Personnel Information


AZUMA Miyuki

Job title


Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan

Laboratory Phone number


Research Areas, Keywords

Immunology, Oral immunology, tumor immunology, immune regulation

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Dentistry, Dentistry, 1984.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Dental Research, Oral Surgery, Doctor's Course, 1988.03, Completed

Degree 【 display / non-display

  • DDS, PhD, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 1988.04
    Tokyo Medical and Dental University, Faculty of Dentistry, Dental Resident
  • 1992.10
    Tokyo Medical and Dental University, Faculty of Dentistry, Assistant Professor
  • 2000.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Molecular Immunology, Professor
  • 2019.04
    Tokyo Medical and Dental University, Faculty of Dentistry, School of Dentistry, Director
  • 2020.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Molecular Immunology, Professor

External Career 【 display / non-display

  • 1990.03
    Department of Immunology, DNAX Research Institute for Molecular and Cellular Biology, CA, USA, Postdoctral fellow
  • 1990.03
    Becton Dickinson Immunocytometry Systems , Visiting Scientist
  • 1993.04
    Juntendo University School of Medicine, , School of Medicine, Department of Immunology, Assistant professor
  • 1996.04
    National Children's Medical Research Center , Department of Immunology, Staff Scientist

Academic Society Affiliations 【 display / non-display

  • Japanese Society for Immunology,

  • Japanese Stomatological Society

  • Japanese Cancer Association

  • American Association of Immunologists

  • The Stomatological Society,Japan

  • Japanese Association of Oral Biology

  • Japanese Society of Oral Medicine

  • International Association of Dental Research

  • Japanese Association of Cancer Immunology

  • Japanese Society of Oral and Maxillofacial Surgenons

▼display all

Research Areas 【 display / non-display

  • Immunology

  • Oral pathobiological science

Qualification Acquired 【 display / non-display

  • Dentist


Published Papers & Misc 【 display / non-display

  1. Nakayama K, Nishijo T, Miyazawa M, Watabe T, Azuma M, Sakaguchi H. Hapten sensitization to vaginal mucosa induces less recruitment of dendritic cells accompanying TGF-β-expressing CD206<sup>+</sup> cells compared with skin. Immunity, inflammation and disease. 2022.04; 10 (4): e605. ( PubMed, DOI )

  2. Wongtim K, Ikeda E, Ohno T, Nagai S, Okuhara S, Kure K, Azuma M.. Overexpression of PD-L1 in gingival basal keratinocytes reduces periodontal inflammation in a ligature-induced periodontitis model. Journal of Periodontology. 2021.06; 93 (1): 146-155. ( PubMed, DOI )

  3. Takehara T, Wakamatsu E, Machiyama H, Nishi W, Emoto K, Azuma M, Soejima K, Fukunaga K, Yokosuka T. PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment. Communications biology. 2021.05; 4 (1): 581. ( PubMed, DOI )

  4. Ao X, Yang Y, Okiji T, Azuma M, Nagai S.. Polymorphonuclear Myeloid-derived cells that contribute to the immune paralysis are generated in the early phase of sepsis via PD-1/PD-L1 pathway. Infection and Immunity. 2021.05; 89 (6): e00771-20. ( PubMed, DOI )

  5. Azuma T, Sato Y, Ohno T, Azuma M, Kume H. Serum soluble B7-H3 is a prognostic marker for patients with non-muscle-invasive bladder cancer. PloS one. 2020.12; 15 (12): e0243379. ( PubMed, DOI )

  6. Yang Y, Nagai S, Kang S, Xia Y, Kawano Y, Miyake K, Karasuyama H, Azuma M. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting. International Immunology . 2020.07; 32 (8): 509-518. ( PubMed, DOI )

  7. J Rodriguez-Barbosa, Azuma M, Zelinskyy G, J Perez-Simon, M Del Rio. Critical role of PD-L1 expression on non-tumor cells rather than on tumor cells for effective anti-PD-L1 immunotherapy in a transplantable mouse hematopoietic tumor model. Cancer Immunol Immunother. 2020.06; 69 (6): 1001-1014. ( PubMed, DOI )

  8. Kashima Y, Nishii N, Tachinami H, Furusawa E, Nagai S, Harada H, Azuma M. Orthotopic tongue squamous cell carcinoma (SCC) model exhibiting a different tumor-infiltrating T-cell status with margin-restricted CD8+ T cells and regulatory T cell-dominance, compared to skin SCC. Biochem. Biophys. Res. Commun.. 2020.05; 526 (1): 218-224. ( PubMed, DOI )

  9. Eri Ikeda, Takahiko Shiba, Yuichi Ikeda, Wataru Suda, Akinori Nakasato, Yasuo Takeuchi, Miyuki Azuma, Masahira Hattori, Yuichi Izumi. Japanese subgingival microbiota in health vs disease and their roles in predicted functions associated with periodontitis. Odontology. 2020.04; 108 (2): 280-291. ( PubMed, DOI )

  10. Kunishige T, Taniguchi H, Ohno T, Azuma M, Hori J. VISTA is crucial for corneal allograft survival and maintenance of immune privilege. Invest Ophthalmol Vis Sci. 2019.12; 60 (15): 4958-4965. ( PubMed, DOI )

  11. Azuma M. Co-signal molecules in T-cell activation : Historical overview and perspective. Adv Exp Med Biol.. 2019.11; 1189 3-23. ( PubMed, DOI )

  12. Nagai S, Azuma M. The CD28-B7 family of co-signaling molecules. Adv Exp Med Biol.. 2019.11; 1189 25-51. ( PubMed, DOI )

  13. Furusawa E, Ohno T, Nagai S, Noda T, Komiyama T, Kobayashi K, Hamamoto H, Miyashin M, Yokozeki H, Azuma M. Silencing of PD-L2/B7-DC by topical application of small interfering RNA inhibits elicitation of contact hypersensitivity. J Invest Dermatol. 2019.10; 139 (10): 2164-2173. ( PubMed, DOI )

  14. Xia Y, Ohno T, Nishii N, Bhingare A, Tachinami H, Kashima Y, Nagai S, Saito H, Nakae S, Azuma M. T cell antitumor responses overcoming pro-tumor effects by regulatory T cells in a colon carcinoma model. Biochem Biophys Res Commun. 2019.10; 518 (2): 331-336. ( PubMed, DOI )

  15. Vu CTB, Thammahong A, Yagita H, Azuma M, Hirankarn N, Ritprajak P, Leelahavanichkul A. Blockade of PD-1 attenuated post-sepsis aspergillosis via the activation of IFN-γ and the dampening of IL-10. Shock. 2019.07; 11 ( PubMed, DOI )

  16. Furusawa Emi, Ohno Tatsukuni, Nagai Shigenori, Noda Taisei, Komiyama Takuya, Kobayashi Katsunori, Hamamoto Hidetoshi, Miyashin Michiyo, Yokozeki Hiroo, Azuma Miyuki. Silencing of PD-L2/B7-DC by Topical Application of Small Interfering RNA Inhibits Elicitation of Contract Hypersensitivity JOURNAL OF IMMUNOLOGY. 2019.05; 202 (1):

  17. Tachinami H, Nishii N, Xia Y, Kashima Y, Ohno T, Nagai S, Li L, Lau W, Tomihara K, Noguchi M, Azuma M. Differences of tumor-recruiting myeloid cells in murine squamous cell carcinoma influence the efficacy of immunotherapy combined with a TLR7 agonist and PD-L1 blockade. Oral Oncol.. 2019.04; 91 21-28. ( PubMed, DOI )

  18. Copland A, Sparrow A, Hart P, Diogo GR, Paul M, Azuma M, Reljic R. Bacillus calmette-guérin induces PD-L1 expression on antigen-presenting cells via autocrine and paracrine interleukin-STAT3 circuits. Sci Rep. 2019.03; 9 (1): 3655. ( PubMed, DOI )

  19. Ikeda E, Shiba T, Ikeda Y, Suda W, Nakasato A, Takeuchi Y, Azuma M, Hattori M, Izumi Y. Deep sequencing reveals specific bacterial signatures in the subgingival microbiota of healthy subjects. Clin Oral Investig. 2019.03; 23 (3): 1489-1493. ( PubMed, DOI )

  20. Mulati K, Hamanishi J, Matsumura N, Chamoto K, Mise N, Abiko K, Baba T, Yamaguchi K, Horikawa N, Murakami R, Taki M, Budiman K, Zeng X, Hosoe Y, Azuma M, Konishi I, Mandai M. VISTA expressed in tumour cells regulates T cell function. Br J Cancer. 2019.01; 120 (1): 115-127. ( PubMed, DOI )

  21. Murat K, Hamanishi J, Matsumura N, Chamoto K, Mise N, Abiko K, Baba T, Yamaguchi K, Murakami R, Hosoe Y, Azuma M, Konishi I, Mandai M. VISTA expressed in tumor cells regulates T cell function Cancer Science. 2018.12; 109 1323.

