Personnel Information

写真a

WATANABE Mamoru


Job title

Distinguished Professor

Graduating School 【 display / non-display

  • Keio University, Faculty of Medicine, 1979, Graduated

Graduate School 【 display / non-display

  • Keio University, Graduate School, Division of Medicine, Doctor's Course, 1984, Completed

Degree 【 display / non-display

  • Medical doctor, Keio University

Campus Career 【 display / non-display

  • 2000.04
    -
    2019.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Gastroenterology and Hepatology, Professor
  • 2017.04
    -
    2017.09
    Tokyo Medical and Dental University, Board Member, Executive Director
  • 2017.10
    -
    2021.03
    Tokyo Medical and Dental University, Board Member, Executive Director
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University, TMDU Advanced Research Institute (TMDU-ARIS), , Distinguished Professor
  • 2021.04
    -
    2022.06
    Tokyo Medical and Dental University, TMDU Advanced Research Institute (TMDU-ARIS), , Distinguished Professor
  • 2022.07
    -
    Now
    Tokyo Medical and Dental University, TMDU Advanced Research Institute (TMDU-ARIS), , Inflammatory Bowel Disease Laboratory, Distinguished Professor

▼display all

External Career 【 display / non-display

  • 2021.04
    -
    Now
    Kiel University, Honorary doctor

Academic Society Affiliations 【 display / non-display

  • The Japanese Society for Gastroenterology

  • The Japanese Society of Internal Medicine

  • The Japanese Society for Mucosal Immunology

  • The Japan Gastroenterological Endoscopy Society

  • American Gastroenterological Association

Academic Activity 【 display / non-display

  • The Japanese Society for Gastroenterology Councilor
  • The Japanese Society for Mucosal Immunology Councilor
  • American Gastroenterological Association Fellow

Research Areas 【 display / non-display

  • Gastroenterology

 

Published Papers & Misc 【 display / non-display

  1. Stefan Schreiber, Gerhard Rogler, Mamoru Watanabe, Séverine Vermeire, Christian Maaser, Silvio Danese, Margaux Faes, Paul Van Hoek, Jeremy Hsieh, Ulrik Moerch, Yan Zhou, Angela de Haas, Christine Rudolph, Alessandra Oortwijn, Edward V Loftus. Integrated safety analysis of filgotinib for ulcerative colitis: Results from SELECTION and SELECTIONLTE. Aliment Pharmacol Ther. 2023.09; online (online): online. ( PubMed, DOI )

  2. Katsuyoshi Matsuoka, Hajime Yamazaki, Masakazu Nagahori, Taku Kobayashi, Teppei Omori, Yohei Mikami, Toshimitsu Fujii, Shinichiro Shinzaki, Masayuki Saruta, Minoru Matsuura, Takayuki Yamamoto, Satoshi Motoya, Toshifumi Hibi, Mamoru Watanabe, Jovelle Fernandez, Shunichi Fukuhara, Tadakazu Hisamatsu. Association of ulcerative colitis symptom severity and proctocolectomy with multidimensional patient-reported outcomes: a cross-sectional study. J Gastroenterol. 2023.08; 58 (8): 751-765. ( PubMed, DOI )

  3. Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi, Sakura Kirino, Masami Inoue, Yui Hiraguri, Sayaka Nagata, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Yasuhiro Nemoto, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Shiro Yui. Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment. J Gastroenterol. 2023.04; 58 (4): 379-393. ( PubMed, DOI )

  4. Daiki Yamada, Yudai Kojima, Akinori Hosoya, Masahiro Suzuki, Taro Watabe, Tadahiko Inoue, Naoya Tsugawa, Takehito Asakawa, Yuki Yonemoto, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Motoyuki Shimonaka, Keiji Kuba, Junji Ishida, Akiyoshi Fukamizu, Josef M Penninger, Mamoru Watanabe, Ryuichi Okamoto, Takashi Nagaishi. Apelin expression is downregulated in T cells in a murine model of chronic colitis. Biochem Biophys Res Commun. 2023.03; 647 72-79. ( PubMed, DOI )

  5. Johan Burisch, Mirabella Zhao, Selwyn Odes, Peter De Cruz, Severine Vermeire, Charles N Bernstein, Gilaad G Kaplan, Dana Duricova, Dan Greenberg, Hans O Melberg, Mamoru Watanabe, Hyeong Sik Ahn, Laura Targownik, Valérie E H Pittet, Vito Annese, K T Park, Konstantinos H Katsanos, Marte L Høivik, Zeljko Krznaric, María Chaparro, Edward V Loftus, Peter L Lakatos, Javier P Gisbert, Willem Bemelman, Bjorn Moum, Richard B Gearry, Michael D Kappelman, Ailsa Hart, Marieke J Pierik, Jane M Andrews, Siew C Ng, Renata D'Inca, Pia Munkholm. The cost of inflammatory bowel disease in high-income settings: a Lancet Gastroenterology & Hepatology Commission. Lancet Gastroenterol Hepatol. 2023.03; ( PubMed, DOI )

  6. Kento Takenaka, Ami Kawamoto, Yoshio Kitazume, Toshimitsu Fujii, Yumi Udagawa, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Transmural remission characterized by high biologic concentrations demonstrates better prognosis in Crohn's disease. J Crohns Colitis. 2022.12; ( PubMed, DOI )

  7. Kento Takenaka, Yoshio Kitazume, Ami Kawamoto, Toshimitsu Fujii, Yumi Udagawa, Ryosuke Wanatabe, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Hiroyuki Sato, Akihiro Hirakawa, Mamoru Watanabe, Ryuichi Okamoto. Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's Disease. Am J Gastroenterol. 2022.12; ( PubMed, DOI )

  8. Akiko Tamura, Go Ito, Hiroki Matsuda, Yoichi Nibe-Shirakihara, Yuichi Hiraoka, Sayuki Kitagawa, Yui Hiraguri, Sayaka Nagata, Emi Aonuma, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Mamoru Watanabe, Ryuichi Okamoto, Shigeru Oshima. Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis. Biochem Biophys Res Commun. 2022.11; 628 147-154. ( PubMed, DOI )

  9. Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano, Yasuhiro Nemoto, Mamoru Watanabe, Kiichiro Tsuchiya, Hiroshi Nishina, Ryuichi Okamoto, Shiro Yui. Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflamm Regen. 2022.11; 42 (1): 49. ( PubMed, DOI )

  10. Junichi Takahashi, Tomohiro Mizutani, Hady Yuki Sugihara, Sayaka Nagata, Shu Kato, Yui Hiraguri, Sayaka Takeoka, Mao Tsuchiya, Reiko Kuno, Sei Kakinuma, Mamoru Watanabe, Ryuichi Okamoto. Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids. Cell Rep Methods. 2022.11; 2 (11): 100337. ( PubMed, DOI )

  11. Geert D'Haens, Silvio Danese, Martin Davies, Mamoru Watanabe, Toshifumi Hibi. A phase II, Multicentre, Randomised, Double-Blind, Placebo-controlled Study to Evaluate Safety, Tolerability, and Efficacy of Amiselimod in Patients with Moderate to Severe Active Crohn's Disease. J Crohns Colitis. 2022.06; 16 (5): 746-756. ( PubMed, DOI )

  12. Julián Panés, Jean-Frederic Colombel, Geert R D'Haens, Stefan Schreiber, Remo Panaccione, Laurent Peyrin-Biroulet, Edward V Loftus, Silvio Danese, Satoshi Tanida, Yusuke Okuyama, Edouard Louis, Alessandro Armuzzi, Marc Ferrante, Harald Vogelsang, Toshifumi Hibi, Mamoru Watanabe, Jessica Lefebvre, Tricia Finney-Hayward, Yuri Sanchez Gonzalez, Thao T Doan, Nael M Mostafa, Kimitoshi Ikeda, Wangang Xie, Bidan Huang, Joel Petersson, Jasmina Kalabic, Anne M Robinson, William J Sandborn. Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results. Gastroenterology. 2022.06; 162 (7): 1891-1910. ( PubMed, DOI )

  13. Shuji Hibiya, Kazuo Ohtsuka, Kento Takenaka, Ami Kawamoto, Yusuke Matsuyama, Yumi Udagawa, Maiko Motobayashi, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Ryuichi Okamoto, Mamoru Watanabe. Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease. BMC Gastroenterol. 2022.05; 22 (1): 218. ( PubMed, DOI )

  14. Yoshio Kitazume, Kento Takenaka, Kazuo Ohtsuka, Yasuo Ozawa, Koichiro Kimura, Ryosuke Watanabe, Junichi Tsuchiya, Toshimitsu Fujii, Masakazu Nagahori, Mamoru Watanabe, Ukihide Tateishi. Motility Mapping Quantification Using the Classical Optical Flow Algorithm for Small Bowel Crohn's Disease: Comparison with Balloon-assisted Enteroscopy Findings. Magn Reson Med Sci. 2022.05; Online ahead of print. ( PubMed, DOI )

  15. Kento Takenaka, Ami Kawamoto, Ryuichi Okamoto, Mamoru Watanabe, Kazuo Ohtsuka. Artificial intelligence for endoscopy in inflammatory bowel disease. Intest Res. 2022.04; 20 (2): 165-170. ( PubMed, DOI )

  16. Ami Kawamoto, Kento Takenaka, Ryuichi Okamoto, Mamoru Watanabe, Kazuo Ohtsuka. Systematic review of artificial intelligence-based image diagnosis for inflammatory bowel disease. Dig Endosc. 2022.04; ( PubMed, DOI )

  17. Toshifumi Hibi, Satoshi Motoya, Tadakazu Hisamatsu, Fumihito Hirai, Kenji Watanabe, Katsuyoshi Matsuoka, Masayuki Saruta, Taku Kobayashi, Brian G Feagan, Chantal Tasset, Robin Besuyen, Chohee Yun, Gerald Crans, Jie Zhang, Akira Kondo, Mamoru Watanabe. Efficacy and safety of filgotinib as induction and maintenance therapy for Japanese patients with moderately to severely active ulcerative colitis: a post-hoc analysis of the phase 2b/3 SELECTION trial. Intest Res. 2022.03; Online ahead of print. ( PubMed, DOI )

  18. Katsuyoshi Matsuoka, Mamoru Watanabe, Toshihide Ohmori, Koichi Nakajima, Tetsuya Ishida, Yoh Ishiguro, Kazunari Kanke, Kiyonori Kobayashi, Fumihito Hirai, Kenji Watanabe, Hidehiro Mizusawa, Shuji Kishida, Yoshiharu Miura, Akira Ohta, Toshifumi Kajioka, Toshifumi Hibi, . AJM300 (carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis: a multicentre, randomised, double-blind, placebo-controlled, phase 3 study. Lancet Gastroenterol Hepatol. 2022.03; 7 (7): 648-657. ( PubMed, DOI )

  19. Satoshi Watanabe, Sakurako Kobayashi, Nobuhiko Ogasawara, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe, Kim B Jensen, Shiro Yui. Transplantation of intestinal organoids into a mouse model of colitis. Nat Protoc. 2022.02; 17 (3): 649-671. ( PubMed, DOI )

  20. Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima. Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice. Biochem Biophys Res Commun. 2022.02; 592 74-80. ( PubMed, DOI )

  21. Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe. Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study. Lancet Gastroenterol Hepatol. 2022.01; 7 (3): 230-237. ( PubMed, DOI )

  22. Makoto Naganuma, Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Toshiyuki Matsui, Yasuo Suzuki, Lyann Ursos, Shigeru Sakamoto, Mitsuhiro Shikamura, Tetsuharu Hori, Jovelle Fernandez, Mamoru Watanabe, Toshifumi Hibi, Takanori Kanai. Potential benefits of immunomodulator use with vedolizumab for maintenance of remission in ulcerative colitis. J Gastroenterol Hepatol. 2022.01; 37 (1): 81-88. ( PubMed, DOI )

  23. Katsuyoshi Ando, Mikihiro Fujiya, Kenji Watanabe, Sakiko Hiraoka, Hisashi Shiga, Shinji Tanaka, Hideki Iijima, Tsunekazu Mizushima, Taku Kobayashi, Masakazu Nagahori, Hiroki Ikeuchi, Shingo Kato, Takehiro Torisu, Kiyonori Kobayashi, Masaaki Higashiyama, Toshiro Fukui, Takashi Kagaya, Motohiro Esaki, Shunichi Yanai, Daiki Abukawa, Makoto Naganuma, Satoshi Motoya, Masayuki Saruta, Shigeki Bamba, Makoto Sasaki, Kazuhiko Uchiyama, Katsuyuki Fukuda, Hideo Suzuki, Hiroshi Nakase, Toshiaki Shimizu, Masahiro Iizuka, Mamoru Watanabe, Yasuo Suzuki, Tadakazu Hisamatsu. A nationwide survey concerning the mortality and risk of progressing severity due to arterial and venous thromboembolism in inflammatory bowel disease in Japan. J Gastroenterol. 2021.12; 56 (12): 1062-1079. ( PubMed, DOI )

  24. Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus. BMC Gastroenterol. 2021.12; 21 (1): 494. ( PubMed, DOI )

  25. Ai Minamidate, Michio Onizawa, Chikako Saito, Rie Hikichi, Tomoaki Mochimaru, Mai Murakami, Chiharu Sakuma, Takehito Asakawa, Yuichi Hiraoka, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe. A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production. Biochem Biophys Rep. 2021.09; 27 101065. ( PubMed, DOI )

  26. Shintaro Sagami, Kiyohiro Nishikawa, Fumika Yamada, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi. Post-marketing analysis for biosimilar CT-P13 in inflammatory bowel disease compared with external data of originator infliximab in Japan. J Gastroenterol Hepatol. 2021.08; 36 (8): 2091-2100. ( PubMed, DOI )

  27. Takehito Asakawa, Michio Onizawa, Chikako Saito, Rie Hikichi, Daiki Yamada, Ai Minamidate, Tomoaki Mochimaru, Shun-Ichiro Asahara, Yoshiaki Kido, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe. Oral administration of D-serine prevents the onset and progression of colitis in mice. J Gastroenterol. 2021.08; 56 (8): 732-745. ( PubMed, DOI )

  28. Yusuke Yasutomi, Asako Chiba, Keiichi Haga, Goh Murayama, Ayako Makiyama, Taiga Kuga, Mamoru Watanabe, Ryuichi Okamoto, Akihito Nagahara, Takashi Nagaishi, Sachiko Miyake. Activated Mucosal-associated Invariant T Cells Have a Pathogenic Role in a Murine Model of Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol. 2021.08; Online ahead of print. ( PubMed, DOI )

  29. Kento Takenaka, Ami Kawamoto, Shuji Hibiya, Kohei Suzuki, Toshimitsu Fujii, Maiko Motobayashi, Hiromichi Shimizu, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Mamoru Watanabe, Kazuo Ohtsuka. Higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn's disease. Aliment Pharmacol Ther. 2021.07; Online ahead of print.. ( PubMed, DOI )

  30. Sho Watanabe, Shuji Hibiya, Nobuhiro Katsukura, Sayuki Kitagawa, Ayako Sato, Ryuichi Okamoto, Mamoru Watanabe, Kiichiro Tsuchiya. Influence of chronic inflammation on the malignant phenotypes and the plasticity of colorectal cancer cells. Biochem Biophys Rep. 2021.07; 26 101031. ( PubMed, DOI )

  31. Takeo Yoshihara, Shinichiro Shinzaki, Takahiro Amano, Hideki Iijima, Tetsuo Takehara, Nagamu Inoue, Motoi Uchino, Motohiro Esaki, Taku Kobayashi, Masayuki Saruta, Ken Sugimoto, Shiro Nakamura, Keisuke Hata, Fumihito Hirai, Sakiko Hiraoka, Toshimitsu Fujii, Minoru Matsuura, Katsuyoshi Matsuoka, Kenji Watanabe, Hiroshi Nakase, Mamoru Watanabe. Concomitant use of an immunomodulator with ustekinumab as an induction therapy for Crohn's disease: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2021.07; 36 (7): 1744-1753. ( PubMed, DOI )

  32. A Kawamoto, K Takenaka, S Hibiya, K Ohtsuka, R Okamoto, M Watanabe. Serum leucine-rich -2 glycoprotein; a novel biomarker for small bowel mucosal activity in Crohn’s Disease. Clin Gastroenterol Hepatol. 2021.06; Online ahead of print.. ( PubMed, DOI )

  33. Brian G Feagan, Silvio Danese, Edward V Loftus, Séverine Vermeire, Stefan Schreiber, Timothy Ritter, Ronald Fogel, Rajiv Mehta, Sandeep Nijhawan, Radosław Kempiński, Rafał Filip, Ihor Hospodarskyy, Ursula Seidler, Frank Seibold, Ian L P Beales, Hyo Jong Kim, John McNally, Chohee Yun, Sally Zhao, Xiaopeng Liu, Chia-Hsiang Hsueh, Chantal Tasset, Robin Besuyen, Mamoru Watanabe, William J Sandborn, Gerhard Rogler, Toshifumi Hibi, Laurent Peyrin-Biroulet. Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): a phase 2b/3 double-blind, randomised, placebo-controlled trial. Lancet. 2021.06; 397 (10292): 2372-2384. ( PubMed, DOI )

  34. Shinichiro Shinzaki, Katsuyoshi Matsuoka, Hiroki Tanaka, Fuminao Takeshima, Shingo Kato, Takehiro Torisu, Yuki Ohta, Kenji Watanabe, Shiro Nakamura, Naoki Yoshimura, Taku Kobayashi, Akiko Shiotani, Fumihito Hirai, Sakiko Hiraoka, Mamoru Watanabe, Minoru Matsuura, Shohei Nishimoto, Shinta Mizuno, Hideki Iijima, Tetsuo Takehara, Tetsuji Naka, Takanori Kanai, Takayuki Matsumoto. Leucine-rich alpha-2 glycoprotein is a potential biomarker to monitor disease activity in inflammatory bowel disease receiving adalimumab: PLANET study. J Gastroenterol. 2021.06; 56 (6): 560-569. ( PubMed, DOI )

  35. Sho Watanabe, Shuji Hibiya, Nobuhiro Katsukura, Sayuki Kitagawa, Ayako Sato, Ryuichi Okamoto, Mamoru Watanabe, Kiichiro Tsuchiya. Importance of telomere shortening in the pathogenesis of ulcerative colitis: A new treatment from the aspect of telomeres in intestinal epithelial cells. J Crohns Colitis. 2021.06; 16 (1): 109-121. ( PubMed, DOI )

  36. Hiroshi Nakase, Motoi Uchino, Shinichiro Shinzaki, Minoru Matsuura, Katsuyoshi Matsuoka, Taku Kobayashi, Masayuki Saruta, Fumihito Hirai, Keisuke Hata, Sakiko Hiraoka, Motohiro Esaki, Ken Sugimoto, Toshimitsu Fuji, Kenji Watanabe, Shiro Nakamura, Nagamu Inoue, Toshiyuki Itoh, Makoto Naganuma, Tadakazu Hisamatsu, Mamoru Watanabe, Hiroto Miwa, Nobuyuki Enomoto, Tooru Shimosegawa, Kazuhiko Koike. Evidence-based clinical practice guidelines for inflammatory bowel disease 2020. J Gastroenterol. 2021.06; 56 (6): 489-526. ( PubMed, DOI )

  37. Takashi Nagaishi, Taro Watabe, Kunihiko Kotake, Toshihiko Kumazawa, Tomomi Aida, Kohichi Tanaka, Ryuichi Ono, Fumitoshi Ishino, Takako Usami, Takamasa Miura, Satomi Hirakata, Hiroko Kawasaki, Naoya Tsugawa, Daiki Yamada, Kazuhiro Hirayama, Soichiro Yoshikawa, Hajime Karasuyama, Ryuichi Okamoto, Mamoru Watanabe, Richard S Blumberg, Takahiro Adachi. Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum. Gut. 2021.05; Online ahead of print. ( PubMed, DOI )

  38. Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Shiori Oshima, Ryuichi Okamoto, Mamoru Watanabe. Deep Neural Network Accurately Predicts Prognosis of Ulcerative Colitis Using Endoscopic Images. Gastroenterology. 2021.05; 160 (6): 2175-2177.e3. ( PubMed, DOI )

  39. Taku Kobayashi, Satoshi Motoya, Shiro Nakamura, Takayuki Yamamoto, Masakazu Nagahori, Shinji Tanaka, Tadakazu Hisamatsu, Fumihito Hirai, Hiroshi Nakase, Kenji Watanabe, Takayuki Matsumoto, Masanori Tanaka, Takayuki Abe, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi, . Discontinuation of infliximab in patients with ulcerative colitis in remission (HAYABUSA): a multicentre, open-label, randomised controlled trial. Lancet Gastroenterol Hepatol. 2021.04; 6 (6): 429-437. ( PubMed, DOI )

  40. Motoi Uchino, Hiroki Ikeuchi, Keisuke Hata, Tomohiro Minagawa, Yuki Horio, Ryuichi Kuwahara, Shiro Nakamura, Kenji Watanabe, Masayuki Saruta, Toshimitsu Fujii, Taku Kobayashi, Ken Sugimoto, Fumihito Hirai, Motohiro Esaki, Sakiko Hiraoka, Katsuyoshi Matsuoka, Shinichiro Shinzaki, Minoru Matsuura, Nagamu Inoue, Hiroshi Nakase, Mamoru Watanabe. Does anti-tumor necrosis factor alpha prevent the recurrence of Crohn's disease? Systematic review and meta-analysis. J Gastroenterol Hepatol. 2021.04; 36 (4): 864-872.

  41. Shu Kato, Hiromichi Shimizu, Shohei Tomii, Hitoshi Uchida, Ami Kawamoto, Shuji Hibiya, Maiko Motobayashi, Kento Takenaka, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mariko Negi, Takumi Akashi, Takatoshi Matsuyama, Yusuke Kinugasa, Mamoru Watanabe. Substantial Epstein-Barr virus reactivation in a case of severe refractory ulcerative colitis: a possible role in exacerbation. Clin J Gastroenterol. 2021.04; 14 (2): 584-588. ( PubMed, DOI )

  42. Reiko Kuno, Go Ito, Ami Kawamoto, Yui Hiraguri, Hady Yuki Sugihara, Sayaka Takeoka, Sayaka Nagata, Junichi Takahashi, Mao Tsuchiya, Sho Anzai, Tomohiro Mizutani, Hiromichi Shimizu, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Mamoru Watanabe, Ryuichi Okamoto. Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients. Biochem Biophys Rep. 2021.03; 25 100906. ( PubMed, DOI )

  43. Miyuki Kaneshiro, Kento Takenaka, Kohei Suzuki, Toshimitsu Fujii, Shuji Hibiya, Ami Kawamoto, Maiko Motobayashi, Hiromichi Shimizu, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe. Pancolonic endoscopic and histologic evaluation for relapse prediction in patients with ulcerative colitis in clinical remission. Aliment Pharmacol Ther. 2021.03; 53 (8): 900-907. ( PubMed, DOI )

  44. Nobuhiro Katsukura, Sho Watanabe, Tomoaki Shirasaki, Shuji Hibiya, Yoshihito Kano, Keiichi Akahoshi, Minoru Tanabe, Susumu Kirimura, Takumi Akashi, Masanobu Kitagawa, Ryuichi Okamoto, Mamoru Watanabe, Kiichiro Tsuchiya. Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm. Cancer Sci. 2021.02; 112 (2): 932-944. ( PubMed, DOI )

  45. Sho Watanabe, Ryu Nishimura, Tomoaki Shirasaki, Nobuhiro Katsukura, Shuji Hibiya, Susumu Kirimura, Mariko Negi, Ryuichi Okamoto, Yuka Matsumoto, Tetsuya Nakamura, Mamoru Watanabe, Kiichiro Tsuchiya. Schlafen 11 is a novel target for mucosal regeneration in Ulcerative Colitis. J Crohns Colitis. 2021.02; Online ahead of print.. ( PubMed, DOI )

  46. Emi Aonuma, Akiko Tamura, Hiroki Matsuda, Takehito Asakawa, Yuriko Sakamaki, Kana Otsubo, Yoichi Nibe, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Tetsuya Nakamura, Motohiro Uo, Mamoru Watanabe, Ryuichi Okamoto, Shigeru Oshima. Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62. Biochem Biophys Res Commun. 2021.01; 542 17-23. ( PubMed, DOI )

  47. Mao Tsuchiya, Go Ito, Minami Hama, Sayaka Nagata, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Sho Anzai, Junichi Takahashi, Reiko Kuno, Sayaka Takeoka, Yui Hiraguri, Hady Yuki Sugihara, Tomohiro Mizutani, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Mamoru Watanabe, Ryuichi Okamoto. Functional analysis of isoflavones using patient-derived human colonic organoids. Biochem Biophys Res Commun. 2021.01; 542 40-47. ( PubMed, DOI )

  48. Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S Blumberg, Ryuichi Okamoto, Takashi Nagaishi. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation. Biochem Biophys Res Commun. 2021.01; 535 99-105. ( PubMed, DOI )

  49. Shuji Hibiya, Yusuke Matsuyama, Toshimitsu Fujii, Chiaki Maeyashiki, Eiko Saito, Kimiko Ito, Hiromichi Shimizu, Ami Kawamoto, Maiko Motobayashi, Kento Takenaka, Masakazu Nagahori, Masayuki Kurosaki, Tsunehito Yauchi, Kazuo Ohtsuka, Takeo Fujiwara, Ryuichi Okamoto, Mamoru Watanabe. 5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis. Aliment Pharmacol Ther. 2021.01; 53 (1): 103-113. ( PubMed, DOI )

  50. Masakazu Nagahori, Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Takanori Kanai, Toshiyuki Matsui, Yasuo Suzuki, Philippe Pinton, Lyann Ursos, Shigeru Sakamoto, Mitsuhiro Shikamura, Tetsuharu Hori, Jovelle Fernandez, Toshifumi Hibi, Mamoru Watanabe. Week 2 Symptomatic Response with Vedolizumab as a Predictive Factor in Japanese Anti-TNFα-Naive Patients with Ulcerative Colitis: A post hoc Analysis of a Randomized, Placebo-Controlled Phase 3 Trial. Digestion. 2021.01; 15 1-11. ( PubMed, DOI )

  51. Ryo Morikawa, Yasuhiro Nemoto, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Kengo Nozaki, Tomohiro Mizutani, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto. Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. Cell Mol Gastroenterol Hepatol. 2021; 11 (5): 1483-1503. ( PubMed, DOI )

  52. Tadakazu Hisamatsu, Yasuo Suzuki, Mariko Kobayashi, Takashi Hagiwara, Takeshi Kawaberi, Haruhiko Ogata, Toshiyuki Matsui, Mamoru Watanabe, Toshifumi Hibi. Long-term safety and effectiveness of adalimumab in Japanese patients with Crohn's disease: 3-year results from a real-world study. Intest Res. 2020.11; Online ahead of print. ( PubMed, DOI )

  53. Yoshio Kitazume, Junichi Tsuchiya, Kento Takenaka, Kazuo Ohtsuka, Koichiro Kimura, Ryosuke Watanabe, Tomoyuki Fujioka, Toshimitsu Fujii, Mamoru Watanabe, Ukihide Tateisi. High b-value computed diffusion-weighted imaging for differentiating bowel inflammation in Crohn's disease. Eur J Radiol. 2020.10; 133 109362. ( PubMed, DOI )

  54. Motoi Uchino, Hiroki Ikeuchi, Keisuke Hata, Tomohiro Minagawa, Yuki Horio, Ryuichi Kuwahara, Shiro Nakamura, Kenji Watanabe, Masayuki Saruta, Toshimitsu Fujii, Taku Kobayashi, Ken Sugimoto, Fumihito Hirai, Motohiro Esaki, Sakiko Hiraoka, Katsuyoshi Matsuoka, Shinichiro Shinzaki, Minoru Matsuura, Nagamu Inoue, Hiroshi Nakase, Mamoru Watanabe. Intestinal cancer in patients with Crohn's disease: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2020.08; Online ahead of print.. ( PubMed, DOI )

  55. Mina Nakagawa, Nobutoshi Nawa, Eiko Takeichi, Taro Shimizu, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Takeo Fujiwara, Mamoru Watanabe, Yujiro Tanaka, Yasuhiro Asahina, . Mac-2 binding protein glycosylation isomer as a novel predictive biomarker for patient survival after hepatitis C virus eradication by DAAs. J. Gastroenterol. 2020.08; ( PubMed, DOI )

  56. Taku Kobayashi, Hiroaki Ito, Toshifumi Ashida, Tadashi Yokoyama, Masakazu Nagahori, Tomoki Inaba, Mitsuhiro Shikamura, Takayoshi Yamaguchi, Tetsuharu Hori, Philippe Pinton, Mamoru Watanabe, Toshifumi Hibi. Efficacy and safety of a new vedolizumab subcutaneous formulation in Japanese patients with moderately to severely active ulcerative colitis. Intest Res. 2020.08; Online ahead of print. ( PubMed, DOI )

