota T, Uchida S. Encephalopathy Induced by High Plasma and Cerebrospinal Fluid Ceftriaxone Concentrations in a Hemodialysis Patient. Internal medicine (Tokyo, Japan). 2019.02; 58 (12): 1775-1779. ( PubMed, DOI )

  130. Maeda Y, Iwata Hara R, Nishina K, Yoshida-Tanaka K, Sakamoto T, Yokota T, Wada T. Artificial cationic peptides that increase nuclease resistance of siRNA without disturbing RNAi activity. Nucleosides, nucleotides & nucleic acids. 2019.01; 38 (5): 338-348. ( PubMed, DOI )

  131. Amano E, Ozaki K, Ishibashi S, Sanjo N, Yokota T. Remarkable improvement in progressive multifocal leukoencephalopathy following acute pyelonephritis with bacteremia. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2019.01; 62 226-228. ( PubMed, DOI )

  132. Takahashi K, Yanai S, Takisawa S, Kono N, Arai H, Nishida Y, Yokota T, Endo S, Ishigami A. Vitamin C and vitamin E double-deficiency increased neuroinflammation and impaired conditioned fear memory. Archives of biochemistry and biophysics. 2019.01; 663 120-128. ( PubMed, DOI )

  133. Otani T, Irioka T, Takahashi YK, Soga K, Igarashi S, Kaneko K, Takahashi T, Yokota T. Two cases of late-onset neuromyelitis optica spectrum disorder initially presenting with isolated cerebral white matter lesions. eNeurologicalSci. 2018.12; 13 35-37. ( PubMed, DOI )

  134. Ozaki K, Ohkubo T, Yamada T, Yoshioka K, Ichijo M, Majima T, Kudo S, Akashi T, Honda K, Ito E, Watanabe M, Sekine M, Hamagaki M, Eishi Y, Sanjo N, Ishibashi S, Mizusawa H, Yokota T. Progressive Encephalomyelitis with Rigidity and Myoclonus Resolving after Thymectomy with Subsequent Anasarca: An Autopsy Case Internal Medicine. 2018.12; 57 (23): 3451-3458. ( ichushi )

  135. Miura M, Numasawa Y, Takahisa M, Ozaki K, Irioka T, Nishida Y, Ishibashi S, Yokota T. Levodopa-responsive truncal tremor in a patient with spinocerebellar ataxia type 3. Journal of the neurological sciences. 2018.09; 392 32-33. ( PubMed, DOI )

  136. Miho Akaza*, Itaru Akaza, Tadashi Kanouchi, Tetsuo Sasano, Yuki Sumi, Takanori Yokota. Nerve conduction study of the association between glycemic variability and diabetes neuropathy. Diabetology &Metabolic Syndrome. 2018.09; 10 69. ( PubMed, DOI )

  137. Zeniya S, Kuwahara H, Daizo K, Watari A, Kondoh M, Yoshida-Tanaka K, Kaburagi H, Asada K, Nagata T, Nagahama M, Yagi K, Yokota T. Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system. Journal of controlled release : official journal of the Controlled Release Society. 2018.08; 283 126-134. ( PubMed, DOI )

  138. Yokote H, Kamata T, Toru S, Sanjo N, Yokota T. Brain volume loss is present in Japanese multiple sclerosis patients with no evidence of disease activity. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2018.07; 39 (10): 1713-1716. ( PubMed, DOI )

  139. Honda T, Nagao S, Hashimoto Y, Ishikawa K, Yokota T, Mizusawa H, Ito M. Tandem internal models execute motor learning in the cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 2018.07; 115 (28): 7428-7433. ( PubMed, DOI )

  140. Ozaki K, Ohkubo T, Yamada T, Yoshioka K, Ichijo M, Majima T, Kudo S, Akashi T, Honda K, Ito E, Watanabe M, Sekine M, Hamagaki M, Eishi Y, Sanjo N, Ishibashi S, Mizusawa H, Yokota T. Progressive Encephalomyelitis with Rigidity and Myoclonus Resolving after Thymectomy with Subsequent Anasarca: An Autopsy Case. Internal medicine (Tokyo, Japan). 2018.07; 57 (23): 3451-3458. ( PubMed, DOI )

