Personnel Information

写真a

TAKAGI Yuzo


Job title

Professor(Moving Out or Retirement)

Laboratory Address

1-5-45,Yushima, Bunkyo-ku, Tokyo 113-8549, Japan

Laboratory Phone number

+81-3-5803-5539
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Graduating School 【 display / non-display 】

  • Niigata University, Faculty of Dentistry, School of Denristry, 1972, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Dental Research, Pediatric Dentistry, Doctor's Course, 1978, Completed

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Campus Career 【 display / non-display 】

  • 1900.01
    -
    2012.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Pediatric Dentistry， Professor
  • 2021.12
    -
    Now
    Tokyo Medical and Dental University， Professor
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External Career 【 display / non-display 】

  • 1978-1979 Instructor in the Department of Pediatric Dentistry, Dental Hospital, Tokyo,
  • Medical and Dental University,
  • 1979-1982 Assistant Professor in the Department of Pediatric Dentistry, School of Dentistry,,
  • Tokyo Medical and Dental University,
  • 1980-1982 Visiting Instructor in the Department of Oral Biology, Northwestern University,
  • Dental School, Chicago, USA,
  • 1983-1997 Associate Professor in the Department of Pediatric Dentistry, School of Dentistry,,
  • Tokyo Medical and Dental University,
  • 1997-2000 Professor and Chairman of the Department of Pediatric Dentistry, School of,
  • Dentistry, Tokyo Medical and Dental University,
  • 1997- Director of Pediatric Dentistry, Dental Hospital, Tokyo Medical and Dental,
  • University,
  • 2000- Professor and Chairman of the Division of Developmental Oral Health Sciences,,
  • Graduate School, Tokyo Medical and Dental University,

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Academic Society Affiliations 【 display / non-display 】

  • International Association for Dental Research, Sigma Xi, The Scientific Research Society

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Academic Activity 【 display / non-display 】

  • Vice Dean, School of Dentistry, Tokyo Medical and Dental University
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Research Areas 【 display / non-display 】

  • Developmental dentistry

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Published Papers & Misc 【 display / non-display 】

  1. Y. Nakajima, Y. Shimada, A. Sadr, I. Wada, M. Miyashin, Y. Takagi, J. Tagami, Y. Sumi. Detection of occlusal caries in primary teeth using swept source optical coherence tomography. Journal of Biomedical Optics. 2014.01; 19 (1):

  2. K. Shoi, K. Aoki, K. Ohya, Y. Takagi, H. Shimokawa. Characterization of stem cells from impacted supernumerary maxillary incisors. Pediatric Dentistry. 2014; 36 (3): 79-84.

  3. A. Ohishi. T. Terashima, M. Miyashin, Y. Takagi. Repair processes of experimental root fractures in rat molars examined by histopathological techniques and 3D micro-CT imaging. Pediatric Dental Journal . 2013; 23 8-15.

  4. N. Tsuchihashi, N. Uehara, Y. Takagi, Z. Miwa, K. Sugimoto. Internal stress in children and parental attitude to dental treatment with passive restraint. Pediatric Dental Journal. 2012; 22 (2): 170-177.

  5. A. Ohira, Y. Ono, N. Yano, Y. Takagi. The effect of chewing exercise in preschool children on maximum bite force and masticatory performance International Journal of Paediatric Dentistry. 2012; 22 146-153.

  6. N. Uehara, Y. Takagi, Z. Miwa, K. Sugimoto. Objective assessment of internal stress in children during dental treatment by analysis of autonomic nervous activity. International Journal of Paediatric Dentistry . 2012; 22 (5): 331-341.

  7. S. Ishidro, Y. Ono, Y. Takagi. Craniofacial growth changes in children with severe incisal tooth wear. Pediatric Dental Journal. 2012; 22 43-49.

  8. Y. Imamura, M. Nakamura, A. Nagai, Y. Takagi, K. Yamashita. Octacalcium phosphate-mediated cement as a root canal filling material for primary teeth. Phosphorus Research Bulletin. 2012; 26 33-38.

  9. Y. Nakajima, Y. Shimada, M. Miyashin, Y. Takagi, J. Tagami, Y. Sumi. Noninvesive cross-sectional imaging of imperfect crown fractures (cracks) using swept-source optical coherence tomography. International Endodontic Journal. 2012; 45 (10): 933-941.