  57. Zhihua Ran, Kaichun Wu, Katsuyoshi Matsuoka, Yoon Tae Jeen, Shu Chen Wei, Vineet Ahuja, Minhu Chen, Pin-Jin Hu, Akira Andoh, Hyo Jong Kim, Suk-Kyun Yang, Mamoru Watanabe, Siew Chien Ng, Toshifumi Hibi, Ida Normiha Hilmi, Yasuo Suzuki, Dong Soo Han, Wai Keung Leung, Jose Sollano, Choon Jin Ooi, Jiaming Qian. Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology practice recommendations for medical management and monitoring of inflammatory bowel disease in Asia. J Gastroenterol Hepatol. 2020.07; 36 637-645. ( PubMed, DOI )

  58. Keisuke Hata, Soichiro Ishihara, Yoichi Ajioka, Keiichi Mitsuyama, Kenji Watanabe, Hiroyuki Hanai, Reiko Kunisaki, Hiroshi Nakase, Keiji Matsuda, Ryuichi Iwakiri, Nobuyuki Hida, Shinji Tanaka, Yoshiaki Takeuchi, Masaru Shinozaki, Noriyuki Ogata, Kentaro Moriichi, Fumihito Hirai, Kenichi Sugihara, Tadakazu Hisamatsu, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi. Long-term follow-up of targeted biopsy yield (LOFTY Study) in ulcerative colitis surveillance colonoscopy. J Clin Med. 2020.07; 9 (7): 2286. ( PubMed, DOI )

  59. Hideki Iijima, Taku Kobayashi, Mitsuo Nagasaka, Shinichiro Shinzaki, Kazuya Kitamura, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi. Management of primary nonresponders and partial responders to tumor necrosis factor-α inhibitor induction therapy among patients with Crohn's disease. Inflamm Intest Dis. 2020.06; 5 (2): 78-83. ( PubMed, DOI )

  60. Masaaki Higashiyama, Shunsuke Komoto, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi, Soichiro Miura, Ryota Hokari. Relation of geriatric nutritional risk index with clinical risks in elderly-onset ulcerative colitis. J Gastroenterol Hepatol. 2020.06; Online ahead of print. ( PubMed, DOI )

  61. Hiromichi Shimizu, Toshimitsu Fujii, Shuji Hibiya, Maiko Motobayashi, Kohei Suzuki, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis. Intest Res. 2020.06; Online ahead of print.. ( PubMed, DOI )

  62. Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Mariko Negi, Kohei Suzuki, Hiromichi Shimizu, Shiori Oshima, Shintaro Akiyama, Maiko Motobayashi, Masakazu Nagahori, Eiko Saito, Katsuyoshi Matsuoka, Mamoru Watanabe. Development and Validation of a Deep Neural Network for Accurate Evaluation of Endoscopic Images From Patients With Ulcerative Colitis. Gastroenterology. 2020.06; 158 (8): 2150-2157. ( PubMed, DOI )

  63. Kento Takenaka, Yoshio Kitazume, Toshimitsu Fujii, Kiichiro Tsuchiya, Mamoru Watanabe, Kazuo Ohtsuka. Objective evaluation for treat to target in Crohn's disease. J Gastroenterol. 2020.06; 55 (6): 579-587. ( PubMed, DOI )

  64. Sho Anzai, Ami Kawamoto, Sayaka Nagata, Junichi Takahashi, Mao Kawai, Reiko Kuno, Sakurako Kobayashi, Satoshi Watanabe, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Shigeru Oshima, Mamoru Watanabe, Ryuichi Okamoto. TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells. Biochem. Biophys. Res. Commun.. 2020.04; 524 (3): 533-541. ( PubMed, DOI )

  65. Yuria Takei, Yasuhiro Nemoto, Ryo Morikawa, Shohei Tanaka, Shigeru Oshima, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. T cells show amoeboid shape and frequent morphological change in vitro, and localize to small intestinal intraepithelial region in vivo. Biochem. Biophys. Res. Commun.. 2020.03; 523 (2): 328-335. ( PubMed, DOI )

  66. Ryuichi Okamoto, Hiromichi Shimizu, Kohei Suzuki, Ami Kawamoto, Junichi Takahashi, Mao Kawai, Sayaka Nagata, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Mamoru Watanabe. Organoid-based regenerative medicine for inflammatory bowel disease. Regen Ther. 2020.03; 13 1-6. ( PubMed, DOI )

  67. Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Takanori Kanai, Toshiyuki Matsui, Yasuo Suzuki, Mitsuhiro Shikamura, Kenkichi Sugiura, Kazunori Oda, Tetsuharu Hori, Takahiro Araki, Mamoru Watanabe, Toshifumi Hibi. Effects of vedolizumab in Japanese patients with Crohn's disease: a prospective, multicenter, randomized, placebo-controlled Phase 3 trial with exploratory analyses. J Gastroenterol. 2020.03; 55 (3): 291-306. ( PubMed, DOI )

  68. Shohei Tanaka, Yasuhiro Nemoto, Yuria Takei, Ryo Morikawa, Shigeru Oshima, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Susanne Stutte, Mamoru Watanabe. High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage. Biochem. Biophys. Res. Commun.. 2020.02; 522 (4): 971-977. ( PubMed, DOI )

  69. Ayako Sato, Sei Kakinuma, Masato Miyoshi, Akihide Kamiya, Tomoyuki Tsunoda, Shun Kaneko, Jun Tsuchiya, Taro Shimizu, Eiko Takeichi, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe. Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts. Hepatol Commun. 2020.02; 4 (2): 235-254. ( PubMed, DOI )

  70. Kana Otsubo, Chiaki Maeyashiki, Yoichi Nibe, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Masanori Kobayashi, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Satoru Torii, Eisuke Itakura, Mamoru Watanabe, Shigeru Oshima. Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells. FEBS Lett. 2020.02; 594 (10): 1586-1595. ( PubMed, DOI )

  71. Toshifumi Hibi, Makoto Naganuma, Eisei Oda, Yoji Yamada, Yoshitomo Chujoh, Ryoichi Yoshihara, Mamoru Watanabe. Predictive factors for achievement of mucosal healing by budesonide 2-mg foam in ulcerative colitis: a pooled analysis of data from two clinical trials. Intest Res. 2020.01; 18 (1): 56-68. ( PubMed, DOI )

  72. Masayuki Saruta, Dong Il Park, Young-Ho Kim, Suk-Kyun Yang, Byung-Ik Jang, Jae Hee Cheon, Jong Pil Im, Takanori Kanai, Tatsuro Katsuno, Yoh Ishiguro, Makoto Nagaoka, Naoki Isogawa, Yinhua Li, Anindita Banerjee, Alaa Ahmad, Mina Hassan-Zahraee, Robert Clare, Kenneth J Gorelick, Fabio Cataldi, Mamoru Watanabe, Toshifumi Hibi. Anti-MAdCAM-1 antibody (PF-00547659) for active refractory Crohn's disease in Japanese and Korean patients: the OPERA study. Intest Res. 2020.01; 18 (1): 45-55. ( PubMed, DOI )

  73. Sayuri Nitta, Kazuaki Takahashi, Fukiko Kawai-Kitahata, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Miyako Murakawa, Yasuhiro Istui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Mamoru Watanabe, Yasuhiro Asahina. Time course alterations of virus sequences and immunoglobulin titers in a chronic hepatitis E patient Hepatology Research. 2020; 50 (4): 524-531.

  74. Shun Kaneko, Masayuki Kurosaki, Nobuharu Tamaki, Jun Itakura, Tsuguru Hayashi, Sakura Kirino, Leona Osawa, Keiya Watakabe, Mao Okada, Wan Wang, Takao Shimizu, Mayu Higuchi, Kenta Takaura, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Takahashi, Mamoru Watanabe, Namiki Izumi. Tenofovir alafenamide for hepatitis B virus infection including switching therapy from tenofovir disoproxil fumarate. J Gastroenterol Hepatol. 2019.11; 34 (11): 2004-2010. ( PubMed, DOI )

  75. Tadakazu Hisamatsu, Shingo Kato, Reiko Kunisaki, Minoru Matsuura, Masakazu Nagahori, Satoshi Motoya, Motohiro Esaki, Norimasa Fukata, Satoko Inoue, Takeshi Sugaya, Hirotake Sakuraba, Fumihito Hirai, Kenji Watanabe, Takanori Kanai, Makoto Naganuma, Hiroshi Nakase, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi, Masanori Nojima, Takayuki Matsumoto. Withdrawal of thiopurines in Crohn's disease treated with scheduled adalimumab maintenance: a prospective randomised clinical trial (DIAMOND2). J Gastroenterol. 2019.10; 54 (10): 860-870. ( PubMed, DOI )

  76. Shintaro Akiyama, Katsuyoshi Matsuoka, Kyoko Fukuda, Shunsuke Hamada, Mikiko Shimizu, Kosaku Nanki, Shinta Mizuno, Hiroki Kiyohara, Mari Arai, Shinya Sugimoto, Yasushi Iwao, Haruhiko Ogata, Tadakazu Hisamatsu, Makoto Naganuma, Maiko Motobayashi, Kohei Suzuki, Kento Takenaka, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mayumi Mochizuki, Mamoru Watanabe, Masayuki Hashiguchi, Takanori Kanai. Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine. J Gastroenterol Hepatol. 2019.10; 34 (10): 1751-1757. ( PubMed, DOI )

  77. Tomoo Nakagawa, Taku Kobayashi, Kiyohiro Nishikawa, Fumika Yamada, Satoshi Asai, Yukinori Sameshima, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi. Infliximab biosimilar CT-P13 is interchangeable with its originator for patients with inflammatory bowel disease in real world practice. Intest Res. 2019.10; 17 (4): 504-515. ( PubMed, DOI )

  78. Yasuo Suzuki, Mamoru Watanabe, Toshiyuki Matsui, Satoshi Motoya, Tadakazu Hisamatsu, Hirotoshi Yuasa, Junichi Tabira, Naoki Isogawa, Shinichi Tsuchiwata, Shoko Arai, Toshifumi Hibi. Tofacitinib as induction and maintenance therapy in Japanese patients with active ulcerative colitis. Inflamm Intest Dis. 2019.10; 4 (4): 131-143. ( PubMed, DOI )

  79. Takashi Nagaishi, Daiki Yamada, Kohei Suzuki, Ryosuke Fukuyo, Eiko Saito, Masayoshi Fukuda, Taro Watabe, Naoya Tsugawa, Kengo Takeuchi, Kouhei Yamamoto, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe. Indolent T cell lymphoproliferative disorder with villous atrophy in small intestine diagnosed by single-balloon enteroscopy. Clin J Gastroenterol. 2019.10; 12 (5): 434-440. ( PubMed, DOI )

  80. Tadakazu Hisamatsu, Takayuki Matsumoto, Kenji Watanabe, Hiroshi Nakase, Satoshi Motoya, Naoki Yoshimura, Tetsuya Ishida, Shingo Kato, Tomoo Nakagawa, Motohiro Esaki, Masakazu Nagahori, Toshiyuki Matsui, Yuji Naito, Takanori Kanai, Yasuo Suzuki, Masanori Nojima, Mamoru Watanabe, Toshifumi Hibi, . Concerns and side effects of azathioprine during adalimumab induction and maintenance therapy for Japanese patients with Crohn's disease: a sub-analysis of a prospective randomized clinical trial (DIAMOND study). J Crohns Colitis. 2019.09; 13 (9): 1097-1104. ( PubMed, DOI )

  81. Sayaka Tsuda, Azusa Sameshima, Michikazu Sekine, Haruna Kawaguchi, Daisuke Fujita, Shintaro Makino, Akio Morinobu, Yohko Murakawa, Kiyoshi Matsui, Takao Sugiyama, Mamoru Watanabe, Yasuo Suzuki, Masakazu Nagahori, Atsuko Murashima, Tatsuya Atsumi, Kenji Oku, Nobuaki Mitsuda, Syuji Takei, Takako Miyamae, Naoto Takahashi, Ken Nakajima, Shigeru Saito, . Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan: Multi-center retrospective descriptive study. Mod Rheumatol. 2019.09; 1-10. ( PubMed, DOI )

  82. Hajime Yamazaki, Katsuyoshi Matsuoka, Jovelle Fernandez, Toshifumi Hibi, Mamoru Watanabe, Tadakazu Hisamatsu, Shunichi Fukuhara. Ulcerative colitis outcomes research in Japan: protocol for an observational prospective cohort study of YOURS (YOu and Ulcerative colitis: Registry and Social network). BMJ Open. 2019.09; 9 (9): e030134. ( PubMed, DOI )

  83. Kento Takenaka, Toshimitsu Fujii, Kohei Suzuki, Hiromichi Shimizu, Maiko Motobayashi, Shuji Hibiya, Eiko Saito, Masakazu Nagahori, Mamoru Watanabe, Kazuo Ohtsuka. Small Bowel Healing Detected by Endoscopy in Patients With Crohn's Disease After Treatment With Antibodies Against Tumor Necrosis Factor. Clin. Gastroenterol. Hepatol.. 2019.08; (18): 1545-1552. ( PubMed, DOI )

  84. Tomoyuki Tsunoda, Sei Kakinuma, Masato Miyoshi, Akihide Kamiya, Shun Kaneko, Ayako Sato, Jun Tsuchiya, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Tsuyoshi Sogo, Haruki Komatsu, Ryutaro Mukouchi, Ayano Inui, Tomoo Fujisawa, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe. Loss of fibrocystin promotes interleukin-8-dependent proliferation and CTGF production of biliary epithelium. J Hepatol. 2019.07; 71 (1): 143-152. ( PubMed, DOI )

  85. Hiromichi Shimizu, Kohei Suzuki, Mamoru Watanabe, Ryuichi Okamoto. Stem cell-based therapy for inflammatory bowel disease. Intest Res. 2019.07; 17 (3): 311-316. ( PubMed, DOI )

  86. Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shun Kaneko, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Tomoyuki Tsunoda, Emi Inoue-Shinomiya, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Minoru Tanabe, Emiko Sugawara, Akira Takemoto, Hidenori Ojima, Michiie Sakamoto, Masaru Muraoka, Shinichi Takano, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe. Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma. Hepatol. Res.. 2019.07; 49 1466-1474. ( PubMed, DOI )

  87. Sei Kakinuma, Mamoru Watanabe. Analysis of the mechanism underlying liver diseases using human induced pluripotent stem cells. Immunol Med. 2019.06; 42 (2): 71-78. ( PubMed, DOI )

  88. Maiko Motobayashi, Katsuyoshi Matsuoka, Kento Takenaka, Toshimitsu Fujii, Masakazu Nagahori, Kazuo Ohtsuka, Fumihiko Iwamoto, Kiichiro Tsuchiya, Mariko Negi, Yoshinobu Eishi, Mamoru Watanabe. Predictors of mucosal healing during induction therapy in patients with acute moderate-to-severe ulcerative colitis. J Gastroenterol Hepatol. 2019.06; 34 (6): 1004-1010.

  89. Akira Doi, Hayato Hikita, Yugo Kai, Yuki Tahata, Yoshinobu Saito, Tasuku Nakabori, Ryoko Yamada, Takahiro Kodama, Ryotaro Sakamori, Asako Murayama, Sayuri Nitta, Yasuhiro Asahina, Hiroshi Suemizu, Tomohide Tatsumi, Takanobu Kato, Tetsuo Takehara. Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice. J Gastroenterol. 2019.05; 54 (5): 449-458. ( PubMed, DOI )

  90. Sayuri Nitta, Yasuhiro Asahina, Takanobu Kato, Jun Tsuchiya, Emi Inoue-Shinomiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Hayato Hikita, Tetsuo Takehara, Mamoru Watanabe. Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients. Sci Rep. 2019.04; 9 (1): 5722. ( PubMed, DOI )

  91. Sho Watanabe, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Nobuhiro Katsukura, Shuji Hibiya, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Mutation by CRISPR System Enhances the Malignant Potential of Colon Cancer. Mol. Cancer Res.. 2019.04; ( PubMed, DOI )

  92. Atsushi Yoshida, Noriko Kamata, Akihiro Yamada, Yoko Yokoyama, Teppei Omori, Toshimitsu Fujii, Ryohei Hayashi, Tetsu Kinjo, Akira Matsui, Norimasa Fukata, Sakuma Takahashi, Ryosuke Sakemi, Noriyuki Ogata, Shinya Ashizuka, Shigeki Bamba, Makoto Ooi, Shuji Kanmura, Katsuya Endo, Takuya Yoshino, Hiroki Tanaka, Toshio Morizane, Shinichiro Shinzaki, Taku Kobayashi. Pneumonia in patients with inflammatory bowel disease. Inflamm Intest Dis. 2019.04; 3 (4): 167-172. ( PubMed, DOI )

  93. Kaho Yamasaki, Kento Takenaka, Kazuo Ohtsuka. Laterally Spreading Tumor-like Early Cancer in Ileum. Intern Med. 2019.03; 58 (6): 885-886. ( PubMed, DOI )

  94. Motohiro Esaki, Takayuki Matsumoto, Naoki Ohmiya, Ema Washio, Toshifumi Morishita, Kei Sakamoto, Hiroo Abe, Shojiro Yamamoto, Tetsu Kinjo, Kazutomo Togashi, Kenji Watanabe, Fumihito Hirai, Masanao Nakamura, Sadaharu Nouda, Shinya Ashizuka, Teppei Omori, Shuji Kochi, Shunichi Yanai, Yuta Fuyuno, Atsushi Hirano, Junji Umeno, Takanari Kitazono, Fukunori Kinjo, Mamoru Watanabe, Toshiyuki Matsui, Yasuo Suzuki. Capsule endoscopy findings for the diagnosis of Crohn's disease: a nationwide case-control study. J Gastroenterol. 2019.03; 54 (3): 249-260. ( PubMed, DOI )

  95. Masato Miyoshi, Sei Kakinuma, Akihide Kamiya, Tomoyuki Tsunoda, Jun Tsuchiya, Ayako Sato, Shun Kaneko, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe. LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. Sci Rep. 2019.02; 9 (1): 2072. ( PubMed, DOI )

  96. Satoshi Motoya, Kenji Watanabe, Haruhiko Ogata, Takanori Kanai, Toshiyuki Matsui, Yasuo Suzuki, Mitsuhiro Shikamura, Kenkichi Sugiura, Kazunori Oda, Tetsuharu Hori, Takahiro Araki, Mamoru Watanabe, Toshifumi Hibi. Vedolizumab in Japanese patients with ulcerative colitis: A Phase 3, randomized, double-blind, placebo-controlled study. PLoS ONE. 2019.02; 14 (2): e0212989. ( PubMed, DOI )

  97. Seishin Azuma, Yasuhiro Asahina, Sei Kakinuma, Keiko Azuma, Masato Miyoshi, Emi Inoue, Tomoyuki Tsunoda, Ayako Sato, Shun Kaneko, Hiroko Nagata, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Makoto Tomita, Mina Nakagawa, Mamoru Watanabe. Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease. [Epub ahead of print] Dig Dis. 2019.01; 37 247-254. ( PubMed, DOI )

  98. Ryu Nishimura, Tomoaki Shirasaki, Kiichiro Tsuchiya, Yoshihide Miyake, Yusuke Watanabe, Shuji Hibiya, Sho Watanabe, Tetsuya Nakamura, Mamoru Watanabe. Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids. J. Gastroenterol.. 2019.01; 54 608-620. ( PubMed, DOI )

  99. Makoto Naganuma, Fumihito Hirai, Kiyonori Kobayashi, Kenji Watanabe, Ken Takeuchi, Nobuo Aoyama, Hiroshi Nozawa, Satoshi Motoya, Toshihide Ohmori, Akio Harada, Yushi Nagai, Takayuki Abe, Yoji Yamada, Katsutoshi Inagaki, Naoki Shimizu, Takanori Kanai, Mamoru Watanabe. Middle-term prognosis in patients with ulcerative colitis who achieved clinical and endoscopic remission by budesonide rectal foam. PLoS One. 2019; 14 (8): e0220413. ( PubMed, DOI )

  100. Maiko Motobayashi, Katsuyoshi Matsuoka, Kento Takenaka, Toshimitsu Fujii, Masakazu Nagahori, Kazuo Ohtsuka, Fumihiko Iwamoto, Kiichiro Tsuchiya, Mariko Negi, Yoshinobu Eishi, Mamoru Watanabe. Predictors of mucosal healing during induction therapy in patients with acute moderate-to-severe ulcerative colitis.[Epub ahead of print] J. Gastroenterol. Hepatol. 2018.12; ( PubMed, DOI )

  101. Yuki Tanisaka, Shomei Ryozawa, Masafumi Mizuide, Masanori Kobayashi, Akashi Fujita, Kazuhiro Minami, Tsutomu Kobatake, Kumiko Omiya, Hirotoshi Iwano, Ryuichiro Araki. Usefulness of the "newly designed" short-type single-balloon enteroscope for ERCP in patients with Roux-en-Y gastrectomy: a pilot study. Endosc Int Open. 2018.12; 6 (12): E1417-E1422. ( PubMed, DOI )

  102. Ami Kawamoto, Sayaka Nagata, Sho Anzai, Junichi Takahashi, Mao Kawai, Minami Hama, Daichi Nogawa, Kohei Yamamoto, Reiko Kuno, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Shiro Yui, Shigeru Ohshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Masanobu Kitagawa, Ryuichi Okamoto, Mamoru Watanabe. Ubiquitin D is up-regulated by synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients. J Crohns Colitis. 2018.11; ( PubMed, DOI )

  103. Shigeru Oshima, Mamoru Watanabe. Genetic and environmental factors drive personalized medicine for Crohn's disease. J. Clin. Invest.. 2018.11; 128 (11): 4758-4760. ( PubMed, DOI )

  104. Mayu Higuchi, Nobuharu Tamaki, Masayuki Kurosaki, Keiya Watakabe, Leona Osawa, Wan Wang, Mao Okada, Takao Shimizu, Kenta Takaura, Hitomi Takada, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Namiki Izumi. Prediction of Hepatocellular Carcinoma After Sustained Virological Responses Using Magnetic Resonance Elastography. Clin. Gastroenterol. Hepatol.. 2018.11; ( PubMed, DOI )

  105. Tadakazu Hisamatsu, Reiko Kunisaki, Shiro Nakamura, Tomoyuki Tsujikawa, Fumihito Hirai, Hiroshi Nakase, Kenji Watanabe, Kaoru Yokoyama, Masakazu Nagahori, Takanori Kanai, Makoto Naganuma, Hirofumi Michimae, Akira Andoh, Akihiro Yamada, Tadashi Yokoyama, Noriko Kamata, Shinji Tanaka, Yasuo Suzuki, Toshifumi Hibi, Mamoru Watanabe, . Effect of elemental diet combined with infliximab dose escalation in patients with Crohn's disease with loss of response to infliximab: CERISIER trial. Intest Res. 2018.07; 16 (3): 494-498. ( PubMed, DOI )

  106. Meng-Tzu Weng, Sang Hyoung Park, Katsuyoshi Matsuoka, Chien-Chih Tung, Jae Yong Lee, Chin-Hao Chang, Suk-Kyun Yang, Mamoru Watanabe, Jau-Min Wong, Shu-Chen Wei. Incidence and Risk Factor Analysis of Thromboembolic Events in East Asian Patients With Inflammatory Bowel Disease, a Multinational Collaborative Study. Inflamm. Bowel Dis. 2018.07; 24 (8): 1791-1800. ( PubMed, DOI )

  107. Satoshi Motoya, Mamoru Watanabe, Kori Wallace, Andreas Lazar, Yasuko Nishimura, Morio Ozawa, Roopal Thakkar, Anne M Robinson, Ravi Shankar Prasad Singh, Nael M Mostafa, Yasuo Suzuki, Toshifumi Hibi. Efficacy and Safety of Dose Escalation to Adalimumab 80 mg Every Other Week in Japanese Patients with Crohn's Disease Who Lost Response to Maintenance Therapy. Inflamm Intest Dis. 2018.07; 2 (4): 228-235. ( PubMed, DOI )

  108. Kouhei Fukushima, Akira Sugita, Kitaro Futami, Ken-Ichi Takahashi, Satoshi Motoya, Hideaki Kimura, Shusaku Yoshikawa, Yoshitaka Kinouchi, Hideki Iijima, Katsuya Endo, Toshihumi Hibi, Mamoru Watanabe, Iwao Sasaki, Yasuo Suzuki, . Postoperative therapy with infliximab for Crohn's disease: a 2-year prospective randomized multicenter study in Japan. Surg. Today. 2018.06; 48 (6): 584-590. ( PubMed, DOI )

  109. Fumihiko Iwamoto, Katsuyoshi Matsuoka, Maiko Motobayashi, Kento Takenaka, Toru Kuno, Keisuke Tanaka, Yuya Tsukui, Shoji Kobayashi, Takashi Yoshida, Toshimitsu Fujii, Eiko Saito, Tatsuya Yamaguchi, Masakazu Nagahori, Tadashi Sato, Kazuo Ohtsuka, Nobuyuki Enomoto, Mamoru Watanabe. Prediction of disease activity of Crohn's disease through fecal calprotectin evaluated by balloon-assisted endoscopy. J. Gastroenterol. Hepatol. 2018.06; ( PubMed, DOI )

  110. Naoki Hosoe, Masaru Nakano, Ken Takeuchi, Yutaka Endo, Katsuyoshi Matsuoka, Takayuki Abe, Teppei Omori, Mari Hayashida, Taku Kobayashi, Atsushi Yoshida, Shinta Mizuno, Nakazato Yoshihiro, Makoto Naganuma, Takanori Kanai, Mamoru Watanabe, Fumiaki Ueno, Yasuo Suzuki, Toshifumi Hibi, Haruhiko Ogata. Establishment of a Novel Scoring System for Colon Capsule Endoscopy to Assess the Severity of Ulcerative Colitis-Capsule Scoring of Ulcerative Colitis. Inflamm. Bowel Dis. 2018.05; ( PubMed, DOI )

  111. Yoshiki Wada, Masayoshi Fukuda, Kazuo Ohtsuka, Mamoru Watanabe, Yumiko Fukuma, Yoko Wada, Masahiro Wada. Efficacy of Endocuff-assisted colonoscopy in the detection of colorectal polyps. Endosc Int Open. 2018.04; 6 (4): E425-E431. ( PubMed, DOI )

  112. Kenji Watanabe, Takayuki Matsumoto, Tadakazu Hisamatsu, Hiroshi Nakase, Satoshi Motoya, Naoki Yoshimura, Tetsuya Ishida, Shingo Kato, Tomoo Nakagawa, Motohiro Esaki, Masakazu Nagahori, Toshiyuki Matsui, Yuji Naito, Takanori Kanai, Yasuo Suzuki, Masanori Nojima, Mamoru Watanabe, Toshifumi Hibi, . Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn's Disease. Clin. Gastroenterol. Hepatol. 2018.04; 16 (4): 542-549.e1. ( PubMed, DOI )

  113. Makoto Naganuma, Nobuo Aoyama, Tomohiro Tada, Kiyonori Kobayashi, Fumihito Hirai, Kenji Watanabe, Mamoru Watanabe, Toshifumi Hibi. Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study. J. Gastroenterol. 2018.04; 53 (4): 494-506. ( PubMed, DOI )

  114. Makoto Naganuma, Nobuo Aoyama, Tomohiro Tada, Kiyonori Kobayashi, Fumihito Hirai, Kenji Watanabe, Mamoru Watanabe, Toshifumi Hibi. Correction to: Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study. J. Gastroenterol. 2018.04; 53 (4): 579-581. ( PubMed, DOI )

  115. Shunsuke Komoto, Masaaki Higashiyama, Chikako Watanabe, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi, Toru Takebayashi, Keiko Asakura, Yuji Nishiwaki, Soichiro Miura, Ryota Hokari. Clinical differences between elderly-onset ulcerative colitis and non-elderly-onset ulcerative colitis: A nationwide survey data in Japan. J. Gastroenterol. Hepatol. 2018.04; 33 1839-1843. ( PubMed, DOI )

  116. Taku Kobayashi, Tadakazu Hisamatsu, Yasuo Suzuki, Haruhiko Ogata, Akira Andoh, Toshimitsu Araki, Ryota Hokari, Hideki Iijima, Hiroki Ikeuchi, Yoh Ishiguro, Shingo Kato, Reiko Kunisaki, Takayuki Matsumoto, Satoshi Motoya, Masakazu Nagahori, Shiro Nakamura, Hiroshi Nakase, Tomoyuki Tsujikawa, Makoto Sasaki, Kaoru Yokoyama, Naoki Yoshimura, Kenji Watanabe, Miiko Katafuchi, Mamoru Watanabe, Toshifumi Hibi. Predicting outcomes to optimize disease management in inflammatory bowel disease in Japan: their differences and similarities to Western countries. Intest Res. 2018.04; 16 (2): 168-177. ( PubMed, DOI )

  117. Satoshi Motoya, Mamoru Watanabe, Hyo Jong Kim, Young Ho Kim, Dong Soo Han, Hirotoshi Yuasa, Junichi Tabira, Naoki Isogawa, Shoko Arai, Isao Kawaguchi, Toshifumi Hibi. Tofacitinib induction and maintenance therapy in East Asian patients with active ulcerative colitis: subgroup analyses from three phase 3 multinational studies. Intest Res. 2018.04; 16 (2): 233-245. ( PubMed, DOI )