  141. Sasaguri H, Nagata K, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, Sato K, Kurup D, Yokota T, Saido TC. Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID. Nature communications. 2018.07; 9 (1): 2892. ( PubMed, DOI )

  142. Asada K, Ito K, Yui D, Tagaya H, Yokota T. Cytosolic Genomic DNA functions as a Natural Antisense. Scientific reports. 2018.06; 8 (1): 8551. ( PubMed, DOI )

  143. Li Fuying, Ishibashi Satoru, Iwasawa Eri, Suzuki Motohiro, Ichinose Keiko, Yokota Takanori. Upregulation of lipoprotein receptors on brain endothelial cells and neurons in the early phase of ischemic stroke in mice Journal of Medical and Dental Sciences. 2018.06; 65 (2): 59-71. ( ichushi )

  144. Itaya Sakiko, Kobayashi Zen, Ozaki Kokoro, Sato Nozomu, Numasawa Yoshiyuki, Ishikawa Kinya, Yokota Takanori, Matsuda Hiroshi, Shintani Shuzo. Spinocerebellar Ataxia Type 31 with Blepharospasm Internal Medicine. 2018.06; 57 (11): 1651-1654. ( ichushi )

  145. Misawa S, Kuwabara S, Sato Y, Yamaguchi N, Nagashima K, Katayama K, Sekiguchi Y, Iwai Y, Amino H, Suichi T, Yokota T, Nishida Y, Kanouchi T, Kohara N, Kawamoto M, Ishii J, Kuwahara M, Suzuki H, Hirata K, Kokubun N, Masuda R, Kaneko J, Yabe I, Sasaki H, Kaida KI, Takazaki H, Suzuki N, Suzuki S, Nodera H, Matsui N, Tsuji S, Koike H, Yamasaki R, Kusunoki S, Japanese Eculizumab Trial for GBS (JET-GBS) Study Group.. Safety and efficacy of eculizumab in Guillain-Barré syndrome: a multicentre, double-blind, randomised phase 2 trial. The Lancet. Neurology. 2018.06; 17 (6): 519-529. ( PubMed, DOI )

  146. Guo Huijia, Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Miyata Haruka, Yoshida-Tanaka Kie, Nagata Tetsuya, Yokota Takanori. Efficacy of microRNA silencing by lipid-conjugated double-stranded antisense oligonucleotides Journal of Medical and Dental Sciences. 2018.06; 65 (2): 83-88. ( ichushi )

  147. Iwasawa E, Ishibashi S, Suzuki M, Li F, Ichijo M, Miki K, Yokota T. Sphingosine-1-Phosphate Receptor 1 Activation Enhances Leptomeningeal Collateral Development and Improves Outcome after Stroke in Mice. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2018.05; 27 (5): 1237-1251. ( PubMed, DOI )

  148. Higashi M, Ozaki K, Hattori T, Ishii T, Soga K, Sato N, Tomita M, Mizusawa H, Ishikawa K, Yokota T. A diagnostic decision tree for adult cerebellar ataxia based on pontine magnetic resonance imaging. Journal of the neurological sciences. 2018.04; 387 187-195. ( PubMed, DOI )

  149. Hattori T, Ito K, Nakazawa C, Numasawa Y, Watanabe M, Aoki S, Mizusawa H, Ishiai S, Yokota T. Structural connectivity in spatial attention network: reconstruction from left hemispatial neglect. Brain imaging and behavior. 2018.04; 12 (2): 309-323. ( PubMed, DOI )

  150. Rintaro Iwata Hara, Yuki Hisada, Yusuke Maeda, Takanori Yokota, Takeshi Wada. Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs. Sci Rep. 2018.03; 8 (1): 4323. ( PubMed, DOI )

  151. Amano E, Ozaki K, Egawa S, Suzuki M, Hirai T, Ishibashi S, Ohkubo T, Yoshii T, Okawa A, Yokota T. Dynamic spinal compression revealed by computed tomography myelography in overshunting-associated myelopathy: A case report. Medicine. 2018.03; 97 (10): e0082. ( PubMed, DOI )

