Conference Activities & Talks -

1. Yokota Takanori. （Chairs）NFS-01 Neuroscience Frontier Symposium 01「Exploring Early Clinical Development through Innovative Drug Modalities」. 第65回日本神経学会学術大会 2024.05.29 東京

2. Matsubayashi Taiki, Ae Ryusuke, Kosami Koki, Tsukamoto Tadashi, Satoh Katsuya, Hamaguchi Tsuyoshi, Furukawa Fumiko, Takao Masaki, Kitamoto Tetsuyuki, Nakamura Yosikazu, Mizusawa Hidehiro, Yamada Masahito, Yokota Takanori, Sanjo Nobuo. PRNP遺伝子にP105L変異を認めるプリオン病の臨床病理学的解析(Clinicopathological analysis in prion disease with PRNP P105L mutation). Dementia Japan 2023.10.01

3. Ishihara Tomohiko, Ikenaka Kensuke, Takahashi Yuji, Yokota Takanori, Ishikawa Kinya, Hirano Makito, Nagai Yoshitaka, Onodera Osamu. AJA030-002　ポリグルタミン病に対するタンパク質凝集阻害剤の第II相試験(AJA030-002:Phase II Study of a Protein Aggregation Inhibitor for Polyglutamine Disease). 臨床神経学 2023.09.01

4. Ichinose Keiko, Li Fuying, Ishibashi Satoru, Iwasawa Eri, Suzuki Motohiro, Yoshida Kie, Yoshioka Kotaro, Nagata Tetsuya, Mogushi Kaoru, Yokota Takanori. 脂質結合DNA/RNAヘテロ2本鎖オリゴヌクレオチドの急性虚血脳への効果的な送達(Effective delivery of lipid conjugated DNA/RNA heteroduplex oligonucleotide to acute ischemic brain). 臨床神経学 2023.09.01

5. 常 詩晨, 田中 敏博, 稲澤 譲治, 水澤 英洋, 三條 伸夫, 横田 隆徳, 石川 欽也. 神経疾患の遺伝的リスク評価. 臨床神経学 2023.09.01

6. Yokota Takanori. 神経疾患に関する遺伝子治療と細胞療法　神経疾患を標的としたDNA/RNAヘテロ2本鎖オリゴヌクレオチド(Gene and cell therapy for neurological diseases　DNA/RNA heteroduplex oligonucleotides for neurological diseases). 臨床神経学 2023.09.01

7. Hattori Takaaki, Kitsuka Narumi, Sanjo Nobuo, Oyama Jun, Yoshii Toshitaka, Okawa Atsushi, Yokota Takanori. 硬膜閉鎖後の表在性シデローシスにおける前側頭葉の逆説的なMRI増悪(Paradoxical MRI exacerbation in anterior temporal lobe in superficial siderosis after dural closure). 臨床神経学 2023.09.01

8. Ono Daisuke, Kawai Honami, Kuwahara Hiroya, Yokota Takanori. 機械学習アプリケーションによる腓腹神経生検の自動whole slide解析(Automated Whole Slide Analysis of Sural Nerve Biopsy by Machine Learning Application). 臨床神経学 2023.09.01

9. Miura Motoki, Sakaue Fumika, Matsuno Hirokazu, Morita Kento, Hara Rintaro, Yokota Takanori. 核酸結合によるTDP-43の空間分布を介した溶解性の制御(Regulation of TDP-43 solubility via its spatial organization by nucleic acid binding). 臨床神経学 2023.09.01

10. Yokote Hiroaki, Miyazaki Yusei, Toru Shuta, Nishida Yoichiro, Hattori Takaaki, Niino Masaaki, Sanjo Nobuo, Yokota Takanori. 日本人多発性硬化症患者の脳容積減少を抑制する有効性の高い治療法(High-efficacy therapy reduces brain volume loss in Japanese patients with multiple sclerosis). 臨床神経学 2023.09.01

11. Kuroda Takayuki, Yoshioka Kotaro, Su Su Lei Mon , Sakamoto Toshihiro, Katsuyama Maho, Yoshida-Tanaka Kie, Iwata-Hara Rintaro, Yamaguchi Takao, Nagata Tetsuya, Obika Satoshi, Yokota Takanori. アンチセンスオリゴヌクレオチドの神経毒性を克服するための化学的改良の開発(Development of chemical modifications to overcome neurotoxicity of antisense oligonucleotide). 臨床神経学 2023.09.01

12. Iwase Ryo, Ishiguro Taro, Hasegawa Juri, Iwata Hara Rintaro, Nagata Tetsuya, Yokota Takanori. RNA-DNAヘテロG4構造誘導ASOを用いたDMDエクソンスキッピングに対する新戦略(A new strategy for DMD exon skipping with RNA-DNA hetero-G4 structure inducing ASOs). 臨床神経学 2023.09.01

13. Yanagidaira Mitsugu, Nagata Testuya, Hasegawa Juri, Ishii Satoshi, Ebihara Satoe, Yokota Takanori. PMO/RNAヘテロ2本鎖を用いたCNSにおけるスプライス制御の新規技術(Novel technology for splice modulation in CNS by PMO/RNA heteroduplex). 臨床神経学 2023.09.01

14. Amano Eiichiro, Raveney Ben, Yokota Takanori, Yamamura Takashi, Oki Shinji. NRP-1+Th細胞はCD11c+B細胞を増殖させ脳反応性自己抗体の強力な供給源となる(NRP-1+Th cells expand CD11c+B cells that are potent source of brain reactive autoantibodies). 臨床神経学 2023.09.01

15. Yokota T. Blood-Brain-Barrier(BBB)penetrating DNA/RNA Heteroduplex Oligonucleotide regulating CNS genes by systemic administration. ANA2022 2022.10.23 CHICAGO

16. Yokota T. Blood-Brain-Barrier penetrating DNA/RNA Heteroduplex Oligonuclotide (HDO)can regulate genes of microglia and lymphocytes by systemic administration. The 34th annual meeting of the Japanese Society for Neuroimmunology 2022.10.21 長崎

17. Hirata Kosei, Matsuoka Kiwamu, Tagai Kenji, Endo Hironobu, Kokubo Naomi, Tatebe Harutsugu, Zhang Hong, Shinotoh Hitoshi, Takahata Keisuke, Ono Maiko, Obata Takayuki, Kawamura Kazunori, Zhang Ming-Rong, Shimada Hitoshi, Tokuda Takahiko, Yokota Takanori, Takado Yuhei, Higuchi Makoto. タウオパチーにおけるアストロサイトに関連した脳エネルギー代謝の変化(Altered brain energy metabolism related to astrocytes in tauopathies). 臨床神経学 2022.10.01

18. Sano Tatsuhiko, Nagata Tetsuya, Ebihara Satoe, Yoshida-Tanaka Kie, Mochizuki Hideki, Hasegawa Masato, Yokota Takanori. ASOの局所投与はマウスにおける異常αシヌクレイン病態の伝播を防ぐ(Local administration of ASO prevents the propagation of abnormal α-synuclein pathology in mice). 臨床神経学 2022.10.01

19. Amano Eiichiro, Sato Wakiro, Yamaguchi Hiromi, Yokota Takanori, Yamamura Takashi. 視神経脊髄炎患者におけるCD11chigh B細胞の増加(CD11chigh B cell expansion in patients with neuromyelitis optica). 臨床神経学 2022.10.01

