基本情報

写真a

坂本 啓(サカモト ケイ)

SAKAM0T0 Kei


職名

講師

経歴(学内) 【 表示 / 非表示

  • 1900年01月
    -
    2018年03月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 口腔機能再構築学講座 口腔病理学 講師
  • 2018年04月
    -
    現在
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 口腔機能再構築学講座 口腔病理学 講師
 

競争的資金等の研究課題 【 表示 / 非表示

  • 破骨細胞前駆細胞から始まる全く新しい破骨細胞誘導機構と癌による骨吸収

    文部科学省/日本学術振興会 : 2020年 - 2023年

  • NOTCH1の異常による前癌病変発症機構:扁平上皮の形態ホメオスタシス制御破綻

    文部科学省/日本学術振興会 : 2016年 - 2018年

  • ナノ磁性複合分子によるDDSを用いた新規細胞周期制御法の確立と癌治療への応用

    文部科学省/日本学術振興会 : 2016年 - 2018年

  • 口腔癌における腫瘍内不均一性の形成機序と評価法に関する研究

    文部科学省/日本学術振興会 : 2015年 - 2017年

  • Notch1による扁平上皮分化調節機構とその破綻による口腔癌発生機序の解明

    文部科学省/日本学術振興会 : 2013年 - 2015年

  • 口腔癌による骨破壊メカニズムの総括的解析とその応用

    文部科学省/日本学術振興会 : 2013年 - 2015年

  • 歯髄細胞の分化におけるシグナルネットワークの新しいパラダイムの構築と臨床への展望

    文部科学省/日本学術振興会 : 2010年 - 2013年

  • オステオネットワークの維持と破綻:顎顔面骨疾患の病態解明を目指した基盤研究

    文部科学省/日本学術振興会 : 2010年 - 2012年

  • 口腔癌による骨破壊メカニズムの総括的解析とその応用

    文部科学省/日本学術振興会

  • 口腔前癌病変の癌化リスクを浸潤マーカーの免染組織像から定量評価するAIの開発

    文部科学省/日本学術振興会

  • FGF23 産生機序とリン代謝異常を基軸とする顎骨繊維性骨異形成症の包括的病態理解

    文部科学省/日本学術振興会

  • 破骨細胞前駆細胞から始まる全く新しい破骨細胞誘導機構と癌による骨吸収

    文部科学省/日本学術振興会

▼全件表示

論文・総説 【 表示 / 非表示

  1. Ishii Hiroki, Saitoh Masao, Sakamoto Kaname, Sakamoto Kei, Saigusa Daisuke, Kasai Hirotake, Ashizawa Kei, Miyazawa Keiji, Takeda Sen, Masuyama Keisuke, Yoshimura Kentaro. Lipidome-based rapid diagnosis with machine learning for detection of TGF-beta signalling activated area in head and neck cancer BRITISH JOURNAL OF CANCER. 2020.02; 122 (7): 995-1004. ( PubMed, DOI )

  2. Nguyen CTK, Sawangarun W, Mandasari M, Morita KI, Harada H, Kayamori K, Yamaguchi A, Sakamoto K. AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression. PloS one. 2020; 15 (2): e0222689. ( PubMed, DOI )

  3. Ishida Shoko, Kayamori Kou, Sakamoto Kei, Yukimori Akane, Kugimoto Takuma, Harada Hiroyuki, Ikeda Tohru. Alpha-L-fucosidase-1 is a diagnostic marker that distinguishes mucoepidermoid carcinoma from squamous cell carcinoma PATHOLOGY INTERNATIONAL. 2019.02; 69 (2): 76-85. ( PubMed, DOI )

  4. Suzuki N, Kuribayashi A, Sakamoto K, Sakamoto J, Nakamura S, Watanabe H, Harada H, Kurabayashi T. Diagnostic abilities of 3T MRI for assessing mandibular invasion of squamous cell carcinoma in the oral cavity: comparison with 64-row multidetector CT. Dento maxillo facial radiology. 2019.02; 20180311. ( PubMed, DOI )

  5. Wada Akane, Tsuchiya Maiko, Ozaki-Honda Yuu, Kayamori Kou, Sakamoto Kei, Yamaguchi Akira, Ikeda Tohru. A new osteoclastogenesis pathway induced by cancer cells targeting osteoclast precursor cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2019.01; 509 (1): 108-113. ( PubMed, DOI )

