Personnel Information

写真a

TAMAMURA Hirokazu


Job title

Professor

Birth date

1964

Graduating School 【 display / non-display

  • Kyoto University, Faculty of Pharmaceutical Science, 1988, Graduated

Degree 【 display / non-display

  • Doctor of Pharmacy, Kyoto University

Campus Career 【 display / non-display

  • 2015.04
    -
    Now
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Biomolecular Chemistry, Medicinal Chemistry, Professor
  • 2014.04
    -
    2015.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Molecular Biomedicine, Professor
  • 2014.01
    -
    2015.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Medicinal Chemistry, Professor
  • 2015.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Medicinal Chemistry, Professor

Research Areas 【 display / non-display

  • Drug development chemistry

 

Published Papers & Misc 【 display / non-display

  • Kobayakawa Takuya, Konno Kiju, Ohashi Nami, Takahashi Kohei, Masuda Ami, Yoshimura Kazuhisa, Harada Shigeyoshi, Tamamura Hirokazu. Soluble-type small-molecule CD4 mimics as HIV entry inhibitors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2019.03; 29 (5): 719-723. ( PubMed, DOI )

  • Suzuki Akinobu Z., Sekine Ryota, Takeda Shiori, Aikawa Ryosuke, Shiraishi Yukiko, Hamaguchi Tomomi, Okuno Hiroyuki, Tamamura Hirokazu, Furuta Toshiaki. A clickable caging group as a new platform for modular caged compounds with improved photochemical properties CHEMICAL COMMUNICATIONS. 2019.01; 55 (4): 451-454. ( PubMed, DOI )

  • Matsuda K, Kobayakawa T, Tsuchiya K, Hattori SH, Nomura W, Gatanaga H, Yoshimura K, Oka S, Endo Y, Tamamura H, Mitsuya H, Maeda K. Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C-induced HIV latency reversal. The Journal of biological chemistry. 2019.01; 294 (1): 116-129. ( PubMed, DOI )

  • Kobayakawa T, Ohashi N, Hirota Y, Takahashi K, Yamada Y, Narumi T, Yoshimura K, Matsushita S, Harada S, Tamamura H. Flexibility of small molecular CD4 mimics as HIV entry inhibitors. Bioorganic & medicinal chemistry. 2018.10; 26 (21): 5664-5671. ( PubMed, DOI )

  • Nomura W, Matsumoto D, Sugii T, Kobayakawa T, Tamamura H. Efficient and orthogonal transcription regulation by chemically inducible artificial transcription factors. Biochemistry. 2018.10; 57 (45): 6452-6459. ( PubMed, DOI )

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Books etc 【 display / non-display

  • Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi. Mid-size Drugs Based on Peptides and Peptidomimetics. 2018.01 (ISBN : 978-981-10-7691-6)

  • Ohashi N, Tamamura H. “Peptide-derived mid-sized anti-HIV agents” In “Amino Acids, Peptides and Proteins,” ed. by Maxim Ryadnov and Ferenc Hudecz, The Royal Society of Chemistry, Cambridge CB4 0WF, UK, vol. 41. 2017.01

  • Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura. tereoselective Synthesis of Chloroalkene Dipeptide Isosteres Utilizing Organocopper Reagents. The Japanese Peptide Society, 2016.03

  • Takano H, Narumi T, Nomura W, Furuta T, Tamamura H. Development of 8-Azacoumarin-4-ylmethyl-type Photolabile Protecting Groups Based on Amide-Alkene Isosterism. in "Peptide Science 2014," ed. by Akira Otaka, The Japanese Peptide Society, Osaka. 2015

  • Kobayakawa T, Narumi T, Tamamura H. Development of Efficient Synthetic Methodologies of Chloroalkene Dipeptide Isosteres. in "Peptide Science 2014," ed. by Akira Otaka, The Japanese Peptide Society, Osaka. 2015

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Conference Activities & Talks 【 display / non-display

  • Tamamura H. Peptide drug discovery. 25th Peptide Forum – International Forum on Peptides in Drug Discovery - /Satellite Symposium of 10th International Peptide Symposium 2018.12.10 Tokyo, Japan

  • Wataru Nomura , Takumi Kamimura, Daisuke Matsumoto, Takuya Kobayakawa, Hirokazu Tamamura. Fluorogenic and genetically encodable tag-probe system for in-cell imaging of protein synthesis . 10th International Peptide Symposium/55th Japanese Peptide Symposium 2018.12.05 Kyoto, Japan

  • 小早川 拓也, 玉村 啓和. Synthetic Strategy of Peptidomimetic Based on Chloroalkene Dipeptide Isoteres and Its Biological Application. 10th International Peptide Symposium/55th Japanese Peptide Symposium 2018.12.03 Kyoto, Japan

  • Tamamura H. Peptidomimetic-based mid-size drugs: anti-cancer and anti-HIV agents. 10th International Peptide Symposium/55th Japanese Peptide Symposium 2018.12.03 Kyoto, Japan

  • Kento Ebihara, Yuzuna Honda, Takuya Kobayakawa, Tsutomu Murakami, Hirokazu Tamamura. HIV-1 Fusion Inhibitors Based on gp41-C34 dimers. 10th International Peptide Symposium/55th Japanese Peptide Symposium 2018.12.03 Kyoto, Japan

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Campus class subject 【 display / non-display

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