Personnel Information

写真a

AZUMA Miyuki


Job title

Professor

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan

Laboratory Phone number

+81-3-5803-5935

Research Areas, Keywords

Immunology, Oral immunology, tumor immunology, immune regulation

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Dentistry, Dentistry, 1984.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Dental Research, Oral Surgery, Doctor's Course, 1988.03, Completed

Degree 【 display / non-display

  • DDS, PhD, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 1988.04
    -
    1990.02
    Tokyo Medical and Dental University, Faculty of Dentistry, Dental Resident
  • 1992.10
    -
    1993.03
    Tokyo Medical and Dental University, Faculty of Dentistry, Assistant Professor
  • 2000.04
    -
    2020.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Molecular Immunology, Professor
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University, Faculty of Dentistry, School of Dentistry, Director
  • 2020.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Molecular Immunology, Professor

External Career 【 display / non-display

  • 1990.03
    -
    1992.10
    Department of Immunology, DNAX Research Institute for Molecular and Cellular Biology, CA, USA, Postdoctral fellow
  • 1990.03
    -
    1992.09
    Becton Dickinson Immunocytometry Systems , Visiting Scientist
  • 1993.04
    -
    1996.03
    Juntendo University School of Medicine, , School of Medicine, Department of Immunology, Assistant professor
  • 1996.04
    -
    2000.03
    National Children's Medical Research Center , Department of Immunology, Staff Scientist

Academic Society Affiliations 【 display / non-display

  • Japanese Society for Immunology,

  • Japanese Stomatological Society

  • Japanese Cancer Association

  • American Association of Immunologists

  • The Stomatological Society,Japan

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Research Areas 【 display / non-display

  • Immunology

  • Pathobiological dentistry/Dental radiology

Qualification Acquired 【 display / non-display

  • Dentist

 

Published Papers & Misc 【 display / non-display

  • Yang Y, Nagai S, Kang S, Xia Y, Kawano Y, Miyake K, Karasuyama H, Azuma M. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting. International immunology. 2020.07; 32 (8): 509-518. ( PubMed, DOI )

  • Kashima Y, Nishii N, Tachinami H, Furusawa E, Nagai S, Harada H, Azuma M.. Orthotopic tongue squamous cell carcinoma (SCC) model exhibiting a different tumor-infiltrating T-cell status with margin-restricted CD8+ T cells and regulatory T cell-dominance, compared to skin SCC. Biochem. Biophys. Res. Commun.. 2020.05; 526 (1): 218-224. ( PubMed, DOI )

  • Rodriguez-Barbosa JI, Azuma M, Zelinskyy G, Perez-Simon JA, Del Rio ML. Critical role of PD-L1 expression on non-tumor cells rather than on tumor cells for effective anti-PD-L1 immunotherapy in a transplantable mouse hematopoietic tumor model. Cancer immunology, immunotherapy : CII. 2020.02; ( PubMed, DOI )

  • Kunishige T, Taniguchi H, Ohno T, Azuma M, Hori J. VISTA is crucial for corneal allograft survival and maintenance of immune privilege. Invest Ophthalmol Vis Sci. 2019.12; 60 (15): 4958-4965. ( PubMed, DOI )

  • Nagai S, Azuma M. The CD28-B7 family of co-signaling molecules. Adv Exp Med Biol.. 2019.11; 1189 25-51. ( PubMed, DOI )

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Books etc 【 display / non-display

  • Azuma M. Co-signal molecules in T cell activation:Immune regulation in health and disease. Springer, 2019.11 (ISBN : 978-981-32-9716-6)

  • Azuma M, Oki S. In: Kishimoto T., eds. Leukocyte Typing VI: White cell differentiation antigens. Garland Publishing Inc New York & London, 1997 CD28 workshop panel report

Conference Activities & Talks 【 display / non-display

  • Furusawa E, Ohno T, Miyashin M, Azuma M. Topical application of B7-DC/PD-L2 siRNA inhibits contact hypersensitivity. 15th International Symposium on Dendritic Cells 2018.06.10 Aachen,Germany

  • Nishii N, Tachinami H, Kondo Y, Xia Y, Kashima Y, Ohno T, Nagai S, Li L, Lau W, Harada H, Azuma M. Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy. 15th International Symposium on Dendritic Cells 2018.06.10 Aachen,Germany

  • Azuma M. Immune regulation in the oral cavity. Tokyo medical and Dental University-Taipei Medical University Joint Symposium 2016.11.12 Taiwan

  • Kang S, Ohno T, Azuma M. Prickle cells in the dorsal surface of tongue and gingiva spontaneously express an immunoregulatory molecule CD274 (B7-H1). The 56th Annual Meeting of Japanese Association for Oral Biology 2014.09.25 Fukuoka,Japan

  • 大野 建州、東 みゆき. 新規抑制性共刺激分子VISTAのT細胞依存的あるいは非依存的免疫応答における役割解析. 第56回歯科基礎医学会 2014.09.25 福岡

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Awards & Honors 【 display / non-display

  • Astra Award (Japanese Association of allergy),1998

  • Hajime Memorial Award (DNAX research institute),1992