  152. Kuwahara H, Song J, Shimoura T, Yoshida-Tanaka K, Mizuno T, Mochizuki T, Zeniya S, Li F, Nishina K, Nagata T, Ito S, Kusuhara H, Yokota T. Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo. Scientific reports. 2018.03; 8 (1): 4377. ( PubMed, DOI )

  153. Hiroki Yamada, Takahiro Takeda, Toshiki Uchihara, Shizuko Sato, Susumu Kirimura, Yuka Hirota, Makoto Kodama, Masanobu Kitagawa, Katsuiku Hirokawa, Takanori Yokota, Shuta Toru. Macroscopic Localized Subicular Thinning as a Potential Indicator of Amyotrophic Lateral Sclerosis. Eur. Neurol.. 2018.03; 79 (3-4): 200-205. ( PubMed, DOI )

  154. Nishimaki K, Asada T, Ohsawa I, Nakajima E, Ikejima C, Yokota T, Kamimura N, Ohta S. Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Current Alzheimer research. 2018.03; 15 (5): 482-492. ( PubMed, DOI )

  155. Ito Y, Sanjo N, Hizume M, Kobayashi A, Ohgami T, Satoh K, Hamaguchi T, Yamada M, Kitamoto T, Mizusawa H, Yokota T. Biochemical features of genetic Creutzfeldt-Jakob disease with valine-to-isoleucine substitution at codon 180 on the prion protein gene. Biochemical and biophysical research communications. 2018.02; 496 (4): 1055-1061. ( PubMed, DOI )

  156. Furukawa F, Sanjo N, Kobayashi A, Hamaguchi T, Yamada M, Kitamoto T, Mizusawa H, Yokota T. Specific amyloid-β42 deposition in the brain of a Gerstmann-Sträussler-Scheinker disease patient with a P105L mutation on the prion protein gene. Prion. 2018; 12 (5-6): 315-319. ( PubMed, DOI )

  157. Hara Y, Mizobe Y, Miyatake S, Takizawa H, Nagata T, Yokota T, Takeda S, Aoki Y. Exon Skipping Using Antisense Oligonucleotides for Laminin-Alpha2-Deficient Muscular Dystrophy. Methods in molecular biology (Clifton, N.J.). 2018; 1828 553-564. ( PubMed, DOI )

  158. Yuko Yamagishi, Hidekazu Suzuki, Masahiro Sonoo, Satoshi Kuwabara, Takanori Yokota, Kyoichi Nomura, Atsuro Chiba, Ryuji Kaji, Takashi Kanda, Kenichi Kaida, Shu-Ichi Ikeda, Tatsuro Mutoh, Ryo Yamasaki, Hiroshi Takashima, Makoto Matsui, Kazutoshi Nishiyama, Gen Sobue, Susumu Kusunoki. Markers for Guillain-Barré syndrome with poor prognosis: a multi-center study. J. Peripher. Nerv. Syst.. 2017.12; 22 (4): 433-439. ( PubMed, DOI )

  159. Tetsuya Kanai, Akiyuki Uzawa, Yasunori Sato, Shigeaki Suzuki, Naoki Kawaguchi, Keiichi Himuro, Fumiko Oda, Yukiko Ozawa, Jin Nakahara, Norihiro Suzuki, Yuko K Takahashi, Satoru Ishibashi, Takanori Yokota, Takashi Ogawa, Kazumasa Yokoyama, Nobutaka Hattori, Shoko Izaki, Satoru Oji, Kyoichi Nomura, Juntaro Kaneko, Kazutoshi Nishiyama, Ichiro Yoshino, Satoshi Kuwabara. A clinical predictive score for postoperative myasthenic crisis. Ann. Neurol.. 2017.11; 82 (5): 841-849. ( PubMed, DOI )

  160. Yajun Hu, Yuji Hashimoto, Takashi Ishii, Mamut Rayle, Kazumasa Soga, Nozomu Sato, Michi Okita, Miwa Higashi, Kokoro Ozaki, Hidehiro Mizusawa, Kinya Ishikawa, Takanori Yokota. Sequence configuration of spinocerebellar ataxia type 8 repeat expansions in a Japanese cohort of 797 ataxia subjects. J. Neurol. Sci.. 2017.11; 382 87-90. ( PubMed, DOI )

