Personnel Information

写真a

HOMMA Kengo


Job title

Junior Associate Professor

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Pharmaceutical Science, 2008.03, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Doctor's Course, 2013.03, Completed

Campus Career 【 display / non-display

  • 2018.05
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Developmental and Regenerative Biology, Junior Associate Professor

External Career 【 display / non-display

  • 2013.04
    -
    2014.03
    , Project Researcher
  • 2014.04
    -
    2017.03
    , Project Assistant Professor
  • 2018.02
    -
    2018.04
    , Project Researcher
 

Published Papers & Misc 【 display / non-display

  • 藤澤 貴央, 圓谷 奈保美, 本間 謙吾, 一條 秀憲. アカデミア創薬の過去、現在、そして未来 SOD1-Derlin-1結合を標的とした低分子化合物によるALS病態モデルの改善 日本生化学会大会プログラム・講演要旨集. 2018.09; 91回 [1S01e-02]. ( ichushi )

  • Tsuburaya N, Homma K, Higuchi T, Balia A, Yamakoshi H, Shibata N, Nakamura S, Nakagawa H, Ikeda SI, Umezawa N, Kato N, Yokoshima S, Shibuya M, Shimonishi M, Kojima H, Okabe T, Nagano T, Naguro I, Imamura K, Inoue H, Fujisawa T, Ichijo H. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nature communications. 2018.07; 9 (1): 2668. ( PubMed, DOI )

  • Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H. The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. Science translational medicine. 2017.05; 9 (391): ( PubMed, DOI )

  • Atsushi Tsubota, Hidenori Ichijo, Kengo Homma. Mislocalization, aggregation formation and defect in proteolysis in ALS AIMS Molecular Science. 2016.05; ( DOI )

  • Hayashi Y, Homma K, Ichijo H. SOD1 in neurotoxicity and its controversial roles in SOD1 mutation-negative ALS. Advances in biological regulation. 2016.01; 60 95-104. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • 圓谷 奈保美, 本間 謙吾, 一條 秀憲. ALS治療に向けたSOD1-Derlin-1結合阻害化合物の同定. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2015.12.01

  • 中島 勇祐, 本間 謙吾, 一條 秀憲. SOD1-Derlin-1複合体形成機構の解析. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2015.12.01

  • Ichijo Hidenori, Homma Kengo. 亜鉛シグナル伝達 生理と病因における新しい調節機構 亜鉛欠乏下で恒常的ERストレス反応を開始するための分子スイッチとしてのSOD1(Zinc signaling: An emerging regulatory system in physiology and pathogenesis SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency). The Journal of Physiological Sciences 2015.03.01

  • 圓谷 奈保美, 本間 謙吾, 藤澤 貴央, 一條 秀憲. ALSの発症機構解明と治療に向けたSOD1-Derlin-1結合阻害化合物の探索. 日本生化学会大会プログラム・講演要旨集 2014.10.01

  • 本間 謙吾, 一條 秀憲. 亜鉛シグナルから理解する細胞機能と病態形成 亜鉛欠乏状態下での恒常性調節のための小胞体ストレス応答を開始する分子スイッチとしてのSOD1(SOD1 as a molecular switch for initiating the homeostatic ER stress response under conditions of zinc deficiency). 日本生化学会大会プログラム・講演要旨集 2014.10.01

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