  22. Azuma T, Sato Y, Ohno T,Azuma M, Kume H.. Serum soluble B7-H4 is a prognostic marker for patients with non –metastatic clear cell renal cell carcinoma. Plos One. 2018.07; 13 (7): e01997119. ( DOI )

  23. Nishii N., Tachinami H., Kondo Y., Xia Y., Kashima Y., Ohno T., Nagai S., Li L., Lau W., Harada H., Azuma M.. Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy EUROPEAN JOURNAL OF IMMUNOLOGY. 2018.05; 48 71-72.

  24. Furusawa E., Ohno T., Miyashin M., Azuma M.. Topical application of B7-DC/PD-L2 siRNA inhibits contact hypersensitivity EUROPEAN JOURNAL OF IMMUNOLOGY. 2018.05; 48 52-53.

  25. Nishii N, Tachinami H, Kondo Y, Xia Y, Kashima Y, Ohno T, Nagai S, Li L, Lau W, Harada H, Azuma M. Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy. Oncotarget. 2018.03; 9 (17): 13301-13312. ( PubMed, DOI )

  26. Ohno T, Zhang C, Kondo Y, Kang S, Furusawa E, Tsuchiya K, Miyazaki Y, Azuma M. The immune checkpoint molecule VISTA regulates allergen-specific Th2-mediated immune responses. Int Immune. 2018.02; 30 (1): 3-11. ( PubMed, DOI )

  27. Azuma T, Sato Y, Ohno T, Azuma M, Kume H. Serum soluble B7-H4 is a prognostic marker for patients with non-metastatic clear cell renal cell carcinoma. PloS one. 2018; 13 (7): e0199719. ( PubMed, DOI )

  28. Sugita J, Asada Y, Ishida W, Iwamoto S, Sudo K, Suto H, Matsunaga T, Fukuda K, Fukushima A, Yokoi N, Ohno T, Azuma M, Ebihara N, Saito H, Kubo M, Nakae S, Matsuda A. Contributions of interleukin-33 and TSLP in a papain-soaked contact lens-induced mouse conjunctival inflammation model. Immun Inflamm Dis. 2017.12; 5 (4): 515-525. ( PubMed, DOI )

  29. Swangphon P, Pientong C, Sunthamala N, Bumrungthai S, Azuma M, Kleebkaow P, Tangsiriwatthana T, Sangkomkamhang U, Kongyingyoes B, Ekalaksananan T. Correlation of circulating CD64+/CD63+ monocyte ratio and stroma/peri-tumoral CD163+ monocyte density with human papillomavirus infected cervical lesion severity. Cancer Microenvironment. 2017.12; 10 (1-3): 77-85. ( PubMed, DOI )

  30. Nagai Shigenori, Adiba Nadya Niken, Tezuka Hiroyuki, Ohteki Toshiaki, Matsuda Satoshi, Azuma Miyuki. PI3K-Akt pathway enhances Tr1 differentiation induced by IL-27 CYTOKINE. 2017.12; 100 173.

  31. Nadya NA, Tezuka H, Ohteki T, Matsuda S, Azuma M, Nagai S. PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells. Immunology. 2017.11; 152 (3): 507-516. ( PubMed, DOI )

  32. Hirunwidchayarat W, Furusawa E, Kang S, Ohno T, Takeuchi S, Rungsiyanont S, Azuma M. Site-specific regulation of oral mucosa-recruiting CD8 T cells in a mouse contact allergy model. Biochem Biophys Res Commun. 2017.09; 490 (4): 1294-1300. ( PubMed, DOI )

  33. De Riva A, Wallberg M, Ronchi F, Coulson R, Sage A, Thorne L, Goodfellow L, McCoy K, Azuma M, Cooke A, Busch R. Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment. Plos One. 2017.08; 12 (8): e0181964. ( PubMed, DOI )

  34. Wallberg M, Recino A, Phillips J, Howie D, Vienne M, Paluch C, Azuma M, Wong FS, Waldmann H, Cooke A. Anti-CD3 treatment up-regulates programmed cell death protein-1 expression on activated effector T cells and severely impairs their inflammatory capacity. Immunology. 2017.06; 151 (2): 248-260. ( PubMed, DOI )

  35. Ohno T, Kondo Y, Zhang C, Kang S, Azuma M. Immune checkpoint molecule, VISTA regulates T cell-mediated skin inflammatory responses. J Invest Dermatol . 2017.06; 137 (6): 1384-1386. ( PubMed, DOI )

  36. Taniguchi Hiroko, Hase Hidenori, Akiba Hisaya, Yagita Hideo, Azuma Miyuki, Hori Junko. Role of B7-H3/TLT-2 pathway in immune privilege of corneal allografts INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2017.06; 58 (8):

  37. Kang S, Zhang C, Ohno T, Azuma M. Unique B7-H1 expression on masticatory mucosae in the oral cavity and trans-coinhibition by B7-H1-expressing keratinocytes regulating CD4+ T-cell-mediated mucosal tissue inflammation. Mucosal Immunol. 2017.05; 10 (3): 650-660. ( PubMed, DOI )

  38. Kang S., Zhang C., Ohno T., Azuma M.. Unique B7-H1 expression on masticatory mucosae in the oral cavity and trans-coinhibition by B7-H1-expressing keratinocytes regulating CD4(+) T cell-mediated mucosal tissue inflammation MUCOSAL IMMUNOLOGY. 2017.05; 10 (3): 650-660. ( DOI )

  39. Vo M, Holz LE, Wong YC, English K, Benseler V, McGuffog C, Azuma M, McGaughan GW, Bowen DG, Bertolino P. Effector T cell function rather than survival determines extent and duration of hepatitis in mice. J Hapatol. 2016; 64 1327-1338.

