基本情報

写真a

池田 正明(イケダ マサアキ)

IKEDA Masaaki


職名

非常勤講師

研究室住所

〒113-8549 東京都文京区湯島1-5-45

研究室電話番号

03-5803-5579

研究室FAX番号

03-5803-0213

メールアドレス

mikeda.emb@tmd.ac.jp

ホームページ

http://ikeda-emb-tmd.hp.infoseek.co.jp/

研究分野・キーワード

遺伝子発現調節, 細胞増殖, 細胞死, 組織再生, 終末分化, 核内高次構造, 癌抑制遺伝子, 発がん, 細胞の可塑性

出身学校 【 表示 / 非表示

  • 東京医科歯科大学  歯学部  1983年  卒業

出身大学院 【 表示 / 非表示

  • 東京医科歯科大学  歯学研究科  基礎歯科学系歯科薬理学  博士課程  1987年  修了

取得学位 【 表示 / 非表示

  • 歯学博士  東京医科歯科大学

経歴(学内) 【 表示 / 非表示

  • 1987年09月
    -
    2018年03月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 顎顔面頸部機能再建学講座 分子発生学 准教授
  • 2018年04月
    -
    2022年03月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 顎顔面頸部機能再建学講座 分子発生学 准教授
  • 2022年04月
    -
    現在
    東京医科歯科大学 大学院医歯学総合研究科 医歯学専攻 生体支持組織学講座 硬組織構造生物学分野 非常勤講師

経歴(学外) 【 表示 / 非表示

  • 東京医科歯科大学歯学部顎口腔研究施設顎顔面発生機構研究部門助手1987年9月〜1988年8月、
  • 同歯学部口腔細菌学教室助手 1988年9月〜1992年3月、
  • 同大学院生体機能制御歯科学系発生機構制御学講座講師 1992年4月〜1996年11月、
  • デューク大学医学部ハワードヒューズ医学研究所研究員 1991年8月〜1994年8月、
  • 東京医科歯科大学大学院生体機能制御歯科学系発生機構制御学講座助教授 1996年12月〜1999年3月、
  • 同大学院医歯学総合研究科分子発生学分野助教授 1999年4月〜2007年3月、同准教授 2007年4月
  • 1987-1988
  • Research Associate, Section of Craniofacial Development and Anomalies, Institute of Stomatognathic Science, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
  • 1988-1992
  • Research Associate, Department of Oral Microbiology, Faculty of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
  • 1991-1994
  • Research associate, Department of Genetics, Howard Hughes Medical Institute, Duke University Medical Center, North Carolina, USA
  • 1992-1996
  • Lecturer, Department of Developmental Biology, Graduate School of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
  • 1996-2000
  • Associate Professor, Department of Developmental Biology, Graduate School of Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
  • 2000-present
  • Associate Professor, Section of Molecular Embryology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

▼全件表示

所属学協会 【 表示 / 非表示

  • 日本分子生物学会

  • 日本再生医療学会

  • 歯科基礎医学会

  • 日本口腔外科学会

  • 日本癌学会

  • 日本生化学会

  • 口腔病学会

▼全件表示

委員歴 【 表示 / 非表示

  • 2008年
    -
    現在
    歯科基礎医学会 評議員
  • 2002年
    -
    現在
    口腔病学会 評議員

研究分野 【 表示 / 非表示

  • 分子生物学

  • 細胞生物学

  • 口腔再生医学、歯科医用工学

  • 常態系口腔科学

  • 病態系口腔科学

 

