Ao X, Yang Y, Okiji T, Azuma M, Nagai S.. Polymorphonuclear Myeloid-derived cells that contribute to the immune paralysis are generated in the early phase of sepsis via PD-1/PD-L1 pathway. Infection and Immunity. 2021.05; 89 (6): e00771-20. ( PubMed, DOI )

Azuma T, Sato Y, Ohno T, Azuma M, Kume H. Serum soluble B7-H3 is a prognostic marker for patients with non-muscle-invasive bladder cancer. PloS one. 2020.12; 15 (12): e0243379. ( PubMed, DOI )

Yang Y, Nagai S, Kang S, Xia Y, Kawano Y, Miyake K, Karasuyama H, Azuma M. Tolerogenic properties of CD206⁺ macrophages appeared in the sublingual mucosa after repeated antigen-painting. International Immunology . 2020.07; 32 (8): 509-518. ( PubMed, DOI )

J Rodriguez-Barbosa, Azuma M, Zelinskyy G, J Perez-Simon, M Del Rio. Critical role of PD-L1 expression on non-tumor cells rather than on tumor cells for effective anti-PD-L1 immunotherapy in a transplantable mouse hematopoietic tumor model. Cancer Immunol Immunother. 2020.06; 69 (6): 1001-1014. ( PubMed, DOI )

Kashima Y, Nishii N, Tachinami H, Furusawa E, Nagai S, Harada H, Azuma M. Orthotopic tongue squamous cell carcinoma (SCC) model exhibiting a different tumor-infiltrating T-cell status with margin-restricted CD8⁺ T cells and regulatory T cell-dominance, compared to skin SCC. Biochem. Biophys. Res. Commun.. 2020.05; 526 (1): 218-224. ( PubMed, DOI )

Eri Ikeda, Takahiko Shiba, Yuichi Ikeda, Wataru Suda, Akinori Nakasato, Yasuo Takeuchi, Miyuki Azuma, Masahira Hattori, Yuichi Izumi. Japanese subgingival microbiota in health vs disease and their roles in predicted functions associated with periodontitis. Odontology. 2020.04; 108 (2): 280-291. ( PubMed, DOI )

Kunishige T, Taniguchi H, Ohno T, Azuma M, Hori J. VISTA is crucial for corneal allograft survival and maintenance of immune privilege. Invest Ophthalmol Vis Sci. 2019.12; 60 (15): 4958-4965. ( PubMed, DOI )

Nagai S, Azuma M. The CD28-B7 family of co-signaling molecules. Adv Exp Med Biol.. 2019.11; 1189 25-51. ( PubMed, DOI )

Azuma M. Co-signal molecules in T-cell activation : Historical overview and perspective. Adv Exp Med Biol.. 2019.11; 1189 3-23. ( PubMed, DOI )

Furusawa E, Ohno T, Nagai S, Noda T, Komiyama T, Kobayashi K, Hamamoto H, Miyashin M, Yokozeki H, Azuma M. Silencing of PD-L2/B7-DC by topical application of small interfering RNA inhibits elicitation of contact hypersensitivity. J Invest Dermatol. 2019.10; 139 (10): 2164-2173. ( PubMed, DOI )

Xia Y, Ohno T, Nishii N, Bhingare A, Tachinami H, Kashima Y, Nagai S, Saito H, Nakae S, Azuma M. T cell antitumor responses overcoming pro-tumor effects by regulatory T cells in a colon carcinoma model. Biochem Biophys Res Commun. 2019.10; 518 (2): 331-336. ( PubMed, DOI )

Vu CTB, Thammahong A, Yagita H, Azuma M, Hirankarn N, Ritprajak P, Leelahavanichkul A. Blockade of PD-1 attenuated post-sepsis aspergillosis via the activation of IFN-γ and the dampening of IL-10. Shock. 2019.07; 11 ( PubMed, DOI )

Furusawa Emi, Ohno Tatsukuni, Nagai Shigenori, Noda Taisei, Komiyama Takuya, Kobayashi Katsunori, Hamamoto Hidetoshi, Miyashin Michiyo, Yokozeki Hiroo, Azuma Miyuki. Silencing of PD-L2/B7-DC by Topical Application of Small Interfering RNA Inhibits Elicitation of Contract Hypersensitivity JOURNAL OF IMMUNOLOGY. 2019.05; 202 (1):

Tachinami H, Nishii N, Xia Y, Kashima Y, Ohno T, Nagai S, Li L, Lau W, Tomihara K, Noguchi M, Azuma M. Differences of tumor-recruiting myeloid cells in murine squamous cell carcinoma influence the efficacy of immunotherapy combined with a TLR7 agonist and PD-L1 blockade. Oral Oncol.. 2019.04; 91 21-28. ( PubMed, DOI )

Copland A, Sparrow A, Hart P, Diogo GR, Paul M, Azuma M, Reljic R. Bacillus calmette-guérin induces PD-L1 expression on antigen-presenting cells via autocrine and paracrine interleukin-STAT3 circuits. Sci Rep. 2019.03; 9 (1): 3655. ( PubMed, DOI )

Ikeda E, Shiba T, Ikeda Y, Suda W, Nakasato A, Takeuchi Y, Azuma M, Hattori M, Izumi Y. Deep sequencing reveals specific bacterial signatures in the subgingival microbiota of healthy subjects. Clin Oral Investig. 2019.03; 23 (3): 1489-1493. ( PubMed, DOI )

Mulati K, Hamanishi J, Matsumura N, Chamoto K, Mise N, Abiko K, Baba T, Yamaguchi K, Horikawa N, Murakami R, Taki M, Budiman K, Zeng X, Hosoe Y, Azuma M, Konishi I, Mandai M. VISTA expressed in tumour cells regulates T cell function. Br J Cancer. 2019.01; 120 (1): 115-127. ( PubMed, DOI )

Murat K, Hamanishi J, Matsumura N, Chamoto K, Mise N, Abiko K, Baba T, Yamaguchi K, Murakami R, Hosoe Y, Azuma M, Konishi I, Mandai M. VISTA expressed in tumor cells regulates T cell function Cancer Science. 2018.12; 109 1323.

Azuma T, Sato Y, Ohno T,Azuma M, Kume H.. Serum soluble B7-H4 is a prognostic marker for patients with non –metastatic clear cell renal cell carcinoma. Plos One. 2018.07; 13 (7): e01997119. ( DOI )

Furusawa E., Ohno T., Miyashin M., Azuma M.. Topical application of B7-DC/PD-L2 siRNA inhibits contact hypersensitivity EUROPEAN JOURNAL OF IMMUNOLOGY. 2018.05; 48 52-53.

Nishii N., Tachinami H., Kondo Y., Xia Y., Kashima Y., Ohno T., Nagai S., Li L., Lau W., Harada H., Azuma M.. Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy EUROPEAN JOURNAL OF IMMUNOLOGY. 2018.05; 48 71-72.

Nishii N, Tachinami H, Kondo Y, Xia Y, Kashima Y, Ohno T, Nagai S, Li L, Lau W, Harada H, Azuma M. Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy. Oncotarget. 2018.03; 9 (17): 13301-13312. ( PubMed, DOI )

Ohno T, Zhang C, Kondo Y, Kang S, Furusawa E, Tsuchiya K, Miyazaki Y, Azuma M. The immune checkpoint molecule VISTA regulates allergen-specific Th2-mediated immune responses. Int Immune. 2018.02; 30 (1): 3-11. ( PubMed, DOI )

Azuma T, Sato Y, Ohno T, Azuma M, Kume H. Serum soluble B7-H4 is a prognostic marker for patients with non-metastatic clear cell renal cell carcinoma. PloS one. 2018; 13 (7): e0199719. ( PubMed, DOI )

Swangphon P, Pientong C, Sunthamala N, Bumrungthai S, Azuma M, Kleebkaow P, Tangsiriwatthana T, Sangkomkamhang U, Kongyingyoes B, Ekalaksananan T. Correlation of circulating CD64⁺/CD63⁺ monocyte ratio and stroma/peri-tumoral CD163⁺ monocyte density with human papillomavirus infected cervical lesion severity. Cancer Microenvironment. 2017.12; 10 (1-3): 77-85. ( PubMed, DOI )

Sugita J, Asada Y, Ishida W, Iwamoto S, Sudo K, Suto H, Matsunaga T, Fukuda K, Fukushima A, Yokoi N, Ohno T, Azuma M, Ebihara N, Saito H, Kubo M, Nakae S, Matsuda A. Contributions of interleukin-33 and TSLP in a papain-soaked contact lens-induced mouse conjunctival inflammation model. Immun Inflamm Dis. 2017.12; 5 (4): 515-525. ( PubMed, DOI )

Nagai Shigenori, Adiba Nadya Niken, Tezuka Hiroyuki, Ohteki Toshiaki, Matsuda Satoshi, Azuma Miyuki. PI3K-Akt pathway enhances Tr1 differentiation induced by IL-27 CYTOKINE. 2017.12; 100 173.

Nadya NA, Tezuka H, Ohteki T, Matsuda S, Azuma M, Nagai S. PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells. Immunology. 2017.11; 152 (3): 507-516. ( PubMed, DOI )

Hirunwidchayarat W, Furusawa E, Kang S, Ohno T, Takeuchi S, Rungsiyanont S, Azuma M. Site-specific regulation of oral mucosa-recruiting CD8^＋ T cells in a mouse contact allergy model. Biochem Biophys Res Commun. 2017.09; 490 (4): 1294-1300. ( PubMed, DOI )

De Riva A, Wallberg M, Ronchi F, Coulson R, Sage A, Thorne L, Goodfellow L, McCoy K, Azuma M, Cooke A, Busch R. Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment. Plos One. 2017.08; 12 (8): e0181964. ( PubMed, DOI )

Wallberg M, Recino A, Phillips J, Howie D, Vienne M, Paluch C, Azuma M, Wong FS, Waldmann H, Cooke A. Anti-CD3 treatment up-regulates programmed cell death protein-1 expression on activated effector T cells and severely impairs their inflammatory capacity. Immunology. 2017.06; 151 (2): 248-260. ( PubMed, DOI )

Ohno T, Kondo Y, Zhang C, Kang S, Azuma M. Immune checkpoint molecule, VISTA regulates T cell-mediated skin inflammatory responses. J Invest Dermatol . 2017.06; 137 (6): 1384-1386. ( PubMed, DOI )

Taniguchi Hiroko, Hase Hidenori, Akiba Hisaya, Yagita Hideo, Azuma Miyuki, Hori Junko. Role of B7-H3/TLT-2 pathway in immune privilege of corneal allografts INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2017.06; 58 (8):

Kang S, Zhang C, Ohno T, Azuma M. Unique B7-H1 expression on masticatory mucosae in the oral cavity and trans-coinhibition by B7-H1-expressing keratinocytes regulating CD4⁺ T-cell-mediated mucosal tissue inflammation. Mucosal Immunol. 2017.05; 10 (3): 650-660. ( PubMed, DOI )

Kang S., Zhang C., Ohno T., Azuma M.. Unique B7-H1 expression on masticatory mucosae in the oral cavity and trans-coinhibition by B7-H1-expressing keratinocytes regulating CD4(+) T cell-mediated mucosal tissue inflammation MUCOSAL IMMUNOLOGY. 2017.05; 10 (3): 650-660. ( DOI )

Vo M, Holz LE, Wong YC, English K, Benseler V, McGuffog C, Azuma M, McGaughan GW, Bowen DG, Bertolino P. Effector T cell function rather than survival determines extent and duration of hepatitis in mice. J Hapatol. 2016; 64 1327-1338.