  161. Shuta Toru, Tadashi Kanouchi, Takanori Yokota, Yosuke Yagi, Akira Machida, Takayoshi Kobayashi. Utility of Autonomic Function Tests to Differentiate Dementia with Lewy Bodies and Parkinson Disease with Dementia from Alzheimer Disease. Eur. Neurol.. 2017.11; 79 (1-2): 27-32. ( PubMed, DOI )

  162. Yuki Kishimoto, Akane Fujii, Osamu Nakagawa, Tetsuya Nagata, Takanori Yokota, Yoshiyuki Hari, Satoshi Obika. Synthesis and thermal stabilities of oligonucleotides containing 2'-O,4'-C-methylene bridged nucleic acid with a phenoxazine base. Org. Biomol. Chem.. 2017.10; 15 (38): 8145-8152. ( PubMed, DOI )

  163. Y Anraku, H Kuwahara, Y Fukusato, A Mizoguchi, T Ishii, K Nitta, Y Matsumoto, K Toh, K Miyata, S Uchida, K Nishina, K Osada, K Itaka, N Nishiyama, H Mizusawa, T Yamasoba, T Yokota, K Kataoka. Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nat Commun. 2017.10; 8 (1): 1001. ( PubMed, DOI )

  164. Nozomu Sato, Nozomi Toide, Mami Kizawa, Takuya Ohkubo, Satoru Ishibashi, Nobuo Sanjo, Takanori Yokota. Methotrexate-associated lymphoproliferative disorder in a patient with neuromyelitis optica spectrum disorder: An implication for pathogenesis mediated by Epstein-Barr virus. J. Neurol. Sci.. 2017.08; 379 219-221. ( PubMed, DOI )

  165. Ohyagi M, Ishibashi S, Ohkubo T, Kobayashi Z, Mizusawa H, Yokota T, Emoto H, Kiyosawa M. Subacute Supranuclear Palsy in anti-Hu Paraneoplastic Encephalitis. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 2017.07; 44 (4): 444-446. ( PubMed, DOI )

  166. Yokote H, Kamata T, Toru S, Sanjo N, Yokota T. Serum retinol levels are associated with brain volume loss in patients with multiple sclerosis. Multiple sclerosis journal - experimental, translational and clinical. 2017.07; 3 (3): 2055217317729688. ( PubMed, DOI )

  167. Taro Ishiguro, Nozomu Sato, Morio Ueyama, Nobuhiro Fujikake, Chantal Sellier, Akemi Kanegami, Eiichi Tokuda, Bita Zamiri, Terence Gall-Duncan, Mila Mirceta, Yoshiaki Furukawa, Takanori Yokota, Keiji Wada, J. Paul Taylor, Christopher E. Pearson, Nicolas Charlet-Berguerand, Hidehiro Mizusawa, Yoshitaka Nagai, and Kinya Ishikawa. Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31. Neuron. 2017.04; 94 (1): 108-124. ( PubMed, DOI )

  168. Numasawa Y, Hattori T, Ishiai S, Kobayashi Z, Kamata T, Kotera M, Ishibashi S, Sanjo N, Mizusawa H, Yokota T. Depressive disorder may be associated with raphe nuclei lesions in patients with brainstem infarction. Journal of affective disorders. 2017.04; 213 191-198. ( PubMed, DOI )

  169. Higuma M, Sanjo N, Mitoma H, Yoneyama M, Yokota T. Whole-Day Gait Monitoring in Patients with Alzheimer's Disease: A Relationship between Attention and Gait Cycle. Journal of Alzheimer's disease reports. 2017.04; 1 (1): 1-8. ( PubMed, DOI )

  170. Yokota Takanori. 肝外臓器におけるDNA/RNAヘテロ二本鎖オリゴヌクレオチド(HDO)の作用(The effect of DNA/RNA heteroduplex oligonucleotide (HDO) in extrahepatic organs) Journal of Pharmacological Sciences. 2017.03; 133 (3Suppl.): S43. ( ichushi )