研究テーマ 【 表示 / 非表示

  • 間葉幹細胞を用いた硬組織再生,2012年04月 - 現在

  • ヒト線維芽細胞から骨・軟骨細胞への直接分化転換,2008年04月 - 現在

  • 癌抑制に関与する転写制御機構と口腔癌における制御異常,1994年08月 - 現在

競争的資金等の研究課題 【 表示 / 非表示

  • 直接分化転換によるヒト成人皮膚・口腔粘膜細胞からの再生歯誘導の試み

    文部科学省/日本学術振興会 : 2015年 - 2017年

  • ヒト線維芽細胞から骨・軟骨細胞への直接分化転換と硬組織再生への応用

    文部科学省/日本学術振興会 : 2014年 - 2016年

  • インスレーターの解除による細胞のリプログラミングと骨細胞への直接分化転換の試み

    文部科学省/日本学術振興会 : 2012年 - 2014年

  • ノックアウトマウスによる脳エストロゲンの骨代謝制御機構の研究

    文部科学省/日本学術振興会

  • 生殖腺を欠く遺伝子破壊マウスを利用した脳の性分化分子機構の研究

    文部科学省/日本学術振興会

  • 未分化脂肪幹細胞の移植による軟骨内骨化を介した骨形成法と新しい骨再生療法への応用

    文部科学省/日本学術振興会

  • 骨折治癒過程をモデルにした骨欠損部の血流不足を改善させる新たな骨再生法の開発

    文部科学省/日本学術振興会

▼全件表示

論文・総説 【 表示 / 非表示

  1. Saadat KASM, Lestari W, Pratama E, Ma T, Iseki S, Tatsumi M, Ikeda MA. Distinct and overlapping roles of ARID3A and ARID3B in regulating E2F‑dependent transcription via direct binding to E2F target genes. International journal of oncology. 2021.04; 58 (4): ( PubMed, DOI )

  2. Arman Kaifee, Saadat Khandakar A. S. M., Igci Yusuf Z., Bozgeyik Esra, Ikeda Masa-Aki, Cakmak Ecir A., Arslan Ahmet. Long noncoding RNA ERICD interacts with ARID3A via E2F1 and regulates migration and proliferation of osteosarcoma cells CELL BIOLOGY INTERNATIONAL. 2020.08; 11434 ( PubMed, DOI )

  3. 3. Bozgeyik E, Saadat KASM, Arman K, Bozgeyik I, Ikeda MA. Enhanced E2F1 activity increases invasive and proliferative activity of breast cancer cells through non-coding RNA CDKN2B-AS1 Meta Gene. 2020.06; 24 100691. ( DOI )

  4. 2. Saadat KASM, Bozgeyik E, Arman K, Bozgeyik I, Ikeda MA. ARID3A-mediated modulation of TP73 and TP73-AS1 in osteosarcoma cells Gene Reports. 2020.04; 20 100683. ( DOI )

  5. Nobuo Tsuchida, Masa-Aki Ikeda, Υoshizumu Ιshino, Michele Grieco, Giancarlo Vecchio. FUCA1 is induced by wild-type p53 and expressed at different levels in thyroid cancers depending on p53 status. International Journal of Oncoloy. 2017.06; 50 (6): 2043-2048. ( PubMed, DOI )

  6. Endrawan Pratama, Xiaohui Tian, Widya Lestari, Sachiko Iseki, Solachuddin J A Ichwan, Masa-Aki Ikeda. Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis. Biochem. Biophys. Res. Commun.. 2015.12; 468 (1-2): 248-254. ( PubMed, DOI )

  7. Yayoi Ikeda, Masa-Aki Ikeda. Cyclin E marks quiescent neural stem cells and caspase-3-positive newborn cells during adult hippocampal neurogenesis in mice. Neurosci. Lett.. 2015.10; 607 90-96. ( PubMed, DOI )

  8. Eri Tsuchida, Atsushi Kaida, Endrawan Pratama, Masa-Aki Ikeda, Keiji Suzuki, Kiyoshi Harada, Masahiko Miura. Effect of X-Irradiation at Different Stages in the Cell Cycle on Individual Cell-Based Kinetics in an Asynchronous Cell Population. PLoS ONE. 2015; 10 (6): e0128090. ( PubMed, DOI )

  9. Solachuddin J A Ichwan, Imad M Al-Ani, Hakim G Bilal, Wastuti H Suriyah, Muhammad Taher, Masa-Aki Ikeda. Apoptotic activities of thymoquinone, an active ingredient of black seed (Nigella sativa), in cervical cancer cell lines. Chin J Physiol. 2014.10; 57 (5): 249-255. ( PubMed, DOI )

  10. Yuniardini S Wimardhani, Dewi F Suniarti, Hans J Freisleben, Septelia I Wanandi, Nurjati C Siregar, Masa-Aki Ikeda. Chitosan exerts anticancer activity through induction of apoptosis and cell cycle arrest in oral cancer cells. J Oral Sci. 2014.06; 56 (2): 119-126. ( PubMed )

