Screening with an RNA binding protein library identified new regulators of microRNA.
We identified novel regulators of tumor suppressor microRNAs.
The function of the epigenome on bone morphogenesis was analyzed using micro-CT.
We have been shown that the tendons/ligaments specific transcription factor Mohawk is essential for the development and homeostasis processes in tendons and ligaments.
We have been developed completely automated ChIP system using LabDroid “Maholo”.
Search for novel regulator of microRNA by high throughput screening.
Established novel strategies for the osteoporosis by targeting molecules critical for the bone homeostasis.
Revealed the molecular mechanism by which osteocytes regulate bone homeostasis.
Analyzed the bone phenotype of spaceflight mice.
Analyzed molecular mechanisms by which the bone tissue regulates the energy metabolism.
The Screening of novel Damage-associated molecular patterns proteins
Protein localization analysis by High-throughput microscope system
MiRNA which regulates cartilage homeostasis was identified.
We developed screening system for miRNA target genes using reporter vector library.
MicroRNA KO mice were generated using CRISPR/Cas9 system, and its function in skeletal pattern formation was analyzed.
Molecular mechanisms and in vivo roles of RNA-binding proteins and long non-coding RNAs in the context of inflammatory response
Conducting “Molecular Genetics”, which is a series of lectures to understand the gene expression machinery and human genetics and their application to current medicine and biology. Under graduate students can join the lab works to learn the skills for molecular biology and pathology.
Organizing “Development and Regeneration” lecture series to understand the basis for regenerative medicine and reproduction at the level of molecular genetics.
Students can join the Lab to perform researches using various experimental techniques, such as microarray, cell-based high throughput screening etc. Using these techniques, core molecular network for tissue development and inflammatory diseases will be examined, which forms the basis of systems biomedicine.