Personnel Information

写真a

KARASUYAMA Hajime


Job title

Project Professor

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519

Laboratory Phone number

+81-3-5803-4609

Laboratory Fax number

+81-3-3814-7172

Mail Address

karasuyama.mbch@tmd.ac.jp

Homepage URL

http://immune-regulation.org/index.php?id=27

Research Areas, Keywords

allergy, basophil, B cell development, immunodeficiency, autoimmune, infection

Field Introduction URL

Inflammation, Infection & Immunity Laboratory

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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 1978, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Doctor's Course, 1984, Completed

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Degree 【 display / non-display 】

  • MD., PhD., The University of Tokyo

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Campus Career 【 display / non-display 】

  • 2000.10
    -
    2019.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Immune Regulation， Professor
  • 2008.04
    -
    2014.03
    Tokyo Medical and Dental University， Executive Vice President， Deputy Director
  • 2014.04
    -
    2020.03
    Tokyo Medical and Dental University， Board Member， Executive Director
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， ， Distinguished Professor
  • 2020.10
    -
    2021.01
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， Deputy Director
  • 2021.02
    -
    2022.06
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， Deputy Director
  • 2022.07
    -
    2023.04
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， ， Inflammation, Infection and Immunity Laboratory， Deputy Director
  • 2023.05
    -
    2024.03
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， ， Inflammation, Infection and Immunity Laboratory， Distinguished Professor
  • 2024.04
    -
    Now
    Tokyo Medical and Dental University， Institute of Research， Project Professor

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External Career 【 display / non-display 】

  • 1978 Tokyo Medical and Dental University School of Medicine MD.1978,
  • 1980-1984 Postgraduate, Department of Immunology, Faculty of Medicine, University of Tokyo,
  • PhD., 1984.,
  • 1984-1987 Scientific member, Basel Institute for Immunology, Basel, Switzerland,
  • 1987-1990 Research Associate, Department of Immunology, Faculty of Medicine, University of Tokyo,
  • 1990-1995 Scientific member, Basel Institute for Immunology, Basel, Switzerland,
  • 1995-2000 Head, Department of Immunology, The Tokyo Metropolitan Institute of Medical Science,
  • 2000- Professor and Chairman, Department of Immune Regulation, Tokyo Medical and Dental University, Graduate School,
  • PhD., 1984.,

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Academic Society Affiliations 【 display / non-display 】

  • Japanese Society for Immunology

  • Japanese Society of Allergology

  • The Molecular Biology Society of Japan

  • Japanese Cancer Association

  • Japanese Society of Hematology

  • The American Association of Immunologists

  • The American Association of Immunologists

  • Japanese Society of Hematology

  • Japanese Cancer Association

  • The Molecular Biology Society of Japan

  • Japanese Society for Immunology

  • Japanese Society of Allergology

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Academic Activity 【 display / non-display 】

  • Japanese Society for Immunology Board member
  • Japanese Society of Allergology Board of representatives
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Research Areas 【 display / non-display 】

  • Immunology

  • Cell biology

  • Connective tissue disease and allergy

  • Connective tissue disease and allergy

  • Cell biology

  • Immunology

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Research Theme 【 display / non-display 】

  • Genetic origins and pathogenesis of primary immunodeficiencies

  • Roles of basophils in protective immunity, immune regulation and allergy

  • Cellular and molecular basis of chronic allergic inflammation

  • Molecular mechanisms for regulation of lymphocyte development

  • Physiological and pathological roles of basophils, 2019.04 - 2022.03

  • Previously-unappreciated roles for basophils in health and disease, 2015.05 - 2019.03

  • Roles of basophils in protective immunity, immune regulation and allergy

  • Molecular mechanisms for regulation of lymphocyte development

  • Genetic origins and pathogenesis of primary immunodeficiencies

  • Cellular and molecular basis of chronic allergic inflammation

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Published Papers & Misc 【 display / non-display 】

  1. Miyake K, Ito J, Takahashi K, Nakabayashi J, Brombacher F, Shichino S, Yoshikawa S, Miyake S, Karasuyama H. Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model. Nature communications. 2024.02; 15 (1): 1666. ( PubMed, DOI )

  2. Leyva-Castillo JM, Vega-Mendoza D, Strakosha M, Deng L, Choi S, Miyake K, Karasuyama H, Chiu IM, Phipatanakul W, Geha RS. Basophils are important for development of allergic skin inflammation. The Journal of allergy and clinical immunology. 2024.02; ( PubMed, DOI )

  3. Nagashima N, Ugajin T, Miyake K, Walls AF, Namiki T, Yokozeki H, Karasuyama H, Okiyama N. Cutaneous basophil infiltration in atopic dermatitis is associated with abundant epidermal infiltration of helper T cells: A preliminary retrospective study. The Journal of dermatology. 2024.01; 51 (1): 130-134. ( PubMed, DOI )

  4. Strakosha M, Vega-Mendoza D, Kane J, Jain A, Sun L, Rockowitz S, Elkins M, Miyake K, Chou J, Karasuyama H, Geha RS, Leyva-Castillo JM. Basophils Play a Protective Role in the Recovery of Skin Barrier Function from Mechanical Injury in Mice. The Journal of investigative dermatology. 2024.01; ( PubMed, DOI )

  5. LaMarche NM, Hegde S, Park MD, Maier BB, Troncoso L, Le Berichel J, Hamon P, Belabed M, Mattiuz R, Hennequin C, Chin T, Reid AM, Reyes-Torres I, Nemeth E, Zhang R, Olson OC, Doroshow DB, Rohs NC, Gomez JE, Veluswamy R, Hall N, Venturini N, Ginhoux F, Liu Z, Buckup M, Figueiredo I, Roudko V, Miyake K, Karasuyama H, Gonzalez-Kozlova E, Gnjatic S, Passegué E, Kim-Schulze S, Brown BD, Hirsch FR, Kim BS, Marron TU, Merad M. An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature. 2024.01; 625 (7993): 166-174. ( PubMed, DOI )

  6. Takahashi K, Miyake K, Ito J, Shimamura H, Suenaga T, Karasuyama H, Ohashi K. Topical Application of a PDE4 Inhibitor Ameliorates Atopic Dermatitis through Inhibition of Basophil IL-4 Production. The Journal of investigative dermatology. 2023.10; ( PubMed, DOI )

  7. Miyake K, Ito J, Nakabayashi J, Shichino S, Ishiwata K, Karasuyama H. Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils. Nature communications. 2023.05; 14 (1): 2694. ( PubMed, DOI )

  8. Pellefigues C, Karasuyama H. Editorial: The fundamental biology of basophils in health and disease. Frontiers in immunology. 2023; 14 1292279. ( PubMed, DOI )

  9. Hashimoto T, Yokozeki H, Karasuyama H, Satoh T. IL-31-generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin. The Journal of allergy and clinical immunology. 2022.11; 151 (3): 737-746.e6. ( PubMed, DOI )

  10. Inaba K, Higashiyama M, Watanabe C, Tomioka A, Ito S, Tanemoto R, Mizoguchi A, Nishii S, Wada A, Sugihara N, Hanawa Y, Horiuchi K, Akita Y, Okada Y, Kurihara C, Narimatsu K, Komoto S, Tomita K, Karasuyama H, Satoh T, Hokari R. Basophils play a proinflammatory role in oxazolone-induced chronic intestinal inflammation. Journal of gastroenterology and hepatology. 2022.07; 37 (9): 1768-1775. ( PubMed, DOI )

  11. Miyake K, Ito J, Karasuyama H. Role of Basophils in a Broad Spectrum of Disorders. Frontiers in immunology. 2022; 13 902494. ( PubMed, DOI )

  12. Tchen J, Simon Q, Chapart L, Pellefigues C, Karasuyama H, Miyake K, Blank U, Benhamou M, Daugas E, Charles N. CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a Nonredundant Role in Lupus-Like Disease Development. Frontiers in immunology. 2022; 13 900532. ( PubMed, DOI )

  13. van der Vlist M, Raoof R, Willemen HLDM, Prado J, Versteeg S, Martin Gil C, Vos M, Lokhorst RE, Pasterkamp RJ, Kojima T, Karasuyama H, Khoury-Hanold W, Meyaard L, Eijkelkamp N. Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain. Neuron. 2021.12; 110 (4): 613-+. ( PubMed, DOI )

  14. Karasuyama Hajime, Shibata Sho, Yoshikawa Soichiro, Miyake Kensuke. 免疫系において軽視されてきた非主流派の好塩基球はついに脚光を浴びる場所にやってきた(Basophils, a neglected minority in the immune system, have come into the limelight at last) International Immunology. 2021.12; 33 (12): 809-813. ( ichushi )

  15. Leyva-Castillo JM, Das M, Kane J, Strakosha M, Singh S, Wong DSH, Horswill AR, Karasuyama H, Brombacher F, Miller LS, Geha RS. Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection. JCI insight. 2021.11; 6 (21): ( PubMed, DOI )

  16. Miyake Kensuke, Karasuyama Hajime. The Role of Trogocytosis in the Modulation of Immune Cell Functions CELLS. 2021.05; 10 (5): ( PubMed, DOI )

  17. Nagaishi T, Watabe T, Kotake K, Kumazawa T, Aida T, Tanaka K, Ono R, Ishino F, Usami T, Miura T, Hirakata S, Kawasaki H, Tsugawa N, Yamada D, Hirayama K, Yoshikawa S, Karasuyama H, Okamoto R, Watanabe M, Blumberg RS, Adachi T. Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum. Gut. 2021.05; 71 (3): 487-496. ( PubMed, DOI )

  18. Karasuyama H, Shibata S, Yoshikawa S, Miyake K. Basophils, a neglected minority in the immune system, have come into the limelight at last. International immunology. 2021.05; 33 (12): 809-813. ( PubMed, DOI )

  19. Wanet Anais, Bassal Mahmoud A., Patel Sweta B., Marchi Francisco, Mariani Samanta A., Ahmed Nouraiz, Zhang Haoran, Borchiellini Marta, Chen Sisi, Zhang Junyan, Di Ruscio Annalisa, Miyake Kensuke, Tsai Mindy, Paranjape Anuya, Park Shin-Young, Karasuyama Hajime, Schroeder Timm, Dzierzak Elaine, Galli Stephen J., Tenen Daniel G., Welner Robert S.. E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates SCIENCE IMMUNOLOGY. 2021.02; 6 (56): eaba0178. ( PubMed, DOI )

  20. Yoshikawa Soichiro, Miyake Kensuke, Kamiya Atsunori, Karasuyama Hajime. The role of basophils in acquired protective immunity to tick infestation PARASITE IMMUNOLOGY. 2020.11; 43 (5): e12804. ( PubMed, DOI )

  21. Miyake Kensuke, Shibata Sho, Yoshikawa Soichiro, Karasuyama Hajime. Basophils and their effector molecules in allergic disorders ALLERGY. 2020.11; 76 (6): 1693-1706. ( PubMed, DOI )

  22. Karasuyama Hajime, Miyake Kensuke, Yoshikawa Soichiro. Immunobiology of Acquired Resistance to Ticks FRONTIERS IN IMMUNOLOGY. 2020.10; 11 601504. ( PubMed, DOI )

  23. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. Identification of two distinct subpopulations among basophils in the bone marrow(和訳中) アレルギー. 2020.10; 69 (臨時増刊号): 133. ( ichushi )

  24. Aihara Yoshiko, Fukuda Yota, Takizawa Akiyoshi, Osakabe Naomi, Aida Tomomi, Tanaka Kohichi, Yoshikawa Soichiro, Karasuyama Hajime, Adachi Takahiro. 生体内イメージングを用いた腸管における機械的ストレス媒介Ca2+シグナル伝達の可視化(Visualization of mechanical stress-mediated Ca2+ signaling in the gut using intravital imaging) Bioscience of Microbiota, Food and Health. 2020.10; 39 (4): 209-218. ( ichushi )

  25. Miyake Kensuke, Ito Junya, Takahashi Kazufusa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. Regulation of immune cells　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation(和訳中) アレルギー. 2020.10; 69 (臨時増刊号): 91. ( ichushi )

  26. Yang Yue, Nagai Shigenori, Kang Siwen, Xia Yulong, Kawano Yohei, Miyake Kensuke, Karasuyama Hajime, Azuma Miyuki. 反復抗原塗布後に舌下粘膜に現れたCD206+マクロファージの免疫寛容原性(Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting) International Immunology. 2020.08; 32 (8): 509-518. ( ichushi )

  27. Yang Y, Nagai S, Kang S, Xia Y, Kawano Y, Miyake K, Karasuyama H, Azuma M. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting. International immunology. 2020.07; 32 (8): 509-518. ( PubMed, DOI )

  28. Yamanishi Yoshinori, Mogi Kotone, Takahashi Kazufusa, Miyake Kensuke, Yoshikawa Soichiro, Karasuyama Hajime. Skin-infiltrating basophils promote atopic dermatitis-like inflammation via IL-4 production in mice ALLERGY. 2020.05; 75 (10): 2613-2622. ( PubMed, DOI )

  29. Nishimura Yuya, Fukuda Yota, Okonogi Toya, Yoshikawa Soichiro, Karasuyama Hajime, Osakabe Naomi, Ikegaya Yuji, Sasaki Takuya, Adachi Takahiro. Dual real-time in vivo monitoring system of the brain-gut axis BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020.04; 524 (2): 340-345. ( PubMed, DOI )

  30. Lin Yu-Hsien, Tahara-Hanaoka Satoko, Nagai Kei, Yoshikawa Soichiro, Kubo Masato, Shibayama Shiro, Karasuyama Hajime, Shibuya Akira. マウスにおける好塩基球上のAllergin-1による経口アレルゲン誘導アナフィラキシーの選択的抑制(Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice) International Immunology. 2020.03; 32 (3): 213-219. ( ichushi )

  31. Aihara Yoshiko, Fukuda Yota, Takizawa Akiyoshi, Osakabe Naomi, Aida Tomomi, Tanaka Kohichi, Yoshikawa Soichiro, Karasuyama Hajime, Adachi Takahiro. Visualization of mechanical stress-mediated Ca2+ signaling in the gut using intravital imaging BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH. 2020; 39 (4): 209-218. ( PubMed, DOI )

  32. Lin YH, Tahara-Hanaoka S, Nagai K, Yoshikawa S, Kubo M, Shibayama S, Karasuyama H, Shibuya A. Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice. International Immunology. 2019.12; 32 (3): 213-219. ( PubMed, DOI )

  33. Kashiwakura J, Ando T, Karasuyama H, Kubo M, Matsumoto K, Matsuda T, Kawakami T. The basophil-IL-4-mast cell axis is required for food allergy. Allergy. 2019.10; 74 (10): 1992-1996. ( PubMed, DOI )

  34. Yoshikawa S., Oh-hora M., Hashimoto R., Miyake K., Adachi T., Kawano Y., Yamanishi Y., Kamiya A., Karasuyama H.. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated basophils EUROPEAN JOURNAL OF IMMUNOLOGY. 2019.10; 49 584-585.