  6. Osada AH, Endo K, Kimura Y, Sakamoto K, Nakamura R, Sakamoto K, Ueki K, Yoshizawa K, Miyazawa K, Saitoh M. Addiction of mesenchymal phenotypes on the FGF/FGFR axis in oral squamous cell carcinoma cells. PloS one. 2019; 14 (11): e0217451. ( PubMed, DOI )

  7. Komiya R, Wada T, Tsushima F, Sakamoto K, Ikeda T, Yamaguchi A, Harada H, Uo M. Quantitation and distribution of metallic elements in sequestra of medication-related osteonecrosis of jaw (MRONJ) using inductively coupled plasma atomic emission spectroscopy and synchrotron radiation X-ray fluorescence analysis. Journal of bone and mineral metabolism. 2018.11; ( PubMed, DOI )

  8. Sawangarun Wanlada, Mandasari Masita, Aida Junko, Morita Kei-ichi, Kayamori Kou, Ikeda Tohru, Sakamoto Kei. Loss of Notch1 predisposes oro-esophageal epithelium to tumorigenesis EXPERIMENTAL CELL RESEARCH. 2018.11; 372 (2): 129-140. ( PubMed, DOI )

  9. Yae Ohata, Kou Kayamori, Akane Yukimori, Kanako Sumikura, Toshimitsu Ohsako, Hiroyuki Harada, Kei Sakamoto, Tohru Ikeda. A lesion categorized between ghost cell odontogenic carcinoma and dentinogenic ghost cell tumor with CTNNB1 mutation. Pathol. Int.. 2018.05; 68 (5): 307-312. ( PubMed, DOI )

  10. Yae Ohata, Maiko Tsuchiya, Hideaki Hirai, Satoshi Yamaguchi, Takumi Akashi, Kei Sakamoto, Akira Yamaguchi, Tohru Ikeda, Kou Kayamori. Leukemia inhibitory factor produced by fibroblasts within tumor stroma participates in invasion of oral squamous cell carcinoma. PLoS ONE. 2018.02; 13 (2): e0191865. ( PubMed, DOI )

  11. Akiyama Shintaro, Mochizuki Wakana, Nibe Yoichi, Matsumoto Yuka, Sakamoto Kei, Oshima Shigeru, Watanabe Mamoru, Nakamura Tetsuya. マウス結腸杯細胞集団にて、CCN3発現は独特なスルホムチン非産生亜細胞集団を標識する(CCN3 Expression Marks a Sulfomucin-nonproducing Unique Subset of Colonic Goblet Cells in Mice) Acta Histochemica et Cytochemica. 2017.12; 50 (6): 159-168. ( 医中誌 )

  12. Ohata Y, Tatsuzawa A, Ohyama Y, Ichikawa A, Mochizuki Y, Ishibashi S, Itakura Y, Sakamoto K, Ikeda T, Kitagawa M, Yamamoto K. A distinctive subgroup of oral EBV+ B-cell neoplasm with polymorphous features is potentially identical to EBV+ mucocutaneous ulcer Human Pathology. 2017.11; 69 129-139. ( DOI )

  13. Ohata Yae, Tatsuzawa Anna, Ohyama Yoshio, Ichikawa Ayako, Mochizuki Yumi, Ishibashi Sachiko, Itakura Yuri, Sakurai Urara, Sakamoto Kei, Ikeda Tohru, Kitagawa Masanobu, Yamamoto Kouhei. A distinctive subgroup of oral EBV plus B-cell neoplasm with polymorphous features is potentially identical to EBV plus mucocutaneous ulcer HUMAN PATHOLOGY. 2017.11; 69 129-139. ( PubMed, DOI )

  14. Yamagata Y, Tomioka H, Sakamoto K, Sato K, Harada H, Ikeda T, Kayamori K. CD163-Positive Macrophages Within the Tumor Stroma Are Associated With Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma J Oral Maxillofac Surg. 2017.10; 75 (10): 2144-2153. ( DOI )

  15. Yamagata Yuko, Tomioka Hirofumi, Sakamoto Kei, Sato Kiyoshi, Harada Hiroyuki, Ikeda Tohru, Kayamori Kou. CD163-Positive Macrophages Within the Tumor Stroma Are Associated With Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY. 2017.10; 75 (10): 2144-2153. ( PubMed, DOI )

  16. 大畑 八重, 山本 浩平, 立澤 杏奈, 大山 厳雄, 市川 理子, 望月 裕美, 石橋 佐知子, 坂本 啓, 池田 通, 北川 昌伸. Epstein-Barr virus陽性口腔びまん性大細胞型B細胞性リンパ腫における臨床病理学的検討および遺伝子変異解析(Clinicopathologic and gene mutation analysis of EBV-positive oral diffuse large B-cell lymphoma) 日本病理学会会誌. 2017.09; 106 (2): 86. ( 医中誌 )