  171. Kazumasa Soga, Kinya Ishikawa, Tokuro Furuya, Tadatsune Iida, Tetsuo Yamada, Noboru Ando, Kiyobumi Ota, Hiromi Kanno-Okada, Shinya Tanaka, Masayuki Shintaku, Yoshinobu Eishi, Hidehiro Mizusawa, Takanori Yokota. Gene dosage effect in spinocerebellar ataxia type 6 homozygotes: A clinical and neuropathological study. J Neurol Sci. 2017.02; 373 321-328. ( PubMed, DOI )

  172. Sakiko Chikazawa, Takaaki Hanafusa, Kokoro Ozaki, Takeshi Namiki, Maki Amano, Makiko Ueno, Shown Tokoro, Ken Igawa, Takefumi Sato, Kinya Ishikawa, Takanori Yokota, Hiroo Yokozeki. Incomplete Behçet's disease with calf muscle pain and MRI hyperintensity due to possible thrombophlebitis. Eur J Dermatol. 2017.02; 27 (1): 76-77. ( PubMed, DOI )

  173. Keisuke Abe, Takuya Ohkubo, Takanori Yokota.. TDP-43 in the skin of amyotrophic lateral sclerosis patients. Journal of Medical and Dental Sciences. 2017.01; 64 (1): 9-17. ( PubMed, DOI )

  174. Yagi Y, Ohkubo T, Kawaji H, Machida A, Miyata H, Goda S, Roy S, Hayashizaki Y, Suzuki H, Yokota T. Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes. Neuroscience letters. 2017.01; 636 48-57. ( PubMed, DOI )

  175. Iwasawa E, Ohkubo T, Kanouchi T, Kanda T, Mizusawa H, Yokota T. Long-term Effects of Intravenous Cyclophosphamide in Combination with Mesna Provided Intravenously and via Bladder Perfusion in a Patient with Severe Multifocal Motor Neuropathy. Internal medicine (Tokyo, Japan). 2017; 56 (14): 1893-1896. ( PubMed, DOI )

  176. Nobutaka Ishizu, Daishi Yui, Akira Hebisawa, Hidenori Aizawa, Wanpeng Cui, Yuko Fujita, Kenji Hashimoto, Itsuki Ajioka, Hidehiro Mizusawa, Takanori Yokota, Kei Watase. Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice. Hum. Mol. Genet.. 2016.10; 25 (20): 4507-4517. ( PubMed, DOI )

  177. Ryo Yamasaki, Takuya Matsushita, Toshiyuki Fukazawa, Kazumasa Yokoyama, Kazuo Fujihara, Mieko Ogino, Takanori Yokota, Katsuichi Miyamoto, Masaaki Niino, Kyoichi Nomura, Ryo Tomioka, Masami Tanaka, Izumi Kawachi, Takashi Ohashi, Ken-Ichi Kaida, Makoto Matsui, Yuji Nakatsuji, Hirofumi Ochi, Hikoaki Fukaura, Takashi Kanda, Akiko Nagaishi, Kanae Togo, Hidehiro Mizusawa, Hiroyuki Murai, Jun-Ichi Kira. Efficacy of intravenous methylprednisolone pulse therapy in patients with multiple sclerosis and neuromyelitis optica. Mult. Scler.. 2016.09; 22 (10): 1337-1348. ( PubMed, DOI )

  178. Eri Iwasawa, Masahiko Ichijo, Satoru Ishibashi, Takanori Yokota. Acute development of collateral circulation and therapeutic prospects in ischemic stroke. Neural Regen Res. 2016.03; 11 (3): 368-371. ( PubMed, DOI )

  179. Enomoto M, Hirai T, Kaburagi H, Yokota T. Efficient Gene Suppression in Dorsal Root Ganglia and Spinal Cord Using Adeno-associated Virus Vectors Encoding Short-Hairpin RNA. Methods Mol Biol. 2016; 1364 277-290.