  35. Adachi Takahiro, Yoshikawa Soichiro, Tezuka Hiroyuki, Tsuji Noriko M., Ohteki Toshiaki, Karasuyama Hajime, Kumazawa Toshihiko. プロポリスは免疫細胞におけるCa2+シグナル伝達を誘導する(Propolis induces Ca2+ signaling in immune cells) Bioscience of Microbiota, Food and Health. 2019.10; 38 (4): 141-149. ( ichushi )

  36. Hashimoto T, Satoh T, Karasuyama H, Yokozeki H. Amphiregulin from Basophils Amplifies Basophil-Mediated Chronic Skin Inflammation. Journal of Investigative Dermatology. 2019.08; 139 (8): 1834-1837.e2. ( PubMed, DOI )

  37. Balam S, Schiechl-Brachner G, Buchtler S, Halbritter D, Schmidbauer K, Talke Y, Neumayer S, Salewski NJ, Winter F, Karasuyama H, Yamanishi Y, Renner K, Geissler EK, Mack M. IL-3 Triggers Chronic Rejection of Cardiac Allografts by Activation of Infiltrating Basophils. Journal of Immunology. 2019.06; 202 (12): 3514-3523. ( PubMed, DOI )

  38. Yoshikawa Soichiro, Oh-hora Masatsugu, Hashimoto Ryota, Nagao Toshihisa, Peters Louis, Egawa Mayumi, Ohta Takuya, Miyake Kensuke, Adachi Takahiro, Kawano Yohei, Yamanishi Yoshinori, Karasuyama Hajime. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils SCIENCE SIGNALING. 2019.04; 12 (576): ( PubMed, DOI )

  39. Piliponsky AM, Shubin NJ, Lahiri AK, Truong P, Clauson M, Niino K, Tsuha AL, Nedospasov SA, Karasuyama H, Reber LL, Tsai M, Mukai K, Galli SJ. Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice. Nature Immunology. 2019.02; 20 (2): 129-140. ( PubMed, DOI )

  40. Nagao T, Yamanishi Y, Miyake K, Teranishi M, Takahashi S, Yoshikawa S, Kawano Y, Karasuyama H. Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. International immunology. 2019.02; 31 (1): 41-49. ( PubMed, DOI )

  41. Nagao Toshihisa, Yamanishi Yoshinori, Miyake Kensuke, Teranishi Mio, Takahashi Saori, Yoshikawa Soichiro, Kawano Yohei, Karasuyama Hajime. マウスにて好塩基球媒介性アレルギー誘発相において、蛋白質の凝集によって蛋白質がアレルゲン化する(Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice) International Immunology. 2019.01; 31 (1): 41-49. ( ichushi )

  42. Adachi T, Yoshikawa S, Tezuka H, Tsuji NM, Ohteki T, Karasuyama H, Kumazawa T. Propolis induces Ca2+ signaling in immune cells. Bioscience of Microbiota, Food and Health. 2019; 38 (4): 141-149. ( PubMed, DOI )

  43. Tateishi T., Shibata S., Karasuyama H., Miyazaki Y.. Basophil Depletion Leads to Promotion of the Lung Fibrosis in Bleomycin-Mouse Model AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019; 199

  44. Sho Shibata, Kensuke Miyake, Tomoya Tateishi, Soichiro Yoshikawa, Yoshinori Yamanishi, Yasunari Miyazaki, Naohiko Inase, Hajime Karasuyama. Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages. Proc. Natl. Acad. Sci. U.S.A.. 2018.12; 115 (51): 13057-13062. ( PubMed, DOI )

  45. Hajime Karasuyama, Yuya Tabakawa, Takuya Ohta, Takeshi Wada, Soichiro Yoshikawa. Crucial Role for Basophils in Acquired Protective Immunity to Tick Infestation. Front Physiol. 2018.12; 9 1769. ( PubMed, DOI )

  46. Karasuyama Hajime, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Yamanishi Yoshinori. How do basophils contribute to T(h)2 cell differentiation and allergic responses? INTERNATIONAL IMMUNOLOGY. 2018.09; 30 (9): 391-396. ( PubMed, DOI )

  47. Karasuyama Hajime, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Yamanishi Yoshinori. 好塩基球はいかにしてTh2細胞分化およびアレルギー反応に寄与するか?(How do basophils contribute to Th2 cell differentiation and allergic responses?) International Immunology. 2018.09; 30 (9): 391-396. ( ichushi )

  48. Hajime Karasuyama, Kensuke Miyake, Soichiro Yoshikawa, Yoshinori Yamanishi. Multifaceted roles of basophils in health and disease. J. Allergy Clin. Immunol.. 2018.08; 142 (2): 370-380. ( PubMed, DOI )

  49. Yuya Tabakawa, Takuya Ohta, Soichiro Yoshikawa, Elisabeth J Robinson, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Kensuke Miyake, Yoshinori Yamanishi, Hiroshi Ohtsu, Takahiro Adachi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama. Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice. Front Immunol. 2018.07; 9 1540. ( PubMed, DOI )

  50. Yohei Kawano, Georg Petkau, Christina Stehle, Pawel Durek, Gitta Anne Heinz, Kousuke Tanimoto, Hajime Karasuyama, Mir-Farzin Mashreghi, Chiara Romagnani, Fritz Melchers. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood. 2018.05; 131 (18): 2026-2035. ( PubMed, DOI )

  51. Christophe Pellefigues, Barbara Dema, Yasmine Lamri, Fanny Saidoune, Nathalie Chavarot, Charlotte Lohéac, Emeline Pacreau, Michael Dussiot, Caroline Bidault, Florian Marquet, Mathieu Jablonski, Jonathan M Chemouny, Fanny Jouan, Antoine Dossier, Marie-Paule Chauveheid, Delphine Gobert, Thomas Papo, Hajime Karasuyama, Karim Sacré, Eric Daugas, Nicolas Charles. Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs. Nat Commun. 2018.02; 9 (1): 725. ( PubMed, DOI )

  52. Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe. B cell activation in the cecal patches during the development of an experimental colitis model. Biochem. Biophys. Res. Commun.. 2018.02; 496 (2): 367-373. ( PubMed, DOI )

  53. Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Sato Shingo, Karasuyama Hajime. Allergy: Allergic dermatitis, food allergy and allergic conjunctivitis Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 2-G. ( ichushi )

  54. Kojima Toshiyuki, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. Mucosal-Skin Immunity(2) Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-F. ( ichushi )

  55. Miyake Kensuke, Shiozawa Nozomu, Nagao Toshihisa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. Granulocyte & Mast cells Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells(DCs)(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-H. ( ichushi )

  56. Takahiro Adachi, Yoshikawa Soichiro, Karasuyama Hajime. B cell development and function Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-E. ( ichushi )

  57. Karasuyama Hajime. Allergy: state-of-the-art Emerging roles of basophils in allergic inflammation and immune regulation(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): S1-4. ( ichushi )

  58. SHIBATA Sho, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime. Allergy: Lower airway allergic inflammation Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP-12 production in a mouse model of COPD(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 1-A. ( ichushi )

  59. Takuya Ohta, Soichiro Yoshikawa, Yuya Tabakawa, Kayoko Yamaji, Kenji Ishiwata, Hiroshi Shitara, Choji Taya, Masatsugu Oh-Hora, Yohei Kawano, Kensuke Miyake, Yoshinori Yamanishi, Hiromichi Yonekawa, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama. Skin CD4+ Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites. Front Immunol. 2017.10; 8 1348. ( PubMed, DOI )

  60. Barbara Dema, Yasmine Lamri, Christophe Pellefigues, Emeline Pacreau, Fanny Saidoune, Caroline Bidault, Hajime Karasuyama, Karim Sacré, Eric Daugas, Nicolas Charles. Basophils contribute to pristane-induced Lupus-like nephritis model. Sci Rep. 2017.08; 7 (1): 7969. ( PubMed, DOI )

  61. Yoshinori Yamanishi, Kensuke Miyake, Misako Iki, Hidemitsu Tsutsui, Hajime Karasuyama. Recent advances in understanding basophil-mediated Th2 immune responses. Immunol. Rev.. 2017.07; 278 (1): 237-245. ( PubMed, DOI )

  62. Kensuke Miyake, Hajime Karasuyama. Emerging roles of basophils in allergic inflammation. Allergol Int. 2017.07; 66 (3): 382-391. ( PubMed, DOI )

  63. Sumika Toyama, Naoko Okada, Akio Matsuda, Hideaki Morita, Hirohisa Saito, Takao Fujisawa, Susumu Nakae, Hajime Karasuyama, Kenji Matsumoto. Human eosinophils constitutively express a unique serine protease, PRSS33. Allergol Int. 2017.07; 66 (3): 463-471. ( PubMed, DOI )

  64. Tomoyuki Bando, Setsuko Fujita, Naoko Nagano, Soichiro Yoshikawa, Yoshinori Yamanishi, Masashi Minami, Hajime Karasuyama. Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils. Biochem Biophys Rep. 2017.07; 10 82-87. ( PubMed, DOI )

  65. Miyake Kensuke, Karasuyama Hajime. アレルギー性炎症における好塩基球の新たな役割(Beyond Th2, More than ILC2　Emerging roles of basophils in allergic inflammation) Allergology International. 2017.07; 66 (3): 382-391. ( ichushi )

  66. Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Sato Shingo, Yoshikawa Soichiro, Karasuyama Hajime. IgE介在性慢性アレルギー性炎症において好塩基球性トリプターゼmMCP-11は重要な役割を果たす(Basophil tryptase mMCP-11 plays a crucial role in the IgE-mediated chronic allergic inflammation) アレルギー. 2017.05; 66 (4-5): 520. ( ichushi )

  67. Kaori Mukai, Hajime Karasuyama, Kenji Kabashima, Masato Kubo, Stephen J Galli. Differences in the Importance of Mast Cells, Basophils, IgE, and IgG versus That of CD4+ T Cells and ILC2 Cells in Primary and Secondary Immunity to Strongyloides venezuelensis. Infect. Immun.. 2017.04; 85 (5): e00053-17. ( PubMed, DOI )

  68. Bianca Balbino, Riccardo Sibilano, Philipp Starkl, Thomas Marichal, Nicolas Gaudenzio, Hajime Karasuyama, Pierre Bruhns, Mindy Tsai, Laurent L Reber, Stephen J Galli. Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis. J. Allergy Clin. Immunol.. 2017.02; 139 (2): 584-596.e10. ( PubMed, DOI )

  69. Hidemitsu Tsutsui, Yoshinori Yamanishi, Hiromi Ohtsuka, Shingo Sato, Soichiro Yoshikawa, Hajime Karasuyama. The Basophil-specific Protease mMCP-8 Provokes an Inflammatory Response in the Skin with Microvascular Hyperpermeability and Leukocyte Infiltration. J. Biol. Chem.. 2017.01; 292 (3): 1061-1067. ( PubMed, DOI )

  70. Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils. Proc. Natl. Acad. Sci. U.S.A.. 2017.01; 114 (5): 1111-1116. ( PubMed, DOI )

  71. Iki, M., Tanaka, K., Deki, H. Fujimaki, M., Sato, S., Yoshikawa, S., Yamanishi, Y., Karasuyama, K.. Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation in mice. Blood. 2016.12; 128 (25): 2909-2918. ( PubMed, DOI )

  72. Venturelli, N., Lexmond, W. S., Ohsaki, A., Nurko, S., Karasuyama, H., Fiebiger, E., Oyoshi, M. K.. Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33-basophil axis in mice. J. Allergy Clin. Immunol.. 2016.11; 138 (5): 1367-1380.e5. ( PubMed, DOI )

  73. Kojima, T., Tsuchiya, K., Ikemizu, S., Yoshikawa, S., Yamanishi, Y., Watanabe, M., Karasuyama, H.. Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R. Sci Rep. 2016.11; 6 36457. ( PubMed, DOI )

  74. Horiguchi, K., Yoshikawa, S., Saito, A., Haddad, S., Ohta, T., Miyake, K., Yamanishi, Y., Karasuyama, H.. Real-time imaging of mast cell degranulation in vitro and in vivo. Biochem. Biophys. Res. Commun.. 2016.10; 479 (3): 517-522. ( PubMed, DOI )

  75. Yamanishi, Y., Karasuyama, H.. Basophils and mast cells in immunity and inflammation. Semin Immunopathol. 2016.09; 38 (5): 535-537. ( PubMed, DOI )

  76. Yamanishi, Y., Karasuyama, H.. Basophil-derived IL-4 plays versatile roles in immunity. Semin Immunopathol. 2016.09; 38 (5): 615-622. ( PubMed, DOI )

  77. Schiechl, G., Hermann, F.J., Rodriguez Gomez, M., Kutzi, S., Schmidbauer, K., Talke, Y., Neumayer, S., Goebel, N., Renner, K., Brühl, H., Karasuyama, H., Obata-Ninomiya, K., K Utpatel, K., Evert, M., Hirt, S.W., Geissler, E.K., Fichtner-Feigl, S., Mack, M.. Basophils Trigger Fibroblast Activation in Cardiac Allograft Fibrosis Development. Am. J. Transplant.. 2016.09; 16 (9): 2574-2588. ( PubMed, DOI )

  78. Baba, T., Tanabe, Y., Yoshikawa, S., Yamanishi, Y., Morishita, S., Komatsu, N., Karasuyama, H., Hirao, A., Mukaida N.. MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice. Blood. 2016.05; 127 (21): 2607-2617. ( PubMed, DOI )

  79. Yoshikawa, S., Usami, T., Kikuta, J., Ishii, M., Sasano, T., Sugiyama, K., Furukawa, T., Nakasho, E., Takayanagi, H., Tedder, T. F., Karasuyama, H., Miyawaki, A., Adachi, T.. Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Sci Rep. 2016.01; 6 18738. ( PubMed, DOI )

  80. Adachi, T., Kakuta, S., Aihara, Y., Kamiya, T., Watanabe, Y., Osakabe, N., Hazato, N., Miyawaki, A., Yoshikawa, S., Usami, T., Karasuyama, H., Kimoto-Nira, H., Hirayama, K., M Tsuji, N.. Visualization of Probiotic-Mediated Ca(2+) Signaling in Intestinal Epithelial Cells In Vivo. Front Immunol. 2016; 7 601. ( PubMed, DOI )