20. Okamoto Tomoko, Sato Wakiro, Lin Youwei, Shimizu Yuko, Nishida Yoichiro, Yokota Takanori, Ishizuka Takami, Nakamura Harumasa, Takahashi Yuji, Yamamura Takashi. 糖脂質OCH-NCNP1　多発性硬化症患者を対象とした第II相臨床試験プロトコール(Glycolipid OCH-NCNP1: Protocol of Phase II Clinical Trial for Patients with Multiple Sclerosis). 臨床神経学 2022.10.01

21. Ishihara Tomohiko, Ikenaka Kensuke, Takahashi Yuji, Yokota Takanori, Ishikawa Kinya, Hirano Makito, Nagai Yoshitaka, Onodera Osamu. ポリグルタミン病に対するタンパク質凝集阻害剤の第II相試験(Phase II Study of a Protein Aggregation Inhibitor for Polyglutamine Disease). 臨床神経学 2022.10.01

22. Sanjo Nobuo, Amano Akiko, Araki Wataru, Anraku Yasutaka, Nakakido Makoto, Matsubara Etsuro, Hirata Kousei, Nagata Tetsuya, Tsumoto Kouhei, Kataoka Kazunori, Yokota Takanori. ナノミセル化抗アミロイドβオリゴマー断片抗体のAD病態における有効性(Efficacy of nanomicelle-encapsulated anti-amyloid β oligomer fragment antibody in AD pathology). 臨床神経学 2022.10.01

23. Kawabata Sakino, Toide Nozomi, Nagata Tetsuya, Yoshida-Tanaka Kie, Ihara Kensuke, Yokota Takanori. トリコサン酸結合DNA/RNAヘテロ二重鎖オリゴヌクレオチドはマウスの筋において非常に効率的である(Tricosanoic acid conjugated DNA/RNA heteroduplex oligonucleotide is highly efficient in mouse muscle). 臨床神経学 2022.10.01

24. Hasegawa Juri, Nagata Tetsuya, Ihara Kensuke, Tanihata Jun, Yokota Takanori. エクソンスキッピングの新しい治療法としての脂質結合ヘテロ二重鎖オリゴヌクレオチドの開発(Development of Lipid-conjugated heteroduplex oligonucleotide as a new treatment for exon skipping). 臨床神経学 2022.10.01

25. Higashi Miwa, Okita Michi, Sato Nozomu, Aoki Hanako, Komatsu Takumi, Asaka Meiko, Yanagihara Dai, Yokota Takanori, Ishikawa Kinya. SCA31ペンタヌクレオチド反復配列BACトランスジェニックマウスの運動表現型(Motor phenotype of BAC transgenic mice with SCA31 pentanucleotide repeats). 臨床神経学 2022.10.01

26. Aoki Hanako, Higashi Miwa, Okita Michi, Ishikawa Kinya, Yokota Takanori. Pentanucleotide repeat(TTCCA)nによるSCA31の小脳におけるTK2の発現と機能(Expression and function of TK2 in the cerebellum of SCA31 caused by pentanucleotide repeat (TTCCA)n). 臨床神経学 2022.10.01

27. Nishi Rieko, Ohyagi Masaki, Nagata Tetsuya, Mabuchi Yo, Yokota Takanori. DNA/RNAヘテロ二重鎖オリゴヌクレオチドによる活性化ミクログリアとマクロファージの制御(Regulation of activated microglia and macrophages by DNA/RNA heteroduplex oligonucleotides). 臨床神経学 2022.10.01

28. Aoki H,Higashi M,Okita M,Ishikawa K,Yokota T. Expression and function of TK2 in the cerebellum of SCA31 caused by pentanucleotide repeat (TTCCA). 第６３回日本神経学会学術大会 2022.05.20 東京

29. Higashi M,Okita M,Sato N,Aoki H,Komatsu T,Asaka M,Yanagihara D,Yokota T,Ishikawa K. Motor phenotype of BAC transgenic mice with SCA31 pentanucleotide repeats. 第６３回日本神経学会学術大会 2022.05.20 東京

30. Sanjo N,Amano A,Araki W,Anraku Y,Nakakido M,Matsubara EHirata K,Nagata T,Tsumoto K,Kataoka K,Yokota T,. Efficacy of nanomicelle-encapsulated anti-amyloid β oligomer fragment antibody in AD pathology. 第６３回日本神経学会学術大会 2022.05.19 東京

31. Kawabata S,Toide N,Nagata T,Yoshida-tanaka K,Ihara K,Yokota T,. Tricosanoic acid conjugated DNA/RNA heteroduplex oligonucleotide is highly efficient in mouse muscle. 第６３回日本神経学会学術大会 2022.05.19 東京

32. Amano E,Sato W,Yamaguchi H,Yokota T,Yamamura T. CD11chigh B cell expansion in patients with neuromyelitis optica. 第６３回日本神経学会学術大会 2022.05.19 東京

33. Ishihara T,Ikenaka K,Takahashi Y,Yokota T,Ishikawa K,Hirano M,Nagai Y,Onodera O. Phase Ⅱ study of a Protein Aggregation Inhibitor for Polyglutamine Disease. 第６３回日本神経学会学術大会 2022.05.19 東京

34. Nishi R,Ohyagi M,Nagata T,Mabuchi Y,Yokota T. Regulation of activated microglia and macrophages by DNA/RNA heteroduplex oligonucleotides. 第６３回日本神経学会学術大会 2022.05.18 東京

35. Hirata K,Matsuoka K,Tagai K,Endo H,Kokubo N,Tatebe H,Zhang H,Shinotoh H,Takahata K,Ono M,Obata T,Kawamura K,Zhang M,Shimada H,Tokuda T,Yokota T,Takado Y,Higuchi M. Aitered brain energy metabolism related to astrocytes in tauopathies. 第６３回日本神経学会学術大会 2022.05.18 東京

36. Hasegawa J,Nagata T,Ihara K,Tanihata J,Yokota T. Development of Lipid-conjugated heteroduplex oligonucleotide as a new treatment for exon skipping. 第６３回日本神経学会学術大会 2022.05.18 東京

37. Sano T,Nagata T,Ebihara S,Yoshida-tanaka K,Mochizuki H,Hasegawa M,Yokota T. Local administration of ASO prevents the propagation of abnormal α-synuclein pathology in micein pathology in mice. 第６３回日本神経学会学術大会 2022.05.18 東京

38. Tamaki Kana, Nishida Yoichiro, Sanjo Nobuo, Yokota Takanori. A patient with generalized myasthenia gravis facing an impending crisis triggered by early fast-acting treatment. Clinical and Experimental Neuroimmunology 2022.05.01

39. Noda K, Nosaka N, Hara N, Yokota T, Shigemitsu H, Takahashi H. We Should Pay Attention to "Referred Pain": A Case of Acute Myocardial Infarction That Masked and Delayed the Diagnosis of Esophageal Perforation. Internal Medicine 2022.04.01

40. 中村圭佑,金澤俊郎,関口輝彦,桑原宏哉,石川欽也,横田隆徳,西野一三,大久保卓哉. DNM2遺伝子新規変異を認めた中心核ミオパチーが疑われる76歳女性例. 2022.03.05

41. 大谷 泰,赤座実穂,叶内 匡,夏井洋和,川端茂徳,渡部泰士,石田洸樹,宮野由貴,足立善昭,関原謙,横田隆徳. 生体磁場計測装置を用いた単一の運動単位の電気活動評価. 第14回CBIR/ONSA/大学院セミナー共済　若手インスパイアシンポジウム 2022.02.17

42. Ohara M,Nagata T,Iwata Hara R,Takagi K,Sato K,Maeda Y,Wada T,Yokota T. Cationic oligopeptides enhance the therapeutic potential of ligand-conjug DNA/RNA heteroduplex . 第14回CBIR/ONSA/大学院セミナー共済　若手インスパイアシンポジウム 2022.02.17

