Personnel Information

写真a

MASUDA Takao


Job title

Associate Professor

Research Areas, Keywords

Human Immunodeficiency Virus, Integrtase

Graduating School 【 display / non-display

  • Waseda University, 1985, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Master's Course, 1987, Completed

Degree 【 display / non-display

  • Ph.D, Kumamoto University

Campus Career 【 display / non-display

  • 1900.01
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Immunotherapeutics, Associate Professor
  • 2018.04
    -
    2020.05
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Immunotherapeutics, Associate Professor
  • 2020.06
    -
    2022.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Immunotherapeutics, Associate Professor
  • 2022.04
    -
    Now
    Tokyo Medical and Dental University, Faculty of Medicine, Associate Professor

Research Areas 【 display / non-display

  • Virology

 

Published Papers & Misc 【 display / non-display

  1. Camille Michiko Obayashi, Yoko Shinohara, Takao Masuda, Gota Kawai. Influence of the 5'-terminal sequences on the 5'-UTR structure of HIV-1 genomic RNA. Sci Rep. 2021.05; 11 (1): 10920. ( PubMed, DOI )

  2. Yu-Lun Huang, Gota Kawai, Atsuhiko Hasegawa, Mari Kannagi, Takao Masuda. Impact of 5'-end nucleotide modifications of HIV-1 genomic RNA on reverse transcription. Biochem. Biophys. Res. Commun.. 2019.07; ( PubMed, DOI )

  3. Tatsuro Takahata, Eri Takeda, Minoru Tobiume, Kenzo Tokunaga, Masaru Yokoyama, Yu-Lun Huang, Atsuhiko Hasegawa, Tatsuo Shioda, Hironori Sato, Mari Kannagi, Takao Masuda. Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase. Journal od Virology. 2017.01; 91 (1): ( PubMed, DOI )

  4. Kondo Nobuyo, Nagano Yoshiko, Hasegawa Atsuhiko, Ishizawa Miku, Katagiri Kuniko, Yoneda Takeru, Masuda Takao, Kannagi Mari. Involvement of EZH2 inhibition in lenalidomide and pomalidomide-mediated growth suppression in HTLV-1-infected cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021.10; 574 104-109. ( PubMed, DOI )

  5. Miku Ishizawa, Undrakh Ganbaatar, Atsuhiko Hasegawa, Natsuko Takatsuka, Nobuyo Kondo, Takeru Yoneda, Kuniko Katagiri, Takao Masuda, Atae Utsunomiya, Mari Kannagi. Short-term cultured autologous peripheral blood mononuclear cells as a potential immunogen to activate Tax-specific CTL response in adult T-cell leukemia patients. Cancer Sci. 2021.03; 112 (3): 1161-1172. ( PubMed, DOI )

  6. Ishizawa Miku, Ganbaatar Undrakh, Hasegawa Atsuhiko, Takatsuka Natsuko, Kondo Nobuyo, Yoneda Takeru, Katagiri Kuniko, Masuda Takao, Utsunomiya Atae, Kannagi Mari. Short-term cultured autologous peripheral blood mononuclear cells as a potential immunogen to activate Tax-specific CTL response in adult T-cell leukemia patients(和訳中) Cancer Science. 2021.03; 112 (3): 1161-1172. ( ichushi )

  7. Hasegawa Atsuhiko, Murata Megumi, Fujikawa Tomoka, Nagano Yoshiko, Akari Hirofumi, Masuda Takao, Kannagi Mari. Restoration of impaired STLV-1-specific CTL response in STLV-1-infected Japanese macaques by a CTL-based vaccine CANCER SCIENCE. 2021.02; 112 618.