  81. LiHua, L., Yoshikawa, S., Ohta, T., Horiguchi, K., Kawano, Y., Ohtsu, H., Yamanishi, Y., and Karasuyama, H.. Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens. Biochem. Biophys. Res. Commun. . 2015.11; 467 (6 (1)): 70-75. ( PubMed )

  82. Morita, H., Arae, K., Unno, H., Nambu, A, Oboki, K., Ohno, T., Matsuda, A., Toyama, S., Miyauchi, K., Yamaguchi, S., Narushima, S., Kajiwara, N., Iikura, M., Suto, H., McKenzie, A., Takahashi, T., Karasuyama, H., Okumara, K., Azuma, M., Galli, SJ., Moro, K., Akdis, C., Koyasu, S., Kubo, M., Sudo, K., Saito, H., Matsumoto, K., and Nakae, S.. An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers. Immunity. 2015.07; 43 (1): 175-186. ( PubMed, DOI )

  83. Tsai, S.H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada Y., Takeda A., Yoshikawa, S., Obata-Ninomiya, K., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H., and Takeda, K.. The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity. 2015.02; 42 (2): 279-293. ( PubMed, DOI )

  84. Hajime Karasuyama, Yoshinori Yamanishi. Basophils have emerged as a key player in immunity. Curr. Opin. Immunol.. 2014.12; 31 1-7. ( PubMed, DOI )

  85. Laurent L Reber, Thomas Marichal, Jeremy Sokolove, Philipp Starkl, Nicolas Gaudenzio, Yoichiro Iwakura, Hajime Karasuyama, Lawrence B Schwartz, William H Robinson, Mindy Tsai, Stephen J Galli. Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice. Arthritis and Rheumatology (Hoboken, N.J.). 2014.10; 66 (10): 2881-2891. ( PubMed, DOI )

  86. Nadja Bakocevic, Carla Claser, Soichiro Yoshikawa, Leigh Ann Jones, Samantha Chew, Chi Ching Goh, Benoit Malleret, Anis Larbi, Florent Ginhoux, Maria Curotto de Lafaille, Hajime Karasuyama, Laurent Renia, Lai Guan Ng. CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections. Eur. J. Immunol.. 2014.06; 44 (6): 1823-1834. ( PubMed, DOI )

  87. Mahbubul Morshed, Ruslan Hlushchuk, Dagmar Simon, Andrew F Walls, Kazushige Obata-Ninomiya, Hajime Karasuyama, Valentin Djonov, Alexander Eggel, Thomas Kaufmann, Hans-Uwe Simon, Shida Yousefi. NADPH oxidase-independent formation of extracellular DNA traps by basophils. J. Immunol.. 2014.06; 192 (11): 5314-5323. ( PubMed, DOI )

  88. Karasuyama H.. Basophils. Global Atlas of Allergy. 2014; 56-57.

  89. Egawa, M., Mukai, K., and Karasuyama, H.. Basophil-derived IL-4 induces the differentiation of inflammatory monocytes into M2-type macrophages to dampen allergic inflammation. Allergic diseases: from mechanisms to cures.. 2014; 59-62.

  90. Shiraishi Y, Jia Y, Domenico J, Joetham A, Karasuyama H, Takeda K, Gelfand E.W. Sequential engagement of FcεRI on mast cells and basophil histamine H4 receptor and FcεRI in allergic rhinitis Journal of Immunology. 2013.01; 190 (2): 539-548. ( PubMed, DOI )

  91. Ogawa H, Mukai K, Kawano Y, Minegishi Y, Karasuyama H. Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-α on macrophages through the autocrine action of IL-6. Biochemical and biophysical research communications. 2012.03; 420 (1): 114-118. ( PubMed, DOI )

  92. Ishikawa Y, Kobayashi K, Yamamoto M, Nakata K, Takagawa T, Funada Y, Kotani Y, Karasuyama H, Yoshida M, Nishimura Y. Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells. Respiratory research. 2011.04; 12 42. ( PubMed, DOI )

  93. Takai T, Karasuyama H. The study of allergy by Japanese researchers: a historical perspective. Int Immunol. 2009.12; 21 (12): 1311-1316. ( PubMed, DOI )

  94. Ugajin T, Kojima T, Mukai K, Obata K, Kawano Y, Minegishi Y, Eishi Y, Yokozeki H, Karasuyama H. Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells. J Leukoc Biol. 2009.08; ( PubMed, DOI )

  95. Minegishi Y, Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Karasuyama H. Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J Exp Med. 2009.06; 206 (6): 1291-1301. ( PubMed, DOI )

  96. Karasuyama H. [An exciting new era of basophil research: newly discovered roles for basophils in acute and chronic allergic reactions] Arerugi. 2009.06; 58 (6): 635-637. ( PubMed )

  97. Mukai K, Obata K, Tsujimura Y, Karasuyama H. New insights into the roles for basophils in acute and chronic allergy. Allergol Int. 2009.03; 58 (1): 11-19. ( PubMed, DOI )

  98. Belkina NV, Liu Y, Hao JJ, Karasuyama H, Shaw S. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Proc Natl Acad Sci U S A. 2009.03; 106 (12): 4707-4712. ( PubMed, DOI )

  99. Khodoun M, Strait R, Orekov T, Hogan S, Karasuyama H, Herbert DR, Kohl J, Finkelman FD. Peanuts can contribute to anaphylactic shock by activating complement. J Allergy Clin Immunol. 2009.02; 123 (2): 342-351. ( PubMed, DOI )

  100. Minegishi Y, Karasuyama H. Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency. Int Immunol. 2009.02; 21 (2): 105-112. ( PubMed, DOI )

  101. Hida S, Yamasaki S, Sakamoto Y, Takamoto M, Obata K, Takai T, Karasuyama H, Sugane K, Saito T, Taki S. Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat Immunol. 2009.02; 10 (2): 214-222. ( PubMed, DOI )

  102. Karasuyama H, Mukai K, Tsujimura Y, Obata K. Newly discovered roles for basophils: a neglected minority gains new respect. Nat Rev Immunol. 2009.01; 9 (1): 9-13. ( PubMed, DOI )

  103. Yoshikawa S, Kawano Y, Minegishi Y, Karasuyama H. The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver. Int Immunol. 2009.01; 21 (1): 43-52. ( PubMed, DOI )

  104. Takada T, Shitara H, Matsuoka K, Kojima E, Ishii R, Kikkawa Y, Taya C, Karasuyama H, Kohno K, Yonekawa H. A novel hairless mouse model on an atopic dermatitis-prone genetic background generated by receptor-mediated transgenesis. Transgenic Res. 2008.12; 17 (6): 1155-1162. ( PubMed, DOI )

  105. Watanabe M, Satoh T, Yamamoto Y, Kanai Y, Karasuyama H, Yokozeki H. Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils. J Immunol. 2008.10; 181 (8): 5653-5659. ( PubMed )

  106. Minegishi Y, Karasuyama H. Genetic origins of hyper-IgE syndrome. Curr Allergy Asthma Rep. 2008.09; 8 (5): 386-391. ( PubMed )

  107. Tsujimura Y, Obata K, Mukai K, Shindou H, Yoshida M, Nishikado H, Kawano Y, Minegishi Y, Shimizu T, Karasuyama H. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity. 2008.04; 28 (4): 581-589. ( PubMed, DOI )

  108. Yasuda T, Sanjo H, Pages G, Kawano Y, Karasuyama H, Pouyssegur J, Ogata M, Kurosaki T. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity. 2008.04; 28 (4): 499-508. ( PubMed, DOI )

  109. Minegishi Y, Karasuyama H. Hyperimmunoglobulin E syndrome and tyrosine kinase 2 deficiency. Curr Opin Allergy Clin Immunol. 2007.12; 7 (6): 506-509. ( PubMed, DOI )

  110. Kojima T, Obata K, Mukai K, Sato S, Takai T, Minegishi Y, Karasuyama H. Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. J Immunol. 2007.11; 179 (10): 7093-7100. ( PubMed )

  111. Obata K, Mukai K, Tsujimura Y, Ishiwata K, Kawano Y, Minegishi Y, Watanabe N, Karasuyama H. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood. 2007.08; 110 (3): 913-920. ( PubMed, DOI )

  112. Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature. 2007.08; 448 (7157): 1058-1062. ( PubMed, DOI )

  113. Ochiai K, Katoh Y, Ikura T, Hoshikawa Y, Noda T, Karasuyama H, Tashiro S, Muto A, Igarashi K. Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J Biol Chem. 2006.12; 281 (50): 38226-38234. ( PubMed, DOI )

  114. Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity. 2006.11; 25 (5): 745-755. ( PubMed, DOI )

  115. Yamamoto M, Hayashi K, Nojima T, Matsuzaki Y, Kawano Y, Karasuyama H, Goitsuka R, Kitamura D. BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement. Blood. 2006.10; 108 (8): 2703-2711. ( PubMed, DOI )

  116. Kawano Y, Yoshikawa S, Minegishi Y, Karasuyama H. Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals. J Immunol. 2006.08; 177 (4): 2242-2249. ( PubMed )

  117. Kubota T, Mukai K, Minegishi Y, Karasuyama H. Different stabilities of the structurally related receptors for IgE and IgG on the cell surface are determined by length of the stalk region in their alpha-chains. J Immunol. 2006.06; 176 (11): 7008-7014. ( PubMed )

  118. Mukai K, Matsuoka K, Taya C, Suzuki H, Yokozeki H, Nishioka K, Hirokawa K, Etori M, Yamashita M, Kubota T, Minegishi Y, Yonekawa H, Karasuyama H. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity. 2005.08; 23 (2): 191-202. ( PubMed, DOI )

  119. Kawano Y, Yoshikawa S, Minegishi Y, Karasuyama H. Selection of stereotyped VH81X-{micro}H chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells. Int Immunol. 2005.07; 17 (7): 857-867. ( PubMed, DOI )

  120. Jimi E, Phillips RJ, Rincon M, Voll R, Karasuyama H, Flavell R, Ghosh S. Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. Int Immunol. 2005.06; 17 (6): 815-825. ( PubMed, DOI )

  121. Omata N, Ohshima Y, Yasutomi M, Yamada A, Karasuyama H, Mayumi M. Ovalbumin-specific IgE modulates ovalbumin-specific T-cell response after repetitive oral antigen administration. J Allergy Clin Immunol. 2005.04; 115 (4): 822-827. ( PubMed, DOI )

  122. Toyama-Sorimachi N, Omatsu Y, Onoda A, Tsujimura Y, Iyoda T, Kikuchi-Maki A, Sorimachi H, Dohi T, Taki S, Inaba K, Karasuyama H. Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner. J Immunol. 2005.04; 174 (8): 4621-4629. ( PubMed )

  123. Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H, Miyake K, Yamanashi Y. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J Exp Med. 2005.02; 201 (3): 333-339. ( PubMed, DOI )

  124. Taguchi T, Kiyokawa N, Takenouch H, Matsui J, Tang WR, Nakajima H, Suzuki K, Shiozawa Y, Saito M, Katagiri YU, Takahashi T, Karasuyama H, Matsuo Y, Okita H, Fujimoto J. Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells. Immunology. 2004.08; 112 (4): 575-582. ( PubMed, DOI )

  125. Kiyokawa N, Sekino T, Matsui T, Takenouchi H, Mimori K, Tang WR, Matsui J, Taguchi T, Katagiri YU, Okita H, Matsuo Y, Karasuyama H, Fujimoto J. Diagnostic importance of CD179a/b as markers of precursor B-cell lymphoblastic lymphoma. Mod Pathol. 2004.04; 17 (4): 423-429. ( PubMed, DOI )

  126. Toyama-Sorimachi N, Tsujimura Y, Maruya M, Onoda A, Kubota T, Koyasu S, Inaba K, Karasuyama H. Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture. Proc Natl Acad Sci U S A. 2004.01; 101 (4): 1016-1021. ( PubMed, DOI )

  127. Maezawa Y, Nakajima H, Seto Y, Suto A, Kumano K, Kubo S, Karasuyama H, Saito Y, Iwamoto I. IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways. Clin Exp Immunol. 2004.01; 135 (1): 12-18. ( PubMed )

  128. Minami J, Eishi Y, Ishige Y, Kobayashi I, Ishige I, Kobayashi D, Ando N, Uchida K, Ikeda S, Sorimachi N, Karasuyama H, Takemura T, Takizawa T, Koike M. Pulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of Propionibacterium acnes. J Med Dent Sci. 2003.12; 50 (4): 265-274. ( PubMed )

  129. Kawashima I, Yoshida Y, Taya C, Shitara H, Yonekawa H, Karasuyama H, Tada N, Furukawa K, Tai T. Expansion of natural killer cells in mice transgenic for IgM antibody to ganglioside GD2: demonstration of prolonged survival after challenge with syngeneic tumor cells. Int J Oncol. 2003.08; 23 (2): 381-388. ( PubMed )

  130. Terauchi M, Koi H, Hayano C, Toyama-Sorimachi N, Karasuyama H, Yamanashi Y, Aso T, Shirakata M. Placental extravillous cytotrophoblasts persistently express class I major histocompatibility complex molecules after human cytomegalovirus infection. J Virol. 2003.08; 77 (15): 8187-8195. ( PubMed )

  131. Maezawa Y, Nakajima H, Kumano K, Kubo S, Karasuyama H, Iwamoto I. Role of IgE in Th2 cell-mediated allergic airway inflammation. Int Arch Allergy Immunol. 2003.06; 131 Suppl 1 2-6. ( PubMed, DOI )

  132. Saijo K, Schmedt C, Su IH, Karasuyama H, Lowell CA, Reth M, Adachi T, Patke A, Santana A, Tarakhovsky A. Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol. 2003.03; 4 (3): 274-279. ( PubMed, DOI )

  133. Tsuchiya K, Kawano Y, Kojima T, Nagata K, Takao T, Okada M, Shinohara H, Maki K, Toyama-Sorimachi N, Miyasaka N, Watanabe M, Karasuyama H. Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS Lett. 2003.02; 537 (1-3): 203-209. ( PubMed )

  134. Taguchi T, Kiyokawa N, Mimori K, Suzuki T, Sekino T, Nakajima H, Saito M, Katagiri YU, Matsuo N, Matsuo Y, Karasuyama H, Fujimoto J. Pre-B cell antigen receptor-mediated signal inhibits CD24-induced apoptosis in human pre-B cells. J Immunol. 2003.01; 170 (1): 252-260. ( PubMed )

  135. Kubo S, Nakayama T, Matsuoka K, Yonekawa H, Karasuyama H. Long term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE. J Immunol. 2003.01; 170 (2): 775-780. ( PubMed )