  118. Emma Calabrese, Torsten Kucharzik, Christian Maaser, Giovanni Maconi, Deike Strobel, Stephanie R Wilson, Francesca Zorzi, Kerri L Novak, David H Bruining, Marietta Iacucci, Mamoru Watanabe, Elisabetta Lolli, Carlo Chiaramonte, Stephen B Hanauer, Remo Panaccione, Francesco Pallone, Subrata Ghosh, Giovanni Monteleone. Real-time Interobserver Agreement in Bowel Ultrasonography for Diagnostic Assessment in Patients With Crohn's Disease: An International Multicenter Study. Inflamm. Bowel Dis. 2018.04; 24 (9): 2001-2006. ( PubMed, DOI )

  119. Shintaro Akiyama, Masakazu Nagahori, Shinya Oooka, Mariko Negi, Takashi Ito, Kento Takenaka, Kazuo Ohtsuka, Mamoru Watanabe. Small intestinal obstruction due to the metastasis of intrahepatic cholangiocarcinoma: A case report. Medicine (Baltimore). 2018.03; 97 (12): e0190. ( PubMed, DOI )

  120. Makoto Naganuma, Shinya Sugimoto, Keiichi Mitsuyama, Taku Kobayashi, Naoki Yoshimura, Hidehisa Ohi, Shinji Tanaka, Akira Andoh, Naoki Ohmiya, Keiichiro Saigusa, Takayuki Yamamoto, Yuichi Morohoshi, Hitoshi Ichikawa, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Kenji Watanabe, Shinta Mizuno, Wataru Suda, Masahira Hattori, Shinji Fukuda, Akiyoshi Hirayama, Takayuki Abe, Mamoru Watanabe, Toshifumi Hibi, Yasuo Suzuki, Takanori Kanai, . Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis. Gastroenterology. 2018.03; 154 (4): 935-947. ( PubMed, DOI )

  121. Fumihito Hirai, Akira Andoh, Fumiaki Ueno, Kenji Watanabe, Naoki Ohmiya, Hiroshi Nakase, Shingo Kato, Motohiro Esaki, Yutaka Endo, Hironori Yamamoto, Toshiyuki Matsui, Mitsuo Iida, Toshifumi Hibi, Mamoru Watanabe, Yasuo Suzuki, Takayuki Matsumoto. Efficacy of endoscopic balloon dilation for small bowel strictures in patients with Crohn's disease: A nationwide, multi-center, open-label, prospective cohort study. J Crohns Colitis. 2018.03; 12 (4): 394-401. ( PubMed, DOI )

  122. Hiroko Nagata, Mina Nakagawa, Yasuhiro Asahina. M2BP as Indicators of the risk of HCC after SVR". J. Hepatol. 2018.03; 68 (3): 607-608. ( PubMed, DOI )

  123. Vishnu Mohanan, Toru Nakata, A Nicole Desch, Chloé Lévesque, Angela Boroughs, Gaelen Guzman, Zhifang Cao, Elizabeth Creasey, Junmei Yao, Gabrielle Boucher, Guy Charron, Atul K Bhan, Monica Schenone, Steven A Carr, Hans-Christian Reinecker, Mark J Daly, John D Rioux, Kara G Lassen, Ramnik J Xavier. C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science. 2018.03; 359 (6380): 1161-1166. ( PubMed, DOI )

  124. Katsuyoshi Matsuoka, Taku Kobayashi, Fumiaki Ueno, Toshiyuki Matsui, Fumihito Hirai, Nagamu Inoue, Jun Kato, Kenji Kobayashi, Kiyonori Kobayashi, Kazutaka Koganei, Reiko Kunisaki, Satoshi Motoya, Masakazu Nagahori, Hiroshi Nakase, Fumio Omata, Masayuki Saruta, Toshiaki Watanabe, Toshiaki Tanaka, Takanori Kanai, Yoshinori Noguchi, Ken-Ichi Takahashi, Kenji Watanabe, Toshifumi Hibi, Yasuo Suzuki, Mamoru Watanabe, Kentaro Sugano, Tooru Shimosegawa. Evidence-based clinical practice guidelines for inflammatory bowel disease. J. Gastroenterol.. 2018.03; 53 (3): 305-353. ( PubMed, DOI )

  125. Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe. B cell activation in the cecal patches during the development of an experimental colitis model. Biochem. Biophys. Res. Commun. 2018.02; 496 (2): 367-373. ( PubMed, DOI )

  126. Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Katsuyoshi Matsuoka, Masakazu Nagahori, Toshimitsu Fujii, Eiko Saito, Maiko Kimura, Tomoyuki Fujioka, Mamoru Watanabe. Utility of Magnetic Resonance Enterography For Small Bowel Endoscopic Healing in Patients With Crohn's Disease. Am. J. Gastroenterol. 2018.02; 113 (2): 283-294. ( PubMed, DOI )

  127. Kohei Suzuki, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Toru Nakata, Satoru Fujii, Fumiaki Ishibashi, Ami Kawamoto, Sho Anzai, Reiko Kuno, Konomi Kuwabara, Junichi Takahashi, Minami Hama, Sayaka Nagata, Yui Hiraguri, Kento Takenaka, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties.[Epub ahead of print] J. Gastroenterol. 2018.01; 53 1035-1047. ( PubMed, DOI )

  128. Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P Fordham, Stine L Hansen, Hjalte L Larsen, Jordi Guiu, Mariana R P Alves, Carsten F Rundsten, Jens V Johansen, Yuan Li, Chris D Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H Nielsen, Pawel J Schweiger, Stefano Piccolo, Kim B Jensen. YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration. Cell Stem Cell. 2018.01; 22 (1): 35-49.e7. ( PubMed, DOI )

  129. Fumiaki Ishibashi, Hiromichi Shimizu, Toru Nakata, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Sho Anzai, Reiko Kuno, Sayaka Nagata, Go Ito, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto. Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium. Stem Cell Reports. 2018.01; 10 (1): 27-42. ( PubMed, DOI )

  130. Dong Ii Park, Tadakazu Hisamatsu, Minhu Chen, Siew Chien Ng, Choon Jin Ooi, Shu Chen Wei, Rupa Banerjee, Ida Normiha Hilmi, Yoon Tae Jeen, Dong Soo Han, Hyo Jong Kim, Zhihua Ran, Kaichun Wu, Jiaming Qian, Pin-Jin Hu, Katsuyoshi Matsuoka, Akira Andoh, Yasuo Suzuki, Kentaro Sugano, Mamoru Watanabe, Toshifumi Hibi, Amarender S Puri, Suk-Kyun Yang. Asian Organization for Crohn's and Colitis and Asian Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 1: Risk assessment. J. Gastroenterol. Hepatol. 2018.01; 33 (1): 20-29. ( PubMed, DOI )

  131. Dong Il Park, Tadakazu Hisamatsu, Minhu Chen, Siew Chien Ng, Choon Jin Ooi, Shu Chen Wei, Rupa Banerjee, Ida Normiha Hilmi, Yoon Tae Jeen, Dong Soo Han, Hyo Jong Kim, Zhihua Ran, Kaichun Wu, Jiaming Qian, Pin-Jin Hu, Katsuyoshi Matsuoka, Akira Andoh, Yasuo Suzuki, Kentaro Sugano, Mamoru Watanabe, Toshifumi Hibi, Amarender S Puri, Suk-Kyun Yang. Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 2: Management. J. Gastroenterol. Hepatol. 2018.01; 33 (1): 30-36. ( PubMed, DOI )

  132. Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe. Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62. Autophagy. 2018.01; 24 347-358. ( PubMed, DOI )

  133. Retraction: Adult tissue stem cell therapy for gastrointestinal diseases by Mamoru Watanabe. J Gastroenterol Hepatol. 2018.01; 33 (1): 329. ( PubMed, DOI )

  134. Dong Il Park, Tadakazu Hisamatsu, Minhu Chen, Siew Chien Ng, Choon Jin Ooi, Shu Chen Wei, Rupa Banerjee, Ida Normiha Hilmi, Yoon Tae Jeen, Dong Soo Han, Hyo Jong Kim, Zhihua Ran, Kaichun Wu, Jiaming Qian, Pin-Jin Hu, Katsuyoshi Matsuoka, Akira Andoh, Yasuo Suzuki, Kentaro Sugano, Mamoru Watanabe, Toshifumi Hibi, Amarender S Puri, Suk-Kyun Yang. Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 2: management. Intest Res. 2018.01; 16 (1): 17-25. ( PubMed, DOI )

  135. Dong ll Park, Tadakazu Hisamatsu, Minhu Chen, Siew Chien Ng, Choon Jin Ooi, Shu Chen Wei, Rupa Banerjee, Ida Normiha Hilmi, Yoon Tae Jeen, Dong Soo Han, Hyo Jong Kim, Zhihua Ran, Kaichun Wu, Jiaming Qian, Pin-Jin Hu, Katsuyoshi Matsuoka, Akira Andoh, Yasuo Suzuki, Kentaro Sugano, Mamoru Watanabe, Toshifumi Hibi, Amarender S Puri, Suk-Kyun Yang. Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 1: risk assessment. Intest Res. 2018.01; 16 (1): 4-16. ( PubMed, DOI )

  136. H Nakase, S Motoya, T Matsumoto, K Watanabe, T Hisamatsu, N Yoshimura, T Ishida, S Kato, T Nakagawa, M Esaki, M Nagahori, T Matsui, Y Naito, T Kanai, Y Suzuki, M Nojima, M Watanabe, T Hibi. Significance of measurement of serum trough level and anti-drug antibody of adalimumab as personalised pharmacokinetics in patients with Crohn's disease: a subanalysis of the DIAMOND trial. Aliment. Pharmacol. Ther. 2017.11; 46 (9): 873-882. ( PubMed, DOI )

  137. Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K Naruse, Mamoru Watanabe, Akinori Kimura. MKL1 expressed in macrophages contributes to the development of murine colitis. Sci Rep. 2017.10; 7 (1): 13650. ( PubMed, DOI )

  138. Yuka Matsumoto, Wakana Mochizuki, Shintaro Akiyama, Taichi Matsumoto, Kengo Nozaki, Mamoru Watanabe, Tetsuya Nakamura. Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection. Biol Open. 2017.09; 6 (9): 1364-1374. ( PubMed, DOI )

  139. Fumio Goto, Sei Kakinuma, Masato Miyoshi, Tomoyuki Tsunoda, Shun Kaneko, Ayako Sato, Yu Asano, Satoshi Otani, Seishin Azuma, Hiroko Nagata, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Yasuhiro Asahina, Mamoru Watanabe. Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells. Hepatol. Res. 2017.08; 47 (9): 941-952. ( PubMed, DOI )

  140. Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Katsuyoshi Matsuoka, Toshimitsu Fujii, Masakazu Nagahori, Maiko Kimura, Tomoyuki Fujioka, Akihiro Araki, Mamoru Watanabe. Magnetic resonance evaluation for small bowel strictures in Crohn's disease: comparison with balloon enteroscopy. J. Gastroenterol. 2017.08; 52 (8): 879-888. ( PubMed, DOI )

  141. Masaru Shinozaki, Kiyonori Kobayashi, Reiko Kunisaki, Tadakazu Hisamatsu, Makoto Naganuma, Ken-Ichi Takahashi, Yasushi Iwao, Yasuo Suzuki, Mamoru Watanabe, Michio Itabashi, Akira Torii, Masakazu Takazoe, Akira Sugita. Surveillance for dysplasia in patients with ulcerative colitis: Discrepancy between guidelines and practice. Dig Endosc. 2017.07; 29 (5): 584-593. ( PubMed, DOI )

  142. Miyako Murakawa, Yasuhiro Asahina, Hiroko Nagata, Mina Nakagawa, Sei Kakinuma, Sayuri Nitta, Fukiko Kawai-Kitahata, Satoshi Otani, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Ayako Sato, Yasuhiro Itsui, Seishin Azuma, Toshihiko Nouchi, Yohei Furumoto, Tooru Asano, Yoshimichi Chuganji, Shuji Tohda, Mamoru Watanabe. ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin. Hepatol. Res. 2017.07; 29 (5): 584-593. ( PubMed, DOI )

  143. Miyako Murakawa, Yasuhiro Asahina, Fukiko Kawai-Kitahata, Mina Nakagawa, Sayuri Nitta, Satoshi Otani, Hiroko Nagata, Shun Kaneko, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Yasuhito Tanaka, Sayuki Iijima, Kaoru Tsuchiya, Namiki Izumi, Shuji Tohda, Mamoru Watanabe. Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. J. Med. Virol. 2017.07; 89 (7): 1241-1247. ( PubMed, DOI )

  144. Hiroko Nagata, Mina Nakagawa, Yasuhiro Asahina, Ayako Sato, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Shun Kaneko, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Toshihiko Nouchi, Hideki Sakai, Makoto Tomita, Mamoru Watanabe, . Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C. J. Hepatol. 2017.06; ( PubMed, DOI )

  145. Shuji Hibiya, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Nobukatsu Horita, Sho Watanabe, Tomoaki Shirasaki, Ryu Nishimura, Natsuko Kimura, Tatsunori Nishimura, Noriko Gotoh, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids. J Crohns Colitis. 2017.05; 11 (5): 621-630. ( PubMed, DOI )

  146. Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Nobukatsu Horita, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Satoshi Motoya, Yoshiaki Takeuchi, Reiko Kunisaki, Ken Fukunaga, Shiro Nakamura, Naoki Yoshimura, Masakazu Takazoe, Bunei Iizuka, Yasuo Suzuki, Masakazu Nagahori, Mamoru Watanabe. Caudal type homeobox 2 expression induced by leukocytapheresis might be associated with mucosal healing in ulcerative colitis J. Gastroenterol. Hepatol. 2017.05; 32 (5): 1032-1039. ( PubMed, DOI )

  147. Masakazu Nagahori, Shuji Kochi, Hiroyuki Hanai, Takayuki Yamamoto, Shiro Nakamura, Soji Omuro, Mamoru Watanabe, Toshifumi Hibi, . Real life results in using 5-ASA for maintaining mild to moderate UC patients in Japan, a multi-center study, OPTIMUM Study. BMC Gastroenterol. 2017.04; 17 (1): 47. ( PubMed, DOI )

  148. Norie Yamada,Ryuichi Sugiyama,Sayuri Nitta,Asako Murayama,Minoru Kobayashi,Chiaki Okuse,Michihiro Suzuki,Kiyomi Yasuda,Hiroshi Yotsuyanagi,Kyoji Moriya,Kazuhiko Koike,Takaji Wakita,and Takanobu Kato. Resistance mutations of hepatitis B virus in entecavir-refractory patients HEPATOLOGY COMMUNICATIONS. 2017.04; 1 (2): 110-121.

  149. Susumu Tazuma, Michiaki Unno, Yoshinori Igarashi, Kazuo Inui, Kazuhisa Uchiyama, Masahiro Kai, Toshio Tsuyuguchi, Hiroyuki Maguchi, Toshiyuki Mori, Koji Yamaguchi, Shomei Ryozawa, Yuji Nimura, Naotaka Fujita, Keiichi Kubota, Junichi Shoda, Masami Tabata, Tetsuya Mine, Kentaro Sugano, Mamoru Watanabe, Tooru Shimosegawa. Evidence-based clinical practice guidelines for cholelithiasis 2016. J. Gastroenterol. 2017.03; 52 (3): 276-300. ( PubMed, DOI )

  150. Chiaki Maeyashiki, Shigeru Oshima, Kana Otsubo, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. Biochem. Biophys. Res. Commun. 2017.03; 484 (3): 636-641. ( PubMed, DOI )

  151. Kosuke Fujimoto, Makoto Kinoshita, Hiroo Tanaka, Daisuke Okuzaki, Yosuke Shimada, Hisako Kayama, Ryu Okumura, Yoki Furuta, Masashi Narazaki, Atsushi Tamura, Shigetsugu Hatakeyama, Masahito Ikawa, Kiichiro Tsuchiya, Mamoru Watanabe, Atsushi Kumanogoh, Sachiko Tsukita, Kiyoshi Takeda. Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Mucosal Immunol. 2017.03; 10 (2): 446-459. ( PubMed, DOI )

  152. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto. Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine. Data Brief. 2017.02; 10 551-556. ( PubMed, DOI )

  153. Erika Kuwahara, Yoshitaka Murakami, Takahiro Nakamura, Nagamu Inoue, Masakazu Nagahori, Toshiyuki Matsui, Mamoru Watanabe, Yasuo Suzuki, Yuji Nishiwaki. Factors associated with exacerbation of newly diagnosed mild ulcerative colitis based on a nationwide registry in Japan. J. Gastroenterol. 2017.02; 52 (2): 185-193. ( PubMed, DOI )

  154. Tetsuya Nakamura, Mamoru Watanabe. Intestinal stem cell transplantation. J. Gastroenterol. 2017.02; 52 (2): 151-157. ( PubMed, DOI )

  155. Shinichiro Shinzaki, Katsuyoshi Matsuoka, Hideki Iijima, Shinta Mizuno, Satoshi Serada, Minoru Fujimoto, Norimitsu Arai, Noriyuki Koyama, Eiichi Morii, Mamoru Watanabe, Toshifumi Hibi, Takanori Kanai, Tetsuo Takehara, Tetsuji Naka. Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis. J Crohns Colitis. 2017.01; 11 (1): 84-91. ( PubMed, DOI )

  156. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto. Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors. Biochem. Biophys. Res. Commun. 2017.01; 482 (4): 1296-1303. ( PubMed, DOI )

  157. Toshiaki Watanabe, Yoichi Ajioka, Keiichi Mitsuyama, Kenji Watanabe, Hiroyuki Hanai, Hiroshi Nakase, Reiko Kunisaki, Keiji Matsuda, Ryuichi Iwakiri, Nobuyuki Hida, Shinji Tanaka, Yoshiaki Takeuchi, Kazuo Ohtsuka, Kazunari Murakami, Kiyonori Kobayashi, Yasushi Iwao, Masakazu Nagahori, Bunei Iizuka, Keisuke Hata, Masahiro Igarashi, Ichiro Hirata, Shin-Ei Kudo, Takayuki Matsumoto, Fumiaki Ueno, Gen Watanabe, Masahiro Ikegami, Yoko Ito, Koji Oba, Eisuke Inoue, Naoki Tomotsugu, Toru Takebayashi, Kenichi Sugihara, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi. Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-Associated Colorectal Cancer. Gastroenterology. 2016.12; 151 (6): 1122-1130. ( PubMed, DOI )

  158. Hiroko Nagata, Mina Nakagawa, Yuki Nishimura-Sakurai, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Shun Kaneko, Fumio Goto, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Naoko Tojo, Shuji Tohda, Yasuhiro Asahina, Mamoru Watanabe. Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy. Hepatol Int. 2016.11; 10 (6): 956-964. ( PubMed, DOI )

  159. Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Tatsuro Murano, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Akihiro Araki, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe. PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells. Sci Rep. 2016.11; 6 36795. ( PubMed, DOI )

  160. Masanori Kobayashi, Shigeru Oshima, Chiaki Maeyashiki, Yoichi Nibe, Kana Otsubo, Yu Matsuzawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Sci Rep. 2016.11; 6 36780. ( PubMed, DOI )

  161. Toshiyuki Kojima, Kiichiro Tsuchiya, Shinji Ikemizu, Soichiro Yoshikawa, Yoshinori Yamanishi, Mamoru Watanabe, Hajime Karasuyama. Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R. Sci Rep. 2016.11; 6 36457. ( PubMed, DOI )

  162. Masato Miyoshi, Sei Kakinuma, Yoko Tanabe, Koji Ishii, Tian-Cheng Li, Takaji Wakita, Yukio Tsuura, Hideki Watanabe, Yasuhiro Asahina, Mamoru Watanabe, Takaaki Ikeda. Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy. Intern. Med. 2016.10; 55 (19): 2811-2817. ( PubMed, DOI )

  163. Sayuri Nitta, Yasuhiro Asahina, Mami Matsuda, Norie Yamada, Ryuichi Sugiyama, Takahiro Masaki, Ryosuke Suzuki, Nobuyuki Kato, Mamoru Watanabe, Takaji Wakita, Takanobu Kato. Effects of Resistance-Associated NS5A Mutations in Hepatitis C Virus on Viral Production and Susceptibility to Antiviral Reagents. Sci Rep. 2016.10; 6 34652. ( PubMed, DOI )

  164. Yoshihito Kano, Jonathan D Cook, Jeffrey E Lee, Michael Ohh. New structural and functional insight into the regulation of Ras. Semin. Cell Dev. Biol. 2016.10; 58 70-78. ( PubMed, DOI )

  165. Haruhiko Ogata, Mamoru Watanabe, Toshiyuki Matsui, Hidenori Hase, Motohiro Okayasu, Tsuyoshi Tsuchiya, Yasuhiko Shinmura, Toshifumi Hibi. Safety of Adalimumab and Predictors of Adverse Events in 1693 Japanese Patients with Crohn's Disease. J Crohns Colitis. 2016.09; 10 (9): 1033-1041. ( PubMed, DOI )

  166. Ryuichi Okamoto, Mariko Negi, Syohei Tomii, Yoshinobu Eishi, Mamoru Watanabe. Diagnosis and treatment of microscopic colitis. Clin J Gastroenterol. 2016.08; 9 (4): 169-174. ( PubMed, DOI )

  167. Katsuhiko Iwakiri, Yoshikazu Kinoshita, Yasuki Habu, Tadayuki Oshima, Noriaki Manabe, Yasuhiro Fujiwara, Akihito Nagahara, Osamu Kawamura, Ryuichi Iwakiri, Soji Ozawa, Kiyoshi Ashida, Shuichi Ohara, Hideyuki Kashiwagi, Kyoichi Adachi, Kazuhide Higuchi, Hiroto Miwa, Kazuma Fujimoto, Motoyasu Kusano, Yoshio Hoshihara, Tatsuyuki Kawano, Ken Haruma, Michio Hongo, Kentaro Sugano, Mamoru Watanabe, Tooru Shimosegawa. Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015. J. Gastroenterol. 2016.08; 51 (8): 751-767. ( PubMed, DOI )

  168. Naoki Hosoe, Kenji Watanabe, Takako Miyazaki, Masaaki Shimatani, Takahiro Wakamatsu, Kazuichi Okazaki, Motohiro Esaki, Takayuki Matsumoto, Takayuki Abe, Takanori Kanai, Kazuo Ohtsuka, Mamoru Watanabe, Keiichi Ikeda, Hisao Tajiri, Naoki Ohmiya, Masanao Nakamura, Hidemi Goto, Tomoyuki Tsujikawa, Haruhiko Ogata. Evaluation of performance of the Omni mode for detecting video capsule endoscopy images: A multicenter randomized controlled trial. Endosc Int Open. 2016.08; 4 (8): E878-E882. ( PubMed, DOI )

  169. Ryuichi Okamoto, Mamoru Watanabe. Investigating cell therapy for inflammatory bowel disease. Expert Opin Biol Ther. 2016.08; 16 (8): 1015-1023. ( PubMed, DOI )

  170. Taichi Matsumoto, Wakana Mochizuki, Yoichi Nibe, Shintaro Akiyama, Yuka Matsumoto, Kengo Nozaki, Masayoshi Fukuda, Ayumi Hayashi, Tomohiro Mizutani, Shigeru Oshima, Mamoru Watanabe, Tetsuya Nakamura. Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism. PLoS ONE. 2016.08; 11 (8): e0162049. ( PubMed, DOI )

  171. Hiroshi Fukui, Hidetsugu Saito, Yoshiyuki Ueno, Hirofumi Uto, Katsutoshi Obara, Isao Sakaida, Akitaka Shibuya, Masataka Seike, Sumiko Nagoshi, Makoto Segawa, Hirohito Tsubouchi, Hisataka Moriwaki, Akinobu Kato, Etsuko Hashimoto, Kojiro Michitaka, Toshikazu Murawaki, Kentaro Sugano, Mamoru Watanabe, Tooru Shimosegawa. Evidence-based clinical practice guidelines for liver cirrhosis 2015. J. Gastroenterol. 2016.07; 51 (7): 629-650. ( PubMed, DOI )

  172. Shun Kaneko, Sei Kakinuma, Yasuhiro Asahina, Akihide Kamiya, Masato Miyoshi, Tomoyuki Tsunoda, Sayuri Nitta, Yu Asano, Hiroko Nagata, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Hiromitsu Nakauchi, Hironori Nishitsuji, Saneyuki Ujino, Kunitada Shimotohno, Masashi Iwamoto, Koichi Watashi, Takaji Wakita, Mamoru Watanabe. Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus. Sci Rep. 2016.07; 6 29358. ( PubMed, DOI )

  173. Ryuichi Okamoto, Mamoru Watanabe. Functional relevance of intestinal epithelial cells in inflammatory bowel disease. Nihon Rinsho Meneki Gakkai Kaishi. 2016.06; 39 (6): 522-527. ( PubMed, DOI )

  174. Kara G Lassen, Craig I McKenzie, Muriel Mari, Tatsuro Murano, Jakob Begun, Leigh A Baxt, Gautam Goel, Eduardo J Villablanca, Szu-Yu Kuo, Hailiang Huang, Laurence Macia, Atul K Bhan, Marcel Batten, Mark J Daly, Fulvio Reggiori, Charles R Mackay, Ramnik J Xavier. Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Immunity. 2016.06; 44 (6): 1392-1405. ( PubMed, DOI )

  175. Emma Calabrese, Christian Maaser, Francesca Zorzi, Klaus Kannengiesser, Stephen B Hanauer, David H Bruining, Marietta Iacucci, Giovanni Maconi, Kerri L Novak, Remo Panaccione, Deike Strobel, Stephanie R Wilson, Mamoru Watanabe, Francesco Pallone, Subrata Ghosh. Bowel Ultrasonography in the Management of Crohn's Disease. A Review with Recommendations of an International Panel of Experts. Inflamm. Bowel Dis. 2016.05; 22 (5): 1168-1183. ( PubMed, DOI )

  176. Ryohei Hayashi, Kiichiro Tsuchiya, Keita Fukushima, Nobukatsu Horita, Shuji Hibiya, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Shinji Fukuda, Hiroshi Ohno, Ryuichi Okamoto, Tetsuya Nakamura, Shinji Tanaka, Kazuaki Chayama, Mamoru Watanabe. Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease. Inflamm. Bowel Dis. 2016.05; 22 (5): 1119-1128. ( PubMed, DOI )

  177. Kazuo Ohtsuka, Kento Takenaka, Yoshio Kitazume, Toshimitsu Fujii, Katsuyoshi Matsuoka, Maiko Kimura, Takashi Nagaishi, Mamoru Watanabe. Magnetic resonance enterography for the evaluation of the deep small intestine in Crohn's disease. Intest Res. 2016.04; 14 (2): 120-126. ( PubMed, DOI )

  178. Shunsuke Komoto, Satoshi Motoya, Yuji Nishiwaki, Toshiyuki Matsui, Reiko Kunisaki, Katsuyoshi Matsuoka, Naoki Yoshimura, Takashi Kagaya, Makoto Naganuma, Nobuyuki Hida, Mamoru Watanabe, Toshifumi Hibi, Yasuo Suzuki, Soichiro Miura, Ryota Hokari, . Pregnancy outcome in women with inflammatory bowel disease treated with anti-tumor necrosis factor and/or thiopurine therapy: a multicenter study from Japan Intest Res. 2016.04; 14 (2): 139-145. ( PubMed, DOI )

  179. Miki Taniguchi, Megumi Tasaka-Fujita, Mina Nakagawa, Takako Watanabe, Fukiko Kawai-Kitahata, Satoshi Otani, Fumio Goto, Hiroko Nagata, Shun Kaneko, Sayuri Nitta, Miyako Murakawa, Yuki Nishimura-Sakurai, Seishin Azuma, Yasuhiro Itsui, Kenichi Mori, Shintaro Yagi, Sei Kakinuma, Yasuhiro Asahina, Mamoru Watanabe. Evaluation of Interferon Resistance in Newly Established Genotype 1b Hepatitis C Virus Cell Culture System. J Clin Transl Hepatol. 2016.03; 4 (1): 5-11. ( PubMed, DOI )

  180. Taku Kobayashi, Yasuo Suzuki, Satoshi Motoya, Fumihito Hirai, Haruhiko Ogata, Hiroaki Ito, Noriko Sato, Kunihiko Ozaki, Mamoru Watanabe, Toshifumi Hibi. First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitis-results from a multicenter prospective randomized controlled trial and its post hoc analysis. J. Gastroenterol. 2016.03; 51 (3): 241-251. ( PubMed, DOI )

  181. Kengo Nozaki, Wakana Mochizuki, Yuka Matsumoto, Taichi Matsumoto, Masayoshi Fukuda, Tomohiro Mizutani, Mamoru Watanabe, Tetsuya Nakamura. Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes. J. Gastroenterol. 2016.03; 51 (3): 206-213. ( PubMed, DOI )

  182. Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shinji Tanaka, Sei Kakinuma, Miyako Murakawa, Sayuri Nitta, Takako Watanabe, Satoshi Otani, Miki Taniguchi, Fumio Goto, Hiroko Nagata, Shun Kaneko, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Seishin Azuma, Yasuhiro Itsui, Mina Nakagawa, Minoru Tanabe, Shinichi Takano, Mitsuharu Fukasawa, Minoru Sakamoto, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe. Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. J. Gastroenterol. 2016.03; 51 (5): 473-486. ( PubMed, DOI )