  17. サワンガルン・ワンラダ , マンダサリ・マシタ , 池田 通, 坂本 啓. 4-ニトロキノリン-1-オキシドによりマウス舌に誘発された前癌病変におけるNotch1の発現減弱(Downregulation of Notch1 Expression in 4-Nitroquinoline-1-oxide-Induced Precancers of Mouse Tongue) 口腔病学会雑誌. 2017.07; 84 (2): 84-92. ( 医中誌 )

  18. Akane Yukimori, Yu Oikawa, Kei-Ichi Morita, Chi Thi Kim Nguyen, Hiroyuki Harada, Satoshi Yamaguchi, Kou Kayamori, Akira Yamaguchi, Tohru Ikeda, Kei Sakamoto. Genetic basis of calcifying cystic odontogenic tumors. PLoS ONE. 2017.06; 12 (6): e0180224. ( PubMed, DOI )

  19. Nguyen CT,Okamura T, Morita K,Yamaguchi S,Harada H,Miki Y,Izumo T,Kayamori K,Yamaguchi A,Sakamoto K. LAMC2 is a predictive marker for the malignant progression of leukoplakia Journal of Oral Pathology and Medicine. 2017.03; 46 (3): 223-231. ( DOI )

  20. Oikawa Y,Morita K,Kayamori K,Tanimoto K,Sakamoto K,Katoh H,Ishikawa S,Inazawa J,Harada H. Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma Cancer Science. 2017.02; 108 (2): 256-266.

  21. Akiyama Shintaro, Mochizuki Wakana, Nibe Yoichi, Matsumoto Yuka, Sakamoto Kei, Oshima Shigeru, Watanabe Mamoru, Nakamura Tetsuya. CCN3 Expression Marks a Sulfomucin-nonproducing Unique Subset of Colonic Goblet Cells in Mice ACTA HISTOCHEMICA ET CYTOCHEMICA. 2017; 50 (6): 159-168. ( PubMed, DOI )

  22. Sakamoto K, Matsushita Y, Minamizato T, Katsuki Y, Katsube KI, Yamaguchi A. The Bone Regeneration Model and Primary Osteoblastic Cell Culture Used in the Analysis of Ccn3 Transgenic and Knockout Mice. Methods in molecular biology (Clifton, N.J.). 2017; 1489 309-324. ( PubMed, DOI )

  23. Tomii Shohei, Akashi Takumi, Ando Noboru, Tamura Tomoki, Sakurai Akira, Terada Asami, Furukawa Asuka, Suzuki Yoshimi, Kayamori Kou, Sakamoto Kei, Ishibashi Hironori, Eishi Yoshinobu. Cortical Actin Alteration at the Matrix-Side Cytoplasm in Lung Adenocarcinoma Cells and Its Significance in Invasion PATHOBIOLOGY. 2017; 84 (4): 171-183. ( PubMed, DOI )

  24. Tomii S, Akashi T, Ando N, Tamura T, Sakurai A, Terada A, Furukawa A, Suzuki Y, Kayamori K, Sakamoto K, Ishibashi H, Eishi Y.. Cortical Actin Alteration at the Matrix-Side Cytoplasm in Lung Adenocarcinoma Cells and Its Significance in Invasion. Pathobiology.(in print). 2016.12;

  25. Oikawa Y, Morita KI, Kayamori K, Tanimoto K, Sakamoto K, Katoh H, Ishikawa S, Inazawa J, Harada H.. Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma. Cancer Science. 2016.11;

  26. Sakamoto K. Notch signaling in oral squamous neoplasia. Pathol Int. 2016.11; 66 (11): 609-617.

  27. Pal SK, Nguyen CT, Morita KI, Miki Y, Kayamori K, Yamaguchi A, Sakamoto K. THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma. J Oral Pathol Med.. 2016.09; 45 (10): 730-739.

  28. Ohata Y,Tohyama R,Kayamori K,Shimamoto H,Hirota Y,Harada H,Izumo T,Sakamoto K. A rare cancer of the tongue that demonstrated unusual histology and immunohistochemical phenotype: case report International Dentistry Scientific Meeting 2016/UI Proceedings on Health and Medicine. 2016.09; 1 (1): 172-175. ( DOI )

  29. Okamura T, Izumo T, Yagishita H, Mori T, Sakamoto K, Harada K.. Disordered arrangements of basal cells as a prognostic factor for oral epithelial dysplasia: a morphometric study of 96 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016.09; 122 (3): 355-361.