  136. Sato E, Hirahara K, Wada Y, Yoshitomi T, Azuma T, Matsuoka K, Kubo S, Taya C, Yonekawa H, Karasuyama H, Shiraishi A. Chronic inflammation of the skin can be induced in IgE transgenic mice by means of a single challenge of multivalent antigen. J Allergy Clin Immunol. 2003.01; 111 (1): 143-148. ( PubMed )

  137. Wang YH, Stephan RP, Scheffold A, Kunkel D, Karasuyama H, Radbruch A, Cooper MD. Differential surrogate light chain expression governs B-cell differentiation. Blood. 2002.04; 99 (7): 2459-2467. ( PubMed )

  138. Stephan RP, Elgavish E, Karasuyama H, Kubagawa H, Cooper MD. Analysis of VpreB expression during B lineage differentiation in lambda5-deficient mice. J Immunol. 2001.10; 167 (7): 3734-3739. ( PubMed )

  139. Kubo S, Matsuoka K, Taya C, Kitamura F, Takai T, Yonekawa H, Karasuyama H. Drastic up-regulation of Fcepsilonri on mast cells is induced by IgE binding through stabilization and accumulation of Fcepsilonri on the cell surface. J Immunol. 2001.09; 167 (6): 3427-3434. ( PubMed )

  140. Kinoshita T, Nagata K, Sorimachi N, Karasuyama H, Sekiguchi T, Miyajima A. Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment. Exp Hematol. 2001.09; 29 (9): 1091-1097. ( PubMed )

  141. Agematsu K, Nagumo H, Hokibara S, Mori T, Wada T, Yachie A, Kanegane H, Miyawaki T, Sugita K, Karasuyama H, Komiyama A. Complete arrest from pro- to pre-B cells in a case of B cell-negative severe combined immunodeficiency (SCID) without recombinase activating gene (RAG) mutations. Clin Exp Immunol. 2001.06; 124 (3): 461-464. ( PubMed )

  142. Kouro T, Nagata K, Takaki S, Nisitani S, Hirano M, Wahl MI, Witte ON, Karasuyama H, Takatsu K. Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition. Int Immunol. 2001.04; 13 (4): 485-493. ( PubMed )

  143. Toyama-Sorimachi N, Taguchi Y, Yagita H, Kitamura F, Kawasaki A, Koyasu S, Karasuyama H. Mouse CD94 participates in Qa-1-mediated self recognition by NK cells and delivers inhibitory signals independent of Ly-49. J Immunol. 2001.03; 166 (6): 3771-3779. ( PubMed )

  144. Kohara Y, Tanabe K, Matsuoka K, Kanda N, Matsuda H, Karasuyama H, Yonekawa H. A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9. Immunogenetics. 2001.02; 53 (1): 15-21. ( PubMed )

  145. Shuichi Kubo, Kunie Matsuoka, Choji Taya, Fujiko Kitmura, Hiromichi Yonekawa, Hajime Karasuyama. IgE stabilizes its high affinity receptor (FcεRI) on mast cells in vitro and ex vivo Activating and inhibitory immunoglobulin-like receptors. 2001; 183-188.

  146. Ohnishi K, Shimizu T, Karasuyama H, Melchers F. The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain. J Biol Chem. 2000.10; 275 (40): 31134-31144. ( PubMed, DOI )

  147. Nomura K, Kanegane H, Karasuyama H, Tsukada S, Agematsu K, Murakami G, Sakazume S, Sako M, Tanaka R, Kuniya Y, Komeno T, Ishihara S, Hayashi K, Kishimoto T, Miyawaki T. Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway. Blood. 2000.07; 96 (2): 610-617. ( PubMed )

  148. Nagaoka H, Takahashi Y, Hayashi R, Nakamura T, Ishii K, Matsuda J, Ogura A, Shirakata Y, Karasuyama H, Sudo T, Nishikawa S, Tsubata T, Mizuochi T, Asano T, Sakano H, Takemori T. Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage. J Exp Med. 2000.07; 192 (2): 171-182. ( PubMed )

  149. Ellinger-Ziegelbauer H, Karasuyama H, Yamada E, Tsujikawa K, Todokoro K, Nishida E. Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells. Genes Cells. 2000.06; 5 (6): 491-498. ( PubMed )

  150. Donohoe ME, Beck-Engeser GB, Lonberg N, Karasuyama H, Riley RL, Jack HM, Blomberg BB. Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype. J Immunol. 2000.05; 164 (10): 5269-5276. ( PubMed )

  151. Tagawa K, Taya C, Hayashi Y, Nakagawa M, Ono Y, Fukuda R, Karasuyama H, Toyama-Sorimachi N, Katsui Y, Hata S, Ishiura S, Nonaka I, Seyama Y, Arahata K, Yonekawa H, Sorimachi H, Suzuki K. Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A. Hum Mol Genet. 2000.05; 9 (9): 1393-1402. ( PubMed )

  152. Maki K, Nagata K, Kitamura F, Takemori T, Karasuyama H. Immunoglobulin beta signaling regulates locus accessibility for ordered immunoglobulin gene rearrangements. J Exp Med. 2000.04; 191 (8): 1333-1340. ( PubMed )

  153. Endo J, Toyama-Sorimachi N, Taya C, Kuramochi-Miyagawa S, Nagata K, Kuida K, Takashi T, Yonekawa H, Yoshizawa Y, Miyasaka N, Karasuyama H. Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. FEBS Lett. 2000.02; 468 (2-3): 234-238. ( PubMed )

  154. Bosma GC, Chang Y, Karasuyama H, Bosma MJ. Differential effect of an Ig mu transgene on development of pre-B cells in fetal and adult SCID mice. Proc Natl Acad Sci U S A. 1999.10; 96 (21): 11952-11957. ( PubMed )

  155. Miyazaki T, Kato I, Takeshita S, Karasuyama H, Kudo A. Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines. Int Immunol. 1999.08; 11 (8): 1195-1202. ( PubMed )

  156. Matsuoka K, Taya C, Kubo S, Toyama-Sorimachi N, Kitamura F, Ra C, Yonekawa H, Karasuyama H. Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivo. Int Immunol. 1999.06; 11 (6): 987-994. ( PubMed )

  157. Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H. Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. Immunogenetics. 1999.05; 49 (5): 369-375. ( PubMed )

  158. Tsuganezawa K, Kiyokawa N, Matsuo Y, Kitamura F, Toyama-Sorimachi N, Kuida K, Fujimoto J, Karasuyama H. Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human pre-B-cell receptor. Blood. 1998.12; 92 (11): 4317-4324. ( PubMed )

  159. Muto A, Hoshino H, Madisen L, Yanai N, Obinata M, Karasuyama H, Hayashi N, Nakauchi H, Yamamoto M, Groudine M, Igarashi K. Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer. EMBO J. 1998.10; 17 (19): 5734-5743. ( PubMed, DOI )

  160. Meffre E, Papavasiliou F, Cohen P, de Bouteiller O, Bell D, Karasuyama H, Schiff C, Banchereau J, Liu YJ, Nussenzweig MC. Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells. J Exp Med. 1998.08; 188 (4): 765-772. ( PubMed )

  161. Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998.08; 94 (3): 325-337. ( PubMed )

  162. Koyama M, Ishihara K, Karasuyama H, Cordell JL, Iwamoto A, Nakamura T. CD79 alpha/CD79 beta heterodimers are expressed on pro-B cell surfaces without associated mu heavy chain. Int Immunol. 1997.11; 9 (11): 1767-1772. ( PubMed )

  163. Nagata K, Nakamura T, Kitamura F, Kuramochi S, Taki S, Campbell KS, Karasuyama H. The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity. 1997.10; 7 (4): 559-570. ( PubMed )

  164. Kuramochi S, Moriguchi T, Kuida K, Endo J, Semba K, Nishida E, Karasuyama H. LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. J Biol Chem. 1997.09; 272 (36): 22679-22684. ( PubMed )

  165. Emoto K, Toyama-Sorimachi N, Karasuyama H, Inoue K, Umeda M. Exposure of phosphatidylethanolamine on the surface of apoptotic cells. Exp Cell Res. 1997.05; 232 (2): 430-434. ( PubMed, DOI )

  166. Karasuyama H, Nakamura T, Nagata K, Kuramochi T, Kitamura F, Kuida K. The roles of preB cell receptor in early B cell development and its signal transduction. Immunol Cell Biol. 1997.04; 75 (2): 209-216. ( PubMed, DOI )

  167. Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 1996.11; 384 (6607): 368-372. ( PubMed, DOI )

  168. Maki K, Sunaga S, Komagata Y, Kodaira Y, Mabuchi A, Karasuyama H, Yokomuro K, Miyazaki JI, Ikuta K. Interleukin 7 receptor-deficient mice lack gammadelta T cells. Proc Natl Acad Sci U S A. 1996.07; 93 (14): 7172-7177. ( PubMed )

  169. Karasuyama H, Rolink A, Melchers F. Surrogate light chain in B cell development. Adv Immunol. 1996; 63 1-41. ( PubMed )

  170. Sawai H, Yamasaki N, Shigeta M, Komori S, Karasuyama H, Koyama K, Isojima S. Direct production of the Fab fragment derived from the sperm immobilizing antibody using polymerase chain reaction and cDNA expression vectors. Am J Reprod Immunol. 1995.07; 34 (1): 26-34. ( PubMed )

  171. Rolink A, Ghia P, Grawunder U, Haasner D, Karasuyama H, Kalberer C, Winkler T, Melchers F. In-vitro analyses of mechanisms of B-cell development. Semin Immunol. 1995.06; 7 (3): 155-167. ( PubMed )

  172. Melchers F, Rolink A, Grawunder U, Winkler TH, Karasuyama H, Ghia P, Andersson J. Positive and negative selection events during B lymphopoiesis. Curr Opin Immunol. 1995.04; 7 (2): 214-227. ( PubMed )

  173. Winkler TH, Rolink A, Melchers F, Karasuyama H. Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface. Eur J Immunol. 1995.02; 25 (2): 446-450. ( PubMed )

  174. Rolink A, Grawunder U, Winkler TH, Karasuyama H, Melchers F. IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int Immunol. 1994.08; 6 (8): 1257-1264. ( PubMed )

  175. Karasuyama H, Rolink A, Shinkai Y, Young F, Alt FW, Melchers F. The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell. 1994.04; 77 (1): 133-143. ( PubMed )

  176. Rolink A, Karasuyama H, Haasner D, Grawunder U, Martensson IL, Kudo A, Melchers F. Two pathways of B-lymphocyte development in mouse bone marrow and the roles of surrogate L chain in this development. Immunol Rev. 1994.02; 137 185-201. ( PubMed )

  177. Melchers F, Haasner D, Grawunder U, Kalberer C, Karasuyama H, Winkler T, Rolink AG. Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu Rev Immunol. 1994; 12 209-225. ( PubMed, DOI )

  178. Karasuyama H, Rolink A, Melchers F. A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines. J Exp Med. 1993.08; 178 (2): 469-478. ( PubMed )

  179. Rolink A, Karasuyama H, Grawunder U, Haasner D, Kudo A, Melchers F. B cell development in mice with a defective lambda 5 gene. Eur J Immunol. 1993.06; 23 (6): 1284-1288. ( PubMed )

  180. Sawai H, Yamasaki N, Komori S, Karasuyama H, Isojima S. Stable production of recombinant human sperm immobilizing antibody using cDNA expression vectors. Am J Reprod Immunol. 1993.03; 29 (2): 100-108. ( PubMed )

  181. Melchers F, Karasuyama H, Haasner D, Bauer S, Kudo A, Sakaguchi N, Jameson B, Rolink A. The surrogate light chain in B-cell development. Immunol Today. 1993.02; 14 (2): 60-68. ( PubMed )

  182. Uemura N, Ozawa K, Tojo A, Takahashi K, Okano A, Karasuyama H, Tani K, Asano S. Acquisition of interleukin-3 independence in FDC-P2 cells after transfection with the activated c-H-ras gene using a bovine papillomavirus-based plasmid vector. Blood. 1992.12; 80 (12): 3198-3204. ( PubMed )

  183. Melchers F, Haasner D, Karasuyama H, Reininger L, Rolink A. Progenitor and precursor B lymphocytes of mice. Proliferation and differentiation in vitro and population, differentiation and turnover in SCID mice in vivo of normal and abnormal cells. Curr Top Microbiol Immunol. 1992; 182 3-12. ( PubMed )

  184. Yamamura Y, Kotani M, Chowdhury MI, Yamamoto N, Yamaguchi K, Karasuyama H, Katsura Y, Miyasaka M. Infection of human CD4+ rabbit cells with HIV-1: the possibility of the rabbit as a model for HIV-1 infection. Int Immunol. 1991.11; 3 (11): 1183-1187. ( PubMed )

  185. Golumbek PT, Lazenby AJ, Levitsky HI, Jaffee LM, Karasuyama H, Baker M, Pardoll DM. Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science. 1991.11; 254 (5032): 713-716. ( PubMed )

  186. Tanaka T, Tsudo M, Karasuyama H, Kitamura F, Kono T, Hatakeyama M, Taniguchi T, Miyasaka M. A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells. J Immunol. 1991.10; 147 (7): 2222-2228. ( PubMed )

  187. Rolink A, Kudo A, Karasuyama H, Kikuchi Y, Melchers F. Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. EMBO J. 1991.02; 10 (2): 327-336. ( PubMed )

  188. Miyajima H, Hirano T, Hirose S, Karasuyama H, Okumura K, Ovary Z. Suppression by IL-2 of IgE production by B cells stimulated by IL-4. J Immunol. 1991.01; 146 (2): 457-462. ( PubMed )

  189. Tanaka T, Tsudo M, Karasuyama H, Toyama N, Hatakeyama M, Taniguchi T, Miyasaka M. Signal transduction through the human IL-2 receptor beta-chain expressed in IL-6-dependent mouse B cell hybridoma. Int Immunol. 1991.01; 3 (1): 105-108. ( PubMed )

  190. Yamamura Y, Kotani M, Tsudo M, Karasuyama H, Seto A, Miyasaka M. IL-2 receptors on rabbit T-cell lines and their transfectants expressing the human IL-2 receptor alpha chain. Immunology. 1990.12; 71 (4): 502-507. ( PubMed )

  191. Karasuyama H, Kudo A, Melchers F. The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain. J Exp Med. 1990.09; 172 (3): 969-972. ( PubMed )

  192. Tsudo M, Karasuyama H, Kitamura F, Tanaka T, Kubo S, Yamamura Y, Tamatani T, Hatakeyama M, Taniguchi T, Miyasaka M. The IL-2 receptor beta-chain (p70). Ligand binding ability of the cDNA-encoding membrane and secreted forms. J Immunol. 1990.07; 145 (2): 599-606. ( PubMed )