43. Takanori Yokota. Development of heteroduplex oligonucleotides(HDO)for contral nervous system by systemic administration. PACIFICHEM 2021 2021.12.17 USA　web

44. Takaaki Hattori, Masahiro Ohara, Tatsuhiko Yuasa, Reo Azuma, Qingmeng Chen, Satoshi Orimo, Takanori Yokota. Callosal angle at splenium is phenotypicmarker of idiopathic normal pressure hydrocephalus. The 15th Congress of the Movement Disorder Society of Japan 2021.07.02

45. Shinya Akiko, Takahashi Makoto, Sato Nozomu, Nishida Yoichiro, Inaba Akira, Inaji Motoki, Yokota Takanori, Orimo Satoshi. 髄腔内バクロフェン療法が成功した痙性不全対麻痺として現れた眼・歯・指異形成症(Oculo-dento-digital Dysplasia Presenting as Spastic Paraparesis Which Was Successfully Treated by Intrathecal Baclofen Therapy). Internal Medicine 2021.07.01

46. Chunyan Jia，Kotaro Yoshioka，Su Su Lei Mon，Maho Katsuyama，Kie Tanaka-yoshida，Tetsuya Nagata，Takanori Yokota. Hetereoduplex oligonucleotiede mitigates various types of acute CNS toxicities via CSF route. 62nd Annual Meeting of the Japanese Society of Neurology  2021.05.21 Kyoto

47. Yurie Nose，Ikuko Uwano，Ukihide Tateishi，Makoto Sasaki，Takanori Yokota，Nobuo Sanjo. Clinical and radiological efficacy of deferiprone in post-operative superficial siderosis. 62nd Annual Meeting of the Japanese Society of Neurology  2021.05.20 Kyoto

48. Taiki Matsubayashi，Takaaki Hattori，Masahiro Ohara，Kosei Hirata，Qingmeng Chen，Sato ko Kina，Koji Morito，Kaoru Shimano，Takanori Yokota. Dopaminergic denervation in executive striatum predicts response to L-dopa in Parkinson's disease. 62nd Annual Meeting of the Japanese Society of Neurology  2021.05.20 Kyoto

49. Masahiro Ohara，Takaaki Hattori，Taiki Matsubayashi，Kosei Hirata，Qingmeng Chen，Satoko Kina，Koji Morito，Kaoru Shimano，Takanori Yokota. Inter-regional balance within striatum affects cognition and dual-task gait in Parkinson's disease. 62nd Annual Meeting of the Japanese Society of Neurology  2021.05.20 Kyoto

50. Takaaki Hattori, Richard Reynolds, Silvina Horovitz, Codrin Lungu, Eric Wassermann, Mark Hallett. Decreased functional integrity within striatum and sensorimotor network in Parkinson disease. 62nd Annual Meeting of the Japanese Society of Neurology  2021.05.20 Kyoto

51. Su Su Lei Mon，Kotaro Yoshioka，Chunyan Jia，Taiki Kunieda，Yutaro Asami，Kie Yoshida-tanaka，Wenying Piao，Hiroya Kuwahara，Kazutaka Nishina，Tetsuya Nagata，Takanori Yokota. Overhanging duplex oligonucleotide enhances potency and mitigates toxicity intracerebroventricularly. 62nd Annual Meeting of the Japanese Society of Neurology  2021.05.19 Kyoto

52. Motoki Miura，Fumika Sakaue，Taro Ishiguro，Ryo Iwase，Tatsuhiko Sano，Rintaro Hara，Takeshi Wada，Tetsuya Nagata，Takanori Yokota. TDP-43-specific aptamer rescues ALS phenotype in TDP-43 transgenic mice. 62nd Annual Meeting of the Japanese Society of Neurology  2021.05.19 Kyoto

53. Miwa Higashi，Michi Okita，Hanako Aoki，Takashi Ishii，Tetsuya Nagata，Taro Ishiguro，Takanori Yokota，Kinya Ishikawa. What are the roles of TGGAA penta-nucleotide repeats as bidirectional transcripts in SCA31?. 62nd Annual Meeting of the Japanese Society of Neurology  2021.05.19 Kyoto

54. Hanako Aoki，Miwa Higashi，Michi Okita，Takanori Yokota，Kinya Ishikawa. Expression of thymidine kinase 2 gene in human SCA31 cerebellum. 62nd Annual Meeting of the Japanese Society of Neurology  2021.05.19 Kyoto

55. Ishikawa K,Higashi M,Okita M,Aoki H,Asaka M,Ishiguro T,Sato N,Nagai Y,Yanagihara D,Yokota T. Pathogenesis of spinocerebellar ataxia type31(SCA31). 61st Annual Meeting of the Japanese Society of Neurology 2020.09.02 Okayama

56. Iwase R,Sanjo N,Ishiguro T,Yokota T. Clinical characteristics and pathophysiology of a rare muscle atrophy in superficial siderosis. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31 Okayama

57. Higashi M,Okita M,Sato N,Asaka M,Ishii T,Aoki H,Ishiguro T,Yanagihara D,Yokota T.Ishikawa K. SCA31 transgenic mice show pathologic features similar to human patients. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31 Okayama

58. Ohyagi M,Nagata T,Ihara K,Nishi R,Mabuchi Y,Akazawa C,Yokota T. New therapeutics strategy for multiple sclerosis by DNA/RNA heteroduplex oligonucleotide technology. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31 Okayama

59. Irioka T,Motomura M,Igarahi S,Takahahi Y,Iwase R,Otani T,Kitanosono H,Shiraihi H,Iizuka T,Yokota T. Calcium channels antibody-associated paraneoplastic disorders other than Lambert-Eaton syndrome. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31 Okayama

60. Asami Y,Nagata T,Yoshioka K,Kunieda T,Yoshida-Tanaka K,Yokota T. Efficient gene suppression by DNA/DNA double-stranded oligonucleotide in vivo. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31

61. Sano T,Nagata T,Tanaka K,Ebihara S,Mochizuki H,Hasegawa M,Yokota T. Inhibition of SNCA Propagation by locally injected ASO in wt mice. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31

62. Akaza M,Kawabata S,Watanabe T,Miyano Y,Mizuguchi R,Kaminaka S,Iida S,Sasaki T,Adachi Y,Sekihara K,Sumi Y,Okawa A,Yokota . The evaluation of nerve activity using magnetic field measurement and positional information by US. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31 Okayama

63. Nishi R,Ohyagi M,Nagata T,Mabuchi Y,Yokota T. DNA/RNA heteroduplex oligonucleotide technology for regulating activated microglia and macrophages. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31

64. Yokote H,Toru S,Nishida Y,Hattori T,Sanjo N,Yokota T. Association between serum amyloid A and cortical volume in patients with multiple sclerosis. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31 Okayama

65. Aoki H,Higashi M,Okita M,Yokota T,Ishikawa K. Expression of thymidine kinase 2 and mitochondrial proteins in SCA31 human brains. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31 Okayama

66. Ohara M,Takagi K,Yoshida K,Maeda Y,Hara R,Sato K,Nagata T,Wada T,Yokota T. Development of antidote for therapeutic oligonucleotides which reduces the acute toxicity. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31

67. Jia C,Yoshioka K,Lei Mon S,Tanaka K,Nagata T,Yokota T. Heteroduplex Oligonucleotides technology improves therapeutic index for CNS diseases. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31

68. Maruoka H,Hattori T,Orimo S,Yokota T. Graph theoretical analysis of structural brain network of Alzheimer's disease patients. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31 Okayama