  40. Kurebayashi Y, Baba Y, Minowa A, Nadya NA, Azuma M, Yoshimura A, Koyasu S, Nagai S. TGF-β-induced phosphorylation of akt and foxo transcription factors negatively regulates the differentiation of induced regulatory T cells. Biochem Biophys Res Commun. 2016; 480 (1): 114-119. ( DOI )

  41. Kondo Y, Ohno T, Nishii N, Harada K, Yagita H, Azuma M. Differential contribution of three immune checkpoint (VISTA, CTLA-4, PD-1) pathways to antitumor responses against squamous cell carcinoma. Oral Oncology. 2016; 57 54-60. ( DOI )

  42. Ooi JD, Li M, Kourkoutzelos K, Yagita H, Azuma M, Holdsworth SR, Kitching AR. Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis. Nephrology (Carlton). 2015.12; 20 (12): 892-898. ( PubMed, DOI )

  43. Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S. An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic inflammation by promoting regulatory T cell numbers Immunity. 2015.07; 43 (1): 175-186. ( PubMed )

  44. McAlees JW, Lajoie S, Dienger K, Sproles AA, Richgels PK, Yang Y, Khodoun M, Azuma M, Yagita H, Fulkerson PC, Wills-Karp M, Lewkowich IP. Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma. Eur. J. Immunol. 2015.04; 45 (4): 1019-1029. ( PubMed, DOI )

  45. Patcharee R, Azuma M. Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. Oral Oncol. 2015.03; 51 (3): 221-228. ( PubMed )

  46. Zhang C, Ohno T, Kang S, Takai T, Azuma M. Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets. Vaccine. 2014.09; 32 (43): 5669-5676. ( PubMed, DOI )

  47. Fujiwara H, Maeda Y, Kobayashi K, Nishimori H, Matsuoka K, Fujii N, Kondo E, Tanaka T, Chen L, Azuma M, Yagita H, Tanimoto M. Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease. J. Immunol. 2014.09; 193 (5): 2565-2573. ( PubMed, DOI )

  48. Sunthamala N, Pientong C, Ohno T, Zhang C, Bhingare AC, Kondo Y, Azuma M, Ekalaksananan T. HPV16 E2 protein promotes innate immunity by modulating immunosuppressive status. Biochem. Biophys. Res. Commun.. 2014.04; 446 (4): 977-982. ( PubMed, DOI )

  49. Bhingare AC, Ohno T, Tomura M, Zhang C, Aramaki O, Otsuki M, Tagami J, Azuma M. Dental pulp dendritic cells migrate to regional lymph nodes. J. Dent. Res.. 2014.03; 93 (3): 288-293. ( PubMed, DOI )

  50. Asim Saha, Kazutoshi Aoyama, Patricia A Taylor, Brent H Koehn, Rachelle G Veenstra, Angela Panoskaltsis-Mortari, David H Munn, William J Murphy, Miyuki Azuma, Hideo Yagita, Brian T Fife, Mohammed H Sayegh, Nader Najafian, Gerard Socie, Rafi Ahmed, Gordon J Freeman, Arlene H Sharpe, Bruce R Blazar. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood. 2013.10; 122 (17): 3062-3073. ( PubMed, DOI )

  51. Kristen E Pauken, Marc K Jenkins, Miyuki Azuma, Brian T Fife. PD-1, but not PD-L1, expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes. Diabetes. 2013.08; 62 (8): 2859-2869. ( PubMed, DOI )

  52. Nienke van der Werf, Stephen A Redpath, Miyuki Azuma, Hideo Yagita, Matthew D Taylor. Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection. PLoS Pathog.. 2013.03; 9 (3): e1003215. ( PubMed, DOI )

  53. Benjamin Joachim Schmiedel, Tina Nuebling, Julia Steinbacher, Alexandra Malinovska, Constantin Maximilian Wende, Miyuki Azuma, Pascal Schneider, Ludger Grosse-Hovest, Helmut Rainer Salih. Receptor activator for NF-κB ligand in acute myeloid leukemia: expression, function, and modulation of NK cell immunosurveillance. J. Immunol.. 2013.01; 190 (2): 821-831. ( PubMed, DOI )

  54. Benjamin Joachim Schmiedel, Carolin Andrea Scheible, Tina Nuebling, Hans-Georg Kopp, Stefan Wirths, Miyuki Azuma, Pascal Schneider, Gundram Jung, Ludger Grosse-Hovest, Helmut Rainer Salih. RANKL expression, function, and therapeutic targeting in multiple myeloma and chronic lymphocytic leukemia. Cancer Res.. 2013.01; 73 (2): 683-694. ( PubMed, DOI )

  55. Takuya Ueno, Melissa Y Yeung, Martina McGrath, Sunmi Yang, Nadia Zaman, Benjamin Snawder, Robert F Padera, Ciara N Magee, Rostic Gorbatov, Masaaki Hashiguchi, Miyuki Azuma, Gordon J Freeman, Mohamed H Sayegh, Nader Najafian. Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses. Eur. J. Immunol.. 2012.09; 42 (9): 2343-2353. ( PubMed, DOI )

  56. Takeshi Isoda, Masatoshi Takagi, Jinhua Piao, Shun Nakagama, Masaki Sato, Kyoko Masuda, Tomokatsu Ikawa, Miyuki Azuma, Tomohiro Morio, Hiroshi Kawamoto, Shuki Mizutani. Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM. Blood. 2012.07; 120 (4): 789-799. ( PubMed, DOI )

  57. Tadashi Yokosuka, Masako Takamatsu, Wakana Kobayashi-Imanishi, Akiko Hashimoto-Tane, Miyuki Azuma, Takashi Saito. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J. Exp. Med.. 2012.06; 209 (6): 1201-1217. ( PubMed, DOI )

  58. 186. Hashiguchi M, Inamochi Y, Nagai S, Otsuki N, Piao J, Kobori H, Kanno Y, Kojima H, Kobata T, Azuma M.. Human B7-H3 binds to Triggering receptor expressed on myeloid cells-like transcript 2 (TLT-2) and enhances T cell responses. 2012.02; 2 (1): 9-16. ( DOI )

  59. Patcharee Ritprajak, Masaaki Hashiguchi, Hisaya Akiba, Hideo Yagita, Ko Okumura, Miyuki Azuma. Antibodies against B7-DC with differential binding properties exert opposite effects. Hybridoma (Larchmt). 2012.02; 31 (1): 40-47. ( PubMed, DOI )

  60. Francesca D'Addio, Leonardo V Riella, Bechara G Mfarrej, Lola Chabtini, La Tonya Adams, Melissa Yeung, Hideo Yagita, Miyuki Azuma, Mohamed H Sayegh, Indira Guleria. The link between the PDL1 costimulatory pathway and Th17 in fetomaternal tolerance. J. Immunol.. 2011.11; 187 (9): 4530-4541. ( PubMed, DOI )

  61. Stephen A Newland, Jenny M Phillips, Pietro Mastroeni, Miyuki Azuma, Paola Zaccone, Anne Cooke. PD-L1 blockade overrides Salmonella typhimurium-mediated diabetes prevention in NOD mice: no role for Tregs. Eur. J. Immunol.. 2011.10; 41 (10): 2966-2976. ( PubMed, DOI )

  62. Jang-Jaer Lee, Yen-Liang Chang, Wan-Ling Lai, Jenq-Yuh Ko, Mark Yen-Ping Kuo, Chun-Pin Chiang, Miyuki Azuma, Ching-Wen Chen, Jean-San Chia. Increased prevalence of interleukin-17-producing CD4(+) tumor infiltrating lymphocytes in human oral squamous cell carcinoma. Head Neck. 2011.09; 33 (9): 1301-1308. ( PubMed, DOI )

  63. Oto Aramaki, Narumon Chalermsarp, Masayuki Otsuki, Junji Tagami, Miyuki Azuma. Differential expression of co-signal molecules and migratory properties in four distinct subsets of migratory dendritic cells from the oral mucosa. Biochem. Biophys. Res. Commun.. 2011.09; 413 (3): 407-413. ( PubMed, DOI )

  64. Jun Yang, Leonardo V Riella, Susanne Chock, Tao Liu, Xiaozhi Zhao, Xueli Yuan, Alison M Paterson, Toshihiko Watanabe, Vijay Vanguri, Hideo Yagita, Miyuki Azuma, Bruce R Blazar, Gordon J Freeman, Scott J Rodig, Arlene H Sharpe, Anil Chandraker, Mohamed H Sayegh. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J. Immunol.. 2011.08; 187 (3): 1113-1119. ( PubMed, DOI )

  65. Nienke van der Werf, Stephen A Redpath, Alexander T Phythian-Adams, Miyuki Azuma, Judith E Allen, Rick M Maizels, Andrew S Macdonald, Matthew D Taylor. Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo. J. Immunol.. 2011.08; 187 (3): 1411-1420. ( PubMed, DOI )