  30. Khanom R, Nguyen CT, Kayamori K, Zhao X, Morita K, Miki Y, Katsube K, Yamaguchi A, *Sakamoto K.. Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth. PLoS One. 2016.08; 11 (8): e0161163.

  31. Rei Tohyama, Kou Kayamori, Kiyoshi Sato, Miwako Hamagaki, Kei Sakamoto, Hisataka Yasuda, Akira Yamaguchi. Establishment of a xenograft model to explore the mechanism of bone destruction by human oral cancers and its application to analysis of role of RANKL. J. Oral Pathol. Med.. 2016.05; 45 (5): 356-364. ( PubMed, DOI )

  32. Kayamori K, Katsube K, Sakamoto K, Ohyama Y, Hirai H, Yukimori A, Ohata Y, Akashi T, Saitoh M, Harada K, Harada H, Yamaguchi A. NOTCH3 is induced in cancer-associated fibroblasts and promotes angiogenesis in oral squamous cell carcinoma. 2016.04; 11 (4): e0154112.

  33. Masita Mandasari, Wanlada Sawangarun, Ken-Ichi Katsube, Kou Kayamori, Akira Yamaguchi, Kei Sakamoto. A facile one-step strategy for the generation of conditional knockout mice to explore the role of Notch1 in oroesophageal tumorigenesis. Biochem. Biophys. Res. Commun.. 2016.01; 469 (3): 761-767. ( PubMed, DOI )

  34. Kuribayashi Y, Tsushima F, Morita K, Matsumoto K, Sakurai J, Uesugi A, Sato K, Oda S, Sakamoto K, Harada H. Long-term outcome of non-surgical treatment in patients with oral leukoplakia. Oral Oncol. 2015.11; 51 (11): 1020-1025. ( PubMed, DOI )

  35. Mochizuki Y, Harada H, Sakamoto K, Kayamori K, Nakamura S, Ikuta M, Kabasawa Y,Marukawa E, Shimamoto H, Tushima F, Omura K. Malignant lymphoma with initial symptoms in the mandibular region. J Cancer Ther. 2015.07; 6 (7): 554-565.

  36. Ryosuke Nakamura, Kou Kayamori, Erika Oue, Kei Sakamoto, Kiyoshi Harada, Akira Yamaguchi. Transforming growth factor-β synthesized by stromal cells and cancer cells participates in bone resorption induced by oral squamous cell carcinoma. Biochem. Biophys. Res. Commun.. 2015.03; 458 (4): 777-782. ( PubMed, DOI )

  37. Hiroki Ishii, Masao Saitoh, Kei Sakamoto, Tetsuo Kondo, Ryohei Katoh, Shota Tanaka, Mitsuyoshi Motizuki, Keisuke Masuyama, Keiji Miyazawa. Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms. J. Biol. Chem.. 2014.10; 289 (40): 27386-27399. ( PubMed, DOI )

  38. Kei Sakamoto, Kei-Ichi Morita, Yasuyuki Shimada, Ken Omura, Toshiyuki Izumo, Akira Yamaguchi. Peripheral odontogenic keratocyst associated with nevoid basal cell carcinoma syndrome: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014.07; 118 (1): e19-e23. ( PubMed, DOI )

  39. Zhao Xin, Akira Yamaguchi, Kei Sakamoto. Aberrant expression and altered cellular localization of desmosomal and hemidesmosomal proteins are associated with aggressive clinicopathological features of oral squamous cell carcinoma. Virchows Arch.. 2014.07; 465 (1): 35-47. ( PubMed, DOI )

  40. Yuki Matsushita, Kei Sakamoto, Yoshihiro Tamamura, Yasuaki Shibata, Tokutaro Minamizato, Tasuku Kihara, Masako Ito, Ken-ichi Katsube, Shuichi Hiraoka, Haruhiko Koseki, Kiyoshi Harada, Akira Yamaguchi. CCN3 protein participates in bone regeneration as an inhibitory factor. J. Biol. Chem.. 2013.07; 288 (27): 19973-19985. ( PubMed, DOI )

  41. Kiyoshi Sato, Ji-Won Lee, Kei Sakamoto, Tadahiro Iimura, Kou Kayamori, Hisataka Yasuda, Masanobu Shindoh, Masako Ito, Ken Omura, Akira Yamaguchi. RANKL synthesized by both stromal cells and cancer cells plays a crucial role in osteoclastic bone resorption induced by oral cancer. Am. J. Pathol.. 2013.05; 182 (5): 1890-1899. ( PubMed, DOI )