  193. Tohyama N, Karasuyama H, Tada T. Growth autonomy and tumorigenicity of interleukin 6-dependent B cells transfected with interleukin 6 cDNA. J Exp Med. 1990.02; 171 (2): 389-400. ( PubMed )

  194. Fearon ER, Pardoll DM, Itaya T, Golumbek P, Levitsky HI, Simons JW, Karasuyama H, Vogelstein B, Frost P. Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell. 1990.02; 60 (3): 397-403. ( PubMed )

  195. Sano K, Kishimoto H, Karasuyama H, Asano Y, Tada T. Cell division-associated expression of an epitope, KH17, on early developing thymocytes. Int Immunol. 1990; 2 (8): 725-733. ( PubMed )

  196. Tsudo M, Karasuyama H, Kitamura F, Nagasaka Y, Tanaka T, Miyasaka M. Reconstitution of a functional IL-2 receptor by the beta-chain cDNA. A newly acquired receptor transduces negative signal. J Immunol. 1989.12; 143 (12): 4039-4043. ( PubMed )

  197. Sato T, Kohno S, Kobayashi H, Yoshida K, Karasuyama H, Tabata T. [Prosthetic application of a new measuring instrument of the dynamic periodontal function] Nihon Hotetsu Shika Gakkai Zasshi. 1989.10; 33 (5): 1202-1211. ( PubMed )

  198. Tani K, Ozawa K, Ogura H, Takahashi T, Okano A, Watari K, Matsudaira T, Tajika K, Karasuyama H, Nagata S, et al.. Implantation of fibroblasts transfected with human granulocyte colony-stimulating factor cDNA into mice as a model of cytokine-supplement gene therapy. Blood. 1989.09; 74 (4): 1274-1280. ( PubMed )

  199. Tonouchi N, Miwa K, Karasuyama H, Matsui H. Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells. Biochem Biophys Res Commun. 1989.09; 163 (2): 1056-1062. ( PubMed )

  200. Yagita H, Nakamura T, Karasuyama H, Okumura K. Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells. Proc Natl Acad Sci U S A. 1989.01; 86 (2): 645-649. ( PubMed )

  201. Karasuyama H, Tohyama N, Tada T. Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J Exp Med. 1989.01; 169 (1): 13-25. ( PubMed )

  202. Melchers F, Bauer SR, Berger C, Karasuyama H, Kudo A, Rolink A, Sakaguchi N, Strasser A, Thalmann P. Precursor B lymphocytes--specific monoclonal antibodies and genes. Adv Exp Med Biol. 1989; 254 87-93. ( PubMed )

  203. Karasuyama H. [Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using high-copy cDNA expression vectors] Tanpakushitsu Kakusan Koso. 1988.11; 33 (14): 2527-2532. ( PubMed )

  204. Karasuyama H, Rolink A, Melchers F. Recombinant interleukin 2 or 5, but not 3 or 4, induces maturation of resting mouse B lymphocytes and propagates proliferation of activated B cell blasts. J Exp Med. 1988.04; 167 (4): 1377-1390. ( PubMed )

  205. Kohno S, Karasuyama H, Yoshida K, Kobayashi H. [A study on the causative mechanism of occlusal interference on the balancing side] Nihon Hotetsu Shika Gakkai Zasshi. 1988.04; 32 (2): 505-513. ( PubMed )

  206. Karasuyama H, Melchers F. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur J Immunol. 1988.01; 18 (1): 97-104. ( PubMed )

  207. Asano Y, Nakayama T, Kubo M, Fujisawa I, Karasuyama H, Singer A, Hodes RJ, Tada T. Analysis of two distinct B cell activation pathways mediated by a monoclonal T helper cell. II. T helper cell secretion of interleukin 4 selectively inhibits antigen-specific B cell activation by cognate, but not noncognate, interactions with T cells. J Immunol. 1988.01; 140 (2): 419-426. ( PubMed )

  208. Palacios R, Karasuyama H, Rolink A. Ly1+ PRO-B lymphocyte clones. Phenotype, growth requirements and differentiation in vitro and in vivo. EMBO J. 1987.12; 6 (12): 3687-3693. ( PubMed )

  209. Staerz UD, Karasuyama H, Garner AM. Cytotoxic T lymphocytes against a soluble protein. Nature. 1987.10; 329 (6138): 449-451. ( PubMed, DOI )

  210. Lernhardt W, Karasuyama H, Rolink A, Melchers F. Control of the cell cycle of murine B lymphocytes: the nature of alpha- and beta-B-cell growth factors and of B-cell maturation factors. Immunol Rev. 1987.10; 99 241-262. ( PubMed )

  211. Karasuyama H, Kim M, Okumura K, Tada T. Heterogeneity of Igh-linked allotypic determinants expressed on functional T cell subsets as detected by monoclonal antibodies. Eur J Immunol. 1984.05; 14 (5): 413-420. ( PubMed )

  212. Abe R, Karasuyama H, Yagi J, Tada T. Regulation of allotype-linked NPb idiotype by an idiotype-positive soluble factor derived from a T cell hybridoma. Coupling of the circuit regulation to the network concept. Int Arch Allergy Appl Immunol. 1984; 74 (4): 289-296. ( PubMed )

  213. Tada T, Okumura K, Yamada S, Kitahara T, Karasuyama H, Ochi A, Yamauchi K. Regulation of tumor-specific immune response by T cell products. Prog Clin Biol Res. 1983; 132B 345-351. ( PubMed )

  214. Tada T, Okumura K, Miyatani S, Ochi A, Nakauchi H, Karasuyama H. Restricting elements in the immunological circuitry: the role of I region-controlled determinants. Ann N Y Acad Sci. 1983; 418 189-197. ( PubMed )

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Conference Activities & Talks 【 display / non-display 】

  1. Ito Junya, Miyake Kensuke, Takahashi Kazufusa, Shichino Shigeyuki, Karasuyama Hajime. Dendritic cells and macrophages-2: Myeloid cell linage and their differentiation(Transcriptomic and functional analyses uncover an immature subpopulation of basophils in the bone marrow and FoxO1 as a transcription factor involved in the regulation of basophil responsiveness). 日本免疫学会総会・学術集会記録 2022.11.01

  2. Miyake Kensuke, Ito Junya, Takahashi Kazufusa, Nakabayashi Jun, Shichino Shigeyuki, Karasuyama Hajime. Mucosal-Skin Immunity(M2 macrophages generated in the termination phase of skin allergic inflammation display high efferocytic capacity and promote resolution of inflammation). 日本免疫学会総会・学術集会記録 2022.11.01

  3. Takahashi Kazufusa, Miyake Kensuke, Ito Junya, Shimamura Hinano, Karasuyama Hajime. Molecular and cellular diversity of allergic diseases(II)(Difamilast, a selective phosphodiesterase 4 inhibitor, suppresses IL-4 production by basophils and ameliorates atopic dermatitis in a murine model). 日本免疫学会総会・学術集会記録 2022.11.01

  4. Urakami Hitoshi, Fujita Yuki, Nagao Kei, Miyake Kensuke, Karasuyama Hajime, Miyake Sachiko, Yoshikawa Soichiro. Molecular and cellular diversity of allergic disease(Chronic psychological stress exacerbates IgE-dependent chronic allergic inflammation by suppressing M2-macrophage-mediated efferocytosis). 日本免疫学会総会・学術集会記録 2022.11.01

  5. Urakami Hitoshi, Fujita Yuki, Komura Ayaka, Nagao Kei, Matsui Keigo, Hino Shota, Miyake Kensuke, Karasuyama Hajime, Yoshikawa Soichiro, Kamiya Atsunori, Morizane Shin. Psychological stress exacerbates skin allergic inflammation by dysfunction of anti-inflammatory M2 macrophages via β2-adrenergic receptor(タイトル和訳中). 日本研究皮膚科学会年次学術大会・総会プログラム 2022.10.01

  6. Nagashima Natsumi, Ugajin Tsukasa, Miyake Kensuke, Karasuyama Hajime, Namiki Takeshi, Okiyama Naoko. The clinical and histological characteristics of 'basophil-high' atopic dermatitis(タイトル和訳中). 日本研究皮膚科学会年次学術大会・総会プログラム 2022.10.01

  7. Nagashima Natsumi, Ugajin Tsukasa, Miyake Kensuke, Karasuyama Hajime, Namiki Takeshi, Okiyama Naoko. "好塩基球の多い"アトピー性皮膚炎の臨床的および組織学的特徴(The clinical and histological characteristics of 'basophil-high' atopic dermatitis). 日本研究皮膚科学会年次学術大会・総会プログラム 2022.10.01

  8. Nagashima Natsumi, Ugajin Tsukasa, Miyake Kensuke, Karasuyama Hajime, Namiki Takeshi, Okiyama Naoko. "好塩基球の多い"アトピー性皮膚炎の臨床的および組織学的特徴(The clinical and histological characteristics of 'basophil-high' atopic dermatitis). 日本研究皮膚科学会年次学術大会・総会プログラム 2022.10.01

  9. Ma Ni, Kishimoto Izumi, Kambe Naotomo, Nakashima Chisa, Otsuka Atsushi, Miyake Kensuke, Karasuyama Hajime, Tanizaki Hideaki. Basophil dynamics during the active phase of urticaria using an Oxazolone-induced contact hypersensitivity mouse model(和訳中). 日本免疫学会総会・学術集会記録 2021.11.01

  10. Takahashi Kazufusa, Miyake Kensuke, Karasuyama Hajime. Sphingosine kinase 1 contributes to IgE-dependent basophil activation and the development of basophil-dependent delayed-onset skin allergic inflammation(和訳中). 日本免疫学会総会・学術集会記録 2021.11.01

  11. Miyake Kensuke, Ito Junya, Takahashi Kazufusa, Nakabayashi Jun, Shichino Shigeyuki, Yoshikawa Soichiro, Karasuyama Hajime. Single-cell RNA-seq analysis provides novel insights into the mechanism underlying the termination of basophil-elicited allergic inflammation in the skin(和訳中). 日本免疫学会総会・学術集会記録 2021.11.01

  12. Ito Junya, Miyake Kensuke, Nakabayashi Jun, Shichino Shigeyuki, Karasuyama Hajime. Single-cell RNA-seq analysis identified a novel subpopulation of basophils with immature phenotypes and unique functionality(和訳中). 日本免疫学会総会・学術集会記録 2021.11.01

  13. Urakami Hitoshi, Fujita Yuki, Komura Ayaka, Nagao Kei, Okutani Ruriko, Miyake Kensuke, Karasuyama Hajime, Yoshikawa Soichiro. Chronic psychological stress exacerbates IgE-dependent chronic allergic inflammation via sympathetic nerve(和訳中). 日本免疫学会総会・学術集会記録 2021.11.01

  14. Miyake Kensuke, Takahashi Kazufusa, Ito Junya, Nakabayashi Jun, Shichino Shigeyuki, Yoshikawa Soichiro, Karasuyama Hajime. Basophils promote the generation of highly phagocytic M2 macrophages which dampen excess inflammation at the resolution phase of allergic inflammation(和訳中). 日本免疫学会総会・学術集会記録 2021.11.01

  15. Takahashi Kazufusa, Miyake Kensuke, Karasuyama Hajime. IgE依存性好塩基球活性化と好塩基球依存性遅延発症型皮膚アレルギー性炎症発症へのスフィンゴシンキナーゼ1の寄与(Sphingosine kinase 1 contributes to IgE-dependent basophil activation and the development of basophil-dependent delayed-onset skin allergic inflammation). 日本免疫学会総会・学術集会記録 2021.11.01

  16. Ito Junya, Miyake Kensuke, Nakabayashi Jun, Shichino Shigeyuki, Karasuyama Hajime. シングルセルRNA-seq解析により同定した未成熟な表現型とユニークな機能性を持つ好塩基球の新規subpopulation(Single-cell RNA-seq analysis identified a novel subpopulation of basophils with immature phenotypes and unique functionality). 日本免疫学会総会・学術集会記録 2021.11.01

  17. Ma Ni, Kishimoto Izumi, Kambe Naotomo, Nakashima Chisa, Otsuka Atsushi, Miyake Kensuke, Karasuyama Hajime, Tanizaki Hideaki. オキサゾロン誘発接触過敏症モデルマウスを用いた蕁麻疹の活動期における好塩基球動態(Basophil dynamics during the active phase of urticaria using an Oxazolone-induced contact hypersensitivity mouse model). 日本免疫学会総会・学術集会記録 2021.11.01

  18. Miyake Kensuke, Ito Junya, Takahashi Kazufusa, Nakabayashi Jun, Shichino Shigeyuki, Yoshikawa Soichiro, Karasuyama Hajime. シングルセルRNA-seq解析により明らかとなった好塩基球が誘発するアレルギー性炎症の皮膚における終息メカニズム(Single-cell RNA-seq analysis provides novel insights into the mechanism underlying the termination of basophil-elicited allergic inflammation in the skin). 日本免疫学会総会・学術集会記録 2021.11.01

  19. Urakami Hitoshi, Fujita Yuki, Komura Ayaka, Nagao Kei, Okutani Ruriko, Miyake Kensuke, Karasuyama Hajime, Yoshikawa Soichiro. 慢性的な心理的ストレスは交感神経を介してIgE依存性慢性アレルギー性炎症を増悪させる(Chronic psychological stress exacerbates IgE-dependent chronic allergic inflammation via sympathetic nerve). 日本免疫学会総会・学術集会記録 2021.11.01

  20. Miyake Kensuke, Takahashi Kazufusa, Ito Junya, Nakabayashi Jun, Shichino Shigeyuki, Yoshikawa Soichiro, Karasuyama Hajime. 好塩基球はアレルギー炎症の収束期における過剰な炎症を抑制する貪食能の高いM2マクロファージの生成を促進する(Basophils promote the generation of highly phagocytic M2 macrophages which dampen excess inflammation at the resolution phase of allergic inflammation). 日本免疫学会総会・学術集会記録 2021.11.01

  21. Miyake Kensuke, Takahashi Kazufusa, Ito Junya, Nakabayashi Jun, Shichino Shigeyuki, Yoshikawa Soichiro, Karasuyama Hajime. 好塩基球に由来するIL-4はM2マクロファージの生成を誘発しアポトーシス細胞のefferocytic clearanceを介して皮膚の慢性アレルギー性炎症を緩和する(Basophil-derived IL-4 induces the generation of M2 macrophages which dampen skin chronic allergic inflammation via the efferocytic clearance of dead cells). アレルギー 2021.08.01

  22. Kensuke Miyake, Hajime Karasuyama. Basophils present antigens to T cells via trogocytosis-mediated acquisition of MHC class II. 第43回日本分子生物学会年会(MBSJ2020) 2020.12.04