  183. Tetsuhide Ito, Hiroshi Ishiguro, Hirotaka Ohara, Terumi Kamisawa, Junichi Sakagami, Naohiro Sata, Yoshifumi Takeyama, Morihisa Hirota, Hiroyuki Miyakawa, Hisato Igarashi, Lingaku Lee, Takashi Fujiyama, Masayuki Hijioka, Keijiro Ueda, Yuichi Tachibana, Yoshio Sogame, Hiroaki Yasuda, Ryusuke Kato, Keisho Kataoka, Keiko Shiratori, Masanori Sugiyama, Kazuichi Okazaki, Shigeyuki Kawa, Yusuke Tando, Yoshikazu Kinoshita, Mamoru Watanabe, Tooru Shimosegawa. Evidence-based clinical practice guidelines for chronic pancreatitis 2015. J. Gastroenterol. 2016.02; 51 (2): 85-92. ( PubMed, DOI )

  184. Takashi Nagaishi, Taro Watabe, Nisha Jose, Arisa Tokai, Toshimitsu Fujii, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. Epithelial Nuclear Factor-κB Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis Digestion. 2016.01; 93 (1): 40-46. ( PubMed )

  185. Yasuhiro Asahina, Mamoru Watanabe. Need for appropriate programs for prevention of hepatitis B infection: Lessons from the latest nationwide survey in Japan. J. Gastroenterol. Hepatol. 2016.01; 31 (1): 12-13. ( PubMed, DOI )

  186. Satoshi Otani, Sei Kakinuma, Akihide Kamiya, Fumio Goto, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Fukiko Kawai-Kitahata, Sayuri Nitta, Toru Nakata, Ryuichi Okamoto, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Yasuhiro Asahina, Tomoyuki Yamaguchi, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Mamoru Watanabe. Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells. Biochem. Biophys. Res. Commun.. 2016.01; 469 (4): 1062-1068. ( PubMed, DOI )

  187. Ryuichi Okamoto, Mamoru Watanabe. Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease. J. Gastroenterol. 2016.01; 51 (1): 11-21. ( PubMed, DOI )

  188. Naoki Yoshimura, Mamoru Watanabe, Satoshi Motoya, Keiichi Tominaga, Katsuyoshi Matsuoka, Ryuichi Iwakiri, Kenji Watanabe, Toshifumi Hibi, . Safety and Efficacy of AJM300, an Oral Antagonist of α4 Integrin, in Induction Therapy for Patients With Active Ulcerative Colitis. Gastroenterology. 2015.12; 149 (7): 1775-1783.e2. ( PubMed, DOI )

  189. Severa Bunda, Kelly Burrell, Pardeep Heir, Lifan Zeng, Amir Alamsahebpour, Yoshihito Kano, Brian Raught, Zhong-Yin Zhang, Gelareh Zadeh, Michael Ohh. Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis. Nat Commun. 2015.11; 6 8859. ( PubMed, DOI )

  190. Yasuo Suzuki, Toshiyuki Matsui, Hiroaki Ito, Toshifumi Ashida, Shiro Nakamura, Satoshi Motoya, Takayuki Matsumoto, Noriko Sato, Kunihiko Ozaki, Mamoru Watanabe, Toshifumi Hibi. Circulating Interleukin 6 and Albumin, and Infliximab Levels Are Good Predictors of Recovering Efficacy After Dose Escalation Infliximab Therapy in Patients with Loss of Response to Treatment for Crohn's Disease: A Prospective Clinical Trial. Inflamm Bowel Dis. 2015.09; 21 (9): 2114-2122. ( PubMed, DOI )

  191. Shigeyuki Kawa, Kazuichi Okazaki, Kenji Notohara, Mamoru Watanabe, Tooru Shimosegawa. Autoimmune pancreatitis complicated with inflammatory bowel disease and comparative study of type 1 and type 2 autoimmune pancreatitis. J Gastroenterol. 2015.07; 50 (7): 805-815. ( PubMed, DOI )

  192. Katsuyoshi Matsuoka, Eiko Saito, Toshimitsu Fujii, Kento Takenaka, Maiko Kimura, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. Tacrolimus for the Treatment of Ulcerative Colitis. Intest Res. 2015.07; 13 (3): 219-226. ( PubMed, DOI )

  193. Ryuichi Okamoto, Mamoru Watanabe. Perspectives for Regenerative Medicine in the Treatment of Inflammatory Bowel Diseases. Digestion. 2015.07; 92 (2): 73-77. ( PubMed, DOI )

  194. Seishin Azuma, Yasuhiro Asahina, Yuki Nishimura-Sakurai, Sei Kakinuma, Shun Kaneko, Hiroko Nagata, Fumio Goto, Satoshi Ootani, Fukiko Kawai-Kitahata, Miki Taniguchi, Miyako Murakawa, Takako Watanabe, Megumi Tasaka-Fujita, Yasuhiro Itsui, Mina Nakagawa, Mamoru Watanabe. Efficacy of additional radiofrequency ablation after transcatheter arterial chemoembolization for intermediate hepatocellular carcinoma. Hepatol Res. 2015.07; 46 312-319. ( PubMed, DOI )

  195. Yu Matsuzawa, Shigeru Oshima, Masahiro Takahara, Chiaki Maeyashiki, Yasuhiro Nemoto, Masanori Kobayashi, Yoichi Nibe, Kengo Nozaki, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Averil Ma, Mamoru Watanabe. TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015.06; 11 (7): 1052-1062. ( PubMed, DOI )

  196. Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Naoya Sakamoto, Sayuri Nitta, Akiko Kusano-Kitazume, Takako Watanabe, Fukiko Kawai-Kitahata, Satoshi Otani, Miki Taniguchi, Fumio Goto, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Mamoru Watanabe. Impaired induction of interleukin 28B and expression of interferon λ 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C. J Gastroenterol Hepatol. 2015.06; 30 (6): 1075-1084. ( PubMed, DOI )

  197. Shintaro Akiyama, Tsunao Imamura, Rikako Koyama, Tetsuo Tamura, Yuko Koizumi, Kazuo Takeuchi. Adrenal Metastasis and Hemorrhage Secondary to Hepatocellular Carcinoma. Intern Med. 2015.06; 54 (12): 1513-1517. ( PubMed, DOI )

  198. Michio Onizawa, Shigeru Oshima, Ulf Schulze-Topphoff, Juan A Oses-Prieto, Timothy Lu, Rita Tavares, Thomas Prodhomme, Bao Duong, Michael I Whang, Rommel Advincula, Alex Agelidis, Julio Barrera, Hao Wu, Alma Burlingame, Barbara A Malynn, Scott S Zamvil, Averil Ma. The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 2015.06; 16 (6): 618-627. ( PubMed, DOI )

  199. Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Masakazu Nagahori, Toshimitsu Fujii, Eiko Saito, Tomoyuki Fujioka, Katsuyoshi Matsuoka, Makoto Naganuma, Mamoru Watanabe. Correlation of the Endoscopic and Magnetic Resonance Scoring Systems in the Deep Small Intestine in Crohn's Disease. Inflamm Bowel Dis. 2015.05; 21 (8): 1832-1838. ( PubMed, DOI )

  200. Keita Fukushima, Kiichiro Tsuchiya, Yoshihito Kano, Nobukatsu Horita, Shuji Hibiya, Ryohei Hayashi, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Shigeru Oshima, Takashi Nagaishi, Okamoto Ryuichi, Tetsuya Nakamura, Mamoru Watanabe. Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci. 2015.05; ( PubMed, DOI )

  201. Etsuko Iio, Kentaro Matsuura, Nao Nishida, Shinya Maekawa, Nobuyuki Enomoto, Mina Nakagawa, Naoya Sakamoto, Hiroshi Yatsuhashi, Masayuki Kurosaki, Namiki Izumi, Yoichi Hiasa, Naohiko Masaki, Tatsuya Ide, Keisuke Hino, Akihiro Tamori, Masao Honda, Shuichi Kaneko, Satoshi Mochida, Hideyuki Nomura, Shuhei Nishiguchi, Chiaki Okuse, Yoshito Itoh, Hitoshi Yoshiji, Isao Sakaida, Kazuhide Yamamoto, Hisayoshi Watanabe, Shuhei Hige, Akihiro Matsumoto, Eiji Tanaka, Katsushi Tokunaga, Yasuhito Tanaka. Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C. Hum Genet. 2015.03; 134 (3): 279-289. ( PubMed, DOI )

  202. Shinji Tanaka, Yusuke Saitoh, Takahisa Matsuda, Masahiro Igarashi, Takayuki Matsumoto, Yasushi Iwao, Yasumoto Suzuki, Hiroshi Nishida, Toshiaki Watanabe, Tamotsu Sugai, Ken-Ichi Sugihara, Osamu Tsuruta, Ichiro Hirata, Nobuo Hiwatashi, Hiroshi Saito, Mamoru Watanabe, Kentaro Sugano, Tooru Shimosegawa. Evidence-based clinical practice guidelines for management of colorectal polyps. J Gastroenterol. 2015.03; 50 (3): 252-260. ( PubMed, DOI )

  203. Mamoru Watanabe. Recent dramatic evolution of the Journal of Gastroenterology (JG): a note from current Editorial Director and former Editor-in-Chief of JG. J Gastroenterol. 2015.03; 50 (3): 249-251. ( PubMed, DOI )

  204. Anil Kumar Asthana, Antony B Friedman, Giovanni Maconi, Christian Maaser, Torsten Kucharzik, Mamoru Watanabe, Peter R Gibson. The failure of gastroenterologists to apply intestinal ultrasound in inflammatory bowel disease in the Asia-Pacific: a need for action. J Gastroenterol Hepatol. 2015.03; 30 (3): 446-452. ( PubMed, DOI )

  205. Yasuharu Maeda, Kazuo Ohtsuka, Shin-ei Kudo, Kunihiko Wakamura, Yuichi Mori, Noriyuki Ogata, Yoshiki Wada, Masashi Misawa, Akihiro Yamauchi, Seiko Hayashi, Toyoki Kudo, Takemasa Hayashi, Hideyuki Miyachi, Fuyuhiko Yamamura, Fumio Ishida, Haruhiro Inoue, Shigeharu Hamatani. Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis. World J Gastroenterol. 2015.02; 21 (7): 2108-2115. ( PubMed, DOI )

  206. Ulrike W Denzer, Thomas Rösch, Bilal Hoytat, Mohammed Abdel-Hamid, Xavier Hebuterne, Geoffroy Vanbiervielt, Jérôme Filippi, Haruiko Ogata, Naoki Hosoe, Kazuo Ohtsuka, Noriyuki Ogata, Keiichi Ikeda, Hiroyuki Aihara, Shin-Ei Kudo, Hisao Tajiri, Andras Treszl, Karl Wegscheider, Michel Greff, Jean-Francois Rey. Magnetically guided capsule versus conventional gastroscopy for upper abdominal complaints: a prospective blinded study. J Clin Gastroenterol. 2015.02; 49 (2): 101-107. ( PubMed, DOI )

  207. Masahiro Yoshida, Yoshikazu Kinoshita, Mamoru Watanabe, Kentaro Sugano. JSGE Clinical Practice Guidelines 2014: standards, methods, and process of developing the guidelines. J Gastroenterol. 2015.01; 50 (1): 4-10. ( PubMed, DOI )

  208. Shintaro Akiyama, Daisuke Kikuchi, Toshifumi Mitani, Takeshi Fujii, Akihiro Yamada, Akira Matsui, Osamu Ogawa, Toshiro Iizuka, Shu Hoteya, Mitsuru Kaise. A case of mucinous adenocarcinoma in the setting of chronic colitis associated with intestinal spirochetosis and intestinal stricture. Medicine (Baltimore). 2015.01; 94 (4): e493. ( PubMed, DOI )

  209. Bao H Duong, Michio Onizawa, Juan A Oses-Prieto, Rommel Advincula, Alma Burlingame, Barbara A Malynn, Averil Ma. A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity. Immunity. 2015.01; 42 (1): 55-67. ( PubMed, DOI )

  210. Yu Matsuzawa, Shigeru Oshima, Yoichi Nibe, Masanori Kobayashi, Chiaki Maeyashiki, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. Biochem Biophys Res Commun. 2015.01; 456 (1): 298-304. ( PubMed, DOI )

  211. Shintaro Akiyama, Tsunao Imamura, Tetsuo Tamura, Yuko Koizumi, Rikako Koyama, Kazuo Takeuchi, Goro Watanabe. Recurrent common bile duct stones composed of ursodeoxycholic acid: a report of four cases. Intern. Med. 2014.11; 53 (21): 2489-2492. ( PubMed )

  212. Shintaro Akiyama, Koji Izutsu, Yasunori Ota, Tsunao Imamura, Osamu Ogawa, Atsushi Wake, Kazuo Takeuchi. A case report of the histologic transformation of primary follicular lymphoma of the duodenum. Medicine (Baltimore). 2014.11; 93 (26): e165. ( PubMed, DOI )

  213. Shintaro Akiyama, Kenji Ikeda, Hitomi Sezaki, Taito Fukushima, Yushi Sorin, Yusuke Kawamura, Satoshi Saitoh, Tetsuya Hosaka, Norio Akuta, Masahiro Kobayashi, Fumitaka Suzuki, Yoshiyuki Suzuki, Yasuji Arase, Hiromitsu Kumada. Therapeutic effects of short- and intermediate-term tolvaptan administration for refractory ascites in patients with advanced liver cirrhosis.(Epub ahead of print) Hepatol. Res. 2014.11; ( PubMed, DOI )

  214. Mamoru Watanabe, Toshifumi Hibi, Nael M Mostafa, Jingdong Chao, Vipin Arora, Anne Camez, Joel Petersson, Roopal Thakkar. Long-term safety and efficacy of adalimumab in Japanese patients with moderate to severe Crohn's disease. J Crohns Colitis. 2014.11; 8 (11): 1407-1416. ( PubMed, DOI )

  215. Kiyonori Kobayashi, Fumihito Hirai, Makoto Naganuma, Kenji Watanabe, Takafumi Ando, Hiroshi Nakase, Katsuyoshi Matsuoka, Mamoru Watanabe. A randomized clinical trial of mesalazine suppository: The usefulness and problems of central review of evaluations of colonic mucosal findings. J Crohns Colitis. 2014.11; 8 (11): 1444-1453. ( PubMed, DOI )

  216. Yoshihito Kano, Sei Kakinuma, Fumio Goto, Seishin Azuma, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Mina Nakagawa, Atsushi Kudo, Minoru Tanabe, Susumu Kirimura, Tomonori Amano, Takashi Ito, Takumi Akashi, Yasuhiro Asahina, Mamoru Watanabe. Primary Hepatic Neuroendocrine Carcinoma with a Cholangiocellular Carcinoma Component in One Nodule. Clinical Journal of Gastroenterology. 2014.10; 7 449-454.

  217. Yoshihito Kano, Sei Kakinuma, Fumio Goto, Seishin Azuma, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Mina Nakagawa, Atsushi Kudo, Minoru Tanabe, Susumu Kirimura, Tomonori Amano, Takashi Ito, Takumi Akashi, Yasuhiro Asahina, Mamoru Watanabe. Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule. Clin J Gastroenterol. 2014.10; 7 (5): 449-454. ( PubMed, DOI )

  218. Xuan Li, Yun-Jia Zhao, Jun Dai, Xiao-Bo Li, Han-Bin Xue, Yao Zhang, Guang-Su Xiong, Kazuo Ohtsuka, Yun-Jie Gao, Qiang Liu, Yan Song, Jing-Yuan Fang, Zhi-Zheng Ge. Carbon dioxide insufflation improves the intubation depth and total enteroscopy rate in single-balloon enteroscopy: a randomised, controlled, double-blind trial. Gut. 2014.10; 63 (10): 1560-1565. ( PubMed, DOI )

  219. Nobukatsu Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Yoshihito Kano, Tomohiro Mizutani, Yasuhiro Nemoto, Shiro Yui, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt. Biochem Biophys Res Commun. 2014.10; 454 (4): 493-499. ( PubMed, DOI )

  220. Satoko Ohfuji, Wakaba Fukushima, Kenji Watanabe, Satoshi Sasaki, Hirokazu Yamagami, Masakazu Nagahori, Mamoru Watanabe, Yoshio Hirota. Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan. PLoS ONE. 2014.10; 9 (10): e110270. ( PubMed, DOI )

  221. Kaoru Tsuchiya, Yasuhiro Asahina, Masayuki Kurosaki, Nobuyuki Enomoto, Namiki Izumi. Reply: To PMID 24734314. Liver Transpl. 2014.09; 20 (9): 1152. ( PubMed, DOI )

  222. Shingo Usui, Naoki Hosoe, Katsuyoshi Matsuoka, Taku Kobayashi, Masaru Nakano, Makoto Naganuma, Yuka Ishibashi, Kayoko Kimura, Kazuaki Yoneno, Kazuhiro Kashiwagi, Tadakazu Hisamatsu, Nagamu Inoue, Hiroshi Serizawa, Toshifumi Hibi, Haruhiko Ogata, Takanori Kanai. Modified bowel preparation regimen for use in second-generation colon capsule endoscopy in patients with ulcerative colitis. Dig Endosc. 2014.09; 26 (5): 665-672. ( PubMed, DOI )

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  224. Norimasa Fukata, Kazuichi Okazaki, Mika Omiya, Mitsunobu Matsushita, Mamoru Watanabe. Hematologic malignancies in the Japanese patients with inflammatory bowel disease. J. Gastroenterol. 2014.09; 49 (9): 1299-1306. ( PubMed, DOI )

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  287. Funaoka Y, Sakamoto N, Nakagawa M, Kakinuma S, Suda G, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Watanabe M. Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91. J Virol. 2011; 85 5986-5994. ( PubMed, DOI )

  288. Ueyama M, Nakagawa M, Sakamoto N, Onozuka I, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Kitazume A, Murakawa M, Nishimura-Sakurai Y, Sekine-Osajima Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M:. Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-α2b plus ribavirin. Antiviral Therapy. 2011; 16 1081-1091. ( PubMed, DOI )

  289. Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N:. Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy. Hepatol Int. 2011; 5 789-799. ( PubMed, DOI )

  290. Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N. Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy. PLoS One. 2011; 6 e24514. ( PubMed, DOI )

  291. Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M. Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4. J Gastroenterol. 2011; 46 191-202.

  292. Hibi T, Sakuraba A, Watanabe M, Motoya S, Ito H, Motegi K, Kinouchi Y, Takazoe M, Suzuki Y, Matsumoto T, Kawakami K, Matsumoto T, Hirata I, Tanaka S, Ashida T, Matsui T. Retrieval of serum infliximab level by shortening the maintenance infusion interval is correlated with clinical efficacy in Crohn's disease. Inflamm Bowel Dis. 2011; 18 1480-1487. ( PubMed, DOI )

  293. Sakamoto N, Nakagawa M, Tanaka Y, Sekine-Osajima Y, Ueyama M, Kurosaki M, Nishida N, Tamori A, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Hige S, Ito Y, Tanaka E, Hiasa Y, Izumi N, Tokunaga K, Mizokami M, Watanabe M. Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b. J Med Virol. 2011; 83 871-878. ( PubMed, DOI )

  294. Naganuma M, Kunisaki R, Yoshimura N, Nagahori M, Yamamoto H, Kimura H, Sako M, Kawaguchi T, Takazoe M, Yamamoto S, Matsui T, Hibi T, Watanabe M. Conception and pregnancy outcome in women with inflammatory bowel disease: A multicentre study from Japan. J Crohns Colitis. 2011; 5 317-323. ( PubMed, DOI )

  295. Kurosaki M, Tanaka Y, Nishida N, Sugiyama M, Matsuura K, Asahina Y, Sugauchi F, Sakamoto N, Nakagawa M, Watanabe M, Sakai A, Honda M, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M. Pre-treatment prediction of response to pegylated-Interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors. J Hepatol. 2011; 54 439-448.

  296. Masakazu Nagahori, Sea Bong Hyun, Teruji Totsuka, Ryuichi Okamoto, Erika Kuwahara, Toru Takebayashi, Makoto Naganuma, Mamoru Watanabe. Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population. J. Gastroenterol. 2010.10; 45 (10): 1008-1013. ( PubMed, DOI )

  297. Junko Akiyama, Ryuichi Okamoto, Michiko Iwasaki, Xiu Zheng, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells. Biochem. Biophys. Res. Commun.. 2010.03; 393 (4): 662-667. ( PubMed, DOI )

  298. Michio Onizawa , Takashi Nagaishi , Takanori Kanai , Ken-ichi Nagano , Shigeru Oshima , Yasuhiro Nemoto , Atsushi Yoshioka , Teruji Totsuka , Ryuichi Okamoto , Tetsuya Nakamura , Naoya Sakamoto , Kiichiro Tsuchiya , Kazuhiro Aoki , Keiichi Ohya , Hideo Yagita , Mamoru Watanabe . Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2009.04; 296 (4): G850-9. ( PubMed, DOI )

  299. Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M. Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol. 2009.01; 296 (1): G23-35. ( PubMed, DOI )

  300. Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M. RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis J Immunol. 2009; 182 (10): 6079-6087. ( PubMed, DOI )

  301. Nemoto Y, Kanai T, Kameyama K, Shinohara T, Sakamoto N, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sudo T, Matsumoto S, Watanabe M. Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis J Immunol. 2009; 183 (8): 5059-5068. ( PubMed, DOI )

  302. Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M. Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein Hepatology. 2009; 50 1727-1737. ( PubMed, DOI )

  303. Atsushi Yoshioka, Ryuichi Okamoto, Shigeru Oshima, Junko Akiyama, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Mamoru Watanabe. Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells. Cytokine. 2008.10; 44 (1): 57-64. ( PubMed, DOI )

  304. Kimihiro Hino, Kiichiro Tsuchiya, Taro Fukao, Kotaro Kiga, Ryuichi Okamoto, Takanori Kanai, Mamoru Watanabe. Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation. RNA. 2008.07; 14 (7): 1433-1442. ( PubMed, DOI )

  305. Mikayo Aragaki, Kiichiro Tsuchiya, Ryuichi Okamoto, Sanae Yoshioka, Tetsuya Nakamura, Naoya Sakamoto, Takanori Kanai, Mamoru Watanabe. Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer. Biochem. Biophys. Res. Commun.. 2008.04; 368 (4): 923-929. ( PubMed, DOI )

  306. Y Ito, T Kanai, T Totsuka, R Okamoto, K Tsuchiya, Y Nemoto, A Yoshioka, T Tomita, T Nagaishi, N Sakamoto, T Sakanishi, K Okumura, H Yagita, M Watanabe. Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2008.01; 294 (1): G199-G207. ( PubMed, DOI )

  307. Sawada T, Nishiyama C, Kishi T, Sasazuki T, Komazawa-Sakon S, Xue X, Piao JH, Ogata H, Nakayama J, Taki T, Hayashi Y, Watanabe M, Yagita H, Okumura K, Nakano H. Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity J Biol Chem. 2008; 283 (39): 26820-26828. ( PubMed, DOI )

  308. Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M. MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis J Immunol. 2008; 180 (8): 5291-5299. ( PubMed )

  309. Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M. Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis J Immunol. 2008; 180 (1): 383-390. ( PubMed )

  310. Naoya Sakamoto, Mika Yoshimura, Tomomi Kimura, Keisuke Toyama, Yuko Sekine-Osajima, Mamoru Watanabe, Masaaki Muramatsu. Bone morphogenetic protein-7 and interferon-alpha synergistically suppress hepatitis C virus replicon. Biochem. Biophys. Res. Commun.. 2007.06; 357 (2): 467-473. ( PubMed, DOI )

  311. Nemoto Y, Kanai T, Makita S, Okamoto R, Totsuka T, Takeda K, Watanabe M. Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis Gastroenterology. 2007; 132 (1): 176-189. ( PubMed, DOI )

  312. Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M. Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer Gastroenterology. 2007; 132 (1): 208-220. ( PubMed, DOI )

  313. Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M. IL-7 Is essential for the development and the persistence of chronic colitis J Immunol. 2007; 178 (8): 4737-4748. ( PubMed )

  314. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M. Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation J Immunol. 2007; 178 (8): 4937-4946. ( PubMed )

  315. Ryuichi Okamoto, Tomoko Matsumoto, Mamoru Watanabe. Regeneration of the intestinal epithelia: regulation of bone marrow-derived epithelial cell differentiation towards secretory lineage cells. Hum. Cell. 2006.05; 19 (2): 71-75. ( PubMed, DOI )

  316. Ryuichi Okamoto, Mamoru Watanabe. Cellular and molecular mechanisms of the epithelial repair in IBD. Dig. Dis. Sci. 2005.10; 50 Suppl 1 S34-S38. ( PubMed, DOI )

  317. Mina Nakagawa, Naoya Sakamoto, Yoko Tanabe, Tomoyuki Koyama, Yasuhiro Itsui, Yoshie Takeda, Cheng-Hsin Chen, Sei Kakinuma, Shinya Oooka, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe. Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins. Gastroenterology. 2005.09; 129 (3): 1031-1041. ( PubMed, DOI )

  318. Matsumoto T, Okamoto R, Yajima T, Mori T, Okamoto S, Ikeda Y, Mukai M, Yamazaki M, Oshima S, Tsuchiya K, Nakamura T, Kanai T, Okano H, Inazawa J, Hibi T, Watanabe M. Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine Gastroenterology. 2005; 128 (7): 1851-1867. ( PubMed )

  319. Norio Maeda, Mamoru Watanabe, Susumu Okamoto, Takanori Kanai, Taketo Yamada, Jun-Ichi Hata, Nobumichi Hozumi, Asao Katsume, Hideko Nuriya, Jasbir Sandhu, Hiromasa Ishii, Michinori Kohara, Toshifumi Hibi. Hepatitis C virus infection in human liver tissue engrafted in mice with an infectious molecular clone. Liver Int.. 2004.06; 24 (3): 259-267. ( PubMed, DOI )

  320. Kawamura T, Kanai T, Dohi T, Uraushihara K, Totsuka T, Iiyama R, Taneda C, Yamazaki M, Nakamura T, Higuchi T, Aiba Y, Tsubata T, Watanabe M. Ectopic CD40 ligand expression on B cells triggers intestinal inflammation J Immunol. 2004.05; 172 (10): 6388-6397. ( PubMed )

  321. A Okazawa, T Kanai, K Nakamaru, T Sato, N Inoue, H Ogata, Y Iwao, M Ikeda, T Kawamura, S Makita, K Uraushihara, R Okamoto, M Yamazaki, M Kurimoto, H Ishii, M Watanabe, T Hibi. Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL-2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes. Clin. Exp. Immunol.. 2004.05; 136 (2): 269-276. ( PubMed, DOI )

  322. H Hagiyama, T Kubota, Y Komano, M Kurosaki, M Watanabe, N Miyasaka. Fulminant hepatitis in an asymptomatic chronic carrier of hepatitis B virus mutant after withdrawal of low-dose methotrexate therapy for rheumatoid arthritis. Clin. Exp. Rheumatol.. 2004.05; 22 (3): 375-376. ( PubMed )

  323. Yoko Tanabe, Naoya Sakamoto, Nobuyuki Enomoto, Masayuki Kurosaki, Eri Ueda, Shinya Maekawa, Tsuyoshi Yamashiro, Mina Nakagawa, Cheng-Hsin Chen, Nobuhiko Kanazawa, Sei Kakinuma, Mamoru Watanabe. Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon- alpha. J. Infect. Dis.. 2004.04; 189 (7): 1129-1139. ( PubMed, DOI )

  324. Tsuyoshi Yamashiro, Kazuyoshi Nagayama, Nobuyuki Enomoto, Hideki Watanabe, Tsuyoshi Miyagi, Hiroki Nakasone, Hiroshi Sakugawa, Mamoru Watanabe. Quantitation of the level of hepatitis delta virus RNA in serum, by real-time polymerase chain reaction--and its possible correlation with the clinical stage of liver disease. J. Infect. Dis.. 2004.04; 189 (7): 1151-1157. ( PubMed, DOI )

  325. Toshiro Sato, Takanori Kanai, Mamoru Watanabe, Atsushi Sakuraba, Susumu Okamoto, Takaaki Nakai, Akira Okazawa, Nagamu Inoue, Teruji Totsuka, Motomi Yamazaki, Richard A Kroczek, Tsuneo Fukushima, Hiromasa Ishii, Toshifumi Hibi. Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease. Gastroenterology. 2004.03; 126 (3): 829-839. ( PubMed )

  326. Kenichi Ishii, Takanori Kanai, Teruji Totsuka, Koji Uraushihara, Takahiro Ishikura, Motomi Yamazaki, Ryoici Okamoto, Akihiro Araki, Tatsuya Miyata, Katsuaki Tezuka, Tetsuya Nakamura, Mamoru Watanabe. Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis. J. Gastroenterol. Hepatol.. 2004.02; 19 (2): 174-181. ( PubMed )

  327. Ryuichi Okamoto, Mamoru Watanabe. Molecular and clinical basis for the regeneration of human gastrointestinal epithelia. J. Gastroenterol. 2004.01; 39 (1): 1-6. ( PubMed, DOI )