  42. Samir Kumar Pal, Kei Sakamoto, Tadanobu Aragaki, Takumi Akashi, Akira Yamaguchi. The expression profiles of acidic epithelial keratins in ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013.04; 115 (4): 523-531. ( PubMed, DOI )

  43. Yasuyuki Shimada, Ken-ichi Katsube, Yuji Kabasawa, Kei-ichi Morita, Ken Omura, Akira Yamaguchi, Kei Sakamoto. Integrated genotypic analysis of hedgehog-related genes identifies subgroups of keratocystic odontogenic tumor with distinct clinicopathological features. PLoS ONE. 2013; 8 (8): e70995. ( PubMed, DOI )

  44. Masao Saitoh, Takuya Shirakihara, Akira Fukasawa, Kana Horiguchi, Kei Sakamoto, Hiroshi Sugiya, Hideyuki Beppu, Yasuyuki Fujita, Ikuo Morita, Kohei Miyazono, Keiji Miyazawa. Basolateral BMP signaling in polarized epithelial cells. PLoS ONE. 2013; 8 (5): e62659. ( PubMed, DOI )

  45. Sakamoto K, Khanom R, Hamagaki M, Yamaguchi A. Ectopic production of hair keratin constitutes Rushton's hyaline bodies in association with hematogenous deposits. Journal of Oral Pathology and Medicine. 2012.09; 41 (8): 637-641.

  46. Oue E, Lee JW, Sakamoto K, Iimura T, Aoki K, Kayamori K, Michi Y, Yamashiro M, Harada K, Amagasa T, Yamaguchi A. CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone Biochemical and Biophysical Research Communications. 2012.08; 424 (3): 456-461.

  47. Umehara K, Iimura T, Sakamoto K, Lin Z, Kasugai S, Igarashi Y, Yamaguchi A. Canine oral mucosal fibroblasts differentiate into osteoblastic cells in response to BMP-2. Anatomical Record. 2012.08; 295 (8): 1327-1335.

  48. Khanom R, Sakamoto K, Pal SK, Shimada Y, Morita K, Omura K, Miki Y, Yamaguchi A. Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies. Histology and Histopathology. 2012.07; 27 (7): 949-959.

  49. Horiguchi K, Sakamoto K, Koinuma D, Semba K, Inoue A, Inoue S, Fujii H, Yamaguchi A, Miyazawa K, Miyazono K, *Saitoh M.. TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP. Oncogene. 2012.06; 31 (26): 3190-3201.

  50. Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, Kayamori K, Katsube K, Yamaguchi A. Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Laboratory Investigation. 2012.05; 92 (5): 688-702.

  51. Shinichi Hirooka, Takumi Akashi, Noboru Ando, Yoshimi Suzuki, Noriko Ishida, Morito Kurata, Touichirou Takizawa, Kou Kayamori, Kei Sakamoto, Naoyuki Fujiwara, Masao Kojima, Yoshinobu Eishi. Localization of the invadopodia-related proteins actinin-1 and cortactin to matrix-contact-side cytoplasm of cancer cells in surgically resected lung adenocarcinomas. Pathobiology. 2011; 78 (1): 10-23. ( PubMed, DOI )

  52. Aragaki T, Michi Y, Katsube K, Uzawa N, Okada N, Akashi T, Amagasa T, Yamaguchi A, Sakamoto K. Comprehensive keratin profiling reveals different histopathogenesis of keratocystic odontogenic tumor and orthokeratinized odontogenic cyst. Hum Pathol. 2010.12; 41 (12): 1718-1725. ( PubMed, DOI )

  53. Wang S, Kawashima N, Sakamoto K, Katsube K, Umezawa A, Suda H. Osteogenic differentiation of mouse mesenchymal progenitor cell, Kusa-A1 is promoted by mammalian transcriptional repressor Rbpj. Biochem Biophys Res Commun. 2010.09; 400 (1): 39-45. ( PubMed, DOI )

  54. Kou Kayamori, Kei Sakamoto, Tomoki Nakashima, Hiroshi Takayanagi, Kei-Ichi Morita, Ken Omura, Su Tien Nguyen, Yoshio Miki, Tadahiro Iimura, Akiko Himeno, Takumi Akashi, Hisafumi Yamada-Okabe, Etsuro Ogata, Akira Yamaguchi. Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells. Am. J. Pathol.. 2010.02; 176 (2): 968-980. ( PubMed, DOI )