  66. Yujia Cao, Lu Zhang, Pacharee Ritprajak, Fumihiko Tsushima, Pornpan Youngnak-Piboonratanakit, Yosuke Kamimura, Masaaki Hashiguchi, Miyuki Azuma. Immunoregulatory molecule B7-H1 (CD274) contributes to skin carcinogenesis. Cancer Res.. 2011.07; 71 (14): 4737-4741. ( PubMed, DOI )

  67. Koichiro Matsumoto, Keiko Kan-O, Miyuki Eguchi-Tsuda, Satoru Fukuyama, Yukari Asai, Takafumi Matsumoto, Atsushi Moriwaki, Yuko Matsunaga, Hiroko Tsutsui, Taro Kawai, Osamu Takeuchi, Shizuo Akira, Hideo Yagita, Miyuki Azuma, Yoichi Nakanishi, Hiromasa Inoue. Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice. Am. J. Respir. Cell Mol. Biol.. 2011.07; 45 (1): 31-39. ( PubMed, DOI )

  68. Emily Hams, Mark J McCarron, Sylvie Amu, Hideo Yagita, Miyuki Azuma, Lieping Chen, Padraic G Fallon. Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells. J. Immunol.. 2011.05; 186 (10): 5648-5655. ( PubMed, DOI )

  69. Fredy R S Gutierrez, Flávia S Mariano, Carlo J F Oliveira, Wander R Pavanelli, Paulo M M Guedes, Grace K Silva, Ana P Campanelli, Cristiane M Milanezi, Miyuki Azuma, Tasuku Honjo, Mauro M Teixeira, Julio C S Aliberti, João S Silva. Regulation of Trypanosoma cruzi-induced myocarditis by programmed death cell receptor 1. Infect. Immun.. 2011.05; 79 (5): 1873-1881. ( PubMed, DOI )

  70. Qing Zhou, Meghan E Munger, Rachelle G Veenstra, Brenda J Weigel, Mitsuomi Hirashima, David H Munn, William J Murphy, Miyuki Azuma, Ana C Anderson, Vijay K Kuchroo, Bruce R Blazar. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood. 2011.04; 117 (17): 4501-4510. ( PubMed, DOI )

  71. Tatsukuni Ohno, Keisuke Oboki, Hideaki Morita, Naoki Kajiwara, Ken Arae, Shizuko Tanaka, Masako Ikeda, Motoyasu Iikura, Taishin Akiyama, Jun-ichiro Inoue, Kenji Matsumoto, Katsuko Sudo, Miyuki Azuma, Ko Okumura, Thomas Kamradt, Hirohisa Saito, Susumu Nakae. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation. PLoS ONE. 2011; 6 (4): e18404. ( PubMed, DOI )

  72. Cao Y, Zhang L, Kamimura Y, Ritprajak P, Hashiguchi M, Hirose S, Azuma M. B7-H1 overexpression regulates epithelial -mesenchymal transition and accelerates carcinogenesis in skin. Cancer Res. 2010.12; ( PubMed, DOI )

  73. Junko Hori, Hiroko Taniguchi, Mingcong Wang, Masamichi Oshima, Miyuki Azuma. GITR ligand-mediated local expansion of regulatory T cells and immune privilege of corneal allografts. Invest. Ophthalmol. Vis. Sci.. 2010.12; 51 (12): 6556-6565. ( PubMed, DOI )

  74. Yamaura K, Watanabe T, Boenisch O, Yeung M, Yang S, Magee CN, Padera R, Datta S, Schatton T, Kamimura Y, Azuma M, Najafian N. In vivo function of immune inhibitory molecule b7-h4 in alloimmune responses. Am J Transplant. 2010.10; 10 (10): 2355-2362. ( PubMed, DOI )

  75. Qing Zhou, Meghan E Munger, Steven L Highfill, Jakub Tolar, Brenda J Weigel, Megan Riddle, Arlene H Sharpe, Daniel A Vallera, Miyuki Azuma, Bruce L Levine, Carl H June, William J Murphy, David H Munn, Bruce R Blazar. Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood. 2010.10; 116 (14): 2484-2493. ( PubMed, DOI )

  76. Tomohiro Fukaya, Hideaki Takagi, Yumiko Sato, Kaori Sato, Kawori Eizumi, Honami Taya, Tahiro Shin, Lieping Chen, Chen Dong, Miyuki Azuma, Hideo Yagita, Bernard Malissen, Katsuaki Sato. Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance. Blood. 2010.09; 116 (13): 2266-2276. ( PubMed, DOI )

  77. Oliver T Burton, Paola Zaccone, Jenny M Phillips, Hugo De La Peña, Zoltán Fehérvári, Miyuki Azuma, Sarah Gibbs, Brigitta Stockinger, Anne Cooke. Roles for TGF-beta and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice. J. Immunol.. 2010.09; 185 (5): 2754-2762. ( PubMed, DOI )

  78. Peter Dias, Francesca Giannoni, Lian Ni Lee, Dongun Han, Sorah Yoon, Hideo Yagita, Miyuki Azuma, Sally R Sarawar. CD4 T-cell help programs a change in CD8 T-cell function enabling effective long-term control of murine gammaherpesvirus 68: role of PD-1-PD-L1 interactions. J. Virol.. 2010.08; 84 (16): 8241-8249. ( PubMed, DOI )

  79. Kobori H, Hashiguchi M, Piao J, Kato M, Ritprajak P, Azuma M. Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites. Immunology. 2010.07; 130 (3): 363-373. ( PubMed, DOI )

  80. Ritprajak P, Hashiguchi M, Tsushima F, Chalermsarp N, Azuma M. Keratinocyte-associated B7-H1 directly regulates cutaneous effector CD8+ T cell responses. J Immunol. 2010.05; 184 (9): 4918-4925. ( PubMed, DOI )

  81. M Morita, M Fujino, G Jiang, Y Kitazawa, L Xie, M Azuma, H Yagita, S Nagao, A Sugioka, Y Kurosawa, S Takahara, J Fung, S Qian, L Lu, X-K Li. PD-1/B7-H1 interaction contribute to the spontaneous acceptance of mouse liver allograft. Am. J. Transplant.. 2010.01; 10 (1): 40-46. ( PubMed, DOI )

  82. Azuma M, Ritprajak P, Hashiguchi M. Topical application of siRNA targeting cutaneous dendritic cells in allergic skin disease. Methods Mol Biol. 2010; 623 373-381. ( PubMed, DOI )

  83. Miyuki Azuma. Role of the glucocorticoid-induced TNFR-related protein (GITR)-GITR ligand pathway in innate and adaptive immunity. Crit. Rev. Immunol.. 2010; 30 (6): 547-557. ( PubMed )

  84. Kamimura Y, Kobori H, Piao J, Hashiguchi M, Matsumoto K, Hirose S, Azuma M. Possible involvement of soluble B7-H4 in T cell-mediated inflammatory immune responses. Biochem Biophys Res Commun. 2009.11; 389 (2): 349-353. ( PubMed, DOI )

  85. Brian T Fife, Kristen E Pauken, Todd N Eagar, Takashi Obu, Jenny Wu, Qizhi Tang, Miyuki Azuma, Matthew F Krummel, Jeffrey A Bluestone. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat. Immunol.. 2009.11; 10 (11): 1185-1192. ( PubMed, DOI )

  86. Keisuke Okudaira, Ryota Hokari, Yoshikazu Tsuzuki, Yoshikiyo Okada, Shunsuke Komoto, Chikako Watanabe, Chie Kurihara, Atsushi Kawaguchi, Shigeaki Nagao, Miyuki Azuma, Hideo Yagita, Soichiro Miura. Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model. Int. J. Oncol.. 2009.10; 35 (4): 741-749. ( PubMed )