Kurebayashi Y, Baba Y, Minowa A, Nadya NA, Azuma M, Yoshimura A, Koyasu S, Nagai S. TGF-β-induced phosphorylation of akt and foxo transcription factors negatively regulates the differentiation of induced regulatory T cells. Biochem Biophys Res Commun. 2016; 480 (1): 114-119. ( DOI )

Kondo Y, Ohno T, Nishii N, Harada K, Yagita H, Azuma M. Differential contribution of three immune checkpoint (VISTA, CTLA-4, PD-1) pathways to antitumor responses against squamous cell carcinoma. Oral Oncology. 2016; 57 54-60. ( DOI )

Ooi JD, Li M, Kourkoutzelos K, Yagita H, Azuma M, Holdsworth SR, Kitching AR. Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis. Nephrology (Carlton). 2015.12; 20 (12): 892-898. ( PubMed, DOI )

Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S. An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory T cell numbers Immunity. 2015.07; 43 (1): 175-186. ( PubMed )

McAlees JW, Lajoie S, Dienger K, Sproles AA, Richgels PK, Yang Y, Khodoun M, Azuma M, Yagita H, Fulkerson PC, Wills-Karp M, Lewkowich IP. Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma. Eur. J. Immunol. 2015.04; 45 (4): 1019-1029. ( PubMed, DOI )

Patcharee R, Azuma M. Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. Oral Oncol. 2015.03; 51 (3): 221-228. ( PubMed )

Zhang C, Ohno T, Kang S, Takai T, Azuma M. Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets. Vaccine. 2014.09; 32 (43): 5669-5676. ( PubMed, DOI )

Fujiwara H, Maeda Y, Kobayashi K, Nishimori H, Matsuoka K, Fujii N, Kondo E, Tanaka T, Chen L, Azuma M, Yagita H, Tanimoto M. Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease. J. Immunol. 2014.09; 193 (5): 2565-2573. ( PubMed, DOI )

Sunthamala N, Pientong C, Ohno T, Zhang C, Bhingare AC, Kondo Y, Azuma M, Ekalaksananan T. HPV16 E2 protein promotes innate immunity by modulating immunosuppressive status. Biochem. Biophys. Res. Commun.. 2014.04; 446 (4): 977-982. ( PubMed, DOI )

Bhingare AC, Ohno T, Tomura M, Zhang C, Aramaki O, Otsuki M, Tagami J, Azuma M. Dental pulp dendritic cells migrate to regional lymph nodes. J. Dent. Res.. 2014.03; 93 (3): 288-293. ( PubMed, DOI )

Asim Saha, Kazutoshi Aoyama, Patricia A Taylor, Brent H Koehn, Rachelle G Veenstra, Angela Panoskaltsis-Mortari, David H Munn, William J Murphy, Miyuki Azuma, Hideo Yagita, Brian T Fife, Mohammed H Sayegh, Nader Najafian, Gerard Socie, Rafi Ahmed, Gordon J Freeman, Arlene H Sharpe, Bruce R Blazar. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood. 2013.10; 122 (17): 3062-3073. ( PubMed, DOI )

Kristen E Pauken, Marc K Jenkins, Miyuki Azuma, Brian T Fife. PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes. Diabetes. 2013.08; 62 (8): 2859-2869. ( PubMed, DOI )

Nienke van der Werf, Stephen A Redpath, Miyuki Azuma, Hideo Yagita, Matthew D Taylor. Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection. PLoS Pathog.. 2013.03; 9 (3): e1003215. ( PubMed, DOI )

Benjamin Joachim Schmiedel, Tina Nuebling, Julia Steinbacher, Alexandra Malinovska, Constantin Maximilian Wende, Miyuki Azuma, Pascal Schneider, Ludger Grosse-Hovest, Helmut Rainer Salih. Receptor activator for NF-κB ligand in acute myeloid leukemia: expression, function, and modulation of NK cell immunosurveillance. J. Immunol.. 2013.01; 190 (2): 821-831. ( PubMed, DOI )

Benjamin Joachim Schmiedel, Carolin Andrea Scheible, Tina Nuebling, Hans-Georg Kopp, Stefan Wirths, Miyuki Azuma, Pascal Schneider, Gundram Jung, Ludger Grosse-Hovest, Helmut Rainer Salih. RANKL expression, function, and therapeutic targeting in multiple myeloma and chronic lymphocytic leukemia. Cancer Res.. 2013.01; 73 (2): 683-694. ( PubMed, DOI )

Takuya Ueno, Melissa Y Yeung, Martina McGrath, Sunmi Yang, Nadia Zaman, Benjamin Snawder, Robert F Padera, Ciara N Magee, Rostic Gorbatov, Masaaki Hashiguchi, Miyuki Azuma, Gordon J Freeman, Mohamed H Sayegh, Nader Najafian. Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses. Eur. J. Immunol.. 2012.09; 42 (9): 2343-2353. ( PubMed, DOI )

Takeshi Isoda, Masatoshi Takagi, Jinhua Piao, Shun Nakagama, Masaki Sato, Kyoko Masuda, Tomokatsu Ikawa, Miyuki Azuma, Tomohiro Morio, Hiroshi Kawamoto, Shuki Mizutani. Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM. Blood. 2012.07; 120 (4): 789-799. ( PubMed, DOI )

Tadashi Yokosuka, Masako Takamatsu, Wakana Kobayashi-Imanishi, Akiko Hashimoto-Tane, Miyuki Azuma, Takashi Saito. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J. Exp. Med.. 2012.06; 209 (6): 1201-1217. ( PubMed, DOI )

186. Hashiguchi M, Inamochi Y, Nagai S, Otsuki N, Piao J, Kobori H, Kanno Y, Kojima H, Kobata T, Azuma M.. Human B7-H3 binds to Triggering receptor expressed on myeloid cells-like transcript 2 (TLT-2) and enhances T cell responses. 2012.02; 2 (1): 9-16. ( DOI )

Patcharee Ritprajak, Masaaki Hashiguchi, Hisaya Akiba, Hideo Yagita, Ko Okumura, Miyuki Azuma. Antibodies against B7-DC with differential binding properties exert opposite effects. Hybridoma (Larchmt). 2012.02; 31 (1): 40-47. ( PubMed, DOI )

Francesca D'Addio, Leonardo V Riella, Bechara G Mfarrej, Lola Chabtini, La Tonya Adams, Melissa Yeung, Hideo Yagita, Miyuki Azuma, Mohamed H Sayegh, Indira Guleria. The link between the PDL1 costimulatory pathway and Th17 in fetomaternal tolerance. J. Immunol.. 2011.11; 187 (9): 4530-4541. ( PubMed, DOI )

Stephen A Newland, Jenny M Phillips, Pietro Mastroeni, Miyuki Azuma, Paola Zaccone, Anne Cooke. PD-L1 blockade overrides Salmonella typhimurium-mediated diabetes prevention in NOD mice: no role for Tregs. Eur. J. Immunol.. 2011.10; 41 (10): 2966-2976. ( PubMed, DOI )

Jang-Jaer Lee, Yen-Liang Chang, Wan-Ling Lai, Jenq-Yuh Ko, Mark Yen-Ping Kuo, Chun-Pin Chiang, Miyuki Azuma, Ching-Wen Chen, Jean-San Chia. Increased prevalence of interleukin-17-producing CD4(+) tumor infiltrating lymphocytes in human oral squamous cell carcinoma. Head Neck. 2011.09; 33 (9): 1301-1308. ( PubMed, DOI )

Oto Aramaki, Narumon Chalermsarp, Masayuki Otsuki, Junji Tagami, Miyuki Azuma. Differential expression of co-signal molecules and migratory properties in four distinct subsets of migratory dendritic cells from the oral mucosa. Biochem. Biophys. Res. Commun.. 2011.09; 413 (3): 407-413. ( PubMed, DOI )

Jun Yang, Leonardo V Riella, Susanne Chock, Tao Liu, Xiaozhi Zhao, Xueli Yuan, Alison M Paterson, Toshihiko Watanabe, Vijay Vanguri, Hideo Yagita, Miyuki Azuma, Bruce R Blazar, Gordon J Freeman, Scott J Rodig, Arlene H Sharpe, Anil Chandraker, Mohamed H Sayegh. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J. Immunol.. 2011.08; 187 (3): 1113-1119. ( PubMed, DOI )

Nienke van der Werf, Stephen A Redpath, Alexander T Phythian-Adams, Miyuki Azuma, Judith E Allen, Rick M Maizels, Andrew S Macdonald, Matthew D Taylor. Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo. J. Immunol.. 2011.08; 187 (3): 1411-1420. ( PubMed, DOI )

Yujia Cao, Lu Zhang, Pacharee Ritprajak, Fumihiko Tsushima, Pornpan Youngnak-Piboonratanakit, Yosuke Kamimura, Masaaki Hashiguchi, Miyuki Azuma. Immunoregulatory molecule B7-H1 (CD274) contributes to skin carcinogenesis. Cancer Res.. 2011.07; 71 (14): 4737-4741. ( PubMed, DOI )

Koichiro Matsumoto, Keiko Kan-O, Miyuki Eguchi-Tsuda, Satoru Fukuyama, Yukari Asai, Takafumi Matsumoto, Atsushi Moriwaki, Yuko Matsunaga, Hiroko Tsutsui, Taro Kawai, Osamu Takeuchi, Shizuo Akira, Hideo Yagita, Miyuki Azuma, Yoichi Nakanishi, Hiromasa Inoue. Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice. Am. J. Respir. Cell Mol. Biol.. 2011.07; 45 (1): 31-39. ( PubMed, DOI )

Emily Hams, Mark J McCarron, Sylvie Amu, Hideo Yagita, Miyuki Azuma, Lieping Chen, Padraic G Fallon. Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells. J. Immunol.. 2011.05; 186 (10): 5648-5655. ( PubMed, DOI )

Fredy R S Gutierrez, Flávia S Mariano, Carlo J F Oliveira, Wander R Pavanelli, Paulo M M Guedes, Grace K Silva, Ana P Campanelli, Cristiane M Milanezi, Miyuki Azuma, Tasuku Honjo, Mauro M Teixeira, Julio C S Aliberti, João S Silva. Regulation of Trypanosoma cruzi-induced myocarditis by programmed death cell receptor 1. Infect. Immun.. 2011.05; 79 (5): 1873-1881. ( PubMed, DOI )

Qing Zhou, Meghan E Munger, Rachelle G Veenstra, Brenda J Weigel, Mitsuomi Hirashima, David H Munn, William J Murphy, Miyuki Azuma, Ana C Anderson, Vijay K Kuchroo, Bruce R Blazar. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood. 2011.04; 117 (17): 4501-4510. ( PubMed, DOI )