69. Yoshioka K,Kunieda T,Asami Y,Tanaka K,Piao W,Kuwahara H,Nishina K,Nagata T,Yokota T. Treatment for FAP with overhanging heteroduplex oligonucleotides by transferrin-mediated delivery. 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31 Okayama

70. Yokota T,Nagata T,Dwyer C,Yoshida K,Yoshioka K,Seth P,Rigo F,Bennett F. Development of BBB-penetrating heteroduplex oligonucleotides(HDO). 61st Annual Meeting of the Japanese Society of Neurology 2020.08.31 Okayama

71. Takanori Yokota. New Stage of DNA/RNA Heteroduplex Oligonucleotide. Asia TIDES:Oligonucleotide & Peptide Therapeutics 2020.02.24 kyoto

72. Kotaro Yoshioka. Heteroduplex-Oligonucleotides　for　Highly　Efficient　Silencing　of　microRNA　through　a　Novel　intracellular Mechanism. 2019　Oligonucleotides　Meeting 2019.11.16 Munich

73. Takanori Yokota. Systemically Administered DNA/RNA Heteroduplex Oligonucleotides That Can Efficiently Regulate CNS Genes*. TIDES Europe2019:Oligonucleotide &Peptide Therapeutics 2019.11.13 Amsterdam

74. Amano A,Sanjo N,Nakakido M,Tsumoto K,Matsubara E,Furukawa F,Nishida Y,Saito T,Saido T,Yokota T,. Quantitative evaluation of Aβ oligomer in mouse brain using dot blot method. 第38回日本認知症学会学術集会 2019.11.07 新宿

75. Otani Tai, Iwase Ryo, Takahashi Yuko K., Soga Kazumasa, Kim Yangsu, Igarashi Susumu, Kaneko Kimihiko, Takahashi Toshiyuki, Irioka Takashi, Yokota Takanori. MOG抗体陽性中枢神経疾患の多様性(A Variety of Myelin Oligodendrocyte Glycoprotein Antibody Positive Central Nervous System Disorders). 臨床神経学 2019.11.01

76. Yokota Takanori. トランスレーショナルリサーチ後の時代における運動ニューロン疾患　ALS治療のオリゴヌクレオチド薬(Motor neuron diseases in the era after translational research　Oligonucleotide drug for treatment of ALS). 臨床神経学 2019.11.01

77. Ishiguro Taro, Yokota Takanori, Ishikawa Kinya, Nagai Yoshitaka, Petrucelli Leonard. ショウジョウバエのSpt4ノックダウンはSCA31関連の伸長UGGAAリピート誘発毒性を抑制する(Spt4 knockdown suppressed SCA31-linked expanded UGGAA repeat-induced toxicity in Drosophila). 臨床神経学 2019.11.01

78. Irioka Takashi, Motomura Masakatsu, Uchihara Toshiki, Shintaku Hiroshi, Ishikawa Kinya, Igarashi Susumu, Majima Takamasa, Takahashi Yuko K., Iwase Ryo, Otani Tai, Kitanosono Hiroko, Shiraishi Hirokazu, Tsuura Yukio, Yokota Takanori. カルシウムチャネル抗体関連小脳失調症患者の臨床病理学的研究(Clinicopathological study of a patient with calcium channels antibody-associated cerebellar ataxia). 臨床神経学 2019.11.01

79. Sanjo Nobuo, Shishido-Hara Yukiko, Nose Yurie, Yokota Takanori. 疾患修飾療法時代の進行性多巣性白質脳症　炎症の制御と免疫システムの制御はPMLの良好な予後と関連している(Progressive multifocal leukoencephalopathy in the era of disease-modifying therapies　A controlled inflammation and a regulatory immune system are associated with better prognosis of PML). 臨床神経学 2019.11.01

80. Iwase Ryo, Irioka Takashi, Takahashi Yuko K., Igarashi Susumu, Otani Tai, Soga Kazumasa, Yokota Takanori. 血管内リンパ腫(IVL)3症例の臨床および神経放射線学的研究(Clinical and neuroradiological study of 3 patients with intravascular lymphoma(IVL)). 臨床神経学 2019.11.01

81. Kim Yangsu, Iwase Ryo, Otani Tai, Igarashi Susumu, Soga Kazumasa, Irioka Takashi, Yokota Takanori. 血液透析患者における水痘・帯状疱疹ウイルス脳炎後の帯状疱疹(Varicella-zoster virus encephalitis followed by herpes zoster in hemodialysis patients). 臨床神経学 2019.11.01

82. Akaza Miho, Kawabata Shigenori, Watanabe Taishi, Hasegawa Yuki, Iida Shintaro, Sasaki Toru, Adachi Yoshiaki, Sekihara Kensuke, Kanouchi Tadashi, Sumi Yuki, Okawa Atsushi, Yokota Takanori. 脊磁計によるC8神経根症の診断(Diagnosis of C8 radiculopathy by magnetospinogram). 臨床神経学 2019.11.01

83. Hirata Kosei, Hattori Takaaki, Chen Qingmeng, Ohara Masahiro, Kina Satoko, Yokota Takanori. 線条体でのドーパミン枯渇とパーキンソン病患者におけるストライド長の変動との相関(Striatal dopamine depletion correlates with variability of stride length in Parkinson's disease). 臨床神経学 2019.11.01

84. 高橋 直, 宮本 翔平, 三條 伸夫, 横田 隆徳. 第三脳室幅は慢性進行型神経ベーチェット病の高感度マーカーである(Width of the third ventricle is high-sensitive marker for chronic progressive neuro-Behcet's disease). 臨床神経学 2019.11.01

85. Yokota T. BBB-penetrating DNA/RNA heteroduplex oligonucleotide efficiently regulating CNS gene. Tokyo Medical and Dental University-Taipei Medical University Joint Symposium on Medical Innovation 2019.10.05 Taipei

86. Taiki Matsubayashi, Miho Akaza, Nobuo Sanjo, Tsuyoshi Hamaguchi, Yuichi Hayashi, Takayoshi Shimohata, Masahito Yamada, Takanori Yokota. Focal sharp waves are specific in the early stage of MM2 cortical form of sCJD . Asian Pacific Prion Symposium 2019 2019.10.03 埼玉

87. Amano Akiko, Sanjo Nobuo, Nakakido Makoto, Tsumoto Kouhei, Matsubara Etsuro, Furukawa Fumiko, Nishida Yoichiro, Saito Takashi, Saido Takaomi, Yokota Takanori. ドットブロット法を用いたマウス脳におけるAβオリゴマーの定量的評価(Quantitative evaluation of Aβ oligomer in mouse brain using dot blot method). Dementia Japan 2019.10.01

88. Takaaki Hattori. Neural correlates of compensatory process and impaired working memory in Parkinson’s disease during disease progression. 23rd International Congress of Parkinson's Disease and Movement Disrders 2019.09.25 Nice

89. 天野晶子,三條伸夫,仲木戸誠,津本浩平,松原悦朗,古川迪子,西田陽一郎,斉藤貴志,西道隆臣,横田隆徳. ドットブロット法を用いたマウス脳中アミロイドβオリゴマーの定量法評価. 第7回日本アミロイドーシス学会学術集会 2019.08.30 東京

90. Ono Daisuke, Shishido-Hara Yukiko, Mizutani Saneyuki, Mori Yoko, Ichinose Keiko, Watanabe Mutsufusa, Tanizawa Tohru, Yokota Takanori, Uchihara Toshiki, Fujigasaki Hiroto. 進行性多巣性白質脳症(PML)における脱髄病変の発症　死後脳MRIと神経病理の比較(Development of demyelinating lesions in progressive multifocal leukoencephalopathy(PML): Comparison of magnetic resonance images and neuropathology of post-mortem brain). NEUROPATHOLOGY 2019.08.01