  87. Pornpan Youngnak-Piboonratanakit, Kittipong Dhanuthai, Kobkan Thongprasom, Pimporn Luckprom, Wilairat Sarideechaigul, Lakana Luangjarmekorn, Miyuki Azuma. Expression of IFN-gamma before and after treatment of oral lichen planus with 0.1% fluocinolone acetonide in orabase. J. Oral Pathol. Med.. 2009.10; 38 (9): 689-694. ( PubMed, DOI )

  88. Piao J, Kamimura Y, Iwai H, Cao Y, Kikuchi K, Hashiguchi M, Masunaga T, Jiang H, Tamura K, Sakaguchi S, Azuma M. Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours. Immunology. 2009.08; 127 (4): 489-499. ( PubMed, DOI )

  89. Chalermsarp N, Azuma M. Identification of three distinct subsets of migrating dendritic cells from oral mucosa within the regional lymph nodes. Immunology. 2009.08; 127 (4): 558-566. ( PubMed, DOI )

  90. Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, Azuma M, Lee SK, Mizutani S, Morio T. Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol. 2009.05; 182 (9): 5515-5527. ( PubMed, DOI )

  91. Masafumi Nakayama, Hisaya Akiba, Kazuyoshi Takeda, Yuko Kojima, Masaaki Hashiguchi, Miyuki Azuma, Hideo Yagita, Ko Okumura. Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation. Blood. 2009.04; 113 (16): 3821-3830. ( PubMed, DOI )

  92. Kamimura Y, Iwai H, Piao J, Hashiguchi M, Azuma M. The glucocorticoid-induced TNF receptor-related protein (GITR)-GITR ligand pathway acts as a mediator of cutaneous dendritic cell migration and promotes T cell-mediated acquired immunity. J Immunol. 2009.03; 182 (5): 2708-2716. ( PubMed, DOI )

  93. Vrajesh V Parekh, Saif Lalani, Sungjune Kim, Ramesh Halder, Miyuki Azuma, Hideo Yagita, Vipin Kumar, Lan Wu, Luc Van Kaer. PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J. Immunol.. 2009.03; 182 (5): 2816-2826. ( PubMed, DOI )

  94. Deepak Yadav, Natasha Hill, Hideo Yagita, Miyuki Azuma, Nora Sarvetnick. Altered availability of PD-1/PD ligands is associated with the failure to control autoimmunity in NOD mice. Cell. Immunol.. 2009; 258 (2): 161-171. ( PubMed, DOI )

  95. M Okano, N Otsuki, M Azuma, T Fujiwara, S Kariya, Y Sugata, T Higaki, K Kino, Y Tanimoto, K Okubo, K Nishizaki. Allergen-specific immunotherapy alters the expression of B and T lymphocyte attenuator, a co-inhibitory molecule, in allergic rhinitis. Clin. Exp. Allergy. 2008.12; 38 (12): 1891-1900. ( PubMed, DOI )

  96. Woo-Sung Chang, Ji-Yeon Kim, Yeon-Jeong Kim, Yun-Sun Kim, Jung-Mi Lee, Miyuki Azuma, Hideo Yagita, Chang-Yuil Kang. Cutting edge: Programmed death-1/programmed death ligand 1 interaction regulates the induction and maintenance of invariant NKT cell anergy. J. Immunol.. 2008.11; 181 (10): 6707-6710. ( PubMed )

  97. Hashiguchi M, Kobori H, Ritprajak P, Kamimura Y, Kozono H, Azuma M. Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. Proc Natl Acad Sci U S A. 2008.07; 105 (30): 10495-10500. ( PubMed, DOI )

  98. Ritprajak P, Hashiguchi M, Azuma M. Topical application of cream-emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cells. Mol Ther. 2008.07; 16 (7): 1323-1330. ( PubMed, DOI )

  99. Igarashi H, Cao Y, Iwai H, Piao J, Kamimura Y, Hashiguchi M, Amagasa T, Azuma M. GITR ligand-costimulation activates effector and regulatory functions of CD4+ T cells. Biochem Biophys Res Commun. 2008.05; 369 (4): 1134-1138. ( PubMed, DOI )

  100. Jun Yang, Joyce Popoola, Shakila Khandwala, Nidyanandh Vadivel, Vijay Vanguri, Xueli Yuan, Shirine Dada, Indira Guleria, Chaorui Tian, M Javeed Ansari, Tahiro Shin, Hideo Yagita, Miyuki Azuma, Mohamed H Sayegh, Anil Chandraker. Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy. Circulation. 2008.02; 117 (5): 660-669. ( PubMed, DOI )

  101. Koichiro Matsumoto, Satoru Fukuyama, Miyuki Eguchi-Tsuda, Takako Nakano, Takafumi Matsumoto, Mikiko Matsumura, Atsushi Moriwaki, Keiko Kan-o, Yoshihiro Wada, Hideo Yagita, Tahiro Shin, Drew M Pardoll, Rirprajak Patcharee, Miyuki Azuma, Yoichi Nakanishi, Hiromasa Inoue. B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma. Biochem. Biophys. Res. Commun.. 2008.01; 365 (1): 170-175. ( PubMed, DOI )

  102. Antje Habicht, Shirine Dada, Mollie Jurewicz, Brian T Fife, Hideo Yagita, Miyuki Azuma, Mohamed H Sayegh, Indira Guleria. A link between PDL1 and T regulatory cells in fetomaternal tolerance. J. Immunol.. 2007.10; 179 (8): 5211-5219. ( PubMed )

  103. Katsunori Tanaka, Monica J Albin, Xueli Yuan, Kazuhiro Yamaura, Antje Habicht, Takaya Murayama, Martin Grimm, Ana Maria Waaga, Takuya Ueno, Robert F Padera, Hideo Yagita, Miyuki Azuma, Tahiro Shin, Bruce R Blazar, David M Rothstein, Mohamed H Sayegh, Nader Najafian. PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection. J. Immunol.. 2007.10; 179 (8): 5204-5210. ( PubMed )

  104. Indira Guleria, Melanie Gubbels Bupp, Shirine Dada, Brian Fife, Qizhi Tang, Mohammed Javeed Ansari, Subbulaxmi Trikudanathan, Nidyanandh Vadivel, Paolo Fiorina, Hideo Yagita, Miyuki Azuma, Mark Atkinson, Jeffrey A Bluestone, Mohamed H Sayegh. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin. Immunol.. 2007.10; 125 (1): 16-25. ( PubMed, DOI )

  105. Madhav D Sharma, Babak Baban, Phillip Chandler, De-Yan Hou, Nagendra Singh, Hideo Yagita, Miyuki Azuma, Bruce R Blazar, Andrew L Mellor, David H Munn. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J. Clin. Invest.. 2007.09; 117 (9): 2570-2582. ( PubMed, DOI )

  106. Akira Kawano, Shinji Shimoda, Takashi Kamihira, Fumihiko Ishikawa, Hiroaki Niiro, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara, Minoru Nakamura, Atsumasa Komori, Kiyoshi Migita, Hiromi Ishibashi, Miyuki Azuma, M Eric Gershwin, Mine Harada. Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis. J. Immunol.. 2007.09; 179 (5): 3315-3324. ( PubMed )

  107. Juro Nakanishi, Yoshihiro Wada, Koichiro Matsumoto, Miyuki Azuma, Ken Kikuchi, Shoichi Ueda. Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers. Cancer Immunol. Immunother.. 2007.08; 56 (8): 1173-1182. ( PubMed, DOI )

  108. Tsunekazu Oikawa, Hiroki Takahashi, Tomohisa Ishikawa, Atsushi Hokari, Noriko Otsuki, Miyuki Azuma, Mikio Zeniya, Hisao Tajiri. Intrahepatic expression of the co-stimulatory molecules programmed death-1, and its ligands in autoimmune liver disease. Pathol. Int.. 2007.08; 57 (8): 485-492. ( PubMed, DOI )

  109. Tanaka K, Jinhua P, Omura K, Azuma M. Multipotency of CD11bhighGr-1+ immature myeloid cells accumulating in oral squamous cell carcinoma-bearing mice. Oral Oncol. 2007.07; 43 (6): 586-592. ( PubMed, DOI )

  110. Yoshinori Seko, Hideo Yagita, Ko Okumura, Miyuki Azuma, Ryozo Nagai. Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3. Cardiovasc. Res.. 2007.07; 75 (1): 158-167. ( PubMed, DOI )

  111. Yadav, D.Fine, C.Azuma, M.Sarvetnick, N.. B7-1 mediated costimulation regulates pancreatic autoimmunity Mol Immunol. 2007.04; 44 (10): 2616-2624.