  11. Auerkari E I, Joewono V, Handjari D R, Sarwono A T, Suhartono A W, Eto K, Ikeda M A. Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients. Open Dent J. 2014; 8 136-143. ( PubMed, DOI )

  12. Young Min Chung, See-Hyoung Park, Wen-Bin Tsai, Shih-Ya Wang, Masa-Aki Ikeda, Jonathan S Berek, David J Chen, Mickey C-T Hu. FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage. Nat Commun. 2012.08; 3 1000. ( PubMed, DOI )

  13. Wimardhani SY, Sunia DF, Freisleben H-J, Septelia Wanandi SI, Ikeda MA. Cytotoxic effect of chitosan against oral cancer cell lines is molecular-weight-dependent and cell-type-specific. Int. J. Oral Res. 2012.04; 3 e1.

  14. Teng Ma, Shumpei Yamada, Solachuddin J A Ichwan, Sachiko Iseki, Kiyoshi Ohtani, Megumi Otsu, Masa-Aki Ikeda. Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation. Biochem. Biophys. Res. Commun.. 2012.01; 417 (3): 931-937. ( PubMed, DOI )

  15. Widya Lestari, Solachuddin J A Ichwan, Megumi Otsu, Shumpei Yamada, Sachiko Iseki, Shihoko Shimizu, Masa-Aki Ikeda. Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage. Biochem. Biophys. Res. Commun.. 2012.01; 417 (2): 710-716. ( PubMed, DOI )

  16. Yayoi Ikeda, Yuko Matsunaga, Masahito Takiguchi, Masa-Aki Ikeda. Expression of cyclin E in postmitotic neurons during development and in the adult mouse brain. Gene Expr. Patterns. 2011.01; 11 (1-2): 64-71. ( PubMed, DOI )

  17. Juan Liu, Hiroshi Uematsu, Nobuo Tsuchida, Masa-Aki Ikeda. Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol. Cancer. 2011; 10 95. ( PubMed, DOI )

  18. Liu J, Uematsu H, Tsuchida N, Ikeda MA. Association of caspase-8 mutation with chemoresistance to cisplatin in HOC313 head and neck squamous cell carcinoma cells. Biochem Biophys Res Commun. 2009.12; 390 (3): 989-994. ( PubMed, DOI )

  19. Ichwan SJA, Ikeda MA. Defect in Ser46 Phosphorylation of p53 Protein: A Resistance Mechanism against p53 Gene Transfer in Oral Squamous Cell Carcinoma Cells . J Oral Biosci. 2009.10; 50 (2): 98-106. ( DOI )

  20. Murugan AK, Hong NT, Cuc TT, Hung NC, Munirajan AK, Ikeda MA, Tsuchida N. Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer. Oral Oncol. 2009.10; 45 (10): e161-6. ( PubMed, DOI )

  21. Althunibat OY, Hashim, RB, Taher M, Daud JM, Ikeda MA, Zali BI. n Vitro Antioxidant and Antiproliferative Activities of Three Malaysian Sea Cucumber Species. European Journal of Scientific Research . 2009.04; (37): 376-387.

  22. Ozono E, Komori H, Iwanaga R, Ikeda MA, Iseki S, Ohtani K. E2F-like elements in p27(Kip1) promoter specifically sense deregulated E2F activity. Genes Cells. 2009.01; 14 (1): 89-99. ( PubMed, DOI )

  23. Suganuma T, Ikeda MA. Tumor Growth Suppression by the Coactivator p300 . J Oral Biosci. 2008.10; 50 (2): 115-124. ( DOI )

  24. Iwanaga R, Ozono E, Fujisawa J, Ikeda MA, Okamura N, Huang Y, Ohtani K. Activation of the cyclin D2 and cdk6 genes through NF-kappaB is critical for cell-cycle progression induced by HTLV-I Tax. Oncogene. 2008.05; ( PubMed, DOI )

  25. Katsuki Y, Sakamoto K, Minamizato T, Makino H, Umezawa A, Ikeda MA, Perbal B, Amagasa T, Yamaguchi A, Katsube K. Inhibitory effect of CT domain of CCN3/NOV on proliferation and differentiation of osteogenic mesenchymal stem cells, Kusa-A1. Biochem Biophys Res Commun. 2008.04; 368 (3): 808-814. ( PubMed, DOI )

  26. Ichwan, SJA, Ikeda MA. Defect in Ser46 Phosphorylation of p53 Protein: A Resistance Mechanism against p53 Gene Transfer in Oral Squamous Cell Carcinoma Cells. J. Oral Biosci.. 2008; 50 (2): 98-106.

