Personnel Information

写真a

SAEGUSA Hironao


Job title

Assistant Professor

Laboratory Phone number

+81-3-5803-5170

Mail Address

The inquiry by e-mail is 《here》

Research Areas, Keywords

calcium channel, microglia, neurodegenerative diseae
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Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Science, 1988.03, Graduated

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Graduate School 【 display / non-display 】

  • Nagoya University, Graduate School, Division of Natural Science, Doctor's Course, 1993.03, Completed

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Degree 【 display / non-display 】

  • Ph.D, Nagoya University

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Campus Career 【 display / non-display 】

  • 1900.01
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Pharmacology and Neurobiology， Assistant Professor
  • 2018.04
    -
    2022.05
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Pharmacology and Neurobiology， Assistant Professor
  • 2022.06
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Physiology and Cell Biology， Assistant Professor
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Research Areas 【 display / non-display 】

  • Neuroscience-general

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Published Papers & Misc 【 display / non-display 】

  1. Saegusa Hironao, Li Xu, Wang Xinshuang, Kayakiri Midori, Tanabe Tsutomu. Knockdown of microglial Cav2.2 N-type voltage-dependent Ca(2+)channel ameliorates behavioral deficits in a mouse model of Parkinson's disease FEBS LETTERS. 2020.06; ( PubMed, DOI )

  2. Huntula, S., Wang, X., Saegusa, H. and Tanabe, T.. Involvement of N-type Ca2+ channel in microglial activation and its implications to aging-induced exaggerated cytokine response. Cell Calcium. 2019.07; 82 102059. ( DOI )

  3. Wang, X., Saegusa, H., Huntula, S. and Tanabe, T. . Blockade of microglial Cav1.2 Ca2+ channel exacerbates the symptoms in a Parkinson’s disease model. Scientific Reports . 2019.06; 9 (9138): ( DOI )

  4. Daisuke Kondo, Hironao Saegusa, Tsutomu Tanabe. Involvement of phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin/peroxisome proliferator-activated receptor γ pathway for induction and maintenance of neuropathic pain. Biochem. Biophys. Res. Commun.. 2018.05; 499 (2): 253-259. ( PubMed, DOI )

  5. Hironao Saegusa, Tsutomu Tanabe. N-type voltage-dependent Ca2+ channel in non-excitable microglial cells in mice is involved in the pathophysiology of neuropathic pain. Biochem. Biophys. Res. Commun.. 2014.07; 450 (1): 142-147. ( PubMed, DOI )

  6. Li L, Saegusa H, Tanabe T. Deficit of heat shock transcription factor 1-heat shock 70 kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 6. Genes Cells. 2009.11; 14 (11): 1253-1269. ( PubMed, DOI )

  7. Kondo D, Saegusa H, Yabe R, Takasaki I, Kurihara T, Zong S, Tanabe T. Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice. J Pharmacol Sci. 2009.05; 110 (1): 55-63. ( PubMed )

  8. Okamoto N, Yamanaka N, Satake H, Saegusa H, Kataoka H, Mizoguchi A. An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori. FEBS J. 2009.03; 276 (5): 1221-1232. ( PubMed, DOI )

  9. Sakurai E, Kurihara T, Kouchi K, Saegusa H, Zong S, Tanabe T. Upregulation of casein kinase 1epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain. Mol Pain. 2009; 5 74. ( PubMed, DOI )

  10. Saegusa H, Wakamori M, Matsuda Y, Wang J, Mori Y, Zong S, Tanabe T. Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells. Mol Cell Neurosci. 2007.02; 34 (2): 261-270. ( PubMed, DOI )

  11. Kondo D, Yabe R, Kurihara T, Saegusa H, Zong S, Tanabe T. Progesterone receptor antagonist is effective in relieving neuropathic pain. Eur J Pharmacol. 2006.07; 541 (1-2): 44-48. ( PubMed, DOI )

  12. Osanai M, Saegusa H, Kazuno AA, Nagayama S, Hu Q, Zong S, Murakoshi T, Tanabe T. Altered cerebellar function in mice lacking CaV2.3 Ca2+ channel. Biochem Biophys Res Commun. 2006.06; 344 (3): 920-925. ( PubMed, DOI )

  13. Takasaki I, Kurihara T, Saegusa H, Zong S, Tanabe T. Effects of glucocorticoid receptor antagonists on allodynia and hyperalgesia in mouse model of neuropathic pain. Eur J Pharmacol. 2005.11; 524 (1-3): 80-83. ( PubMed, DOI )

  14. Hu Q, Saegusa H, Hayashi Y, Tanabe T. The carboxy-terminal tail region of human Cav2.1 (P/Q-type) channel is not an essential determinant for its subcellular localization in cultured neurones. Genes Cells. 2005.02; 10 (2): 87-96. ( PubMed, DOI )

  15. Yokoyama K, Kurihara T, Saegusa H, Zong S, Makita K, Tanabe T. Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance. Eur J Neurosci. 2004.12; 20 (12): 3516-3519. ( PubMed, DOI )

  16. Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T. Increased sensitivity to halothane but decreased sensitivity to propofol in mice lacking the N-type Ca2+ channel. Neurosci Lett. 2003.10; 350 (1): 41-45. ( PubMed )