91. Amano A,Sanjo N,Nakakido M,Tsumoto K,Matsubara E,Nishida Y,Hattori T,Nagata T,Tomiyama T,Yokota T. Quantitative measurement of amyloid-beta oligomer in mouse brain using dot blot assay. ALZHEIMER'S ASSOCIATION INTERNATIONAL CONFERENCE2019 2019.07.16 LOS ANGELES

92. Iwase Ryo, Irioka Takashi, Takahashi Yuko K, Igarashi Susumu, Otani Tai, Soga Kazumasa, Yokota Takanori. Clinical and neuroradiological study of 3 patients with intravascular lymphoma(IVL). 第60回日本神経学会学術大会 2019.05.25

93. Otani Tai, Iwase Ryo, Takahashi Yuko K, Soga Kazumasa, Kim Yangsu, Igarashi Susumu, Kaneko Kimihiko, Takahashi Toshiyuki, Irioka Takashi, Yokota Takanori. A Variety of Myelin Oligodendrocyte Glycoprotein Antibody Positive Central Nervous System Disorders. 第60回日本神経学会学術大会 2019.05.25

94. Sanjo Nobuo, Shishido-hara Yukiko, Nose Yurie, Yokota Takanori. Progressive multifocal leukoencephalopathy in the era of disease-modifying therapies　A controlled inflammation and a regulatory immune system are associated with better prognosis of PML. 第60回日本神経学会学術大会 2019.05.25

95. Yokota Takanori. Oligonucleotide drug for treatment of ALS. 第６０回日本神経学会学術大会 2019.05.25

96. 高橋 直, 宮本 翔平, 三條 伸夫, 横田 隆徳. Width of the third ventricle is high-sensitive marker for chronic progressive neuro-Behcet's disease. 第60回日本神経学会学術大会 2019.05.25

97. Hirata Kosei, Hattori Takaaki, Chen Qingmeng, Ohara Masahiro, Kina Satoko, Yokota Takanori. Striatal dopamine depletion correlates with variability of stride length in Parkinson's disease. 第60回日本神経学会学術大会 2019.05.24

98. Irioka Takashi, Motomura Masakatsu, Uchihara Toshiki, Shintaku Hiroshi, Ishikawa Kinya, Igarashi Susumu, Majima Takamasa, Takahashi Yuko K, Iwase Ryo, Otani Tai, Kitanosono Hiroko, Shiraishi Hirokazu, Tsuura Yukio, Yokota Takanori. Clinicopathological study of a patient with calcium channels antibody-associated cerebellar ataxia. 第60回日本神経学会学術大会 2019.05.24

99. Ishiguro Taro, Yokota Takanori, Ishikawa Kinya, Nagai Yoshitaka, Petrucelli Leonard. Spt4 knockdown suppressed SCA31-linked expanded UGGAA repeat-induced toxicity in Drosophila. 第60回日本神経学会学術大会 2019.05.24

100. Kim Yangsu, Iwase Ryo, Otani Tai, Igarashi Susumu, Soga Kazumasa, Irioka Takashi, Yokota Takanori. Varicella-zoster virus encephalitis followed by herpes zoster in hemodialysis patients. 第60回日本神経学会学術大会 2019.05.24

101. Igarashi S,Otani T,Soga K,Irioka T,Kuhara T,Ozai K,Yokota T. Peri-insular sign:An MRI finding on acute fulminant hyperammonemia caused by a urea cycle disorder. 第60回日本神経学会学術大会 2019.05.23 大阪

102. Yokote H,Amano R,Toru S,Hattori T,Nishida Y,Sanjo N,Yokota T. Brain atrophy is associated with higher serum amyloid A levels in patients with multiple sclerosis. 第60回日本神経学会学術大会 2019.05.23 大阪

103. Yoshioka K,Lei Mon S,Jia C,Yamada H,Asami Y,Tanaka K,Wenying P,Kuwahara H,Nishina K,Nagata T,Yokota T. A novel antisense oligonucleotide terapy by overhanging heteroduplex oligonucleotide targeting CNS. 第60回日本神経学会学術大会 2019.05.23 大阪

104. Akaza Miho, Kawabata Shigenori, Watanabe Taishi, Hasegawa Yuki, Iida Shintaro, Sasaki Toru, Adachi Yoshiaki, Sekihara Kensuke, Kanouchi Tadashi, Sumi Yuki, Okawa Atsushi, Yokota Takanori. Diagnosis of C8 radiculopathy by magnetospinogram. 第60回日本神経学会学術大会 2019.05.23

105. Yagi Y, Iida S, Kanouchi T, Kusunoki S, Sobue G, Kaji R, Kuwabara S, Yokota T, Glovenin-I CIDP Study Group. Maintenance treatment with IVIg for CIDP can prevent disease progression. 第60回日本神経学会学術大会 2019.05.22 Osaka

106. Ishibashi S,Li F,Iwasawa E,Suzuki M,Ichinose K,Yokota T. Upregulation of lipoprotein receptors on brain in the early phase of ischemic stroke in mice. 第60回日本神経学会学術大会 2019.05.22 大阪

107. New DNA/RNA heteroduplex oligonucleotide technology for regulating functions of lymphocytes in vivo. 第60回日本神経学会学術大会 2019.05.22 大阪

108. Zeniya S,Kuwahara H,Daizo K,Watari A,Kondo M,Yoshida-Tanaka K,Kaburagi H,Asada K,Nagata T,Nagahama M,Yagi K,Yokota T.. BBB-crossing drug delivery system by modulating tight junction at brain microvascular endothelium. 第６０回日本神経学会学術大会 2019.05.22 大阪

109. Takahashi YK,Nishida Y,Nose Y,Ishibashi S,Sanjo N,Kanai T,Uzawa A,Oda F,Ozawa Y,Kuwabara S,Yokota T. Calcineurin inhibitors can be safely reduced in most patients with well-controlled myasthenia gravis. American Academy of Neurology(AAN)71st Annual Meeting 2019.05.06 Philadelphia

110. Hashimoto Satoka, Inaji Motoki, Nariai Tadashi, Kobayashi Daisuke, Sanjo Nobuo, Yokota Takanori, Ishii Kenji, Maehara Taketoshi. 高グレード星細胞腫とtumefactive multiple sclerosisを鑑別するための[11C]Methionine PETの有用性(Usefulness of [11C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma). Neurologia medico-chirurgica 2019.05.01

111. 八木洋輔,横田隆徳. Small RNA profiling of cerebrospinal fluid exosomes. 第6回JMACシンポジウム 2019.01.24 東京

112. Shintaku Hiroshi, Yamaguchi Mari, Toru Syuuta, Kitagawa Masanobu, Hirokawa Katsuiku, Uchihara Toshiki, Yokota Takanori. 2D画像からの3D表面再構成　ヒト剖検脳への適用(3-dimensional surface reconstruction from 2-dimensional images. Application to human autopsied brain). 臨床神経学 2018.12.01

113. Sanjo Nobuo, Shishido-Hara Yukiko, Nose Yurie, Ono Daisuke, Sekijima Yoshiki, Yokota Takanori. 中枢神経系の炎症性JCウイルス感染時におけるPD-1の保護作用(Protective effect of PD-1 during inflammatory JC virus infection of the central nervous system). 臨床神経学 2018.12.01

