Personnel Information

写真a

KAKINUMA Sei


Job title

Associate Professor

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo

Research Areas, Keywords

liver regeneration, liver cirrhosis, stem cells

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, School of Medicine, 1995, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Internal Medicine, Doctor's Course, 2003, Completed

Degree 【 display / non-display

  • M.D., Ph.D., Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 2017.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Liver Disease Control, Associate Professor
  • 2013.04
    -
    2017.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Liver Disease Control, Junior Associate Professor

External Career 【 display / non-display

  • 2005.04
    -
    2005.08
    , fellow
  • 2003.09
    -
    2005.05
    , Gastroenterology and Hepatology, Assistant Professor
  • 2008.04
    -
    2009.03
    , Research Associate
  • 2009.04
    -
    2013.03
    Tokyo Medical and Dental University, Graduate School, Department of Hepatitis Control, Junior Associate Professor
  • 2013.04
    -
    2017.03
    , Junior Associate Professor

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Research Areas 【 display / non-display

  • Gastroenterology

  • Cell biology

Qualification Acquired 【 display / non-display

  • Doctor

 

Research Theme 【 display / non-display

  • Cell biology of hepatic stem/progenitor cells,Cell transplantation for liver diseases,Developmental biology of liver

Published Papers & Misc 【 display / non-display

  • Tomoyuki Tsunoda, Sei Kakinuma, Masato Miyoshi, Akihide Kamiya, Shun Kaneko, Ayako Sato, Jun Tsuchiya, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Tsuyoshi Sogo, Haruki Komatsu, Ryutaro Mukouchi, Ayano Inui, Tomoo Fujisawa, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe. Loss of fibrocystin promotes interleukin-8-dependent proliferation and CTGF production of biliary epithelium. J. Hepatol.. 2019.07; 71 (1): 143-152. ( PubMed, DOI )

  • Masato Miyoshi, Sei Kakinuma, Akihide Kamiya, Tomoyuki Tsunoda, Jun Tsuchiya, Ayako Sato, Shun Kaneko, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe. LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. Sci Rep. 2019.02; 9 (1): 2072. ( PubMed, DOI )

  • Shun Kaneko, Sei Kakinuma, Yasuhiro Asahina, Akihide Kamiya, Masato Miyoshi, Tomoyuki Tsunoda, Sayuri Nitta, Yu Asano, Hiroko Nagata, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Hiromitsu Nakauchi, Hironori Nishitsuji, Saneyuki Ujino, Kunitada Shimotohno, Masashi Iwamoto, Koichi Watashi, Takaji Wakita, Mamoru Watanabe. Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus. Sci Rep. 2016.07; 6 29358. ( PubMed, DOI )

  • Fumio Goto, Sei Kakinuma, Masato Miyoshi, Tomoyuki Tsunoda, Shun Kaneko, Ayako Sato, Yu Asano, Satoshi Otani, Seishin Azuma, Hiroko Nagata, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Yasuhiro Asahina, Mamoru Watanabe. Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells. Hepatol. Res.. 2017.08; 47 (9): 941-952. ( PubMed, DOI )

  • Satoshi Otani, Sei Kakinuma, Akihide Kamiya, Fumio Goto, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Fukiko Kawai-Kitahata, Sayuri Nitta, Toru Nakata, Ryuichi Okamoto, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Yasuhiro Asahina, Tomoyuki Yamaguchi, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Mamoru Watanabe. Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells. Biochem. Biophys. Res. Commun.. 2016.01; 469 (4): 1062-1068. ( PubMed, DOI )

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Books etc 【 display / non-display

  • Promising resources of hepatic progenitor cells. (Review) In: Okita K, eds. Stem cell and Liver regeneration.. Springer Press, 2003

Conference Activities & Talks 【 display / non-display

  • Yasuhiro Asahina Y, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma. Comprehensive analysis of cancer gene mutations and viral integration in hepatocellular carcinoma arising from non-fibrotic liver. AASLD The Liver Meeting 2019 2019.11.10 Hynes Convention Center

  • Nitta S, Kato T, Tuchiya J, Sato A, Tsunoda T, Miyoshi M, Inoue- Shinomiya E, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Asahina Y. The Characteristic and the Anti-HCV Reagents Susceptibility Analysis of NS5A Resistance-Associated Substitutions (RAS) Detected after Daa Treatment Failure Patients. AASLD, The Liver Meeting 2018 2018.11.10 San Francisco (USA)

  • Asahina Y, Kawai-Kitahata F, Murakawa M, Nitta S, Nakagawa M, Kakinuma S, Watanabe M. Gene Mutational Profile and Viral Integration in Hepatocellular Carcinoma with or without HBV/HCV Suppression. AASLD, The Liver Meeting 2018 2018.11.10 San Francisco (USA)

  • Nitta S, Kato T, Tuchiya J, Shinomiya-Inoue E, Sato A, Tsunoda T, Miyoshi M, Kitahata-Kawai F, Murakawa M, Istui Y, Azuma S, Nakagawa M, Kakinuma S, Asahina Y. The in vitro analysis of NS5A resistance-associated substitutions (RAS) observed in DAA treatment failure patients. 25th International Symposium on Hepatitis C Virus and Related Viruses 2018.10.09 Dublin(Ireland)

  • Y Asahina, S Kakinuma . HBV reactivation and changes in interferon-stimulated gene expression during treatment of direct-acting antivirals for HCV: Analyses in a novel in vitro model for HBV-HCV coinfection using human induced pluripotent stem cell-derived hepatic cells . EASL, The International Liver Congress 2018 2018.04.14 Paris(France)

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Awards & Honors 【 display / non-display

  • Foundation Award in hepatology research of 17th Symposium in Hamanako,2010

  • Foundation Award in hepatology research of 10th Liver Forum in Kyoto,2007

  • President Award in 13th Annual Meeting of the Japanese Society for the Research of Hepatic Cells,2006

  • Foundation Award in hepatology research of 5th Liver Forum in Kyoto,2002

  • Foundation Award in hepatology research of 9th Symposium in Hamanako,2001

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