Personnel Information

写真a

NOBUHISA Ikuo


Job title

Associate Professor

Birth date

1970

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan

Mail Address

The inquiry by e-mail is 《here

Homepage URL

http://www.tmd.ac.jp/mri/scr/english/index.html

Research Areas, Keywords

hematopoiesis

Graduating School 【 display / non-display

  • Kyushu University, Faculty of Science, 1993.03, Graduated

Graduate School 【 display / non-display

  • Kyushu University, Graduate School, Division of Natural Science, Department of Chemistry, Master's Course, 1995.03, Completed

  • Kyushu University, Graduate School, Division of Natural Science, Department of Chemistry, Doctor's Course, 1998.03, Completed

Degree 【 display / non-display

  • Ph.D., Kyushu University

Campus Career 【 display / non-display

  • 2009.04
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Stem Cell Regulation, Associate Professor
  • 2009.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Stem Cell Regulation, Associate Professor

External Career 【 display / non-display

  • 1995.04
    -
    1998.03
    , JSPS Research Fellow
  • 1998.04
    -
    2000.07
    , JSPS Research Fellow
  • 2000.08
    -
    2005.03
    Kumamoto University, Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics,
  • 2005.04
    -
    2009.03
    Kumamoto University, Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Junior Associate Professor

Research Areas 【 display / non-display

  • Molecular biology

  • Cell biology

  • Developmental biology

 

Published Papers & Misc 【 display / non-display

  • Saito K, Nobuhisa I, Harada K, Takahashi S, Anani M, Lickert H, Kanai-Azuma M, Kanai Y, and Taga T . Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis Exp Cell Res. 2018.04; 365 (1): 145-155. ( DOI )

  • Harada K, Nobuhisa I, Anani M, Saito K, Taga T. Thrombopoietin contributes to the formation and the maintenance of hematopoietic progenitor-containing cell clusters in the aorta-gonad-mesonephros region. Cytokine. 2017.07; 95 32-42. ( PubMed, DOI )

  • Kouichi Tabu, Nozomi Muramatsu, Christian Mangani, Mei Wu, Rong Zhang, Taichi Kimura, Kazuo Terashima, Norihisa Bizen, Ryosuke Kimura, Wenqian Wang, Yoshitaka Murota, Yasuhiro Kokubu, Ikuo Nobuhisa, Tetsushi Kagawa, Issay Kitabayashi, Mark Bradley and Tetsuya Taga. A synthetic polymer scaffold reveals the self-maintenance strategies of rat glioma stem cells by organization of the advantageous niche. Stem Cells. 2016.05; 34 1151-1162. ( DOI )

  • Yasuhiro Kokubu, Kouichi Tabu, Wenqian Wang, Nozomi Muramatsu, Yoshitaka Murota, Ikuo Nobuhisa, Masahisa Jinushi, and Tetsuya Taga. Induction of protumoral CD11c[high] macrophages by glioma cancer stem cells through GM-CSF. Genes to Cells. 2016.03; 21 241-251. ( DOI )

  • Anani M, Nobuhisa I, Osawa M, Iwama A, Harada K, Saito K, and Taga T. Sox17 as a candidate regulator of myeloid restricted differentiation potential. Dev Growth Differ. 2014.08; 56 (6): 496-479. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Hagihara H, Shoji H, Kohno T, Hayata A, Tamada K, Hori K, Tatsukawa T, Shibutani M, Wakatsuki S, Hagino Y, Kasahara T, Numakawa T, Ohtabi H, Nobuhisa I, Hoshiba Y, Nakamura H, Katori S, Yamanishi K, Takamiya Y, Tanaka M, Yalcin I, Matsushita M, Hattori M, Hashimoto H, Takumi T, Hoshino M, Tabuchi K, Yamakawa K, Hatada I, Ikeda K, Kato T, Kunugi H, Toyoda A, Taga T, Hayashi-Takagi A, Goshima Y, Iwasato T, Okabe S, Meltzer HY, Miyakawa T. Systematic analysis of brain pH and lactate levels in animal models: relationships and implications for behavioral outcomes. The 21st Annual Meeting of the International Behavioural and Neural Genetics Society 2019.05.10 the University of Edinburgh, Edinburgh, Scotland, UK

  • Nobuhisa I, Saito K, Azuma K, Iizauka N, and Taga T. The contribution of TET1 to the maintenance of the hematopoietic capacity in hematopoietic stem cell-containing clusters in the dorsal aorta in midgestation mouse embryo. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.10 Fukuoka International Congress Center, Fukuoka, Japan

  • Azuma K, Nobuhisa I, Saito K, Iizuka N, and Taga T. The role of an epigenetic factor TET1 in undifferentiated hematopoietic cell clusters in the embryonic AGM region where definitive hematopoiesis arises. The 41th Annual Meeting of the Molecular Biology Society of Japan 2018.11.29 Pacifico Yokohama, Yokohama, Japan

  • Saito K, Nobuhisa I, and Taga T. Expression analysis of Tet family members in AGM region. The 41th Annual Meeting of the Molecular Biology Society of Japan 2018.11.29 Pacifico Yokohama, Yokohama, Japan

  • Iizuka N, Nobuhisa I Saito K, Azuma K, and Taga T. Involvement of an NF-κB signal pathway in the maintenance of an undifferentiated state of hematopoietic stem cell-containing clusters in the midgestation mouse dorsal aorta. The 41th Annual Meeting of the Molecular Biology Society of Japan 2018.11.29 Pacifico Yokohama, Yokohama, Japan

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