  27. Nakajima Y, Yamada S, Kamata N, Ikeda MA. Interaction of E2F-Rb family members with corepressors binding to the adjacent E2F site. Biochem Biophys Res Commun. 2007.12; 364 (4): 1050-1055. ( PubMed, DOI )

  28. Bhawal UK, Sugiyama M, Nomura Y, Sawajiri M, Tsukinoki K, Ikeda MA, Kuniyasu H. High-risk human papillomavirus type 16 E7 oncogene associates with Cdc25A over-expression in oral squamous cell carcinoma. Virchows Arch. 2007.01; 450 (1): 65-71. ( PubMed, DOI )

  29. Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA. Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. Oncogene. 2006.02; 25 (8): 1216-1224. ( PubMed, DOI )

  30. Sumrejkanchanakij P, Eto K, Ikeda MA. Cytoplasmic sequestration of cyclin D1 associated with cell cycle withdrawal of neuroblastoma cells. Biochem Biophys Res Commun. 2006.02; 340 (1): 302-308. ( PubMed, DOI )

  31. Bhawal UK, Ozaki Y, Nishimura M, Sugiyama M, Sasahira T, Nomura Y, Sato F, Fujimoto K, Sasaki N, Ikeda MA, Tsuji K, Kuniyasu H, Kato Y. Association of expression of receptor for advanced glycation end products and invasive activity of oral squamous cell carcinoma. Oncology. 2005; 69 (3): 246-255. ( PubMed, DOI )

  32. Yamada S, Sumrejkanchanakij P, Amagasa T, Ikeda MA. Loss of cyclin E requirement in cell growth of an oral squamous cell carcinoma cell line implies deregulation of its downstream pathway. Int J Cancer. 2004.08; 111 (1): 17-22. ( PubMed, DOI )

  33. Nonomura Y, Kohsaka H, Nagasaka K, Miyasaka N. Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis. J Immunol. 2003.11; 171 (9): 4913-4919. ( PubMed )

  34. Ikeda Y, Nagai A, Ikeda MA, Hayashi S. Sexually dimorphic and estrogen-dependent expression of estrogen receptor beta in the ventromedial hypothalamus during rat postnatal development. Endocrinology. 2003.11; 144 (11): 5098-5104. ( PubMed, DOI )

  35. Sumrejkanchanakij P, Tamamori-Adachi M, Matsunaga Y, Eto K, Ikeda MA. Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons. Oncogene. 2003.11; 22 (54): 8723-8730. ( PubMed, DOI )

  36. Araki K, Nakajima Y, Eto K, Ikeda MA. Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression of the E2F1 promoter. Oncogene. 2003.10; 22 (48): 7632-7641. ( PubMed, DOI )

  37. Ma K, Araki K, Ichwan SJ, Suganuma T, Tamamori-Adachi M, Ikeda MA. E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53. Mol Cancer Res. 2003.04; 1 (6): 438-444. ( PubMed )

  38. Nagai A, Ikeda Y, Aso T, Eto K, Ikeda MA. Exposure of neonatal rats to diethylstilbestrol affects the expression of genes involved in ovarian differentiation. J Med Dent Sci. 2003.03; 50 (1): 35-40. ( PubMed )

  39. Tamamori-Adachi M, Ito H, Sumrejkanchanakij P, Adachi S, Hiroe M, Shimizu M, Kawauchi J, Sunamori M, Marumo F, Kitajima S, Ikeda MA. Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res. 2003.01; 92 (1): e12-9. ( PubMed )

  40. Suganuma T, Kawabata M, Ohshima T, Ikeda MA. Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator. Proc Natl Acad Sci U S A. 2002.10; 99 (20): 13073-13078. ( PubMed, DOI )

