基本情報

写真a

畑 裕(ハタ ユタカ)

HATA Yutaka


職名

非常勤講師

研究室住所

MDタワー18階北

ホームページ

http://www.tmd.ac.jp/mbc/index.html

研究分野・キーワード

がん シグナル伝達 細胞死 細胞周期 がん遺伝子 がん抑制 筋肉 マクロファージ

出身学校 【 表示 / 非表示

  • 東京大学  医学部  1982年  卒業

取得学位 【 表示 / 非表示

  • 医学博士  

経歴(学内) 【 表示 / 非表示

  • 1900年01月
    -
    2018年03月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 生体支持組織学講座 病態代謝解析学 教授
  • 2018年04月
    -
    2022年03月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 生体支持組織学講座 病態代謝解析学 教授
  • 2022年04月
    -
    現在
    東京医科歯科大学 大学院医歯学総合研究科 医歯学専攻 先端医療開発学講座 システム発生・再生医学分野 非常勤講師

経歴(学外) 【 表示 / 非表示

  • 1999年4月 東京医科歯科大学医学部分子医化学教授
  • 2000年4月 東京医科歯科大学大学院医歯学総合研究科教授

所属学協会 【 表示 / 非表示

  • 日本生化学会

  • 日本分子生物学会

  • 日本細胞生物学会

  • 日本癌学会

  • 日本神経科学会

  • 米国微生物学会

  • 米国生化学会

▼全件表示

委員歴 【 表示 / 非表示

  • 日本生化学会 評議員
  • 日本細胞生物学会 評議員

研究分野 【 表示 / 非表示

  • 医化学

  • 病態医化学

 

研究テーマ 【 表示 / 非表示

  • Molecular dissection of the singal transduction pathway that regulates cell proliferation, cell polarity and cell death

競争的資金等の研究課題 【 表示 / 非表示

  • 腫瘍抑制分子がRASシグナル伝達において果たす非腫瘍抑制的役割

    文部科学省/日本学術振興会 : 2019年 - 2021年

  • 腫瘍抑制ヒッポ・シグナルの非規範的制御機構と非癌疾病の病態における役割の解析

    文部科学省/日本学術振興会 : 2014年 - 2016年

  • ヒッポ・パスウエイのオン・オフ機構の解明

    文部科学省/日本学術振興会 : 2010年 - 2012年

  • 腫瘍抑制分子がRASシグナル伝達において果たす非腫瘍抑制的役割

    文部科学省/日本学術振興会

論文・総説 【 表示 / 非表示

  1. Kuleape JA, Hossain S, Sinclear CK, Shimizu T, Iwasa H, Maruyama J, Arimoto-Matsuzaki K, Nishina H, Hata Y. DNA damage triggers the nuclear accumulation of RASSF6 tumor suppressor protein <i>via</i> CDK9 and BAF53 to regulate p53-target gene transcription. Molecular and cellular biology. 2021.12; MCB0031021. ( PubMed, DOI )

  2. Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y. CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells. The Journal of biological chemistry. 2021.05; 297 (1): 100803. ( PubMed, DOI )

  3. Jiang Xinliang, Maruyama Junichi, Iwasa Hiroaki, Arimoto-Matsuzaki Kyoko, Nishina Hiroshi, Hata Yutaka. Heat shock induces the nuclear accumulation of YAP1 via SRC (vol 399, 112439, 2021) EXPERIMENTAL CELL RESEARCH. 2021.04; 401 (2): 112555. ( PubMed, DOI )

  4. Jiang Xinliang, Maruyama Junichi, Iwasa Hiroaki, Arimoto-Matsuzaki Kyoko, Nishina Hiroshi, Hata Yutaka. Heat shock induces the nuclear accumulation of YAP1 via SRC EXPERIMENTAL CELL RESEARCH. 2021.02; 399 (1): 112439. ( PubMed, DOI )

  5. Lu Yuxiong, Maruyama Junichi, Sugimura Haruhiko, Hata Yutaka. Doublecortin-like kinase 1 expression is induced by alternative NF-κB signaling in human lung cancer cells(和訳中) Journal of Medical and Dental Sciences. 2021; 68 39-48. ( 医中誌 )