Tatsukuni Ohno, Keisuke Oboki, Hideaki Morita, Naoki Kajiwara, Ken Arae, Shizuko Tanaka, Masako Ikeda, Motoyasu Iikura, Taishin Akiyama, Jun-ichiro Inoue, Kenji Matsumoto, Katsuko Sudo, Miyuki Azuma, Ko Okumura, Thomas Kamradt, Hirohisa Saito, Susumu Nakae. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation. PLoS ONE. 2011; 6 (4): e18404. ( PubMed, DOI )

Cao Y, Zhang L, Kamimura Y, Ritprajak P, Hashiguchi M, Hirose S, Azuma M. B7-H1 overexpression regulates epithelial -mesenchymal transition and accelerates carcinogenesis in skin. Cancer Res. 2010.12; ( PubMed, DOI )

Junko Hori, Hiroko Taniguchi, Mingcong Wang, Masamichi Oshima, Miyuki Azuma. GITR ligand-mediated local expansion of regulatory T cells and immune privilege of corneal allografts. Invest. Ophthalmol. Vis. Sci.. 2010.12; 51 (12): 6556-6565. ( PubMed, DOI )

Yamaura K, Watanabe T, Boenisch O, Yeung M, Yang S, Magee CN, Padera R, Datta S, Schatton T, Kamimura Y, Azuma M, Najafian N. In vivo function of immune inhibitory molecule b7-h4 in alloimmune responses. Am J Transplant. 2010.10; 10 (10): 2355-2362. ( PubMed, DOI )

Qing Zhou, Meghan E Munger, Steven L Highfill, Jakub Tolar, Brenda J Weigel, Megan Riddle, Arlene H Sharpe, Daniel A Vallera, Miyuki Azuma, Bruce L Levine, Carl H June, William J Murphy, David H Munn, Bruce R Blazar. Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood. 2010.10; 116 (14): 2484-2493. ( PubMed, DOI )

Tomohiro Fukaya, Hideaki Takagi, Yumiko Sato, Kaori Sato, Kawori Eizumi, Honami Taya, Tahiro Shin, Lieping Chen, Chen Dong, Miyuki Azuma, Hideo Yagita, Bernard Malissen, Katsuaki Sato. Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance. Blood. 2010.09; 116 (13): 2266-2276. ( PubMed, DOI )

Oliver T Burton, Paola Zaccone, Jenny M Phillips, Hugo De La Peña, Zoltán Fehérvári, Miyuki Azuma, Sarah Gibbs, Brigitta Stockinger, Anne Cooke. Roles for TGF-beta and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice. J. Immunol.. 2010.09; 185 (5): 2754-2762. ( PubMed, DOI )

Peter Dias, Francesca Giannoni, Lian Ni Lee, Dongun Han, Sorah Yoon, Hideo Yagita, Miyuki Azuma, Sally R Sarawar. CD4 T-cell help programs a change in CD8 T-cell function enabling effective long-term control of murine gammaherpesvirus 68: role of PD-1-PD-L1 interactions. J. Virol.. 2010.08; 84 (16): 8241-8249. ( PubMed, DOI )

Kobori H, Hashiguchi M, Piao J, Kato M, Ritprajak P, Azuma M. Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites. Immunology. 2010.07; 130 (3): 363-373. ( PubMed, DOI )

Ritprajak P, Hashiguchi M, Tsushima F, Chalermsarp N, Azuma M. Keratinocyte-associated B7-H1 directly regulates cutaneous effector CD8+ T cell responses. J Immunol. 2010.05; 184 (9): 4918-4925. ( PubMed, DOI )

M Morita, M Fujino, G Jiang, Y Kitazawa, L Xie, M Azuma, H Yagita, S Nagao, A Sugioka, Y Kurosawa, S Takahara, J Fung, S Qian, L Lu, X-K Li. PD-1/B7-H1 interaction contribute to the spontaneous acceptance of mouse liver allograft. Am. J. Transplant.. 2010.01; 10 (1): 40-46. ( PubMed, DOI )

Azuma M, Ritprajak P, Hashiguchi M. Topical application of siRNA targeting cutaneous dendritic cells in allergic skin disease. Methods Mol Biol. 2010; 623 373-381. ( PubMed, DOI )

Miyuki Azuma. Role of the glucocorticoid-induced TNFR-related protein (GITR)-GITR ligand pathway in innate and adaptive immunity. Crit. Rev. Immunol.. 2010; 30 (6): 547-557. ( PubMed )

Kamimura Y, Kobori H, Piao J, Hashiguchi M, Matsumoto K, Hirose S, Azuma M. Possible involvement of soluble B7-H4 in T cell-mediated inflammatory immune responses. Biochem Biophys Res Commun. 2009.11; 389 (2): 349-353. ( PubMed, DOI )

Brian T Fife, Kristen E Pauken, Todd N Eagar, Takashi Obu, Jenny Wu, Qizhi Tang, Miyuki Azuma, Matthew F Krummel, Jeffrey A Bluestone. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat. Immunol.. 2009.11; 10 (11): 1185-1192. ( PubMed, DOI )

Keisuke Okudaira, Ryota Hokari, Yoshikazu Tsuzuki, Yoshikiyo Okada, Shunsuke Komoto, Chikako Watanabe, Chie Kurihara, Atsushi Kawaguchi, Shigeaki Nagao, Miyuki Azuma, Hideo Yagita, Soichiro Miura. Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model. Int. J. Oncol.. 2009.10; 35 (4): 741-749. ( PubMed )

Pornpan Youngnak-Piboonratanakit, Kittipong Dhanuthai, Kobkan Thongprasom, Pimporn Luckprom, Wilairat Sarideechaigul, Lakana Luangjarmekorn, Miyuki Azuma. Expression of IFN-gamma before and after treatment of oral lichen planus with 0.1% fluocinolone acetonide in orabase. J. Oral Pathol. Med.. 2009.10; 38 (9): 689-694. ( PubMed, DOI )

Piao J, Kamimura Y, Iwai H, Cao Y, Kikuchi K, Hashiguchi M, Masunaga T, Jiang H, Tamura K, Sakaguchi S, Azuma M. Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours. Immunology. 2009.08; 127 (4): 489-499. ( PubMed, DOI )

Chalermsarp N, Azuma M. Identification of three distinct subsets of migrating dendritic cells from oral mucosa within the regional lymph nodes. Immunology. 2009.08; 127 (4): 558-566. ( PubMed, DOI )

Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, Azuma M, Lee SK, Mizutani S, Morio T. Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol. 2009.05; 182 (9): 5515-5527. ( PubMed, DOI )

Masafumi Nakayama, Hisaya Akiba, Kazuyoshi Takeda, Yuko Kojima, Masaaki Hashiguchi, Miyuki Azuma, Hideo Yagita, Ko Okumura. Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation. Blood. 2009.04; 113 (16): 3821-3830. ( PubMed, DOI )

Kamimura Y, Iwai H, Piao J, Hashiguchi M, Azuma M. The glucocorticoid-induced TNF receptor-related protein (GITR)-GITR ligand pathway acts as a mediator of cutaneous dendritic cell migration and promotes T cell-mediated acquired immunity. J Immunol. 2009.03; 182 (5): 2708-2716. ( PubMed, DOI )

Vrajesh V Parekh, Saif Lalani, Sungjune Kim, Ramesh Halder, Miyuki Azuma, Hideo Yagita, Vipin Kumar, Lan Wu, Luc Van Kaer. PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J. Immunol.. 2009.03; 182 (5): 2816-2826. ( PubMed, DOI )

Deepak Yadav, Natasha Hill, Hideo Yagita, Miyuki Azuma, Nora Sarvetnick. Altered availability of PD-1/PD ligands is associated with the failure to control autoimmunity in NOD mice. Cell. Immunol.. 2009; 258 (2): 161-171. ( PubMed, DOI )

M Okano, N Otsuki, M Azuma, T Fujiwara, S Kariya, Y Sugata, T Higaki, K Kino, Y Tanimoto, K Okubo, K Nishizaki. Allergen-specific immunotherapy alters the expression of B and T lymphocyte attenuator, a co-inhibitory molecule, in allergic rhinitis. Clin. Exp. Allergy. 2008.12; 38 (12): 1891-1900. ( PubMed, DOI )

Woo-Sung Chang, Ji-Yeon Kim, Yeon-Jeong Kim, Yun-Sun Kim, Jung-Mi Lee, Miyuki Azuma, Hideo Yagita, Chang-Yuil Kang. Cutting edge: Programmed death-1/programmed death ligand 1 interaction regulates the induction and maintenance of invariant NKT cell anergy. J. Immunol.. 2008.11; 181 (10): 6707-6710. ( PubMed )

Hashiguchi M, Kobori H, Ritprajak P, Kamimura Y, Kozono H, Azuma M. Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. Proc Natl Acad Sci U S A. 2008.07; 105 (30): 10495-10500. ( PubMed, DOI )

Ritprajak P, Hashiguchi M, Azuma M. Topical application of cream-emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cells. Mol Ther. 2008.07; 16 (7): 1323-1330. ( PubMed, DOI )

Igarashi H, Cao Y, Iwai H, Piao J, Kamimura Y, Hashiguchi M, Amagasa T, Azuma M. GITR ligand-costimulation activates effector and regulatory functions of CD4+ T cells. Biochem Biophys Res Commun. 2008.05; 369 (4): 1134-1138. ( PubMed, DOI )

Jun Yang, Joyce Popoola, Shakila Khandwala, Nidyanandh Vadivel, Vijay Vanguri, Xueli Yuan, Shirine Dada, Indira Guleria, Chaorui Tian, M Javeed Ansari, Tahiro Shin, Hideo Yagita, Miyuki Azuma, Mohamed H Sayegh, Anil Chandraker. Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy. Circulation. 2008.02; 117 (5): 660-669. ( PubMed, DOI )

Koichiro Matsumoto, Satoru Fukuyama, Miyuki Eguchi-Tsuda, Takako Nakano, Takafumi Matsumoto, Mikiko Matsumura, Atsushi Moriwaki, Keiko Kan-o, Yoshihiro Wada, Hideo Yagita, Tahiro Shin, Drew M Pardoll, Rirprajak Patcharee, Miyuki Azuma, Yoichi Nakanishi, Hiromasa Inoue. B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma. Biochem. Biophys. Res. Commun.. 2008.01; 365 (1): 170-175. ( PubMed, DOI )

Antje Habicht, Shirine Dada, Mollie Jurewicz, Brian T Fife, Hideo Yagita, Miyuki Azuma, Mohamed H Sayegh, Indira Guleria. A link between PDL1 and T regulatory cells in fetomaternal tolerance. J. Immunol.. 2007.10; 179 (8): 5211-5219. ( PubMed )

