Personnel Information

写真a

OKAZAWA Hitoshi


Job title

Professor

Laboratory Phone number

+81-3-5803-5847

Mail Address

okazawa.npat@mri.tmd.ac.jp

Homepage URL

http://www.tmd.ac.jp/mri/npat/index.html

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Medicine, School of Medicine, 1984, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Medicine, Doctor's Course, 1991, Completed

Degree 【 display / non-display

  • MD, PhD, The University of Tokyo

Campus Career 【 display / non-display

  • 2003.06
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Neuropathology, Professor
  • 2003.06
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neuropathology, Professor
  • 2014.04
    -
    Now
    Tokyo Medical and Dental University, Research and Industry-University Alliance Organization, Center for Brain Integration Research, Director

Academic Activity 【 display / non-display

  • The Japan Neuroscience Society Program commissioner,2005,2007
  • The Japan Neuroscience Society Council
  • The Japan Society for Neurochemistry Council
  • Japan Society for Dementia Research Council
  • The Molecular Biology Society of Japan committee

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Research Areas 【 display / non-display

  • Neurology

  • Pathological medical chemistry

  • Molecular biology

  • Nerve anatomy/Neuropathology

  • Neurophysiology / General neuroscience

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Research Theme 【 display / non-display

  • neurodegeneration,developmental disorder,stem cell, 2009 - 2015

  • neurodegeneration,developmental disorder,stem cell

Published Papers & Misc 【 display / non-display

  • Rahmn SK, Okazawa H, Chen YW. Frameshift PQBP-1 mutants K192Sfs*7 and R153Sfs*41 implicated in X-linked intellectual disability form stable dimers Journal of Structural Biology. 2019.06; 206 (3): 305-313. ( DOI )

  • Bannai T, Mano T, Chen X, Ohtomo G, Ohtomo R, Tsuchida T, Koshi-Mano K, Hashimoto T, Okazawa H, Iwatsubo T, Tsuji S, Toda T, Iwata A. Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight. Scientific Reports. 2019.02; 9 (1): 2827. ( DOI )

  • Xigui Chen,Kanoh Kondo, Hitoshi Okazawa. Methods to image macroautophagy in the brain in vivo. Methods in Molecular Biology. 2019.01; 1880 529-534.

  • Inoue S, Hayashi K, Fujita K, Tagawa K, Okazawa H, Kubo K, Nakajima K. Drebrin-like (Dbnl) controls neuronal migration via regulating N-cadherin expression in the developing cerebral cortex. Journal of Neuroscience. 2019.01; 39 (4): 678-691. ( DOI )

  • Tanaka H, Kondo K, Chen X, Homma H, Tagawa K, Kerever A, Aoki S, Saito T, Saido T, Muramatsu S, Fujita K, Okazawa H. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Mol psychiatry. 2018.10; 23 (10): 2090-2110. ( DOI )

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Conference Activities & Talks 【 display / non-display

  • Hitoshi Okazawa. Alzheimer’s disease and Autophagy. The 38th Annual Meeting of Japan Society for Dementia Research 2019.11.07 Keio Plaza Hotel(Tokyo)

  • Hitoshi Okazawa. New therapeutics development against ultra-early phase AD pathology. The 38th Annual Meeting of Japan Society for Dementia Research 2019.11.07 Keio Plaza Hotel(Tokyo)

  • Hitoshi Okazawa. HMGB1 and Neurodegeneration. 9th International DAMPs and Alarmins Symposium 2019.11.06 Okayama University Shikata Campus(Okayama)

  • Hitoshi Okazawa. Targeting HMGB1-mediated expansion of neurodegeneration at the ultra-early phase pathology of Alzheimer’s disease. AsCNP2019 2019.10.12 Fukuoka Sunpalace Hotel and Hall (Fukuoka)

  • Hikari Tanaka, Kanoh Kondo, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Aurelian Kerever, Shigeki Aoki, Takashi Saito, Takaomi Saido, Shin-ichi Muramatsu, Kyota Fujita, Hitoshi Okazawa. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. NEURO2019 2019.07.27 Toki Messe(Niigata)

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Patents 【 display / non-display

  • A prevention or a drug to cure by spinocerebellar degeneration

    Patent Number: 2013-214155

Awards & Honors 【 display / non-display

  • Narabayashi Award,Japanese Society of Neurology,2011.05