  55. Watanabe K, Nagaoka T, Lee JM, Bianco C, Gonzales M, Castro NP, Rangel MC, Sakamoto K, Sun Y, Callahan R, Salomon DS. Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1. J Cell Biol. 2009.11; 187 (3): 343-353. ( PubMed, DOI )

  56. Katsube K, Ichikawa S, Katsuki Y, Kihara T, Terai M, Lau LF, Tamamura Y, Takeda S, Umezawa A, Sakamoto K, Yamaguchi A. CCN3 and bone marrow cells. J Cell Commun Signal. 2009.06; 3 (2): 135-145. ( PubMed, DOI )

  57. Katsube K, Sakamoto K, Tamamura Y, Yamaguchi A. Role of CCN, a vertebrate specific gene family, in development. Dev Growth Differ. 2009.01; 51 (1): 55-67. ( PubMed, DOI )

  58. Ishikuro M, Sakamoto K, Kayamori K, Akashi T, Kanda H, Izumo T, Yamaguchi A. Significance of the fibrous stroma in bone invasion by human gingival squamous cell carcinomas. Bone. 2008.09; 43 (3): 621-627. ( PubMed, DOI )

  59. Sakamoto K, Tamamura Y, Katsube K, Yamaguchi A. Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells. J Cell Sci. 2008.05; 121 (Pt 10): 1613-1623. ( PubMed, DOI )

  60. Katsuki Y, Sakamoto K, Minamizato T, Makino H, Umezawa A, Ikeda MA, Perbal B, Amagasa T, Yamaguchi A, Katsube K. Inhibitory effect of CT domain of CCN3/NOV on proliferation and differentiation of osteogenic mesenchymal stem cells, Kusa-A1. Biochem Biophys Res Commun. 2008.04; 368 (3): 808-814. ( PubMed, DOI )

  61. Liu T, Gao Y, Sakamoto K, Minamizato T, Furukawa K, Tsukazaki T, Shibata Y, Bessho K, Komori T, Yamaguchi A. BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines. J Cell Physiol. 2007.06; 211 (3): 728-735. ( PubMed, DOI )

  62. Minamizato T, Sakamoto K, Liu T, Kokubo H, Katsube K, Perbal B, Nakamura S, Yamaguchi A. CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways. Biochem Biophys Res Commun. 2007.03; 354 (2): 567-573. ( PubMed, DOI )

  63. Takahashi S, Kawashima N, Sakamoto K, Nakata A, Kameda T, Sugiyama T, Katsube K, Suda H. Differentiation of an ameloblast-lineage cell line (ALC) is induced by Sonic hedgehog signaling. Biochem Biophys Res Commun. 2007.02; 353 (2): 405-411. ( PubMed, DOI )

  64. Sakamoto K, Chao WS, Katsube K, Yamaguchi A. Distinct roles of EGF repeats for the Notch signaling system. Exp Cell Res. 2005.01; 302 (2): 281-291. ( PubMed, DOI )

  65. Kawashima N, Shindo K, Sakamoto K, Kondo H, Umezawa A, Kasugai S, Perbal B, Suda H, Takagi M, Katsube K. Molecular and cell biological properties of mouse osteogenic mesenchymal progenitor cells, Kusa. J Bone Miner Metab. 2005; 23 (2): 123-133. ( PubMed, DOI )

  66. Katsube K, Sakamoto K. Notch in vertebrates--molecular aspects of the signal. Int J Dev Biol. 2005; 49 (2-3): 369-374. ( PubMed, DOI )

  67. Jia L, Esguerra RL, Tang X, Yin H, Sakamoto K, Okada N, Takagi M. Prognostic value of apoptosis and apoptosis-associated proteins in salivary gland adenoid cystic carcinoma. Pathol Int. 2004.04; 54 (4): 217-223. ( PubMed, DOI )

  68. Esguerra RL, Jia L, Kaneko T, Sakamoto K, Okada N, Takagi M. Immunohistochemical analysis of centromere protein F expression in buccal and gingival squamous cell carcinoma. Pathol Int. 2004.02; 54 (2): 82-89. ( PubMed )

  69. Shindo K, Kawashima N, Sakamoto K, Yamaguchi A, Umezawa A, Takagi M, Katsube K, Suda H. Osteogenic differentiation of the mesenchymal progenitor cells, Kusa is suppressed by Notch signaling. Exp Cell Res. 2003.11; 290 (2): 370-380. ( PubMed )