Katsunori Tanaka, Monica J Albin, Xueli Yuan, Kazuhiro Yamaura, Antje Habicht, Takaya Murayama, Martin Grimm, Ana Maria Waaga, Takuya Ueno, Robert F Padera, Hideo Yagita, Miyuki Azuma, Tahiro Shin, Bruce R Blazar, David M Rothstein, Mohamed H Sayegh, Nader Najafian. PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection. J. Immunol.. 2007.10; 179 (8): 5204-5210. ( PubMed )

Indira Guleria, Melanie Gubbels Bupp, Shirine Dada, Brian Fife, Qizhi Tang, Mohammed Javeed Ansari, Subbulaxmi Trikudanathan, Nidyanandh Vadivel, Paolo Fiorina, Hideo Yagita, Miyuki Azuma, Mark Atkinson, Jeffrey A Bluestone, Mohamed H Sayegh. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin. Immunol.. 2007.10; 125 (1): 16-25. ( PubMed, DOI )

Madhav D Sharma, Babak Baban, Phillip Chandler, De-Yan Hou, Nagendra Singh, Hideo Yagita, Miyuki Azuma, Bruce R Blazar, Andrew L Mellor, David H Munn. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J. Clin. Invest.. 2007.09; 117 (9): 2570-2582. ( PubMed, DOI )

Akira Kawano, Shinji Shimoda, Takashi Kamihira, Fumihiko Ishikawa, Hiroaki Niiro, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara, Minoru Nakamura, Atsumasa Komori, Kiyoshi Migita, Hiromi Ishibashi, Miyuki Azuma, M Eric Gershwin, Mine Harada. Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis. J. Immunol.. 2007.09; 179 (5): 3315-3324. ( PubMed )

Juro Nakanishi, Yoshihiro Wada, Koichiro Matsumoto, Miyuki Azuma, Ken Kikuchi, Shoichi Ueda. Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers. Cancer Immunol. Immunother.. 2007.08; 56 (8): 1173-1182. ( PubMed, DOI )

Tsunekazu Oikawa, Hiroki Takahashi, Tomohisa Ishikawa, Atsushi Hokari, Noriko Otsuki, Miyuki Azuma, Mikio Zeniya, Hisao Tajiri. Intrahepatic expression of the co-stimulatory molecules programmed death-1, and its ligands in autoimmune liver disease. Pathol. Int.. 2007.08; 57 (8): 485-492. ( PubMed, DOI )

Tanaka K, Jinhua P, Omura K, Azuma M. Multipotency of CD11bhighGr-1+ immature myeloid cells accumulating in oral squamous cell carcinoma-bearing mice. Oral Oncol. 2007.07; 43 (6): 586-592. ( PubMed, DOI )

Yoshinori Seko, Hideo Yagita, Ko Okumura, Miyuki Azuma, Ryozo Nagai. Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3. Cardiovasc. Res.. 2007.07; 75 (1): 158-167. ( PubMed, DOI )

Yadav, D.Fine, C.Azuma, M.Sarvetnick, N.. B7-1 mediated costimulation regulates pancreatic autoimmunity Mol Immunol. 2007.04; 44 (10): 2616-2624.

Nomi, T.Sho, M.Akahori, T.Hamada, K.Kubo, A.Kanehiro, H.Nakamura, S.Enomoto, K.Yagita, H.Azuma, M.Nakajima, Y.. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer Clin Cancer Res. 2007.04; 13 (7): 2151-2157.

Kitazawa, Y.Fujino, M.Wang, Q.Kimura, H.Azuma, M.Kubo, M.Abe, R.Li, X. K.. Involvement of the programmed death-1/programmed death-1 ligand pathway in CD4+CD25+ regulatory T-cell activity to suppress alloimmune responses Transplantation. 2007.03; 83 (6): 774-782.

Hori, J.Wang, M.Miyashita, M.Tanemoto, K.Takahashi, H.Takemori, T.Okumura, K.Yagita, H.Azuma, M.. B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts J Immunol. 2006.11; 177 (9): 5928-5935.

Fife, B. T.Guleria, I.Gubbels Bupp, M.Eagar, T. N.Tang, Q.Bour-Jordan, H.Yagita, H.Azuma, M.Sayegh, M. H.Bluestone, J. A.. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway J Exp Med. 2006.11; 203 (12): 2737-2747.

Azuma M. Fundamental mechanisms of host immune responses to infection. J Periodontal Res. 2006.10; 41 (5): 361-373. ( PubMed, DOI )

Oikawa T, Kamimura Y, Akiba H, Yagita H, Okumura K, Takahashi H, Zeniya M, Tajiri H, Azuma M. Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease. J Immunol. 2006.10; 177 (7): 4281-4287. ( PubMed )

Zhang J, Kawashima N, Suda H, Nakano Y, Takano Y, Azuma M. The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties. Int Immunol. 2006.09; 18 (9): 1375-1384. ( PubMed, DOI )

Fukushima, A.Yamaguchi, T.Azuma, M.Yagita, H.Ueno, H.. Involvement of programmed death-ligand 2 (PD-L2) in the development of experimental allergic conjunctivitis in mice Br J Ophthalmol. 2006.08; 90 (8): 1040-1045.

Otsuki N, Kamimura Y, Hashiguchi M, Azuma M. Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells. Biochem Biophys Res Commun. 2006.06; 344 (4): 1121-1127. ( PubMed, DOI )

Youngnak-Piboonratanakit P, Tsushima F, Otsuki N, Igarashi H, Omura K, Azuma M. Expression and regulation of human CD275 on endothelial cells in healthy and inflamed mucosal tissues. Scand J Immunol. 2006.03; 63 (3): 191-198. ( PubMed, DOI )

Tsushima F, Tanaka K, Otsuki N, Youngnak P, Iwai H, Omura K, Azuma M. Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma. Oral Oncol. 2006.03; 42 (3): 268-274. ( PubMed, DOI )

Zhu, B.Guleria, I.Khosroshahi, A.Chitnis, T.Imitola, J.Azuma, M.Yagita, H.Sayegh, M. H.Khoury, S. J.. Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis J Immunol. 2006.03; 176 (6): 3480-3489.

Yamazaki, T.Akiba, H.Koyanagi, A.Azuma, M.Yagita, H.Okumura, K.. Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production J Immunol. 2005.08; 175 (3): 1586-1592.

Guleria, I.Khosroshahi, A.Ansari, M. J.Habicht, A.Azuma, M.Yagita, H.Noelle, R. J.Coyle, A.Mellor, A. L.Khoury, S. J.Sayegh, M. H.. A critical role for the programmed death ligand 1 in fetomaternal tolerance J Exp Med. 2005.07; 202 (2): 231-237.

Ito, T.Ueno, T.Clarkson, M. R.Yuan, X.Jurewicz, M. M.Yagita, H.Azuma, M.Sharpe, A. H.Auchincloss, H., Jr.Sayegh, M. H.Najafian, N.. Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo J Immunol. 2005.06; 174 (11): 6648-6656.

Sandner, S. E.Clarkson, M. R.Salama, A. D.Sanchez-Fueyo, A.Domenig, C.Habicht, A.Najafian, N.Yagita, H.Azuma, M.Turka, L. A.Sayegh, M. H.. Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo J Immunol. 2005.05; 174 (6): 3408-3415.

Tsuda, M.Matsumoto, K.Inoue, H.Matsumura, M.Nakano, T.Mori, A.Azuma, M.Nakanishi, Y.. Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA Biochem Biophys Res Commun. 2005.04; 330 (1): 263-270.

Ohigashi, Y.Sho, M.Yamada, Y.Tsurui, Y.Hamada, K.Ikeda, N.Mizuno, T.Yoriki, R.Kashizuka, H.Yane, K.Tsushima, F.Otsuki, N.Yagita, H.Azuma, M.Nakajima, Y.. Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer Clin Cancer Res. 2005.04; 11 (8): 2947-2953.

Kojima T, Aoki K, Nonaka K, Saito H, Azuma M, Iwai H, Varghese BJ, Yoshimasu H, Baron R, Ohya K, Amagasa T. Subcutaneous injections of a TNF-alpha antagonistic peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis. J Med Dent Sci. 2005.03; 52 (1): 91-99. ( PubMed )

張　　健、東　みゆき. 歯髄における免疫応答メカニズムを考えるために　樹状細胞は何をしているのか？ The Quintessence. 2005; 24 1375-1382.

神村　洋介、東　みゆき. 新しいB7ファミリー分子の機能 炎症と免疫. 2005; 13 676-682.

Nagahama K, Aoki K, Nonaka K, Saito H, Takahashi M, Varghese BJ, Shimokawa H, Azuma M, Ohya K, Ohyama K. The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis. Bone. 2004.11; 35 (5): 1059-1068. ( PubMed, DOI )

Koga N, Suzuki J, Kosuge H, Haraguchi G, Onai Y, Futamatsu H, Maejima Y, Gotoh R, Saiki H, Tsushima F, Azuma M, Isobe M. Blockade of the interaction between PD-1 and PD-L1 accelerates graft arterial disease in cardiac allografts. Arterioscler Thromb Vasc Biol. 2004.11; 24 (11): 2057-2062. ( PubMed, DOI )

Tani, K.Azuma, M.Nakazaki, Y.Oyaizu, N.Hase, H.Ohata, J.Takahashi, K.OiwaMonna, M.Hanazawa, K.Wakumoto, Y.Kawai, K.Noguchi, M.Soda, Y.Kunisaki, R.Watari, K.Takahashi, S.Machida, U.Satoh, N.Tojo, A.Maekawa, T.Eriguchi, M.Tomikawa, S.Tahara, H.Inoue, Y.Yoshikawa, H.Yamada, Y.Iwamoto, A.Hamada,Yamashita, N.Okumura, K.Kakizoe, T.Akaza, H.Fujime, M.Clift, S.Ando, D.Mulligan, R.Asano, S.. Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: clinical and immunological findings Mol Ther. 2004.10; 10 (4): 799-816.

Zhou X, Kubo M, Nishitsuji H, Kurihara K, Ikeda T, Ohashi T, Azuma M, Masuda T, Kannagi M. Inducible-costimulator-mediated suppression of human immunodeficiency virus type 1 replication in CD4(+) T lymphocytes. Virology. 2004.08; 325 (2): 252-263. ( PubMed, DOI )

Oei, E.Kalb, T.Beuria, P.Allez, M.Nakazawa, A.Azuma, M.Timony, M.Stuart, Z.Chen, H.Sperber, K.. Accessory cell function of airway epithelial cells Am J Physiol Lung Cell Mol Physiol. 2004.08; 287 (2): 318-331.

Konishi, J.Yamazaki, K.Azuma, M.Kinoshita, I.Dosaka-Akita, H.Nishimura, M.. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression Clin Cancer Res. 2004.08; 10 (15): 5094-5100.