  6. Lu Y, Maruyama J, Kuwata K, Fukuda H, kiIwasa H, Arimoto-Matsuzaki K, Sugimura H, Hata Y. Erratum: Retraction notice to "Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability" [BBREP 16C (2018) 130-137]. Biochemistry and biophysics reports. 2020.12; 24 100799. ( PubMed, DOI )

  7. Shimizu T, Nakamura T, Inaba H, Iwasa H, Maruyama J, Arimoto-Matsuzaki K, Nakata T, Nishina H, Hata Y. The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation. The Journal of biological chemistry. 2020.06; ( PubMed, DOI )

  8. Kodaka Manami, Mao Fengju, Arimoto-Matsuzaki Kyoko, Kitamura Masami, Xu Xiaoyin, Yang Zeyu, Nakagawa Kentaro, Maruyama Junichi, Ishii Kana, Akazawa Chihiro, Oyaizu Takuya, Yamamoto Naoki, Ishigami-Yuase Mari, Tsuemoto Nozomi, Ito Shigeru, Kagechika Hiroyuki, Nishina Hiroshi, Hata Yutaka. Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells PLOS ONE. 2020.04; 15 (4): e0231265. ( PubMed, DOI )

  9. Watanabe Naoshi, Morimatsu Masatoshi, Fujita Ayano, Teranishi Mika, Sudevan Surabhi, Watanabe Masaru, Iwasa Hiroaki, Hata Yutaka, Kagi Hiroyuki, Nishiyama Masayoshi, Naruse Keiji, Higashitani Atsushi. Increased hydrostatic pressure induces nuclear translocation of DAF-16/FOXO in C. elegans BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020.03; 523 (4): 853-858. ( PubMed, DOI )

  10. 江欣 亮, 丸山 順一, 畑 裕. Heat shock-mediated regulation of transcriptional co-activator YAP1(和訳中) 日本生化学会大会プログラム・講演要旨集. 2019.09; 92回 [1P-173]. ( 医中誌 )

  11. 丸山 順一, 椙村 春彦, 畑 裕. Doublecortin-like kinase 1はDNA損傷修復機構を抑制し染色体不安定化を誘導する(Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability) 日本癌学会総会記事. 2019.09; 78回 P-3210. ( 医中誌 )

  12. ダイ ル, 松崎 京子, 畑 裕, 平岡 優一, 山本 浩平. Characterization of Hutchinson-Gilford Progeria syndrome mouse as a model to study sarcopenia(和訳中) 日本生化学会大会プログラム・講演要旨集. 2019.09; 92回 [1P-291]. ( 医中誌 )

  13. Wenzhe Qiu, Arimoto-Matsuzaki Kyoko, Kitamura Masami, Hata Yutaka. Human keratinocyte HaCaT cells form aggregates containing Ras-GAP SH3 domain-binding proteins in the cytoplasm in response to a low dose of teniposide(和訳中) Journal of Medical and Dental Sciences. 2019.06; 66 (2): 23-30. ( 医中誌 )

  14. Ito M, Hara H, Takeda N, Naito AT, Nomura S, Kondo M, Hata Y, Uchiyama M, Morita H, Komuro I. Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes. Journal of molecular and cellular cardiology. 2019.01; 128 90-95. ( PubMed, DOI )

  15. Lu Y, Maruyama J, Kuwata K, Fukuda H, Iwasa H, Arimoto-Matsuzaki K, Sugimura H, Hata Y. Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability. Biochemistry and biophysics reports. 2018.12; 16 130-137. ( PubMed, DOI )

  16. Hossain Shakhawoat, Iwasa Hiroaki, Hata Yutaka. The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via Retinoblastoma protein CANCER SCIENCE. 2018.12; 109 890.