  70. Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K. The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. J Biol Chem. 2002.08; 277 (33): 29399-29405. ( PubMed, DOI )

  71. Sakamoto K, Ohara O, Takagi M, Takeda S, Katsube K. Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification. Dev Biol. 2002.01; 241 (2): 313-326. ( PubMed, DOI )

  72. Katsube K, Chuai ML, Liu YC, Kabasawa Y, Takagi M, Perbal B, Sakamoto K. The expression of chicken NOV, a member of the CCN gene family, in early stage development. Brain Res Gene Expr Patterns. 2001.08; 1 (1): 61-65. ( PubMed )

  73. Suzuki M, Sakamoto K, Takeda S, Takagi M, Katsube K. Molecular cloning of the chick Nau gene and analysis of its expression patterns during neurogenesis. J Med Dent Sci. 1998.06; 45 (2): 123-133. ( PubMed )

  74. Sakamoto K, Nakamura H, Takagi M, Takeda S, Katsube K. Ectopic expression of lunatic Fringe leads to downregulation of Serrate-1 in the developing chick neural tube; analysis using in ovo electroporation transfection technique. FEBS Lett. 1998.04; 426 (3): 337-341. ( PubMed )

  75. Sakamoto K, Yan L, Imai H, Takagi M, Nabeshima Y, Takeda S, Katsube K. Identification of a chick homologue of Fringe and C-Fringe 1: involvement in the neurogenesis and the somitogenesis. Biochem Biophys Res Commun. 1997.05; 234 (3): 754-759. ( PubMed )

  76. Sakamoto K, Katsube K, Takagi M, Takeda S. [Analysis of gene Fringe related to neurogenesis using chick embryo]. Kokubyo Gakkai Zasshi. 1997.03; 64 (1): 160. ( PubMed )

  77. 大畑 八重, 立澤 杏奈, 大山 厳雄, 市川 理子, 望月 裕美, 石橋 佐知子, 櫻井 うらら, 坂本 啓, 池田 通, 北川 昌伸, 山本 浩平. 多形性の細胞形態を示す口腔EBウイルス陽性B細胞性腫瘍は、EBウイルス陽性粘膜皮膚潰瘍に高率に合致する 日本リンパ網内系学会会誌. 2018.05; 58 117. ( 医中誌 )

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講演・口頭発表等 【 表示 / 非表示

  1. グエン・ファン・テーフィ , 坂本 啓, 池田 通. 舌疾患での異形成を分類する際に、口腔病理学者を補助するためのディープラーニングの利用(Deep-learning application for supporting oral pathologists in dysplasia grading of tongue lesions). 日本病理学会会誌 2021.03.01

  2. ゲエン・ファン・テー・フィ , 坂本 啓, 池田 通. 舌の前癌病変を示唆する組織学的特徴を同定するためのディープラーニングの応用(Deep-learning application for identifying histological features suggestive of precancer in tongue). 日本病理学会会誌 2020.03.01

  3. 大畑八重、栢森高、 平井秀明、 土谷麻衣子、山口聡、原田浩之、坂本啓、池田通. 口腔扁平上皮癌における癌関連線維芽細胞の生物学的重要性. 第28回日本臨床口腔病理学会総会・学術大会 2017.08.24 川越

  4. Uo M, Wada T, Komiya R, Harada H, Sakamoto K, Ikeda T, Yamaguchi A. Trace metallic element accumulation in the sequestrum of medication-related osteonecrosis of the jaw (MRONJ). 14th International Symposium on Applied Bioinorganic hemistry – ISABC14 June 7-10th 2017 2017.06.07 Toulouse, France

  5. Thi Chi kim Nguyen、岡村武志、森田圭一、山口聰、原田浩之、出雲俊之、栢森高、山口朗、坂本啓. LAMC2 is a predictive marker for malignant progression of leukoplakia. 2016.08.12

  6. Wanlada Sawangarun, 坂本啓. Oral and esophageal tumorigenesis in conditional Notch1 knockout mouse model. 第27回日本臨床口腔病理学会総会 2016.08.12

  7. 大畑八重、行森茜、栢森高、原田浩之、出雲俊之、坂本啓. 左上顎腫瘍の1例 Tumor of the left maxilla: case report. 第27回日本臨床口腔病理学会総会 2016.08.11

  8. Sakamoto K. Molecular markers useful in diagnosis of oral premalignancies.. KPPIKG 2016.02.25

  9. Morita K, Oikawa Y, Kayamori K, Sakamoto K, Ishikawa S, Inazawa J, Harada H. Targeted resequencing of cancer-related genes in oral cancer. The 34th Sapporo International Cancer Symposium 2015.06.26 Sapporo, Japan