  112. Nomi, T.Sho, M.Akahori, T.Hamada, K.Kubo, A.Kanehiro, H.Nakamura, S.Enomoto, K.Yagita, H.Azuma, M.Nakajima, Y.. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer Clin Cancer Res. 2007.04; 13 (7): 2151-2157.

  113. Kitazawa, Y.Fujino, M.Wang, Q.Kimura, H.Azuma, M.Kubo, M.Abe, R.Li, X. K.. Involvement of the programmed death-1/programmed death-1 ligand pathway in CD4+CD25+ regulatory T-cell activity to suppress alloimmune responses Transplantation. 2007.03; 83 (6): 774-782.

  114. Hori, J.Wang, M.Miyashita, M.Tanemoto, K.Takahashi, H.Takemori, T.Okumura, K.Yagita, H.Azuma, M.. B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts J Immunol. 2006.11; 177 (9): 5928-5935.

  115. Fife, B. T.Guleria, I.Gubbels Bupp, M.Eagar, T. N.Tang, Q.Bour-Jordan, H.Yagita, H.Azuma, M.Sayegh, M. H.Bluestone, J. A.. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway J Exp Med. 2006.11; 203 (12): 2737-2747.

  116. Azuma M. Fundamental mechanisms of host immune responses to infection. J Periodontal Res. 2006.10; 41 (5): 361-373. ( PubMed, DOI )

  117. Oikawa T, Kamimura Y, Akiba H, Yagita H, Okumura K, Takahashi H, Zeniya M, Tajiri H, Azuma M. Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease. J Immunol. 2006.10; 177 (7): 4281-4287. ( PubMed )

  118. Zhang J, Kawashima N, Suda H, Nakano Y, Takano Y, Azuma M. The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties. Int Immunol. 2006.09; 18 (9): 1375-1384. ( PubMed, DOI )

  119. Fukushima, A.Yamaguchi, T.Azuma, M.Yagita, H.Ueno, H.. Involvement of programmed death-ligand 2 (PD-L2) in the development of experimental allergic conjunctivitis in mice Br J Ophthalmol. 2006.08; 90 (8): 1040-1045.

  120. Otsuki N, Kamimura Y, Hashiguchi M, Azuma M. Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells. Biochem Biophys Res Commun. 2006.06; 344 (4): 1121-1127. ( PubMed, DOI )

  121. Youngnak-Piboonratanakit P, Tsushima F, Otsuki N, Igarashi H, Omura K, Azuma M. Expression and regulation of human CD275 on endothelial cells in healthy and inflamed mucosal tissues. Scand J Immunol. 2006.03; 63 (3): 191-198. ( PubMed, DOI )

  122. Tsushima F, Tanaka K, Otsuki N, Youngnak P, Iwai H, Omura K, Azuma M. Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma. Oral Oncol. 2006.03; 42 (3): 268-274. ( PubMed, DOI )

  123. Zhu, B.Guleria, I.Khosroshahi, A.Chitnis, T.Imitola, J.Azuma, M.Yagita, H.Sayegh, M. H.Khoury, S. J.. Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis J Immunol. 2006.03; 176 (6): 3480-3489.

  124. Yamazaki, T.Akiba, H.Koyanagi, A.Azuma, M.Yagita, H.Okumura, K.. Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production J Immunol. 2005.08; 175 (3): 1586-1592.

  125. Guleria, I.Khosroshahi, A.Ansari, M. J.Habicht, A.Azuma, M.Yagita, H.Noelle, R. J.Coyle, A.Mellor, A. L.Khoury, S. J.Sayegh, M. H.. A critical role for the programmed death ligand 1 in fetomaternal tolerance J Exp Med. 2005.07; 202 (2): 231-237.

  126. Ito, T.Ueno, T.Clarkson, M. R.Yuan, X.Jurewicz, M. M.Yagita, H.Azuma, M.Sharpe, A. H.Auchincloss, H., Jr.Sayegh, M. H.Najafian, N.. Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo J Immunol. 2005.06; 174 (11): 6648-6656.

  127. Sandner, S. E.Clarkson, M. R.Salama, A. D.Sanchez-Fueyo, A.Domenig, C.Habicht, A.Najafian, N.Yagita, H.Azuma, M.Turka, L. A.Sayegh, M. H.. Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo J Immunol. 2005.05; 174 (6): 3408-3415.

  128. Tsuda, M.Matsumoto, K.Inoue, H.Matsumura, M.Nakano, T.Mori, A.Azuma, M.Nakanishi, Y.. Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA Biochem Biophys Res Commun. 2005.04; 330 (1): 263-270.

  129. Ohigashi, Y.Sho, M.Yamada, Y.Tsurui, Y.Hamada, K.Ikeda, N.Mizuno, T.Yoriki, R.Kashizuka, H.Yane, K.Tsushima, F.Otsuki, N.Yagita, H.Azuma, M.Nakajima, Y.. Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer Clin Cancer Res. 2005.04; 11 (8): 2947-2953.

  130. Kojima T, Aoki K, Nonaka K, Saito H, Azuma M, Iwai H, Varghese BJ, Yoshimasu H, Baron R, Ohya K, Amagasa T. Subcutaneous injections of a TNF-alpha antagonistic peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis. J Med Dent Sci. 2005.03; 52 (1): 91-99. ( PubMed )

  131. 張  健、東 みゆき. 歯髄における免疫応答メカニズムを考えるために 樹状細胞は何をしているのか? The Quintessence. 2005; 24 1375-1382.

  132. 神村 洋介、東 みゆき. 新しいB7ファミリー分子の機能 炎症と免疫. 2005; 13 676-682.

  133. Koga N, Suzuki J, Kosuge H, Haraguchi G, Onai Y, Futamatsu H, Maejima Y, Gotoh R, Saiki H, Tsushima F, Azuma M, Isobe M. Blockade of the interaction between PD-1 and PD-L1 accelerates graft arterial disease in cardiac allografts. Arterioscler Thromb Vasc Biol. 2004.11; 24 (11): 2057-2062. ( PubMed, DOI )

  134. Nagahama K, Aoki K, Nonaka K, Saito H, Takahashi M, Varghese BJ, Shimokawa H, Azuma M, Ohya K, Ohyama K. The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis. Bone. 2004.11; 35 (5): 1059-1068. ( PubMed, DOI )

  135. Tani, K.Azuma, M.Nakazaki, Y.Oyaizu, N.Hase, H.Ohata, J.Takahashi, K.OiwaMonna, M.Hanazawa, K.Wakumoto, Y.Kawai, K.Noguchi, M.Soda, Y.Kunisaki, R.Watari, K.Takahashi, S.Machida, U.Satoh, N.Tojo, A.Maekawa, T.Eriguchi, M.Tomikawa, S.Tahara, H.Inoue, Y.Yoshikawa, H.Yamada, Y.Iwamoto, A.Hamada,Yamashita, N.Okumura, K.Kakizoe, T.Akaza, H.Fujime, M.Clift, S.Ando, D.Mulligan, R.Asano, S.. Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: clinical and immunological findings Mol Ther. 2004.10; 10 (4): 799-816.