114. Uehara Takuya, Choong Chi-Jing, Nakamori Masayuki, Nishiyama Kumiko, Hayakawa Hideki, Kasahara Yuuya, Baba Kousuke, Nagata Tetsuya, Yokota Takanori, Tsuda Hiroshi, Obika Satoshi, Mochizuki Hideki. α-synucleinを標的とする新たなアンチセンスオリゴヌクレオチドはパーキンソンモデルマウスの運動機能を改善する(A new antisense oligos targeting alpha-synuclein improves motor function in Parkinson's model mouse). 臨床神経学 2018.12.01

115. Ishibashi Satoru, Iwasawa Eri, Suzuki Motohiro, Li Fuying, Ichijo Masahiko, Miki Kazunori, Yokota Takanori. S1P1活性化は軟髄膜の側副路発達を増強して脳卒中後のアウトカムを改善する(S1P1 activation enhances leptomeningeal collateral development and improves outcome after stroke). 臨床神経学 2018.12.01

116. Akaza Miho, Akaza Itaru, Kanouchi Tadashi, Sasano Tetsuo, Sumi Yuki, Yokota Takanori. 血糖値変動とNCSで評価した糖尿病性ニューロパチーとの関連性の検討(Study for association between glycemic variability and diabetic neuropathy assessed by NCS). 臨床神経学 2018.12.01

117. Ichijo Masahiko, Ishibashi Satoru, Miki Kazunori, Sugita Yoichiro, Itaya Sakiko, Amino Takeshi, Kamata Tomoyuki, Yokota Takanori. 静脈内rt-PA投与下のMCA閉塞患者における出血性変化の予測因子(Predictors of Hemorrhagic Transformation in Patients with MCA occlusion Receiving intravenous rt-PA). 臨床神経学 2018.12.01

118. Ohara Masahiro, Hattori Takaaki, Ishibashi Satoru, Sanjo Nobuo, Yokota Takanori. 進行性核上性麻痺患者は特発性正常圧水頭症様のMRI所見を有する(Progressive supranuclear palsy has idiopathic normal pressure hydrocephalus like MRI features). 臨床神経学 2018.12.01

119. Zen Kobayashi, Miho Yoshioka, Keisuke Inoue, Mayumi Watanabe, Kaori Kato, Kazunori Toyoda, Yoshiyuki Numasawa, Shoichiro Ishihara, Hiroyuki Tomimitsu, Shuzo Shintani. Serial changes in Trail Making Test score after mild ischemic stroke. The 20th Congress of the International Association of Rural Health and Medicine 2018.10.11 Tokyo

120. Keisuke Inoue, Yoshiyuki Numasawa, Satoshi Sutou, Masaki Hakomori, Kazunori Toyoda, Hiroyuki Tomimitsu. The combination of Berg Balance Scale and Moss Attention Rating Scale for assessment of walking independence in acute ischemic stroke. The 20th Congress of the International Association of Rural Health and Medicine 2018.10.11 Tokyo

121. Takanori Yokota. Glycemic Control Boosts Glucosylated Nanocarrier Crossing the BBB into the Brain. The Oligo Meeting 2018 2018.10.03 Seatle

122. Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Kie Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Shingo Ito, Tetsuya Nagata, Takanori Yokota. Overhanging heteroduplex oligonucleotides enable enhanced gene silencing by efficient delivery associated with transferrin. The 2018　Oligo Meeting, 14th Annual Meeting of the Oligonucleotide Therapeutics Society 2018.10.01 USA

123. Satoshi Zeniya,Hiroya Kuwahara, Kaiichi Daizo, Akihiro Watari, Masuo Kondoh, Kie Yoshida-Tanaka,Hidetoshi Kaburagi, Ken Asada, Tetsuya Nagata, Masahiro Nagahama, Kiyohito Yagi, Takanori Yokota. Angubindin-1 for an efficient in vivo delivery of antisense oligonucleotide across the blood-brain barrier into brain. The 2018　Oligo Meeting, 14th Annual Meeting of the Oligonucleotide Therapeutics Society 2018.10.01 USA

124. Hiroya Kuwahara, Yasutaka Anraku, Kazunori Kataoka, Takanori Yokota. An efficient drug delivery system across the BBB by utilizing glycemic control. 第41回日本神経科学大会 2018.07.28 神戸

125. Akiko Amano, Nobuo Sanjo,Makoto Nakakido,Kouhei Tsumoto,Etsuro Matsubara,Fumiko Furukawa,Tetsuya Nagata,Yoichiro Nishida,Hiroya Kuwahara,kosei Hirata,Hiroyuki Maruoka,Takanori Yokota. Dot Blot Assay For Quantitative Measurement of Amyloid-Beta Oligomer. AAIC 2018 2018.07.22 USA

126. Nobuo Sanjo, Hiroya Kuwahara, Tetsuya Nagata, Yoichiro Nishida, Akiko Amano,Fumiko Furukawa, Kousei Hirata, Hiroyuki Maruoka, Makoto Nakakido, Tsumoto Kohei, Yasutaka Anraku, Kazunori Kataoka, Ichio Aoki, Etsuro Matsubara,Takami Tomiyama, Takanori Yokota. Morecular Imaging And Treatment of Alzheimer's Disease By Developing Amyloid-β oligomer Antibodies That Cross The Blood-Brain Barrier. AAIC 2018 2018.07.22 USA

127. Takanori Yokota. Glycemic control enables glucosylated nanocarrier crossing the BBB into the brain. 日本核酸医薬学会　第4回年会 2018.07.11 福岡

128. Su Su Lei Mon,Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Wenying Piao, Kie Tanaka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota . A novel structure of double-stranded heteroduplex oligonucleotides for intracerebroventricular application. 日本核酸医薬学会　第4回年会 2018.07.10 福岡

129. Takanori Yokota,Hiroya Kuwahara, Takahiro Shimoura, Jindong Song,Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Kazutaka Nishina, Tetsuya Nagata,Hiroyuki Kusuhara,　. Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo. Keystone Symposia 2018.06.20 USA

130. 横田隆徳. Development of blood-brain barrier-crossing amyloid-beta oligomer antibody. 第59回日本神経学会学術大会 2018.05.25 北海道

131. Hiroya Kuwahara、Takanori Yokota. BBB-crossing delivery mechanism of glucosylated nanocarrier by glycemic control. 第59回日本神経学会学術大会 2018.05.25 札幌

132. Su Su Lei Mon,Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Wenying Piao, Kie Tanaka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. A novel structure of duplex antisense oligonucleotides improves potency via intraventricular route. 第59回日本神経学会学術大会 2018.05.24 札幌

133. Kotaro Yoshioka, Takanori Yokota. A new class of double-stranded oligonucleotide enhances in vivo potency of microRNA silencing. 第59回日本神経学会学術大会 2018.05.23 札幌

134. Tetsuya Nagata、Takanori Yokota. Recent progress of DNA/RNA heteroduplex oligonucleotide. 第59回日本神経学会学術大会 2018.05.23 札幌

135. Hiroya Kuwahara、Takanori Yokota. Glyccemic Control Boosts Glucosylated Nanocarrier Crossing the BBB into the Brain. AAN2018 2018.04.22

136. Noriko Nakamura, Yasutaka Anraku, Hiroya Kuwahara, Takanori Yokota, Kazunori Kataoka. Development of innovative therapeutic nanomachines for intractable neurological diseases. 3rd COINS International Symposium 2016.12.15 Kawasaki

137. Takanori Yokota. DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. 3rd International Conference on Biomaterials Science. 2016.11.30 Tokyo

