Personnel Information

写真a

KARASUYAMA Hajime


Job title

Distinguished Professor

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519

Laboratory Phone number

+81-3-5803-5162

Laboratory Fax number

+81-3-3814-7172

Mail Address

karasuyama.mbch@tmd.ac.jp

Homepage URL

http://immune-regulation.org/index.php?id=27

Research Areas, Keywords

allergy, basophil, B cell development, immunodeficiency, autoimmune, infection

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 1978, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Doctor's Course, 1984, Completed

Degree 【 display / non-display

  • MD., PhD., The University of Tokyo

Campus Career 【 display / non-display

  • 2000.01
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Immune Regulation, Professor
  • 2008.04
    -
    2014.03
    Tokyo Medical and Dental University, Executive Vice President, Deputy Director
  • 2014.04
    -
    2020.03
    Tokyo Medical and Dental University, Board Member, Executive Director
  • 2020.04
    -
    Now
    Tokyo Medical and Dental University, , , Distinguished Professor

External Career 【 display / non-display

  • 1978 Tokyo Medical and Dental University School of Medicine MD.1978,
  • 1980-1984 Postgraduate, Department of Immunology, Faculty of Medicine, University of Tokyo,
  • PhD., 1984.,
  • 1984-1987 Scientific member, Basel Institute for Immunology, Basel, Switzerland,
  • 1987-1990 Research Associate, Department of Immunology, Faculty of Medicine, University of Tokyo,

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Academic Society Affiliations 【 display / non-display

  • Japanese Society for Immunology

  • Japanese Society of Allergology

  • The Molecular Biology Society of Japan

  • Japanese Cancer Association

  • Japanese Society of Hematology

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Academic Activity 【 display / non-display

  • Japanese Society for Immunology Board member
  • Japanese Society of Allergology Board of representatives

Research Areas 【 display / non-display

  • Immunology

  • Cell biology

  • Collagenous pathology/Allergology

 

Research Theme 【 display / non-display

  • Genetic origins and pathogenesis of primary immunodeficiencies

  • Roles of basophils in protective immunity, immune regulation and allergy

  • Cellular and molecular basis of chronic allergic inflammation

  • Molecular mechanisms for regulation of lymphocyte development

Published Papers & Misc 【 display / non-display

  • Lin YH, Tahara-Hanaoka S, Nagai K, Yoshikawa S, Kubo M, Shibayama S, Karasuyama H, Shibuya A. Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice. International Immunology. 2019.12; 32 (3): 213-219. ( PubMed, DOI )

  • Kashiwakura J, Ando T, Karasuyama H, Kubo M, Matsumoto K, Matsuda T, Kawakami T. The basophil-IL-4-mast cell axis is required for food allergy. Allergy. 2019.10; 74 (10): 1992-1996. ( PubMed, DOI )

  • Hashimoto T, Satoh T, Karasuyama H, Yokozeki H. Amphiregulin from Basophils Amplifies Basophil-Mediated Chronic Skin Inflammation. Journal of Investigative Dermatology. 2019.08; 139 (8): 1834-1837.e2. ( PubMed, DOI )

  • Balam S, Schiechl-Brachner G, Buchtler S, Halbritter D, Schmidbauer K, Talke Y, Neumayer S, Salewski NJ, Winter F, Karasuyama H, Yamanishi Y, Renner K, Geissler EK, Mack M. IL-3 Triggers Chronic Rejection of Cardiac Allografts by Activation of Infiltrating Basophils. Journal of Immunology. 2019.06; 202 (12): 3514-3523. ( PubMed, DOI )

  • Piliponsky AM, Shubin NJ, Lahiri AK, Truong P, Clauson M, Niino K, Tsuha AL, Nedospasov SA, Karasuyama H, Reber LL, Tsai M, Mukai K, Galli SJ. Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice. Nature Immunology. 2019.02; 20 (2): 129-140. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Takahiro Adachi, Taro Watabe, Takashi Nagaishi, Mamoru Watanabe, Hajime Karasuyama, Soichiro Yoshikawa. IgA-deficiency causes spontaneous enteritis.. The 48th Annual Meeting of the Japanese Society for Immunology 2019.12.13 Hamamatsu(Japan)

  • Kensuke Miyake, Ayako Fukui, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Basophils promote monocyte differentiation to M2-like macrophages that display enhanced capacity of allergen clearance. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.11 Fukuoka

  • Toshihisa Nagao, Yoshinori Yamanishi, Kensuke Miyake, Mio Teranishi, Soichiro Yoshikawa, Yohei Kawano, Hajime Karasuyama. Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.11 Fukuoka

  • Soichiro Yoshikawa, Yuya Tabakawa, Takuya Ohta, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Yoshinori Yamanishi, Hiroshi Ohtsu, Takahiro Adachi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama. Histamine Released From Skin-Infiltrating Basophils but not mast cells is crucial for acquired tick resistance in mice. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.11 Fukuoka

  • Yohei Kawano, Georg Petkau, Christina Stehle, Pawel Durek, Gitta Anne Heinz, Kousuke Tanimoto, Hajime Karasuyama, Mir-Farzin Mashreghi, Chiara Romagnani, Fritz Melchers. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.10 Fukuoka

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Awards & Honors 【 display / non-display

  • Tokyo Medical and Dental University President Award (Hajime Karasuyama),Tokyo Medical and Dental University,2014.10

  • The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Prizes for Science and Technology (Research Category) (Hajime Karasuyama),Ministry of Education, Culture, Sports, Science and Technology,2014.04

 

Campus class subject 【 display / non-display

  • Immunology

  • Immunology

  • Biochemistry