  17. Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T. Anesthetic sensitivities to propofol and halothane in mice lacking the R-type (Cav2.3) Ca2+ channel. Anesth Analg. 2003.07; 97 (1): 96-103, table of contents. ( PubMed )

  18. Han W, Saegusa H, Zong S, Tanabe T. Altered cocaine effects in mice lacking Ca(v)2.3 (alpha(1E)) calcium channel. Biochem Biophys Res Commun. 2002.11; 299 (2): 299-304. ( PubMed )

  19. Saegusa H, Matsuda Y, Tanabe T. Effects of ablation of N- and R-type Ca(2+) channels on pain transmission. Neurosci Res. 2002.05; 43 (1): 1-7. ( PubMed )

  20. Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T. Ca(v)2.3 (alpha1E) Ca2+ channel participates in the control of sperm function. FEBS Lett. 2002.04; 516 (1-3): 229-233. ( PubMed )

  21. Tsunemi T, Saegusa H, Ishikawa K, Nagayama S, Murakoshi T, Mizusawa H, Tanabe T. Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. J Biol Chem. 2002.03; 277 (9): 7214-7221. ( PubMed, DOI )

  22. Toriyama H, Wang L, Saegusa H, Zong S, Osanai M, Murakoshi T, Noda T, Ohno K, Tanabe T. Role of Ca(v) 2.3 (alpha1E ) Ca2+ channel in ischemic neuronal injury. Neuroreport. 2002.02; 13 (2): 261-265. ( PubMed )

  23. Matsuda Y, Saegusa H, Zong S, Noda T, Tanabe T. Mice lacking Ca(v)2.3 (alpha1E) calcium channel exhibit hyperglycemia. Biochem Biophys Res Commun. 2001.12; 289 (4): 791-795. ( PubMed, DOI )

  24. Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T. Analysis of Ca(2+) currents in spermatocytes from mice lacking Ca(v)2.3 (alpha(1E)) Ca(2+) channel. Biochem Biophys Res Commun. 2001.11; 288 (4): 1032-1036. ( PubMed, DOI )

  25. Saegusa H, Kurihara T, Zong S, Kazuno A, Matsuda Y, Nonaka T, Han W, Toriyama H, Tanabe T. Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel. EMBO J. 2001.05; 20 (10): 2349-2356. ( PubMed, DOI )

  26. Kubota M, Murakoshi T, Saegusa H, Kazuno A, Zong S, Hu Q, Noda T, Tanabe T. Intact LTP and fear memory but impaired spatial memory in mice lacking Ca(v)2.3 (alpha(IE)) channel. Biochem Biophys Res Commun. 2001.03; 282 (1): 242-248. ( PubMed, DOI )

  27. Masumura M, Satake S, Saegusa H, Mizoguchi A. Glucose stimulates the release of bombyxin, an insulin-related peptide of the silkworm Bombyx mori. Gen Comp Endocrinol. 2000.06; 118 (3): 393-399. ( PubMed, DOI )

  28. Saegusa H, Kurihara T, Zong S, Minowa O, Kazuno A, Han W, Matsuda Y, Yamanaka H, Osanai M, Noda T, Tanabe T. Altered pain responses in mice lacking alpha 1E subunit of the voltage-dependent Ca2+ channel. Proc Natl Acad Sci U S A. 2000.05; 97 (11): 6132-6137. ( PubMed, DOI )

  29. Toru S, Murakoshi T, Ishikawa K, Saegusa H, Fujigasaki H, Uchihara T, Nagayama S, Osanai M, Mizusawa H, Tanabe T. Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function. J Biol Chem. 2000.04; 275 (15): 10893-10898. ( PubMed )

  30. Ishikawa K, Fujigasaki H, Saegusa H, Ohwada K, Fujita T, Iwamoto H, Komatsuzaki Y, Toru S, Toriyama H, Watanabe M, Ohkoshi N, Shoji S, Kanazawa I, Tanabe T, Mizusawa H. Abundant expression and cytoplasmic aggregations of [alpha]1A voltage-dependent calcium channel protein associated with neurodegeneration in spinocerebellar ataxia type 6. Hum Mol Genet. 1999.07; 8 (7): 1185-1193. ( PubMed )

  31. Minabe-Saegusa C, Saegusa H, Tsukahara M, Noguchi S. Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach. Dev Growth Differ. 1998.06; 40 (3): 343-353. ( PubMed )

  32. Saegusa H, Takahashi N, Noguchi S, Suemori H. Targeted disruption in the mouse Hoxc-4 locus results in axial skeleton homeosis and malformation of the xiphoid process. Dev Biol. 1996.02; 174 (1): 55-64. ( PubMed, DOI )

  33. Ishibashi J, Kataoka H, Isogai A, Kawakami A, Saegusa H, Yagi Y, Mizoguchi A, Ishizaki H, Suzuki A. Assignment of disulfide bond location in prothoracicotropic hormone of the silkworm, Bombyx mori: a homodimeric peptide. Biochemistry. 1994.05; 33 (19): 5912-5919. ( PubMed )

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Books etc 【 display / non-display 】

  1. Hironao Saegusa, Tsutomu Tanabe. Pharmacology of Calcium Channels. Kluwer Academic / Plenum Publishers， 2004.09 Genetic approaches to the elucidation of calcium channel functions in vivo.

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