  10. S. Ohba, W. Wang, S. Itoh, Y. Takagi, A. Nagai, K. Yamashita. Acceleration of new bone formation by the electrically polarized hydroxyapatite micro-granules/platelet-rich plasma composite. S. Ohba, W. Wang, S. Itoh, Y. Takagi, A. Nagai, K. Yamashita. 2012; 8 (7): 2778-2787.

  11. K. Wada, M. Miyashin, N. Nango, Y. Takagi. Wear characteristics of resin composites and deciduous enamels: Determination of the applicability of resin composites to full crown restoration of deciduous molars. American Journal of Dentistry. 2011; 24 67-73.

  12. Imamura Y, Tanaka Y, Nagai A, Yamashita K, Takagi Y. Self-sealing ability of OCP-mediated cement as a deciduous root canal filling materia. Dent Mater J. 2010.10; 29 (5): 582-588. ( PubMed )

  13. N. Isokawa, S. Ochiai, T. Mito, N. Ishibashi, J. Kindaichi, M. Ishikawa, Y. Takagi. Three-dimensional comparison in palatal forms between the Modified Pre-surgical Nasoalveolar Molding Plate and the Hotz Plate applied to the infants with unilateral cleft lip and palate. Singapore Dental Journal. 2010; 31 (1): 1-7.

  14. Sriarj W, Aoki K, Ohya K, Takagi Y, Shimokawa H. Bovine dentine organic matrix down-regulates osteoclast activity. J Bone Miner Metab. 2009; 27 (3): 315-323. ( PubMed, DOI )

  15. Kakino S, Takagi Y, Takatani S. Absolute transmitted light plethysmography for assessment of dental pulp vitality through quantification of pulp chamber hematocrit by a three-layer model. J Biomed Opt. 2008.09; 13 (5): 54023. ( PubMed, DOI )

  16. Techawattanawisal W, Nakahama K, Komaki M, Abe M, Takagi Y, Morita I. Isolation of multipotent stem cells from adult rat periodontal ligament by neurosphere-forming culture system. Biochem Biophys Res Commun. 2007.06; 357 (4): 917-923. ( PubMed, DOI )

  17. Motegi M, Takagi Y, Yonezawa H, Hanada N, Terajima J, Watanabe H, Senpuku H. Assessment of genes associated with Streptococcus mutans biofilm morphology. Appl Environ Microbiol. 2006.09; 72 (9): 6277-6287. ( PubMed, DOI )

  18. Tung K, Fujita H, Yamashita Y, Takagi Y. Effect of turpentine-induced fever during the enamel formation of rat incisor. Arch Oral Biol. 2006.06; 51 (6): 464-470. ( PubMed, DOI )

  19. Linsuwanont-Santiwong B, Takagi Y, Ohya K, Shimokawa H. Expression of MT1-MMP during deciduous tooth resorption in odontoclasts. J Bone Miner Metab. 2006; 24 (6): 447-453. ( PubMed, DOI )

  20. Varghese BJ, Aoki K, Shimokawa H, Ohya K, Takagi Y. Bovine deciduous dentine is more susceptible to osteoclastic resorption than permanent dentine: results of quantitative analyses. J Bone Miner Metab. 2006; 24 (3): 248-254. ( PubMed, DOI )

  21. Kirimoto A, Takagi Y, Ohya K, Shimokawa H. Effects of retinoic acid on the differentiation of chondrogenic progenitor cells, ATDC5. J Med Dent Sci. 2005.09; 52 (3): 153-162. ( PubMed )

  22. Tonami K, Takahashi H, Kato J, Nakano F, Nishimura F, Takagi Y, Kurosaki N. Effects of laser irradiation on tensile strength of bovine dentin. Photomed Laser Surg. 2005.06; 23 (3): 278-283. ( PubMed, DOI )

  23. Umeda M, Miwa Z, Takeuchi Y, Ishizuka M, Huang Y, Noguchi K, Tanaka M, Takagi Y, Ishikawa I. The distribution of periodontopathic bacteria among Japanese children and their parents. J Periodontal Res. 2004.12; 39 (6): 398-404. ( PubMed, DOI )