  180. Yamada K, Kobayashi H, Bo R, Takahashi T, Purevsuren J, Hasegawa Y, Taketani T, Fukuda S, Ohkubo T, Yokota T, Watanabe M, Tsunemi T, Mizusawa H, Takuma H, Shioya A, Ishii A, Tamaoka A, Shigematsu Y, Sugie H, Yamaguchi S. Clinical, biochemical and molecular investigation of adult-onset glutaric acidemia type II: Characteristics in comparison with pediatric cases. Brain Dev. 2016; 38 (3): 293-301.

  181. Yutaro Asami, Kotaro Yoshioka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. Drug delivery system of therapeutic oligonucleotides. Drug Discov Ther. 2016; 10 (5): 256-262. ( PubMed, DOI )

  182. M Ichijo, E Iwasawa, Y Numasawa, K Miki, S Ishibashi, M Tomita, H Tomimitsu, T Kamata, H Fujigasaki, S Shintani, H Mizusawa. Significance of Development and Reversion of Collaterals on MRI in Early Neurologic Improvement and Long-Term Functional Outcome after Intravenous Thrombolysis for Ischemic Stroke. AJNR Am J Neuroradiol. 2015.10; 36 (10): 1839-1845. ( PubMed, DOI )

  183. Yoneyama M, Mitoma H, Higuma M, Sanjo N, Yokota T, Terashi H. Ambulatory Gait Behavior in Patients with Dementia: A Comparison with Parkinson's Disease. IEEE Trans Neural Syst Rehabil Eng. 2015.09;

  184. Nakamaura Y, Ae R, Takumi I, Sanjo N, Kitamoto T, Yamada M, Mizusawa H. Descriptive epidemiology of prion disease in Japan: 1999-2012. J Epidemiol. 2015; 25 (1): 8-14.

  185. Hattori T, Arai A, Yokota T, Imadome K, Tomimitsu H, Miura O, Mizusawa H. Immune-mediated Neuropathy with Epstein-Barrvirus-positive T-cell Lymphoproliferative Disease. Intern Med. 2015; 54 (1): 69-73.

  186. Yoshioka K, Watanabe K, Zeniya S, Ito Y, Hizume M, Kanazawa T, Tomita M, Ishibashi S, Miake H, Tanaka H, Yokota T, Mizusawa H. A Score for Predicting Paroxysmal Atrial Fibrillation in Acute Stroke Patients: iPAB Score. J Stroke Cerebrovasc Dis. 2015; 24 (10): 2263-2269.

  187. Ozaki K, Doi H, Mitsui J, Sato N, Iikuni Y, Majima T, Yamane K, Irioka T, Ishiura H, Doi K, Morishita S, Higashi M, Sekiguchi T, Koyama K, Ueda N, Miura Y, Miyatake S, Matsumoto N, Yokota T, Tanaka F, Tsuji S, Mizusawa H, Ishikawa K. A Novel Mutation in ELOVL4 Leading to Spinocerebellar Ataxia (SCA) With the Hot Cross Bun Sign but Lacking Erythrokeratodermia: A Broadened Spectrum of SCA34. JAMA Neurol. 2015; 72 (7): 797-805.

  188. Mizutani S, Usui N, Yokota T, Mizusawa H, Taira M, Katsuyama N. Depth perception from moving cast shadow in macaque monkey. Behav Brain Res. 2015; 288 63-70.

  189. Hashimoto Y, Honda T, Matsumura K, Nakao M, Soga K, Katano K, Yokota T, Mizusawa H, Nagao S, Ishikawa K. Quantitative evaluation of human cerebellum-dependent motor learning through prism adaptation of hand-reaching movement. PLoS One. 2015; 10 (3): e0119376.

  190. Yokote H, Nose Y, Ishibashi S, Tanaka K, Takahashi T, Fujihara K, Yokota T, Mizusawa H. Spinal cord ring enhancement in patients with neuromyelitis optica. Acta Neurol Scand. 2015; 132 (1): 37-41.

  191. Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wenby RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 2015; 18 (4): 521-530.

  192. Aikawa T, Mogushi K, Iijima-Tsutsui K, Ishikawa K, Sakurai M, Tanaka H, Mizusawa H, Watase K. Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model. Hum Mol Genet. 2015; 24 (17): 4780-4791.

