Personnel Information

写真a

KOBAYAKAWA Takuya


Job title

Assistant Professor

Laboratory Address

2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan

Laboratory Phone number

+81-3-5280-8039

Laboratory Fax number

+81-3-5280-8039

Mail Address

The inquiry by e-mail is 《here

Homepage URL

http://www.tmd.ac.jp/i-mde/www/en/biomolecular/index1.html

Research Areas, Keywords

Synthetic Organic Chemistry, Medicinal Chemistry, Chemical Biology, Peptide Chemistry, Peptidomimetic Chemistry

Graduating School 【 display / non-display

  • Waseda University, School of Advance Science and Engineering, Department of Applied Chemistry, 2012.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Science and Technology Track, Master's Course, 2014.03, Completed

  • Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology Track, Doctor's Course, 2017.03, Completed

Degree 【 display / non-display

  • Doctor (Engineering), Tokyo Medical and Dental University

  • Master (Engineering), Tokyo Medical and Dental University

  • Bachelor (Engineering), Waseda University

Campus Career 【 display / non-display

  • 2012.04
    -
    2014.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Science and Technology, Graduate Student
  • 2014.04
    -
    2017.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Medicinal Chemistry, Graduate Student
  • 2017.04
    -
    2017.09
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Biomolecular Chemistry, Medicinal Chemistry, Junior Associate Professor
  • 2017.10
    -
    Now
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Biomolecular Chemistry, Medicinal Chemistry, Assistant Professor

External Career 【 display / non-display

  • 2014.04
    -
    2016.03
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Research Assistant
  • 2015.04
    -
    2016.03
    Tokyo Kasei University,
  • 2016.04
    -
    2017.03
    Japan Society for the Promotion of Science, Research Fellowships for Young Scientists, Research Fellowships for Young Scientists
  • 2017.04
    -
    2017.09
    Japan Society for the Promotion of Science, Research Fellowships for Young Scientists, Research Fellowships for Young Scientists

Academic Society Affiliations 【 display / non-display

  • The Pharmaceutical Society of Japan

  • Japanese Society for Chemical Biology

  • The Society of Synthetic Organic Chemistry, Japan

  • The Japanese Peptide Society

  • American Chemical Society

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Academic Activity 【 display / non-display

  • 2013.06
     
     
    The 8th Annual Meeting of Japanese Society for Chemical Biology The 8th Annual Meeting of Japanese Society for Chemical Biology, Cooperation Staff
  • 2017.10
    -
    Now
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University Open Campus Committee
  • 2018.06
     
     
    The 13th Annual Meeting of Japanese Society for Chemical Biology The 13th Annual Meeting of Japanese Society for Chemical Biology, Cooperation Staff

Research Areas 【 display / non-display

  • Chemical pharmacy

  • Organic chemistry

  • Synthetic chemistry

  • Drug development chemistry

  • Chemical biology

Qualification Acquired 【 display / non-display

  • Hazardous Material Handler (first kind)

  • Usual Car License (first kind)

 

Published Papers & Misc 【 display / non-display

  • Sakyiamah MM, Nomura W, Kobayakawa T, Tamamura H. Development of a NanoBRET-Based Sensitive Screening Method for CXCR4 Ligands. Bioconjugate chemistry. 2019.04; ( PubMed, DOI )

  • Kobayakawa T, Ebihara K, Honda Y, Fujino M, Nomura W, Yamamoto N, Murakami T, Tamamura H. C34 Dimeric Derivatives Utilizing Disulfide Bridges as Novel HIV-1 Fusion Inhibitors. Chembiochem : a European journal of chemical biology. 2019.04; ( PubMed, DOI )

  • Kobayakawa Takuya, Konno Kiju, Ohashi Nami, Takahashi Kohei, Masuda Ami, Yoshimura Kazuhisa, Harada Shigeyoshi, Tamamura Hirokazu. Soluble-type small-molecule CD4 mimics as HIV entry inhibitors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2019.03; 29 (5): 719-723. ( PubMed, DOI )

  • Sakyiamah MM, Kobayakawa T, Fujino M, Konno M, Narumi T, Tanaka T, Nomura W, Yamamoto N, Murakami T, Tamamura H. Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands. Bioorganic & medicinal chemistry. 2019.02; ( PubMed, DOI )

  • Matsuda K, Kobayakawa T, Tsuchiya K, Hattori SH, Nomura W, Gatanaga H, Yoshimura K, Oka S, Endo Y, Tamamura H, Mitsuya H, Maeda K. Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C-induced HIV latency reversal. The Journal of biological chemistry. 2019.01; ( PubMed, DOI )

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Books etc 【 display / non-display

  • Synthesis Technology of Peptides, Nucleic Acids and Sugar Chains for Medium Molecule Drug Discovery. CMC Publishing Co.,Ltd., 2018.02 (ISBN : 978-4-7813-1320-7)

  • Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi. Mid-size Drugs Based on Peptides and Peptidomimetics. Springer Singapore, 2018.01 (ISBN : 978-981-10-7691-6)

  • Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura. Stereoselective Synthesis of Chloroalkene Dipeptide Isosteres Utilizing Organocopper Reagents. The Japanese Peptide Society, 2016.03

  • Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura. Development of Efficient Synthetic Methodologies of Chloroalkene Dipeptide Isosteres. in "Peptide Science 2014," ed. by Akira Otaka, The Japanese Peptide Society, Osaka. The Japanese Peptide Society, 2015.03

Conference Activities & Talks 【 display / non-display

  • Structure-activity relationship study of low molecular anti-HIV-1 agents based on Capsid protein of HIV-1. 2019.03.22

  • Wataru Nomura , Takumi Kamimura, Daisuke Matsumoto, Takuya Kobayakawa, Hirokazu Tamamura. Fluorogenic and genetically encodable tag-probe system for in-cell imaging of protein synthesis . 10th International Peptide Symposium 2018.12.05 Kyoto, Japan

  • Takuya Kobayakawa, Hirokazu Tamamura. Synthetic Strategy of Peptidomimetic Based on Chloroalkene Dipeptide Isoteres and Its Biological Application. 10th International Peptide Symposium 2018.12.03 Kyoto, Japan

  • Kento Ebihara, Yuzuna Honda, Takuya Kobayakawa, Tsutomu Murakami, Hirokazu Tamamura. HIV-1 Fusion Inhibitors Based on gp41-C34 dimers. 10th International Peptide Symposium 2018.12.03 Kyoto, Japan

  • Kohei Takahashi, Ami Masuda, Shigeyoshi Harada, Takuya Kobayakawa, Yusuke Ishida, Yu Irahara, Tomoyuki Miura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura. Novel CD4 mimics Increase the Activity of HIV Neutralizing Antibodies. 2018.11.28 Kyoto, Japan

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Campus class subject 【 display / non-display

  • Practical Chemical Biology,2018 - Now

  • Development of Functional Molecules,2018 - Now

  • Introduction to Chemistry and Biology of Biofunctional Molecules,2018 - Now

External class subject 【 display / non-display

  • ,Tokyo Kasei University

  • ,Tokyo Kasei University

Performance of duties 【 display / non-display

  • ,2019.01

  • ,2019.01

  • ,2019.01

  • ,2018.08

  • ,2018.06

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Social Contribution 【 display / non-display

  • Frontier Research on Medicinal Chemistry of Mid-sized Molecules,Kanazawa, Japan,2018.03.28