Youngnak-Piboonratanakit P, Tsushima F, Otsuki N, Igarashi H, Machida U, Iwai H, Takahashi Y, Omura K, Yokozeki H, Azuma M. The expression of B7-H1 on keratinocytes in chronic inflammatory mucocutaneous disease and its regulatory role. Immunol Lett. 2004.07; 94 (3): 215-222. ( PubMed, DOI )

Kanamaru F, Iwai H, Ikeda T, Nakajima A, Ishikawa I, Azuma M. Expression of membrane-bound and soluble receptor activator of NF-kappaB ligand (RANKL) in human T cells. Immunol Lett. 2004.07; 94 (3): 239-246. ( PubMed, DOI )

Kanamaru F, Youngnak P, Hashiguchi M, Nishioka T, Takahashi T, Sakaguchi S, Ishikawa I, Azuma M. Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J Immunol. 2004.06; 172 (12): 7306-7314. ( PubMed )

Nakazawa, A.Dotan, I.Brimnes, J.Allez, M.Shao, L.Tsushima, F.Azuma, M.Mayer, L.. The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells Gastroenterology. 2004.05; 126 (5): 1347-1357.

Hase, H.Kanno, Y.Kojima, M.Hasegawa, K.Sakurai, D.Kojima, H.Tsuchiya, N.Tokunaga, K.Masawa, N.Azuma, M.Okumura, K.Kobata, T.. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex Blood. 2004.03; 103 (6): 2257-2265.

Koichiro Matsumoto, Hiromasa Inoue, Takako Nakano, Miyuki Tsuda, Yuki Yoshiura, Satoru Fukuyama, Fumihiko Tsushima, Tomoaki Hoshino, Hisamichi Aizawa, Hisaya Akiba, Drew Pardoll, Nobuyuki Hara, Hideo Yagita, Miyuki Azuma, Yoichi Nakanishi. B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism. J. Immunol.. 2004.02; 172 (4): 2530-2541. ( PubMed )

Aramaki, O.Shirasugi, N.Takayama, T.Shimazu, M.Kitajima, M.Ikeda, Y.Azuma, M.Okumura, K.Yagita, H.Niimi, M.. Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen Transplantation. 2004.01; 77 (1): 6-12.

Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol. 2003.10; 171 (8): 4156-4163. ( PubMed )

Tsushima F, Iwai H, Otsuki N, Abe M, Hirose S, Yamazaki T, Akiba H, Yagita H, Takahashi Y, Omura K, Okumura K, Azuma M. Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. Eur J Immunol. 2003.10; 33 (10): 2773-2782. ( PubMed, DOI )

Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol. 2003.09; 171 (6): 2848-2854. ( PubMed )

Youngnak P, Kozono Y, Kozono H, Iwai H, Otsuki N, Jin H, Omura K, Yagita H, Pardoll DM, Chen L, Azuma M. Differential binding properties of B7-H1 and B7-DC to programmed death-1. Biochem Biophys Res Commun. 2003.08; 307 (3): 672-677. ( PubMed )

Shin, T.Kennedy, G.Gorski, K.Tsuchiya, H.Koseki, H.Azuma, M.Yagita, H.Chen, L.Powell, J.Pardoll, D.Housseau, F.. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor J Exp Med. 2003.07; 198 (1): 31-38.

Ansari, M. J.Salama, A. D.Chitnis, T.Smith, R. N.Yagita, H.Akiba, H.Yamazaki, T.Azuma, M.Iwai, H.Khoury, S. J.Auchincloss, H., Jr.Sayegh, M. H.. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice J Exp Med. 2003.07; 198 (1): 63-69.

Salama, A. D.Chitnis, T.Imitola, J.Ansari, M. J.Akiba, H.Tushima, F.Azuma, M.Yagita, H.Sayegh, M. H.Khoury, S. J.. Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis J Exp Med. 2003.07; 198 (1): 71-78.

Totsuka T, Kanai T, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, Watanabe M. Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology. 2003.02; 124 (2): 410-421. ( PubMed, DOI )

Pornpan younnak,田中　香衣、高橋　雄三、小林　健、東　みゆき. 口腔扁平苔癬における抑制補助シグナル分子PD-1とそのリガンド分子発現 口腔病学会雑誌. 2003; 70 196.

津島　文彦、神村　洋介、東　みゆき. 補助シグナル操作による癌免疫治療 Biotherapy. 2003; 14 (6): 566-572.

Yamazaki, T.Akiba, H.Iwai, H.Matsuda, H.Aoki, M.Tanno, Y.Shin, T.Tsuchiya, H.Pardoll, D. M.Okumura, K.Azuma, M.Yagita, H.. Expression of programmed death 1 ligands by murine T cells and APC J Immunol. 2002.11; 169 (10): 5538-5545.

Iwai H, Kozono Y, Hirose S, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M. Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation. J Immunol. 2002.10; 169 (8): 4332-4339. ( PubMed )

Ohata, J.Sakurai, J.Saito, K.Tani, K.Asano, S.Azuma, M.. Differential graft-versus-leukaemia effect by CD28 and CD40 co-stimulatory blockade after graft-versus-host disease prophylaxis Clin Exp Immunol. 2002.07; 129 (1): 61-68.

Seko, Y.Ishiyama, S.Nishikawa, T.Kasajima, T.Hiroe, M.Suzuki, S.Ishiwata, S.Kawai, S.Tanaka, Y.Azuma, M.Kobata, T.Yagita, H.Okumura, K.Nagai, R.. Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy Cardiovasc Pathol. 2002.05; 11 (3): 166-170.

Mogi, S.Ebata, T.Toda,H.Hirano,Y.Enomoto, S.Azuma, M.. The effect of recombinant CD80-Adenovirus and interleukin-12 on generation of cytotoxic T lymphocytes against autologous tumour in patients with oral squamous cell carcinoma Asian J Oral Maxillofac Surg. 2002; 14 87-94.

Seko, Y.Takahashi, N.Oshima, H.Shimozato, O.Akiba, H.Takeda, K.Kobata, T.Yagita, H.Okumura, K.Azuma, M.Nagai, R.. Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3 J Pathol. 2001.12; 195 (5): 593-603.

Nozawa, K.Ohata, J.Sakurai, J.Hashimoto, H.Miyajima, H.Yagita, H.Okumura, K.Azuma, M.. Preferential blockade of CD8(+) T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases J Immunol. 2001.11; 167 (9): 4981-4986.

Okano, M.Azuma, M.Yoshino, T.Hattori, H.Nakada, M.Satoskar, A. R.Harn, D. A., Jr.Nakayama, E.Akagi, T.Nishizaki, K.. Differential role of CD80 and CD86 molecules in the induction and the effector phases of allergic rhinitis in mice Am J Respir Crit Care Med. 2001.10; 164 (8): 1501-1507.

Hattori, H.Okano, M.Yoshino, T.Akagi, T.Nakayama, E.Saito, C.Satoskar, A. R.Ogawa, T.Azuma, M.Nishizaki, K.. Expression of costimulatory CD80/CD86-CD28/CD152 molecules in nasal mucosa of patients with perennial allergic rhinitis Clin Exp Allergy. 2001.08; 31 (8): 1242-1249.

Iwakami, S. I.Setoguchi, Y.Saijo, Y.Azuma, M.Fukuchi, Y.. Replication-deficient adenovirus-mediated transfer of B7-1 (CD80) cDNA induces anti-tumour immunity in isolated human lung cancer Respirology. 2001.06; 6 (2): 135-144.

Guo, Z.Wu, T.Kirchhof, N.Mital, D.Williams, J. W.Azuma, M.Sutherland, D. E.Hering, B. J.. Immunotherapy with nondepleting anti-CD4 monoclonal antibodies but not CD28 antagonists protects islet graft in spontaneously diabetic nod mice from autoimmune destruction and allogeneic and xenogeneic graft rejection Transplantation. 2001.06; 71 (11): 1656-1665.

Nuriya, S.Enomoto, S.Azuma, M.. The role of CTLA-4 in murine contact hypersensitivity J Invest Dermatol. 2001.05; 116 (5): 764-768.

Ebata, T.Mogi, S.Hata, Y.Fujimoto, J. I.Yagita, H.Okumura, K.Azuma, M.. Rapid induction of CD95 ligand and CD4+ T cell-mediated apoptosis by CD137 (4-1BB) costimulation Eur J Immunol. 2001.05; 31 (5): 1410-1406.

Mogi, S.Sakurai, J.Kohsaka, T.Enomoto, S.Yagita, H.Okumura, K.Azuma, M.. Tumour rejection by gene transfer of 4-1BB ligand into a CD80(+) murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells Immunology. 2000.12; 101 (4): 541-547.

Azuma M. [T cell costimulation and diseases]. Kokubyo Gakkai Zasshi. 2000.09; 67 (3): 233-239. ( PubMed )

Saegusa, K.Ishimaru, N.Yanagi, K.Haneji, N.Nishino, M.Azuma, M.Saito, I.Hayashi, Y.. Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjogren's syndrome J Immunol. 2000.08; 165 (4): 2251-2257.

Yamamoto, M.Kiyono, H.Kweon, M. N.Yamamoto, S.Fujihashi, K.Kurazono, H.Imaoka, K.Bluethmann, H.Takahashi, I.Takeda, Y.Azuma, M.McGhee, J. R.. Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses J Infect Dis. 2000.07; 182 (1): 180-190.

Oki, S.Otsuki, N.Kohsaka, T.Azuma, M.. Stat6 activation and Th2 cell differentiation [correction of proliferation] driven by CD28 [correction of CD28 signals] Eur J Immunol. 2000.05; 30 (5): 1416-1424.

Saegusa, K.Ishimaru, N.Yanagi, K.Haneji, N.Nishino, M.Azuma, M.Saito, I.Hayashi, Y.. Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjogren's syndrome (SS) through up-regulated Th2 response Clin Exp Immunol. 2000.02; 119 (2): 354-360.

Kawamura, T.Azuma, M.Kayagaki, N.Shimada, S.Yagita, H.Okumura, K.. Fas/Fas ligand-mediated apoptosis of murine Langerhans cells J Dermatol Sci. 2000.02; 22 (2): 96-101.

Kobata, T.Azuma, M.Yagita, H.Okumura, K.. Role of costimulatory molecules in autoimmunity Rev Immunogenet. 2000.02; 2 (1): 74-80.

Sakurai, J.Ohata, J.Saito, K.Miyajima, H.Hirano, T.Kohsaka, T.Enomoto, S.Okumura, K.Azuma, M.. Blockade of CTLA-4 signals inhibits Th2-mediated murine chronic graft-versus-host disease by an enhanced expansion of regulatory CD8+ T cells J Immunol. 2000.01; 164 (2): 664-669.

Tani, K.Nakazaki, Y.Hase, H.Takahashi, K.Azuma, M.Ohata, J.Kitamura, R.Komine, F.Oiwa, M.Masunaga, A.Maekawa, T.Satoh, N.Adachi, D.Soda, Y.Machida, .Endo, M.Yamazaki, T.Watari, K.Tojo, A.Yamashita, N.Tomikawa, S.Eriguchi, M.Hamada, H.Wakumoto, Y.Hanazawa, K.Okumura, K.. Progress reports on immune gene therapy for stage IV renal cell cancer using lethally irradiated granulocyte-macrophage colony-stimulating factor-transduced autologous renal cancer cells Cancer Chemother Pharmacol. 2000; 46 Suppl 573-576.

東　みゆき、Yang Yue、張　晨陽、永井　重徳. 口腔粘膜の免疫寛容 臨床免疫・アレルギー科. 2022.01; 77 (1): 25-30.

