Our laboratory is committed to comprehensive research on endogenous psychosis， neurosis， and epilepsy through biological, psychological and social approaches. In collaboration with external research facilities, we are also involved in social psychiatry. child and adolescent psychiatry, and brain imaging studies.
1)Studies in biological psychiatry
(i)Molecular genetic studies to clarify the causes and conditions of neuropsychiatric diseases:
Using animal models with psychotic symptom-causing agents, we are involved in a study to isolate new candidate gene clusters associated with the pathogenesis and pathophysiology of neuropsychiatric disorders from the viewpoint of developmental pharmacology. We are examining the effects of candidate gene clusters in patients with neuropsychiatric disorders.
(ii)Studies in biochemical pharmacology to develop new therapeutic methods for neuropsychiatric disorders.
(iii)A study of sleep stages and behavior in neuropsychiatric diseases:
A study is being carried out to examine sleep stages and behavior using an originally developed automatic analysis device (polysomnography) in patients with various psychiatric disorders.
(iv)A study on brain functioning in psychiatric disorders by using the near-infrared spectroscopy (NIRS):
To obtain an insight into biological markers of psychiatric disorders, changes in regional brain functions during psychological tasks are examined by measuring the relative concentrations of oxyhemoglobin using NIRS in combination with MRI in the brain areas of the patients with schizophrenia and mood disorders.
2) Psychopathological studies
We are conducting psychological studies of neuropsychiatric diseases from the aspects of phenomenology, anthropology, and linguistics, while employing a psychotherapeutic approach. Other research activities include a review of basic psychiatric concepts and a basic study for the c1assification and diagnosis of psychiatric disorders, which are important recent issues. In addition to endogenous psychosis including schizophrenia and manic depressive disorder. we are also involved in psychoanalytic studies of neurosis and borderline personality disorder, which are attracting increasing attention, and psychotherapies for them, as well as pathological research on pathography and art therapy in terms of creativity.
3) Forensic Psychiatry Research
Our research includes projects in the development of forensic psychiatric evaluation methodology, risk assessment and management in forensic settings, exploring associations and mechanisms of criminal behavior.
Following the two-year period of mandatory clinical training, basic professional training in psychiatry will be provided for 6-9 months mainly in the university. In the second term of training, they will acquire knowledge and clinical experience necessary for neuropsychiatrists， and undergo practical training at affiliated medical facilities to become qualified psychiatrists. Undergraduate education, which places emphasis on clinical clerkship training after a systematic series of lecture course and seminar-based classes, is designed to develop students' problem-solving skills, and increase their motivation to learn neuropsychiatry, with support from external facilities.
Lectures & Courses
In the first term (two years) of postgraduate training, residents will learn basic laboratory procedures and diagnostictechniques,psychotherapy and drug treatment and laws and regulations related to clinical practice, and acquire other general knowledge，all being essential for biologic ，la psychological, social, and ethical approaches to neuropsychiatric diseases.
Clinical Services & Other Works
Approximately eighty new outpatients visit our department every month, about 30% of which are classified as having “mood disorders" (F3) by ICO-10, followed by "neurotic, stress-related, and somatoform disorders" (F4) and “schizophrenia, schizophrenic and paranoid disorders" (F2). We are also actively involved in consultation and liaison psychiatry for inpatients in other departments. Patients with snile dementia, child and adolescent psychiatric disorders, substance, dependence, and neurosis requiring intensive psychotherapy are often referred to related and advanced facilities for specialized treatment. Since this facility, the psychiatric department of a general hospital, is used for university education and training, most inpatients are c1assified as F2, followed by F4 and F3 (ICD-10). We also provide care and treatment for patients with sleep rhythm disorders and neurological disorders, including epilepsy and senile dementia. In addition to drug treatment, we have introduced and provided mECT (modified electroconvulsive therapy) for inpatients, and individual and group psychotherapy for the patients in our psychiatric ward and clinic and day care center in close collaboration with rehabilitation facilities in the community. The day care team consists of a doctor, two nurses. And a psycho-social-worker or a clinical psychologist. Day care (partial hospitalization) is the transitional element between inpatient and outpatient care and its indications have a wide range of psychiatric disorders as follows: schizophrenia, depression, bipolar disorder, adjustment disorder and personality disorders. Each member has the own aim and the team gives care with different types of framework. Our day care team regards the potentiality of group very important and the group process could contribute to therapeutic effect. With this kind of experience, patients could develop their ability to communicate with other people and readapt to social situations.
(i)A study of biological indicators in schizophrenia with eye cameras:
We are not only involved in studies of monozygotic twins，early-onset patients，and children at a high risk in Japan, but also in an international joint research project of the WHO as a center in charge of operations.
Since the 2011 fiscal year, we have been conducting the clinical trial of D-cycloserine for negative symptoms such as avolition, flattening of affect, and poverty of thought and cognitive dysfunction of schizophrenia. We also have been treating patients with schizophrenia with clozapine, which has been approved for refractory schizophrenia. We have started getting systematically involved in the treatment of patients complaining of pain or dysesthesia in oral regions in liaison with the Dental Hospital, which is the unique characteristics of our university. In the 2014 fiscal year, we started the psychoeducational program for patients with bipolar disorder, which focuses on the prevention of relapse. In addition, there is an increasing number of liaison activities for the prevention of delirium especially in the surgical wards, the intervention to patients with suicide attempts in the emergency room, and the mental support for peripartum patients in cooperation with the staffs.