  23. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. 骨髄中の好塩基球における二つの異なる亜集団の同定(Identification of two distinct subpopulations among basophils in the bone marrow). アレルギー 2020.10.01

  24. Miyake Kensuke, Ito Junya, Takahashi Kazufusa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 免疫細胞の制御　活性化した好塩基球によって誘導された単球由来M2様マクロファージが、IL-1αを介したアレルギー性炎症の悪化を抑制する(Regulation of immune cells　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation). アレルギー 2020.10.01

  25. Miyake Kensuke, Ito Junya, Takahashi Kazufusa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 免疫細胞の制御　活性化した好塩基球によって誘導された単球由来M2様マクロファージが、IL-1αを介したアレルギー性炎症の悪化を抑制する(Regulation of immune cells　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation). アレルギー 2020.10.01

  26. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. 骨髄中の好塩基球における二つの異なる亜集団の同定(Identification of two distinct subpopulations among basophils in the bone marrow). アレルギー 2020.10.01

  27. Miyake Kensuke, Ito Junya, Takahashi Kazufusa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 免疫細胞の制御　活性化した好塩基球によって誘導された単球由来M2様マクロファージが、IL-1αを介したアレルギー性炎症の悪化を抑制する(Regulation of immune cells　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation). アレルギー 2020.10.01

  28. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. 骨髄中の好塩基球における二つの異なる亜集団の同定(Identification of two distinct subpopulations among basophils in the bone marrow). アレルギー 2020.10.01

  29. Miyake Kensuke, Ito Junya, Takahashi Kazufusa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 免疫細胞の制御　活性化した好塩基球によって誘導された単球由来M2様マクロファージが、IL-1αを介したアレルギー性炎症の悪化を抑制する(Regulation of immune cells　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation). アレルギー 2020.10.01

  30. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. 骨髄中の好塩基球における二つの異なる亜集団の同定(Identification of two distinct subpopulations among basophils in the bone marrow). アレルギー 2020.10.01

  31. Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation. JSA/WAO Joint Congress 2020 2020.09.01

  32. Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation. JSA/WAO Joint Congress 2020 2020.09

  33. Junya Ito, Kensuke Miyake, Shigeyuki Shichino, Yoshinori Yamanishi, Hajime Karasuyama. Identification of two distinct subpopulations among basophils in the bone marrow. JSA/WAO Joint Congress 2020 2020.09

  34. Takahiro Adachi, Taro Watabe, Takashi Nagaishi, Mamoru Watanabe, Hajime Karasuyama, Soichiro Yoshikawa. IgA-deficiency causes spontaneous enteritis.. The 48th Annual Meeting of the Japanese Society for Immunology 2019.12.13 Hamamatsu（Japan）

  35. Mogi Kotone, Takahashi Kazufusa, Miyake Kensuke, Yoshikawa Soichiro, Karasuyama Hajime, Yamanishi Yoshinori. Allergy-1: skin inflammation　Basophil-derived IL-4 promotes disease progression in a hapten-elicited murine model of atopic dermatitis(和訳中). 日本免疫学会総会・学術集会記録 2019.11.01

  36. Lin Yu-hsien, Tahara-Hanaoka Satoko, Yoshikawa Soichiro, Shibayama Shiro, Karasuyama Hajime, Shibuya Akira. Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Selective suppression of oral allergen-induced anaphylaxis by Allergin-1(和訳中). 日本免疫学会総会・学術集会記録 2019.11.01

  37. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Identification of immature-type basophils that are distinguishable from mature ones in terms of surface phenotype and activation property(和訳中). 日本免疫学会総会・学術集会記録 2019.11.01

  38. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. アレルギー　アナフィラキシー、気道炎症/喘息およびその他(皮膚炎を除く)　細胞表面の表現型と活性化特性から成熟型とは区別可能な未熟型好塩基球の同定(Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Identification of immature-type basophils that are distinguishable from mature ones in terms of surface phenotype and activation property). 日本免疫学会総会・学術集会記録 2019.11.01

  39. Adachi Takahiro, Watabe Taro, Nagaishi Takashi, Watanabe Mamoru, Karasuyama Hajime, Yoshikawa Soichiro. 皮膚-粘膜炎症　IgA欠乏は散発性腸炎を引き起こす(Skin-Mucosal Inflammation　IgA-deficiency causes spontaneous enteritis). 日本免疫学会総会・学術集会記録 2019.11.01

  40. Miyake Kensuke, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. アレルギー　皮膚炎　好塩基球により活性化された単球由来M2様マクロファージはIL-1αを介したアレルギー性炎症の悪化を鈍らす(Allergy-1: skin inflammation　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation). 日本免疫学会総会・学術集会記録 2019.11.01

  41. Mogi Kotone, Takahashi Kazufusa, Miyake Kensuke, Yoshikawa Soichiro, Karasuyama Hajime, Yamanishi Yoshinori. アレルギー　皮膚炎　Hapten誘発性アトピー性皮膚炎モデルマウスにおいて好塩基球由来のIL-4は疾患進行を促進させる(Allergy-1: skin inflammation　Basophil-derived IL-4 promotes disease progression in a hapten-elicited murine model of atopic dermatitis). 日本免疫学会総会・学術集会記録 2019.11.01

  42. Lin Yu-Hsien, Tahara-Hanaoka Satoko, Yoshikawa Soichiro, Shibayama Shiro, Karasuyama Hajime, Shibuya Akira. アレルギー　アナフィラキシー、気道炎症/喘息およびその他(皮膚炎を除く)　経口アレルゲン誘発性アナフィラキシー反応のAllergin-1による選択的抑制(Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Selective suppression of oral allergen-induced anaphylaxis by Allergin-1). 日本免疫学会総会・学術集会記録 2019.11.01

  43. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. アレルギー　アナフィラキシー、気道炎症/喘息およびその他(皮膚炎を除く)　細胞表面の表現型と活性化特性から成熟型とは区別可能な未熟型好塩基球の同定(Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Identification of immature-type basophils that are distinguishable from mature ones in terms of surface phenotype and activation property). 日本免疫学会総会・学術集会記録 2019.11.01

  44. Adachi Takahiro, Watabe Taro, Nagaishi Takashi, Watanabe Mamoru, Karasuyama Hajime, Yoshikawa Soichiro. 皮膚-粘膜炎症　IgA欠乏は散発性腸炎を引き起こす(Skin-Mucosal Inflammation　IgA-deficiency causes spontaneous enteritis). 日本免疫学会総会・学術集会記録 2019.11.01

  45. Miyake Kensuke, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. アレルギー　皮膚炎　好塩基球により活性化された単球由来M2様マクロファージはIL-1αを介したアレルギー性炎症の悪化を鈍らす(Allergy-1: skin inflammation　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation). 日本免疫学会総会・学術集会記録 2019.11.01

  46. Mogi Kotone, Takahashi Kazufusa, Miyake Kensuke, Yoshikawa Soichiro, Karasuyama Hajime, Yamanishi Yoshinori. アレルギー　皮膚炎　Hapten誘発性アトピー性皮膚炎モデルマウスにおいて好塩基球由来のIL-4は疾患進行を促進させる(Allergy-1: skin inflammation　Basophil-derived IL-4 promotes disease progression in a hapten-elicited murine model of atopic dermatitis). 日本免疫学会総会・学術集会記録 2019.11.01

  47. Lin Yu-Hsien, Tahara-Hanaoka Satoko, Yoshikawa Soichiro, Shibayama Shiro, Karasuyama Hajime, Shibuya Akira. アレルギー　アナフィラキシー、気道炎症/喘息およびその他(皮膚炎を除く)　経口アレルゲン誘発性アナフィラキシー反応のAllergin-1による選択的抑制(Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Selective suppression of oral allergen-induced anaphylaxis by Allergin-1). 日本免疫学会総会・学術集会記録 2019.11.01

  48. Adachi Takahiro, Watabe Taro, Nagaishi Takashi, Watanabe Mamoru, Karasuyama Hajime, Yoshikawa Soichiro. 皮膚-粘膜炎症　IgA欠乏は散発性腸炎を引き起こす(Skin-Mucosal Inflammation　IgA-deficiency causes spontaneous enteritis). 日本免疫学会総会・学術集会記録 2019.11.01

  49. Miyake Kensuke, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. アレルギー　皮膚炎　好塩基球により活性化された単球由来M2様マクロファージはIL-1αを介したアレルギー性炎症の悪化を鈍らす(Allergy-1: skin inflammation　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation). 日本免疫学会総会・学術集会記録 2019.11.01

  50. Mogi Kotone, Takahashi Kazufusa, Miyake Kensuke, Yoshikawa Soichiro, Karasuyama Hajime, Yamanishi Yoshinori. アレルギー　皮膚炎　Hapten誘発性アトピー性皮膚炎モデルマウスにおいて好塩基球由来のIL-4は疾患進行を促進させる(Allergy-1: skin inflammation　Basophil-derived IL-4 promotes disease progression in a hapten-elicited murine model of atopic dermatitis). 日本免疫学会総会・学術集会記録 2019.11.01

  51. Lin Yu-Hsien, Tahara-Hanaoka Satoko, Yoshikawa Soichiro, Shibayama Shiro, Karasuyama Hajime, Shibuya Akira. アレルギー　アナフィラキシー、気道炎症/喘息およびその他(皮膚炎を除く)　経口アレルゲン誘発性アナフィラキシー反応のAllergin-1による選択的抑制(Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Selective suppression of oral allergen-induced anaphylaxis by Allergin-1). 日本免疫学会総会・学術集会記録 2019.11.01

  52. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. アレルギー　アナフィラキシー、気道炎症/喘息およびその他(皮膚炎を除く)　細胞表面の表現型と活性化特性から成熟型とは区別可能な未熟型好塩基球の同定(Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Identification of immature-type basophils that are distinguishable from mature ones in terms of surface phenotype and activation property). 日本免疫学会総会・学術集会記録 2019.11.01

  53. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. アレルギー　アナフィラキシー、気道炎症/喘息およびその他(皮膚炎を除く)　細胞表面の表現型と活性化特性から成熟型とは区別可能な未熟型好塩基球の同定(Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Identification of immature-type basophils that are distinguishable from mature ones in terms of surface phenotype and activation property). 日本免疫学会総会・学術集会記録 2019.11.01

  54. Miyake Kensuke, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. アレルギー　皮膚炎　好塩基球により活性化された単球由来M2様マクロファージはIL-1αを介したアレルギー性炎症の悪化を鈍らす(Allergy-1: skin inflammation　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation). 日本免疫学会総会・学術集会記録 2019.11.01

  55. Mogi Kotone, Takahashi Kazufusa, Miyake Kensuke, Yoshikawa Soichiro, Karasuyama Hajime, Yamanishi Yoshinori. アレルギー　皮膚炎　Hapten誘発性アトピー性皮膚炎モデルマウスにおいて好塩基球由来のIL-4は疾患進行を促進させる(Allergy-1: skin inflammation　Basophil-derived IL-4 promotes disease progression in a hapten-elicited murine model of atopic dermatitis). 日本免疫学会総会・学術集会記録 2019.11.01

  56. Lin Yu-Hsien, Tahara-Hanaoka Satoko, Yoshikawa Soichiro, Shibayama Shiro, Karasuyama Hajime, Shibuya Akira. アレルギー　アナフィラキシー、気道炎症/喘息およびその他(皮膚炎を除く)　経口アレルゲン誘発性アナフィラキシー反応のAllergin-1による選択的抑制(Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Selective suppression of oral allergen-induced anaphylaxis by Allergin-1). 日本免疫学会総会・学術集会記録 2019.11.01

  57. Adachi Takahiro, Watabe Taro, Nagaishi Takashi, Watanabe Mamoru, Karasuyama Hajime, Yoshikawa Soichiro. 皮膚-粘膜炎症　IgA欠乏は散発性腸炎を引き起こす(Skin-Mucosal Inflammation　IgA-deficiency causes spontaneous enteritis). 日本免疫学会総会・学術集会記録 2019.11.01

  58. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. アレルギー　アナフィラキシー、気道炎症/喘息およびその他(皮膚炎を除く)　細胞表面の表現型と活性化特性から成熟型とは区別可能な未熟型好塩基球の同定(Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Identification of immature-type basophils that are distinguishable from mature ones in terms of surface phenotype and activation property). 日本免疫学会総会・学術集会記録 2019.11.01

  59. Miyake Kensuke, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. アレルギー　皮膚炎　好塩基球により活性化された単球由来M2様マクロファージはIL-1αを介したアレルギー性炎症の悪化を鈍らす(Allergy-1: skin inflammation　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation). 日本免疫学会総会・学術集会記録 2019.11.01

  60. Mogi Kotone, Takahashi Kazufusa, Miyake Kensuke, Yoshikawa Soichiro, Karasuyama Hajime, Yamanishi Yoshinori. アレルギー　皮膚炎　Hapten誘発性アトピー性皮膚炎モデルマウスにおいて好塩基球由来のIL-4は疾患進行を促進させる(Allergy-1: skin inflammation　Basophil-derived IL-4 promotes disease progression in a hapten-elicited murine model of atopic dermatitis). 日本免疫学会総会・学術集会記録 2019.11.01

  61. Lin Yu-Hsien, Tahara-Hanaoka Satoko, Yoshikawa Soichiro, Shibayama Shiro, Karasuyama Hajime, Shibuya Akira. アレルギー　アナフィラキシー、気道炎症/喘息およびその他(皮膚炎を除く)　経口アレルゲン誘発性アナフィラキシー反応のAllergin-1による選択的抑制(Allergy-2: Anaphylaxis, airway inflammation/asthma and others (except dermtitis)　Selective suppression of oral allergen-induced anaphylaxis by Allergin-1). 日本免疫学会総会・学術集会記録 2019.11.01

  62. Adachi Takahiro, Watabe Taro, Nagaishi Takashi, Watanabe Mamoru, Karasuyama Hajime, Yoshikawa Soichiro. 皮膚-粘膜炎症　IgA欠乏は散発性腸炎を引き起こす(Skin-Mucosal Inflammation　IgA-deficiency causes spontaneous enteritis). 日本免疫学会総会・学術集会記録 2019.11.01

  63. Kensuke Miyake, Ayako Fukui, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Basophils promote monocyte differentiation to M2-like macrophages that display enhanced capacity of allergen clearance. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.11 Fukuoka

  64. Toshihisa Nagao, Yoshinori Yamanishi, Kensuke Miyake, Mio Teranishi, Soichiro Yoshikawa, Yohei Kawano, Hajime Karasuyama. Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.11 Fukuoka

  65. Soichiro Yoshikawa, Yuya Tabakawa, Takuya Ohta, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Yoshinori Yamanishi, Hiroshi Ohtsu, Takahiro Adachi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama. Histamine Released From Skin-Infiltrating Basophils but not mast cells is crucial for acquired tick resistance in mice. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.11 Fukuoka