池田　恵莉、竹内　康雄、東 みゆき.. 解析技術の進展とデータ駆動型・ターゲット機能型研究最前線：第3節　歯周病の口腔細菌叢 ヒトマイクロバイオーム. 2020.06; 2 433-442.

古澤慧美、東　みゆき. ランゲルハンス細胞のPD-L2分子機能 炎症と免疫. 2020.02; 28 (2): 21-25.

東　みゆき. 口腔の免疫制御メカニズム：免疫チェックポイント分子PD-L1. 東京都歯科医師会雑誌. 2019.08; 67 (8): 347-353.

永井 重徳，東 みゆき. B7ファミリーの次世代免疫チェックポイント分子. 生体の科学. 2019.06; 70 (3): 179-186.

古澤　慧美、東　みゆき. 口腔における免疫制御メカニズム 別冊　Bio Clinica. 2018.10; 7 (3): 10-14.

東　みゆき. 免疫チェックポイント阻害薬　基礎から臨床まで ファルマシア. 2017.12; 53 (1): 25-29. ( DOI )

古澤　慧美、 Hirunwidchayarat W、 康　思ウェン、東　みゆき. 口腔粘膜における特有の免疫制御機構 臨床免疫・アレルギー科. 2017.11; 68 (6): 656-661.

大野　建州、張　晨陽、東　みゆき. 舌下免疫療法の抑制効果発現における舌下粘膜樹状細胞の関与 臨床免疫・アレルギー科. 2016; 65 297-303.

東　みゆき. 上皮バリアと炎症 炎症と免疫. 2014; 22

東　みゆき. 補助シグナル分子 南山堂医学大辞典　第 19版. 2014; 第19版

東　みゆき. -自己免疫疾患の基礎-抑制補助シグナルン分子と自己免疫 最新医学. 2005; 60 1333-1344.

東　みゆき. 免疫寛容と自己免疫：抑制補助シグナル分子と制御性T細胞による自己免疫制御 細胞. 2005; 38 3-6.

東　みゆき. 共刺激分子による免疫抑制-その新しい展開- 耳鼻免疫アレルギー. 2005; 23 (3): 1-5.

神村　洋介、東　みゆき. 癌免疫治療と補助刺激分子 Annual review 免疫2004. 2004; 161-170.

田中　香衣、東　みゆき. 補助刺激分子を標的とした分子治療 医学のあゆみ. 2004; 208 355-361.

神村　洋介、東　みゆき. 新規B7ファミリー分子B7-H3 臨床免疫. 2004; 41 (5): 507-510.

橋口　昌章、東　みゆき. B7ファミリーと免疫応答の制御 臨床免疫. 2004; 42 (1): 85-89.

金丸　史子、東　みゆき. 歯科・硬組織領域における免疫生物学 炎症と免疫. 2004; 12 417-424.

岩井　秀之、東　みゆき. 関節炎発症・進展における共刺激分子の役割 臨床免疫. 2003; 40 (1): 66-71.

岩井　秀之、東　みゆき. 新規補助シグナル分子を標的とした抗体療法 最新医学. 2003; 58 (12): 2778-2785.

東　みゆき. 癌と補助シグナル Molecular Medicine. 2002; 39 1164-1171.

大畑　順子、東　みゆき. co-stimulation 分子細胞治療. 2001; 2 202-204.

津島　文彦、神村　洋介、東　みゆき. ICOS(inducible costimulator)とTh2. アレルギー科. 2001; 12 291-297.

岩井　秀之、東　みゆき. 第3のT細胞共刺激分子としてのICOS/AILIM 臨床免疫. 2001; 36 344-350.

東　みゆき. 破骨細胞分化と免疫細胞 口病誌. 2001; 68 221.

岡野　三博、東　みゆき. CD86/CD86　CD28/CTLA4分子とIgE産生 喘息. 2001; 14 93-97.

大畑　順子、東　みゆき. 免疫応答と共刺激（Costimulation) 血液フロンティア. 2001; 11 21-30.

Sunthamala N, Pientong C, Kongyingyoes B, Thierry F, Azuma M, Ekalaksananan T. 29th HPV16E2 protein modulates host gene transcription and promotes immunosuppressive status in tumor microenvironment. HPV 2014 2014.09.20 Seattle, USA

Zhang C, Ohno T, Kang S, Bhingare AC, Takai T, Azuma M. Repeated antigen painting and sublingual immunotherapy convert sublingual dendritic cell populations. 13th International Symposium on Dendritic cells 2014.09.14 Tours, France

Bhingare AC, Ohno T, Tomura M, Zhang C, Azuma M. Demonstration of dental pulp DC migration to regional Lymph nodes using photoconvertible fluorescent protein transduced mice. 13th International Symposium on Dendritic cells 2014.09.14 Tours, France

Ohno T, Kondo Y, Zhang C, Azuma M. T cell-dependent and –independent regulatory roles of a new inhibitory molecule VISTA. 13th International Symposium on Dendritic cells 2014.09.14 Tours, France

Kunishige T, Taniguchi H, Ohno T, Azuma M, Hori J. The V-domain Ig suppressor of T cell activation1(VISTA) plays an essential role in the acceptance of corneal allografts. International Society for Eye Research 2014 2014.07.20 USA

Amrita Widyagarini, Yohei Kawano, Chenyang Zhang, Miyuki Azuma. VSIG4/CRIg, a new B7 family ligand, directly regulates early CD8⁺ T cell activation through its counter-receptor in a narrow window. 第51回日本免疫学会 2022.12.07 熊本

Pissacha Daroonpan, Ryo Ouchi, Miyuki Azuma. Comprehensive analyses of immune profile in tumor-microenvironment of tongue squamous cell carcinoma. 第51回日本免疫学会 2022.12.07 熊本

Chenyang Zhang, Farzana Sultana, Shigenori Nagai, Miyuki Azuma. Elevated expression of a novel immune checkpoint molecule, ILDR2 in inflammatory brain. 第51回日本免疫学会 2022.12.07 熊本

Shigenori Nagai, Miyuki Azuma. Fox01 suppresses IL-27-induced Tr1 cell differentiation. 第51回日本免疫学会 2022.12.07 熊本

Farzana Sultana, Chenyang Zhang, Shigeru Okuhara, Sigenori Nagai, Miyuki Azuma. A novel immune checkpoint molecule, ILDR2 is upregulated in the inflammatory by brain. 第87回口腔病学会 2022.12.02 東京

Yuting Yin, Rie Sakakibara, Takayuki Honda, Takahiro Mitsumura, Susumu Kirimura, Kenichi Okubo, Miyuki Azuma, Yasunari Miyazaki. Potential utility of elucidation of tumor immune microenvironment in malignant pleural mesothelioma as prognostic marker of Nivolumab. 第63回日本肺癌学会学術集会 2022.12.01 福岡

Pissacha Droonpan, Naoto Nishii, Fumihiko Tsushima, Hiroyuki Harada, Miyuki Azuma . Comprehensive analyses between clinical outcome and immunopathological profiles in tongue SCC. 第81回日本癌学会 2022.09.29 横浜

Widyagarini Amrita,　張　晨陽、　東　みゆき. 新規B7ファミリー免疫チェックポイントリガンドVSIG4は、カウンターレセプターを介して早期のCD8^＋T細胞活性化を抑制する. 第64回歯科基礎医学会 2022.09.18

張　晨陽、奥原　滋、 永井　重徳、　東　みゆき. 新規免疫チェクポイント分子ILDR2の発現. 第64回歯科基礎医学会学術大会 2022.09.18 徳島

西　航、若松　英、松島　遼平、西川　哲史、竹原　朋宏、豊田　博子、古畑　昌枝、町山　裕亮、西嶋　仁、竹内　新、東　みゆき、鈴木　実、横須賀　忠. ヒトPD-1/PD-L1抗体のT細胞疲弊解除機能を評価する分子イメージングシステムの確立. 第26回日本がん免疫学会 2022.07.20 島根

青島 萌乃歌、清水 佳奈子、山崎　哲、藤井 眞一郎. type I NKT細胞におけるOX40の関与機構の検討. 第14回日本血液疾患免疫療法学会学術集会 2022.06.11 web開催

ダルンパン　ピサッチャー、　西井　直人、　加島　義久、　濱崎　美和子、　津島　文彦、　原田　浩之、　池田　通、　東　みゆき. 肉眼分類とがん浸潤様式から見た舌扁平上皮癌の免疫プロファイルの多様性. 第76回日本口腔科学会 2022.04.21 福岡（ハイブリット開催）

Shigenori Nagai, Ao Xiang, Miyuki Azuma. Polymorphonuclear Myeloid-Derived Cells contributing to the immune paralysis are generated in the early phase of sepsis through the PD-1/PD-L1 pathway. 第50回日本免疫学会 2021.12.08 奈良　(ハイブリット開催）

Yuto Nagatomo, Chenyang Zhang, Amrita Widyagarini, Miyuki Azuma. The induction of cell surface ILDR2 in murine SCC tumor cells regulates antitumor T-cell responses. 第50回日本免疫学会 2021.12.08 奈良　(ハイブリット開催）

Honoka Aoshima, Kanako Shimizu, Satoru Yamasaki, Miyuki Azuma, Shin-ichiro Fujii.. The role of OX40 signaling in type I NKT cells.. 第50回日本免疫学会 2021.12.08 奈良　(ハイブリット開催）

Daroonpan Pissacha, Naoto Nishii, Yoshihisa Kashima, Fumihiko Tsushima, Hiroyuki Harada, Tohru Ikeda, Miyuki Azuma. Immune profiling analyses of tongue squamous cell carcinoma by multiplex immunofluorescence. 第66回日本口腔外科学会 2021.11.12 千葉（ハイブリット開催）

東　みゆき. がん微小環境の免疫評価のトランスレーショナルリサーチ. 第66回日本口腔外科学会 2021.11.12 千葉 (ハイブリット開催）

長友　優斗、張　晨陽、東　みゆき. 新規免疫チェックポイント分子ILDR2の抗腫瘍免疫応答における影響. 第25回日本がん免疫学会 2021.07.01 和歌山

Daroonpan Pissacha, Naoto Nishii, Miyuki Azuma. Quantitation of multiple immune cell subsets in tongue squamous cell carcinoma by multiplexed immunofluorescence. 第25回日本がん免疫学会 2021.07.01 和歌山

東　みゆき. 口腔粘膜の免疫寛容機構. 第7回総合アレルギー講習会 2021.06.06 神戸（Web配信）

Pissacha　Droonpan、加島　義久、濱垣　美和子、西井　直人、津島　文彦、原田　浩之、池田　通、東　みゆき. マルチプレックス免疫組織染色による舌扁平上皮癌の免疫プロファイリング解析. 第75回日本口腔科学会 2021.05.12 大阪 (Web)

加島　義久、西井　直人、立浪　秀剛、永井　重徳、原田　浩之、東　みゆき. 境界部に限局したCD8⁺T細胞と制御性T細胞の浸潤を認める同所性マウス舌扁平上皮癌モデル. 第79回日本癌学会 2020.10.01 広島(Web・実地開催)