  8. 長谷川 温彦, 村田 めぐみ, 冨士川 朋夏, 永野 佳子, 明里 宏文, 増田 貴夫, 神奈木 真理. STLV-1感染ニホンザルを用いたCTL誘導型ワクチンによるSTLV-1特異的CTL低応答の改善 日本癌学会総会記事. 2020.10; 79回 PE3-1. ( ichushi )

  9. 永野 佳子, チョウ・カンシュン , 長谷川 温彦, 片桐 邦子, 近藤 伸世, 増田 貴夫, 神奈木 真理. HTLV1感染細胞の細胞増殖シグナル伝達の調節におけるIRF4の役割(Roles of IRF4 in the regulation of cell growth signaling in HTLV-1-infected cells) 日本生化学会大会プログラム・講演要旨集. 2020.09; 93回 [P-522]. ( ichushi )

  10. Hasegawa Atsuhiko, Fujikawa Tomoka, Ganbaatar Undrakh, Nagano Yoshiko, Masuda Takao, Tanaka Yuetsu, Akari Hirofumi, Kannagi Mari. Impaired T-cell responses in natural infection of STLV-1 as a primate model of immune suppression in HTLV-1 infection CANCER SCIENCE. 2018.12; 109 643.

  11. Hideki Saito, Hiroaki Takeuchi, Takao Masuda, Takeshi Noda, Shoji Yamaoka. N-terminally truncated POM121C inhibits HIV-1 replication. PLoS ONE. 2017.09; 12 (9): e0182434. ( PubMed, DOI )

  12. Leila Sawada, Yoshiko Nagano, Atsuhiko Hasegawa, Hikari Kanai, Kai Nogami, Sayaka Ito, Tomoo Sato, Yoshihisa Yamano, Yuetsu Tanaka, Takao Masuda, Mari Kannagi. IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways. PLoS Pathog.. 2017.09; 13 (9): e1006597. ( PubMed, DOI )

  13. Satomi Ando, Atsuhiko Hasegawa, Yuji Murakami, Na Zeng, Natsuko Takatsuka, Yasuhiro Maeda, Takao Masuda, Youko Suehiro, Mari Kannagi. HTLV-1 Tax-Specific CTL Epitope-Pulsed Dendritic Cell Therapy Reduces Proviral Load in Infected Rats with Immune Tolerance against Tax. J. Immunol.. 2017.02; 198 (3): 1210-1219. ( PubMed, DOI )

  14. Yuji Murakami, Atsuhiko Hasegawa, Satomi Ando, Reiko Tanaka, Takao Masuda, Yuetsu Tanaka, Mari Kannagi. A novel mother-to-child HTLV-1 transmission model for investigating the role of maternal anti-HTLV-1 antibodies using orally infected mother rats. J. Gen. Virol.. 2017.02; ( PubMed, DOI )

  15. Masako Nomaguchi, Naoya Doi, Yosuke Sakai, Hirotaka Ode, Yasumasa Iwatani, Takamasa Ueno, Yui Matsumoto, Yasuyuki Miyazaki, Takao Masuda, Akio Adachi. Natural Single-Nucleotide Variations in the HIV-1 Genomic SA1prox Region Can Alter Viral Replication Ability by Regulating Vif Expression Levels. J. Virol.. 2016.05; 90 (9): 4563-4578. ( PubMed, DOI )

  16. Takao Masuda, Yoko Sato, Yu-Lun Huang, Satoshi Koi, Tatsuro Takahata, Atsuhiko Hasegawa, Gota Kawai, Mari Kannagi. Fate of HIV-1 cDNA intermediates during reverse transcription is dictated by transcription initiation site of virus genomic RNA. Sci Rep. 2015; 5 17680. ( PubMed, DOI )

  17. Masako Nomaguchi, Ariko Miyake, Naoya Doi, Sachi Fujiwara, Yasuyuki Miyazaki, Yasuko Tsunetsugu-Yokota, Masaru Yokoyama, Hironori Sato, Takao Masuda, Akio Adachi. Natural single-nucleotide polymorphisms in the 3' region of the HIV-1 pol gene modulate viral replication ability. J. Virol.. 2014.04; 88 (8): 4145-4160. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. 大林カミーユ美智子,篠原陽子,増田貴夫,河合剛太. HIV-1ゲノムRNAの5’末端の違いが構造と機能に与える影響. 第42回 分子生物学会 2019.12.03 福岡

  2. Takao Masuda, Yu-Lun Huang, Paoling Wang, Atsuhiko Hasegawa, Mari Kannagi. Evaluation of HIV-1 integrase in fusion with reverse-transcriptase in vitro.. 第66回日本ウイルス学会学術集会( 2018.10.28 京都