  328. Mina Nakagawa, Naoya Sakamoto, Nobuyuki Enomoto, Yoko Tanabe, Nobuhiko Kanazawa, Tomoyuki Koyama, Masayuki Kurosaki, Shinya Maekawa, Tsuyoshi Yamashiro, Cheng Hsin Chen, Yasuhiro Itsui, Sei Kakinuma, Mamoru Watanabe. Specific inhibition of hepatitis C virus replication by cyclosporin A. Biochem. Biophys. Res. Commun.. 2004.01; 313 (1): 42-47. ( PubMed )

  329. H Takenawa, M Kurosaki, N Enomoto, Y Miyasaka, N Kanazawa, N Sakamoto, T Ikeda, N Izumi, C Sato, M Watanabe. Differential gene-expression profiles associated with gastric adenoma. Br. J. Cancer. 2004.01; 90 (1): 216-223. ( PubMed, DOI )

  330. Kanazawa N, Kurosaki M, Sakamoto N, Enomoto N, Itsui Y, Yamashiro T, Tanabe Y, Maekawa S, Nakagawa M, Chen CH, Kakinuma S, Oshima S, Nakamura T, Kato T, Wakita T, Watanabe M. Regulation of hepatitis C virus replication by interferon regulatory factor 1 J Virol. 2004; 78 (18): 9713-9720. ( PubMed, DOI )

  331. Makita S, Kanai T, Oshima S, Uraushihara K, Totsuka T, Sawada T, Nakamura T, Koganei K, Fukushima T, Watanabe M. CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells J Immunol. 2004; 173 (5): 3119-3130. ( PubMed )

  332. Oshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, Kanai T, Handa H, Watanabe M. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells Mol Cell Biol. 2004; 24 (14): 6298-6310. ( PubMed, DOI )

  333. R Iiyama, T Kanai, K Uraushihara, T Ishikura, S Makita, T Totsuka, M Yamazaki, T Nakamura, T Miyata, H Yoshida, O Takeuchi, K Hoshino, K Takeda, H Ishikawa, S Akira, M Watanabe. Normal development of the gut-associated lymphoid tissue except Peyer's patch in MyD88-deficient mice. Scand. J. Immunol.. 2003.12; 58 (6): 620-627. ( PubMed )

  334. Hideki Watanabe, Kazuyoshi Nagayama, Nobuyuki Enomoto, Ryoko Chinzei, Tsuyoshi Yamashiro, Namiki Izumi, Hiroshi Yatsuhashi, Tatsunori Nakano, Betty H Robertson, Hiroki Nakasone, Hiroshi Sakugawa, Mamoru Watanabe. Chronic hepatitis delta virus infection with genotype IIb variant is correlated with progressive liver disease. J. Gen. Virol.. 2003.12; 84 (Pt 12): 3275-3289. ( PubMed, DOI )

  335. Yuka Miyasaka, Nobuyuki Enomoto, Masayuki Kurosaki, Naoya Sakamoto, Nobuhiko Kanazawa, Takahiro Kohashi, Eri Ueda, Shinya Maekawa, Hideki Watanabe, Namiki Izumi, Chifumi Sato, Mamoru Watanabe. Hepatitis C virus nonstructural protein 5A inhibits tumor necrosis factor-alpha-mediated apoptosis in Huh7 cells. J. Infect. Dis.. 2003.11; 188 (10): 1537-1544. ( PubMed, DOI )

  336. N Dan, T Kanai, T Totsuka, R Iiyama, M Yamazaki, T Sawada, T Miyata, H Yagita, K Okumura, M Watanabe. Ameliorating effect of anti-Fas ligand MAb on wasting disease in murine model of chronic colitis. Am. J. Physiol. Gastrointest. Liver Physiol.. 2003.10; 285 (4): G754-G760. ( PubMed, DOI )

  337. S Makita, T Kanai, S Matsumoto, R Iiyama, K Uraushihara, T Totsuka, M Yamazaki, T Nakamura, H Ishikawa, M Watanabe. The role of cryptopatch-derived intraepithelial lymphocytes in the development of chronic ileocecitis. Scand. J. Immunol.. 2003.10; 58 (4): 428-435. ( PubMed )

  338. Yasutoshi Toriumi, Megumi Hiraoka, Mamoru Watanabe, Masayuki Yoshida. Pioglitazone reduces monocyte adhesion to vascular endothelium under flow by modulating RhoA GTPase and focal adhesion kinase. FEBS Lett.. 2003.10; 553 (3): 419-422. ( PubMed )

  339. Okamoto R, Watanabe M. Prospects for regeneration of gastrointestinal epithelia with donor derived cells. Trends Mol Med. 2003.09; 9 (7): 286-290.

  340. Yamazaki M, Yajima T, Tanabe M, Fukui K, Okada E, Okamoto R, Oshima S, Nakamura T, Kanai T, Uehira M, Takeuchi T, Ishikawa H, Hibi T, Watanabe M. Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis J Immunol. 2003.08; 171 (3): 1556-1563. ( PubMed )

  341. H Takagi, T Kanai, A Okazawa, Y Kishi, T Sato, H Takaishi, N Inoue, H Ogata, Y Iwao, K Hoshino, K Takeda, S Akira, M Watanabe, H Ishii, T Hibi. Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice. Scand. J. Gastroenterol.. 2003.08; 38 (8): 837-844. ( PubMed )

  342. Takayuki Ota, Masayuki Amagai, Mamoru Watanabe, Takeji Nishikawa. No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases. J. Dermatol. Sci.. 2003.08; 32 (2): 137-141. ( PubMed )

  343. Hideki Watanabe, Kazuyoshi Nagayama, Nobuyuki Enomoto, Jun Itakura, Yoko Tanabe, Chifumi Sato, Namiki Izumi, Mamoru Watanabe. Amino acid substitutions in PKR-eIF2 phosphorylation homology domain (PePHD) of hepatitis C virus E2 protein in genotype 2a/2b and 1b in Japan and interferon efficacy. Hepatol. Res.. 2003.08; 26 (4): 268-274. ( PubMed )

  344. Takahiro Ishikura, Takanori Kanai, Koji Uraushihara, Ryoichi Iiyama, Shin Makita, Teruji Totsuka, Motomi Yamazaki, Taisuke Sawada, Tetsuya Nakamura, Tatsuya Miyata, Tetsuji Kitahora, Toshifumi Hibi, Tomoaki Hoshino, Mamoru Watanabe. Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice. J. Gastroenterol. Hepatol.. 2003.08; 18 (8): 960-969. ( PubMed )

  345. Uraushihara K, Kanai T, Ko K, Totsuka T, Makita S, Iiyama R, Nakamura T, Watanabe M. Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells J Immunol. 2003.07; 171 (2): 708-716. ( PubMed )

  346. Ezaki T, Watanabe M, Inoue N, Kanai T, Ogata H, Iwao Y, Ishii H, Hibi T. A specific genetic alteration on chromosome 6 in ulcerative colitis-associated colorectal cancers Cancer Res. 2003.07; 63 (13): 3747-3749. ( PubMed )

  347. R Iiyama, T Kanai, K Uraushihara, T Totsuka, T Nakamura, T Miyata, H Yagita, A Kushi, K Suzuki, K Tezuka, M Watanabe. The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches. Immunol. Lett.. 2003.07; 88 (1): 63-70. ( PubMed )

  348. Hideki Watanabe, Kazuyoshi Nagayama, Nobuyuki Enomoto, Jun Itakura, Yoko Tanabe, Kosei Hamano, Namiki Izumi, Chifumi Sato, Mamoru Watanabe. Sequence elements correlating with circulating viral load in genotype 1b hepatitis C virus infection. Virology. 2003.07; 311 (2): 376-383. ( PubMed )

  349. Yokota T, Sakamoto N, Enomoto N, Tanabe Y, Miyagishi M, Maekawa S, Yi L, Kurosaki M, Taira K, Watanabe M, Mizusawa H. Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs EMBO Rep. 2003.06; 4 (6): 602-608. ( PubMed, DOI )

  350. T Totsuka, T Kanai, K Uraushihara, R Iiyama, M Yamazaki, H Akiba, H Yagita, K Okumura, M Watanabe. Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis. Am. J. Physiol. Gastrointest. Liver Physiol.. 2003.04; 284 (4): G595-G603. ( PubMed, DOI )

  351. Sei Kakinuma, Yujiro Tanaka, Ryoko Chinzei, Mamoru Watanabe, Keiko Shimizu-Saito, Yuzuru Hara, Kenichi Teramoto, Shigeki Arii, Chifumi Sato, Kozo Takase, Takehiko Yasumizu, Hirobumi Teraoka. Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells. 2003.04; 21 (2): 217-227. ( PubMed, DOI )

  352. Kiichiro Tsuchiya, Youhei Kawano, Toshiyuki Kojima, Kisaburo Nagata, Toshifumi Takao, Masato Okada, Hisaaki Shinohara, Kazushige Maki, Noriko Toyama-Sorimachi, Nobuyuki Miyasaka, Mamoru Watanabe, Hajime Karasuyama. Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS Lett.. 2003.02; 537 (1-3): 203-209. ( PubMed )

  353. Totsuka T, Kanai T, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, Watanabe M. Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis Gastroenterology. 2003; 124 (2): 410-421. ( PubMed, DOI )

  354. Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation J Immunol. 2003; 171 (8): 4156-4163. ( PubMed )

  355. Okamoto R, Watanabe M. Prospects for regeneration of gastrointestinal epithelia using bone-marrow cells Trends in molecular medicine. 2003; 9 (7): 286-290. ( PubMed )

  356. Akira Okazawa, Takanori Kanai, Mamoru Watanabe, Motomi Yamazaki, Nagamu Inoue, Masao Ikeda, Masashi Kurimoto, Hiromasa Ishii, Toshifumi Hibi. Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement. Am. J. Gastroenterol.. 2002.12; 97 (12): 3108-3117. ( PubMed, DOI )

  357. Okamoto R, Yajima T, Yamazaki M, Kanai T, Mukai M, Okamoto S, Ikeda Y, Hibi T, Inazawa J, Watanabe M. Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract Nat Med. 2002.09; 8 (9): 1011-1017. ( PubMed, DOI )

  358. Nobuhiko Kanazawa, Namiki Izumi, Kaoru Tsuchiya, Kaoru Sakurai, Kosei Hamano, Jun Itakura, Yasuhiro Asahina, Osamu Noguchi, Masakatsu Uchihara, Shozo Miyake, Naoto Miyakawa, Yasuhiro Kawachi, Hidetoshi Shiotsu, Kazuhiro Taki, Yoshiro Himeno, Nobuyuki Enomoto, Mamoru Watanabe, Takahiro Sakai. A case of primary leiomyoma of the liver in a patient without evidence of immunosuppression. Hepatol. Res.. 2002.09; 24 (1): 80. ( PubMed )

  359. Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, Katano M, Tanaka M, Watanabe M, Yagita H, Okumura K, Nakano H. Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death J Biol Chem. 2002.08; 277 (32): 28853-28860. ( PubMed, DOI )

  360. K Kobayashi, H Ogata, M Morikawa, S Iijima, N Harada, T Yoshida, W R Brown, N Inoue, Y Hamada, H Ishii, M Watanabe, T Hibi. Distribution and partial characterisation of IgG Fc binding protein in various mucin producing cells and body fluids. Gut. 2002.08; 51 (2): 169-176. ( PubMed )

  361. Keiichi Ono, Yujiro Tanaka, Fumihiko Kusano, Sei Kakinuma, Kozo Ishidate, Mamoru Watanabe, Fumiaki Marumo, Chifumi Sato. Fas-ligand and perforin expression in infiltrating cytotoxic T lymphocytes in the liver of chronic hepatitis C. Hepatol. Res.. 2002.07; 23 (3): 153-162. ( PubMed )

  362. Ryoko Chinzei, Yujiro Tanaka, Keiko Shimizu-Saito, Yuzuru Hara, Sei Kakinuma, Mamoru Watanabe, Kenichi Teramoto, Shigeki Arii, Kozo Takase, Chifumi Sato, Naohiro Terada, Hirobumi Teraoka. Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology. 2002.07; 36 (1): 22-29. ( PubMed, DOI )

  363. Makoto Naganuma, Mamoru Watanabe, Takanori Kanai, Yasushi Iwao, Makio Mukai, Hiromasa Ishii, Toshifumi Hibi. Characterization of structures with T-lymphocyte aggregates in ileal villi of Crohn's disease. Am. J. Gastroenterol.. 2002.07; 97 (7): 1741-1747. ( PubMed, DOI )

  364. T Kanai, M Watanabe, A Okazawa, T Sato, M Yamazaki, S Okamoto, H Ishii, T Totsuka, R Iiyama, R Okamoto, M Ikeda, M Kurimoto, K Takeda, S Akira, T Hibi. Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology. 2001.10; 121 (4): 875-888. ( PubMed )

  365. T Sawada, M Yoshida, Y Yasukouchi, M Watanabe, F Numano. Colon cancer cell adhesion to endothelial E-selectin inhibits detachment of endothelial cells through activation of beta(1)-integrin. Biochem. Biophys. Res. Commun.. 2001.08; 286 (1): 20-27. ( PubMed, DOI )

  366. Inoue N, Watanabe M, Sato T, Okazawa A, Yamazaki M, Kanai T, Ogata H, Iwao Y, Ishii H, Hibi T. Restricted V(H) gene usage in lamina propria B cells producing anticolon antibody from patients with ulcerative colitis Gastroenterology. 2001.07; 121 (1): 15-23. ( PubMed )

  367. Y Miyasaka, N Enomoto, K Nagayama, N Izumi, F Marumo, M Watanabe, C Sato. Analysis of differentially expressed genes in human hepatocellular carcinoma using suppression subtractive hybridization. Br. J. Cancer. 2001.07; 85 (2): 228-234. ( PubMed, DOI )

  368. K Nagayama, N Enomoto, Y Miyasaka, M Kurosaki, C H Chen, N Sakamoto, M Nakagawa, C Sato, J Tazawa, T Ikeda, N Izumi, M Watanabe. Overexpression of interferon gamma-inducible protein 10 in the liver of patients with type I autoimmune hepatitis identified by suppression subtractive hybridization. Am. J. Gastroenterol.. 2001.07; 96 (7): 2211-2217. ( PubMed, DOI )

  369. T Nomura, T Ohkusa, A Araki, Y Chuganji, M Momoi, I Takashimizu, M Watanabe. Influence of climatic factors in the incidence of upper gastrointestinal bleeding. J. Gastroenterol. Hepatol.. 2001.06; 16 (6): 619-623. ( PubMed )

  370. H Watanabe, N Enomoto, K Nagayama, N Izumi, F Marumo, C Sato, M Watanabe. Number and position of mutations in the interferon (IFN) sensitivity-determining region of the gene for nonstructural protein 5A correlate with IFN efficacy in hepatitis C virus genotype 1b infection. J. Infect. Dis.. 2001.04; 183 (8): 1195-1203. ( PubMed, DOI )

  371. T Horiuchi, T Ohkusa, M Watanabe, D Kobayashi, H Miwa, Y Eishi. Helicobacter pylori DNA in drinking water in Japan. Microbiol. Immunol.. 2001.04; 45 (7): 515-519. ( PubMed )

  372. H Ohbayashi, Y Tanaka, S Ohoka, R Chinzei, S Kakinuma, M Goto, M Watanabe, F Marumo, C Sato. TT virus is shown in the liver by in situ hybridization with a PCR-generated probe from the serum TTV-DNA. J. Gastroenterol. Hepatol.. 2001.04; 16 (4): 424-428. ( PubMed )

  373. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y, Yokoyama T, Watanabe M. Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated Ann Intern Med. 2001.03; 134 (5): 380-386. ( PubMed )

  374. Kanai T, Watanabe M, Okazawa A, Nakamaru K, Okamoto M, Naganuma M, Ishii H, Ikeda M, Kurimoto M, Hibi T. Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease Gastroenterology. 2000.12; 119 (6): 1514-1523. ( PubMed )

  375. Suzuki K, Oida T, Hamada H, Hitotsumatsu O, Watanabe M, Hibi T, Yamamoto H, Kubota E, Kaminogawa S, Ishikawa H. Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis Immunity. 2000.11; 13 (5): 691-702. ( PubMed )

  376. M Naganuma, Y Iwao, N Inoue, T Hisamatsu, H Imaeda, H Ishii, T Kanai, M Watanabe, T Hibi. Analysis of clinical course and long-term prognosis of surgical and nonsurgical patients with intestinal Behçet's disease. Am. J. Gastroenterol.. 2000.10; 95 (10): 2848-2851. ( PubMed, DOI )

  377. K Kashiwagi, M Watanabe, T Ezaki, T Kanai, H Ishii, M Mukai, T Hibi. Clinical usefulness of microsatellite instability for the prediction of gastric adenoma or adenocarcinoma in patients with chronic gastritis. Br. J. Cancer. 2000.06; 82 (11): 1814-1818. ( PubMed, DOI )

  378. T Kanai, M Watanabe, A Hayashi, A Nakazawa, T Yajima, A Okazawa, M Yamazaki, H Ishii, T Hibi. Regulatory effect of interleukin-4 and interleukin-13 on colon cancer cell adhesion. Br. J. Cancer. 2000.05; 82 (10): 1717-1723. ( PubMed, DOI )

  379. H Takaishi, S Ohara, K Hotta, T Yajima, T Kanai, N Inoue, Y Iwao, M Watanabe, H Ishii, T Hibi. Circulating autoantibodies against purified colonic mucin in ulcerative colitis. J. Gastroenterol.. 2000.04; 35 (1): 20-27. ( PubMed )

  380. A Matsui, T Ikeda, K Enomoto, K Hosoda, H Nakashima, K Omae, M Watanabe, T Hibi, M Kitajima. Increased formation of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes. Cancer Lett.. 2000.04; 151 (1): 87-95. ( PubMed )

  381. A Matsui, T Ikeda, K Enomoto, H Nakashima, K Omae, M Watanabe, T Hibi, M Kitajima. Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-O-methyltransferase. Cancer Lett.. 2000.03; 150 (1): 23-31. ( PubMed )

  382. Hisamatsu T, Watanabe M, Ogata H, Ezaki T, Hozawa S, Ishii H, Kanai T, Hibi T. Interferon-inducible gene family 1-8U expression in colitis-associated colon cancer and severely inflamed mucosa in ulcerative colitis Cancer Res. 1999.12; 59 (23): 5927-5931. ( PubMed )

  383. Nakazawa A, Watanabe M, Kanai T, Yajima T, Yamazaki M, Ogata H, Ishii H, Azuma M, Hibi T. Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa Gastroenterology. 1999.09; 117 (3): 536-545. ( PubMed )

  384. Kohyama M, Nanno M, Kawaguchi-Miyashita M, Shimada S, Watanabe M, Hibi T, Kaminogawa S, Ishikawa H. Cytolytic and IFN-gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are T cell receptor-beta-chain dependent Proc Natl Acad Sci USA. 1999.06; 96 (13): 7451-7455. ( PubMed )

  385. Y Yonamine, M Watanabe, F Kinjo, T Hibi. Generation of MHC class I-restricted cytotoxic T cell lines and clones against colonic epithelial cells from ulcerative colitis. J. Clin. Immunol.. 1999.01; 19 (1): 77-85. ( PubMed )

  386. S Okamoto, M Watanabe, M Yamazaki, T Yajima, T Hayashi, H Ishii, M Mukai, T Yamada, N Watanabe, B A Jameson, T Hibi. A synthetic mimetic of CD4 is able to suppress disease in a rodent model of immune colitis. Eur. J. Immunol.. 1999.01; 29 (1): 355-366. ( PubMed, DOI )

  387. M Watanabe, Y Hosoda, S Okamoto, M Yamazaki, N Inoue, Y Ueno, Y Iwao, H Ishii, N Watanabe, Y Hamada, T Yamada, T Suzuki, T Hibi. CD45RChighCD4+ intestinal mucosal lymphocytes infiltrating in the inflamed colonic mucosa of a novel rat colitis model induced by TNB immunization. Clin. Immunol. Immunopathol.. 1998.07; 88 (1): 46-55. ( PubMed )

  388. T Yajima, H Takaishi, T Kanai, Y Iwao, M Watanabe, H Ishii, T Hibi. Predictive factors of response to leukocytapheresis therapy for ulcerative colitis. Ther Apher. 1998.05; 2 (2): 115-119. ( PubMed )

  389. Watanabe M, Ueno Y, Yajima T, Okamoto S, Hayashi T, Yamazaki M, Iwao Y, Ishii H, Habu S, Uehira M, Nishimoto H, Ishikawa H, Hata J, Hibi T. Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa J Exp Med. 1998.02; 187 (3): 389-402. ( PubMed )

  390. M Watanabe, N Watanabe, Y Iwao, H Ogata, T Kanai, Y Ueno, M Tsuchiya, H Ishii, S Aiso, S Habu, T Hibi. The serum factor from patients with ulcerative colitis that induces T cell proliferation in the mouse thymus is interleukin-7. J. Clin. Immunol.. 1997.07; 17 (4): 282-292. ( PubMed )

  391. M Watanabe, A Hayashi, Y Hosoda, M Ohara, Y Iwao, H Ishii, H Ishikawa, M Nanno, T Hibi. Preferential activation of CD4+V beta 5.2/5.3+ intestinal intraepithelial lymphocytes in the inflamed lesions of Crohn's disease. Clin. Immunol. Immunopathol.. 1996.02; 78 (2): 130-139. ( PubMed )

  392. T Ezaki, A Yanagisawa, K Ohta, S Aiso, M Watanabe, T Hibi, Y Kato, T Nakajima, T Ariyama, J Inazawa, Y Nakamura, A Horii. Deletion mapping on chromosome 1p in well-differentiated gastric cancer. Br. J. Cancer. 1996.02; 73 (4): 424-428. ( PubMed )

  393. Watanabe M, Ueno Y, Yajima T, Iwao Y, Tsuchiya M, Ishikawa H, Aiso S, Hibi T, Ishii H. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes J Clin Invest. 1995.06; 95 (6): 2945-2953. ( PubMed, DOI )

  394. M Ohara, T Hibi, N Watanabe, K Kobayashi, H Takaishi, A Hayashi, Y Hosoda, K Toda, Y Iwao, M Watanabe. Immunoglobulin G subclass distribution of human anticolon antibodies in ulcerative colitis. J. Gastroenterol. Hepatol.. 1995.03; 10 (2): 158-164. ( PubMed )

  395. H Suzuki, T Hibi, M Oda, Y Hosoda, M Mori, S Miura, S Tanaka, M Watanabe, M Tsuchiya. Sulfhydryl blocker-induced colitis in the rat: immunological changes in thymus gland and colonic mucosa. J. Gastroenterol. Hepatol.. 1994.11; 9 (6): 544-550. ( PubMed )

  396. T Hibi, M Ohara, K Kobayashi, W R Brown, K Toda, H Takaishi, Y Hosoda, A Hayashi, Y Iwao, M Watanabe. Enzyme linked immunosorbent assay (ELISA) and immunoprecipitation studies on anti-goblet cell antibody using a mucin producing cell line in patients with inflammatory bowel disease. Gut. 1994.02; 35 (2): 224-230. ( PubMed )

  397. M Watanabe, Y Sugino, Y Imai, K Kumai, T Hibi, K Hiramatsu, M Kitajima, M Tsuchiya. Revaluation of endoscopic laser therapy for treatment of early cancer in the stomach. Keio J Med. 1993.12; 42 (4): 206-208. ( PubMed )

  398. T Kanai, T Hibi, A Hayashi, J Takashima, M Shiozawa, S Aiso, K Toda, Y Iwao, M Watanabe, M Tsuchiya. Carcinoembryonic antigen mediates in vitro cell aggregation induced by interferon-gamma in a human colon cancer cell line: requirement for active metabolism and intact cytoskeleton. Cancer Lett.. 1993.07; 71 (1-3): 109-117. ( PubMed )

  399. T Hibi, M Ohara, M Watanabe, T Kanai, H Takaishi, A Hayashi, Y Hosoda, H Ogata, Y Iwao, S Aiso. Interleukin 2 and interferon-gamma augment anticolon antibody dependent cellular cytotoxicity in ulcerative colitis. Gut. 1993.06; 34 (6): 788-793. ( PubMed )

  400. A Hara, T Hibi, M Yoshioka, A Hayashi, K Toda, T Suzuki, Y Kameda, F Ueda, M Watanabe, M Tsuchiya. Quantitative analysis of intercellular communication in colon cancer cells (Caco-2) by the scrape-loading/dye transfer assay. Gastroenterol. Jpn.. 1992.08; 27 (4): 560. ( PubMed )

  401. N L Letvin, Z W Chen, H Yamamoto, M Watanabe. Active immune therapy for the treatment of HIV infections. AIDS Res. Hum. Retroviruses. 1992.08; 8 (8): 1499. ( PubMed, DOI )

  402. Y Iwao, T Hibi, M Watanabe, H Takaishi, Y Hosoda, A Hayashi, M Ohara, H Ogata, S Aiso, K Toda. The mechanism of action of serum immunosuppressive factor in Crohn's disease: it blocks the growth of mitogen-stimulated lymphocytes in early G1 phase through an inhibition of transferrin receptor expression. J Clin Lab Immunol. 1992.04; 38 (1): 15-27. ( PubMed )

  403. Hasunuma T, Tsubota H, Watanabe M, Chen ZW, Lord CI, Burkly LC, Daley JF, Letvin NL. Regions of the CD4 molecule not involved in virus binding or syncytia formation are required for HIV-1 infection of lymphocytes J Immunol. 1992.03; 148 (6): 1841-1846. ( PubMed )

  404. Watanabe M, Boyson JE, Lord CI, Letvin NL. Chimpanzees immunized with recombinant soluble CD4 develop anti-self CD4 antibody responses with anti-human immunodeficiency virus activity Proc Natl Acad Sci USA. 1992.01; 89 (11): 5103-5107. ( PubMed )

  405. M Tsuchiya, T Hibi, M Watanabe, M Ohara, H Ogata, Y Iwao, N Watanabe, S Aiso, H Asakura, H Yoshimatsu. Thymectomy in ulcerative colitis: a report of cases over a 13 year period. Thymus. 1991.03; 17 (2): 67-73. ( PubMed )

  406. Watanabe M, Ringler DJ, Fultz PN, MacKey JJ, Boyson JE, Levine CG, Letvin NL. A chimpanzee-passaged human immunodeficiency virus isolate is cytopathic for chimpanzee cells but does not induce disease J Virol. 1991.01; 65 (6): 3344-3348. ( PubMed )

  407. Watanabe M, Chen ZW, Tsubota H, Lord CI, Levine CG, Letvin NL. Soluble human CD4 elicits an antibody response in rhesus monkeys that inhibits simian immunodeficiency virus replication Proc Natl Acad Sci USA. 1991.01; 88 (1): 120-124. ( PubMed )

  408. Watanabe M, Levine CG, Shen L, Fisher RA, Letvin NL. Immunization of simian immunodeficiency virus-infected rhesus monkeys with soluble human CD4 elicits an antiviral response Proc Natl Acad Sci USA. 1991.01; 88 (11): 4616-4620. ( PubMed )

  409. T Hibi, M Ohara, K Toda, A Hara, H Ogata, Y Iwao, N Watanabe, M Watanabe, Y Hamada, K Kobayashi. In vitro anticolon antibody production by mucosal or peripheral blood lymphocytes from patients with ulcerative colitis. Gut. 1990.12; 31 (12): 1371-1376. ( PubMed )

  410. Watanabe M, Ringler DJ, Nakamura M, DeLong PA, Letvin NL. Simian immunodeficiency virus inhibits bone marrow hematopoietic progenitor cell growth J Virol. 1990.02; 64 (2): 656-663. ( PubMed )

  411. M Watanabe, T Hibi, Y Iwao, T Kanai, M Ohara, T Fujisawa, H Ogata, N Watanabe, H Asakura, S Aiso. Release of the serum immunosuppressive factor by monocytes in patients with Crohn's disease. J Clin Lab Immunol. 1989.08; 29 (4): 161-166. ( PubMed )

  412. Watanabe M, Reimann KA, DeLong PA, Liu T, Fisher RA, Letvin NL. Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques Nature. 1989.01; 337 (6204): 267-270. ( PubMed, DOI )

  413. T Kitahora, K Suzuki, H Asakura, T Yoshida, M Suematsu, M Watanabe, S Aiso, M Tsuchiya. Active oxygen species generated by monocytes and polymorphonuclear cells in Crohn's disease. Dig. Dis. Sci.. 1988.08; 33 (8): 951-955. ( PubMed )

  414. K Kobayashi, H Asakura, Y Hamada, T Hibi, M Watanabe, T Yoshida, N Watanabe, S Miura, S Aiso, M Tsuchiya. T lymphocyte subpopulations and immunoglobulin-containing cells in the colonic mucosa of ulcerative colitis; a morphometric and immunohistochemical study. J Clin Lab Immunol. 1988.02; 25 (2): 63-68. ( PubMed )

  415. M Suematsu, M Suzuki, T Kitahora, S Miura, K Suzuki, T Hibi, M Watanabe, H Nagata, H Asakura, M Tsuchiya. Increased respiratory burst of leukocytes in inflammatory bowel diseases--the analysis of free radical generation by using chemiluminescence probe. J Clin Lab Immunol. 1987.11; 24 (3): 125-128. ( PubMed )