Wongtim Keeratika、永井　重徳、奥原　滋、東　みゆき. 免疫チェックポイント分子PD-L1の歯肉過剰発現は、早期および慢性の歯肉炎症を抑制する. 第62回歯科基礎医学会 2020.09.11 Web開催

Widyagarini Amrita、永井　重徳、東　みゆき. Binding and functional properties of VSIG4(V-set and Ig domain containing 4)-Ig fusion protein. 第62回歯科基礎医学会 2020.09.11 Web開催

永井　重徳、ヤン　ユエ、東　みゆき. 抗原反復塗布により舌下粘膜に現れるCD206陽性マクロファージの免疫寛容特性. 第62回歯科基礎医学会 2020.09.11 Web開催

Ao Xiang、東　みゆき、永井　重徳. ザイモザン誘導性免疫麻痺モデルにおけるPD-1/PD-L1経路の役割. 第62回歯科基礎医学会 2020.09.11 Web開催

Wongtim Keeratika、池田　恵莉、大野　建州、永井　重徳、奥原　滋、呉　圭哲、東　みゆき. 免疫チェックポイント分子PD-L1の歯肉過剰発現は、早期および慢性の歯肉炎症を抑制する. 第74回日本口腔科学会 2020.04.15 Web開催

Yang Yue, Nagai Shigenori, Azuma Miyuki. Identification of a unique macrophage subset induced by repeated antigen painting in sublingual mucosa to regulate T cell tolerance. 第48回日本免疫学会 2019.12.11 浜松

Furusawa Emi, Ohno Tatsukuni, Nagai Shigenori, Komiyama Takuya, Kobayashi Katsunori, Hamamoto Hidetoshi, Miyashin Michiyo, Yokozeki Hiroo, Azuma Miyuki. One of PD-1 ligand、PD-L2 induced on Langerhans cells augments cutaneous T cell-mediated immune responses. 第48回日本免疫学会 2019.12.11 浜松

古澤慧美、宮新美智世、東みゆき. 慢性口腔粘膜炎症におけるレジデントメモリーT細胞の性状と機能. 第84回　口腔病学会 2019.12.06 東京

Nagai S, Adiba-Nadya N, Tezuka H, Ohteki T, Matsuda S, Azuma M. P13K-Akt pathway enhances the differentiation of interleukin 27-induced type 1 regulatory T cell.. 17th IUIS 2019 (International Congress of Immunology) 2019.10.19 Beijing, China

Yang Y, Nagai S, Azuma M. Repeated antigen painting induces tolerogenic cells in sublingual mucosa. 17th IUIS 2019 (International Congress of Immunology) 2019.10.19 Beijing, China

Azuma M, Furusawa E, Nagai S, Yokozeki H. Silencing of PD-L2 by topical application of small interfering RNA inhibits elicitation of contact hypersensitivity. 17th IUIS2019 (International Congress of Immunology) 2019.10.19 Beijing, China

Azuma M, Tachinami H, Nishii N, Xia Y, Kashima Y, Nagai S, Li L, Tomihara K, Noguchi M. Differences of tumor-recruiting myeloid cells in murine squamous cell carcinoma influence the efficacy of immunotherapy combined with a TLR7 agonist and PD-L1 blockade. 17th IUIS2019(International Congress of Immunology) 2019.10.19 Beijing, China

東　みゆき. 研究を継続するということ. 第61回歯科基礎医学会 2019.10.12 東京

古澤慧美、宮新美智世、東みゆき. 表皮Langerhans細胞のPD-L2-発現制御は、接触性皮膚炎を抑制する. 第34回日本小児歯科学会　関東地方大会 2019.09.16 東京

Furusawa E, Ohno T, Nagai S, Noda T, Komiyama T, Kobayashi K, Hamamoto H, Miyashin M, Yokozeki H, Azuma M. Silencing of PD-L2/B7-DC by topical application of small interfering RNA inhibits elicitation of contact hypersensitivity. AAI 2019 (The American Association of Immunologists, Immunology) 2019.05.09 San Diego, USA

加島　義久、立浪　秀剛、原田　浩之、東　みゆき. マウス舌癌モデルの樹立と免疫組織学的解析. 第73回日本口腔科学会 2019.04.19 川越

立浪　秀剛、西井　直人、加島　義久、冨原　圭、野口　誠、東　みゆき. 腫瘍に集積するミエロイド系細胞の違いはPD-L1阻害剤との併用免疫療法効果に影響を与える. 第73回日本口腔科学会 2019.04.19 川越

Furusawa E, Noda T, Komiyama T, Ohno T, Yokozeki H, Kobayashi K, Hamamoto H, Miyashin M, Azuma M. Silencing effects of B7-DC in cutaneous DCs on allergic skin diseases. 第47回日本免疫学会 2018.12.10 福岡

Yang Y, Nagai S, Azuma M. Involvement of CD206⁺ cells in oral mucosal tolerance. 第47回日本免疫学会 2018.12.10 福岡

夏　玉龍、西井　直人、永井　重徳、東　みゆき、大野　建州. 抗腫瘍応答における内因性および腫瘍内投与IL-33の機能評価. 第77回日本癌学会 2018.09.27 大阪

Kumurus Murat、濱西　潤三、松村　謙臣、茶本　健司、三瀬　名丹、安彦郁、馬場　長、山口　建、村上　隆介、細江　裕子、東　みゆき、小西　郁夫、万代　昌紀. VISTA expressed in tumor cells regulates T cell function. 第77回日本癌学会 2018.09.27

立浪　秀剛、西井　直人、永井　重徳、加島　義久、冨原　圭、野口　誠、東　みゆき. 2つのマウス扁平上皮癌モデルの癌微小環境におけるミエロイド系細胞の相違とTLR7アゴニストの投与効果. 第77回日本癌学会 2018.09.27 大阪

Yang Yue、永井　重徳、東　みゆき. Immunosuppressive status of CD206hl cells appeared in sublingual mucosa. 第60回歯科基礎医学会 2018.09.05 福岡

立浪　秀剛、西井　直人、加島　義久、加藤　寛史、冨原　圭、野口　誠、東　みゆき. ２つのマウス扁平上皮癌モデルの癌微小環境におけるミエロイド系細胞の相違とTLR7アゴニストの投与効果. 第72回日本口腔科学会 2018.05.11 名古屋

Nagai S, Nadya N A, Tezuka H, Ohteki T, Matsuda S, Azuma M. PI3K-Akt pathway enhances type 1 regulatory T cell differentiation induced by IL-27. 第46回日本免疫学会 2017.12.12 仙台

Nishii N, Tachinami H, Kashima Y, Kondo Y, Harada H, Azuma M. Systemic administration of low dose TLR7 agonist augments antitumor responses in the PD-1 checkpoint blockade-resistant and regulatory T cell-dominant murine tumor models. 第46回日本免疫学会 2017.12.12 仙台

Hirunwidchayarat W, Furusawa E, Ohno T, Nagai S, Azuma M. Site-specific regulation of oral mucosa-recruiting CD8⁺T cells -Comparison of contact allergy between skin and oral mucosa-. 第46回日本免疫学会 2017.12.12 仙台

Furusawa E, Ohno T, Miyashin M, Azuma M. Silencing of B7-DC/PD-L2 in the cutaneous dendritic cells using siRNA inhibits contact allergy. 第46回日本免疫学会 2017.12.12 仙台

Nagai S, Nadya NA, Tezuka H, Ohteki T, Matsuda S, Azuma M. PI3K-Akt pathway enhances Tr1 differentoation induced by IL-27. ICIS 2017 2017.10.29 Kanazawa,Japan

西井　直人、立浪　秀剛、近藤　雄太、原田　浩之、東　みゆき. TLR7アゴニストは扁平上皮癌における制御性T細胞の集積を抑制し抗腫瘍効果を発揮する. 第62回日本口腔外科学会 2017.10.20 京都

Nadya Niken Adiba、東　みゆき、永井　重徳. PI3K-Akt経路はIL-27誘導Tr1細胞 分化を増強する. 第59回歯科基礎医学会 2017.09.16 塩尻

金　キン、永井　重徳、東　みゆき. 上皮系細胞におけるB7-H1発現に関わるシ グナル探索. 第59回歯科基礎医学会 2017.09.16 塩尻

Hirunwidcyayarat Worawalun、古澤　慧美、Kang Siwen、大野　建州、永井　重徳、 東　みゆき. 口腔接触アレルギーにおける粘膜局所でのCD8⁺T細胞の不活化. 第59回歯科基礎医学会 2017.09.16 塩尻

Hirunwidchayarat W, Ohno T, Tomura M, Azuma M. Site-specific regulation of CD8⁺ T cell activation in the oral mucosa. ICMI2017 2017.07.19 Washington DC, USA

Azuma M, Kang S, Hirunwidchayarat W, Ohno T. Unique PD-L1 expression in oral mucosae and trans-coinhibition by PD-L1-expressing keratinocytes in CD4⁺ T cell-mediated tissue inflammation. ICMI2017 2017.07.19 Washington DC, USA

東　みゆき. 今話題の免疫チェックポイントって何？. 第 34回アルペン口腔科学フォーラム 2017.07.02 富山

西井　直人、立浪　秀剛、近藤　雄太、原田　浩之、東　みゆき. PD-L1阻害 療法抵抗性の癌モデルにおける低濃度TLR7アゴニスト投与効果の検討. 第21 回日本がん免疫学会 2017.06.28 千葉

東　みゆき. 免疫チェックポイントの基礎. 第7回千駄木リウマチ膠原病セミナー　特別講演Ⅱ 2017.06.23 東京

東　みゆき. 口腔免疫と皮膚免疫システムの異同. 新潟大学皮膚科セミナー 2017.06.14 新潟

西井　直人、立浪　秀剛、近藤　雄太、冨原　圭、野口　誠、原田　浩之、 東　みゆき. 制御性T細胞集積が顕著な扁平上皮癌モデルでの低濃度TLRアゴニスト投与による癌縮小とチェックポイント阻害との併用効果. 第71回日本口腔科学会 2017.04.26 松山

東　みゆき. 扁平上皮癌に対するがん免疫応答と免疫療法. お茶の水SC クラブ第５回学術集会 2017.03.03 東京

Nishii Naoto, Tachinami Hidetake, Kondo Yuta, Harada Hiroyuki, Azuma Miyuki. Antitumor effects of a low dose systemic administration of a TLR7/8 agonist and its combined therapy with PD-L1 blockade. 第45回日本免疫学会 2016.12.05 宣野湾市、沖縄

Niken Adiba Nadaya, Azuma Miyuki, Nagai Shigenori. Regulation of IL-10 production from IL-27-induced Tr1 cells by PI3K-Akt pathway. 第45回日本免疫学会 2016.12.05 宣野湾市、沖縄

Hirunwidchayarat Worawalun, Ohno Tatsukuni, Kang Siwen, Nagai Sgigenori, Tomura Michio, Azuma Miyuki. Features of oral mucosal inflammation-comparative studies with skin inflammation- . 第45回日本免疫学会 2016.12.05 宣野湾市、沖縄