  17. Timalsina Shikshya, Arimoto-Matsuzaki Kyoko, Kitamura Masami, Xu Xiaoyin, Qiu Wenzhe, Ishigami-Yuasa Mari, Kagechika Hiroyuki, Hata Yutaka. Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells JOURNAL OF BIOCHEMISTRY. 2018.11; 164 (5): 381-391. ( PubMed, DOI )

  18. Timalsina Shikshya, Arimoto-Matsuzaki Kyoko, Kitamura Masami, Xu Xiaoyin, Wenzhe Qiu, Ishigami-Yuasa Mari, Kagechika Hiroyuki, Hata Yutaka. Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells(和訳中) The Journal of Biochemistry. 2018.11; 164 (5): 381-391. ( 医中誌 )

  19. Hata Yutaka. Hippo Pathway in Cancer, towards the Realization of Hippo-Targeted Therapy CANCERS. 2018.10; 10 (10): ( PubMed, DOI )

  20. Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I. Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury. JACC. Basic to translational science. 2018.10; 3 (5): 639-653. ( PubMed, DOI )

  21. Hossain Shakhawoat, 岩佐 宏晃, 畑 裕. RASSF6腫瘍抑制タンパク質は網膜芽細胞腫タンパク質を介してアポトーシスと細胞周期を制御する(The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via Retinoblastoma protein) 日本癌学会総会記事. 2018.09; 77回 1539. ( 医中誌 )

  22. Iwasa Hiroaki, Sarkar Aradhan, Shimizu Takanobu, Sawada Takeru, Hossain Shakhawoat, Xu Xiaoyin, Maruyama Junichi, Arimoto-Matsuzaki Kyoko, Withanage Kanchanamala, Nakagawa Kentaro, Kurihara Hidetake, Kuroyanagi Hidehito, Hata Yutaka. 腫瘍抑制因子Ras結合ドメインファミリー6の結合パートナーであるUNC119は、MDM2およびp53によるアポトーシスおよび細胞周期停止を誘導する(UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53) Cancer Science. 2018.09; 109 (9): 2767-2780. ( 医中誌 )

  23. Li Qiaojing, Yoshimura Hideaki, Komiya Maki, Tajiri Ken, Uesugi Motonari, Hata Yutaka, Ozawa Takeaki. A robust split-luciferase-based cell fusion screening for discovering myogenesis-promoting molecules ANALYST. 2018.07; 143 (14): 3472-3480. ( PubMed, DOI )

  24. Iwasa H, Sarkar A, Shimizu T, Sawada T, Hossain S, Xu X, Maruyama J, Arimoto-Matsuzaki K, Withanage K, Nakagawa K, Kurihara H, Kuroyanagi H, Hata Y. UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53. Cancer science. 2018.06; ( PubMed, DOI )

  25. Hossain S, Iwasa H, Sarkar A, Maruyama J, Arimoto-Matsuzaki K, Hata Y. The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle <i>via</i> Retinoblastoma protein. Molecular and cellular biology. 2018.06; ( PubMed, DOI )

  26. Hara Hironori, Takeda Norifumi, Saito Tatsuo, Fujiwara Takayuki, Maemura Sonoko, Hata Yutaka, Uchiyama Masanobu, Komuro Issei. Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart after Ischemic Injury(和訳中) 日本循環器学会学術集会抄録集. 2018.03; 82回 YIA-B. ( 医中誌 )

  27. Junichi Maruyama, Kazutoshi Inami, Fumiyoshi Michishita, Xinliang Jiang, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Norio Miyamura, Jun Hirayama, Hiroshi Nishina, Daichi Nogawa, Kouhei Yamamoto, Yutaka Hata. Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth. Mol. Cancer Res.. 2018.02; 16 (2): 197-211. ( PubMed, DOI )

  28. Hiroaki Iwasa, Shakhawoat Hossain, Yutaka Hata. Tumor suppressor C-RASSF proteins. Cell. Mol. Life Sci.. 2018.01; ( PubMed, DOI )

  29. Matsuzaki Kyoko, Hata Yutaka. Chemical compounds that suppress stress granule formation enhance the cancer drug sensitivity of HeLa cells. CANCER SCIENCE. 2018.01; 109 1001.