  416. M Watanabe, S Aiso, T Hibi, N Watanabe, Y Iwao, T Yoshida, H Asakura, S Tsuru, M Tsuchiya. Alteration of T cell maturation and proliferation in the mouse thymus induced by serum factors from patients with ulcerative colitis. Clin. Exp. Immunol.. 1987.06; 68 (3): 596-604. ( PubMed )

  417. M Suematsu, M Suzuki, S Miura, H Nagata, C Oshio, H Asakura, M Watanabe, M Tsuchiya. Sulfasalazine and its metabolites attenuate respiratory burst of leukocytes--a possible mechanism of anti-inflammatory effects. J Clin Lab Immunol. 1987.05; 23 (1): 31-33. ( PubMed )

  418. M Watanabe, S Tsuru, Y Zinnaka, T Yoshida, S Aiso, T Hibi, H Asakura, M Tsuchiya. Demonstration and characterization of immunosuppressive factors in sera from patients with Crohn's disease. J Clin Lab Immunol. 1985.05; 17 (1): 13-19. ( PubMed )

  419. S Tsuru, M Matsuguchi, M Watanabe, M Taniguchi, Y Zinnaka. Entrance of cholera enterotoxin subunits into thymus cells. J. Histochem. Cytochem.. 1984.12; 32 (12): 1275-1279. ( PubMed, DOI )

  420. H Kitani, S Tsuru, M Oguchi, M Watanabe, Y Zinnaka. Effect of PSK on interferon production in tumor-bearing mice. J Clin Lab Immunol. 1984.12; 15 (4): 211-214. ( PubMed )

  421. M Watanabe, S Tsuru, S Aiso, T Hibi, T Yoshida, H Asakura, Y Zinnaka, M Tsuchiya. Induction of impaired activation of lymphocytes by suppressive factor in Crohn's disease patients. J Clin Lab Immunol. 1984.05; 14 (1): 29-34. ( PubMed )

  422. S Tsuru, K Nomoto, M Taniguchi, H Kitani, M Watanabe, Y Zinnaka. Depression of macrophage functions and T-cell-mediated immunity to listeria infection in tumor-bearing mice and its prevention by PSK. Cancer Immunol. Immunother.. 1984.04; 18 (3): 160-163. ( PubMed )

  423. S Aiso, T Yoshida, M Watanabe, T Hibi, H Asakura, M Tsuchiya, S Tsuru. Characterization of thymus cells in hyperplastic thymuses in patients with myasthenia gravis and ulcerative colitis with monoclonal antibodies. J Clin Lab Immunol. 1984.03; 13 (3): 137-139. ( PubMed )

  424. T Hibi, S Aiso, M Ishikawa, M Watanabe, T Yoshida, K Kobayashi, H Asakura, S Tsuru, M Tsuchiya. Circulating antibodies to the surface antigens on colon epithelial cells in ulcerative colitis. Clin. Exp. Immunol.. 1983.10; 54 (1): 163-168. ( PubMed )

  425. S Aiso, M Watanabe, T Hibi, T Yoshida, M Tsuchiya, S Tsuru. Characterization of immunoregulatory T cells and lymphocytophilic antibodies in ulcerative colitis: analysis with monoclonal antibodies. J Clin Lab Immunol. 1982.11; 9 (2): 109-112. ( PubMed )

  426. T Hibi, S Aiso, T Yoshida, M Watanabe, H Asakura, S Tsuru, M Tsuchiya. Anti-colon antibody and lymphocytophilic antibody in ulcerative colitis. Clin. Exp. Immunol.. 1982.07; 49 (1): 75-80. ( PubMed )

  427. H Asakura, M Tsuchiya, S Aiso, M Watanabe, K Kobayashi, T Hibi, K Ando, H Takata, S Sekiguchi. Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis. Gastroenterology. 1982.03; 82 (3): 413-418. ( PubMed )

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Books etc 【 display / non-display

  1. Masakazu Nagahori. Diagnosis of Ulcerative Colitis:Typical Findings and Diagnostic Criteria. Springer, 2018.11 Part Ⅱ Endoscopic Diagnosis of IBD

  2. Mamoru Watanabe. Endoscopy in Inflammatory Bowel Disease: Asian Perspectives with Respect toJapan. Springer, 2018.11 Part Ⅳ Endoscopy in IBD: International Difference

  3. Nagaishi T, Watanabe M. Crohn's Disease and Ulcerative Colitis: from Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach.. 2017.03 Paradigm of T cell differentiation in IBD: Crohn's disease and ulcerative colitis (ISBN : 978-3-319-33701-2)

Conference Activities & Talks 【 display / non-display

  1. Mone Fushimi, Tadahiko Inoue, Daiki Yamada, Taro Watabe, Mamoru Watanabe, Ryuichi Okamoto, Takashi Nagaishi. APL DOWNREGULATION IN T CELLS IN THE SETTING OF CHRONIC COLITIS. UEGW 2023 2023.10.15

  2. Hiromune Katsuda, Go Ito, Yui Hiraguri, Tomohiro Muto, Shun Ishido, Masanori Kobayashi, Hironari Yamashita, Akira Ito, Hiroaki Ono, Atsushi Kudo, Mamoru Watanabe, Minoru Tanabe, Ryuichi Okamoto. Analysis of gene expression to elucidate the pathogenesis of pancreatic solid pseudopapillary neoplasm.. UEGW2023 2023.10.14

  3. David B. Clemow, Christophe Sapin, Toshifumi Hibi, Marla C. Dubinsky, Severine Vermeire, Stefan Schreiber, Theresa Hunter Gibble, Laurent Peyrin-Biroulet, Mamoru Watanabe, Remo Panaccione. Association of Ulcerative Colitis Bowel Urgency Improvement With Clinical Response and Remission. UEGW 2022.10.09 Wien

  4. Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi , Go Ito, Yoshihito Kano, Tomohiro Mizutani, Hiromichi Shimizu , Mamoru Watanabe, Ryuichi Okamoto, Shiro Yui. Application of DSS-Grafting Assay to Evaluate the Potential of Cecum Organoids as a Useful Cellular Source for the Treatment of Colitis. DDW 2022.05.22 San Diego

  5. Mamoru Watanabe. Machine learning to synthesize endoscopy findings in ulcerative colitis. IOBD Satellite Meeting 2021.11.10 Bordeaux(France),Virtual

  6. Stefan Schreiber,Mamoru Watanabe 他. Safety analysis of filgotinib for ulcerative colitis: results from the phase 2b/3 SELECTION study and phase 3 SELECTIONLTE long-term extension study. UEGW2021 2021.10.04 ウィーン(オーストリア)、Virtual

  7. Mamoru Watanabe, Katsuyoshi Matsuoka, Toshihide Ohmori, Koichi Nakajima, Tetsuya Ishida ,Yoh Ishiguro, Kazunari Kanke, Kiyonori Kobayashi, Fumihito Hirai, Kenji Watanabe, Toshifumi Hibi. AJM300, an Oral Antagonist of α4-Integrin, as induction therapy for patients with Moderately Active Ulcerative Colitis: A Phase 3, randomized, double-blind, placebo-controlled induction study. ECCO2021 2021.07.10 Web開催

  8. Stefan Schreiber, Mamoru Watanabe, Chohee Yun, Yan Zhou, Jeremy Hsieh, Ulrik Moerch, Gerhard Rogler, Edward V Loftus Jr. Safety analysis of filgotinib for Ulcerative Colitis: results from the phase 2b/3 SELECTION study and phase 3 SELECTIONLTE long-term extension study. ECCO2021 2021.07.08 Web開催

  9. Laurent Peyrin-Biroulet, Edward V. Loftus Jr, Silvio Danese, Severine Vermeire, William J. Sandborn, Ronald Fogel6, Sandeep Nijhawan, Radoslaw Kempinski, Rafal Filip, Ihor Hospodarskyy, John McNally, Chohee Yun, Sally Zhao, Xiaopeng Liu, Chantal Tasset, Robin Besuyen, Mamoru Watanabe, Stefan Schreiber, Gerhard Rogler, Toshifumi Hibi, Brian G Feagan. Efficacy and Safety of Filgotinib as Maintenance Therapy for Patients with Moderately to Severely Active Ulcerative Colitis: Results from the Phase 2b/3 SELECTION Study. DDW2021 2021.05.23 Web開催

  10. Stefan Schreiber, Edward V Loftus Jr, Gerhard Rogler, Chohee Yun, Yan Zhou, Sally Zhao, Jeremy Hsieh, Ulrik Moerch, Mamoru Watanabe. Safety Analysis of Filgotinib for Ulcerative Colitis: Results from the Phase 2b/3 SELECTION Study and Phase 3 SELECTIONLTE Long-Term Extension Study. DDW2021 2021.05.21 Web開催

  11. Mamoru Watanabe. Clinical Application of Organoids for Tissue Regeneration.. KDDW2020 2020.11.20 オンライン

  12. Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Yudai Kojima, Michio Onizawa, Taro Watabe, Richard S. Blumberg, Mamoru Watanabe. BCR signaling in lymphoid tissues regulated by the long isoform of Ceacam1.. FOCIS2020 2020.10.28 Web開催

  13. Mamoru Watanabe. Organoid medicine in human GI diseases.. EMBO EMBL SYMPOSIUM 2020.10.22 オンライン

  14. Takashi Nagaishi, Daiki Yamada, Naoya Tsugawa, Taro Watabe, Eiko Saito, Masayoshi Fukuda, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe. A case of villous atrophy with CCR4+ T cell infiltration in the small intestine.. UEGW2020 2020.10.10 Web開催

  15. Fukiko Kawai-Kitahata, Yasuhiro Asahina , Sei Kakinuma, Miyako Murakawa, Sayuri Nitta, Masato Miyoshi, Ayako Sato, Jun Tsuchiya, Taro Shimizu, Eiko Takeichi, Mina Nakagawa, Yasuhiro Itsui, Seishin Azuma, Shinji Tanaka , Minoru Tanabe, Shinya Maekawa, Nobuyuki Enomoto and Mamoru Watanabe. Comprehensive analysis of cancer-related genes and aav/hepatitis b virus integration into genome on development of hepatocellular carcinoma in patients with prior hepatitis b virus infection. EASL The Digital International Liver Congress 2020 2020.08.28 Web開催

  16. Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Yudai Kojima, Richard S. Blumberg, Mamoru Watanabe. BCR signaling in lymphoid tissues is regulated by the long isoform of Ceacam1.. MICS2020 2020.07.20 Web開催

  17. Toshimitsu Fujii, Shuji Hibiya, Chiaki Maeyashiki, Eiko Saito, Kento Takenaka, Maiko Motobayashi, Hiromichi Shimizu, Masakazu Nagahori, Kazuo Ohtsuka, Masayuki Kurosaki, Tsunehito Yauchi, Mamoru Watanabe. Intolerance to 5-aminosalicylate is a risk of poor prognosis in Ulcerative colitis patients.. ECCO2020 2020.02.14 Vienna(Austria)

  18. Sakurako Kobayashi, Satoshi Watanabe, Yosuke Yoneyama, Kousuke Tanimoto, Ryu Nishimura, Sayaka Nagata, Masami Inoue, Kouhei Suzuki, Sei Kakinuma, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Takanori Takebe, Shiro Yui. Conceptual basis of lineage shift between intestinal epithelium and hepatocytes. Keystone Symposia, Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease 2020.01.22 Vancouver(Canada)

  19. Kento Takenaka, Kazuo Ohtsuka, Mamoru Watanabe. Small bowel endoscopic healing of Crohn’s disease treated with anti-TNF antibodies. JDDW2019 2019.11.21

  20. 藤井俊光、日比谷秀爾、齊藤詠子、竹中健人、清水寛路、長堀正和、大塚和朗、黒崎雅之、矢内常人、泉 並木、渡辺 守. 潰瘍性大腸炎における5ASA不耐は予後不良因子となる. 日本消化器病関連学会週間(JDDW)2019 2019.11.21 神戸コンベンションセンター(兵庫県神戸市)

  21. Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Sho Watanabe, Nobuhiro Katsukura, Tomoaki Shirasaki, Ryuichi Okamoto, Mamoru Watanabe. Establishment of chronic inflammation model using human small intestinal and colonic organoids. UEG Week 2019 2019.10.23 Fira Gran Via, Barcelona, Spain

  22. Mina Nakagawa, Kanako Noritake, Kumiko Yamaguchi, Janelle Moross, Jun Tsuruta, Keiichi Akita. Introduction of Clinical Exchange Training for Medical and Dental Students. AMEE 2019 2019.08.26 Vienna(Austria)

  23. Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Daiki Yamada, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe. Analysis of APL expression in an animal model of chronic colitis. FOCIS2019 2019.07.20 Boston Marriott Copley Place

  24. Daiki Yamada, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe. Analysis of Ileocecal Immune Response in an Animal Model of Colitis. ICMI 2019 2019.07.17 Brisbane Convention & Exhibition Centre(Brisbane)

  25. Kana Otsubo, Yoichi Nibe, Chiaki Maeyashiki, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Mamoru Watanabe, Shigeru Oshima. The role of ubiquitination in crosstalk of intestinal epithelial cell death and autophagic signaling was revealed by a novel polyubiquitin imaging system.. 19th International congress of mucosal immunology 2019.07.17 the Brisbane Convention & Exhibition Centre(Brisbane, Australia)

  26. Okamoto R, Watanabe M. 【Focus Session: Cutting Edge Regenerative Medicine Using Stem Cells】Intestinal Epithelial Stem Cell Organoids and IBD. ISSCR2019 2019.06.26 Los Angeles (USA)

  27. Shiro Yui, Mamoru Watanabe. Stem Cells in Gut, Who are They and How They Work, What Can We Count on Them. AOCC2019 2019.06.16 Taipei(Taiwan)

  28. Eiko Saito, Kohei Suzuki, Shuuji Hibiya, Maiko Motobayashi, Kento Takenaka, Nobukatsu Horita, Hiromichi Shimizu, Michio Onizawa, Toshimitsu Fujii, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. The clinical efficacy of ustekinumab (UST) in patients with Crohn’s disease (CD). AOCC2019 2019.06.15 台北

  29. Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Kohei Suzuki, Hiromichi Shimizu, Maiko Motobayashi, Shuji Hibiya, Eiko Saito, Masakazu Nagahori, Mamoru Watanabe. Small bowel endoscopic healing of Crohn’s disease treated with anti-TNF antibodies. The 7th Annual Meeting of Asian Organization for Crohn's and Colitis (AOCC 2019) 2019.06.15 台北

  30. Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Sho Watanabe, Nobuhiro Katsukura, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term inflammation model using human colonic organoids. The 7th annual meeting of AOCC 2019.06.15 Taipei, Taiwan

  31. Daiki Yamada, Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe. APL downregulation in an animal model of chronic colitis. AOCC2019 2019.06.15 Taipei Marriott Hotel

  32. Kawai M, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Yui S, Okamoto R, Watanabe M. Functional analysis of isoflavones using patient-derived intestinal organoids. AOCC2019 2019.06.14 Taipei(Taiwan)

  33. Ryuichi Okamoto, Mao Kawai, Minami Hama, Sayaka Nagata, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Sho Anzai, Junichi Takahashi, Reiko Kuno, Sayaka Takeoka, Yui Hiraguri, Shiro Yui, Mamoru Watanabe. 【The 6th JSGE International Topic Conference Lifestyle-related Diseases in Gastroenterology】Gastrointestinal tract(role of gut microbiome and diet). 第105回 日本消化器病学会総会 2019.05.10 ホテル日航金沢(石川県金沢市)

  34. Miyako Murakawa, Yasuhiro Asahina, Emi Inoue, Mina Nakagawa, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Tomoyuki Tsunoda, Fukiko Kawai-Kitahata, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Mamoru Watanabe. The association of serum IFN-lambda 3 levels with liver fibrosis and hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents. EASL, The International Liver Congress 2019 2019.04.13 Vienna (Austria)

  35. Mina Nakagawa, Yasuhiro Asahina, Jun Tsuchiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Emi Inoue, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Makoto Tomita, Mamoru Watanabe. Impact of HCV clearance on HCC development and patient survival: Propensity score-matched analysis of an ongoing database of 2173 CHC patients. EASL, The International Liver Congress 2019 2019.04.13 Vienna(Austria)

  36. Shun Kaneko, Masayuki Kurosaki, Nobuharu Tamaki, Jun Itakura, Sakura Kirino, Leona Osawa, Keiya Watakabe, Mao Okada, Wan Wang, Takao Shimizu, Mayu Higuchi, Kenta Takaura, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Takahashi, Namiki Izumi. Efficacy and safety of switching therapy from tenofovir disoproxil fumarate to tenofovir alafenamide for hepatitis B virus infection. EASL, The International Liver Congress 2019 2019.04.12 Vienna(Austria)

  37. Tsuchiya K, Watanabe S, Shirasaki T, Nishimura R, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M. TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation.. ECCO2019 2019.03.09 Copenhagen(Denmark)

  38. Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Oshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M. Synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein. ECCO2019 2019.03.08 Copenhagen(Denmark)

  39. Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Sho Watanabe, Nobuhiro Katsukura, Tetsuya Nakamura, Mamoru Watanabe. Establishment of an in vitro system to evaluate the therapeutic effect of the investigational drug on ulcerative colitis using human colonic organoids.. 14th Congress of ECCO 2019.03.08 Bella Center,Copenhagen, Denmark

  40. Takashi Nagaishi, Yudai Kojima, Daiki Yamada, Taro Watabe, Naoya Tsugawa, Nisha Jose, Michio Onizawa, Mamoru Watanabe.. APL expression is downregulated in an animal model of chronic colitis.. ECCO 2019 2019.03.08 Bella Center(Copenhagen)

  41. Suzuki K, Shimizu H, Kawai M, Takahashi J, Anzai S, Kawamoto A, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M . UC-related and segment-specific properties of patientderived colonic organoids. ECCO2019 2019.03.07 Copenhagen(Denmark)

  42. Shigeru Oshima, Yoichi Nibe, Akiko Tamura, Hiroki Matsuda, Emi Aonuma, Kana Otsubo, Mamoru Watanabe. K33-linked polyubiquitin is recruited by SQSTM1/p62. Keystone Symposia: Autophagy(B2) 2019.02.19 Eldorado Hotel &Spa(Santa Fe, New Mexico, USA )

  43. 齊藤詠子、秋山慎太郎、鈴木康平、本林麻衣子、竹中健人、清水寛路、鬼澤道夫、藤井俊光、長堀正和、大塚和朗、渡辺 守. クローン病における抗TNF-α抗体二次無効時のウステキヌマブの治療成績について. 第9回日本炎症性腸疾患学会学術集会 2018.11.22 メルパルク京都(京都府京都市)

  44. Asahina Y, Kawai-Kitahata F, Murakawa M, Nitta S, Nakagawa M, Kakinuma S, Watanabe M. Gene Mutational Profile and Viral Integration in Hepatocellular Carcinoma with or without HBV/HCV Suppression. AASLD, The Liver Meeting 2018 2018.11.10 San Francisco (USA)

  45. Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura. Mice overexpressing MKL1 in macrophages experience fulminant colitis. UEGW 2018 2018.10.22 Vienna(Austria)

  46. Yudai Kojima, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Nisha Jose, Daiki Yamada, Akinori Hosoya, Takahiro Adachi, Mamoru Watanabe. B cell-mediated ileocecal immune response is activated in the early phase of colitis development. UEGW 2018 2018.10.22 Vienna(Austria)

  47. Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Okamoto R, Nakamura T, Watanabe M. Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient. UEGW 2018 2018.10.22 Vienna(Austria)

  48. Ishibashi F, Kuwabara K, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Ectopic expression of reg3a in the mice distal Colon is mediated by interactions between notch and Il-22 signaling pathways, and promotes tissue repair By the augmentation of EGFR signaling. UEGW 2018 2018.10.22 Vienna(Austria)

  49. Kuwabara K, Ishibashi F, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Long-lived secretory cells residing in the mouse proximal colon serve as reserve stem cells under DNA damage-induced mucosal injury. UEGW 2018 2018.10.22 Vienna(Austria)

  50. Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Nishimura S, Katsukura N, Oshima S, Okamoto R, Tetsuya N, Watanabe M. Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation. UEGW 2018 2018.10.22 Vienna(Austria)

  51. Motoya S, Watanabe K, Ogata H, Kanai T, Matsui T, Suzuki Y, Shikamura M, Sugiura K, Oda K, Hori T, Araki T, Watanabe M, Hibi T. A phase 3 study of vedolizumab in Japanese patients with ulcerative colitis: effects on time to disease worsening and treatment failure. UEGW 2018 2018.10.22 Vienna(Austria)

  52. Okamoto R, Watanabe M.. Regenerative medicine for the treatment of inflammatory bowel disease. 5th TERMIS World Congress 2018 2018.09.07 Kyoto(JAPAN)

  53. Suzuki K, Takahashi J, Hiraguri Y, Yui S, Shimizu H, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M. . Crohn’s disease patient-derived small intestinal organoids reveal diseasestatus related modification of stem cell properties.. 5th TERMIS World Congress 2018 2018.09.07 Kyoto(JAPAN)

  54. Takenaka K, Ohtsuka K, Fujii T, Nagahori M, Saito E, Motobayashi M, Suzuki K, Watanabe M. Small bowel mucosal healing of Crohn’s disease treated with anti-TNF antibodies. FALKシンポジウム 2018.09.07 京都ホテルオークラ(京都府京都市)

  55. Suzuki K, Murano T, Hiraguri Y, Takahashi J, Shimizu H,Anzai S, Kuwabara K, Kawamoto A, Ishibashi F, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Watanabe M, Okamoto R... Crohn’s disease patient-derived small intestinal organoids reveal disease-status related modification of stem cell properties.. 5th TERMIS World Congress 2018 2018.09.06 Kyoto(JAPAN)

  56. Yuka Matsumoto, Mamoru Watanabe, Tetsuya Nakamura. Development of a new mouse model of short bowel syndrome that may allow for the assessment of therapeutic efficacy of heterotopic transplantation of small intestinal organoids. 5th TERMIS World Congress 2018.09.04 国立京都国際会館(京都府京都市)

  57. Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura. Overexpression of MKL1 in Macrophages leads to the development of murine colitis. MICS 2018 2018.07.19 Oxford(UK)

  58. Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura. Mice overexpressing MKL1 in macrophages are susceptible to DSS-induced colitis. FOCIS 2018 2018.06.22 San Francisco (USA)

  59. Saito E, Suzuki K, Shimizu H, Motobayashi M, Takenaka K, Onizawa M, Fujii T, Nagahori M, Ohtsuka K, Watanabe M. The clinical efficacy of switching cases between Infliximab(IFX) andAdalimumab(ADA) in patients with ulcerative colitis. AOCC2018 2018.06.22 Shanghai

  60. Takashi Nagaishi, Taro Watabe, Tsugawa, Yudai Kojima, Nisha Jose, Daiki Yamada, Takahiro Adachi, Mamoru Watanabe. Analysis of cecal immune response in a murine model of colitis using intravital imaging. FOCIS 2018 2018.06.20 San Francisco (USA)

  61. Ishibashi F, Shimizu H, Kawamoto A, Suzuki K, Anzai S, Kuwabara K, Takahashi J, Nagata S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Mouse colonic secretory cells de-differentiate into intestinal stem cells and promote mucosal repair through activation of NF-KB signalin. ISSCR2018 2018.06.20 Melbourne(Australia)

  62. Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura. Mice overexpressing MKL1 in macrophages are susceptible to the development of colitis. DDW 2018 2018.06.05 Washington D.C (USA)

  63. Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Takahiro Adachi, Mamoru Watanabe. Analysis of ileocecal immune response in an animal model of colitis using intra-vital imaging. DDW 2018 2018.06.05 Washington D.C (USA)

  64. Shirasaki T, Tsuchiya K, Nishimura R, Watanabe S, Hibiya S, Katsukura N, Okamoto R, Nakamura T, Watanabe M.. Identification of lesion-specific epithelial function of ulcerative colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.. DDW2018 2018.06.05

  65. Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.. Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis.. DDW2018 2018.06.05 Washington D.C (USA)

  66. Suzuki K, Kuwabara K, Takahashi J, Anzai S, Kuno R, Kawamoto A, Ishibashi F, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M.. Single-cell level analysis of organoids derived from CD patients reveals disease-status related modifications of small intestinal stem cells. DDW2018 2018.06.04 Washington D.C (USA)

  67. Ohtsuka K, Takenaka K, Suzuki K, Fujii T, Nagahori M, Matsuoka K, Saito E, Katsukura N, Fukuda M, Araki A, Watanabe M. Usefulness of single-balloon enteroscopy: from a single center 990 experiences. DDW2018 2018.06.03 Washington D.C (USA)

  68. C. Maeyashiki, H. Melhem, K. Baebler, S. Lang, M. Scharl, G. Rogler, C. de Valliere. Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress and Autophagy in an Intestinal Epithelial Cell Model. DDW2018 2018.06.02 Washington D.C (USA)

  69. Shiro Yui, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Fetalization of colonic epithelium medicated by YAP/TAZ links ECM remodeling to tissue regeneration. GI Research Academy 2018 2018.05.25 Keidanren Kaikan、Tokyo, Japan

  70. Kitahata-kawai F, Asahina Y, KakinumaS, Murakawa M, Nitta S, Nagata H, Kaneko S, Inoue E, Miyoshi M, Tsunoda T, Sato A, Nakagawa M, Itsui Y, Azuma S, Tanaka S, Tanabe M, Maekawa S, Enomoto N and Watanabe M. Difference of gene mutational profile among viral- and non-viral HCC with or without prior HBV infection: Results of comprehensive deep sequencing analyses of cancer genes and HBV/A AV integration. EASL, The International Liver Congress 2018 2018.04.14 Paris(France)

  71. Watanabe M. Organoids as a therapy resource from clinical trail in a dish to engraftment. Internarional Cluster Symposium 2018 2018.03.22 Hamburg(Germany)

  72. Kano Y. Tyrosyl phosphorylation of KRAS disrupts the GTPase cycle and inhibits pancreatic cancer cell growth. Pizza Talk of Department of Biochemistry 2018.03.21 Toronto(Canada)

  73. Nishimura R, Tsuchiya K, Shirasaki T, Watanabe S, Hibiya S, Okamoto R, Nakamura T, Watanabe M.. The identification of lesion-specific gene expression in intestinal epithelial cells of Ulcerative Colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.. The 13th Congress of ECCO 2018.02.16 Vienna

  74. Shuji Hibiya, Kiichiro Tsuchiya, Sho Watanabe, Ryu Nishimura, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura ,Mamoru Watanabe. Establishment of in vitro human model for Ulcerative Colitis by using human colon organoid culture. 13th Congress of ECCO 2018.02.16 Vienna(Austria)

  75. Matsuda H, Nibe Y, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M, Oshima S. K33-linked polyubiquitin is recruited by SQSTM1/p62.. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  76. Otsubo K, Maeyashiki C, Aonuma E, Matsuda H, Nibe Y, Kobayashi M, Matsuzawa Y, Watanabe M, Oshima S. Long-chain fatty acid regulates autophagy and polyubiquitination in intestinal epithelial cells. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  77. Nibe Y, Matsuda H, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M, Oshima S. Novel polyubiquitin imaging system, PolyUb-FC, visualized atypical polyubiquitin chain in living cells. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  78. Aonuma E, Nibe Y, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Watanabe M, Oshima S. Necroptosis stimulation regulates SQSTM1/p62-LC3 complex formation and polyubiquitination. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.29 Tahoe(USA)

  79. Tsugawa N, Nagaishi T, Watabe T, Hosoya A, Jose N, Kojima Y, Yoshikawa S, Karasuyama H, Adachi T, Watanabe M. Verification of immunoglobulin A regulation of mucosal microflora and homeostasis. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Miyagi (Japan)

  80. Watanabe M. 【Clinical Seminar】Chair. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Miyagi (Japan)

  81. Watabe T, Nagaishi T, Hosoya A, Jose N, Tsugawa N, Kojima Y, Yoshikawa S, Karasuyama H, Adachi T, Watanabe M . Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Miyagi (Japan)

  82. Watanabe M. 【Symposium 3:Tissue-specific immune diseases】Chair. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Miyagi (Japan)

  83. Watanabe M. Stem Cell Therapy for IBD: Promise and Challenge. GZDDW2017 2017.11.11 (China)

  84. T. Fujii Y. Kitazume K. Takenaka M. Kimura E. Saito K. Matsuoka M. Nagahori K. Ohtsuka M. Watanabe. Simplified MR enterocolonography Classification Based on Endoscopic Findings for Activity Assessment of Crohn’s Disease. UEGW2017 (欧州消化器病学会週間2017) 2017.11.01 Barcelona(Spain)

  85. A. Kawamoto G. Ito T. Nakata S. Fujii K. Suzuki F. Ishibashi H. Shimizu S. Nagata S. Anzai R. Kuno K. Kuwabara M. Kawai J. Takahashi M. Hama K. Tsuchiya T. Nakamura R. Okamoto M. Watanabe. The ubiquitin-like protein ubiquitin d is up-regulated by synergy of notch and pro-inflammatory cytokines in the inflamed intestinal epithelia of ibd patients.. UEGW2017 (欧州消化器病学会週間2017) 2017.11.01 Barcelona(Spain)