  24. Sena M, Yamashita Y, Nakano Y, Ohgaki M, Nakamura S, Yamashita K, Takagi Y. Octacalcium phosphate-based cement as a pulp-capping agent in rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004.06; 97 (6): 749-755. ( PubMed, DOI )

  25. Isogawa N, Terashima T, Nakano Y, Kindaichi J, Takagi Y, Takano Y. The induction of enamel and dentin complexes by subcutaneous implantation of reconstructed human and murine tooth germ elements. Arch Histol Cytol. 2004.03; 67 (1): 65-77. ( PubMed )

  26. Angelova A, Takagi Y, Okiji T, Kaneko T, Yamashita Y. Immunocompetent cells in the pulp of human deciduous teeth. Arch Oral Biol. 2004.01; 49 (1): 29-36. ( PubMed )

  27. Miwa Z, Ikawa M, Iijima H, Saito M, Takagi Y. Pulpal blood flow in vital and nonvital young permanent teeth measured by transmitted-light photoplethysmography: a pilot study. Pediatr Dent. 2002.11; 24 (6): 594-598. ( PubMed )

  28. Linsuwanont B, Takagi Y, Ohya K, Shimokawa H. Expression of matrix metalloproteinase-9 mRNA and protein during deciduous tooth resorption in bovine odontoclasts. Bone. 2002.10; 31 (4): 472-478. ( PubMed )

  29. Oueis H, Ono Y, Takagi Y. Prediction of mandibular growth in Japanese children age 4 to 9 years. Pediatr Dent. 2002.05; 24 (3): 264-268. ( PubMed )

  30. Yamazoe T, Aoki K, Simokawa H, Ohya K, Takagi Y. Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp. J Med Dent Sci. 2002.03; 49 (1): 57-66. ( PubMed )

  31. Linsuwanont B, Takagi Y, Ohya K, Shimokawa H. Localization of cathepsin K in bovine odontoclasts during deciduous tooth resorption. Calcif Tissue Int. 2002.02; 70 (2): 127-133. ( PubMed, DOI )

  32. Teng NC, Nakamura S, Takagi Y, Yamashita Y, Ohgaki M, Yamashita K. A new approach to enhancement of bone formation by electrically polarized hydroxyapatite. J Dent Res. 2001.10; 80 (10): 1925-1929. ( PubMed )

  33. Melo L, Ono Y, Takagi Y. Indicators of mandibular dental crowding in the mixed dentition. Pediatr Dent. 2001.03; 23 (2): 118-122. ( PubMed )

  34. Jayawardena JA, Kato J, Moriya K, Takagi Y. Pulpal response to exposure with Er:YAG laser. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001.02; 91 (2): 222-229. ( PubMed, DOI )

  35. Ohma N, Takagi Y, Takano Y. Distribution of non-collagenous dentin matrix proteins and proteoglycans, and their relation to calcium accumulation in bisphosphonate-affected rat incisors. Eur J Oral Sci. 2000.06; 108 (3): 222-232. ( PubMed )

  36. Fuangtharnthip P, Yamada Y, Takagi Y, Ohya K. Autoradiographic investigation of the effect of 1-hydroxyethylidene-1, 1-bisphosphonate on matrix protein synthesis and secretion by secretory ameloblasts in rat incisors. Arch Oral Biol. 2000.06; 45 (6): 495-506. ( PubMed )

  37. Thotakura SR, Mah T, Srinivasan R, Takagi Y, Veis A, George A. The non-collagenous dentin matrix proteins are involved in dentinogenesis imperfecta type II (DGI-II). J Dent Res. 2000.03; 79 (3): 835-839. ( PubMed )

  38. Yamada Y, Fuangtharnthip P, Tamura Y, Takagi Y, Ohya K. Gene expression and immunolocalization of amelogenin in enamel hypoplasia induced by successive injections of bisphosphonate in rat incisors. Arch Oral Biol. 2000.03; 45 (3): 207-215. ( PubMed )

