Personnel Information

写真a

AKIYAMA Yoshimitsu


Job title

Junior Associate Professor

Laboratory Phone number

+81-3-5803-5186

Research Areas, Keywords

Epigenetics, Colorectal cancer, Gastric cancer, Genetic alteration, HNPCC

Graduating School 【 display / non-display

  • Toho University, Faculty of Science, Biology, 1989, Graduated

Graduate School 【 display / non-display

  • University of Tsukuba, Graduate School, Division of Medical Science, Master's Course, 1993, Completed

Degree 【 display / non-display

  • Ph.D, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 2003.08
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Molecular Oncology, Junior Associate Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Molecular Oncology, Junior Associate Professor

Academic Society Affiliations 【 display / non-display

  • Japanese Cancer Association

  • American Association for Cancer Research

  • The Japanese Society for Epigenetics

  • The Molecular Biology Society of Japan

Research Areas 【 display / non-display

  • Pathological medical chemistry

  • Human pathology

 

Published Papers & Misc 【 display / non-display

  • Ueda H, Akiyama Y, Shimada S, Mogushi K, Serizawa M, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S.. Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs. Endocr Relat Cancer. 2018.06; 25 (6): 619-631.

  • Shu Shimada, Yoshimitsu Akiyama, Kaoru Mogushi, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiromi Nagasaki, Hiroshi Fukamachi, Yasuhito Yuasa, Shinji Tanaka. Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models. Br. J. Cancer. 2018.04; 118 (7): 972-984. ( PubMed, DOI )

  • Mizuno Y, Shimada S, Akiyama Y, Watanabe S, Aida T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Yamaoka S, Tanabe M, Tanaka S.. DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma. Sci Rep. . 2018.01; 8 (1):

  • Gao D, Herman JG, Cui H, Jen J, Fuks F, Brock MV, Ushijima T, Croce C, Akiyama Y, Guo M.. Meeting Report of the Fifth International Cancer Epigenetics Conference in Beijing, China, October 2016. Epigenomics. 2017.07; 9 (7): 937-941. ( PubMed, DOI )

  • Ohata Y, Shimada S, Akiyama Y, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S. . Acquired resistance with epigenetic alterations under long-term anti-angiogenic therapy for hepatocellular carcinoma Molecular Cancer Therapeutics. 2017.06; 16 (6): 1155-1165. ( DOI )

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Conference Activities & Talks 【 display / non-display

  • Yoshimitsu Akiyama, Shu Shimada, Minoru Tanabe, Shinji Tanaka. DAXX acts as a tumor suppressor through histone H3.3/H3K9me3 pathway in pancreatic neuroendocrine tumors. The 77th Annual Meeting of the Japanese Cancer Association 2018.09.29 Osaka

  • Yuki Mizuno, Shu Shimada, Yoshimitsu Akiyama, Shuichi Watanabe,Tomomi Aida, Kosuke Ogawa、Hiroaki Ono, Yusuke Mitsunori、Daisuke Ban, Atsushi Kudo, Shoji Yamaoka, Shinji Tanaka, Minoru Tanabe. DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma. Yuki Mizuno, Shu Shimada, Yoshimitsu Akiyama, Shuichi Watanabe,Tomomi Aida, Kosuke Ogawa、Hiroaki Ono, Yusuke Mitsunori、Daisuke Ban, Atsushi Kudo, Shoji Yamaoka, Shinji Tanaka, Minoru Tanabe 2018.09.28 Osaka

  • Shuichi Watanabe、Shu Shimada、Yoshimitsu Akiyama、Kosuke Ogawa、Hiroaki Ono、Yusuke Mitsunori、Daisuke Ban、Atsushi Kudo、Minoru Tanabe、Shinji Tanaka. Precision medicine for the poorest prognosis subtype of pancreatic cancer. The 73rd General Meeting of the Japanese Society of Gastroenterological Surgery 2018.07.12 Kagoshima

  • Akiyama Y, Nishikawaji T, Shimada S, Yuasa Y, Tanaka S.. Molecular mechanisms of SETDB2 histone methyltransferase overexpression in gastric cancer.. 第76回日本癌学会総会 2017.09.30 横浜

  • Fukamachi H, Nishikawaji T, Shimada S, Akiyama Y, Yuasa Y, Tsuchiya K, Tanaka S. . Identification of signal transduction pathway in PDX-derived diffuse-type gastric tumor-initiating cells.. 第76回日本癌学会総会 2017.09.30 横浜

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Patents 【 display / non-display

  • Hypermethylation of GATA-4 and GATA-5 transcription factor genes in cancer. (Oncomethylome Sciences SA)

    Patent Number: JHU 4309