  136. Zhou X, Kubo M, Nishitsuji H, Kurihara K, Ikeda T, Ohashi T, Azuma M, Masuda T, Kannagi M. Inducible-costimulator-mediated suppression of human immunodeficiency virus type 1 replication in CD4(+) T lymphocytes. Virology. 2004.08; 325 (2): 252-263. ( PubMed, DOI )

  137. Oei, E.Kalb, T.Beuria, P.Allez, M.Nakazawa, A.Azuma, M.Timony, M.Stuart, Z.Chen, H.Sperber, K.. Accessory cell function of airway epithelial cells Am J Physiol Lung Cell Mol Physiol. 2004.08; 287 (2): 318-331.

  138. Konishi, J.Yamazaki, K.Azuma, M.Kinoshita, I.Dosaka-Akita, H.Nishimura, M.. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression Clin Cancer Res. 2004.08; 10 (15): 5094-5100.

  139. Youngnak-Piboonratanakit P, Tsushima F, Otsuki N, Igarashi H, Machida U, Iwai H, Takahashi Y, Omura K, Yokozeki H, Azuma M. The expression of B7-H1 on keratinocytes in chronic inflammatory mucocutaneous disease and its regulatory role. Immunol Lett. 2004.07; 94 (3): 215-222. ( PubMed, DOI )

  140. Kanamaru F, Iwai H, Ikeda T, Nakajima A, Ishikawa I, Azuma M. Expression of membrane-bound and soluble receptor activator of NF-kappaB ligand (RANKL) in human T cells. Immunol Lett. 2004.07; 94 (3): 239-246. ( PubMed, DOI )

  141. Kanamaru F, Youngnak P, Hashiguchi M, Nishioka T, Takahashi T, Sakaguchi S, Ishikawa I, Azuma M. Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J Immunol. 2004.06; 172 (12): 7306-7314. ( PubMed )

  142. Nakazawa, A.Dotan, I.Brimnes, J.Allez, M.Shao, L.Tsushima, F.Azuma, M.Mayer, L.. The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells Gastroenterology. 2004.05; 126 (5): 1347-1357.

  143. Hase, H.Kanno, Y.Kojima, M.Hasegawa, K.Sakurai, D.Kojima, H.Tsuchiya, N.Tokunaga, K.Masawa, N.Azuma, M.Okumura, K.Kobata, T.. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex Blood. 2004.03; 103 (6): 2257-2265.

  144. Koichiro Matsumoto, Hiromasa Inoue, Takako Nakano, Miyuki Tsuda, Yuki Yoshiura, Satoru Fukuyama, Fumihiko Tsushima, Tomoaki Hoshino, Hisamichi Aizawa, Hisaya Akiba, Drew Pardoll, Nobuyuki Hara, Hideo Yagita, Miyuki Azuma, Yoichi Nakanishi. B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism. J. Immunol.. 2004.02; 172 (4): 2530-2541. ( PubMed )

  145. Aramaki, O.Shirasugi, N.Takayama, T.Shimazu, M.Kitajima, M.Ikeda, Y.Azuma, M.Okumura, K.Yagita, H.Niimi, M.. Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen Transplantation. 2004.01; 77 (1): 6-12.

  146. Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol. 2003.10; 171 (8): 4156-4163. ( PubMed )

  147. Tsushima F, Iwai H, Otsuki N, Abe M, Hirose S, Yamazaki T, Akiba H, Yagita H, Takahashi Y, Omura K, Okumura K, Azuma M. Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. Eur J Immunol. 2003.10; 33 (10): 2773-2782. ( PubMed, DOI )

  148. Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol. 2003.09; 171 (6): 2848-2854. ( PubMed )

  149. Youngnak P, Kozono Y, Kozono H, Iwai H, Otsuki N, Jin H, Omura K, Yagita H, Pardoll DM, Chen L, Azuma M. Differential binding properties of B7-H1 and B7-DC to programmed death-1. Biochem Biophys Res Commun. 2003.08; 307 (3): 672-677. ( PubMed )

  150. Shin, T.Kennedy, G.Gorski, K.Tsuchiya, H.Koseki, H.Azuma, M.Yagita, H.Chen, L.Powell, J.Pardoll, D.Housseau, F.. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor J Exp Med. 2003.07; 198 (1): 31-38.

  151. Ansari, M. J.Salama, A. D.Chitnis, T.Smith, R. N.Yagita, H.Akiba, H.Yamazaki, T.Azuma, M.Iwai, H.Khoury, S. J.Auchincloss, H., Jr.Sayegh, M. H.. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice J Exp Med. 2003.07; 198 (1): 63-69.

  152. Salama, A. D.Chitnis, T.Imitola, J.Ansari, M. J.Akiba, H.Tushima, F.Azuma, M.Yagita, H.Sayegh, M. H.Khoury, S. J.. Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis J Exp Med. 2003.07; 198 (1): 71-78.

  153. Totsuka T, Kanai T, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, Watanabe M. Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology. 2003.02; 124 (2): 410-421. ( PubMed, DOI )

  154. Pornpan younnak,田中 香衣、高橋 雄三、小林 健、東 みゆき. 口腔扁平苔癬における抑制補助シグナル分子PD-1とそのリガンド分子発現 口腔病学会雑誌. 2003; 70 196.

  155. 津島 文彦、神村 洋介、東 みゆき. 補助シグナル操作による癌免疫治療 Biotherapy. 2003; 14 (6): 566-572.

  156. Yamazaki, T.Akiba, H.Iwai, H.Matsuda, H.Aoki, M.Tanno, Y.Shin, T.Tsuchiya, H.Pardoll, D. M.Okumura, K.Azuma, M.Yagita, H.. Expression of programmed death 1 ligands by murine T cells and APC J Immunol. 2002.11; 169 (10): 5538-5545.

  157. Iwai H, Kozono Y, Hirose S, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M. Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation. J Immunol. 2002.10; 169 (8): 4332-4339. ( PubMed )

  158. Ohata, J.Sakurai, J.Saito, K.Tani, K.Asano, S.Azuma, M.. Differential graft-versus-leukaemia effect by CD28 and CD40 co-stimulatory blockade after graft-versus-host disease prophylaxis Clin Exp Immunol. 2002.07; 129 (1): 61-68.

  159. Seko, Y.Ishiyama, S.Nishikawa, T.Kasajima, T.Hiroe, M.Suzuki, S.Ishiwata, S.Kawai, S.Tanaka, Y.Azuma, M.Kobata, T.Yagita, H.Okumura, K.Nagai, R.. Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy Cardiovasc Pathol. 2002.05; 11 (3): 166-170.

  160. Mogi, S.Ebata, T.Toda,H.Hirano,Y.Enomoto, S.Azuma, M.. The effect of recombinant CD80-Adenovirus and interleukin-12 on generation of cytotoxic T lymphocytes against autologous tumour in patients with oral squamous cell carcinoma Asian J Oral Maxillofac Surg. 2002; 14 87-94.

  161. Seko, Y.Takahashi, N.Oshima, H.Shimozato, O.Akiba, H.Takeda, K.Kobata, T.Yagita, H.Okumura, K.Azuma, M.Nagai, R.. Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3 J Pathol. 2001.12; 195 (5): 593-603.

  162. Nozawa, K.Ohata, J.Sakurai, J.Hashimoto, H.Miyajima, H.Yagita, H.Okumura, K.Azuma, M.. Preferential blockade of CD8(+) T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases J Immunol. 2001.11; 167 (9): 4981-4986.

  163. Okano, M.Azuma, M.Yoshino, T.Hattori, H.Nakada, M.Satoskar, A. R.Harn, D. A., Jr.Nakayama, E.Akagi, T.Nishizaki, K.. Differential role of CD80 and CD86 molecules in the induction and the effector phases of allergic rhinitis in mice Am J Respir Crit Care Med. 2001.10; 164 (8): 1501-1507.