  30. Manami Kodaka, Xiaoyin Xu, Zeyu Yang, Junichi Maruyama, Yutaka Hata. Application of Split-GFP Reassembly Assay to Study Myogenesis and Myofusion In Vitro. Methods Mol. Biol.. 2017.12; 1668 127-134. ( PubMed, DOI )

  31. Xiaoyin Xu, Hiroaki Iwasa, Shakhawoat Hossain, Aradhan Sarkar, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Yutaka Hata. BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression. Genes Cells. 2017.12; 22 (12): 993-1003. ( PubMed, DOI )

  32. 丸山 順一, 影近 弘之, 仁科 博史, 畑 裕. 新規に同定したYAP1活性化化合物は多発性骨髄腫細胞においてYAP1-p73経路依存的な細胞死を誘導する 日本癌学会総会記事. 2017.09; 76回 P-1078. ( 医中誌 )

  33. Shintaro Mandai, Susumu Furukawa, Manami Kodaka, Yutaka Hata, Takayasu Mori, Naohiro Nomura, Fumiaki Ando, Yutaro Mori, Daiei Takahashi, Yuki Yoshizaki, Yuri Kasagi, Yohei Arai, Emi Sasaki, Sayaka Yoshida, Yasuro Furuichi, Nobuharu L Fujii, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy. Sci Rep. 2017.04; 7 46369. ( PubMed, DOI )

  34. Sarkar A, Iwasa H, Hossain S, Xu X, Sawada T, Shimizu T, Maruyama J, Arimoto-Matsuzaki K, Hata Y.. Domain analysis of Ras-association domain family member 6 upon interaction with MDM2. FEBS Letters. 2017.01; 591 (2): 260-272. ( DOI )

  35. Nagashima S, Bao Y, Hata Y.. The Hippo pathway as drug targets in cancer therapy and regenerative medicine. Current Drug Targets. 2016.11;

  36. Tayo Katano, Masafumi Fukuda, Hidemasa Furue, Maya Yamazaki, Manabu Abe, Masahiko Watanabe, Kazuhiko Nishida, Ikuko Yao, Akihiro Yamada, Yutaka Hata, Nobuaki Okumura, Takanobu Nakazawa, Tadashi Yamamoto, Kenji Sakimura, Toshifumi Takao, Seiji Ito. Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury. eNeuro. 2016.10; 3 (5): ( PubMed, DOI )

  37. Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K, Yao I, Yamada A, Hata Y, Okumura N, Nakazawa T, Yamamoto T, Sakimura K, Takao T, Ito S. Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury. eNeuro. 2016.10; 3 (5): 110-116.

  38. Nagashima S, Maruyama J, Kawano S, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y. . Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif. Cancer Science. 2016.07; 107 (6): 791-802.

  39. Kodaka M, Hata Y.. The mammalian Hippo pathway: regulation and function of YAP1 and TAZ. Cell Molecular Life Science. 2015; 72 285-306.

  40. Nagashma S, Kodaka M, Iwasa H, Hata Y.. MAGI2/S-SCAM outside brain. Journal of Biochemistry. 2015; 157 177-184.

  41. Lefebvre J, Clarkson M, Massa F, Bradford ST, Charlet A, Buske F, Lacas-Gervais S, Schulz H, Gimpel C, Hata Y, Schaefer F, Schedl A.. Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney International. 2015; 88 321-331.

  42. Kawano S, Maruyama J, Nagashima S, Inami K, Qiu W, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y.. A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells. Journal of Biochemistry. 2015; 158 413-423.

  43. Kodaka M, Yang Z, Nakagawa K, Maruyama J, Xu X, Sarkar A, Ichimura A, Nasu Y, Ozawa T, Iwasa H, Ishigami-Yuasa M, Ito S, Kagechika H, Hata Y.. A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells. Experimental Cell Research. 2015; 336 171-181.

  44. Iwasa H, Jiang X, Hata Y. . RASSF6; the Putative Tumor Suppressor of the RASSF Family. Cancers. 2015; 9 2415-2426.

  45. Kodaka M, Hata Y.. The mammalian Hippo pathway: regulation and function of YAP1 and TAZ. Cellular and molecular life sciences. 2015; 72 285-306. ( PubMed )

  46. Zeyu Yang, Kentaro Nakagawa, Aradhan Sarkar, Junichi Maruyama, Hiroaki Iwasa, Yijun Bao, Mari Ishigami-Yuasa, Shigeru Ito, Hiroyuki Kagechika, Shoji Hata, Hiroshi Nishina, Shinya Abe, Masanobu Kitagawa, Yutaka Hata. Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model. Mol. Cell. Biol.. 2014.05; 34 (9): 1607-1621. ( PubMed, DOI )

