Personnel Information

写真a

KARASUYAMA Hajime


Job title

Deputy Director

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519

Laboratory Phone number

+81-3-5803-4609

Laboratory Fax number

+81-3-3814-7172

Mail Address

karasuyama.mbch@tmd.ac.jp

Homepage URL

http://immune-regulation.org/index.php?id=27

Research Areas, Keywords

allergy, basophil, B cell development, immunodeficiency, autoimmune, infection

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 1978, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Doctor's Course, 1984, Completed

Degree 【 display / non-display

  • MD., PhD., The University of Tokyo

Campus Career 【 display / non-display

  • 2000.10
    -
    2019.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Immune Regulation, Professor
  • 2008.04
    -
    2014.03
    Tokyo Medical and Dental University, Executive Vice President, Deputy Director
  • 2014.04
    -
    2020.03
    Tokyo Medical and Dental University, Board Member, Executive Director
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University, , , Distinguished Professor
  • 2020.10
    -
    2021.01
    Tokyo Medical and Dental University, , Deputy Director

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External Career 【 display / non-display

  • 1978 Tokyo Medical and Dental University School of Medicine MD.1978,
  • 1980-1984 Postgraduate, Department of Immunology, Faculty of Medicine, University of Tokyo,
  • PhD., 1984.,
  • 1984-1987 Scientific member, Basel Institute for Immunology, Basel, Switzerland,
  • 1987-1990 Research Associate, Department of Immunology, Faculty of Medicine, University of Tokyo,

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Academic Society Affiliations 【 display / non-display

  • Japanese Society for Immunology

  • Japanese Society of Allergology

  • The Molecular Biology Society of Japan

  • Japanese Cancer Association

  • Japanese Society of Hematology

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Academic Activity 【 display / non-display

  • Japanese Society for Immunology Board member
  • Japanese Society of Allergology Board of representatives

Research Areas 【 display / non-display

  • Immunology

  • Cell biology

  • Collagenous pathology/Allergology

Qualification Acquired 【 display / non-display

  • Doctor

 

Research Theme 【 display / non-display

  • Genetic origins and pathogenesis of primary immunodeficiencies

  • Roles of basophils in protective immunity, immune regulation and allergy

  • Cellular and molecular basis of chronic allergic inflammation

  • Molecular mechanisms for regulation of lymphocyte development

Published Papers & Misc 【 display / non-display

  • Karasuyama H, Shibata S, Yoshikawa S, Miyake K. Basophils, a neglected minority in the immune system, have come into the limelight at last. International immunology. 2021.05; ( PubMed, DOI )

  • Nagaishi T, Watabe T, Kotake K, Kumazawa T, Aida T, Tanaka K, Ono R, Ishino F, Usami T, Miura T, Hirakata S, Kawasaki H, Tsugawa N, Yamada D, Hirayama K, Yoshikawa S, Karasuyama H, Okamoto R, Watanabe M, Blumberg RS, Adachi T. Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum. Gut. 2021.05; ( PubMed, DOI )

  • Miyake Kensuke, Karasuyama Hajime. The Role of Trogocytosis in the Modulation of Immune Cell Functions CELLS. 2021.05; 10 (5): ( PubMed, DOI )

  • Wanet Anais, Bassal Mahmoud A., Patel Sweta B., Marchi Francisco, Mariani Samanta A., Ahmed Nouraiz, Zhang Haoran, Borchiellini Marta, Chen Sisi, Zhang Junyan, Di Ruscio Annalisa, Miyake Kensuke, Tsai Mindy, Paranjape Anuya, Park Shin-Young, Karasuyama Hajime, Schroeder Timm, Dzierzak Elaine, Galli Stephen J., Tenen Daniel G., Welner Robert S.. E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates SCIENCE IMMUNOLOGY. 2021.02; 6 (56): ( PubMed, DOI )

  • Miyake Kensuke, Shibata Sho, Yoshikawa Soichiro, Karasuyama Hajime. Basophils and their effector molecules in allergic disorders ALLERGY. 2020.11; ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Kensuke Miyake, Hajime Karasuyama. Basophils present antigens to T cells via trogocytosis-mediated acquisition of MHC class II. 第43回日本分子生物学会年会(MBSJ2020) 2020.12.04

  • Junya Ito, Kensuke Miyake, Shigeyuki Shichino, Yoshinori Yamanishi, Hajime Karasuyama. Identification of two distinct subpopulations among basophils in the bone marrow. JSA/WAO Joint Congress 2020 2020.09

  • Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation. JSA/WAO Joint Congress 2020 2020.09

  • Takahiro Adachi, Taro Watabe, Takashi Nagaishi, Mamoru Watanabe, Hajime Karasuyama, Soichiro Yoshikawa. IgA-deficiency causes spontaneous enteritis.. The 48th Annual Meeting of the Japanese Society for Immunology 2019.12.13 Hamamatsu(Japan)

  • Mogi Kotone, Takahashi Kazufusa, Miyake Kensuke, Yoshikawa Soichiro, Karasuyama Hajime, Yamanishi Yoshinori. Allergy-1: skin inflammation Basophil-derived IL-4 promotes disease progression in a hapten-elicited murine model of atopic dermatitis(和訳中). 日本免疫学会総会・学術集会記録 2019.11.01

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Awards & Honors 【 display / non-display

  • Tokyo Medical and Dental University President Award (Hajime Karasuyama),Tokyo Medical and Dental University,2014.10

  • The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Prizes for Science and Technology (Research Category) (Hajime Karasuyama),Ministry of Education, Culture, Sports, Science and Technology,2014.04

 

Campus class subject 【 display / non-display

  • Immunology

  • Immunology

  • Biochemistry