  193. Pedroso JL, Abrahao A, Ishikawa K, Raskin S, de Souza PV, de Rezende Pinto WB, Braga-Neto P, de Albuquerque MV, Mizusawa H, Barsottini OG. When should we test patients with familial ataxias for SCA31? A misdiagnosed condition outside Japan? J Neurol Sci. 2015; 355 (1-2): 206-208.

  194. Ohmori H, Hara A, Ishikawa K, Mizusawa H, Ando Y. Clinical characteristics of combined cases of spinocerebellar ataxia types 6 and 31. J Neurogenet. 2015; 29 (2-3): 80-4.

  195. Mitsui J, Matsukawa T, Sasaki H, Yabe I, Matsushima M, Dürr A, Brice A, Takashima H, Kikuchi A, Aoki M, Ishiura H, Yasuda T, Date H, Ahsan B, Iwata A, Goto J, Ichikawa Y, Nakahara Y, Momose Y, Takahashi Y, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Ito M, Sobue G, Ishikawa K, Mizusawa H, Kanai K, Hattori T, Kuwabara S, Arai K, Koyano S, Kuroiwa Y, Hasegawa K, Yuasa T, Yasui K, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Kusunoki S, Osaki Y, Horiuchi M, Kondo T, Murayama S, Hattori N, Yamamoto M, Murata M, Satake W, Toda T, Filla A, Klockgether T, Wüllner U, Nicholson G, Gilman S, Tanner CM, Kukull WA, Stern MB, Lee VM, Trojanowski JQ, Masliah E, Low PA, Sandroni P, Ozelius LJ, Foroud T, Tsuji S. Variants associated with Gaucher disease in multiple system atrophy. Ann Clin Transl Neurol. 2015; 2 (4): 417-426.

  196. Ozaki K, Irioka T, Ishikawa K, Mizusawa H. CADASIL with a novel NOTCH3 mutation (Cys478Tyr). J Stroke Cerebrovasc Dis. 2015; 24 (3): e61-62.

  197. Nishida Y, Ueda A, Ando Y, Ichikawa T. Skin biopsy-based diagnosis of CADASIL with atypical MRI findings. Intern Med. 2015; 54 (5): 537-538.

  198. Takenouchi T, Ohyagi M, Torii C, Kosaki R, Takahashi T, Kosaki K. Porencephaly in a fetus and HANAC in her father: variable expression of COL4A1 mutation. Am J Med Genet A. 2015; 167A (1): 156-158.

  199. Echigoya Y, Aoki Y, Miskew B, Panesar D, Touznik A, Nagata T, Tanihata J, Nakamura A, Nagaraju K, Yokota T. Long-term efficacy of systemic multiexon skipping targeting dystrophin exons 45-55 with a cocktail of vivo-morpholinos in mdx52 mice. Mol Ther Nucleic Acids. 2015; 4 e225.

  200. Kimura K, Morita H, Daimon M, Kawata T, Nakao T, Lee SL, Hirokawa M, Ebihara A, Nakajima T, Ozawa T, Yonemochi Y, Aida I, Motoyoshi Y, Mikata T, Uchida I, Komori T, Kitao R, Nagata T, Takeda S, Komaki H, Segawa K, Takenaka K, Komuro I . Prognostic impact of venous thromboembolism in patients with Duchenne muscular dystrophy: Prospective multicenter 5-year cohort study. Int J Cardiol. 2015; 191 178-180.

  201. Masaki Y, Inde T, Nagata T, Tanihata J, Kanamori T, Seio K, Takeda S, Sekine M. Enhancement of exon skipping in mdx52 mice by 2’-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides. Med Chem Commun. 2015; 6 630-633.

  202. Colangelo CM, Ivosev G, Chung L, Abbott T, Shifman M, Sakaue F, Cox D, Kitchen RR, Burton L, Tate SA, Gulcicek E, Bonner R, Rinehart J, Nairn AC, Williams KR. Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins. Proteomics. 2015; 15 (7): 1202-1214.

  203. Yagi Y, Yokote H, Watanabe Y, Amino T, Kamata T, Kusunoki S. Taste impairment in Miller Fisher syndrome. Neurol Sci. 2015; 36 (5): 809-810.