  41. Tamamori-Adachi M, Ito H, Nobori K, Hayashida K, Kawauchi J, Adachi S, Ikeda MA, Kitajima S. Expression of cyclin D1 and CDK4 causes hypertrophic growth of cardiomyocytes in culture: a possible implication for cardiac hypertrophy. Biochem Biophys Res Commun. 2002.08; 296 (2): 274-280. ( PubMed )

  42. 29. Gao CF, Ren S, Wang J, Zhang SL, Jin F, Nakajima T, Ikeda MA, Tsuchida N. . P130 and its truncated form mediate p53-induced cell cycle arrest in Rb-/- Saos2 cells. Oncogene. 2002.04; (21): 7569-7579.

  43. Ikeda Y, Nagai A, Ikeda MA, Hayashi S. Increased expression of Mullerian-inhibiting substance correlates with inhibition of follicular growth in the developing ovary of rats treated with E2 benzoate. Endocrinology. 2002.01; 143 (1): 304-312. ( PubMed )

  44. Ikeda Y, Nagai A, Ikeda MA, Hayashi S. Neonatal estrogen exposure inhibits steroidogenesis in the developing rat ovary. Dev Dyn. 2001.08; 221 (4): 443-453. ( PubMed, DOI )

  45. Zhang YW, Morita I, Ikeda M, Ma KW, Murota S. Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. Oncogene. 2001.07; 20 (31): 4138-4149. ( PubMed, DOI )

  46. Nonomura Y, Kohsaka H, Nasu K, Terada Y, Ikeda M, Miyasaka N. Suppression of arthritis by forced expression of cyclin-dependent kinase inhibitor p21(Cip1) gene into the joints. Int Immunol. 2001.06; 13 (6): 723-731. ( PubMed )

  47. Adachi S, Ito H, Tamamori-Adachi M, Ono Y, Nozato T, Abe S, Ikeda Ma, Marumo F, Hiroe M. Cyclin A/cdk2 activation is involved in hypoxia-induced apoptosis in cardiomyocytes. Circ Res. 2001.03; 88 (4): 408-414. ( PubMed )

  48. Matsui M, Ikeda M, Akatsuka T. High expression of HLA-A2 on an oral squamous cell carcinoma with down-regulated transporter for antigen presentation. Biochem Biophys Res Commun. 2001.02; 280 (4): 1008-1014. ( PubMed, DOI )

  49. Ohshima T, Suganuma T, Ikeda M. A novel mutation lacking the bromodomain of the transcriptional coactivator p300 in the SiHa cervical carcinoma cell line. Biochem Biophys Res Commun. 2001.02; 281 (2): 569-575. ( PubMed, DOI )

  50. Ohtani K, Iwanaga R, Nakamura M, Ikeda M, Yabuta N, Tsuruga H, Nojima H. Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. Oncogene. 1999.04; 18 (14): 2299-2309. ( PubMed, DOI )

  51. Tamamori M, Ito H, Hiroe M, Terada Y, Marumo F, Ikeda MA. Essential roles for G1 cyclin-dependent kinase activity in development of cardiomyocyte hypertrophy. Am J Physiol. 1998.12; 275 (6 Pt 2): H2036-40. ( PubMed )

  52. Ota M, Eto K, Ninomiya Y, Ikeda M. Accumulation of p300 mediates transcriptional repression of simian virus 40 enhancer in undifferentiated F9 embryonal carcinoma cells. Cell Growth Differ. 1998.12; 9 (12): 989-997. ( PubMed )

  53. Ohtani K, Tsujimoto A, Ikeda M, Nakamura M. Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F. Oncogene. 1998.10; 17 (14): 1777-1785. ( PubMed, DOI )

  54. Chareonvit S, Osumi-Yamashita N, Ikeda M, Eto K. Murine forebrain and midbrain crest cells generate different characteristic derivatives in vitro. Dev Growth Differ. 1997.08; 39 (4): 493-503. ( PubMed )

  55. Ikeda MA, Jakoi L, Nevins JR. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc Natl Acad Sci U S A. 1996.04; 93 (8): 3215-3220. ( PubMed )

  56. Ikeda MA, Nevins JR. Identification of distinct roles for separate E1A domains in disruption of E2F complexes. Mol Cell Biol. 1993.11; 13 (11): 7029-7035. ( PubMed )

  57. Yamada S, Ikeda MA, and Eto, K.. Differential Expression of c-myc and N-myc during Oral Organogenesis of the Mouse Embryo. Dev. Growth Differ.. 1992; (34): 239-251.