138. Yohsuke Yagi, Takuya Ohkubo, Hideya Kawaji, Akira Machida, Haruka Miyata, Saori Goda, Sugata Roy, Yoshihide Hayashizaki, Harukazu Suzuki, Takanori Yokota. Small RNA profiling of cerebrospinal fluid exosomes using next-generation sequencing. American Society for Exosomes and Microvesicles 2016 2016.10.21 California

139. Kotaro Yoshioka, Yumiko Sujino, Taiki Kunieda, Kie Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. Intracellular mechanisms of microRNA inhibition by a new double-stranded structure for therapeutic oligonucleotide. 12th Annual Meeting of the Oligonucleotide Therapeutics Society 2016.09.27 Montreal

140. Takanori Yokota. DNA/RNA heteroduplex oligonucleotide. 12th Annual Meeting of the Oligonucleotide Therapeutics Society 2016.09.27 Montreal

141. Taiki Kunieda, Kotaro Yoshioka, Yumiko Sujino, Kie Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. Pharmacokinetic study of double stranded antisense oligonucleotide: Hetero Chimera Duplex Oligonucleotide (HCDO). 12th Annual Meeting of the Oligonucleotide Therapeutics Society 2016.09.26 Montreal

142. Takanori Yokota. Propagation of TDP-43 in ALS. Propagation in Neurodegenerative Disease Conference 2016 2016.08.11 Dublin

143. Yoichiro Nishida, Daishi Yui, Tomoko Nishina, Kaoru Mogushi, Satoru Ishibashi, Itsuki Ajioka, Kinya Ishikawa, Hidehiro Mizusawa, Shigeo Murayama, Takanori Yokota. Enhanced Pla2g3 expression by oxidative stress decreases the IDE and exacerbates AD. Alzheimer's Association International Conference 2016 2016.07.26 Toronto

144. Fumiko Furukawa, Nobuo Sanjo, Atsushi Kobayashi, Tsuyoshi Hamaguchi, Masahito Yamada, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Takanori Yokota. Colocalization of Aβ42 with PrPSc-plaques in the brain of the Gerstmann-Sträussler-Scheinker disease with the P105L mutation. Alzheimer's Association International Conference 2016 2016.07.24 Toronto

145. Kazutaka Nishina, Kie Yoshida-Tanaka, Wenying Piao, Takanori Yokota. DNA/RNA heteroduplex oligonucleotide (HDO) for highly efficient gene silencing. The RNA society of Japan 18th annual meeting (The 21st annual meeting of the RNA society) 2016.06.30 Kyoto

146. Taiki Kunieda, Kotaro Yoshioka, Yumiko Sujino, Kie Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. Development of antisense oligonucleotide with a new type of a double stranded structure. The RNA society of Japan 18th annual meeting (The 21st annual meeting of the RNA society) 2016.06.29 Kyoto

147. Fumika Sakaue, Eiji Yasuda, Tatsuhiko Sano, Taro Ishiguro, Tetsuya Nagata, Takanori Yokota. Chemically modified RNAs inhibit TDP-43 aggregation. The RNA society of Japan 18th annual meeting (The 21st annual meeting of the RNA society) 2016.06.29 Kyoto

148. Kotaro Yoshioka, Yumiko Sujino, Taiki Kunieda, Kie Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. A new mechanism of microRNA inhibition by a new type of duplex oligonucleotide. The RNA society of Japan 18th annual meeting (The 21st annual meeting of the RNA society) 2016.06.29 Kyoto

149. Hiroshi Doi, Shigeru Koyano, Misako Kunii, Shunta Hashiguchi, Hitaru Kishida, Kenichi Tanaka, Masaaki Shiina, Kazuhiro Ogata, Fumiko Hirashima, Yukichi Inoue, Nozomu Sato, Kokoro Ozaki, Kiyobumi Ohta, Takanori Yokota, Hidehiro Mizusawa, Jun Mitsui, Shoji Tsuji, Naomichi Matsumoto, Kinya Ishikawa, Fumiaki Tanaka. The clinical and pathological features of autosomal-dominant SCA with CACNA1G mutation. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.21 Kobe

150. Keisuke Abe, Mio Tajiri, Daishi Yui, Hiroki Sasaguri, Takuya Ohkubo, Takanori Yokota. A C-terminal fragment of TDP-43 in exosomes mediates propagation of ALS pathology. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.20 Kobe

151. Masahiko Ichijo, Satoru Ishibashi, Kazunori Miki, Eri Iwasawa, Kyohei Fujita, Hiroaki Yokote, Takeshi Amino, Tomoyuki Kamata, Takanori Yokota. Significance of development and reversion of collaterals in outcome after intravenous thrombolysis. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.20 Kobe

152. Toshiro Kanazawa, Yurie Nose, Yutaro Asami, Jin Nonami, Masahide Iijima, Hiroaki Tanaka, Takanori Yokota. Clinical features of patients with motor fluctuations before intravenous thrombolysis. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.20 Kobe

153. Kazumasa Soga, Kinya Ishikawa, Tokuro Huruya, Hidehiro Mizusawa, Takanori Yokota. A clinical and neuropathological study on homozygous mutations with spinocerebellar ataxia type 6. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.20 Kobe

154. Yoichiro Nishida, Winkler Ethan, Sagare Abhay, De Vivo Darryl, Zlokovic Berislav. GLUT1 reductions at the BBB exacerbate Alzheimer disease vasculo-neuronal dysfunction. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.19 Kobe

155. Ogata H, Yamasaki R, Oka N, Kuwahara M, Suzuki H, Kusunoki S, Yagi Y, Yokota T, Matsushita T, Kira J-I. Useful laboratory markers for predicting anti-NF155 antibody status among CIDP patients. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.19 Kobe

156. Kazutaka Nishina, Kotaro Yoshioka, Tomoko Nishina, Hiroya Kuwahara, Tetsuya Nagata, Takanori Yokota. Novel oligonucleotide based on DNA/RNA heteroduplex structures. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.19 Kobe

157. Kotaro Yoshioka, Taiki Kunieda, Kie Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. A new type of double–stranded structure improved potency of antisense oligonucleotide for FAP. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.19 Kobe

158. Eri Iwasawa, Satoru Ishibashi, Masahiko Ichijo, Fu Ying Li, Takanori Yokota. Upregulation and distribution of sphingosine-1-phosphate receptor 1 in acute ischemic stroke. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.19 Kobe

159. Nozomu Sato, Kinya Ishikawa, Hidehiro Mizusawa, Takanori Yokota. Variations in the mutation for spinocerebellar ataxia type 31 require cautious genetic testing. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.19 Kobe

160. Jindong Song, Tetsuya Nagata, Wenying Piao, Kazutaka Nishina, Takuya Okubo, Keisuke Abe, Masato Hasegawa, Takanori Yokota. Inhibition of alpha-synuclein fibril assembly by antisense oligonucleotide in mice. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.18 Kobe

161. Fuying Li, Satoru Ishibashi, Kotaro Yoshioka, Takehiko Wada, Masahiko Ichijo, Eri Iwasawa, Jindong Song, Yongquan Zhang, Takanori Yokota. Heteroduplex oligonucleotide reduced gene expression in focal ischemic brain in mice. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.18 Kobe

162. Nobuo Sanjo, Hidehiro Mizusawa, Takanori Yokota. Various neurological manifestations of lymphoma. 57th Annual Meeting of the Japanese Society of Neurology 2016.05.18 Kobe

163. Takanori Yokota. DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. Oligonucleotide Therapeutics & Delivery 2016.04.04 Boston

164. Takanori Yokota. DNA/RNA heteroduplex oligonucleotide as a novel concept of therapeutic oligonucleotide. 8th AsiaTIDES Oligonucleotide and Peptide Therapeutics 2016.02.25 Kyoto