  204. Ozaki K, Sanjo N, Ishikawa K, Higashi M, Hattori T, Tanuma N, Miyata R, Hayashi M, Yokota T, Okawa A, Mizusawa H. Elevation of 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of three patients with superficial siderosis. Neurol Clin Neurosci. 2015; 3 (3): 108-110.

  205. Ohyagi M, Nakamura K, Watanabe M, Fujigasaki H. Embolic stroke during apixaban therapy for left atrial appendage thrombus. J Stroke Cerebrovasc Dis. 2015; 24 (4): e101-102.

  206. Ishibashi K, Miura Y, Ishikawa K, Ishii K, Ishiwata K. Decreased metabotropic glutamate receptor type 1 availability in a patient with spinocerebellar ataxia type 6: A (11)C-ITMM PET study. J Neurol Sci. 2015; 355 (1-2): 202-205.

  207. Yabe I, Matsushima M, Yoshida K, Ishikawa K, Shirai S, Takahashi I, Sasaki H. Rare frequency of downbeat positioning nystagmus in spinocerebellar ataxia type 31. J Neurol Sci. 2015; 350 (1-2): 90-92.

  208. Obayashi M, Stevanin G, Synofzik M, Monin ML, Duyckaerts C, Sato N, Streichenberger N, Vighetto A, Desestret V, Tesson C, Wichmann HE, Illig T, Huttenlocher J, Kita Y, Izumi Y, Mizusawa H, Schöls L, Klopstock T, Brice A, Ishikawa K, Dürr A. Spinocerebellar ataxia type 36 exists in diverse populations and can be caused by a short hexanucleotide GGCCTG repeat expansion. J Neurol Neurosurg Psychiatry. 2015; 86 (9): 986-995.

  209. Iwata R, Nakayama F, Hirochi S, Sato K, Piao W, Nishina K, Yokota T, Wada T. Synthesis and properties of vitamin E analog-conjugated neomycin for delivery of RNAi drugs to liver cells. Bioorg Med Chem Lett. 2015; 25 (4): 815-819.

  210. Azuma R, Ishikawa K, Hirata K, Hashimoto Y, Takahashi M, Ishii K, Inaba A, Yokota T, Orimo S. A novel mutation of PDE8B Gene in a Japanese family with autosomal-dominant striatal degeneration. Mov Disord. 2015; 30 (14): 1964-1967.

  211. Yui D, Nishida Y, Nishina T, Mogushi K, Tajiri M, Ishibashi S, Ajioka I, Ishikawa K, Mizusawa H, Murayama S, Yokota T. Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme. PLoS One. 2015; 10 (12): e0143518.

  212. Murakami M, Nishina K, Watanabe C, Yoshida-Tanaka K, Piao W, Kuwahara H, Horikiri Y, Miyata K, Nishiyama N, Kataoka K, Yoshida M, Mizusawa H, Yokota T. Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route. Sci Rep. 2015; 5 17035.

  213. Nishina K, Piao W, Yoshida-Tanaka K, Sujino Y, Nishina T, Yamamoto T, Nitta K, Yoshioka K, Kuwahara H, Yasuhara H, Baba T, Ono F, Miyata K, Miyake K, Seth PP, Low A, Yoshida M, Bennett CF, Kataoka K, Mizusawa H, Obika S, Yokota T. DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. Nat Commun. 2015; 6 7969.

  214. Nishina T, Numata J, Nishina K, Yoshida-Tanaka K, Nitta K, Piao W, Iwata R, Ito S, Kuwahara H, Wada T, Mizusawa H, Yokota T. Chimeric Antisense Oligonucleotide Conjugated to α- Tocopherol. Mol Ther Nucleic Acids. 2015; 4 e220.

  215. Masahiko Ichijo, Satoru Ishibashi, Fuying Li, Daishi Yui, Kazunori Miki, Hidehiro Mizusawa, Takanori Yokota. Sphingosine-1-Phosphate Receptor-1 Selective Agonist Enhances Collateral Growth and Protects against Subsequent Stroke. PLoS ONE. 2015; 10 (9): e0138029. ( PubMed, DOI )

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