東　みゆき. 「口腔免疫システムと炎症制御」. 第 20回日本顎顔面インプラント学会 2016.12.03 東京都

Kang S, Zhang C, Ohno T, Azuma M. Unique B7-H1 expression on masticatory mucosae and trans-coinhibition by B7-H1-expressing keratinocytes in CD4⁺ T-cell-mediated mucosal inflammation. The 5th Tri-University Consortium on Oral Science and Education. 2016.10.27 Peking University, China

大沼　啓、大野　建州、東　みゆき. 抗マウス VISTA 抗体 MIH63の機能解析. 第23回日本歯科医学会総会 2016.10.23 福岡市

東　みゆき. 共刺激分子研究 —from bench to bedside and back to bench-. 第23回日本歯科医学会総会 2016.10.21 福岡市

西井　直人、立浪　秀剛、近藤　雄太、原田　浩之、東　みゆき. Antitumor effects of a low dose TLR7/8 agonist and its combined therapy with PD-L1 blockade. 第75回日本癌学会 2016.10.06 横浜市　

Hirunwidchayarat Worawalun、大野　建州、Kang Siwen、永井　重徳、東　みゆき. 口腔粘膜炎症において局所に集積するＴ細胞の解析. 第58回歯科基礎医学会 2016.08.24 札幌市

Nagai S, Kurebayashi Y, Baba Y, Minowa A, Azuma M, Yoshimura A, Koyasu S. Phosphorylation of Akt and Foxos induced by TGF-β negatively regulates the differentiation of induced regulatory T cells. ICI2016 2016.08.24 Melbourne, Australia

西井　直人、立浪　秀剛、近藤　雄太、原田　浩之、東　みゆき. 低濃度TLR7/8アゴニスト全身投与の抗腫瘍効果とPD-L1阻害との併用. 第58回歯科基礎医学会 2016.08.24 札幌市　

Niken Adiba Nadya、東　みゆき、永井　重徳. Tr1分化におけるP13の役割. 第58回歯科基礎医学会 2016.08.24 札幌市　

Ohno T, Kondo Y, Azuma M. VISTA/PD-1H negatively regulates generation of Th2-mediated allergic responses. ICI2016 2016.08.21 Melbourne, Australia

東　みゆき. がん治療が変わる –免疫チェックポイント阻害薬-. 免疫ふしぎ未来 2016 2016.08.07 東京

西井　直人、近藤　雄太、Lixin Li、 Walter Lau、原田　浩之、東　みゆき. Combined treatment with PD-L1 blockade and a TLR7/8 agonist dramatically enhances antitumor immunity. 第20回日本がん免疫学会 2016.07.27 大阪市　

Azuma M, Kang S, Ohno T, Zhang C. Unique sublingual dendritic cell state induces tolerance by sublingual immunotherapy. IADR2016 2016.06.22 Seoul, Korea

Kang S, Ohno T, Azuma M. Immune checkpoint molecule expressed on masticatory mucosae regulates tissue inflammation. IADR 2016 2016.06.22 Seoul, Korea

Kondo Y, Ohno T, Azuma M. Combined VISTA and CTLA-4 immune-checkpoint blockade enhances antitumor immunity. IADR 2016 2016.06.22 Seoul, Korea

東　みゆき. 共刺激分子を標的とする免疫制御 –その基礎から臨床まで-. 富山大学大学院セミナー 2016.05.23 富山

大野　建州、西井　直人、近藤　雄太、東　みゆき. 扁平上皮癌モデルにおける新規分子ＶＩＳＴＡを含めた免疫チェックポイント阻害効果の検討. 第70回口腔科学会 2016.04.16 福岡市

Nishii N, Kondo Y, Li L, Lau W, Harada H, Azuma M. Combined treatment with PD-L1 blockade and a TLR7/8 agonist dramatically enhances antitumor immunity. AACR2016 2016.04.16 New Orleans, USA

東　みゆき. 「口腔免疫と全身免疫システムとのリンク」. 第１回 Expert Meeting on PPP （掌蹠膿疱症研究会） 2016.01.30 東京

Ohno T,Kondo Y, Kang S, Azuma M. A novel inhibitory molecule VISTA regulates generation of Th2-mediated allergic responses. 第44回日本免疫学会 2015.11.18 札幌 Japan

Hirunwidchayarat W, Ohno T, Kang S, Nagai S,Tomura M, Azuma M. Recruiting T cells to the oral mucosa under the inflammatory condition. 第44回日本免疫学会 2015.11.18 札幌

Kang S, Ohno T, Nagai S, Azuma M. Masticatory mucosa-associated B7-H1 limits mucosal tissue damage. 第44回日本免疫学会 2015.11.18 札幌

Kondo Y,Ohno T, Bhingare AC, Yagita H, Harada K, Azuma M. Combinantional immune checkpoint blockade with VISTA and CTLA-4 enhances anti-tumor responses. 第44回日本免疫学会 2015.11.18 札幌

Nishii N, Bhingare A, Ohno T, Kondo Y, Azuma M. Endogenous and exogenous IL-33 promotes antitumor immunity. 第44回日本免疫学会 2015.11.18 札幌

Niken AN, Azuma M, Nagai S. Pole of PI3K in Tr1 cells differentiation. 第44回日本免疫学会 2015.11.18 札幌

Azuma M. Mechanisms of tolerance induction by sublingual immunotherapy. –focusing on sublingual mucosa dendritic cells-. International Symposium on Allergy and Inflammation 2015.10.29 Oh-arai, Ibaraki

近藤 雄太、大野 建州、ビンガレ　アルンダティ、八木田 秀雄、 原田 清、東 みゆき. VISTA とCTLA-4 コンビネーション阻害は、腫瘍浸潤 CD8+ T 細胞の多機能性を強化する. 第74回日本癌学会 2015.10.08 名古屋

西井 直人、ビンガレ　アルンダティ 、近藤 雄太、大野 建州、東　みゆき. 抗腫瘍免疫応答における内在性あるいは外来性 IL-33 の関与. 第74回日本癌学会 2015.10.08 名古屋

Hirunwidchayarat Worawalun, Ohno Tatsukuni, Kang Siwen, Nagai Shigenori, Azuma Miyuki. Analyses of oral mucosa recruiting T cells under the inflammatory condition. 第57回歯科基礎医学会 2015.09.11 新潟

康　思えん、大野 建州、永井 重徳、東 みゆき. 咀嚼粘膜に発現する B7-H1 は過度な免疫応答による損傷を保護している. 第57回歯科基礎医学会 2015.09.11 新潟

大野 建州、 康　思えん、 東 みゆき. 反復抗原塗布後における舌下粘膜樹状細胞の特徴. 第57回歯科基礎医学会 2015.09.11 新潟

Kang S, Ohno T, Nagai S, Azuma M. Selective regulation in expression of Co-inhibitory molecule B7-H1/PD-L1 masticatory mucosae. ICMI2015 2015.07.14 Berlin, Germany

Kondo Y, Ohno T, Bhingare AC, Yagita H, Harada K, Azuma M. Antitumor effects of VISTA blockade and its combination therapy with other immune checkpoint blockade. ICCIM 2015 2015.07.09 Tokyo,Japan

康 思えん、大野 建州、永井 重徳、東　みゆき. 咀嚼粘膜上皮における抑制共刺激分子 B7-H1（CD274）の選択的制御. 第69回日本口腔科学会 2015.05.13 大阪

近藤　雄太、大野　建州、ビンガレ　アルンダティ、原田　清、東　みゆき. マウス扁平上皮癌モデルにおける新規免疫チェックポイント分子VISTA阻害とPD-1/CTLA-4阻害との併用効果について. 第69回日本口腔科学会 2015.05.13 大阪

Kondo Y, Ohno T, Harada K, Azuma M. Effects of anti-VISTA mAb and its combination therapy in antitumor immunity. AAI 2015 2015.05.08 New Orleans,USA

Ohno T, Kondo Y, Azuma M. T cell-dependent and-independent regulatory roles of a new inhibitory molecule VISTA. AAI 2015 2015.05.08 New Orleans,USA

Azuma M, Zhang C, Kang S, Ohno T. Protective roles of PD-1:PD-1 pathway in a murine model of pollen allergy. Fundamental immunology and its therapeutic potential 2015 2015.04.14 New York. USA

Kang S, Zhang C, Ohno T, Azuma M. Constitutive expression of co-inhibitory molecule B7-H1(CD274)in masticatory mucosa. 第43回日本免疫学会 2014.12.12 京都

Worawalun H, Zhang C, OhnoT, Kang S, Takai T, AzumaM. Repeated antigen painting and sublingual immunotherapy convert sublingual dendritic cell subsets. 第43回日本免疫学会 2014.12.12 京都

Kondo Y, Ohno T, Zhang C, Yagita H, Harada K, Azuma M. Anti-tumor effects of mAb against a new immune-checkpoint molecule VISTA/PD-1H. 第43回日本免疫学会 2014.12.12 京都

Bhingare AC, Ohno T, Kondo Y, Zhang C, Azuma M. Involvement of host-derived IL-33 in antitumor responses. 第43回日本免疫学会 2014.12.12 京都

Zhang C, Kang S, Ohno T, Azuma M. PD-1 and/or B7-H1 deficiency in a japanese cedar pollinosis model. 第43回日本免疫学会 2014.12.10 京都

東　みゆき. 口腔免疫応答における制御機構. 歯科基礎医学会学術シンポジウム 2014.09.26 福岡

康　思えん、大野　建州、東　みゆき. 舌背および歯肉上皮の有棘細胞に恒常的に認められる免疫抑制B7-Ｈ1分子発現. 第56回歯科基礎医学会 2014.09.25 福岡

Sunthamala N, Pientong C, Ekalaksananan T, Bhingare A, Kondo Y, Ohno T, Azuma M. HPV16 E2 protein promotes innate immunity by modulating immunosuppressive status. 第73回日本癌学会 2014.09.25 横浜

近藤　雄太、大野　建州、張　晨陽、八木田　秀雄、原田　清、東　みゆき. Anti-tumor effects of mAb against a new immune-checkpoint molecule VISTA. 第73回日本癌学会 2014.09.25 横浜

東　みゆき. 免疫チェックポイント分子による免疫応答制御. 富山大学大学院セミナー 2014.08.14 富山

国重　智之,谷口　ヒロ子、大野　建州、東　みゆき、堀　純子. 角膜移植の免疫応答におけるV-domain Ig suppressor of T cell activation (VISTA)の役割. 第48回日本 眼炎症学会 2014.07.04 東京

康　思えん、張　晨陽、近藤　雄太、前川　祥吾、大野　建州、東　みゆき. 免疫抑制共刺激分子CD274の口腔粘膜上皮における異なる発現. 第68回口腔科学会 2014.05.07 東京

Bhingare AC、大野　建州、近藤　雄太、東　みゆき. 光変換蛍光タンパク発現マウスの利用による所属リンパ節に遊走する歯髄樹状細胞の同定. 第68回口腔科学会 2014.05.07 東京