165. Song J, Shimoura T, Kuwahara H, Yoshida-Tanaka K, Nishina K, Nagata T, Yokota T. New platform technology to regulate the blood-brain barrier function in vivo. 第8回CBIR+ONSA共催若手インスパイアシンポジウム 2016.02.20 Tokyo

166. Asada K, Canestrari E, Fu X, Li Z, Makowski E, Wu YC, Mito JK, Kirsch DG, Baraban J, Paroo Z. Rescuing dicer Defects via Inhibition of an Anti-dicing Nuclease. The 2nd Annual Meeting of the Japan miRNA Society 2016.02.06 Nagoya

167. Inagaki M, Uematsu R, Araki Y, Sakamoto S, Ishibashi S, Kashida H, Asanuma H, Yokota T, Wada T. Synthesis and antisense activities of new type of chimeric PRNA-DNA derivatives containing phosphoramidate linkage in PRNA-DNA junction. 2015 International Chemical Congress of Pacific Basin Societies 2015.12.17 Honolulu, HI

168. Asai M, Uematsu R, Araki Y, Sakamoto S, Ishibashi S, Yokota T, Wada T. Tuning and optimization of on-off switching pH of PRNA for hypoxia specificity. 2015 International Chemical Congress of Pacific Basin Societies 2015.12.17 Honolulu, HI

169. Yokota T. 2´-DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. 2015 International Chemical Congress of Pacific Basin Societies 2015.12.15 Honolulu, HI

170. Kuwahara H, Shimoura T, Song J, Yoshida-Tanaka K, Nishina K, Nagata T, Yokota T. A new therapeutic oligonucleotide to regulate the blood-brain barrier in vivo. Barcelona BioMed Conference on “Blood Brain Barrier” 2015.11.02 Barcelona, Spain

171. Sanjo N, Tsukamoto T, Furukawa F, Higuma M, Hizume M, Nakamura Y, Satoh K, Kitamoto T, Yamada M, Yokota T, Mizusawa H. Human prion disease in Japan - a prospective surveillance from 1999. XXII World Congress of Neurology 2015.10.31 Santiago, Chile

172. Ishiguro T, Sato N, Fujikake N, Ueyama M, Yokota T, Mizusawa H, Wada K, Nagai Y, Ishikawa K. The SCA31-linked UGGAAexp repeat forms RNA foci and is translated into aggregating pentapeptide-repeat proteins in the SCA31 patient brain and Drosophila model. 10th Brain Research Conference 2015.10.15 Chicago, IL

173. Kuwahara H, Shimoura T, Song J, Yoshida-Tanaka K, Nishina K, Nagata T, Yokota T. A new therapeutic oligonucleotide to regulate the blood-brain barrier. 11th Annual Meeting of the Oligonucleotide Therapeutics Society 2015.10.14 Leiden, Netherlands

174. Kunieda T, Yoshioka K, Sujino Y, Yoshida-Tanaka K, Piao W, Kuwahara H, Nishina K, Nagata T, Yokota T. Enhancement of potency by gapmer type antisense oligonucleotides with Hetero-Chimera-Duplex-Oligonucleotide (HCDO). 11th Annual Meeting of the Oligonucleotide Therapeutics Society 2015.10.13 Leiden, Netherlands

175. Yoshioka K, Yoshida-Tanaka K, Piao W, Nishina T, Kuwahara H, Nishina K, Yokota T. Heteroduplex oligonucleotide (HDO): efficient drug delivery and processing mechanism. 11th Annual Meeting of the Oligonucleotide Therapeutics Society 2015.10.13 Leiden, Netherlands

176. Nagata T, Ihara K, Kaburagi H, Nishina K, Piao W, Yoshida-Tanaka K, Guo H, Kuwahara H, Yoshioka K, Yokota T. The effect of DNA/RNA heteroduplex oligonucleotides in multiple organ systems. 11th Annual Meeting of the Oligonucleotide Therapeutics Society 2015.10.12 Leiden, Netherlands

177. Furukawa F, Sanjo N, Kobayashi A, Hamaguchi T, Yamada M, Kitamoto T, Mizusawa H, Yokota T. Amyloid-β42 deposition in the brain of the Gerstmann-Sträussler-Scheinker disease with the P105L mutation. Asian Pacific Prion Symposium 2015 2015.09.04 Kanazawa, Japan

178. Tsukamoto T, Sanjo N, Hamaguchi T, Nakamura Y, Kitamoto T, Yamada M, Mizusawa H. CJD with M232R: Its clinic-pathological features. Asian Pacific Prion Symposium 2015 2015.09.04 Kanazawa, Japan

179. Sanjo N, Hamaguchi T, Tsukamoto T, Nakamura Y, Kitamoto T, Yamada M, Yokota T, Mizusawa H. Surveillance of prion disease in Japan. Asian Pacific Prion Symposium 2015 2015.09.04 Kanazawa, Japan

180. Ishiguro T, Fujikake N, Sato N, Ueyama M, Yokota T, Wada K, Mizusawa H, Nagai Y, Ishikawa K. Expanded UGGAA repeat RNA associated with SCA31 causes progressive neurodegeneration in Drosophila. The 38th Annual Meeting of the Japan Neuroscience Society, 2015.07.29 Kobe, Japan

181. Higuma M, Sanjo N, Mitoma H, Yokota T. Relationship between attention and gait cycle in the patients with Alzheimer's disease. Alzheimer's Association International Conference 2015 2015.07.18 Washington, DC

182. Furukawa F, Sanjo N, Higuma M, Kitamoto T, Hizume M, Nakamura Y, Tsukamoto T, Murayama S, Koshi K, Matsukawa T, Tsuji S, Goto J, Yamada M, Mizusawa H, Yokota T. Clinical features in Gerstmann-Straussler-Scheinker syndrome with P105L mutation. Prion2015 2015.05.26 CO

183. Hiroya Kuwahara, Takanori Yokota. Development of BBB-targeting nucleic acid medicine. The 37th Annual Meeting of the Japan Neuroscience Society 2014.09.13 Yokohama

184. Takanori Yokota. Oligonucleotide Gene Therapy for ALS. The 37th Annual Meeting of the Japan Neuroscience Society 2014.09.12 Yokohama

185. Keisuke Abe, Taku Namatame, Mio Tajiri, Daishi Yui, Takuya Ohkubo, Takanori Yokota. Selective uptake of C-terminal fragments of TDP-43 into exosome. The 37th Annual Meeting of Japan Neuroscience Society 2014.09.12 Yokohama,Japan

186. Takuya Ohkubo, Akira Machida, Kaoru Mogushi, Hidenori Matsuo, Atsushi Tsunoda, Taketoshi Maehara, Yuichi Noto, Toshio Shimizu, Satoshi Kuwabara, Takashi Kanda, Nobuyoshi Kosaka, Takahiro Ochiya, Takanori Yokota. Profiling of miRNAs in cerebrospinal fluid form patients with multifocal motor neuropathy and amyotrophic lateral sclerosis. The 37th Annual Meeting of the Japan Neuroscience Society 2014.09.11 Yokohama

187. Sekiguchi T, Kanouchi T, Shibuya K, Noto YI, Yagi Y, Inaba A, Abe K, Misawa S, Orimo S, Kobayashi T, Kamata T, Nakagawa M, Kuwabara S, Mizusawa H, Yokota T. Spreading of amyotrophic lateral sclerosis lesions -multifocal hits & local propagation?. 30th international congress of clinical neurophysiology of the IFCN 2014.03.21 Berlin