  66. Kensuke Miyake, Ayako Fukui, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Basophils promote monocyte differentiation to M2-like macrophages that display enhanced capacity of allergen clearance. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.11 Fukuoka

  67. Yohei Kawano, Georg Petkau, Christina Stehle, Pawel Durek, Gitta Anne Heinz, Kousuke Tanimoto, Hajime Karasuyama, Mir-Farzin Mashreghi, Chiara Romagnani, Fritz Melchers. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.10 Fukuoka

  68. Adachi Takahiro, Karasuyama Hajime, Yoshikawa Soichiro. B細胞　疾患におけるB細胞の役割と調節　免疫細胞におけるCa2+シグナル伝達の動態は免疫疾患の素因と前病的状態を予測する(B cells-2:Roles and regulation of B cells in diseases　Kinetics of Ca2+ signaling in immune cells predict predisposition and pre-pathological conditions of the immune diseases). 日本免疫学会総会・学術集会記録 2018.12.01

  69. Nagao Toshihisa, Yamanishi Yoshinori, Miyake Kensuke, Teranishi Mio, Yoshikawa Soichiro, Kawano Yohei, Karasuyama Hajime. 肥満細胞と顆粒球　マウスにおいて凝集は好塩基球媒介性アレルギーの抗原刺激期にアレルゲン蛋白質を産生する(Mast cells & granulocytes　Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice). 日本免疫学会総会・学術集会記録 2018.12.01

  70. Kawano Yohei, Petkau Georg, Stehle Christina, Durek Pawel, Heinz Gitta Anne, Tanimoto Kousuke, Karasuyama Hajime, Mashreghi Mir-Farzin, Romagnani Chiara, Melchers Fritz. 造血と免疫環境　長期増殖型の正常かつ遺伝学的に修正されていないマウスリンパ系共通前駆細胞の安定した系統とクローン(Hematopoiesis and Immune Environment-1　Stable lines and clones of long-term proliferating normal, genetically unmodified murine commonlymphoid progenitors). 日本免疫学会総会・学術集会記録 2018.12.01

  71. Yoshikawa Soichiro, Tabakawa Yuya, Ohta Takuya, Yamaji Kayoko, Ishiwata Kenji, Kawano Yohei, Yamanishi Yoshinori, Ohtsu Hiroshi, Adachi Takahiro, Watanabe Naohiro, Kanuka Hirotaka, Karasuyama Hajime. 肥満細胞と顆粒球　肥満細胞ではなく皮膚浸潤好塩基球から放出されるhistamineはマウスにおいてマダニ抵抗性の獲得に極めて重要である(Mast cells & granulocytes　Histamine released from skin-infiltrating basophils but not mast cells is crucial for acquired tick resistance in mice). 日本免疫学会総会・学術集会記録 2018.12.01

  72. Miyake Kensuke, Fukui Ayako, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 肥満細胞と顆粒球　好塩基球はアレルゲン除去能の増強を示すM2様マクロファージへの単球分化を促進する(Mast cells & granulocytes　Basophils promote monocyte differentiation to M2-like macrophages that display enhanced capacity of allergen clearance). 日本免疫学会総会・学術集会記録 2018.12.01

  73. Hajime Karasuyama. Roles for basophils in Th2 immune responses. The 32nd CIA 2018.10.02 Mallorca, Spain

  74. Hajime Karasuyama. Roles for basophils in Th2 immune responses. The 10th Japanese-German Immunology Workshop 2018.09.08 Ettal, Germany

  75. Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC clas II complexes from dendritic cells (DCs). The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  76. Toshiyuki Kojima, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Novel CD200 hologues iSEC1 and I SEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  77. Tomoyuki Bando, Setsuko Fujita, Naoko Nagano, Soichiro Yoshikawa, Yoshinori Yamanishi, Masashi Minami, Hajime Karasuyama. Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  78. Toshihisa Nagao, Mio Teranishi, Kensuke Miyake, Soichiro Yoshikawa, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama. Sugar modification of carrier protein confers ability on allergen to induce IgE- and basophil-mediated allergic inflammation. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  79. Takuya Ohta, Soichiro Yoshikawa, Kayoko Yamaji, Kenji Ishiwata, Yuya Tabakawa, Yohei Kawano, Yoshinori Yamanishi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama. Skin-resident memory CD4+ T cells play an essential role in acquired tick resistance through IL-3-mediated basophil recruitment. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  80. Yuya Tabakawa, Takuya Ohta, Soichiro Yoshikawa, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Yoshinori Yamanishi, Naohiro Watanabe, Hiroshi Ohtsu, Hirotaka Kanuka, Hajime Karasuyama . Histamine plays a critical role in acquired protective immunity against tick infestation. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  81. Hidemitsu Tsutsui, Yoshinori Yamanishi, Hiromi Ohtsuka, Shingo Sato, Soichiro Yoshikawa, Hajime Karasuyama. The basophil-specific protease mMCP-8 provokes an inflammatory response in the skin with microvascular hyperpermeability and leukocyte infiltration. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  82. Takahiro Adachi, Soichiro Yoshikawa, Hajime Karasuyama. Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  83. Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Naoya Tsugawa, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe. Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  84. Naoya Tsugawa, Takashi Nagaishi, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe. Verification of immunoglobulin A regulation of mucosal microflora and homeostasis. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  85. Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Naoya Tsugawa, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe. Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  86. Naoya Tsugawa, Takashi Nagaishi, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe. Verification of immunoglobulin A regulation of mucosal microflora and homeostasis. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  87. Toshiyuki Kojima, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Novel CD200 hologues iSEC1 and I SEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  88. Takahiro Adachi, Soichiro Yoshikawa, Hajime Karasuyama. Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  89. Tomoyuki Bando, Setsuko Fujita, Naoko Nagano, Soichiro Yoshikawa, Yoshinori Yamanishi, Masashi Minami, Hajime Karasuyama. Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  90. Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC clas II complexes from dendritic cells (DCs). The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

  91. Soichiro Yoshikawa, Masatsugu Oh-hora, Kensuke Miyake, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama. Prolonged Ca2+ influx via STIM2 is essential for cytokine-induced IL-4 production in basophil. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai, Japan

  92. Sho Shibata, Kensuke Miyake, Soichiro Yoshikawa, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama. Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP12 production in a mouse model of COPD. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai, Japan

  93. Hajime Karasuyama. Emerging roles of basophils in allergic inflammation and immune regulation. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai, Japan

  94. Yohei Kawano, Georg Petkau, Christina Stehle, Pawel Durek, Gitta Anne Heinz, Kousuke Tanimoto, Hajime Karasuyama, Mir-Farzin Mashreghi, Chiara Romagnani, Fritz Melchers. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors.. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai, Japan

  95. Hajime Karasuyama. Emerging roles of basophils in allergic inflammation and immune regulation. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai, Japan

  96. SHIBATA Sho, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime. COPDマウスモデルにおいて肺の単球由来マクロファージはMMP-12産生を通して肺気腫の発生に関与する(Allergy: Lower airway allergic inflammation　Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP-12 production in a mouse model of COPD). 日本免疫学会総会・学術集会記録 2017.12.01

  97. Miyake Kensuke, Shiozawa Nozomu, Nagao Toshihisa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 顆粒球及びマスト細胞　好塩基球はトロゴサイトーシスを介して樹状細胞(DC)由来のペプチドMHCクラスII複合体を獲得し抗原を提示する(Granulocyte & Mast cells　Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells(DCs)). 日本免疫学会総会・学術集会記録 2017.12.01

  98. Karasuyama Hajime. アレルギー　最先端　アレルギー性炎症と免疫調節における好塩基球の新たな役割(Allergy: state-of-the-art　Emerging roles of basophils in allergic inflammation and immune regulation). 日本免疫学会総会・学術集会記録 2017.12.01

  99. Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Sato Shingo, Karasuyama Hajime. アレルギー(3)　アレルギー性皮膚炎、食物アレルギー、アレルギー性結膜炎　IgE媒介性遅発性アレルギー性炎症において好塩基性tryptase mMCP-11は極めて重要な役割を果たす(Allergy: Allergic dermatitis, food allergy and allergic conjunctivitis　Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation). 日本免疫学会総会・学術集会記録 2017.12.01

  100. Takahiro Adachi, Yoshikawa Soichiro, Karasuyama Hajime. B細胞の発生と機能　Ca2+バイオセンサーYC3.60導入マウスのリンパ球におけるCa2+シグナルの生体内イメージング(B cell development and function　Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice). 日本免疫学会総会・学術集会記録 2017.12.01

  101. Miyake Kensuke, Shiozawa Nozomu, Nagao Toshihisa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 顆粒球及びマスト細胞　好塩基球はトロゴサイトーシスを介して樹状細胞(DC)由来のペプチドMHCクラスII複合体を獲得し抗原を提示する(Granulocyte & Mast cells　Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells(DCs)). 日本免疫学会総会・学術集会記録 2017.12.01

  102. Kojima Toshiyuki, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 粘膜皮膚免疫(2)　新規CD200相同体のiSEC1とiSEC2は抑制性受容体CD200Rの胃腸分泌型細胞特異的リガンドである(Mucosal-Skin Immunity(2)　Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R). 日本免疫学会総会・学術集会記録 2017.12.01

  103. Takahiro Adachi, Yoshikawa Soichiro, Karasuyama Hajime. B細胞の発生と機能　Ca2+バイオセンサーYC3.60導入マウスのリンパ球におけるCa2+シグナルの生体内イメージング(B cell development and function　Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice). 日本免疫学会総会・学術集会記録 2017.12.01

  104. SHIBATA Sho, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime. COPDマウスモデルにおいて肺の単球由来マクロファージはMMP-12産生を通して肺気腫の発生に関与する(Allergy: Lower airway allergic inflammation　Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP-12 production in a mouse model of COPD). 日本免疫学会総会・学術集会記録 2017.12.01

  105. Miyake Kensuke, Shiozawa Nozomu, Nagao Toshihisa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 顆粒球及びマスト細胞　好塩基球はトロゴサイトーシスを介して樹状細胞(DC)由来のペプチドMHCクラスII複合体を獲得し抗原を提示する(Granulocyte & Mast cells　Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells(DCs)). 日本免疫学会総会・学術集会記録 2017.12.01

  106. Kojima Toshiyuki, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 粘膜皮膚免疫(2)　新規CD200相同体のiSEC1とiSEC2は抑制性受容体CD200Rの胃腸分泌型細胞特異的リガンドである(Mucosal-Skin Immunity(2)　Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R). 日本免疫学会総会・学術集会記録 2017.12.01

  107. Karasuyama Hajime. アレルギー　最先端　アレルギー性炎症と免疫調節における好塩基球の新たな役割(Allergy: state-of-the-art　Emerging roles of basophils in allergic inflammation and immune regulation). 日本免疫学会総会・学術集会記録 2017.12.01

  108. Takahiro Adachi, Yoshikawa Soichiro, Karasuyama Hajime. B細胞の発生と機能　Ca2+バイオセンサーYC3.60導入マウスのリンパ球におけるCa2+シグナルの生体内イメージング(B cell development and function　Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice). 日本免疫学会総会・学術集会記録 2017.12.01

  109. Miyake Kensuke, Shiozawa Nozomu, Nagao Toshihisa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 顆粒球及びマスト細胞　好塩基球はトロゴサイトーシスを介して樹状細胞(DC)由来のペプチドMHCクラスII複合体を獲得し抗原を提示する(Granulocyte & Mast cells　Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells(DCs)). 日本免疫学会総会・学術集会記録 2017.12.01

  110. Kojima Toshiyuki, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 粘膜皮膚免疫(2)　新規CD200相同体のiSEC1とiSEC2は抑制性受容体CD200Rの胃腸分泌型細胞特異的リガンドである(Mucosal-Skin Immunity(2)　Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R). 日本免疫学会総会・学術集会記録 2017.12.01

  111. Karasuyama Hajime. アレルギー　最先端　アレルギー性炎症と免疫調節における好塩基球の新たな役割(Allergy: state-of-the-art　Emerging roles of basophils in allergic inflammation and immune regulation). 日本免疫学会総会・学術集会記録 2017.12.01

  112. Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Sato Shingo, Karasuyama Hajime. アレルギー(3)　アレルギー性皮膚炎、食物アレルギー、アレルギー性結膜炎　IgE媒介性遅発性アレルギー性炎症において好塩基性tryptase mMCP-11は極めて重要な役割を果たす(Allergy: Allergic dermatitis, food allergy and allergic conjunctivitis　Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation). 日本免疫学会総会・学術集会記録 2017.12.01

  113. SHIBATA Sho, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime. COPDマウスモデルにおいて肺の単球由来マクロファージはMMP-12産生を通して肺気腫の発生に関与する(Allergy: Lower airway allergic inflammation　Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP-12 production in a mouse model of COPD). 日本免疫学会総会・学術集会記録 2017.12.01

  114. Takahiro Adachi, Yoshikawa Soichiro, Karasuyama Hajime. B細胞の発生と機能　Ca2+バイオセンサーYC3.60導入マウスのリンパ球におけるCa2+シグナルの生体内イメージング(B cell development and function　Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice). 日本免疫学会総会・学術集会記録 2017.12.01

  115. Karasuyama Hajime. アレルギー　最先端　アレルギー性炎症と免疫調節における好塩基球の新たな役割(Allergy: state-of-the-art　Emerging roles of basophils in allergic inflammation and immune regulation). 日本免疫学会総会・学術集会記録 2017.12.01

  116. Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Sato Shingo, Karasuyama Hajime. アレルギー(3)　アレルギー性皮膚炎、食物アレルギー、アレルギー性結膜炎　IgE媒介性遅発性アレルギー性炎症において好塩基性tryptase mMCP-11は極めて重要な役割を果たす(Allergy: Allergic dermatitis, food allergy and allergic conjunctivitis　Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation). 日本免疫学会総会・学術集会記録 2017.12.01

  117. Yoshikawa Soichiro, Oh-hora Masatsugu, Miyake Kensuke, Kawano Yohei, Yamanashi Yoshinori, Karasuyama Hajime. アレルギー(2)　上気道アレルギー性炎症とアレルギー反応　好塩基球におけるSTIM2を介した長期間にわたるCa2+の流入はサイトカイン誘導IL-4産生にとって不可欠である(Allergy: Upper airway allergic inflammation and allergic responses　Prolonged Ca2+ influx via STIM2 is essential for cytokine-induced IL-4 production in basophil). 日本免疫学会総会・学術集会記録 2017.12.01