  164. Hattori, H.Okano, M.Yoshino, T.Akagi, T.Nakayama, E.Saito, C.Satoskar, A. R.Ogawa, T.Azuma, M.Nishizaki, K.. Expression of costimulatory CD80/CD86-CD28/CD152 molecules in nasal mucosa of patients with perennial allergic rhinitis Clin Exp Allergy. 2001.08; 31 (8): 1242-1249.

  165. Iwakami, S. I.Setoguchi, Y.Saijo, Y.Azuma, M.Fukuchi, Y.. Replication-deficient adenovirus-mediated transfer of B7-1 (CD80) cDNA induces anti-tumour immunity in isolated human lung cancer Respirology. 2001.06; 6 (2): 135-144.

  166. Guo, Z.Wu, T.Kirchhof, N.Mital, D.Williams, J. W.Azuma, M.Sutherland, D. E.Hering, B. J.. Immunotherapy with nondepleting anti-CD4 monoclonal antibodies but not CD28 antagonists protects islet graft in spontaneously diabetic nod mice from autoimmune destruction and allogeneic and xenogeneic graft rejection Transplantation. 2001.06; 71 (11): 1656-1665.

  167. Nuriya, S.Enomoto, S.Azuma, M.. The role of CTLA-4 in murine contact hypersensitivity J Invest Dermatol. 2001.05; 116 (5): 764-768.

  168. Ebata, T.Mogi, S.Hata, Y.Fujimoto, J. I.Yagita, H.Okumura, K.Azuma, M.. Rapid induction of CD95 ligand and CD4+ T cell-mediated apoptosis by CD137 (4-1BB) costimulation Eur J Immunol. 2001.05; 31 (5): 1410-1406.

  169. Mogi, S.Sakurai, J.Kohsaka, T.Enomoto, S.Yagita, H.Okumura, K.Azuma, M.. Tumour rejection by gene transfer of 4-1BB ligand into a CD80(+) murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells Immunology. 2000.12; 101 (4): 541-547.

  170. Azuma M. [T cell costimulation and diseases]. Kokubyo Gakkai Zasshi. 2000.09; 67 (3): 233-239. ( PubMed )

  171. Saegusa, K.Ishimaru, N.Yanagi, K.Haneji, N.Nishino, M.Azuma, M.Saito, I.Hayashi, Y.. Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjogren's syndrome J Immunol. 2000.08; 165 (4): 2251-2257.

  172. Yamamoto, M.Kiyono, H.Kweon, M. N.Yamamoto, S.Fujihashi, K.Kurazono, H.Imaoka, K.Bluethmann, H.Takahashi, I.Takeda, Y.Azuma, M.McGhee, J. R.. Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses J Infect Dis. 2000.07; 182 (1): 180-190.

  173. Oki, S.Otsuki, N.Kohsaka, T.Azuma, M.. Stat6 activation and Th2 cell differentiation [correction of proliferation] driven by CD28 [correction of CD28 signals] Eur J Immunol. 2000.05; 30 (5): 1416-1424.

  174. Saegusa, K.Ishimaru, N.Yanagi, K.Haneji, N.Nishino, M.Azuma, M.Saito, I.Hayashi, Y.. Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjogren's syndrome (SS) through up-regulated Th2 response Clin Exp Immunol. 2000.02; 119 (2): 354-360.

  175. Kawamura, T.Azuma, M.Kayagaki, N.Shimada, S.Yagita, H.Okumura, K.. Fas/Fas ligand-mediated apoptosis of murine Langerhans cells J Dermatol Sci. 2000.02; 22 (2): 96-101.

  176. Kobata, T.Azuma, M.Yagita, H.Okumura, K.. Role of costimulatory molecules in autoimmunity Rev Immunogenet. 2000.02; 2 (1): 74-80.

  177. Sakurai, J.Ohata, J.Saito, K.Miyajima, H.Hirano, T.Kohsaka, T.Enomoto, S.Okumura, K.Azuma, M.. Blockade of CTLA-4 signals inhibits Th2-mediated murine chronic graft-versus-host disease by an enhanced expansion of regulatory CD8+ T cells J Immunol. 2000.01; 164 (2): 664-669.

  178. Tani, K.Nakazaki, Y.Hase, H.Takahashi, K.Azuma, M.Ohata, J.Kitamura, R.Komine, F.Oiwa, M.Masunaga, A.Maekawa, T.Satoh, N.Adachi, D.Soda, Y.Machida, .Endo, M.Yamazaki, T.Watari, K.Tojo, A.Yamashita, N.Tomikawa, S.Eriguchi, M.Hamada, H.Wakumoto, Y.Hanazawa, K.Okumura, K.. Progress reports on immune gene therapy for stage IV renal cell cancer using lethally irradiated granulocyte-macrophage colony-stimulating factor-transduced autologous renal cancer cells Cancer Chemother Pharmacol. 2000; 46 Suppl 573-576.

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Books etc 【 display / non-display

  1. Azuma M. Co-signal molecules in T cell activation:Immune regulation in health and disease. Springer, 2019.11 (ISBN : 978-981-32-9716-6)

  2. Azuma M, Oki S. In: Kishimoto T., eds. Leukocyte Typing VI: White cell differentiation antigens. Garland Publishing Inc New York & London, 1997 CD28 workshop panel report

Conference Activities & Talks 【 display / non-display

  1. L Huixin, S Yasuda, S Aoyama, C Zhang, Y Kawano, M Azuma, N Kawamata . CD80 can be the marker of chronic myeloid leukemia stem cells and regulated by BCR-ABL signaling. AACR Annual Meeting 2021 2021.04.10 U.S.A (Web)

  2. Furusawa E, Ohno T, Miyashin M, Azuma M. Topical application of B7-DC/PD-L2 siRNA inhibits contact hypersensitivity. 15th International Symposium on Dendritic Cells 2018.06.10 Aachen,Germany

  3. Nishii N, Tachinami H, Kondo Y, Xia Y, Kashima Y, Ohno T, Nagai S, Li L, Lau W, Harada H, Azuma M. Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy. 15th International Symposium on Dendritic Cells 2018.06.10 Aachen,Germany

  4. Azuma M. Immune regulation in the oral cavity. Tokyo medical and Dental University-Taipei Medical University Joint Symposium 2016.11.12 Taiwan

  5. 大野 建州、東 みゆき. 新規抑制性共刺激分子VISTAのT細胞依存的あるいは非依存的免疫応答における役割解析. 第56回歯科基礎医学会 2014.09.25 福岡

  6. Sunthamala N, Pientong C, Kongyingyoes B, Thierry F, Azuma M, Ekalaksananan T. 29th HPV16E2 protein modulates host gene transcription and promotes immunosuppressive status in tumor microenvironment. HPV 2014 2014.09.20 Seattle, USA

  7. Zhang C, Ohno T, Kang S, Bhingare AC, Takai T, Azuma M. Repeated antigen painting and sublingual immunotherapy convert sublingual dendritic cell populations. 13th International Symposium on Dendritic cells 2014.09.14 Tours, France

  8. Bhingare AC, Ohno T, Tomura M, Zhang C, Azuma M. Demonstration of dental pulp DC migration to regional Lymph nodes using photoconvertible fluorescent protein transduced mice. 13th International Symposium on Dendritic cells 2014.09.14 Tours, France

  9. Ohno T, Kondo Y, Zhang C, Azuma M. T cell-dependent and –independent regulatory roles of a new inhibitory molecule VISTA. 13th International Symposium on Dendritic cells 2014.09.14 Tours, France

  10. Kunishige T, Taniguchi H, Ohno T, Azuma M, Hori J. The V-domain Ig suppressor of T cell activation1(VISTA) plays an essential role in the acceptance of corneal allografts. International Society for Eye Research 2014 2014.07.20 USA

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Awards & Honors 【 display / non-display

  • Astra Award (Japanese Association of allergy),1998

  • Hajime Memorial Award (DNAX research institute),1992