  39. Goseki-Sone M, Orimo H, Iimura T, Miyazaki H, Oda K, Shibata H, Yanagishita M, Takagi Y, Watanabe H, Shimada T, Oida S. Expression of the mutant (1735T-DEL) tissue-nonspecific alkaline phosphatase gene from hypophosphatasia patients. J Bone Miner Res. 1998.12; 13 (12): 1827-1834. ( PubMed, DOI )

  40. Takagi Y, Fujita H, Katano H, Shimokawa H, Kuroda T. Immunochemical and biochemical characteristics of enamel proteins in hypocalcified amelogenesis imperfecta. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998.04; 85 (4): 424-430. ( PubMed )

  41. Goseki-Sone M, Orimo H, Iimura T, Takagi Y, Watanabe H, Taketa K, Sato S, Mayanagi H, Shimada T, Oida S. Hypophosphatasia: identification of five novel missense mutations (G507A, G705A, A748G, T1155C, G1320A) in the tissue-nonspecific alkaline phosphatase gene among Japanese patients. Hum Mutat. 1998; Suppl 1 S263-7. ( PubMed )

  42. Takagi Y, Kindaichi J, Moriyama K, Suzuki M, Shimokawa H, Sasaki S. Distribution of alpha 2HS glycoprotein in pathological human dentins. Connect Tissue Res. 1994; 30 (4): 309-321. ( PubMed )

  43. Okamura T, Shimokawa H, Takagi Y, Ono H, Sasaki S. Detection of collagenase mRNA in odontoclasts of bovine root-resorbing tissue by in situ hybridization. Calcif Tissue Int. 1993.04; 52 (4): 325-330. ( PubMed )

  44. Miyashin M, Kato J, Takagi Y. Tissue reactions after experimental luxation injuries in immature rat teeth. Endod Dent Traumatol. 1991.02; 7 (1): 26-35. ( PubMed )

  45. Goseki M, Oida S, Takagi Y, Okuyama T, Watanabe J, Sasaki S. Immunological study on hypophosphatasia. Clin Chim Acta. 1990.10; 190 (3): 263-268. ( PubMed )

  46. Takagi Y, Shimokawa H, Suzuki M, Nagai H, Sasaki S. Immunohistochemical localization of alpha 2HS glycoprotein in dentin. Calcif Tissue Int. 1990.07; 47 (1): 40-45. ( PubMed )

  47. Miyashin M, Kato J, Takagi Y. Experimental luxation injuries in immature rat teeth. Endod Dent Traumatol. 1990.06; 6 (3): 121-128. ( PubMed )

  48. Takagi Y, Nagai H, Sasaki S. Difference in noncollagenous matrix composition between crown and root dentin of bovine incisor. Calcif Tissue Int. 1988.02; 42 (2): 97-103. ( PubMed )

  49. Takagi Y, Sasaki S. Histological distribution of phosphophoryn in normal and pathological human dentins. J Oral Pathol. 1986.10; 15 (9): 463-467. ( PubMed )

  50. Takagi Y, Fujisawa R, Sasaki S. Identification of dentin phosphophoryn localization by histochemical stainings. Connect Tissue Res. 1986; 14 (4): 279-292. ( PubMed )

  51. Miwa Z, Tanaka M, Kunizawa S, Takagi Y. [Dental characteristics of a patient with I-cell disease (mucolipidosis II)]. Shoni Shikagaku Zasshi. 1985; 23 (1): 233-242. ( PubMed )

  52. Takagi Y, Veis A. Isolation of phosphophoryn from human dentin organic matrix. Calcif Tissue Int. 1984.05; 36 (3): 259-265. ( PubMed )

  53. Takagi Y, Veis A, Sauk JJ. Relation of mineralization defects in collagen matrices to noncollagenous protein components. Identification of a molecular defect in dentinogenesis imperfecta. Clin Orthop Relat Res. 1983.06; (176): 282-290. ( PubMed )

  54. Takagi Y, Koshiba H, Kimura O, Kuboki Y, Sasaki S. Dentinogenesis imperfecta: evidence of qualitative alteration in the organic dentin matrix. J Oral Pathol. 1980.07; 9 (4): 201-209. ( PubMed )

  55. Takagi Y, Kuboki Y, Sasaki S. Detection of collagen degradation products from subcutaneously implanted organic bone matrix. Calcif Tissue Int. 1979.11; 28 (3): 253-258. ( PubMed )

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