  118. SHIBATA Sho, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime. COPDマウスモデルにおいて肺の単球由来マクロファージはMMP-12産生を通して肺気腫の発生に関与する(Allergy: Lower airway allergic inflammation　Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP-12 production in a mouse model of COPD). 日本免疫学会総会・学術集会記録 2017.12.01

  119. Kojima Toshiyuki, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 粘膜皮膚免疫(2)　新規CD200相同体のiSEC1とiSEC2は抑制性受容体CD200Rの胃腸分泌型細胞特異的リガンドである(Mucosal-Skin Immunity(2)　Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R). 日本免疫学会総会・学術集会記録 2017.12.01

  120. OHTA Takuya, YOSHIKAWA Soichiro, YAMAJI Kayoko, ISHIWATA Kenji, TABAKAWA Yuya, KAWANO Yohei, YAMANISHI Yoshinori, WATANABE Naohiro, KANUKA Hirotaka, KARASUYAMA Hajime. 顆粒球及びマスト細胞　皮膚常在CD4陽性メモリーT細胞はIL-3を介して好塩基球を動員しダニ抵抗性の獲得において重要な役割を果たす(Granulocyte & Mast cells　Skin-resident memory CD4+ T cells play an essential role in acquired tick resistance through IL-3-mediated basophil recruitment). 日本免疫学会総会・学術集会記録 2017.12.01

  121. NAGAO Toshihisa, TERANISHI Mio, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime. 顆粒球及びマスト細胞　担体タンパク質の糖修飾によりアレルゲンはIgEおよび好塩基球媒介性のアレルギー性炎症誘発能を獲得する(Granulocyte & Mast cells　Sugar modification of carrier protein confers ability on allergen to induce IgE- and basophil-mediated allergic inflammation). 日本免疫学会総会・学術集会記録 2017.12.01

  122. Tsutsui Hidemitsu, Yamanishi Yoshinori, Ohtsuka Hiromi, Sato Shingo, Yoshikawa Soichiro, Karasuyama Hajime. 顆粒球及びマスト細胞　好塩基球特異的プロテアーゼmMCP-8は微小血管透過性亢進および白血球浸潤により皮膚における炎症反応を誘発する(Granulocyte & Mast cells　The basophil-specific protease mMCP-8 provokes an inflammatory response in the skin with microvascular hyperpermeability and leukocyte infiltration). 日本免疫学会総会・学術集会記録 2017.12.01

  123. Miyake Kensuke, Shiozawa Nozomu, Nagao Toshihisa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 顆粒球及びマスト細胞　好塩基球はトロゴサイトーシスを介して樹状細胞(DC)由来のペプチドMHCクラスII複合体を獲得し抗原を提示する(Granulocyte & Mast cells　Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells(DCs)). 日本免疫学会総会・学術集会記録 2017.12.01

  124. Bando Tomoyuki, Fujita Setsuko, Nagano Naoko, Yoshikawa Soichiro, Yamanishi Yoshinori, Minami Masashi, Karasuyama Hajime. 顆粒球及びマスト細胞　マスト細胞と好塩基球によるプロスタグランジン産生におけるCOX-1とCOX-2の利用の差(Granulocyte & Mast cells　Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils). 日本免疫学会総会・学術集会記録 2017.12.01

  125. TABAKAWA Yuya, OHTA Takuya, YOSHIKAWA Soichiro, YAMAJI Kayoko, ISHIWATA Kenji, KAWANO Yohei, YAMANISHI Yoshinori, WATANABE Naohiro, OHTSU Hiroshi, KANUKA Hirotaka, KARASUYAMA Hajime. 顆粒球及びマスト細胞　ダニ寄生に対する獲得防御免疫においてhistamineは重要な役割を果たす(Granulocyte & Mast cells　Histamine plays a critical role in acquired protective immunity against tick infestation). 日本免疫学会総会・学術集会記録 2017.12.01

  126. Watabe Taro, Nagaishi Takashi, Hosoya Akinori, Jose Nisha, Tsugawa Naoya, Kojima Yudai, Yoshikawa Soichiro, Karasuyama Hajime, Adachi Takahiro, Watanabe Mamoru. 組織特異的免疫疾患(III)　実験的結腸炎モデルにおける生体内イメージングによる回盲免疫反応の分析(Tissue-specific immune diseases(III)　Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging). 日本免疫学会総会・学術集会記録 2017.12.01

  127. Tsugawa Naoya, Nagaishi Takashi, Watabe Taro, Jose Nisha, Hosoya Akinori, Kojima Yudai, Yoshikawa Soichiro, Karasuyama Hajime, Adachi Takahiro, Watanabe Mamoru. 粘膜皮膚免疫(2)　粘膜の細菌叢とホメオスタシスに対する免疫グロブリンAによる制御の検証(Mucosal-Skin Immunity(2)　Verification of immunoglobulin A regulation of mucosal microflora and homeostasis). 日本免疫学会総会・学術集会記録 2017.12.01

  128. Takahiro Adachi, Yoshikawa Soichiro, Karasuyama Hajime. B細胞の発生と機能　Ca2+バイオセンサーYC3.60導入マウスのリンパ球におけるCa2+シグナルの生体内イメージング(B cell development and function　Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice). 日本免疫学会総会・学術集会記録 2017.12.01

  129. Karasuyama Hajime. アレルギー　最先端　アレルギー性炎症と免疫調節における好塩基球の新たな役割(Allergy: state-of-the-art　Emerging roles of basophils in allergic inflammation and immune regulation). 日本免疫学会総会・学術集会記録 2017.12.01

  130. Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Sato Shingo, Karasuyama Hajime. アレルギー(3)　アレルギー性皮膚炎、食物アレルギー、アレルギー性結膜炎　IgE媒介性遅発性アレルギー性炎症において好塩基性tryptase mMCP-11は極めて重要な役割を果たす(Allergy: Allergic dermatitis, food allergy and allergic conjunctivitis　Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation). 日本免疫学会総会・学術集会記録 2017.12.01

  131. SHIBATA Sho, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime. COPDマウスモデルにおいて肺の単球由来マクロファージはMMP-12産生を通して肺気腫の発生に関与する(Allergy: Lower airway allergic inflammation　Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP-12 production in a mouse model of COPD). 日本免疫学会総会・学術集会記録 2017.12.01

  132. Kojima Toshiyuki, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 粘膜皮膚免疫(2)　新規CD200相同体のiSEC1とiSEC2は抑制性受容体CD200Rの胃腸分泌型細胞特異的リガンドである(Mucosal-Skin Immunity(2)　Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R). 日本免疫学会総会・学術集会記録 2017.12.01

  133. Miyake Kensuke, Shiozawa Nozomu, Nagao Toshihisa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 顆粒球及びマスト細胞　好塩基球はトロゴサイトーシスを介して樹状細胞(DC)由来のペプチドMHCクラスII複合体を獲得し抗原を提示する(Granulocyte & Mast cells　Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells(DCs)). 日本免疫学会総会・学術集会記録 2017.12.01

  134. Yoshinori Yamanishi, Misako Iki, Kensei Tanaka, Hayato Deki, Mio Fujimaki, Shingo Sato, Soichiro Yoshikawa, Hajime Karasuyama. Basophil tryptase mMCP-11 plays a crucial role in the IgE-mediated chronic allergic inflammation.. The 66th Annual Meeting of Japanese Society of Allergology 2017.06.15 Tokyo, Japan

  135. Hajime Karasuyama. Basophils in immune-mediated disease. Third International Symposium on IgG4-RD and Fibrosis 2017.02.16 Hawaii, USA

  136. Karasuyama, H.. Emerging roles of basophils in allergy and immunity.. 41th JSID Annual Meeting 2016.12.09 Sendai

  137. Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Moe Kawawa, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Basophils gain the capacity of antigen presentation by acquiring MHC class II molecules from dendritic cells through trogocytosis. 第45回日本免疫学会学術集会 2016.12.06

  138. Iki, M., Tanaka, K., Deki, H., Nagao, T, Horibe, M., Sato, S., Yoshikawa, S., Yamanishi Y., Karasuyama, H.. Basophil-selective mMCP-11 plays crucial roles in the development of IgE-mediated chronic allergic inflammation in the skin.. The 45th Annual Meeting of the Japanese Society for Immunology 2016.12.06 Okinawa

  139. Yoshikawa, S., Oh-hora, M., Yamanishi, Y., Karasuyama, H.. STIM2 plays essential role in cytokine-induced IL-4 production in basophil.. The 45th Annual Meeting of The Japanese Society for Immunology 2016.12.05 Okinawa, Japan

  140. Karasuyama, H.. Emerging roles of basophils in acquired protective immunity to tick infestation.. XXV International Congress of Entomology 2016.09.29 Orland

  141. Nagao, T., Takahashi, S., Kawawa, M., Miyake, K., Yoshikawa, S., Yamanishi, Y., Karasuyama, H.. Sugar modification of carrier protein in allergen determines the magnitude of IgE- and basophil-mediated allergic inflammation.. International Congress of Immunology 2016 2016.08.23 Melbourne, Autralia

  142. Tsutsui, H., Yamanishi, Y., Yoshikawa, S., Sato, S., Karasuyama, H.. mMCP-8, a basophil specific protease, triggers an inflammatory response by stimulating fibroblasts to produce chemokines. The 16th International Congress of Immunology.. International Congress of Immunology 2016 2016.08.23 Melbourne, Autralia

  143. Yoshikawa, S., Oh-hora, M., Adachi, T., Yamanishi, Y., karasuyama, H. . STIM1/2 plays essential role in basophil activation and development of IgE-mediated chronic allergic inflammation. . International Congress of Immunology 2016 2016.08.21 Melbourne, Autralia

  144. Karasuyama, H.. Emerging roles of basophils and IgE in allergy and immunity.. FASEB Science Research Conference 2016.07.26 Florida

  145. Nagao, T., Takahashi, S., Kawawa, M., Miyake, K., Yoshikawa, S., Sato, S., Yamanishi, Y., Karasuyama, H.. Molecular properties of carrier protein in allergen are critical for the development of IgE- and basophil-mediated allergic inflammation in the skin.. Environment controlling normal and diseased hematopoetic and immune systems 2016.03.02 Yokohama, Japan

  146. Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Basophils acquire MHC class II molecules from DCs and exert antigen presenting capacity. 第44回日本免疫学会学術集会 2015.11.18

  147. Nagao T, Takahashi S, Kawawa M, Miyake K, Yoshikawa S, Sato S, Yamanishi Y, Karasuyama H.. Molecular properties of carrier protein in allergen are critical for the development of IgE-mediated chronic allergic inflammation in the skin: what makes a foreign material to be an allergen?. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.18 Sapporo, Japan

  148. Miyake K, Shiozawa N, Nagao T, Yahagi Y, Yoshikawa S, Yamanishi Y, Karasuyama H. Basophils acquire MHC class II molecules from DCs and exert antigen presenting capacity.. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.18 Sapporo, Japan

  149. Tsutsui H, Yamanishi Y, Tatebayashi S, Yoshikawa S, Sato S, Karasuyama H. Basophil-specific protease mMCP-8 triggers skin inflammation through activation of dermal fibroblasts.. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.18 Sapporo, Japan

  150. Toyama S, Matsuda A, Saito H, Nakae S, Karasuyama H, Matsumoto K. A novel protease, PRSS33 (serine protease 33) is specifically and constitutively expressed in Eosinophils.. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.18 Sapporo, Japan

  151. Hajime Karasuyama. Emerging roles of basophils in acquired protective immunity to parasitic infections.. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.18 Sapporo, Japan

  152. Hajime Karasuyama. Basophils play critical roles in allergy and protective immunity in the skin.. 14th International Workshop on Langerhans Cells 2015.11.07 Kyoto, Japan

  153. Hajime Karasuyama. Basophils have immerged as a key player in immunity.. RIKEN-IMS Seminar 2015.10.29 Yokohama, Japan

  154. Hajime Karasuyama. Basophil: A Key Player in Immunity and Inflammation. XXIV World Allergy Congress (WAC 2015) 2015.10.17 Seoul, Korea

  155. Kensuke Miyake, Toshihisa Nagao, Yuto Yahagi, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. GM-CSF can promote MHC class II expression and ability of antigen presentation in basophils. 第64回日本アレルギー学会学術大会 2015.05.26

  156. Hajime Karasuyama. Non-redundant roles of basophils in Th2-type protective immunity and allergy.. Cell Symposium “The multifaceted roles of type 2 immunity” 2014.12.11 Bruges, Belgium

  157. Soichiro Yoshikawa, Masatsugu Ho-hora, Minoru Wakamori, Kensuke Miyake, Lihua Li, Kayo Horiguchi, Takuya Ohta, Takahiro Adachi, Yoshinori Yamanishi, and Hajime Karasuyama.. Molecular mechanism underlying Ca2+ influx due to IgE/antigen stimulation in basophils.. The 43th JSI Symposium 2014.12.10 Kyoto

  158. Hajime Karasuyama. Non-redundant roles for basophils in allergy and protective immunity.. British Society for Immunology Congress 2014 2014.12.02 Brighton, UK

  159. Hajime Karasuyama. Emerging roles of basophils in allergy and protective immunity.. Medical Research Institute 40th Anniversary Symposium. 2014.11.28 Tokyo

  160. Hajime Karasuyama. Basophils have emerged as a key player in immunity.. The 24th Hot Spring Harbor International Symposium 2014.11.08 Fukuoka

  161. Hajime Karasuyama. Basophils have emerged as a key player in immunity.. Cold Spring Harbor Asia Conference “Frontiers of Immunology in Health and Diseases” 2014.09.04 Suzhou, China

  162. Hajime Karasuyama. Non-redundant roles of basophils in immunity-a neglected minority gains new respect.. The 24th Congress of Interasma Japan/North Asia 2014.07.19 Nagoya

  163. Hajime Karasuyama. Role of basophils in allergic inflammation and protective immunity.. 12th ERS Lung Science Conference 2014.03.22 Estoril, Portugal

  164. Hajime Karasuyama. Emerging roles for basophils in health and disease.. The 3rd Bizan Immunology Symposium 2014.02.14 Tokushima

  165. Hajime Karasuyama. Emerging roles for basophils in immunity: a neglected minority gains new respect. . NIF Winter School on Advanced Immunology 2014.01.19 Awaji

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Awards & Honors 【 display / non-display 】

  • Tokyo Medical and Dental University President Award (Hajime Karasuyama)，Tokyo Medical and Dental University，2014.10

  • The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Prizes for Science and Technology (Research Category) (Hajime Karasuyama)，Ministry of Education, Culture, Sports, Science and Technology，2014.04

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Others 【 display / non-display 】

  • Pre-basophils: A basophil origin story，2023.06

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Campus class subject 【 display / non-display 】

  • Immunology

  • Immunology

  • Biochemistry

  • Immunology

  • Immunology

  • Biochemistry

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