  58. Nakajima H, Ikeda M, Tsuchida N, Nishimura S, Taya Y. Inactivation of the N-myc gene product by single amino acid substitution of leucine residues located in the leucine-zipper region. Oncogene. 1989.08; 4 (8): 999-1002. ( PubMed )

  59. Suzuki Y, Hidari K, Matsumoto M, Ikeda M, Tsuchida N. Altered ganglioside expression in ras-oncogene-transformed cells. J Biochem. 1989.07; 106 (1): 34-37. ( PubMed )

  60. Ikeda M, Tsuchida N. Myc genes linked to viral promoters can collaborate with a transformation-deficient simian virus 40 early gene mutant to transform established rat cells. Jpn J Cancer Res. 1987.05; 78 (5): 428-431. ( PubMed )

  61. Zhang K, Ikeda Y, Kasugai S, Ikeda MA. Extended Culture Conditions for Multipotent Bone Marrow-Derived Mesenchymal Stem Cells 口腔病学会雑誌. 2016.03; 83 (1): 13-23.

  62. 池田正明. 口腔癌におけるp53遺伝子導入抵抗性獲得の分子機構 口腔病学会雑誌. 2006; 73 (1): 139.

  63. 池田正明. 増えない細胞の細胞周期研究 —組織再生と細胞死— 2004; 22 (13): 1820-1824.

  64. 池田正明. RB蛋白質 炎症と免疫. 2003; (8): 122-123.

  65. 池田正明、安達三美. サイクリンD1の核移行制御と心筋細胞の増殖 実験医学. 2003; 21 (5): 37-42.

  66. 池田正明. 転写因子E2F-RBファミリーとDNA腫瘍ウイルスのターゲット 転写因子E2Fと細胞増殖制御 実験医学. 1995; (13): 126-131.

  67. 丸山光男、和賀祥、和田忠志、池田正明、松本健蛋白質核酸酵素. DNA腫瘍ウイルスの分子生物学の現状 蛋白質核酸酵素. 1994; (39): 252-261.

  68. 佐竹正延、池田正明、沢田幸治、和田忠士、村上康文. SV40, ポリオーマ、アデノウイルスの分子生物学ー最近の動向 蛋白質核酸酵素. 1991; (36): 910-918.

  69. 大谷清、池田正明. 転写因子E2Fと細胞増殖制御 蛋白質核酸酵素. 1987.04; 42 (10): 1603-1611.

▼全件表示

書籍等出版物 【 表示 / 非表示

  1. Ichwan SJA, Bakhtiar MT, Ohtani K, Ikeda MA. Therapeutic Targeting of p53-Mediated Apoptosis Pathway in Head and Neck Squamous Cell Carcinomas:. 2012.02

  2. Distinct transcriptional regulation by E2F in cell growth and tumor suppression. "Control of cellular physiology by the transcription factor E2F" p91-105. Research Signpost, 2008 (ISBN : 978-81-308-0230-5)

  3. Collaborative Transformation with Two Oncogenes; myc Colloaborating with v-src in primary Cells & with an Immortalization-Positive SV40 Mutated Oncogene in Established rat Cells. "Recent Progress of Life Science Technology in Japan" p119-136. Academic Press, 1989

  4. 増えない細胞の細胞周期研究 —組織再生と細胞死- 実験医学 Vol.22 No.13 p. 1820-1824. 羊土社, 2004 (ISBN : 9784897068282)

  5. 心筋の増殖停止機構 「発生における細胞増殖制御」 p101-109. シュプリンガー・フェアラーク東京, 2004 (ISBN : 978-4-431-71031-8)

  6. 細胞の増殖制御と癌化 「キーワードで理解する転写イラストマップ」 p176 –193. 羊土社, 2004 (ISBN : 9784897065793)

  7. サイクリンD1の核移行制御と心筋細胞の増殖 実験医学、Vol.21, No.5 (増刊), p37-42. 羊土社, 2003 (ISBN : 9784897060965)