  86. S. Watanabe K. Tsuchiya T. Shirasaki S. Hibiya S. Ooshima T. Nakamura R. Nishimura R. Okamoto M. Watanabe. TP53 mutation acquires higher malignant potential in human colon cancer cells. UEGW2017 (欧州消化器病学会週間2017) 2017.11.01 Barcelona(Spain)

  87. F. Ishibashi H. Shimizu A. Kawamoto G. Ito T. Nakata S. Fujii K. Suzuki R. Kuno S. Anzai K. Kuwabara M. Kawai J. Takahashi M. Hama S. Nagata K. Tsuchiya T. Nakamura R. Okamoto M. Watanabe. Reprogrammed Atoh1+ intestinal epithelial cells contribute to regenerate damaged colonic mucosa in DSS-induced colitis. UEGW2017 (欧州消化器病学会週間2017) 2017.11.01 Barcelona(Spain)

  88. N. Tsugawa T. Nagaishi T. Watabe N. Jose A. Hosoya Y. Kojima T. Adachi R. Blumberg M. Watanabe. Verification of immunoglobulin a regulation of microflora and protection of intestinal mucosa. UEGW2017 (欧州消化器病学会週間2017) 2017.10.31 Barcelona(Spain)

  89. Takenaka K, Ohtsuka K, Kitazume Y, Fujii T, Matsuoka K, Kimura M, Nagahori M, Watanabe M. Utility of Magnetic Resonance Evaluation for Small Bowel Endoscopic Healing in Patients with Crohn’s Disease. UEGW2017 (欧州消化器病学会週間2017) 2017.10.30 Barcelona(Spain)

  90. Shun Kaneko, Sei Kakinuma, Yasuhiro Asahina, Akihide Kamiya, Masato Miyoshi, Tomoyuki Tsunoda, Emi Inoue-Shinomiya, Sayuri Nitta, Ayako Sato, Yu Asano, Hiroko Nagata, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Mamoru Watanabe. A novel culture model for coinfection of hepatitis B and hepatitis C viruses using human induced pluripotent stem cell–derived hepatic cells for analyses of changes in host-innate immune responses . AASLD The Liver Meeting 2017 2017.10.22 Washington DC

  91. Nakagawa M, Asahina Y, Nagata H, Kaneko S, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Azuma S, Kakinuma S, Tanaka Y, Watanabe M. Evaluation of an early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C patients treated with All-Oral DAAs - propensity score-matched analysis of a prospective database -. AASLD, The Liver Meeting 2017 2017.10.22 Washington D.C (USA)

  92. Nitta S, Murakawa M, Kato T, Sato A, Tsunoda T, Miyoshi M, Asano Y, Kaneko S, Nagata H, Kawai-Kitahata F, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Asahina Y. The analysis of NS5A Resistance-Associated Substitutions (RAS): In vitro study of NS5A recombinant hepatitis C in infectious cell culture system for various RAS detected after treatment failure in chronic hepatitis C patients. AASLD The Liver Meeting 2017 2017.10.21 Washington D.C (USA)

  93. Murakawa M, Asahina Y, Nakagawa M, Nitta S, Kawai-Kitahata F, Nagata H, Kaneko S, Asano Y, Miyoshi M, Tsunoda T, Inoue-Shinomiya E, Sato A, Itsui Y, Kakinuma S, Azuma S, Watanabe M. On-treatment higher levels of alpha-fetoprotein and M2BPGi are associated with development of hepatocellular carcinoma during nucleos(t)ide analog therapy in patients with HBV chronic infection. AASLD, The Liver Meeting 2017 2017.10.21 Washington DC (USA)

  94. 日比谷秀爾、土屋輝一郎、渡辺 守. 長期炎症環境によるWnt非依存性不死化大腸オルガノイドの樹立. 第76回日本癌学会学術集会 2017.09.29 パシフィコ横浜(神奈川県横浜市)

  95. YOHEI FURUMOTO, AKIHIRO ARAKI, SAYURI NITTA, HIROKO NAGATA, KENTO TAKENAKA, KOUHEI SUZUKI, ERIKO OKADA, TAKAO HORIUCHI, MAMORU WATANABE. Report of successful rescue of disrupted capsafter rule endoscopy retention. Asian Pacific Digestive Week 2017.09.26 Hongkong

  96. Seishin Azuma, Yasuhiro Asahina, Sei Kakinuma, Keiko Azuma, Mamoru Watanabe. Diabetic retinopathy as a risk factor associated with development of hepatocellular carcinoma in non-alcoholic fatty liver disease. Asian Pacific Digestive Week 2017 2017.09.25 香港

  97. Watanabe M. 【Inflammatory Bowel Disease:Future Treatment Paradigm】Chair. APDW2017 2017.09.25 (Hong Kong)

  98. Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Fujii T, Nagahori M, Kimura M, Watanabe M.. Magnetic resonance enterography for small bowel mucosal healing in patients with Crohn’s disease.. APDW2017 2017.09.23 Hong Kong Convention and Exhibition Centre(香港)

  99. Horita N, Gifford GB, Lafkas D, Siebel CW, Samuelson LC.. NOTCH ligand Jagged1 regulates epithelial cell proliferation in mouse gastric corpus. 2017 FASEB Science Research Conference, GASTROINTESTINAL TRACT XVII: CURRENT BIOLOGY OF THE GI TRACT, MUCOSA, MICROBIOTA, AND BEYOND 2017.07.31 The Steamboat Grand

  100. Nagaishi T, Watabe T, Jose N, Hosoya A, Kojima Y, Tsugawa N, Adachi T, Watanabe M. Deficiency of IgA Induces Microflora Alteration and Ileal Inflammation. ICMI 2017 2017.07.21 Washington DC (USA)

  101. Motobayashi M, Matsuoka K, Iwamoto F, Takenaka K, Fujii T, Nagahori M, Enomoto N, Ohtsuka K, Watanabe M. Correlation of Fecal Calprotectin Levels with Endoscopic Severity Evaluated with Balloon-assisted Endoscopy in Patients with Crohn’s Disease. . AOCC2017 2017.06.17 Seoul, Korea

  102. Watanabe M. Being at the leading Edge in IBD Care and Research:Chair . AOCC2017 2017.06.17 Seoul (Korea)

  103. Okamoto R, Watanabe M. Stem cell-based therapies: Ready for clinical practise? . AOCC2017 2017.06.16 Seoul, Korea

  104. Hosoya A, Nagaishi T, Watabe T, Tsugawa N, Jose N, Kojima Y, Adachi T, Watanabe M. Verification of immunoglobulin A protection of intestinal mucosa from microflora. AOCC2017 2017.06.16 Seoul (Korea)

  105. Matsuoka K, Watanabe M. Recent pivotal studies for IBD in Asians: current status and future directions. AOCC2017 2017.06.16 Seoul, Korea

  106. Kawamoto A, Ito G, Nakata T, Fujii S, Suzuki K, Ishibashi F, Shimizu H, Tsuchiya K, Nakamura T, Okamoto R, Watanabe M. Synergy of Notch signaling and pro-inflammatory cytokines leads to up-regulation of UBD in the inflamed intestinal epithelia of IBD patients. The 5th Annual Meeting of Asian Organization for Crohn's and Colitis 2017.06.16 Seoul, Korea

  107. Fujii T, Kitazume Y, Takenaka K, Kimura M, Matsuoka K, Nagahori M, Ohtsuka K, Watanabe M. The 5-point MR enterocolonography classification based on endoscopic findings for activity assessment of Crohn's disease. AOCC2017 2017.06.16 Seoul, Korea

  108. Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Katsuyoshi Matsuoka, Toshimitsu Fujii, Masakazu Nagahori, Maiko Kimura, Mamoru Watanabe. Magnetic resonance evaluation for small bowel endoscopic remission in patients with crohn’s disease.. AOCC2017 2017.06.15 Seoul, Korea

  109. Nagaishi T, Watabe T, Jose N, Hosoya A, Kojima Y, Tsugawa N, Adachi T, Watanabe M. IgA Deficiency Induces Spontaneous Inflammation in the Ileum. FOCIS 2017 2017.06.14 Chicago (USA)

  110. Nibe Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashia M, Matsuzawa Y , Nakada S, Watanabe M. Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy.. GI research Academy 2017 2017.06.09 経団連会館(東京都千代田区)

  111. Yoichi Nibe, Shigeru Oshima, Emi Aonuma, Hiroki Matsuda, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Shinichiro Nakada, Mamoru Watanabe. Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy via p62.. The 8th International Symposium on Autophagy 2017.05.29 Nara Kasugano International Forum 甍 IRAKA(Japan)

  112. Kana Otsubo, Shigeru Oshima, Chiaki Maeyashiki, Emi Aonuma, Hiroki Matsuda, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Mamoru Watanabe. HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. The 8th International Symposium on Autophagy 2017.05.29 Nara Kasugano International Forum 甍 IRAKA(Japan)

  113. Watanabe M. Recent Advances in Therapy of IBD. 2017 TSIBD Spring Forum 2017.05.27 Taipei

  114. Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Watanabe M. The Ubiquitin Hybrid Gene UBA52 Regulates Cell Cycle and Ubiquitination of Ribosome in Colon Cancer. DDW 2017 2017.05.09 Chicago (USA)

  115. Watabe T, Nagaishi T, Hosoya A, Jose N, Tokai A, Kojima Y, Adachi T, Watanabe M. The lack of secreted IgA spontaneously induces the mucosal inflammation specifically in the ileum. DDW 2017 2017.05.09 Chicago (USA)

  116. Ishibashi F, Shimizu H, Nakata T, Fujii S, Suzuki K, Kawamoto A, Anzai S, Kuno R, Nagata S, Ito G, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Okamoto R, Watanabe M. Lineage tracing reveals contribution of atoh1+ cell-derived stem cells in the homeostasis, repair, and carcinogenesis of the intestinal epithelium. DDW2017 2017.05.09 Chicago(USA)

  117. Kawai-Kitahata F, Asahina Y, Kakinuma S, Murakawa M, Niita S, Nagata H, Kaneko S, Otani S, Miyoshi M, Tsunoda T, Sato A, Nakagawa M, Itsui Y, Azuma S, Tanaka S, Tanabe M, Maekawa S, Enomoto N, Watanabe M. Genetic differences in hepatocellular carcinoma among chronic persistent hepatitis B virus infection with or without viral suppression and prior hepatitis B virus infection. EASL The International Liver Congress 2017 2017.04.20 Amsterdam (Netherlands)

  118. Watanabe M. Intestinal Epithelial Stem Cells for the Treatment of GI Disease. Digestive and Liver Diseases Conference, Specaial Lecture 2017.04.05 Dallas(USA)

  119. Kawamoto A, Nakata T, Fujii S, Suzuki K, Ishibashi F, Shimizu H, Tsuchiya K, Nakamura T, Okamoto R, Watanabe M. Notch signaling and TNF-α synergistically up-regulate stem cell-specific genes, OLFM4 and UBD, in the inflamed intestinal epithelia of IBD patients. 2016 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation of America's Clinical & Research Conference (CCFA) 2016.12.10 Orlando, Florida

  120. Watanabe M. Inflammation-related Carcinogenesis in Intestine.. 2016 TMDU-TMU Joint Symposium 2016.11.12 Taipei Medical University,Taipei(China)

  121. Shun Kaneko, Sei Kakinuma, Yasuhiro Asahina, Akihide Kamiya,Masato Miyoshi, Tomoyuki Tsunoda, Sayuri Nitta, Ayako Sato, Yu Asano, Hiroko Nagata, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Mamoru Watanabe. Genetically modified human induced pluripotent stem cell-derived hepatic progenitor-like cell lines as a model for interaction between hepatitis B virus and host cells. AASLD The Liver meeting 2016 2016.11.11 Boston(USA)

  122. Watanabe M. 【IBD Consensus Symposium:Asia Pacific Consensus on IBD Management】Chair. APDW2016 2016.11.05 Kobe convention center, KOBE(JAPAN)

  123. Takenaka K, Ohtsuka K, Watanabe M. Magnetic resonance evaluation for small bowel strictures of Crohn’s disease: comparison with balloon enteroscopy. APDW2016 2016.11.05 Kobe convention center, KOBE(JAPAN)

  124. Watabe T, Nagaishi T, Tokai A, Jose N, Hosoya A, Kojima Y, Yamazaki M, Richard S. Blumberg, Watanabe M. CD66a regulation of BCR signaling in the activated B cells . APDW 2016 2016.11.04 Kobe Cinvention Center(Kobe JAPAN)

  125. Watanabe M. 【Innovative Topics-L5】Chair. APDW2016 2016.11.03 Kobe convention center, KOBE(JAPAN)

  126. Watanabe M. 【Hands-on Seminar:Clinical Science】Chair. APDW2016 2016.11.03 Kobe convention center, KOBE(JAPAN)

  127. Tsuchiya K, Hibiya S, Fukushima K, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Atoh1 protein stabilization in colon tumor acquires the morphological change to signet ring cell carcinoma with cancer stem cell enrichment. APDW2016 2016.11.03 Kobe convention center, KOBE(JAPAN)

  128. Fujii T, Takenaka K, Kitazume Y, Kimura M, Matsuoka K, Nagahori M, Ohtsuka K, Watanabe M. MR enterocolonography can detect small bowel strictures and predict surgery in patients with Crohn’s disease: Comparison with balloon enteroscopy. APDW2016 2016.11.03 Kobe convention center, KOBE(JAPAN)

  129. Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Kojima Y, Watanabe M. Type 2 TNF receptor signaling in colonic epithelia may be involved in the development of colitis-associated carcinogenesis. APDW 2016 2016.11.03 Kobe Cinvention Center(Kobe JAPAN)

  130. Hosoya A, Nagaishi T, Tokai A, Watabe T, Jose N, Kojima Y, Yamazaki M, Richard S. Blumberg, Watanabe M. CEACAM1 regulation of BCR signaling in the activated B cells. UEGW2016 2016.10.19 VIENNA

  131. Hibiya S, Tsuchiya K, Watanabe S, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Construction of in vitro model of ulcerative colitis using mouse primary colonic organoid. UEGW2016 2016.10.18 Vienna(Austria)

  132. Toshimitsu Fujii, Kento Takenaka, Maiko Kimura, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. MR enterocolonography evaluation for small bowel strictures in patients with Crohn’s disease: comparison with balloon enteroscopy. UEGW2016 2016.10.18 Vienna(Austria)

  133. Watanabe M. Gut Microbiota, Epithelial Cells and Stem Cell Therapy in GI disease. Microbiome Science Days 2016.10.07 Germany

  134. Watanabe M. Intestinal Epithelial Stem Cells for the Treatment of Colitis.. eMed Meeting 2016 2016.10.04 Germany

  135. Watanabe M. Stem Cell Replacement in Gut. FNM2016 2016.08.26 San Francisco(USA)

  136. Nagaishi T, Tokai A, Watabe T, Jose N, Hosoya A, Yamazaki M, Blumberg RS, Watanabe M. BCR signaling in the activated B cells may be regulated by CEACAM1. Mucosal Immunology Course & Symposium (MICS)2016 2016.07.29 Toronto(Canada)

  137. Masakazu Nagahori. Anal fistula - Seton first or anti-TNF first : anti-TNF first. AOCC2016 2016.07.09 Kyoto International Conference Center, Kyoto(JAPAN)

  138. Kazuo Ohtsuka, Kento Takenaka, Toshimitsu Fujii, Katsuyoshi Matsuoka, Masakazu Nagahori, Maiko Kimura, Masayoshi Fukuda, Nobuhiro Katsukura, Mamoru Watanabe. Mucosal healing improves prognosis of endoscopic balloon dilatation for small intestinal strictures of Crohn’s disease. AOCC2016 2016.07.09 Kyoto International Conference Center, Kyoto(JAPAN)

  139. Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Atoh1 protein stabilization in colon tumor acquires the phenotype of signet ring cell carcinoma with cancer stem cell enrichment.. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto(JAPAN)

  140. Katsuyoshi Matsuoka, Naoki Yoshimura, Mamoru Watanabe, Satoshi Motoya, Keiichi Tominaga, Ryuichi Iwakiri, Kenji Watanabe, Toshifumi Hibi, For the AJM300 Study Group. AJM300, an oral α4 integrin antagonist, as induction therapy for active ulcerative colitis: a randomized trial. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto(JAPAN)

  141. Toshimitsu Fujii, Kento Takenaka, Maiko Kimura, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. The evaluation for small bowel strictures on MR enterocolonography in patients with Crohn’s disease. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto(JAPAN)

  142. Taro Watabe, Takashi Nagaishi, Arisa Tokai, Akinori Hosoya, Nisha Jose, Yudai Kojima, Motomi Yamazaki, Richard S. Blumberg, Mamoru Watanabe. BCR signaling in the activated B cells may be regulated by CD66a. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto(JAPAN)

  143. Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Mouse colonic organoid acquires wnt-independent survival property after long-term inflammation. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto(JAPAN)

  144. Toshifumi Hibi, Satoshi Motoya, Kori Wallace, Andreas Lazar, Yasuko Nishimura, Morio Ozawa, Roopal Thakkar, Anne M. Robinson, Mamoru Watanabe. Adalimumab 80 mg Every Other Week in Japanese Patients with Crohn’s Disease Who Lost Response to Maintenance Therapy. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto(JAPAN)

  145. Minami Hama, Ayumi Hayashi, Tomohiro Mizutani, Satoru Fujii, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ken Watanabe, Norio Shimizu, Ryuichi Okamoto, Mamoru Watanabe. Prevalence of viral DNA in the mucosal tissue and cultured organoids of inflammatory bowel disease patients. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto(JAPAN)

  146. Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Masakazu Nagahori, Katsuyoshi Matsuoka, Toshimitsu Fujii, Maiko Kimura, Tomoyuki Fujioka, Mamoru Watanabe. Enteroscopic and MR findings of small bowel in Crohn’s disease. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto(JAPAN)

  147. Maiko Kimura, Katsuyoshi Matsuoka, Eiko Saito, Toshimitsu Fujii, Kento Takenaka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. Salvage therapy for corticosteroid-refractory ulcerative colitis patients. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto(JAPAN)

  148. Ami Kawamoto, Go Ito, Toru Nakata, Satoru Fujii, Kohei Suzuki, Fumiaki Ishibashi, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Mamoru Watanabe. OLFM4 and UBD are up-regulated in the inflamed intestinal epithelia of IBD patients by synergy of Notch signaling and TNF-α. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto(JAPAN)

  149. Tomoaki Shirasaki, Kiichiro Tsuchiya, Shuji Hibiya, Ryu Nishimura, Keita Fukushima, Sho Watanabe, Ryuichi Okamoto, Tetsuya Nakamura and Mamoru Watanabe. Stimulation with the ligands of Toll like receptors in primary human organoids. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto(JAPAN)

  150. Meng-Tzu Weng, Katsuyoshi Matsuoka, Mamoru Watanabe, JY Lee, Sang Hyoung Park, Suk-Kyun Yang, Shu-Chen Wei. Thromboembolic events associated with inflammatory bowel disease in Asia: incidence and possible risk factors analysis. AOCC2016 2016.07.07 Kyoto International Conference Center, Kyoto(JAPAN)

  151. Tokai A, Nagaishi T, Watabe T, Jose N, Hosoya A, Yamazaki M, Onizawa M, Richard S. Blumberg, Watanabe M . Activated B cell receptor signaling may be regulated by CEACAM1. FOCIS 2016 2016.06.23 Boston

  152. Masanori Kobayashi, Shigeru Oshima, Yoishi Nibe, Chiaki Maeyashiki, Mamoru Watanabe. UBA52, ubiquitin hybrid ribisomal protein, regulates NF-κB signaling in colon cancer. DDW2016 2016.05.24 San Diego(USA)

  153. Takayuki Matsumoto, Satoshi Motoya, Kenji Watanabe, Tadakazu Hisamatsu, Hiroshi Nakase, Naoki Yochimura, Tetsuya Ishida, Shingo Kato, Tomoo Nakagawa, Motohiro Esaki, Masakazu Nagahori, Toshiyuki Matsui, Yuji Naito, Takanori Kanai, Yasuo Suzuki, Masanori Nojima, Mamoru Watanabe, Toshifumi Hibi. Comparison of abalimumab monotherapy and a combination with azathioprone for patients with crogn's disease:A prospective, multicenter, open-labeled clinical trial (DIAMOND Study). DDW2016 2016.05.24 San Diego(USA)

  154. Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe. In Vitro organoid model reveals PGF2 as a Robust Mediator of chloride & water secretion bt human intestinal epithelial cells. DDW2016 2016.05.23 San Diego(USA)

  155. Chiaki Maeyashiki, Shigeru Oshima, Yoishi Nibe, Masanori Kobayashi, Mamoru Watanabe. Indentification of autophagic regulators as therapeutic targets in intestinal epithelial cells. DDW2016 2016.05.23 San Diego(USA)

  156. Kazuo Ohtsuka, Kento Takenaka, Toshimitsu Fujii, Katsuyoshi Matsuoka, Masakazu Nagahori, Kengo Nozaki, Masayoshi Fukuda, Mamoru Watanabe. Mucosal Healing is imoietant for better outcomes of endosdopic balloon dilatation for smakk intestinal stricture of crohn's disease. DDW2016 2016.05.23 San Diego(USA)

  157. Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Tomoaki Shirasaki, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. ATOH1 Protein stabillzation in tumor acquires the morphological change to signet ring cell enrichment in colon cancer. DDW2016 2016.05.22 San Diego(USA)

  158. Toru Nakata, Go Ito, Hiromichi Shimizu, Satoru Fujii, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Ryuichi Okamoto, Mamoru Watanabe. Jagged1 is indispensable for the maintenance of tumor stem cell niche in APC-Deficient intestinal adenomas. DDW2016 2016.05.22 San Diego(USA)

  159. Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Construction of in vitro model for inflammatory bowel disease using primary colonic organoid. DDW2016 2016.05.21 San Diego(USA)

  160. Taichi Matsumoto, Wakana Mochizuki, Yoichi Nibe, Shintaro Akiyama, Yuka Matsumoto, Kengo Nozaki, Tomohiro Mizutani, Shigeru Ochima, Mamotu Watanabe, Tetsuya Nakamura. Rethinol stimulates proliferation of epithelial stem cells of the proximal colon through a retinoic acid-indeoendent mechanism. DDW2016 2016.05.21 San Diego(USA)

  161. Takashi Nagaishi, Arisa Tokai, Taro Watabe, Nisha Jose, Akinori Hosoya, Motomi Yamazaki, Richard S.Blumberg, Mamoru Watanabe. CEACAM1 may resulate BCR signaling in the activated B cells. DDW2016 2016.05.21 San Diego(USA)

  162. Kohei Suzuki, Satoru Fujii, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Go Ito, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Otsuka, Ryuichi Okamoto, Mamoru Watanabe. Single-cell level analysis reveals hoterogeneous expression of stem-cell specific genes in human small intestinal organoids. DDW2016 2016.05.21 San Diego(USA)

  163. Taku Kobayashi, Yasuo Suzuki, Satoshi Motoya, Fumihito Hirai, Haruhiko Ogata, Hiroaki Ito, Noriko Sato, Kunihiko Ozaki, Mamoru Watanabe, Toshifumi Hibi. Factors Associated With the First Trough Level of Infliximab at Week 2 That Predicts Short- and Long-Term Outcomes in Ulcerative Colitis. DDW2016 2016.05.21 San Diego(USA)

  164. Emma Calabrese, Torsten Kucharzik, Christian Maaser, Giovanni Maconi, Deike Strobel, Stephanie Wilson, Francesca Zorzi, Kerri L. Novak, David H. Bruining, Marietta Iacucci, Mamoru Watanabe, Elisabetta Lolli, Carlo Chiaramonte, Stephen B. Hanauer, Remo Panaccione, Francesco Pallone, Subrata Ghosh. Inter-Observer Agreement in Bowel Ultrasonography for Diagnostic Assessment in Patients With Crohn's Disease. DDW2016 2016.05.21 San Diego(USA)

  165. Kano Y, Jen Jen Yeh, Zhong-Yin Zhang, Ohh M. Novel treatment strategy for pancreatic cancer by targeting the ‘undruggable’ Ras oncoprotein. AACR Special Conference on Pancreatic Cancer 2016.05.14 Orlando(USA)

  166. Mamoru Watanabe. Closing Remarks. The 102nd JSGE-The 5th International Forum 2016.04.22 Tokyo(JAPAN)

  167. Kazuo Ohtsuka, Kento Takenaka, Mamoru Watanabe. 【Session 3: Imaging for follow up of IBD】Assessment of small intestinal lesions of Crohn’s disease. The 102nd JSGE-The 5th International Forum 2016.04.21 Tokyo(JAPAN)

  168. Kentaro Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Masakazu Nagahori, Katsuyoshi Matsuoka, Toshimitsu Fujii, Maiko Kimura, Tomoyuki Fujioka Mamoru Watanabe. Magnetic resonance evaluation for deep small intestinal strictures in patients with Crohn’s disease. The 102nd JSGE-The 5th International Forum 2016.04.21 Tokyo(JAPAN)

  169. Masanori Kobayashi, Shigeru Oshima, Yoishi Nibe, Chiaki Maeyashiki, Mamoru Watanabe. UBA52, ubiquitin hybrid protein, regulates NF κB signaling. The 102nd JSGE-The 5th International Forum 2016.04.21 Tokyo(JAPAN)

  170. Ryuichi Okamoto, Mamoru Watanabe. 【Session 4: Novel therapeutic approaches and emerging issues in IBD】Application of regenerative medicine for the treatment of inflammatory bowel disease. The 102nd JSGE-The 5th International Forum 2016.04.21 Tokyo(JAPAN)

  171. Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Matsuoka K, Fujii T, Kimura M, Fujioka T, Watanabe M. Enteroscopic and MR findings of small intestine in Crohn’s disease. The 7th APTC 2016.04.20 Tokyo(JAPAN)

  172. Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Nitta S, Tsunoda T, Miyoshi M, Asano Y, Nagata H , Goto F., Otani S, Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Watanabe M. A new model for studying interaction between hepatitis B virus and host cells derived from human induced pluripotent stem cells. EASL The International Liver Congress 2016 2016.04.14 Barcelona(Spain)

  173. Watanabe M. Gut Microbiota, Epithelial Cells and Stem Cell Therapy in IBD. AGA/CSG IBD Symposium 2016.04.08 Baijing(China)

  174. Kobayashi T, Suzuki Y, Motoya S, Hirai F, Ogata H, Ito H, Sato N, Ozaki K, Watanabe M, Hibi T. Factors associated with the first trough level of infliximab at week 2 that predicts short- and long-term outcomes in Ulcerative Colitis. 11th Congress of ECCO - European Crohn‘s and Colitis Organisation 2016.03.19 Amsterdam(Nederland)

  175. Matsuoka K, Saito E, Fujii T, Takenaka K, Iwamoto F, Kimura M, Nagahori M, Ohtsuka K, Watanabe M. Efficacy and safety of sequential rescue therapy with infliximab and tacrolimus in patients with corticosteroid-refractory Ulcerative Colitis. 11th Congress of ECCO - European Crohn‘s and Colitis Organisation 2016.03.19 Amsterdam(Nederland)

  176. Matsumoto T, Motoya S, Watanabe K, Hisamatsu T, Nakase H, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T. Comparison of adalimumab monotherapy and a combination with azathioprine for patients with Crohn’s Disease: A prospective, multicentre, open-labeled clinical trial (DIAMOND Study). 11th Congress of ECCO - European Crohn‘s and Colitis Organisation 2016.03.18 Amsterdam(Nederland)

  177. Nakagawa M. 【HCV 11】Chair. The 25th Asian Pacific Association for the Study of the Liver 2016.02.23 International Convention Center Pamir, Tokyo(JAPAN)

  178. Nakagawa M. 【HCV 12】Chair. The 25th Asian Pacific Association for the Study of the Liver 2016.02.23 International Convention Center Pamir, Tokyo(JAPAN)

  179. Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Nitta S, Tsunoda T, Miyoshi M, Asano Y, Nagata H, Goto F, Otani S, Kitahata F, Murakawa M , Itsui Y, Nakagawa M, Azuma S, Watanabe M. A Model for Interaction between HBV and Host Cells Derived from Human Induced Pluripotent Stem Cells. The 25th Asian Pacific Association for the Study of the Liver 2016.02.22 International Convention Center Pamir, Tokyo(JAPAN)

  180. Nakagawa M. 【HCV 】Chair. The 25th Asian Pacific Association for the Study of the Liver 2016.02.22 International Convention Center Pamir, Tokyo(JAPAN)

  181. Kawai-Kitahata F, Asahina Y, Tanaka S, Kakinuma S, Murakawa M, Nitta S, Otani S, Goto F, Nagata H, Kaneko S, Asano Y, Miyoshi M, Tsunoda T, Azuma S, Itsui Y, Nakagawa M, Tanabe M, Maekawa S, Enomoto N, Watanabe M. Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma. The 25th Asian Pacific Association for the Study of the Liver 2016.02.22 International Convention Center Pamir, Tokyo(JAPAN)