  47. Asuki Fukatsu, Futoshi Ishiguro, Ichidai Tanaka, Takumi Kudo, Kentaro Nakagawa, Keiko Shinjo, Yutaka Kondo, Makiko Fujii, Yoshinori Hasegawa, Kenji Tomizawa, Tetsuya Mitsudomi, Hirotaka Osada, Yutaka Hata, Yoshitaka Sekido. RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer. Lung Cancer. 2014.01; 83 (1): 23-29. ( PubMed, DOI )

  48. Hiroaki Iwasa, Takumi Kudo, Sainawaer Maimaiti, Mitsunobu Ikeda, Junichi Maruyama, Kentaro Nakagawa, Yutaka Hata. The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein. J. Biol. Chem.. 2013.10; 288 (42): 30320-30329. ( PubMed, DOI )

  49. Zeyu Yang, Yutaka Hata. What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans? J. Biochem.. 2013.09; 154 (3): 207-209. ( PubMed, DOI )

  50. Hiroaki Iwasa, Sainawaer Maimaiti, Hidehito Kuroyanagi, Shodai Kawano, Kazutoshi Inami, Shikshya Timalsina, Mitsunobu Ikeda, Kentaro Nakagawa, Yutaka Hata. Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans. Exp. Cell Res.. 2013.04; 319 (7): 931-945. ( PubMed, DOI )

  51. Yutaka Hata, Shikshya Timalsina, Sainawaer Maimaiti. Okadaic Acid: a tool to study the hippo pathway. Mar Drugs. 2013.03; 11 (3): 896-902. ( PubMed, DOI )

  52. Hiroaki Iwasa, Hidehito Kuroyanagi, Sainawaer Maimaiti, Mitsunobu Ikeda, Kentaro Nakagawa, Yutaka Hata. Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1. Exp. Cell Res.. 2013.02; 319 (3): 1-11. ( PubMed, DOI )

  53. Yohei Sanada, Takahiro Kumoto, Haruna Suehiro, Fusanori Nishimura, Norihisa Kato, Yutaka Hata, Alexander Sorisky, Noriyuki Yanaka. RASSF6 expression in adipocytes is down-regulated by interaction with macrophages. PLoS ONE. 2013; 8 (4): e61931. ( PubMed, DOI )

  54. Miki Nishio, Koichi Hamada, Kohichi Kawahara, Masato Sasaki, Fumihito Noguchi, Shuhei Chiba, Kensaku Mizuno, Satoshi O Suzuki, Youyi Dong, Masaaki Tokuda, Takumi Morikawa, Hiroki Hikasa, Jonathan Eggenschwiler, Norikazu Yabuta, Hiroshi Nojima, Kentaro Nakagawa, Yutaka Hata, Hiroshi Nishina, Koshi Mimori, Masaki Mori, Takehiko Sasaki, Tak W Mak, Toru Nakano, Satoshi Itami, Akira Suzuki. Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J. Clin. Invest.. 2012.12; 122 (12): 4505-4518. ( PubMed, DOI )

  55. Kanchanamala Withanage, Kentaro Nakagawa, Mitsunobu Ikeda, Hidetake Kurihara, Takumi Kudo, Zeyu Yang, Ayuko Sakane, Takuya Sasaki, Yutaka Hata. Expression of RASSF6 in kidney and the implication of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis in renal proximal tubular epithelial cells. J. Biochem.. 2012.07; 152 (1): 111-119. ( PubMed, DOI )

  56. Shoji Hata, Jun Hirayama, Hiroaki Kajiho, Kentaro Nakagawa, Yutaka Hata, Toshiaki Katada, Makoto Furutani-Seiki, Hiroshi Nishina. A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents. J. Biol. Chem.. 2012.06; 287 (26): 22089-22098. ( PubMed, DOI )

  57. Takumi Kudo, Mitsunobu Ikeda, Misa Nishikawa, Zeyu Yang, Kikuo Ohno, Kentaro Nakagawa, Yutaka Hata. The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53. Cancer Res.. 2012.06; 72 (11): 2901-2911. ( PubMed, DOI )

  58. Yijun Bao, Kentaro Nakagawa, Zeyu Yang, Mitsunobu Ikeda, Kanchanamala Withanage, Mari Ishigami-Yuasa, Yukiko Okuno, Shoji Hata, Hiroshi Nishina, Yutaka Hata. A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J. Biochem.. 2011.08; 150 (2): 199-208. ( PubMed, DOI )