  8. Bタンパク質と転写因子E2Fによる細胞周期の制御機構 「わかる細胞周期と癌」 p28-36 ISBN : 9784897065755. 羊土社, 2000

  9. Bタンパク質と転写因子E2Fによる細胞周期の制御機構 「わかる細胞周期と癌 田矢洋一編」 p28-36. 羊土社, 2000 (ISBN : 9784897065755)

  10. 新しい発光システムを応用したマルチレポーターアッセイ — ルシフェラーゼアッセイによる転写活性測定法とその応用 「脱アイソトープ実戦プロトコール(2)」 p334-346. 秀潤社, 1998 (ISBN : 87962-181-1)

  11. 転写因子E2Fと細胞増殖制御 蛋白質 核酸 酵素 (増刊) Vol. 42 No. 10 p1603-1611. 共立出版, 1997

▼全件表示

講演・口頭発表等 【 表示 / 非表示

  1. Khandakar A.S.M. Saadat, Widya Lestari, Teng Ma, Endrawan Pratama, Sachiko Iseki, Kiyoshi Ohtani, Masa-Aki Ikeda. ARID3B modulates E2F target gene expression and cell proliferation.. 2019年度生命科学系学会合同年次大会 2019.12.04 福岡

  2. Saadat K ASM, Ikeda MA. Gene-Silencing Efficiency Determination of ARID3B in Osteosarcoma Cell Lines by siRNA and shRNA. 6th International Multidisciplinary Studies Congress 2019.04.26 Gaziantep, Turkey

  3. Saadat K ASM, Ikeda MA. Gene-Silencing Efficiency Determination of ARID3B in Osteosarcoma Cell Lines by siRNA and shRNA. III. International Eurasia Multidisciplinary Studies Congress 2019.04.04 Gaziantep, Turkey

  4. Öğr. Üyesi. Saadat K ASM. Saadat, Arman K, Ikeda MA. ARID3A Regulates the Tumor Suppressor Tap73 in Osteosarcoma. 2nd ZEUGMA International Congress on Multidisciplinary Studies 2019.01.20 Gaziantep Turkey

  5. Saadat K ASM, Arman K, Ikeda MA. ARID3A Regulates the Tumor Suppressor Tap73 in Osteosarcoma. 2nd ZEUGMA International Congress on Multidisciplinary Studies 2019.01.18 Gaziantep Turkey

  6. Saadat K ASM, Arman K, Ikeda MA. ARID3A Directly Regulates Autophagy Related Gene Beclġn1 in Osteosarcoma. 2nd ZEUGMA International Congress on Multidisciplinary Studies 2019.01.18 Gaziantep Turkey

  7. Arman K, Saadat K ASM, Altan Z, Sahin Y, Ikeda MA, Igci M. Opposite roles of lncRNA ERICD and ARID3A in DNA damage-induced apoptosis. 5th World Congress on Epigenetics and Chromosome 2018.11.15

  8. Altan Z, Şahin Y, Yassin AR, Ikeda MA, Saadat K ASM. The Interaction betweeen LncRNA MEG3 and its Target, miR-203, in Bladder Cancer. International Eurasian Conference on Biological and Chemical Sciences 2018.04.26 Ankara, Turkey

  9. Xiaohui Tian、Shohei Kasugai、Masa-Aki Ikeda. Investigation of culture conditions for enhancing the proliferation and osteogenic differentiation potential of adipose-derived stem cells. 2017年度生命科学系学会合同年次大会 2017.12.07

  10. 3. Nobuo Tsuchida, Alessia Parascandolo, Masa-Aki Ikeda, Maria D Castellone, Giancarloa Vecchio. p53-inducible FUCA1 attenuates aggressiveness of thyroid and breast cancers. 第76回日本癌学会学術総会 2017.09.28

  11. Amani KANJO , Kaifee ARMAN , Ahmet ARSLAN , Sibel Oğuzkan BALCI , Masa-Aki IKEDA , Khandakar A S M SAADAT. ARID3A Directly Regulates AKT1 But Not PTEN In Osteosarcoma. 1st International Congress on Cancer & Ion Channels 2017.09.21

