1)Regulation of bone remodeling by bone cells
2)Identification of bone-derived systemic regulatory factors (osteokines)
3)Mechanism of sensing and adapting to mechanical stress
4)Functional analysis of genes by gene manipulations and gene-disrupted mice
5)Development of clinical application by experimental animal disease models
Purpose of Education
Organized signal networks in the body are crucial for the higher physiological functions and the tissue organization. To understand the regulation of signal events, we take on cell signaling course including the molecular mechanism of both the “intra”cellular and the “inter”cellular signal transduction. Especially, the course will be focused on the molecular networks of signal transduction in osteoclasts, osteoblasts and osteocytes which is a new integrated field of osteonetwork (systemic network between bone and other systems). Besides, to promote the practical and clinical understanding, the course will deal with the molecular mechanism of osteoporosis and inflammatory bone destructed diseases, such as periodontal disease and rheumatoid arthritis, in parallel with the basic molecular biology.