  3. Tsutomu Murakami, Masayuki Fujino, Masaru Yokoyama, Takuya Kobayakawa, Hiroaki Takeuchi, Takao Masuda, Osamu Kotani, Hirokazu Tamamura, Hironori Sato. Biological and molecular characterization of a novel anti-HIV-1 compound created by in silico design and de novo organic synthesis.. Cold Spring Harbor Laboratory Meeting, Retroviruses 2018.05.21 NY (USA)

  4. 米田 建、永野 佳子、長谷川 温彦、近藤 伸世、石澤 未来、松岡 将太郎、増田 貴夫、神奈木 真理. 免疫調節薬レナリドミドはHTLV-1感染細胞のサイトカイン産生に影響し増殖を抑制する. 第67回 日本ウイルス学会学術集会 2019.10.29 東京

  5. 永野 佳子, Zhang Jianchun, 長谷川 温彦, 増田 貴夫, 神奈木 真理. IRF4制御によるHTLV-1感染細胞の増殖抑制はSOCS3発現の増加を伴う(Growth inhibition of HTLV-1-infected cells by regulation of IRF4 is accompanied by increased SOCS3 expression). 日本癌学会総会記事 2019.09.01

  6. 神奈木 真理, 永野 佳子, 米田 建, Zhang Jian-Chun, 増田 貴夫, 長谷川 温彦. LenalidomideはIRF4とIL-10の抑制を介してHTLV-1感染細胞の増殖を抑制する(Lenalidomide inhibits proliferation of HTLV-1-infected cells through suppression of IRF4 and IL-10). 日本癌学会総会記事 2019.09.01

  7. Ganbaatar Undrakh, Hasegawa Atsuhiko, Miyazawa Rinsaku, Masuda Takao, Kannagi Mari. Cancer immunotherapy-2 Mitomycin C-induced HTLV-1-infected cell death leads to enhanced phagocytosis by dendritic cells and macrophages compared to Doxorubicin-induced cell death(和訳中). 日本免疫学会総会・学術集会記録 2018.12.01

  8. 長谷川 温彦, 冨士川 朋夏, Ganbaatar Undrakh, 永野 佳子, 増田 貴夫, 田中 勇悦, 明里 宏文, 神奈木 真理. HTLV-1感染におけるT細胞免疫抑制の霊長類モデルとしてのSTLV-1自然感染ニホンザル(Impaired T-cell responses in natural infection of STLV-1 as a primate model of immune suppression in HTLV-1 infection). 日本癌学会総会記事 2018.09.01

  9. Undrakh Ganbaatar,Satomi Ando,Takao Masuda,Mari Kannagi,Atsuhiko Hasegawa. Selective dysfunction of HTLV-1-specific T cells in orally infected rats. The 65th Annual Meeting of the Japanese Society for Virology 2017.10.24 Osaka

  10. Takao Masuda, Tatsuro Takahata, Yu-Lun Huang, Atsuhiko Hasegawa, Mari Kannagi. . Non-enzymatic role of HIV-1 Integrase through RT-IN precursor form. . The 65th Annual Meeting of the Japanese Society for Virology 2017.10.24 Osaka

  11. Yu-Lun Huang, Tatsuro Takahata1、Atsuhiko Hasegawa, Gota Kawai, Mari Kannagi , and Takao Masuda . Role of 5’-end modification of HIV-1 RNA during reverse transcription.. The 64th Annual Meeting of the Japanese Society for Virology 2016.10.23 Sapporo

  12. Takao Masuda, Yoko Sato, Yu-Lun Huang, Satoshi Koi, Tatsuro Takahata, Atsuhiko Hasegawa, Gota Kawai , Mari Kannagi.. In vitro reconstitution of HIV-1 reverse transcription revealed an unprecedented role of 5’-end of viral RNA for reverse transcription.. 第63回日本ウイルス学会学術集会 2015.11.30 福岡

  13. Takao Masuda. Non-enzymatic roles of retroviral integrase: the next target for novel anti-HIV drug development. HIV enzymes - structure, function and inhibition 2015.03.19 Tsudanuma

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