  12. Bozgeyik I, Çakmak EA, Saadat KASM, Ikeda MA, Igci M. Microtubule Associated Scaffold Protein 1 (MTUS1) is A Candidate Tumor Suppressor in Breast Cancer. VI. International Congress of Molecular Medicine 2017.05.22

  13. Ikeda MA. Novel Candidates of Therapeutic Targets for Head and Neck Squamous Cell Carcinomas Defined by Recent Comprehensive Mutation Analysis . The 17th Scientific and Refresher Course in Dentistry (KPPIKG 2016) 2016.02.27 Jakarta, Indonesia

  14. Endrawan Pratama, Khandakar A S M Saadat,Widya Lestari,Solachuddin J. A. Ichwan, Sachiko Iseki, Kiyoshi Ohtani,Masa-Aki Ikeda. ARID3B promotes gene expression critical for E2f-mediated cell cycle progression and p53-mediated apotosis. Biochemistry and Molecular Biology (BMB2015) 2015.12.01 Kobe

  15. Saadat Khandakar Asm, Arman Kaifee, Arslan Ahmet, Sachiko Iseki, Kiyoshi Ohtani, Masa-Aki Ikeda. Expression study of E2F-target genes in osteosarcoma (U2OS) and glioblastoma (T98G) cell lines after knocking down ARID3A and ARID3B. XIV. National Congress of Medical Biology and Genetics 2015.10.27 Fethiye, Turkey

  16. Saadat Khandakar Asm, Arman Kaifee, Arslan Ahmet, Kiyoshi Ohtani, Masa-Aki Ikeda. Overexpression of ARID3 facilitates E2F-dependent apoptosis. XIV. National Congress of Medical Biology and Genetics 2015.10.27

  17. Ikeda, MA. Simple and efficient long-term culture method to maintain multipotent differentiation potential of mesenchymal stem/stromal cells. Seminar 2015.03.27 Kuantan, Malaysia

  18. Ikeda Y, Ikeda MA. Immunohistochemical detection of cyclin E in non-proliferating neurons of the mouse adult hippocampal dentate gyrus. Society for Neuroscience 2014 Annual Meeting 2014.11.17

  19. Ikeda, MA. Mesenchymal Stem Cells and Bone Tissue Engineering - Overview and Our Approach –. Regional Oral Biology Scientific Meeting 2014 2014.10.30

  20. 山崎新太郎,清水 真優,井関 祥子,依田 哲也,池田 正明. 軟骨内骨化を介した骨再生に適したヒト間葉系幹細胞の培養条件および足場材料の検討. 第42回日本炎症・再生医学会 2021.07.07 東京

  21. Saadat KASM,Pratama E, Lestari W,Ma T, Ohtani K,Ikeda MA. Critical role of ARID3B in the expression of E2F-responsive genes and cell proliferation. 第39回日本分子生物学会年会 2016.12.01 横浜

  22. Zhang K, Kasugai S, Ikeda MA. Maintenance of Stemness in Mesenchymal Stem Cells during Long-Term Culture. 第79回口腔病学会学術大会 2014.12.06

  23. Pratama E, Iseki S, Ikeda MA. Critical roles for ARID3B in Expression of Proapoptotic p53-Target Genes and Cell Death Following DNA Damage. 第 37回日本分子生物学会年会 2014.11.26

  24. Endrawan Pratama、井関祥子、池田正明. アポトーシス関連p53標的遺伝子の発現と細胞死誘導におけるDNA結合因子ARID3Bの重要な役割. 第56回歯科基礎医学会学術大会 2014.09.13

▼全件表示

特許 【 表示 / 非表示

  • 終末分化細胞の増殖方法及びそのための組み換えベクター

    特許番号: PCT・JP01/08208

受賞学術賞 【 表示 / 非表示

  • 病態代謝研究会研究助成,2003年

その他業績 【 表示 / 非表示

  • 癌化のメカニズム,1985年04月

    Medical Tribune

 

担当授業科目(学内) 【 表示 / 非表示

  • 人体の発生 「初期発生」「形態形成の分子機構と先天異常」,2000年 - 現在

  • 航空組織・発生学 実習,2016年 - 現在

  • 組織学各論 実習,2016年 - 現在

  • 組織学総論 実習,2016年 - 現在