  10. Sakamoto K. Diagnostic pathology of oral cancer and premalignant lesions.. The 19th scientific congress and dental exhibition 2015.05.14 HoChiMinh city, Vietnam

  11. Yasuyuki Shimada, Kei Sakamoto, Kou Kayamori, Akira Yamaguchi. Clonal analysis of keratocystic odontogenic tumor. 17th International Congresson Oral Pathology and Medicine, 2014.05 Istanbul

  12. Kei Sakamoto. Pathology of odontogenic tumor. Workshop ‘Update on Jaw Disease’ 2014.03.29 Ho Chi Minh City

  13. 鈴木紀子、栗林亜実、坂本潤一郎、坂本 啓、渡邊 裕、倉林 亨. 口腔悪性腫瘍の下顎骨浸潤における3D-VIBEとCTとの比較. 日本歯科放射線学会 第22回臨床画像大会 2017.11.11 岩手県盛岡市

  14. 小宮瑠里,宇尾基弘,津島文彦,坂本 啓,池田 通,山口 朗,原田浩之. MRONJの腐骨中に蓄積した微量金属元素の定量および分布分析. 第62回日本口腔外科学会学術集会 2017年10月20-22日 2017.10.20 京都

  15. 土谷 麻衣子、遠山 怜、坂本 啓、鵜澤 一成、池田 通. 一部にエナメル上皮癌に類似する歯原性嚢胞由来の原発性骨内癌、NOSの一例. 第28回日本臨床口腔病理学会総会・学術大会 2017.08.23

  16. 和田 あかね、栢森 高、佐藤 百合子、坂本 啓、池田 通. 歯肉頬移行部の非乾酪壊死性の類上皮細胞肉芽腫を契機に診断されたサルコイドーシスの1例. 第28回日本臨床口腔病理学会総会・学術大会 2017.08.23

  17. 及川 悠, 森田 圭一, 栢森 高, 坂本 啓, 谷本 幸介, 加藤 洋人, 石川 俊平, 稲澤 譲治, 原田 浩之. 口腔扁平上皮癌における遠隔転移予測因子としてのチロシンキナーゼ受容体. 第35回日本口腔腫瘍学会総会・学術大会 2017年1月26-27日 2017.01.26 福岡市

  18. 山形優子,栢森 高,富岡寛文,佐藤 潔,坂本 啓,原田浩之. 口腔扁平上皮癌進展におけるマクロファージの役割. 第61回日本口腔外科学会総会・学術大会 2016年11月25-27日 2016.11.25 千葉市

  19. 及川 悠,森田圭一,栢森 高,坂本 啓,谷本幸介,石川俊平,稲澤譲治,原田浩之. 口腔がんにおけるがん関連遺伝子変異のターゲットリシーケンス. 第54回日本癌治療学会 2016年10月20-22日 2016.10.20 横浜市

  20. 及川 悠,森田圭一,栢森 高,坂本 啓,石川俊平,稲澤譲治,原田浩之. Clinical application of cell-free DNA in oral cancer. 第75回日本癌学会 2016年10月6-8日 2016.10.06 横浜市

  21. 上條陽輝、行森茜、坂本啓. 顎口腔領域のランゲルハンス細胞組織球症の病理組織学的検討. 2016.08.11

  22. 行森茜、栢森高、森田圭一、坂本啓. 歯原性腫瘍におけるBRAF変異(V600E)と臨床病理学的因子との関連の検討. 第105回日本病理学会総会 2016.05.13

  23. 角倉可奈子,平井秀明,大迫利光,礒部 薫,富岡寛文,坂本 啓,原田浩之. 上顎に発生した歯原性幻影細胞癌の1例. 第70回日本口腔科学会学術集会 2016年4月15-17日 2016.04.15 福岡市

  24. 坂本 啓. エナメル上皮腫の病理. 第34回日本口腔腫瘍学会総会・学術大会 2016.01.21

  25. 坂本 啓. NOTCH1の司る扁平上皮分化とその破綻による腫瘍発生機序. 第61回日本病理学会秋期特別総会 2015.11.06 東京

  26. Nguyen Thi Kim Chi, Kei Sakamoto, Akira Yamaguchi. Expression of AIRE (Autoimmune Regulator) in Oral Squamous Cell Carcinoma. 第103回日本病理学会総会 2014.04 広島

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