  182. Nitta S, Asahina Y, Wakita T, Kato T. In vitro characterization and drug sensitivity analysis for HCV NS5A resistance-associated variants. The 25th Asian Pacific Association for the Study of the Liver 2016.02.22 International Convention Center Pamir, Tokyo(JAPAN)

  183. Nagata H, Sakurai Y, Nakagawa M, Kakinuma S, Azuma S, Murakawa M, Nitta S, Itsui Y, Asahina Y, Watanabe M. Serial changes in M2BPGi levels as predictors of fibrosis and HCC in chronic hepatitis C. The 25th Asian Pacific Association for the Study of the Liver 2016.02.22 International Convention Center Pamir, Tokyo(JAPAN)

  184. Fujii, Satoru , Okamoto, Ryuichi , Nakata, Toru , Suzuki, Kohei , Ishibashi, Fumiaki, Kawamoto, Ami , Segawa, Sayaka Ohashi, Mizutani, Tomohiro , Tsuchiya, Kiichiro, Nakamura, Tetsuya , Watanabe, Mamoru . Establishment of a 3D cell culture-based screening platform to identify natural products that can regulate transepithelial water transport of the human gastrointestinal tract. Pacifichem2015 2015.12.17 Hawaii

  185. Eriko Okada , Akihiro Araki,Sayuri Nitta , Mamoru Watanabe. The utilities and problems of the patency capsule for patients with non-suspected intestinal stenosis. Asian Pacific Digestive Week (APDW) 2015 2015.12.06 Taiwan

  186. Tokai A, Nagaishi T, Watabe T, Jose N, Yamazaki M, Onizawa M, Suzuki M, Hosoya A, Kawai Risa, Adachi T, Watanabe M. CD66a may regulate BCR signaling in the activated B cells. The 44th Annual Meeting of the Japanease Society for Immunology 2015.11.20 Sapporo

  187. Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Nisha J, Tokai A, Hosoya A, Kawai R, Watanabe M. APL may regulate chemokine production by macrophages in the setting of colitis. 第44回日本免疫学会学術集会 2015.11.20 札幌コンベンションセンター(北海道 札幌市)

  188. Shun Kaneko, Sei Kakinuma, Yasuhiro Asahina, Akihide Kamiya, Sayuri Nitta, Tomoyuki Tsunoda, Masato Miyoshi, Hiroko Nagata, Fumio Goto, Satoshi Otani, Miyako Murakawa, Fukiko Kawai-Kitahata, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Mamoru Watanabe.. Human induced pluripotent stem cell-derived hepatic progenitor-like cells and hepatocyte-like cells as a model for interaction between hepatitis B virus and host cells.. AASLD The Liver Meeting 2015 2015.11.16 San Francisco, CA

  189. Miyako Murakawa, Yasuhiro Asahina, Fukiko Kawai-Kitahata, Hiroko Nagata, Syun Kaneko, Sayuri Nitta, Takako Watanabe, Yasuhiro Itsui, Mina Nakagawa, Sei Kakinuma, Sayuki Iijima, Yasuhito Tanaka, Mamoru Watanabe, Yujiro Tanaka. Expression of IFNλ4 in liver is closely associated with non-response to antiviral therapy through the regulation of basal expression of ISGs in chronic hepatitis C patients but not in hepatitis B patients.. AASLD The Liver Meeting 2015 2015.11.13 San Francisco, CA

  190. Takako Watanabe, Yasuhiro Asahina, Mina Nakagawa, Sei Kakinuma, Yasuhiro Itsui, Hiroko Nagata, Miyako Murakawa, Fukiko Kawai-Kitahata, Mika Miura, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe.. Serial change of resistant associated variants during early phase of NS3/4A triple therapy and the final virological outcome: analyses by ultra-deep sequencing technology.. AASLD The Liver Meeting 2015 2015.11.13 San Francisco, CA

  191. S Oshima,Y Matsuzawa,C Maeyashiki,M Kobayashi,Y Nibe,A Ma,M Watanabe. TNFAIP3 promotes survival of CD4 T cells by promoting autophagy. Cell Death and Immunity 2015.11.10 Berkeley

  192. Taro Watabe, Takashi Nagaishi, Masahiro Suzuki, Motomi Yamazaki, Michio Onizawa, Nisha Jose, Arisa Tokai, Akinori Hosoya, Risa Kawai, Mamoru Totsuka, Mamoru Watanabe. Epithelial TNFR2 signaling in the setting of ibd may be involved in the development of colitis-associated carcinogenesis . UEGW2015 2015.10.28 Barcelona

  193. Tomoaki Shirasaki, Keita Fukushima, Kiichirou Tsuchiya, Shuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. TNF-α stabilizes atoh1 protein in colitis-associated colorectal cancer resulting in enhanced malignant potential. . UEGW2015 2015.10.28 Barcelona

  194. Kiichiro Tsuchiya, Ryohei Hayashi, Shuji Hibiya, Keita Fukushima, Nobukatsu Horita, Tomoaki Shirasaki, Mamoru Watanabe. Mapping biopsy of entire small intestine revealed specific gene expression in crohn's disease . UEGW2015 2015.10.27 Barcelona

  195. Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima , Ryuichi Okamoto, Tetsuya Nakamura,Mamoru Watanabe. Contiuous stimulation with cytokines leads to irreversible activation of NF-γb signaling in colonic epithelial cells by organoid culture . UEGW2015 2015.10.27 Barcelona

  196. K. Matsuoka, E. Saito, M. Watanabe. Salvage therapy for corticosteroid-refractory ulcerative colitis patients: Results from the real-life clinical practice.. JDDW2015 2015.10.10 Tokyo

  197. Kiichiro Tsuchiya, Shuji Hibiya, Mamoru Watanabe. Acquisition of enhanced malignant potential in inflammation associated colon cancer. The 74th Annual Meeting of the Japanese Cancer Association 2015.10.09 Nagoya

  198. Taro Watabe, Takashi Nagaishi, Masahiro Suzuki, Motomi Yamazaki, Nisha Jose, Arisa Tokai, Akinori Hosoya . Type 2 TNF receptor signaling in the epithelia may be involved in the development of colitis-associated carcinogenesis. The 74th Annual Meeting of the Japanese Cancer Association 2015.10.08 Nagoya

  199. Mamoru Watanabe. Adult Tissue Stem Cell Therapy in Inflammatory Bowel Disease. IBD Advisory Board Meeting 2015.10.03 Tokyo

  200. 大島 茂、前屋舗千明、仁部洋一、小林正典、松沢 優、鬼澤道夫、Averil Ma、渡辺 守. TNFAIP3 によるネクロプトーシス制御機構の解明. 第24回日本Cell Death学会学術集会 2015.07.11 大阪

  201. Mamoru Watanabe. 【Luncheon Symposium】Chair. AOCC2015 2015.06.20 Beijing

  202. Mamoru Watanabe. Closing Remarks. AOCC2015 2015.06.20 Beijing

  203. Mamoru Watanabe. The Future Perspective of IBD in Asia. AOCC2015 2015.06.20 Beijing

  204. Nobuyuki Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Tomohiro Mizutani, Ryuichi Okamoto, Testuya Nakamura and Mamoru Watanabe. A novel fluorescent labelling system into small intestinal organoid reveals independent long-lived intestinal stem cells in a crypt.. AOCC2015 2015.06.20 Beijing

  205. Akinori Hosoya, Takashi Nagaishi, Taro Watanabe, Mashiro Suzuki, Motomi Yamazaki, Michio Onizawa, Nisha Jose, Arisa Tokai, Lisa Kawai, Mamoru Watanabe. TNFR2 signaling in colonic epithelia may be involved in the development of colitis-associated carcinogenesis.. AOCC2015 2015.06.20 Beijing

  206. Tomoaki Shirasaki, Keita Fukushima, Kiichiro Tsuchiya, Shuuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Atoh1 protein stabilized by TNF-α acquires enhanced malignant potential in colitis-associated colorectal cancer. AOCC2015 2015.06.19 Beijing

  207. Toshimitsu Fujii, Kento Takenaka, Yoshio Kitazume, Eriko Saito, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. Modifying and validating endoscopic and magnetic resonance scoring systems for the deep small intestine in Crohn’s disease. AOCC2015 2015.06.19 Beijing

  208. Kohei Suzuki,Satoru Fujii,Toru Nakata,Ami Kawamoto,Fumiaki Ishibashi,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya,Kazuo Otsuka,Tetsuya Nakamura, Ryuichi Okamoto, Mamoru Watanabe . Enrichment of Intestinal Stem Cells by the 3D-Culture of IBD Patient Derived Intestinal epithelium. AOCC2015 2015.06.19 Beijing

  209. Matsuzawa Y, Oshima S, Ma Averil , Watanabe M. A Crohn's disease susceptibility gene A20 promotes autophagy by restricting mTOR in CD4 T cells. GI Research Academy 2015 2015.06.12 Tokyo

  210. Watanabe M. Stem Cell Transplantation in Inflammatory Bowel Disease (IBD). Guangzhou International GI Summit(GIGIS2015) 2015.06.06 Guangzhou

  211. Toru Nakata, Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Go Ito, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe. Distinct Role of Notch Ligands, DLL1 and Dll4, in Normal and in Tumor Intestinal Epithelium. DDW 2015 2015.05.19 Washington, D.C.

  212. Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Continuous Stimulation With Cytokines Leads to Irreversible Accumulation of NF-kB Signaling in Colonic Epithelial Cells. DDW 2015 2015.05.19 Washinguton DC

  213. Ryohei Hayashi, Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Nobukatsu Horita, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Mamoru Watanabe. Human Alpha-Defensin 6 Regulated by the Cooperation of Beta-Catenin and ATOH1, Might Be the Pathogenesis of Crohn's Disease. DDW 2015 2015.05.18 Washington, D.C.

  214. Takashi Nagaishi, Taro Watabe, Masahiro Suzuki, Motomi Yamazaki, Nisha Jose, Arisa Tokai, Akinori Hosoya, Mamoru Watanabe. Epithelial NF-kB Activation via TNF Signaling May Be Involved in the Development of Colitis-Associated Carcinogenesis. DDW 2015 2015.05.18 Washington, D.C.

  215. Keita Fukushima, Kiichiro Tsuchiya, Shuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Yoshihito Kano, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Atoh1 Protein Expression by TNF-a and the Acquisition of Malignant Potential in Colitis- Associated Colorectal Cancer. DDW 2015 2015.05.17 Washington, D.C.

  216. Toshimitsu Fujii, Kento Takenaka, Eiko Saito, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. Modifying and Validating Endoscopic and Magnetic Resonance Scoring Systems for the Deep Small Intestine in Crohn's Disease. DDW 2015 2015.05.17 Washington, D.C.

  217. Yu Matsuzawa, Shigeru Oshima, Masanori Kobayashi, Yoichi Nibe, Chiaki Maeyashiki, Averil I. Ma, Mamoru Watanabe. A Crohn's Disease Susceptibility Gene A20 Regulates Autophagy Dynamics in CD4 T Cells. DDW 2015 2015.05.17 Washington, D.C.

  218. Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Toru Nakata, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe. Notch Ligands DLL1 and Dll4 Are Expressed by Distinct Population of Epithelial Cells in the Mice Intestine. DDW 2015 2015.05.16 Washington, D.C.

  219. Masakazu Nagahori, Mamoru Watanabe. The Prognosis of Ulcerative Colitis Patients Who Are Treated With Corticosteroid in an Academic Inflammatory Bowel Disease Center and Community Hospitals. DDW 2015 2015.05.16 Washington, D.C.

  220. Shiro Yui, Jordi Guiu, Pawel Schweiger, Carsten Friis Rundsen, Kim Jensen. The Cellular Plasticity of Adult and Fetal Intestinal Epithelium and its functional Evaluation by Grafting Assay. DDW 2015 2015.05.16 Washington, D.C.

  221. Katsuyoshi Matsuoka,Makoto Naganuma,Takanori Kanai. New drug development for inflammatory bowel disease in Japan:an example of collaboration between academia, industry, and government. 第101回日本消化器病学会総会 2015.04.25 仙台

  222. Satoshi Otani,Sei Kakinuma,Mamoru Watanabe. Matrix Metalloproteinase(MMP)-14 regulates the differentiation of hepatic stem/progenitor cells. The 3rd JSGE International Topic Conference 2015.04.25 Sendai

  223. Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shun Kaneko, Hiroko Nagata, Fumio Goto, Satoshi Otani, Miki Taniguchi, Miyako Murakawa, Sayuri Nitta, Takako Watanabe, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Shinji Tanaka , Minoru Tanabe, Nobuyuki Enomoto and Mamoru Watanabe. Gene alterations in TERT promoter, CTNNB1, and TP53 are closely associated with development and prognosis of hepatocellular carcinoma : Comprehensive analyses by next generation sequencing technology. The 3rd JSGE International Topic Conference 2015.04.24 仙台

  224. Asahina Y, Kawai-Kitahata F, Kaneko S, Nagata H, Goto F, Otani S, Taniguchi M, Murakawa M, Nitta S, Watanabe T, Tasaka-Fujita M, Nishimura-Sakurai Y, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Tanaka S, Tanabe M, Enomoto N, Watanabe M. Gene alterations in tert promoter, CTNNB1, and TP53 are closely associated with development and prognosis of hepatocellular carcinoma: comprehensive analyses by next generation sequencing technology. 50th The International liver congress TM 2015 2015.04.22 Vienna

  225. Matsuoka K,Kuwahara E,Nishiwaki Y,Watanabe M. Epidemiology and temporal change of IBD management in Japan: Results from the Japanese IBD registry data.. Annual Meeting of KASID 2015 2015.04.19 Seoul

  226. Nozaki K, Mochizuki W, Matsumoto Y, Matsumoto T, Fukuda M, Mizutani T, Watanabe M, Nakamura T. Live imaging analysis of intraepithelial lymphocytes (IELs) co-cultured with intestinal epithelial organoids.. Cold Spring Harbor Meeting "Fundamental Immunology and Its Therapeutic Applications" 2015.04.16 New York

  227. Tsuchiya K, Fukushima K, Watanabe M. The acquisition of cancer stemness by Atoh1 in colitis associated cancer. 8th Annual World Congress of Regenerative Medicine & Stem Cells 2015.03.21 韓国

  228. Hibiya S, Tsuchiya K, Fukushima K, Hayashi R, Horita N, Kano Y, Okamoto R, Nakamura T, Watanabe M. Continous stimulation with cytokines leads to irreversible accumulation of NF-κB signaling in colonic epithelial cells. The 5th International Symposium on Carcinogenic Spiral 2015.02.26 Kobe

  229. Matsuoka K, Saito E, Fujii T, Takenaka K, Nagahori M, Ohtsuka K, Watanabe M. The Ulcerative Colitis Endscopic Index of Severity (UCEIS) is useful to evaluate endoscopic improvement and to predict medium-term prognosis in Ulcerative Colitis patients treated with tacrolimus. 10th Congress of ECCO - Inflammatory Bowel Diseases 2015 2015.02.20 Barcelona

  230. Tsuchiya K, Fukushima K, Watanabe M. The acquisition of cancer stemness by Atoh1 in colitis associated cancer. 10th Congress of ECCO - Inflammatory Bowel Diseases 2015 2015.02.20 Barcelona

  231. Hibiya S, Tsuchiya K, Fukushima K, Hayashi R, Horita N, Oshima S, Okamoto R, Nakamura T, Watanabe M. Long-term stimulation with cytokines acquires irreersible accumulation of NF-κB signaling in colonic epithelial cells. 10th Congress of ECCO - Inflammatory Bowel Diseases 2015 2015.02.20 Barcelona

  232. Hayashi R, Tsuchiya K, Hibiya S, Fukushima K, Horita N, Okada E, Araki A, Ohtsuka K, Watanabe M. Human alpha-defensin 6 regulated by both Atoh1 and beta-catenin might be the pathogenesis of Japanese Crohn's Disease. 10th Congress of ECCO - Inflammatory Bowel Diseases 2015 2015.02.20 Barcelona

  233. Y. Suzuki, S. Motoya, F. Hirai, H. Ogata, H. Ito, N. Sato, K. Ozaki, M. Watanabe, T. Hibi. Infliximab therapy for Japanese patients with Ulcerative Colitis: Efficacy, safety, and association between serum infliximab levels and early response in a randomized, double-blind, placebocontrolled study. 10th Congress of ECCO - Inflammatory Bowel Diseases 2015 2015.02.19 Barcelona

  234. Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Totsuka M, Yagita H, Watanabe M. TNFR2 signaling in the epithelia may be involved in the development of colitis-associated tumor. The 43rd Annual Meeting of The Japanese Society for Immunology 2014.12.12 Kyoto

  235. Watanabe M. IBD: The New Emerging Diseases in Asia-Pacific. Challenges of IBD in Asia - from diagnosis to management. APDW2014 2014.11.24 Bali

  236. Watanabe M. Colorectal Neoplasm. Molecular mechanism of inflammation–associated colorectal cancer. APDW2014 2014.11.24 Bali

  237. Nishida N, Sawai H, Kashiwase K, Minami M, Yamamoto K, Sasazuki T, Sugiyama M, Wai-Kay Seto , Man-Fun Yuen, Yong Poovorawan, Sang Hoon Ahn, Kwang-Hyub Han, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Jong-Hon Kang, Hige S, Ide T, Yamamoto K, Sakaida I, Murawaki Y, Itoh Y, Tamori A, Orito E, Hiasa Y, Honda M, Kaneko S, Mita E, Suzuki K, Hino K, Tanaka E, Mochida S, Watanabe M, Eguchi Y, Korenaga M, Kawashima M, Tokunaga K, Mizokami M. Assiciations of HLA-DPB1 with CHB infection and HBV related HCC in Asia. The 65th. Annual Meeting of American Association for the Study of Liver Diseases(AASLD The Liver Meeting 2014) 2014.11.11 Boston

  238. Murakawa M, Asahina Y, Nakagawa M, Kawai-Kitahata F, Taniguchi M, Nitta S, Watanabe T, Itsui Y, Kakinuma S, Sakamoto N, Watanabe M. Expression of IFNλ4 in liver and PBMC is closely associated with higher basal expression of ISGs and impaired induction of IL28B by interferon treatment in chronic hepatitis C non-responder patients. The 65th. Annual Meeting of American Association for the Study of Liver Diseases(AASLD The Liver Meeting 2014) 2014.11.11 Boston

  239. Otani S, Kakinuma S, Watanabe M. Matrix Metalloproteinase-14 regulates the maturation of fetal hepatic stem/progenitor cells in mice. The 65th. Annual Meeting of American Association for the Study of Liver Diseases(AASLD The Liver Meeting 2014) 2014.11.11 Boston

  240. Watanabe T, Asahina Y, Nakagawa M, Kakinuma S, Itsui Y, Taniguchi M, Murakawa M, Nagata H, Miura M, Maekawa S, Enomoto N, Watanabe M. Emergence or selection of resistant associated variant immediately after initiation of the therapy is predictive for failure of direct acting antiviral therapy:ultra-deep sequencing analyses for serial time points. The 65th. Annual Meeting of American Association for the Study of Liver Diseases(AASLD The Liver Meeting 2014) 2014.11.11 Boston

  241. Kawai-Kitahata F, Asahina Y, Kaneko S, Nagata H, Goto F, Otani S, Taniguchi M , Murakawa M , Nitta S, Watanabe T, Itsui Y, Nakagawa M, Kakinuma S, Enomoto N, Watanabe M. Gene alterations in β-catenin and p53/cell cycle control pathway are closely associated with development and prognosis of hepatocellular carcinoma: Comprehensive analyses by next generation sequencing technology. The 65th. Annual Meeting of American Association for the Study of Liver Diseases(AASLD The Liver Meeting 2014) 2014.11.10 Boston

  242. Nakagawa M, Asahina Y, Taniguchi M, Watanabe T, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Tanaka Y, Watanabe M. Impact of host and therapeutic factors and resistant associated variants on response to interferon based-direct acting antiviral treatment in difficult-to-treat chronic hepatitis C patients. The 65th. Annual Meeting of American Association for the Study of Liver Diseases(AASLD The Liver Meeting 2014) 2014.11.09 Boston

  243. Watanabe M. Role of Cyclosporin/Tacrolimus:Tacrolimus and infliximab in patients with refractory ulcerative colitis. TSIBD2014 2014.11.09 Taipei

  244. Watanabe M. Stem cell transplantation in IBD, are we there yet?. New Advance in Cancer and Stem Cell 2014.11.08 Kaohsinng

  245. 伊藤 剛,藤井 悟,岡本隆一,渡辺 守. ヒト腸上皮培養系を用いたイオンチャネル機能制御機構の解析. 第5回Japan Gut Forum 2014.11.01 東京

  246. Watanabe M. Novel Therapies for Inflammatory Bowel Disease Stemcelltherapy:what,when,andhow?. SIDDS2014 2014.10.27 Seoul

  247. Takenaka K, Ohtsuka K, Watanabe M. Enteroscopic and MR findings of small intestine in Crohn's disease. Japan Digesive Disease Weeks 2014 2014.10.26 Kobe

  248. Matsuoka K, Naganuma M, Kanai T. The Ulserative Colitis Endoscopic Index of Severity (UCEIS) is useful to evaluate endoscopic improvement and to predict medium-term prognosis in ulcerative colitis patients treated with tacrolimus. Japan Digesive Disease Weeks 2014 2014.10.26 神戸

  249. Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Azuma S, Asahina Y, Watanabe M. Matrix Metalloproteinase-14 controls differentiation of fetal hepatic stem/progenitor cells. 第18回日本肝臓学会大会(JDDW2014) 2014.10.23 神戸

  250. Jose N, Nagaishi T, Watabe T, Tokai A, Suzuki M, Yamazaki M, Watanabe M. The expression of myosin light chain kinase induced by NK-KB activation is involved in the development of colitis-associated cancer. UEGW2014 2014.10.22 Vienna

  251. Hayashi R, Tsuchiya K, Hibiya S, Fukushima K, Horita N, Okada E, Araki A, Ohtsuka K, Watanabe M. Human alpha-defensin 6 regulated by both atoh1 and beta-catenin might be the pathogeneses of crohn's disease. UEGW2014 2014.10.22 Vienna

  252. Okamoto R, Ito G, Shimizu H, Fujii S, Nakata T, Suzuki K, Watanabe M. Notch signaling regulates expression of gelsolin superfamily genes, gelsolim and scinderin and promotes re-assembly of action cytoskeleton in human intestinal epithelial cells.. UEGW2014 2014.10.22 Vienna

  253. Ito G, Okamoto R, Shimizu H, Fujii S, Nakata T, Suzuki K, Tsuchiya K, Nakamura T, Watanabe M. Notch Signaling and TNF-α synergistically promotes intracellular protein accumulation of olfm4 in the inflamed mucosa of ulcerative colitis. UEGW2014 2014.10.21 Vienna

  254. Matsuzawa Y, Oshima S, Takahara M, Nozaki K, Kobayashi M, Nibe Y, Maeyashiki C, Nemoto Y, Ma A, Watanabe M. A ubiquitin-modifying enzyme A20 controls the dynamics of autophagy. UEGW2014 2014.10.21 Vienna

  255. Fujii T, Naganuma M, Kitazume Y, Takenaka K, Nagahori M, Saito E, Ohtsuka K, Watanabe M. MR enterocolonography can identify patients who need additional treatment by predicting recurrence, hospitalization and surgey of Crohn's disease patients in remission. UEGW2014 2014.10.20 Vienna

  256. Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Watanabe M. Magnetic resonance enterocolonography can detect small intestinal active lesions in crohn's disease;comparison with balloon enteroscopy. UEGW2014 2014.10.20 Vienna

  257. Watanabe M. Gut as a second brain to regulate human whole body ?. Cluster Lectures 2014.10.14 Hamburg

  258. Tsuchiya K, Hibiya S, Watanabe M. Innate immune spiral of intestinal epithelial cells by the longterm inflammation. The 73rd Annual Meeting of the Japanese Cancer Association 2014.09.25 Yokohama

  259. 4. Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Notch signaling and TNF-α synergistically promotes intracellular protein expression of OLFM4 in human intestinal epithelial cells. The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis 2014.06.21 Seoul

  260. Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe. Distinct Expression Patterns of Notch Ligands, DLL1 and DLL4, in Normal and Inflamed Mice Intestine. The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis 2014.06.21 Seoul

  261. Matsuoka k. Management of intra-abdominal abscess and stricture. The 2nd Annual Meeting of AOCC 2014.06.21 Seoul

  262. Takenaka K, Otsuka K, Nagahori M, Fujii T, Saito E, Watanabe M. Comparison of Magnetic Resonance and Balloon Enteroscopic Examination of Deep Small Intestine in Patients with Crohn's Disease. The 2nd Annual Meeting of AOCC 2014.06.20 Seoul

  263. Saito E, Nagahori M, Waranabe M. Outcome of induction and maintenance therapy for refractory ulceractry colitis. The 2nd Annual Meeting of AOCC 2014.06.20 Seoul

  264. Watanabe M. Basic Forum 1. Emerging New Concepts in IBD: Genetics and stem cell.( Chair). The 2nd Annual Meeting of AOCC 2014.06.20 Seoul

  265. Watanabe M. Stem cell as a promising target for IBD:From the bench to the bedside. The 2nd Annual Meeting of AOCC 2014.06.20 Seoul

  266. Fukuda M, Mizutani T, Mochiduki W, Taichi M, Nozaki K, Ichinose S, Watanabe M, Nakamura T.. Successful Engraftment of Cultured Small Intestinal Epithelial Stem Cells onto Damaged Colonic Mucosa by Heterotopic Transplantation. I2th Interational society for stem cell research 2014.06.19 Vancouver

  267. Mizutani T. Successful Engraftment of Cultured Small Intestinal Epithelial Stem Cells onto Damaged Colonic Mucosa by Heterotopic Transplantation. GI Research Academy 2014 2014.06.06 Tokyo

  268. Watanabe M, Yoshimura N, Motoya S, Tominaga K, Iwakiri R, Watanabe K, Hibi T. AJM300, an oral α4 integrin antagonist, for active ulcerative colitis: a multicenter, randomized, doubleblind,placebo-controlled phase 2a study. Digestive Disease Week 2014 2014.05.04 Chicago

  269. Mizutani T, Fukuda M, Mochizuki W, Matsumoto T, Nozaki K, Ichinose S, Watanabe M, Nakamura T. Successful Engraftment of Cultured Small Intestinal Epithelial Stem Cells onto Damaged Colonic Mucosa by Heterotopic Transplantation. Digestive Disease Week 2014 2014.05.03 Chicago

  270. Tsuchiya K, Watanabe M. Molecular mechanism in the pathogenesis of the colitis-associated colorectal cancer. 第32回Cytoprotection 研究会 2014.03.23 京都

  271. Takenaka K, Otsuka K, Nagahori M, Fujii T, Saito E, Watanabe M. Comparing MR enterocolonography to enteroscopy in Crohn's disease, especially focusing on small intestinal findings. 9th congress of European Crohn's and Colitis Organisation 2014.02.20 Copenhagen

  272. Hibiya S, Tsuchiya K, Fukushima K, Hayashi R, Horita N, Kano Y , Okamoto R, Nakamura T,Watanabe M. Long-term stimulation with cytokines acquires irreversible accumulation of NF-κB signaling in primary colonic epithelial cells. 4th International Symposium on Carcinogenic Spiral 2014.02.11 Sapporo

  273. 岡本隆一,村野竜朗,伊藤 剛,中田 徹,日比谷秀爾,藤井 悟,清水寛路,水谷知裕,土屋輝一郎,中村哲也,渡辺 守. 炎症性腸疾患におけるNotch-Hes1シグナルを介した粘膜再生機構の解析. 浜名湖シンポジウム 2013.12.21 浜松

  274. 谷口未樹、中川美奈、 朝比奈靖浩 柿沼 晴、東 正新、渡辺貴子、櫻井 幸、村川美也子、大谷賢志、河合富貴子、後藤文男、坂本直哉、渡辺 守. 慢性肝疾患における肝細胞癌とIL-6 の関連. 第49回日本肝臓学会総会 2013.06.06 京王プラザホテル(東京都新宿区)

  275. 新田沙由梨、朝比奈靖浩、柿沼 晴、坂本直哉、渡辺 守. ウイルス肝炎における自然免疫応答抑制メカニズムの解析. Liver Forum in Kyoto 第16回学術集会 2013.03.29 京都

  276. Mizutani T, Nakamura T, Morikawa R, Fukuda M, Mochizuki W, Yamauchi Y, Nozaki K, Yui S, Okamoto R, Tsuchiya K, Watanabe M. Real-time analysis of p-glycoprotein-mediated drug transport across primary intestinal epitherial cells three-dimensionally cultured in vitro. DDW 2012 2012.05.19 San Diego

  277. Fujii T, Naganuma M, Saito E, Nagahori M, Watanabe M. Intravenous tacrolimus therapy can rapidly induce remission in refractory ulcerative colitis. DDW2012 2012.05.19 San Diego

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Patents 【 display / non-display

  • CULTURING COLORECTAL EPITHELIAL STEM CELLS AND TRANSPLANTING COLORECTAL EPITHELIUM

    Patent Number: 2772534