Personnel Information

写真a

NOGAMI Ayako


Job title

Assistant Professor

Graduating School 【 display / non-display

  • Yamaguchi University, Faculty of Medicine, 2007.03, Graduated

Campus Career 【 display / non-display

  • 2011.04
    -
    2015.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Hematology, Graduate Student
  • 2015.04
    -
    2016.03
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Hematology, Senior Resident
  • 2016.04
    -
    2017.03
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Internal Medicine, Hematology, Assistant Professor
  • 2017.04
    -
    2018.12
    Tokyo Medical and Dental University, Medical Hospital, Central Clinical Facilities, Clinical Laboratory, Assistant Professor
  • 2019.01
    -
    Now
    Tokyo Medical and Dental University, Medical Hospital, Central Clinical Facilities, Clinical Laboratory, Assistant Professor
 

Published Papers & Misc 【 display / non-display

  • Nagao T, Kurosu T, Umezawa Y, Nogami A, Oshikawa G, Tohda S, Yamamoto M, Miura O. Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera. PLoS ONE. 2014; 9 (1): e84746. ( PubMed, DOI )

  • Nogami Ayako, Okada Keigo, Ishida Shinya, Akiyama Hiroki, Umezawa Yoshihiro, Miura Osamu. Inhibition of the STAT5/Pim Kinase Axis Enhanecs Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway TRANSLATIONAL ONCOLOGY. 2019.02; 12 (2): 336-349. ( PubMed, DOI )

  • Ishida S, Akiyama H, Umezawa Y, Okada K, Nogami A, Oshikawa G, Nagao T, Miura O. Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2. Oncotarget. 2018.06; 9 (42): 26834-26851. ( PubMed, DOI )

  • Keigo Okada, Ayako Nogami, Shinya Ishida, Hiroki Akiyama, Cheng Chen, Yoshihiro Umezawa and Osamu Miura. FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway Oncotarget. 2017.12; 9 8870-8886.

  • Yoshihiro Umezawa, Hiroki Akiyama, Keigo Okada, Shinya Ishida, Ayako Nogami, Gaku Oshikawa, Tetsuya Kurosu, Osamu Miura. Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1). Journal of Biological Chemistry. 2017.12; 292 (48): 19639-19655.

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Conference Activities & Talks 【 display / non-display

  • Ayako Nogami, Keigo Okada, Daisuke Watanabe, Hiroki Akiyama, Yoshihiro Umezawa, Shinya Ishida, Gaku Oshikawa, Shuji Tohda, Osamu Miura . Proteasome Inhibitors Downregulate the mTORC1/4EBP1/S6K/Mcl-1 Pathway Cooperatively with Inhibitors for The STAT5/Pim Kinase Pathway to Induce Apoptosis in FLT3-ITD-positive AML Cells. The 9th JSH International Symposium 2018 2018.07.28 Kyoto

  • Hiroki Akiyama, Yoshihiro Umezawa, Keigo Okada, Shinya Ishida, Ayako Nogami, and Osamu Miura. Deubiquitinase Inhibitor WP1130 Blocks FLT3-ITD to Induce Apoptosis in Leukemic Cells. 59th ASH Annual Meeting & Exposition 2017.12.17 Atlanta, GA, USA

  • Tomoko Yamashita, Hiroki Tsutsumi, Kota Yoshifuji, Tatsuya Saito, Yoshihiro Umezawa, Ayako Nogami, Ken Watanabe, Toshikage Nagao, Chizduko Sakashita, Masahide Yamamoto, Ayako Arai, Norihiko Kawamata, Osamu Miura, Tetsuya Fukuda. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with 11q Deletion. 第79回日本血液学会学術集会 2017.10.22

  • Hiroki Akiyama, Yoshihiro Umezawa, Keigo Okada, Shinya Ishida, Ayako Nogami, Toshikage Nagao, Osamu Miura. Deubiquitinase inhibitor WP1130 blocks JAK2-V617F to induce apoptosis in leukemic cells. The 79th Annual Meeting of the Japanese Society of Hematology 2017.10.21 Tokyo

  • Keigo Okada, Ayako Nogami, Cheng Chen, Maho kawakami, Hiroki Akiyama, Shinya Ishida, Yoshihiro Umezawa, Osamu Miura. FLT3-ITD confers resistance to PI3K/Akt inhibitors by enhancing mTORC1/Mcl-1 pathway via Pim kinase. 第79回日本血液学会学術集会 2017.10.20

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