  59. Yijun Bao, Yutaka Hata, Mitsunobu Ikeda, Kanchanamala Withanage. Mammalian Hippo pathway: from development to cancer and beyond. J. Biochem.. 2011.04; 149 (4): 361-379. ( PubMed, DOI )

  60. Masahiro Fukaya, Akifumi Kamata, Yoshinobu Hara, Hideaki Tamaki, Osamu Katsumata, Naoki Ito, Shin'ichi Takeda, Yutaka Hata, Tatsuo Suzuki, Masahiko Watanabe, Robert J Harvey, Hiroyuki Sakagami. SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses. J. Neurochem.. 2011.03; 116 (6): 1122-1137. ( PubMed, DOI )

  61. Lewis Kaufman, Uma Potla, Sarah Coleman, Stanislav Dikiy, Yutaka Hata, Hidetake Kurihara, John C He, Vivette D D'Agati, Paul E Klotman. Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis. J. Biol. Chem.. 2010.08; 285 (33): 25677-25685. ( PubMed, DOI )

  62. Kentaro Nakagawa, Misato Sugahara, Tokiwa Yamasaki, Hiroaki Kajiho, Shinya Takahashi, Jun Hirayama, Yasuhiro Minami, Yasutaka Ohta, Toshio Watanabe, Yutaka Hata, Toshiaki Katada, Hiroshi Nishina. Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation. Biochem. J.. 2010.04; 427 (2): 237-245. ( PubMed, DOI )

  63. Yijun Bao, Kazutaka Sumita, Takumi Kudo, Kanchanamala Withanage, Kentaro Nakagawa, Mitsunobu Ikeda, Kikuo Ohno, Yunjie Wang, Yutaka Hata. Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases. Genes Cells. 2009.12; 14 (12): 1369-1381. ( PubMed, DOI )

  64. Mitsunobu Ikeda, Akira Kawata, Misa Nishikawa, Yuko Tateishi, Masato Yamaguchi, Kentaro Nakagawa, Susumu Hirabayashi, Yijun Bao, Shiho Hidaka, Yukio Hirata, Yutaka Hata. Hippo pathway-dependent and -independent roles of RASSF6. Sci Signal. 2009; 2 (90): ra59. ( PubMed, DOI )

  65. S Hirabayashi, K Nakagawa, K Sumita, S Hidaka, T Kawai, M Ikeda, A Kawata, K Ohno, Y Hata. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. Oncogene. 2008.07; 27 (31): 4281-4292. ( PubMed, DOI )

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  70. Go Nagamatsu, Masako Ohmura, Takuo Mizukami, Isao Hamaguchi, Susumu Hirabayashi, Shosei Yoshida, Yutaka Hata, Toshio Suda, Kazuyuki Ohbo. A CTX family cell adhesion molecule, JAM4, is expressed in stem cell and progenitor cell populations of both male germ cell and hematopoietic cell lineages. Mol. Cell. Biol.. 2006.11; 26 (22): 8498-8506. ( PubMed, DOI )

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  73. Tokujiro Uchida, Madoka Shirasawa, Lorraine B Ware, Katsuo Kojima, Yutaka Hata, Koshi Makita, Gabe Mednick, Zachary A Matthay, Michael A Matthay. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am. J. Respir. Crit. Care Med.. 2006.05; 173 (9): 1008-1015. ( PubMed, DOI )

  74. Susumu Hirabayashi, Hiroki Mori, Ai Kansaku, Hidetake Kurihara, Tatsuo Sakai, Fujio Shimizu, Hiroshi Kawachi, Yutaka Hata. MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin. Lab. Invest.. 2005.12; 85 (12): 1528-1543. ( PubMed, DOI )

  75. Junko Iida, Susumu Hirabayashi, Yuji Sato, Yutaka Hata. Synaptic scaffolding molecule is involved in the synaptic clustering of neuroligin. Mol. Cell. Neurosci.. 2004.12; 27 (4): 497-508. ( PubMed, DOI )

  76. Hiroki Mori, Susumu Hirabayashi, Madoka Shirasawa, Haruhiko Sugimura, Yutaka Hata. JAM4 enhances hepatocyte growth factor-mediated branching and scattering of Madin-Darby canine kidney cells. Genes Cells. 2004.09; 9 (9): 811-819. ( PubMed, DOI )

  77. Susumu Hirabayashi, Wataru Nishimura, Junko Iida, Ai Kansaku, Shosei Kishida, Akira Kikuchi, Noriaki Tanaka, Yutaka Hata. Synaptic scaffolding molecule interacts with axin. J. Neurochem.. 2004.07; 90 (2): 332-339. ( PubMed, DOI )

  78. Madoka Shirasawa, Naoyuki Fujiwara, Susumu Hirabayashi, Hideki Ohno, Junko Iida, Koshi Makita, Yutaka Hata. Receptor for advanced glycation end-products is a marker of type I lung alveolar cells. Genes Cells. 2004.02; 9 (2): 165-174. ( PubMed )

  79. Hideki Ohno, Susumu Hirabayashi, Ai Kansaku, Ikuko Yao, Makiko Tajima, Wataru Nishimura, Hirohide Ohnishi, Hirosato Mashima, Toshiro Fujita, Masao Omata, Yutaka Hata. Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains. Oncogene. 2003.11; 22 (52): 8422-8431. ( PubMed, DOI )

  80. Makiko Tajima, Susumu Hirabayashi, Ikuko Yao, Madoka Shirasawa, Junichi Osuga, Shun Ishibashi, Toshiro Fujita, Yutaka Hata. Roles of immunoglobulin-like loops of junctional cell adhesion molecule 4; involvement in the subcellular localization and the cell adhesion. Genes Cells. 2003.09; 8 (9): 759-768. ( PubMed )

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▼全件表示

書籍等出版物 【 表示 / 非表示

  1. Xu X, Kodaka M, Iwasa H, Hata Y. Encyclopedia of Signaling Molecules MAGI2/S-SCAM. SPringer, MAGI2

  2. Kodaka M, Xu X, Yang X,Maruyama J, Hata Y. SPringer Protocol Appication of split-GFP reassembly assay to the study of the in vitro myogenesis and myofusion.. Springer, Application of split-GFP reassembly assay to the study of the in vitro myogenesis and myofusion.

  3. Iwasa H, Shimizu T, Hata Y.. Encyclopedia of Signaling Molecules RASSF6. Springer, RASSF6 (ISBN : 978-1-4419-0460-7)

講演・口頭発表等 【 表示 / 非表示

  1. Yutaka Hata. New tricks that regulate YAP and TAZ. Telluride Science Research Center Workshop 2019.06.12 Telluride, Collardo, USA

  2. Hossain Shakhawoat, 岩佐宏晃, 畑裕. RASSF6腫瘍抑制タンパク質は網膜芽細胞腫タンパク質を介してアポトーシスと細胞周期を制御する. 第77回日本癌学会総会 2018.09

  3. 松崎 京子, 畑 裕. ストレス顆粒形成を抑制する化合物によるがん細胞の抗がん剤感受性への影響. 日本癌学会総会記事 2017.09.01

  4. Yutaka Hata. Transcriptional coactivator with PDZ-binding motif (TAZ), a potential target for interventions against muscle-wasting disorders. Neuroscience Symposium 2015 2015.10.23

  5. 長島 俊太, 丸山 順一, 岩佐 宏晃, 有本-松崎 京子, 本田 香織, 近藤 恭光, 長田 裕之, 名和 眞希子, 石上-湯浅 磨里, 影近 弘之, 中浜 健一, 仁科 博史, 畑 裕 . ケミカルバイオロジーからアプローチしたTAZの新しい制御機構の解析 . 第41回日本分子生物学会年会 2018.11.30 横浜

  6. 畑 裕. がん治療、再生医療の治療標的としての 転写共役因子YAP1、TAZの有用性について. 第38回日本分子生物学会年会・第88回日本生化学会大会・合同大会 2015.12.03 神戸

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特許 【 表示 / 非表示

  • 筋形成促進剤、筋萎縮抑制剤、医薬組成物及びTAZ活性化剤

    特許番号: US10653672

 

担当授業科目(学内) 【 表示 / 非表示

  • 生化学